SPINK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.87255566
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95888651
3neuronal action potential (GO:0019228)3.60920749
4behavioral response to ethanol (GO:0048149)3.48796953
5pyrimidine nucleobase catabolic process (GO:0006208)3.47811153
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47019806
7protein polyglutamylation (GO:0018095)3.46593483
8nonmotile primary cilium assembly (GO:0035058)3.45032915
9kynurenine metabolic process (GO:0070189)3.39062844
10epithelial cilium movement (GO:0003351)3.37092616
11regulation of action potential (GO:0098900)3.36377543
12indole-containing compound catabolic process (GO:0042436)3.33877787
13indolalkylamine catabolic process (GO:0046218)3.33877787
14tryptophan catabolic process (GO:0006569)3.33877787
15primary amino compound metabolic process (GO:1901160)3.32965192
16positive regulation of action potential (GO:0045760)3.32035667
17serotonin metabolic process (GO:0042428)3.30901097
18L-fucose metabolic process (GO:0042354)3.30349481
19L-fucose catabolic process (GO:0042355)3.30349481
20fucose catabolic process (GO:0019317)3.30349481
21transmission of nerve impulse (GO:0019226)3.28959413
22indolalkylamine metabolic process (GO:0006586)3.22373179
23somite development (GO:0061053)3.20883053
24piRNA metabolic process (GO:0034587)3.06038702
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02266152
26reflex (GO:0060004)3.01393992
27response to pheromone (GO:0019236)3.00222320
28gamma-aminobutyric acid transport (GO:0015812)2.99962889
29indole-containing compound metabolic process (GO:0042430)2.95179896
30neural tube formation (GO:0001841)2.93215518
31mitochondrial respiratory chain complex I assembly (GO:0032981)2.92880414
32NADH dehydrogenase complex assembly (GO:0010257)2.92880414
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92880414
34amine catabolic process (GO:0009310)2.92727616
35cellular biogenic amine catabolic process (GO:0042402)2.92727616
36nucleobase catabolic process (GO:0046113)2.91209358
37cilium movement (GO:0003341)2.90321320
38cilium or flagellum-dependent cell motility (GO:0001539)2.89615258
39negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85593079
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85079557
41detection of light stimulus involved in visual perception (GO:0050908)2.83083063
42detection of light stimulus involved in sensory perception (GO:0050962)2.83083063
43negative regulation of sodium ion transport (GO:0010766)2.82304263
44sulfation (GO:0051923)2.80662113
45tryptophan metabolic process (GO:0006568)2.80275154
46membrane depolarization during action potential (GO:0086010)2.78803739
47regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.78097009
48regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.78097009
49cilium organization (GO:0044782)2.78031133
50protein complex biogenesis (GO:0070271)2.76957759
51cilium morphogenesis (GO:0060271)2.76786019
52axoneme assembly (GO:0035082)2.75149409
53nephron tubule morphogenesis (GO:0072078)2.74756863
54nephron epithelium morphogenesis (GO:0072088)2.74756863
55regulation of neurotransmitter uptake (GO:0051580)2.73343766
56cilium assembly (GO:0042384)2.71167409
57postsynaptic membrane organization (GO:0001941)2.69707141
58cardiovascular system development (GO:0072358)2.68407935
59synaptic transmission, cholinergic (GO:0007271)2.65288505
60regulation of gene silencing by RNA (GO:0060966)2.64979617
61regulation of posttranscriptional gene silencing (GO:0060147)2.64979617
62regulation of gene silencing by miRNA (GO:0060964)2.64979617
63cellular ketone body metabolic process (GO:0046950)2.63597498
64negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63436313
65head development (GO:0060322)2.62836405
66retinal cone cell development (GO:0046549)2.62815472
67protein localization to synapse (GO:0035418)2.62421066
68positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.61896485
69negative regulation of systemic arterial blood pressure (GO:0003085)2.60435187
70protein localization to cilium (GO:0061512)2.59872158
71auditory behavior (GO:0031223)2.59729581
72negative regulation of telomere maintenance (GO:0032205)2.59464763
73negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58689170
74negative regulation of mast cell activation (GO:0033004)2.58056939
75peristalsis (GO:0030432)2.57336320
76regulation of cilium movement (GO:0003352)2.57131306
77parturition (GO:0007567)2.56514935
78positive regulation of gastrulation (GO:2000543)2.55580412
79action potential (GO:0001508)2.55216350
80cell proliferation in forebrain (GO:0021846)2.54228536
81mitochondrial respiratory chain complex assembly (GO:0033108)2.52980884
82ubiquinone biosynthetic process (GO:0006744)2.52106475
83photoreceptor cell maintenance (GO:0045494)2.50039102
84neuron cell-cell adhesion (GO:0007158)2.49914335
85positive regulation of sodium ion transmembrane transport (GO:1902307)2.48969797
86dendritic spine morphogenesis (GO:0060997)2.48235948
87snRNA transcription (GO:0009301)2.46889963
88replication fork processing (GO:0031297)2.46321052
89endoderm formation (GO:0001706)2.46236369
90intraciliary transport (GO:0042073)2.45935285
91retinal ganglion cell axon guidance (GO:0031290)2.45339816
92kidney morphogenesis (GO:0060993)2.44222390
93rhodopsin mediated signaling pathway (GO:0016056)2.43499159
94central nervous system myelination (GO:0022010)2.43022794
95axon ensheathment in central nervous system (GO:0032291)2.43022794
96ubiquinone metabolic process (GO:0006743)2.42814172
97water-soluble vitamin biosynthetic process (GO:0042364)2.41717535
98spinal cord motor neuron differentiation (GO:0021522)2.40117902
99DNA methylation involved in gamete generation (GO:0043046)2.39780860
100photoreceptor cell development (GO:0042461)2.39241510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39423264
2ZNF274_21170338_ChIP-Seq_K562_Hela3.54828517
3VDR_22108803_ChIP-Seq_LS180_Human3.23297264
4GBX2_23144817_ChIP-Seq_PC3_Human3.02815534
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63095135
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56058889
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52444733
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46465412
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23668905
10IGF1R_20145208_ChIP-Seq_DFB_Human2.15719174
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09668851
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07576355
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96574499
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.93536440
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92270018
16P300_19829295_ChIP-Seq_ESCs_Human1.90997655
17FUS_26573619_Chip-Seq_HEK293_Human1.85323302
18REST_21632747_ChIP-Seq_MESCs_Mouse1.83140453
19EWS_26573619_Chip-Seq_HEK293_Human1.82835701
20TAF15_26573619_Chip-Seq_HEK293_Human1.82061640
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79826211
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78531707
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.73525295
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71088095
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64610020
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61161575
27ER_23166858_ChIP-Seq_MCF-7_Human1.61040495
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.60638430
29RNF2_27304074_Chip-Seq_NSC_Mouse1.57331474
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56533483
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.54168763
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54032264
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53958463
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53958463
35* STAT3_23295773_ChIP-Seq_U87_Human1.51553918
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.51353034
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50010258
38BCAT_22108803_ChIP-Seq_LS180_Human1.49706712
39SMAD4_21799915_ChIP-Seq_A2780_Human1.48957461
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48591239
41AR_25329375_ChIP-Seq_VCAP_Human1.46415876
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.46255140
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44239527
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43814354
45IRF1_19129219_ChIP-ChIP_H3396_Human1.43523975
46TCF4_23295773_ChIP-Seq_U87_Human1.43324257
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43066504
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42968523
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39149799
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38800634
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.36560115
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35442976
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33805187
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32483595
55CBP_20019798_ChIP-Seq_JUKART_Human1.32483595
56AR_21572438_ChIP-Seq_LNCaP_Human1.32474713
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30316371
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30170210
59RUNX2_22187159_ChIP-Seq_PCA_Human1.28919343
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.27893954
61TP53_22573176_ChIP-Seq_HFKS_Human1.26875093
62DROSHA_22980978_ChIP-Seq_HELA_Human1.26505774
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.25944923
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25570003
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24770046
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23316599
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21867125
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20854898
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.19337220
70TCF4_22108803_ChIP-Seq_LS180_Human1.18976326
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15352371
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.13959447
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13820967
74MYC_18940864_ChIP-ChIP_HL60_Human1.13248075
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.12260879
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12260879
77SOX2_19829295_ChIP-Seq_ESCs_Human1.11163106
78NANOG_19829295_ChIP-Seq_ESCs_Human1.11163106
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.10357560
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09909722
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.09903312
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08244050
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08059633
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.06795171
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05340187
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04146658
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03870298
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03267900
89TP53_16413492_ChIP-PET_HCT116_Human1.03206983
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02750722
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02645431
92SMAD3_21741376_ChIP-Seq_ESCs_Human1.00688612
93* NCOR_22424771_ChIP-Seq_293T_Human1.00097258
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99988903
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98183639
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98047572
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.96695863
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.96658327
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.96237834
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.96182070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.33153576
2MP0008877_abnormal_DNA_methylation3.11530443
3MP0000569_abnormal_digit_pigmentation2.76976819
4MP0006292_abnormal_olfactory_placode2.72875053
5MP0009046_muscle_twitch2.53680895
6MP0003136_yellow_coat_color2.23867805
7MP0003880_abnormal_central_pattern2.20169556
8MP0002653_abnormal_ependyma_morphology2.18599715
9MP0001968_abnormal_touch/_nociception2.17341881
10MP0005551_abnormal_eye_electrophysiolog2.15770326
11MP0003195_calcinosis2.12088617
12MP0004133_heterotaxia2.01847472
13MP0006276_abnormal_autonomic_nervous1.97451183
14MP0004142_abnormal_muscle_tone1.96186245
15MP0009745_abnormal_behavioral_response1.94740485
16MP0001485_abnormal_pinna_reflex1.91233513
17MP0002272_abnormal_nervous_system1.85174633
18MP0004885_abnormal_endolymph1.83886549
19MP0001486_abnormal_startle_reflex1.77535093
20MP0002638_abnormal_pupillary_reflex1.77462802
21MP0002736_abnormal_nociception_after1.76853002
22MP0002735_abnormal_chemical_nociception1.69669921
23MP0000778_abnormal_nervous_system1.66490847
24MP0006072_abnormal_retinal_apoptosis1.65219382
25MP0003890_abnormal_embryonic-extraembry1.65192652
26MP0002102_abnormal_ear_morphology1.64808939
27MP0005646_abnormal_pituitary_gland1.64702779
28MP0003121_genomic_imprinting1.64054609
29MP0003646_muscle_fatigue1.60032153
30MP0000427_abnormal_hair_cycle1.58013283
31MP0002064_seizures1.53566912
32MP0003878_abnormal_ear_physiology1.53337235
33MP0005377_hearing/vestibular/ear_phenot1.53337235
34MP0002837_dystrophic_cardiac_calcinosis1.52454199
35MP0004742_abnormal_vestibular_system1.51939242
36MP0008872_abnormal_physiological_respon1.51068919
37MP0002572_abnormal_emotion/affect_behav1.49720881
38MP0001986_abnormal_taste_sensitivity1.49070270
39MP0005423_abnormal_somatic_nervous1.45839334
40MP0003635_abnormal_synaptic_transmissio1.45630592
41MP0000631_abnormal_neuroendocrine_gland1.44796534
42MP0002067_abnormal_sensory_capabilities1.44198780
43MP0009379_abnormal_foot_pigmentation1.43999619
44MP0002557_abnormal_social/conspecific_i1.43505942
45MP0003122_maternal_imprinting1.43360244
46MP0002733_abnormal_thermal_nociception1.43032601
47MP0002160_abnormal_reproductive_system1.41114312
48MP0004043_abnormal_pH_regulation1.40449843
49MP0005645_abnormal_hypothalamus_physiol1.38378223
50MP0001970_abnormal_pain_threshold1.36491026
51MP0002734_abnormal_mechanical_nocicepti1.33952991
52MP0002938_white_spotting1.33762946
53MP0005253_abnormal_eye_physiology1.33626749
54MP0002876_abnormal_thyroid_physiology1.32033701
55MP0004145_abnormal_muscle_electrophysio1.31999169
56MP0002063_abnormal_learning/memory/cond1.31765447
57MP0003011_delayed_dark_adaptation1.31720293
58MP0002928_abnormal_bile_duct1.27325958
59MP0003283_abnormal_digestive_organ1.25490000
60MP0005195_abnormal_posterior_eye1.20833116
61MP0002184_abnormal_innervation1.19711261
62MP0005174_abnormal_tail_pigmentation1.18679818
63MP0008875_abnormal_xenobiotic_pharmacok1.18426867
64MP0002163_abnormal_gland_morphology1.17137299
65MP0001440_abnormal_grooming_behavior1.16294126
66MP0002752_abnormal_somatic_nervous1.15810461
67MP0001905_abnormal_dopamine_level1.15446004
68MP0000026_abnormal_inner_ear1.15384246
69MP0005389_reproductive_system_phenotype1.15050072
70MP0004147_increased_porphyrin_level1.15032056
71MP0008789_abnormal_olfactory_epithelium1.13622618
72MP0000955_abnormal_spinal_cord1.12681128
73MP0001984_abnormal_olfaction1.11886919
74MP0004924_abnormal_behavior1.08541160
75MP0005386_behavior/neurological_phenoty1.08541160
76MP0002882_abnormal_neuron_morphology1.05660067
77MP0003119_abnormal_digestive_system1.02546958
78MP0001293_anophthalmia1.01506812
79MP0001501_abnormal_sleep_pattern1.01449848
80MP0001919_abnormal_reproductive_system1.00369057
81MP0010386_abnormal_urinary_bladder0.99739667
82MP0002095_abnormal_skin_pigmentation0.99419159
83MP0001529_abnormal_vocalization0.98261343
84MP0000049_abnormal_middle_ear0.96551899
85MP0002234_abnormal_pharynx_morphology0.94753488
86MP0005084_abnormal_gallbladder_morpholo0.94188796
87MP0000372_irregular_coat_pigmentation0.93344685
88MP0001963_abnormal_hearing_physiology0.92830415
89MP0001324_abnormal_eye_pigmentation0.92372870
90MP0002909_abnormal_adrenal_gland0.88783823
91MP0005187_abnormal_penis_morphology0.87892859
92MP0002229_neurodegeneration0.87547385
93MP0004859_abnormal_synaptic_plasticity0.86629972
94MP0000230_abnormal_systemic_arterial0.86291155
95MP0005394_taste/olfaction_phenotype0.86071806
96MP0005499_abnormal_olfactory_system0.86071806
97MP0003698_abnormal_male_reproductive0.84591494
98MP0004130_abnormal_muscle_cell0.83143117
99MP0001188_hyperpigmentation0.82902449
100MP0003123_paternal_imprinting0.81996419

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.62978497
2Pancreatic fibrosis (HP:0100732)4.58941510
3Molar tooth sign on MRI (HP:0002419)4.50857394
4Abnormality of midbrain morphology (HP:0002418)4.50857394
5True hermaphroditism (HP:0010459)4.18734640
6Nephronophthisis (HP:0000090)3.82502703
7Congenital stationary night blindness (HP:0007642)3.60292745
8Medial flaring of the eyebrow (HP:0010747)3.59990402
9Hyperventilation (HP:0002883)3.53069129
10Abnormality of the renal medulla (HP:0100957)3.31296840
11Gait imbalance (HP:0002141)3.28013604
12Cystic liver disease (HP:0006706)3.17591590
13Type II lissencephaly (HP:0007260)3.08305767
14Congenital primary aphakia (HP:0007707)3.06201640
15Chronic hepatic failure (HP:0100626)2.93669158
16Nephrogenic diabetes insipidus (HP:0009806)2.87518813
17Progressive cerebellar ataxia (HP:0002073)2.86250138
18Genetic anticipation (HP:0003743)2.84266698
19Abnormality of the renal cortex (HP:0011035)2.80257564
20Tubular atrophy (HP:0000092)2.76511174
21Sclerocornea (HP:0000647)2.75442886
22Protruding tongue (HP:0010808)2.68032870
23Inability to walk (HP:0002540)2.51913054
24Genital tract atresia (HP:0001827)2.51811218
25Vaginal atresia (HP:0000148)2.47904187
26Anencephaly (HP:0002323)2.47703022
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.43895036
28Broad-based gait (HP:0002136)2.42635058
29Abnormality of alanine metabolism (HP:0010916)2.42629918
30Hyperalaninemia (HP:0003348)2.42629918
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42629918
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.42250753
33Congenital, generalized hypertrichosis (HP:0004540)2.41216317
34Lissencephaly (HP:0001339)2.40842931
35Congenital hepatic fibrosis (HP:0002612)2.38815858
36Poor coordination (HP:0002370)2.36898927
37Polydipsia (HP:0001959)2.36176137
38Abnormal drinking behavior (HP:0030082)2.36176137
39Abolished electroretinogram (ERG) (HP:0000550)2.32695916
40Furrowed tongue (HP:0000221)2.31565100
41Cerebellar dysplasia (HP:0007033)2.30570671
42Male pseudohermaphroditism (HP:0000037)2.28814647
43Absent/shortened dynein arms (HP:0200106)2.28374346
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.28374346
45Attenuation of retinal blood vessels (HP:0007843)2.24051954
46Rib fusion (HP:0000902)2.23126487
47Gaze-evoked nystagmus (HP:0000640)2.22649479
48Patellar aplasia (HP:0006443)2.22175796
49Abnormal rod and cone electroretinograms (HP:0008323)2.20732144
50Large for gestational age (HP:0001520)2.19391332
51Pendular nystagmus (HP:0012043)2.14111352
52Postaxial foot polydactyly (HP:0001830)2.11851351
53Aplasia/Hypoplasia of the patella (HP:0006498)2.11684551
54Birth length less than 3rd percentile (HP:0003561)2.06655644
55Clumsiness (HP:0002312)2.05039370
56Optic nerve hypoplasia (HP:0000609)2.02454457
57Bony spicule pigmentary retinopathy (HP:0007737)2.00529558
58Drooling (HP:0002307)1.98693338
59Febrile seizures (HP:0002373)1.96251767
60Abnormal respiratory motile cilium morphology (HP:0005938)1.94257484
61Abnormal respiratory epithelium morphology (HP:0012253)1.94257484
62Hypoplastic ischia (HP:0003175)1.94207464
63Polyuria (HP:0000103)1.93202746
64Keratoconus (HP:0000563)1.92091847
65Increased corneal curvature (HP:0100692)1.92091847
66Concave nail (HP:0001598)1.92015766
67Pachygyria (HP:0001302)1.91842131
68Abnormal ciliary motility (HP:0012262)1.91727680
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89987559
70Anophthalmia (HP:0000528)1.88926753
71Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87769019
72Preaxial hand polydactyly (HP:0001177)1.86098270
73Oligodactyly (hands) (HP:0001180)1.85041279
74Decreased circulating renin level (HP:0003351)1.83940365
75Postaxial hand polydactyly (HP:0001162)1.83589997
76Absent speech (HP:0001344)1.83409605
77Agitation (HP:0000713)1.83300042
78Left ventricular hypertrophy (HP:0001712)1.81763941
79Abnormal pancreas size (HP:0012094)1.81138516
80Aganglionic megacolon (HP:0002251)1.80896947
81Tachypnea (HP:0002789)1.80407917
82Progressive inability to walk (HP:0002505)1.79499382
83Specific learning disability (HP:0001328)1.76679407
84Thyroid-stimulating hormone excess (HP:0002925)1.76277638
85Hypoplasia of the pons (HP:0012110)1.76044913
86Excessive salivation (HP:0003781)1.75655631
87Focal motor seizures (HP:0011153)1.75393440
88Focal seizures (HP:0007359)1.75336950
89Fair hair (HP:0002286)1.75185347
90Bile duct proliferation (HP:0001408)1.74930561
91Abnormal biliary tract physiology (HP:0012439)1.74930561
92Decreased central vision (HP:0007663)1.74407338
93Narrow forehead (HP:0000341)1.74088661
94Dandy-Walker malformation (HP:0001305)1.74062360
95Severe muscular hypotonia (HP:0006829)1.73763941
96Short foot (HP:0001773)1.73733217
97Abnormality of the labia minora (HP:0012880)1.73592769
98Occipital encephalocele (HP:0002085)1.73033910
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.71075406
100Polyphagia (HP:0002591)1.70603366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.54907250
2ADRBK23.30749403
3CASK3.11318589
4BMPR1B2.82193080
5GRK12.49106045
6ACVR1B2.44706533
7WNK42.28951578
8PNCK2.22758426
9WNK32.18982575
10TAOK32.15531649
11NTRK32.15226686
12PINK12.10727790
13MAP3K42.05478083
14ZAK2.00274281
15INSRR1.94532072
16NUAK11.93841449
17MARK11.88743320
18MAPK131.85274606
19MAP4K21.81638363
20TLK11.77448944
21OXSR11.56660639
22MAP2K71.51911318
23DYRK21.41540116
24SIK21.36729766
25PAK31.34053854
26PIK3CA1.28260964
27STK391.26423016
28ADRBK11.26305481
29NTRK21.21433859
30TNIK1.19603861
31PRKCG1.17070563
32MAPK151.16646242
33CDK191.16573416
34MKNK21.14751598
35DAPK21.12898418
36TGFBR10.92451913
37TIE10.90723932
38EPHA40.86472664
39CAMKK20.82536614
40PRKCE0.79897911
41TYRO30.79126368
42CAMK1G0.78239860
43STK160.78155711
44CSNK1G20.76148177
45CAMK10.70690175
46STK30.69113203
47WNK10.68877524
48SGK2230.68810899
49SGK4940.68810899
50TRIM280.68702017
51MAP2K40.66017728
52SGK20.65924085
53MINK10.64242987
54PTK2B0.63284564
55PHKG20.63212422
56PHKG10.63212422
57STK110.63115674
58PKN10.61085940
59CAMK1D0.59739661
60AKT30.59638838
61CAMK2A0.59123120
62EPHB20.58997802
63MUSK0.58222277
64PLK20.58055988
65PLK40.57785266
66NEK20.57317052
67PRKACA0.55611766
68CHUK0.54765529
69TEC0.53385301
70CSNK1G10.52939146
71IRAK10.52422299
72VRK10.52161073
73PRKCQ0.51422009
74BCR0.50949215
75CSNK1G30.49773289
76OBSCN0.47516429
77RPS6KA50.46976791
78RPS6KA60.46714380
79TXK0.46158957
80PRKCZ0.45258095
81MAP3K90.44506503
82STK38L0.44251586
83CSNK1E0.43626485
84DYRK1A0.42311165
85CSNK1A10.42310452
86CSNK1A1L0.41887010
87PRKCH0.40463999
88PRKAA10.40312146
89CDC70.38654999
90SGK10.38575374
91PRKG10.37921298
92MAP2K60.37576243
93ERBB20.37493316
94PLK10.36732046
95CSNK1D0.36323514
96CDK50.35570455
97BCKDK0.34148169
98DYRK30.33989449
99PRKCA0.32913541
100PRKACB0.32582349

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.96300048
2Phototransduction_Homo sapiens_hsa047442.88166214
3Linoleic acid metabolism_Homo sapiens_hsa005912.61742601
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.47620450
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46240717
6Selenocompound metabolism_Homo sapiens_hsa004502.36573075
7Butanoate metabolism_Homo sapiens_hsa006502.34352682
8Nitrogen metabolism_Homo sapiens_hsa009102.19519474
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17583916
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12098399
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09640861
12Oxidative phosphorylation_Homo sapiens_hsa001902.03597462
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.94606014
14Ether lipid metabolism_Homo sapiens_hsa005651.83348432
15Morphine addiction_Homo sapiens_hsa050321.80826117
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77695919
17Cardiac muscle contraction_Homo sapiens_hsa042601.75922755
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.74312884
19Taste transduction_Homo sapiens_hsa047421.70941201
20Tryptophan metabolism_Homo sapiens_hsa003801.65168093
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59413025
22Homologous recombination_Homo sapiens_hsa034401.57281250
23Olfactory transduction_Homo sapiens_hsa047401.56627986
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54129814
25Parkinsons disease_Homo sapiens_hsa050121.52392390
26Glutamatergic synapse_Homo sapiens_hsa047241.46688156
27Insulin secretion_Homo sapiens_hsa049111.46388165
28Fanconi anemia pathway_Homo sapiens_hsa034601.45732095
29Circadian entrainment_Homo sapiens_hsa047131.44059502
30GABAergic synapse_Homo sapiens_hsa047271.40147152
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33829079
32Serotonergic synapse_Homo sapiens_hsa047261.30318431
33Protein export_Homo sapiens_hsa030601.29477123
34Caffeine metabolism_Homo sapiens_hsa002321.23277670
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.22778315
36ABC transporters_Homo sapiens_hsa020101.20737951
37Chemical carcinogenesis_Homo sapiens_hsa052041.15500604
38Huntingtons disease_Homo sapiens_hsa050161.14832212
39Basal transcription factors_Homo sapiens_hsa030221.14237316
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13799856
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.13302975
42RNA polymerase_Homo sapiens_hsa030201.12486886
43Dopaminergic synapse_Homo sapiens_hsa047281.10407176
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07400028
45Ribosome_Homo sapiens_hsa030101.05549773
46Peroxisome_Homo sapiens_hsa041461.04974379
47Alzheimers disease_Homo sapiens_hsa050101.03819177
48Retinol metabolism_Homo sapiens_hsa008300.98898736
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97572033
50Cocaine addiction_Homo sapiens_hsa050300.94737830
51Propanoate metabolism_Homo sapiens_hsa006400.94089348
52Arachidonic acid metabolism_Homo sapiens_hsa005900.93220716
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92053748
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90762730
55Regulation of autophagy_Homo sapiens_hsa041400.88849519
56Ovarian steroidogenesis_Homo sapiens_hsa049130.88705914
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86214435
58Long-term depression_Homo sapiens_hsa047300.85335056
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85214425
60Glycerolipid metabolism_Homo sapiens_hsa005610.84499595
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83747074
62RNA degradation_Homo sapiens_hsa030180.82748004
63Fat digestion and absorption_Homo sapiens_hsa049750.81964386
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.81753033
65Cholinergic synapse_Homo sapiens_hsa047250.80929936
66Histidine metabolism_Homo sapiens_hsa003400.80408338
67Calcium signaling pathway_Homo sapiens_hsa040200.80179192
68Salivary secretion_Homo sapiens_hsa049700.79836894
69Axon guidance_Homo sapiens_hsa043600.78502894
70Dorso-ventral axis formation_Homo sapiens_hsa043200.77466700
71beta-Alanine metabolism_Homo sapiens_hsa004100.73413928
72Hedgehog signaling pathway_Homo sapiens_hsa043400.71386550
73Gastric acid secretion_Homo sapiens_hsa049710.71325735
74Basal cell carcinoma_Homo sapiens_hsa052170.69805043
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.69541934
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63717719
77Oxytocin signaling pathway_Homo sapiens_hsa049210.60045954
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58217557
79cAMP signaling pathway_Homo sapiens_hsa040240.57334824
80Amphetamine addiction_Homo sapiens_hsa050310.56734571
81Collecting duct acid secretion_Homo sapiens_hsa049660.53860918
82Steroid biosynthesis_Homo sapiens_hsa001000.52239405
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50349965
84Hippo signaling pathway_Homo sapiens_hsa043900.48898338
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48823043
86Metabolic pathways_Homo sapiens_hsa011000.48162231
87One carbon pool by folate_Homo sapiens_hsa006700.47172389
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43506416
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41894622
90Sulfur relay system_Homo sapiens_hsa041220.41421211
91Mineral absorption_Homo sapiens_hsa049780.41281701
92Purine metabolism_Homo sapiens_hsa002300.38504061
93Fatty acid biosynthesis_Homo sapiens_hsa000610.36480926
94Pancreatic secretion_Homo sapiens_hsa049720.35559741
95Fatty acid degradation_Homo sapiens_hsa000710.33561986
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33038720
97Bile secretion_Homo sapiens_hsa049760.32345143
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.32227711
99MAPK signaling pathway_Homo sapiens_hsa040100.31015399
100Ras signaling pathway_Homo sapiens_hsa040140.30659045

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »