SPINK8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.83439951
2regulation of acrosome reaction (GO:0060046)8.77850073
3spermatid nucleus differentiation (GO:0007289)8.45809493
4positive regulation of antigen processing and presentation (GO:0002579)7.31589522
5plasma membrane fusion (GO:0045026)7.07161371
6acrosome assembly (GO:0001675)6.65895825
7regulation of macrophage chemotaxis (GO:0010758)6.31651575
8auditory receptor cell differentiation (GO:0042491)6.29452186
9regulation of clathrin-mediated endocytosis (GO:2000369)5.92844941
10regulation of antigen processing and presentation (GO:0002577)5.86468858
11vascular smooth muscle contraction (GO:0014829)5.67803382
12positive regulation of mitochondrial calcium ion concentration (GO:0051561)5.46819134
13positive regulation of steroid hormone secretion (GO:2000833)5.40190792
14establishment of epithelial cell polarity (GO:0090162)5.32364877
15complement activation, alternative pathway (GO:0006957)5.13760290
16developmental pigmentation (GO:0048066)4.80354677
17endocrine hormone secretion (GO:0060986)4.76726906
18energy homeostasis (GO:0097009)4.75210195
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.73132764
20neural tube formation (GO:0001841)4.65795946
21cerebral cortex radially oriented cell migration (GO:0021799)4.54313505
22embryonic heart tube development (GO:0035050)4.48863870
23cellular sodium ion homeostasis (GO:0006883)4.45485021
24Leydig cell differentiation (GO:0033327)4.38515207
25presynaptic membrane assembly (GO:0097105)4.37696343
26retinal ganglion cell axon guidance (GO:0031290)4.37690230
27iron coordination entity transport (GO:1901678)4.36772148
28zinc ion transport (GO:0006829)4.27170069
29glycine transport (GO:0015816)4.22732246
30mRNA transcription from RNA polymerase II promoter (GO:0042789)4.21652630
31positive regulation of hair cycle (GO:0042635)4.19066811
32positive regulation of hair follicle development (GO:0051798)4.19066811
33limb bud formation (GO:0060174)4.17252810
34regulation of steroid hormone secretion (GO:2000831)4.13937439
35angiogenesis involved in wound healing (GO:0060055)4.11218917
36positive regulation of skeletal muscle tissue development (GO:0048643)4.08884893
37SMAD protein complex assembly (GO:0007183)4.00683568
38regulation of calcium ion-dependent exocytosis (GO:0017158)3.91256990
39bone trabecula formation (GO:0060346)3.88693638
40urate metabolic process (GO:0046415)3.81220479
41negative regulation of systemic arterial blood pressure (GO:0003085)3.77331771
42embryonic process involved in female pregnancy (GO:0060136)3.77263305
43drug transmembrane transport (GO:0006855)3.63200945
44retinal cone cell development (GO:0046549)3.60952748
45embryonic foregut morphogenesis (GO:0048617)3.60943618
46positive regulation of cellular response to oxidative stress (GO:1900409)3.59739281
47positive regulation of response to oxidative stress (GO:1902884)3.59739281
48negative regulation of receptor-mediated endocytosis (GO:0048261)3.54496019
49cytolysis (GO:0019835)3.50694703
50ganglion development (GO:0061548)3.48227065
51inner ear receptor cell differentiation (GO:0060113)3.47764892
52retrograde transport, vesicle recycling within Golgi (GO:0000301)3.46353260
53presynaptic membrane organization (GO:0097090)3.44524262
54regulation of sarcomere organization (GO:0060297)3.41705450
55execution phase of apoptosis (GO:0097194)3.41464651
56hair cell differentiation (GO:0035315)3.40676500
57mRNA transcription (GO:0009299)3.40558769
58piRNA metabolic process (GO:0034587)3.36482084
59positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.35325252
60hypotonic response (GO:0006971)3.33459026
61response to folic acid (GO:0051593)3.32866613
62response to parathyroid hormone (GO:0071107)3.32718876
63lymphangiogenesis (GO:0001946)3.31064849
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.30708794
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30708794
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30708794
67cell migration involved in gastrulation (GO:0042074)3.27793012
68phosphorelay signal transduction system (GO:0000160)3.26481836
69regulation of hydrogen peroxide metabolic process (GO:0010310)3.25523754
70filopodium assembly (GO:0046847)3.23920022
71cardiac ventricle formation (GO:0003211)3.19909701
72sulfur amino acid catabolic process (GO:0000098)3.17738133
73regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.17216006
74establishment of protein localization to Golgi (GO:0072600)3.16948782
75protein targeting to Golgi (GO:0000042)3.15827808
76epithelial cell differentiation involved in kidney development (GO:0035850)3.15083295
77glial cell proliferation (GO:0014009)3.12766280
78macroautophagy (GO:0016236)3.12661222
79photoreceptor cell differentiation (GO:0046530)3.09762198
80eye photoreceptor cell differentiation (GO:0001754)3.09762198
81neural crest cell development (GO:0014032)3.09726046
82interkinetic nuclear migration (GO:0022027)3.08804208
83cornea development in camera-type eye (GO:0061303)3.05774869
84regulation of MHC class I biosynthetic process (GO:0045343)3.05662080
85regulation of complement activation (GO:0030449)3.05637082
86regulation of meiosis I (GO:0060631)3.03502484
87positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.01203015
88cell morphogenesis involved in neuron differentiation (GO:0048667)2.98081278
89regulation of mesoderm development (GO:2000380)2.97391573
90phospholipid homeostasis (GO:0055091)2.94667636
91regulation of protein activation cascade (GO:2000257)2.91014847
92cardiac chamber formation (GO:0003207)2.89246667
93cyclooxygenase pathway (GO:0019371)2.89196329
94mitochondrial calcium ion homeostasis (GO:0051560)2.88459358
95seminiferous tubule development (GO:0072520)2.86981280
96hepatocyte apoptotic process (GO:0097284)2.85059708
97labyrinthine layer development (GO:0060711)2.84811625
98negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.84677480
99lamellipodium assembly (GO:0030032)2.83325891
100platelet dense granule organization (GO:0060155)2.82543066
101sodium ion homeostasis (GO:0055078)2.81751489
102positive regulation of vasculogenesis (GO:2001214)2.80058885
103negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.78313672
104negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77556543
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.72083569
106regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.71282671
107cerebral cortex cell migration (GO:0021795)2.68369729
108tonic smooth muscle contraction (GO:0014820)2.68265358
109alpha-linolenic acid metabolic process (GO:0036109)2.67823725
110endoderm formation (GO:0001706)2.67224047
111nerve growth factor signaling pathway (GO:0038180)2.65251951
112positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.64471011
113cellular response to electrical stimulus (GO:0071257)2.64111052
114serotonin metabolic process (GO:0042428)2.63966560
115negative regulation of calcium ion transport into cytosol (GO:0010523)2.62427225
116regulation of T cell tolerance induction (GO:0002664)2.61741191
117negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.61423468
118regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.61321944
119kynurenine metabolic process (GO:0070189)2.61197694
120transcytosis (GO:0045056)2.59535516
121pyrimidine ribonucleoside catabolic process (GO:0046133)2.56149120
122termination of G-protein coupled receptor signaling pathway (GO:0038032)2.55815305
123phenol-containing compound catabolic process (GO:0019336)2.55631315
124sialylation (GO:0097503)2.54773149
125artery smooth muscle contraction (GO:0014824)2.53799905
126regulation of female gonad development (GO:2000194)2.53193359
127endothelium development (GO:0003158)2.52858761
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.52052000
129ionotropic glutamate receptor signaling pathway (GO:0035235)2.52031042
130lamellipodium organization (GO:0097581)2.50542232
131negative regulation of leukocyte chemotaxis (GO:0002689)2.50033135
132regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40012969
133glutamate receptor signaling pathway (GO:0007215)2.39108577
134metanephric tubule development (GO:0072170)2.37823920
135metanephric nephron tubule development (GO:0072234)2.37823920
136cochlea development (GO:0090102)2.37780544
137cellular response to ATP (GO:0071318)2.37176739
138gamma-aminobutyric acid signaling pathway (GO:0007214)2.36740083
139protein maturation by protein folding (GO:0022417)2.36549999
140regulation of Rac GTPase activity (GO:0032314)2.35670282
141cellular response to epinephrine stimulus (GO:0071872)2.35311009
142primary amino compound metabolic process (GO:1901160)2.34436890
143innervation (GO:0060384)2.33218215
144response to misfolded protein (GO:0051788)2.30871418
145inner ear receptor cell development (GO:0060119)2.30605398
146regulation of Cdc42 GTPase activity (GO:0043088)2.29613269
147positive regulation of filopodium assembly (GO:0051491)2.28234483
148cellular copper ion homeostasis (GO:0006878)2.27372572
149galactose catabolic process (GO:0019388)2.25916231
150negative regulation of amino acid transport (GO:0051956)2.24649346
151fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.23279985
152regulation of glutamate secretion (GO:0014048)2.22704475
153phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.21058161
154adaptation of signaling pathway (GO:0023058)2.19540933
155metanephric nephron epithelium development (GO:0072243)2.19094575
156extracellular fibril organization (GO:0043206)2.19005318
157regulation of neuron projection regeneration (GO:0070570)2.18313045
158regulation of axon regeneration (GO:0048679)2.18313045
159positive regulation of tolerance induction (GO:0002645)2.13220032
160neutral lipid catabolic process (GO:0046461)2.13109024
161acylglycerol catabolic process (GO:0046464)2.13109024
162heme transport (GO:0015886)2.12910914
163vocalization behavior (GO:0071625)2.12283675
164extracellular matrix assembly (GO:0085029)2.10448488
165long term synaptic depression (GO:0060292)2.10384708
166L-serine transport (GO:0015825)2.09520846
167triglyceride catabolic process (GO:0019433)2.09384114
168complement activation, classical pathway (GO:0006958)2.09031138
169behavioral defense response (GO:0002209)2.08693626
170behavioral fear response (GO:0001662)2.08693626
171long-term memory (GO:0007616)2.07643319
172linoleic acid metabolic process (GO:0043651)2.07089224
173valine metabolic process (GO:0006573)2.05000792
174regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.04898259
175protein localization to synapse (GO:0035418)2.04735490
176negative regulation of smooth muscle contraction (GO:0045986)2.04629428
177GPI anchor metabolic process (GO:0006505)2.03091638
178response to histamine (GO:0034776)2.02761612
179relaxation of smooth muscle (GO:0044557)2.02576321
180nucleoside diphosphate catabolic process (GO:0009134)2.02066662
181GPI anchor biosynthetic process (GO:0006506)2.02054225
182neuron recognition (GO:0008038)2.01282937
183antigen processing and presentation of endogenous peptide antigen (GO:0002483)16.7973763
184antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)16.7973763
185antigen processing and presentation via MHC class Ib (GO:0002475)16.1819702
186regulation of antigen processing and presentation of peptide antigen (GO:0002583)15.3261297
187detection of temperature stimulus involved in sensory perception (GO:0050961)14.3903967
188detection of temperature stimulus involved in sensory perception of pain (GO:0050965)14.3903967
189antigen processing and presentation of endogenous antigen (GO:0019883)13.9196355
190detection of temperature stimulus (GO:0016048)10.3802103
191long-term synaptic potentiation (GO:0060291)1.98718432
192establishment of nucleus localization (GO:0040023)1.98374807
193negative regulation of metanephros development (GO:0072217)1.98002754
194regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)1.97720381
195positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.96868781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human9.20845383
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.70582058
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.37293956
4EZH2_22144423_ChIP-Seq_EOC_Human3.33976573
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80487365
6AR_21572438_ChIP-Seq_LNCaP_Human2.65000089
7GBX2_23144817_ChIP-Seq_PC3_Human2.64491029
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.42618192
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36805709
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32909436
11IGF1R_20145208_ChIP-Seq_DFB_Human2.31946148
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29590163
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28386374
14ZNF274_21170338_ChIP-Seq_K562_Hela2.18610703
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16321255
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13033818
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11141239
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07422296
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.06203331
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.05882632
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.05882632
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.05882632
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03293152
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03123116
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03123116
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02208204
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.99250807
28TAF15_26573619_Chip-Seq_HEK293_Human1.90880114
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.88468755
30TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88468755
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.88118625
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.82757733
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80621311
34SMAD4_21799915_ChIP-Seq_A2780_Human1.79620295
35EWS_26573619_Chip-Seq_HEK293_Human1.79210096
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78688694
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77102988
38RNF2_27304074_Chip-Seq_NSC_Mouse1.74806146
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71463216
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71090664
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70859585
42HTT_18923047_ChIP-ChIP_STHdh_Human1.70581157
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.70145668
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66120935
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64659456
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64224980
47* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61345109
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60109203
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.57644101
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.55347820
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.54981436
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54534515
53ZNF263_19887448_ChIP-Seq_K562_Human1.52911057
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52755355
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.50995853
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.46394498
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45613456
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45336851
59BCAT_22108803_ChIP-Seq_LS180_Human1.43626086
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.42634495
61SOX2_19829295_ChIP-Seq_ESCs_Human1.39564886
62NANOG_19829295_ChIP-Seq_ESCs_Human1.39564886
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.39562199
64AHR_22903824_ChIP-Seq_MCF-7_Human1.39529120
65CLOCK_20551151_ChIP-Seq_293T_Human1.39207104
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.38928073
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.38625914
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37897462
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35315412
70VDR_24787735_ChIP-Seq_THP-1_Human1.33867049
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32740167
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31554948
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31407477
74DROSHA_22980978_ChIP-Seq_HELA_Human1.30426972
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29482741
76REST_21632747_ChIP-Seq_MESCs_Mouse1.29232985
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28991329
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.28773722
79TP53_22573176_ChIP-Seq_HFKS_Human1.28353294
80TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28039455
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27994609
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27353020
83P300_19829295_ChIP-Seq_ESCs_Human1.27186822
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.26041912
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.24345103
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.23218106
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22982240
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22916334
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.22538602
90TP53_16413492_ChIP-PET_HCT116_Human1.20034228
91ETV1_20927104_ChIP-Seq_GIST48_Human1.19801111
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19395232
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17712533
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17633280
95ER_23166858_ChIP-Seq_MCF-7_Human1.17579662
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17146953
97TCF4_22108803_ChIP-Seq_LS180_Human1.17103321
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16570128
99VDR_22108803_ChIP-Seq_LS180_Human1.16391404
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16371005
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.15689851
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14443383
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14233070
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13882203
105RARB_27405468_Chip-Seq_BRAIN_Mouse1.13722961
106RUNX2_22187159_ChIP-Seq_PCA_Human1.13704198
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13628649
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13599731
109AR_25329375_ChIP-Seq_VCAP_Human1.13246326
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.13170504
111P53_22387025_ChIP-Seq_ESCs_Mouse1.12440935
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11549734
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.11171357
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.11021637
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.09536462
116NFYB_21822215_ChIP-Seq_K562_Human1.09254199
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.08767458
118TBL1_22424771_ChIP-Seq_293T_Human1.08737396
119CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07695341
120ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07471758
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07298791
122LXR_22158963_ChIP-Seq_LIVER_Mouse1.07020169
123TP53_18474530_ChIP-ChIP_U2OS_Human1.06568043
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06341211
125KDM2B_26808549_Chip-Seq_REH_Human1.06222019
126* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05564726
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05328857
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.05034250
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04764418
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04541123
131SMAD3_21741376_ChIP-Seq_HESCs_Human1.03897075
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.02997945
133MYC_19915707_ChIP-ChIP_AK7_Human1.01757509
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.01409190
135POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00098969
136* TCF4_23295773_ChIP-Seq_U87_Human0.99629492
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.99265784
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98674251
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97025346
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97025346
141ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96522793
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.96324723
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96290579
144CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95863842
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90798044
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89280019
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88930026
148FUS_26573619_Chip-Seq_HEK293_Human0.88473318
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88320952
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87687718
151RING1B_27294783_Chip-Seq_ESCs_Mouse0.87640698
152JUN_21703547_ChIP-Seq_K562_Human0.87595473
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87238962
154SOX2_20726797_ChIP-Seq_SW620_Human0.86919673
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.86302610
156AR_19668381_ChIP-Seq_PC3_Human0.85978385
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85635663
158WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85553043
159WT1_19549856_ChIP-ChIP_CCG9911_Human0.85031181
160RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84748437
161STAT3_23295773_ChIP-Seq_U87_Human0.82922012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.39923207
2MP0005167_abnormal_blood-brain_barrier3.95771828
3MP0002837_dystrophic_cardiac_calcinosis3.83447853
4MP0004859_abnormal_synaptic_plasticity3.56003200
5MP0010386_abnormal_urinary_bladder3.49859093
6MP0004742_abnormal_vestibular_system3.07277914
7MP0001879_abnormal_lymphatic_vessel3.02937311
8MP0003718_maternal_effect3.02261409
9MP0002736_abnormal_nociception_after2.93699839
10MP0002938_white_spotting2.90680364
11MP0004270_analgesia2.81853133
12MP0001919_abnormal_reproductive_system2.73508814
13MP0001501_abnormal_sleep_pattern2.73052960
14MP0010234_abnormal_vibrissa_follicle2.63812763
15MP0001968_abnormal_touch/_nociception2.45732657
16MP0005646_abnormal_pituitary_gland2.39758402
17MP0005058_abnormal_lysosome_morphology2.39290455
18MP0003635_abnormal_synaptic_transmissio2.28984479
19MP0002876_abnormal_thyroid_physiology2.27935114
20MP0008877_abnormal_DNA_methylation2.26759466
21MP0008004_abnormal_stomach_pH2.23829191
22MP0002160_abnormal_reproductive_system2.16913068
23MP0001765_abnormal_ion_homeostasis2.09856419
24MP0009780_abnormal_chondrocyte_physiolo2.03348674
25MP0003329_amyloid_beta_deposits2.02526787
26MP0002063_abnormal_learning/memory/cond1.99705712
27MP0004264_abnormal_extraembryonic_tissu1.97784059
28MP0005551_abnormal_eye_electrophysiolog1.94701846
29MP0001440_abnormal_grooming_behavior1.93425494
30MP0002127_abnormal_cardiovascular_syste1.93226965
31MP0005084_abnormal_gallbladder_morpholo1.86858404
32MP0003787_abnormal_imprinting1.85745983
33MP0009745_abnormal_behavioral_response1.83457349
34MP0005410_abnormal_fertilization1.81472449
35MP0004858_abnormal_nervous_system1.78203204
36MP0003300_gastrointestinal_ulcer1.75378981
37MP0005389_reproductive_system_phenotype1.74469744
38MP0003045_fibrosis1.73684460
39MP0001485_abnormal_pinna_reflex1.72192404
40MP0005275_abnormal_skin_tensile1.65853629
41MP0004147_increased_porphyrin_level1.64323123
42MP0002735_abnormal_chemical_nociception1.63903278
43MP0002572_abnormal_emotion/affect_behav1.60784360
44MP0005395_other_phenotype1.60215579
45MP0003724_increased_susceptibility_to1.58848333
46MP0002396_abnormal_hematopoietic_system1.57082436
47MP0002254_reproductive_system_inflammat1.55061031
48MP0003011_delayed_dark_adaptation1.53223736
49MP0004036_abnormal_muscle_relaxation1.51778335
50MP0001664_abnormal_digestion1.51687669
51MP0005666_abnormal_adipose_tissue1.51645474
52MP0004134_abnormal_chest_morphology1.51279729
53MP0000604_amyloidosis1.47180148
54MP0005377_hearing/vestibular/ear_phenot1.45352243
55MP0003878_abnormal_ear_physiology1.45352243
56MP0005375_adipose_tissue_phenotype1.42563022
57MP0002064_seizures1.40878124
58MP0002139_abnormal_hepatobiliary_system1.39558894
59MP0002272_abnormal_nervous_system1.39399307
60MP0004130_abnormal_muscle_cell1.35642101
61MP0004215_abnormal_myocardial_fiber1.32929220
62MP0005636_abnormal_mineral_homeostasis1.32791126
63MP0005670_abnormal_white_adipose1.32769760
64MP0000751_myopathy1.31722612
65MP0008260_abnormal_autophagy1.31625344
66MP0009379_abnormal_foot_pigmentation1.30349726
67MP0008438_abnormal_cutaneous_collagen1.29455255
68MP0010329_abnormal_lipoprotein_level1.28699510
69MP0000013_abnormal_adipose_tissue1.27976513
70MP0000230_abnormal_systemic_arterial1.26689579
71MP0003075_altered_response_to1.25388315
72MP0003890_abnormal_embryonic-extraembry1.25328507
73MP0001756_abnormal_urination1.25274228
74MP0002009_preneoplasia1.24417506
75MP0000538_abnormal_urinary_bladder1.24392148
76MP0009785_altered_susceptibility_to1.24211083
77MP0004885_abnormal_endolymph1.23680604
78MP0009697_abnormal_copulation1.22961047
79MP0003119_abnormal_digestive_system1.21315694
80MP0002909_abnormal_adrenal_gland1.20189909
81MP0000003_abnormal_adipose_tissue1.19215053
82MP0002210_abnormal_sex_determination1.18662993
83MP0004145_abnormal_muscle_electrophysio1.18474136
84MP0005330_cardiomyopathy1.17498478
85MP0006072_abnormal_retinal_apoptosis1.17048147
86MP0005085_abnormal_gallbladder_physiolo1.16048501
87MP0002332_abnormal_exercise_endurance1.14908149
88MP0004043_abnormal_pH_regulation1.14818803
89MP0002138_abnormal_hepatobiliary_system1.13634885
90MP0005620_abnormal_muscle_contractility1.13116017
91MP0005535_abnormal_body_temperature1.11566313
92MP0003195_calcinosis1.11160969
93MP0002733_abnormal_thermal_nociception1.11126607
94MP0008875_abnormal_xenobiotic_pharmacok1.10237661
95MP0002295_abnormal_pulmonary_circulatio1.09985552
96MP0004185_abnormal_adipocyte_glucose1.09897044
97MP0004484_altered_response_of1.08618186
98MP0000750_abnormal_muscle_regeneration1.07265280
99MP0003191_abnormal_cellular_cholesterol1.07199056
100MP0001970_abnormal_pain_threshold1.07014902
101MP0001929_abnormal_gametogenesis1.05456002
102MP0001764_abnormal_homeostasis1.03964346
103MP0000462_abnormal_digestive_system1.03375689
104MP0003303_peritoneal_inflammation1.03141447
105MP0000613_abnormal_salivary_gland1.01088429
106MP0005164_abnormal_response_to1.00812227
107MP0000569_abnormal_digit_pigmentation1.00644725
108MP0000631_abnormal_neuroendocrine_gland1.00423488
109MP0002168_other_aberrant_phenotype0.99013767
110MP0010368_abnormal_lymphatic_system0.97703568
111MP0003879_abnormal_hair_cell0.97170816
112MP0001486_abnormal_startle_reflex0.96040282
113MP0008995_early_reproductive_senescence0.94191251
114MP0005367_renal/urinary_system_phenotyp0.93177324
115MP0000516_abnormal_urinary_system0.93177324
116MP0000767_abnormal_smooth_muscle0.92743463
117MP0004019_abnormal_vitamin_homeostasis0.92125500
118MP0002166_altered_tumor_susceptibility0.91712569
119MP0001958_emphysema0.91212329
120MP0000653_abnormal_sex_gland0.89030478
121MP0002067_abnormal_sensory_capabilities0.88875009
122MP0005332_abnormal_amino_acid0.88099020
123MP0003828_pulmonary_edema0.87529910
124MP0003385_abnormal_body_wall0.87396326
125MP0005166_decreased_susceptibility_to0.87092417
126MP0001502_abnormal_circadian_rhythm0.86964736
127MP0002557_abnormal_social/conspecific_i0.86651071
128MP0001177_atelectasis0.86304188
129MP0003632_abnormal_nervous_system0.85222553
130MP0002751_abnormal_autonomic_nervous0.84597673
131MP0005253_abnormal_eye_physiology0.83778014
132MP0000778_abnormal_nervous_system0.82656973
133MP0005408_hypopigmentation0.82515028
134MP0000249_abnormal_blood_vessel0.80965360
135MP0006276_abnormal_autonomic_nervous0.80741095
136MP0006138_congestive_heart_failure0.78203631
137MP0000537_abnormal_urethra_morphology0.77637069
138MP0004883_abnormal_blood_vessel0.77535861
139MP0000733_abnormal_muscle_development0.77048744
140MP0002102_abnormal_ear_morphology0.76757385
141MP0005381_digestive/alimentary_phenotyp0.76579685
142MP0002118_abnormal_lipid_homeostasis0.76531465
143MP0002928_abnormal_bile_duct0.75826110
144MP0003935_abnormal_craniofacial_develop0.75820763
145MP0005365_abnormal_bile_salt0.75623283
146MP0002282_abnormal_trachea_morphology0.75152356
147MP0003631_nervous_system_phenotype0.75149024
148MP0005409_darkened_coat_color0.74954517
149MP0008874_decreased_physiological_sensi0.74864388
150MP0008057_abnormal_DNA_replication0.74697335
151MP0005360_urolithiasis0.74406902
152MP0002734_abnormal_mechanical_nocicepti0.74071657
153MP0000026_abnormal_inner_ear0.73954235
154MP0001145_abnormal_male_reproductive0.73831084
155MP0002234_abnormal_pharynx_morphology0.73763855
156MP0005645_abnormal_hypothalamus_physiol0.73416461
157MP0003121_genomic_imprinting0.71916890
158MP0002069_abnormal_eating/drinking_beha0.70485164
159MP0002925_abnormal_cardiovascular_devel0.70416486
160MP0003705_abnormal_hypodermis_morpholog0.70093904
161MP0003690_abnormal_glial_cell0.69670786
162MP0003943_abnormal_hepatobiliary_system0.69551992
163MP0003941_abnormal_skin_development0.69326674
164MP0002128_abnormal_blood_circulation0.68883714
165MP0004272_abnormal_basement_membrane0.68055298
166MP0008872_abnormal_physiological_respon0.67871841
167MP0003638_abnormal_response/metabolism_0.67353712
168MP0003938_abnormal_ear_development0.67192110
169MP0005385_cardiovascular_system_phenoty0.66930955
170MP0001544_abnormal_cardiovascular_syste0.66930955
171MP0002184_abnormal_innervation0.65337575
172MP0003633_abnormal_nervous_system0.64748780
173MP0001984_abnormal_olfaction0.64537036
174MP0004085_abnormal_heartbeat0.60752238

Predicted human phenotypes

RankGene SetZ-score
1Facial diplegia (HP:0001349)6.86367976
2Oligodactyly (hands) (HP:0001180)6.70877919
3Complement deficiency (HP:0004431)6.45940482
4Increased density of long bones (HP:0006392)5.48946960
5Aortic aneurysm (HP:0004942)5.41752563
6Congenital, generalized hypertrichosis (HP:0004540)5.26784349
7Gonadotropin excess (HP:0000837)5.26113568
8Absent hand (HP:0004050)4.80647426
9Cerebral inclusion bodies (HP:0100314)4.74793916
10Testicular atrophy (HP:0000029)4.64911584
11Abnormality of complement system (HP:0005339)4.49001307
12Recurrent gram-negative bacterial infections (HP:0005420)4.42269332
13Choroideremia (HP:0001139)4.36869201
14Oligodactyly (HP:0012165)4.31641712
15Lymphangioma (HP:0100764)4.20825659
16Central scotoma (HP:0000603)4.18107437
17Split foot (HP:0001839)4.12440865
18Aortic dissection (HP:0002647)4.01591158
19Ependymoma (HP:0002888)4.00478130
20Fair hair (HP:0002286)3.98745846
21Neurofibrillary tangles (HP:0002185)3.86741252
22Hypotrichosis (HP:0001006)3.72031184
23Potter facies (HP:0002009)3.67295426
24Facial shape deformation (HP:0011334)3.67295426
25Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.59776965
26Abnormality of macular pigmentation (HP:0008002)3.52592394
27Action tremor (HP:0002345)3.49730551
28Curly hair (HP:0002212)3.48918043
29Amniotic constriction ring (HP:0009775)3.46419071
30Abnormality of placental membranes (HP:0011409)3.46419071
31Abnormality of the astrocytes (HP:0100707)3.46165702
32Astrocytoma (HP:0009592)3.46165702
33Fibular aplasia (HP:0002990)3.45518953
34Hyperventilation (HP:0002883)3.44480782
35Menstrual irregularities (HP:0000858)3.35013130
36Short tibia (HP:0005736)3.28139747
37Hydroureter (HP:0000072)3.27084950
38Aplasia/Hypoplasia of the tibia (HP:0005772)3.24497163
39Abnormality of hair growth rate (HP:0011363)3.18773359
40Slow-growing hair (HP:0002217)3.18773359
41Focal motor seizures (HP:0011153)3.16574057
42Woolly hair (HP:0002224)3.03161372
43Sudden death (HP:0001699)3.01351208
44Overgrowth (HP:0001548)2.96703679
45Malnutrition (HP:0004395)2.93835920
46Intention tremor (HP:0002080)2.90095000
47Generalized hypopigmentation of hair (HP:0011358)2.87570051
48Dyschromatopsia (HP:0007641)2.87236321
49Premature ovarian failure (HP:0008209)2.86227433
50Progressive visual loss (HP:0000529)2.85559073
51Broad ribs (HP:0000885)2.82713374
52Abnormality of the fovea (HP:0000493)2.81415912
53Glioma (HP:0009733)2.73533378
54Tubulointerstitial fibrosis (HP:0005576)2.72976301
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.71994618
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.71994618
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.71852208
58Vacuolated lymphocytes (HP:0001922)2.66861477
59Dry hair (HP:0011359)2.66801653
60Cone-rod dystrophy (HP:0000548)2.65859221
61Visual hallucinations (HP:0002367)2.64031261
62Aplasia cutis congenita (HP:0001057)2.56123213
63Choanal stenosis (HP:0000452)2.56107110
64Vascular calcification (HP:0004934)2.54097299
65Tongue fasciculations (HP:0001308)2.53917937
66Increased hepatocellular lipid droplets (HP:0006565)2.51355575
67Spontaneous abortion (HP:0005268)2.49156884
68Cardiovascular calcification (HP:0011915)2.47906164
69Proximal tubulopathy (HP:0000114)2.47671778
70Stroke (HP:0001297)2.46237412
71Wide intermamillary distance (HP:0006610)2.43101789
72Absent speech (HP:0001344)2.42695137
73Hemiparesis (HP:0001269)2.42215046
74Muscle fibrillation (HP:0010546)2.36678924
75Neoplasm of the heart (HP:0100544)2.36202603
76Sparse scalp hair (HP:0002209)2.36130050
77Congenital ichthyosiform erythroderma (HP:0007431)2.35786378
78Hypophosphatemic rickets (HP:0004912)2.35116435
79Renal Fanconi syndrome (HP:0001994)2.34460373
80Hamartoma of the eye (HP:0010568)2.33000839
81Supranuclear gaze palsy (HP:0000605)2.31766676
82Blue irides (HP:0000635)2.31526729
83Buphthalmos (HP:0000557)2.29520804
84Stenosis of the external auditory canal (HP:0000402)2.29463968
85Abnormal rod and cone electroretinograms (HP:0008323)2.27791705
86Difficulty running (HP:0009046)2.25685362
87Hyperlipoproteinemia (HP:0010980)2.25509372
88Abnormal social behavior (HP:0012433)2.24066624
89Impaired social interactions (HP:0000735)2.24066624
903-Methylglutaconic aciduria (HP:0003535)2.23770846
91Volvulus (HP:0002580)2.22522357
92Thickened helices (HP:0000391)2.21906693
93Sensory axonal neuropathy (HP:0003390)2.21455274
94Testicular neoplasm (HP:0010788)2.20054866
95Supernumerary spleens (HP:0009799)2.18508842
96Pendular nystagmus (HP:0012043)2.18274158
97Scotoma (HP:0000575)2.17287216
98Cutis marmorata (HP:0000965)2.14937566
99Abnormality of the calcaneus (HP:0008364)2.14800112
100Focal seizures (HP:0007359)2.14244776
101Aneurysm (HP:0002617)2.12311598
102Absent eyebrow (HP:0002223)2.11757809
103Ankle clonus (HP:0011448)2.11706935
104Abnormality of the intervertebral disk (HP:0005108)2.11436613
105Bilateral sensorineural hearing impairment (HP:0008619)2.10740500
106Cubitus valgus (HP:0002967)2.10041211
107Abnormality of the corticospinal tract (HP:0002492)2.07812826
108Myocardial infarction (HP:0001658)2.07095663
109Keratoconus (HP:0000563)2.06512286
110Increased corneal curvature (HP:0100692)2.06512286
111Median cleft lip (HP:0000161)2.03852137
112Ketoacidosis (HP:0001993)2.03815971
113Status epilepticus (HP:0002133)2.03779933
114Absence seizures (HP:0002121)2.03082625
115Cupped ear (HP:0000378)2.02693639
116Hypopigmentation of the fundus (HP:0007894)2.01978701
117Growth hormone excess (HP:0000845)2.01283602
118Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00986505
119Bony spicule pigmentary retinopathy (HP:0007737)2.00005424
120Papilledema (HP:0001085)10.3157411
121Myokymia (HP:0002411)1.98952163
122Drooling (HP:0002307)1.97618524
123Excessive salivation (HP:0003781)1.97618524
124Abnormal hair whorl (HP:0010721)1.97206309
125Pigmentary retinal degeneration (HP:0001146)1.97030012
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96966313
127Exertional dyspnea (HP:0002875)1.96737043
128Hypoplastic nipples (HP:0002557)1.95492125
129Abnormality of chromosome segregation (HP:0002916)1.95419381
130Gonadal dysgenesis (HP:0000133)1.95253172
131Abnormal cortical bone morphology (HP:0003103)1.95174471
132Atonic seizures (HP:0010819)1.93324869
133Lymphedema (HP:0001004)1.93295680
134Amblyopia (HP:0000646)1.93097446
135Trigonocephaly (HP:0000243)1.91213786
136Glucose intolerance (HP:0000833)1.91205828
137Abnormality of calcium-phosphate metabolism (HP:0100530)1.91156436
138Infantile muscular hypotonia (HP:0008947)1.90630559
139Stridor (HP:0010307)1.90402583
140Pulmonary artery stenosis (HP:0004415)1.89966563
141Narrow forehead (HP:0000341)1.89207836
142Tubulointerstitial abnormality (HP:0001969)1.87958195
143Polar cataract (HP:0010696)1.87939587
144Clitoromegaly (HP:0000057)1.86806638
145Agitation (HP:0000713)1.85410931
146Constricted visual fields (HP:0001133)1.85359223
147Global brain atrophy (HP:0002283)1.84504870
148Absent toe (HP:0010760)1.83711339
149Abnormality of secondary sexual hair (HP:0009888)1.83235399
150Abnormality of the axillary hair (HP:0100134)1.83235399
151Hyperphosphatemia (HP:0002905)1.82922965
152Prolonged bleeding time (HP:0003010)1.81389318
15311 pairs of ribs (HP:0000878)1.80943298
154Macular degeneration (HP:0000608)1.80935097
155Arterial tortuosity (HP:0005116)1.80590086
156Lipid accumulation in hepatocytes (HP:0006561)1.80522587
157Dialeptic seizures (HP:0011146)1.78512342
158Restlessness (HP:0000711)1.78477557
159Aplasia involving bones of the upper limbs (HP:0009823)1.77725641
160Aplasia of the phalanges of the hand (HP:0009802)1.77725641
161Aplasia involving bones of the extremities (HP:0009825)1.77725641
162Decreased central vision (HP:0007663)1.77463752
163Syncope (HP:0001279)1.77172993
164Bicornuate uterus (HP:0000813)1.77087967
165Pancreatic fibrosis (HP:0100732)1.76695462
166Papillary thyroid carcinoma (HP:0002895)1.76183554
167Generalized tonic-clonic seizures (HP:0002069)1.75673146
168Abnormality of the pons (HP:0007361)1.75258592
169Aplasia/Hypoplasia of the fibula (HP:0006492)1.74135484
170Myopathic facies (HP:0002058)1.74027709
171True hermaphroditism (HP:0010459)1.73921166
172Absent eyelashes (HP:0000561)1.73802852
173Nonimmune hydrops fetalis (HP:0001790)1.73769605
174Enlarged penis (HP:0000040)1.73727643
175Duplicated collecting system (HP:0000081)1.72190052
176Skin nodule (HP:0200036)1.71079848
177Oligomenorrhea (HP:0000876)1.70661003
178Epileptic encephalopathy (HP:0200134)1.69576404
179Metaphyseal cupping (HP:0003021)1.67722137
180Psychosis (HP:0000709)1.65966229
181Nuclear cataract (HP:0100018)1.65946171
182Clumsiness (HP:0002312)1.65598673
183Hand muscle atrophy (HP:0009130)1.64837451
184Amyloidosis (HP:0011034)1.62778879
185Type 1 muscle fiber predominance (HP:0003803)1.61573195
186Hypoventilation (HP:0002791)1.61229534
187Aortic regurgitation (HP:0001659)1.59606104
188Muscle fiber splitting (HP:0003555)1.57834745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B7.72626301
2MYLK6.36538473
3RIPK44.97160268
4EPHA44.96168212
5CDK84.51210590
6TIE14.43761209
7TGFBR13.70313641
8AKT32.93518567
9NTRK32.84585766
10MAPK132.62681281
11DMPK2.54090828
12CDK92.48746190
13FRK2.43200260
14TTN2.30384766
15GRK12.28057266
16MAP3K42.16419600
17GRK61.97160108
18PTK2B1.95826421
19STK38L1.93455969
20NEK61.92550158
21STK241.85968503
22CCNB11.84108937
23MAP2K41.75621725
24BMPR21.74189884
25MST41.68876730
26PAK21.67482179
27PIK3CG1.67373048
28FER1.63620525
29INSRR1.61490051
30MAP2K71.57110273
31TAOK31.54826467
32MAP3K121.53729908
33GRK51.48559265
34LMTK21.47868989
35MINK11.45293001
36FGR1.42968518
37PNCK1.39498837
38DAPK11.14553205
39PLK21.14170914
40CAMK1G1.14030067
41PIM11.10841583
42NTRK11.10559126
43MAP4K21.10508561
44NTRK21.09851750
45WNK41.07800999
46PKN11.06780205
47RAF11.05870990
48NME11.05820602
49FGFR21.04481127
50DDR20.97156687
51MAP3K90.93377942
52CAMK2B0.92041370
53PAK30.91905077
54MAP3K20.91493899
55CAMK1D0.90178599
56ADRBK20.89497483
57DAPK20.88798072
58STK30.87443762
59DAPK30.87353044
60NUAK10.87293932
61CDK70.81733291
62KSR20.80732644
63CAMK2G0.80138923
64CDK50.78678880
65CAMK2A0.77662995
66MAPKAPK30.77509375
67FYN0.75585982
68MKNK20.75269582
69MAP3K130.74517141
70MAP3K60.73481238
71TRIM280.71128425
72TNK20.70105163
73YES10.70059566
74PRKCG0.69916030
75KSR10.69876344
76ROCK20.69683837
77PRKD30.68351118
78VRK20.68202851
79MST1R0.67634929
80CSNK1G20.66674553
81GRK70.66081466
82PDGFRA0.65573758
83PINK10.64684367
84ADRBK10.63271947
85CDC42BPA0.60970202
86SIK10.59552878
87RIPK10.58810034
88PRKCQ0.58291344
89FES0.57389816
90CASK0.57163209
91CHUK0.55885452
92PKN20.54537625
93STK390.54159764
94ILK0.53641976
95RET0.53184800
96SGK10.53114358
97STK380.52927657
98OXSR10.52217172
99VRK10.51841942
100MAPK70.51177805
101CAMK2D0.50386890
102BRSK20.50176082
103EGFR0.49632638
104SYK0.49552480
105PRKD20.47597133
106PDK30.47178708
107PDK40.47178708
108TYRO30.46547618
109LATS20.46461560
110PDPK10.46273699
111JAK30.46021879
112MAP2K10.45470756
113TRIB30.45417974
114ARAF0.45167757
115PTK20.44978491
116LATS10.43617712
117IKBKB0.43137252
118ROCK10.42531347
119TEC0.42368099
120INSR0.42129115
121PRKG20.40973819
122EIF2AK20.39482325
123ZAK0.38933257
124CAMK10.38901678
125MAP3K70.38643442
126PRKD10.38642140
127MATK0.37909029
128TESK10.37126466
129SRC0.37110645
130STK160.36540815
131TNIK0.36303007
132BCR0.35575858
133PDK20.34845807
134LRRK20.34824077
135ABL20.34080221
136PRKCZ0.33551296
137PAK60.33396819
138PAK10.33033586
139PHKG20.32651372
140PHKG10.32651372
141CDK190.32535919
142WEE10.32485396
143PIK3CA0.31677851
144PRKCE0.30495420
145SIK30.30058415
146TAF10.28961371
147ITK0.28444890
148CSF1R0.27207532
149PRKG10.26060138
150MAPK150.25780626
151MET0.24684720
152TSSK60.24423435
153PRKACB0.23792035
154EPHA30.22984092
155FGFR10.22118716
156IGF1R0.22058917
157PRKCA0.20964270
158PDK10.19961659
159PRKCI0.19158887
160MARK10.15636486
161PRKACA0.15290141

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.69881959
2Protein export_Homo sapiens_hsa030603.22475548
3Caffeine metabolism_Homo sapiens_hsa002322.97603961
4ABC transporters_Homo sapiens_hsa020102.72521380
5Salivary secretion_Homo sapiens_hsa049702.58960062
6Long-term potentiation_Homo sapiens_hsa047202.52192017
7Vitamin digestion and absorption_Homo sapiens_hsa049772.50919412
8Nicotine addiction_Homo sapiens_hsa050332.49930981
9Basal transcription factors_Homo sapiens_hsa030222.43250585
10Renin secretion_Homo sapiens_hsa049242.16702190
11Nitrogen metabolism_Homo sapiens_hsa009102.05037024
12Gastric acid secretion_Homo sapiens_hsa049712.01983649
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96499755
14Sulfur metabolism_Homo sapiens_hsa009201.95083878
15Amphetamine addiction_Homo sapiens_hsa050311.90477997
16Renin-angiotensin system_Homo sapiens_hsa046141.80218743
17Circadian entrainment_Homo sapiens_hsa047131.79708919
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78829873
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.76862617
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74478409
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67824956
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65751248
23Endometrial cancer_Homo sapiens_hsa052131.64127100
24Prion diseases_Homo sapiens_hsa050201.62595754
25Glutamatergic synapse_Homo sapiens_hsa047241.61081743
26Calcium signaling pathway_Homo sapiens_hsa040201.59828993
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59483690
28Thyroid hormone synthesis_Homo sapiens_hsa049181.58905231
29Collecting duct acid secretion_Homo sapiens_hsa049661.57360655
30PPAR signaling pathway_Homo sapiens_hsa033201.49122310
31Regulation of autophagy_Homo sapiens_hsa041401.48733381
32Taste transduction_Homo sapiens_hsa047421.48162292
33Glycerolipid metabolism_Homo sapiens_hsa005611.42986779
34Oxytocin signaling pathway_Homo sapiens_hsa049211.41607280
35Renal cell carcinoma_Homo sapiens_hsa052111.39772562
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39648729
37GABAergic synapse_Homo sapiens_hsa047271.39312440
38Hedgehog signaling pathway_Homo sapiens_hsa043401.39221073
39African trypanosomiasis_Homo sapiens_hsa051431.36196774
40TGF-beta signaling pathway_Homo sapiens_hsa043501.35701766
41Dopaminergic synapse_Homo sapiens_hsa047281.34199830
42Morphine addiction_Homo sapiens_hsa050321.33207290
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32895333
44Alzheimers disease_Homo sapiens_hsa050101.32071493
45Fatty acid metabolism_Homo sapiens_hsa012121.26921569
46Fatty acid biosynthesis_Homo sapiens_hsa000611.26549362
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26318905
48Fatty acid degradation_Homo sapiens_hsa000711.25875342
49Vitamin B6 metabolism_Homo sapiens_hsa007501.24038751
50Histidine metabolism_Homo sapiens_hsa003401.23702549
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.21177273
52Tight junction_Homo sapiens_hsa045301.21042984
53Serotonergic synapse_Homo sapiens_hsa047261.18615688
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16420891
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14949956
56Complement and coagulation cascades_Homo sapiens_hsa046101.14795962
57Oxidative phosphorylation_Homo sapiens_hsa001901.10981615
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07776582
59Long-term depression_Homo sapiens_hsa047301.05489849
60cAMP signaling pathway_Homo sapiens_hsa040241.04978102
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99235105
62RNA degradation_Homo sapiens_hsa030180.98552947
63GnRH signaling pathway_Homo sapiens_hsa049120.97839451
64mTOR signaling pathway_Homo sapiens_hsa041500.97371541
65Vibrio cholerae infection_Homo sapiens_hsa051100.95749555
66Arachidonic acid metabolism_Homo sapiens_hsa005900.95508288
67Cardiac muscle contraction_Homo sapiens_hsa042600.95060751
68Non-small cell lung cancer_Homo sapiens_hsa052230.94193298
69Propanoate metabolism_Homo sapiens_hsa006400.93983727
70Synaptic vesicle cycle_Homo sapiens_hsa047210.93187533
71Circadian rhythm_Homo sapiens_hsa047100.92297903
72B cell receptor signaling pathway_Homo sapiens_hsa046620.92260945
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91880775
74Pancreatic secretion_Homo sapiens_hsa049720.91395734
75Insulin secretion_Homo sapiens_hsa049110.91213309
76Olfactory transduction_Homo sapiens_hsa047400.91149842
77Bile secretion_Homo sapiens_hsa049760.89438679
78Acute myeloid leukemia_Homo sapiens_hsa052210.89064568
79Estrogen signaling pathway_Homo sapiens_hsa049150.87907811
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87463588
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86837842
82Arginine biosynthesis_Homo sapiens_hsa002200.85560801
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84590878
84Oocyte meiosis_Homo sapiens_hsa041140.83954008
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81551214
86HIF-1 signaling pathway_Homo sapiens_hsa040660.80288724
87Cholinergic synapse_Homo sapiens_hsa047250.79809412
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.77968745
89Mineral absorption_Homo sapiens_hsa049780.76788882
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76480615
91Axon guidance_Homo sapiens_hsa043600.75700090
92Glucagon signaling pathway_Homo sapiens_hsa049220.75414397
93Melanogenesis_Homo sapiens_hsa049160.74440938
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74428425
95Ras signaling pathway_Homo sapiens_hsa040140.74044531
96FoxO signaling pathway_Homo sapiens_hsa040680.73336617
97Prolactin signaling pathway_Homo sapiens_hsa049170.72878804
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72612211
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72447005
100Pyruvate metabolism_Homo sapiens_hsa006200.71837707
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70974436
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70930631
103Protein digestion and absorption_Homo sapiens_hsa049740.70376604
104Gap junction_Homo sapiens_hsa045400.68970853
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68900405
106Prostate cancer_Homo sapiens_hsa052150.68193637
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66594293
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66499595
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.65663102
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65389437
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.65382793
112Tyrosine metabolism_Homo sapiens_hsa003500.63632931
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62555029
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60544306
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60184246
116ECM-receptor interaction_Homo sapiens_hsa045120.59357165
117Glioma_Homo sapiens_hsa052140.59303806
118VEGF signaling pathway_Homo sapiens_hsa043700.59010213
119Tryptophan metabolism_Homo sapiens_hsa003800.56829548
120Melanoma_Homo sapiens_hsa052180.56547616
121Focal adhesion_Homo sapiens_hsa045100.55090623
122Type II diabetes mellitus_Homo sapiens_hsa049300.52876738
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52697382
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52348869
125Ovarian steroidogenesis_Homo sapiens_hsa049130.51939015
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51446276
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.50260266
128Ribosome_Homo sapiens_hsa030100.49418817
129Chemical carcinogenesis_Homo sapiens_hsa052040.49228564
130Carbon metabolism_Homo sapiens_hsa012000.49051689
131Choline metabolism in cancer_Homo sapiens_hsa052310.48782432
132Huntingtons disease_Homo sapiens_hsa050160.48735251
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48440017
134Platelet activation_Homo sapiens_hsa046110.47263509
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47117489
136Hepatitis C_Homo sapiens_hsa051600.46813902
137Fat digestion and absorption_Homo sapiens_hsa049750.46218932
138Phototransduction_Homo sapiens_hsa047440.46033650
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46001682
140Rap1 signaling pathway_Homo sapiens_hsa040150.45601239
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45407905
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45247865
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45007382
144Parkinsons disease_Homo sapiens_hsa050120.44768735
145Peroxisome_Homo sapiens_hsa041460.44197631
146Staphylococcus aureus infection_Homo sapiens_hsa051500.44046150
147Cocaine addiction_Homo sapiens_hsa050300.43925111
148Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42742252
149Dilated cardiomyopathy_Homo sapiens_hsa054140.41531810
150Hippo signaling pathway_Homo sapiens_hsa043900.41506053
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40317576
152Chemokine signaling pathway_Homo sapiens_hsa040620.39058678
153Phenylalanine metabolism_Homo sapiens_hsa003600.39024987
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.38305998
155Glutathione metabolism_Homo sapiens_hsa004800.38132841
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37410655
157Adherens junction_Homo sapiens_hsa045200.37152291

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