SPINK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epidermis development (GO:0008544)8.76031827
2establishment of skin barrier (GO:0061436)8.08067273
3complement activation, classical pathway (GO:0006958)7.61824553
4desmosome organization (GO:0002934)7.31183532
5hair cell differentiation (GO:0035315)7.27752880
6regulation of water loss via skin (GO:0033561)6.88470624
7apical protein localization (GO:0045176)6.65585475
8complement activation (GO:0006956)5.88942778
9positive regulation of monocyte chemotaxis (GO:0090026)5.69832053
10sequestering of metal ion (GO:0051238)5.33945277
11membrane raft organization (GO:0031579)5.30370375
12keratinocyte proliferation (GO:0043616)5.20122799
13multicellular organismal water homeostasis (GO:0050891)5.19718645
14molting cycle (GO:0042303)5.11107374
15hair cycle (GO:0042633)5.11107374
16response to phenylpropanoid (GO:0080184)4.95951826
17negative regulation of interleukin-17 production (GO:0032700)4.88453879
18regulation of T cell migration (GO:2000404)4.84528547
19positive regulation of granulocyte chemotaxis (GO:0071624)4.84362759
20long-chain fatty acid biosynthetic process (GO:0042759)4.79865789
21localization within membrane (GO:0051668)4.72348093
22lipoxygenase pathway (GO:0019372)4.71904152
23transepithelial transport (GO:0070633)4.67429788
24asymmetric protein localization (GO:0008105)4.49825971
25water homeostasis (GO:0030104)4.42948945
26bundle of His cell to Purkinje myocyte communication (GO:0086069)4.42500994
27regulation of monocyte chemotaxis (GO:0090025)4.33607440
28epithelial cell differentiation (GO:0030855)4.29149667
29negative regulation of bone mineralization (GO:0030502)4.28637457
30positive regulation of T cell chemotaxis (GO:0010820)4.24683002
31regulation of T cell chemotaxis (GO:0010819)4.24683002
32protein activation cascade (GO:0072376)4.20818716
33epithelium development (GO:0060429)4.07971661
34negative regulation of biomineral tissue development (GO:0070168)3.93164690
35positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.89576010
36negative regulation of homotypic cell-cell adhesion (GO:0034111)3.84411441
37intermediate filament cytoskeleton organization (GO:0045104)3.77619412
38ectoderm development (GO:0007398)3.76998992
39positive regulation of antigen processing and presentation (GO:0002579)3.68761519
40negative regulation of interferon-gamma production (GO:0032689)3.64933075
41intermediate filament-based process (GO:0045103)3.64547170
42angiotensin maturation (GO:0002003)3.63302833
43Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.62600210
44immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.62600210
45Fc-gamma receptor signaling pathway (GO:0038094)3.62600210
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60843091
47Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.58776222
48hair follicle morphogenesis (GO:0031069)3.52000486
49antimicrobial humoral response (GO:0019730)3.50961976
50linoleic acid metabolic process (GO:0043651)3.46642006
51regulation of lymphocyte migration (GO:2000401)3.44763232
52negative regulation of cell-cell adhesion (GO:0022408)3.37624421
53positive regulation of T cell migration (GO:2000406)3.36607612
54keratinocyte development (GO:0003334)3.33502766
55hemidesmosome assembly (GO:0031581)3.27036610
56regulation of granulocyte chemotaxis (GO:0071622)3.25313083
57positive regulation of Cdc42 GTPase activity (GO:0043089)3.20782814
58chronic inflammatory response (GO:0002544)3.16892947
59negative regulation of cytokine-mediated signaling pathway (GO:0001960)3.16457055
60humoral immune response (GO:0006959)3.11077060
61cytokine biosynthetic process (GO:0042089)3.09045730
62regulation of ruffle assembly (GO:1900027)3.08209105
63keratinization (GO:0031424)27.3547058
64defense response to fungus (GO:0050832)2.94637517
65negative regulation of response to cytokine stimulus (GO:0060761)2.93741502
66intermediate filament organization (GO:0045109)2.93676263
67O-glycan processing (GO:0016266)2.87538397
68superoxide anion generation (GO:0042554)2.87497488
69regulation of interleukin-17 production (GO:0032660)2.80279632
70regulation of neuron projection regeneration (GO:0070570)2.78881205
71regulation of axon regeneration (GO:0048679)2.78881205
72positive regulation of endothelial cell differentiation (GO:0045603)2.77275965
73defense response to Gram-negative bacterium (GO:0050829)2.73202763
74positive regulation of lymphocyte migration (GO:2000403)2.72717342
75regulation of lymphocyte chemotaxis (GO:1901623)2.68908281
76regulation of antigen processing and presentation (GO:0002577)2.66926488
77detection of bacterium (GO:0016045)2.53841864
78regulation of platelet aggregation (GO:0090330)2.53451142
79leukocyte aggregation (GO:0070486)2.52745454
80regulation of mitochondrial depolarization (GO:0051900)2.51922969
81intestinal epithelial cell development (GO:0060576)2.48987024
82cytokine metabolic process (GO:0042107)2.48157491
83positive regulation of epidermis development (GO:0045684)2.47462553
84negative regulation of keratinocyte proliferation (GO:0010839)2.45749764
85heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.42228976
86response to UV-B (GO:0010224)2.38733812
87skeletal muscle contraction (GO:0003009)2.37263786
88gap junction assembly (GO:0016264)2.32119919
89eyelid development in camera-type eye (GO:0061029)2.30526172
90positive regulation of epidermal cell differentiation (GO:0045606)2.29932906
91negative regulation of platelet activation (GO:0010544)2.29250180
92detection of other organism (GO:0098543)2.28551580
93leukocyte migration involved in inflammatory response (GO:0002523)2.27194576
94wound healing (GO:0042060)2.19378211
95negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.16640888
96positive regulation of neutrophil chemotaxis (GO:0090023)2.15480714
97positive regulation of neutrophil migration (GO:1902624)2.15480714
98peptide cross-linking (GO:0018149)19.5685648
99keratinocyte differentiation (GO:0030216)17.6847130
100epidermal cell differentiation (GO:0009913)14.2391727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.31273439
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.07363964
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.50042239
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.71338318
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.21584762
6* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.20842866
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.54783271
8VDR_22108803_ChIP-Seq_LS180_Human2.50530827
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.46024117
10ERG_20517297_ChIP-Seq_VCAP_Human2.10910024
11TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07174725
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06627786
13GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.03127576
14SOX2_20726797_ChIP-Seq_SW620_Human1.98609817
15KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.93752977
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.91181120
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.91181120
18SOX9_24532713_ChIP-Seq_HFSC_Mouse1.84709679
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74208321
20ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.72746670
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71857854
22CTCF_27219007_Chip-Seq_Bcells_Human1.70580405
23GATA6_21074721_ChIP-Seq_CACO-2_Human1.62483860
24DNAJC2_21179169_ChIP-ChIP_NT2_Human1.61037186
25SMC4_20622854_ChIP-Seq_HELA_Human1.56816335
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55036408
27TP63_22573176_ChIP-Seq_HFKS_Human1.54677351
28ATF3_27146783_Chip-Seq_COLON_Human1.54493291
29EGR1_19032775_ChIP-ChIP_M12_Human1.54423953
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.50924872
31CTCF_20526341_ChIP-Seq_ESCs_Human1.50536977
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50371781
33* ESR1_20079471_ChIP-ChIP_T-47D_Human1.42664601
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41811554
35RXR_22108803_ChIP-Seq_LS180_Human1.40455259
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35176659
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33674526
38GATA3_24758297_ChIP-Seq_MCF-7_Human1.33408257
39E2F1_20622854_ChIP-Seq_HELA_Human1.30165259
40RACK7_27058665_Chip-Seq_MCF-7_Human1.28770486
41KLF5_25053715_ChIP-Seq_YYC3_Human1.25524736
42NANOG_20526341_ChIP-Seq_ESCs_Human1.25196405
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24833888
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.24666963
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.23293608
46FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21837072
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18143763
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.17958856
49CJUN_26792858_Chip-Seq_BT549_Human1.17725607
50BCL6_27268052_Chip-Seq_Bcells_Human1.13744897
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13416675
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13013872
53P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11350856
54LXR_22292898_ChIP-Seq_THP-1_Human1.10478016
55STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10302763
56GATA4_25053715_ChIP-Seq_YYC3_Human1.09725665
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09098537
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08715358
59TP63_23658742_ChIP-Seq_EP156T_Human1.08403608
60CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07250713
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06339943
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.04459046
63SA1_27219007_Chip-Seq_Bcells_Human1.04102197
64RBPJ_21746931_ChIP-Seq_IB4_Human1.02834212
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01065223
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00067032
67BCOR_27268052_Chip-Seq_Bcells_Human0.99805514
68GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98359061
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98283374
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97980295
71MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.96802865
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95812653
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95767334
74RAC3_21632823_ChIP-Seq_H3396_Human0.94014456
75CREB1_26743006_Chip-Seq_LNCaP_Human0.93599904
76FOXO3_23340844_ChIP-Seq_DLD1_Human0.92563557
77KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92514603
78TRIM28_21343339_ChIP-Seq_HEK293_Human0.92368744
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92235891
80AR_25329375_ChIP-Seq_VCAP_Human0.92097551
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.91863447
82AHR_22903824_ChIP-Seq_MCF-7_Human0.90361056
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90001431
84CEBPB_22108803_ChIP-Seq_LS180_Human0.89519852
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87105333
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86782752
87TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86588151
88CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85746405
89STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85173031
90YY1_22570637_ChIP-Seq_MALME-3M_Human0.84821560
91GATA6_25053715_ChIP-Seq_YYC3_Human0.84562728
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83513780
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83483654
94HTT_18923047_ChIP-ChIP_STHdh_Human0.83285138
95KDM2B_26808549_Chip-Seq_DND41_Human0.82351058
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81614630
97ERA_21632823_ChIP-Seq_H3396_Human0.79590963
98SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79572821
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.79509036
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.79509036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.16500703
2MP0005275_abnormal_skin_tensile5.57673943
3MP0004043_abnormal_pH_regulation4.19262741
4MP0010678_abnormal_skin_adnexa4.06713778
5MP0005501_abnormal_skin_physiology3.50532293
6MP0005409_darkened_coat_color3.15326826
7MP0000467_abnormal_esophagus_morphology2.86928954
8MP0000579_abnormal_nail_morphology2.63357145
9MP0002098_abnormal_vibrissa_morphology2.16492437
10MP0010234_abnormal_vibrissa_follicle14.2878126
11MP0001216_abnormal_epidermal_layer1.95338687
12MP0003453_abnormal_keratinocyte_physiol1.94561460
13MP0000762_abnormal_tongue_morphology1.86229155
14MP0004381_abnormal_hair_follicle1.77240515
15MP0010352_gastrointestinal_tract_polyps1.73235322
16MP0000465_gastrointestinal_hemorrhage1.66670394
17MP0000383_abnormal_hair_follicle1.65375989
18MP0010771_integument_phenotype1.65344836
19MP0000377_abnormal_hair_follicle1.63765216
20MP0005503_abnormal_tendon_morphology1.54041748
21MP0004885_abnormal_endolymph1.53336757
22MP0003724_increased_susceptibility_to1.46856415
23MP0001851_eye_inflammation1.45784097
24MP0005377_hearing/vestibular/ear_phenot1.38888387
25MP0003878_abnormal_ear_physiology1.38888387
26MP0002095_abnormal_skin_pigmentation1.14820038
27MP0000678_abnormal_parathyroid_gland1.13339039
28MP0004264_abnormal_extraembryonic_tissu1.08104300
29MP0004185_abnormal_adipocyte_glucose1.03614998
30MP0003315_abnormal_perineum_morphology1.02466922
31MP0001879_abnormal_lymphatic_vessel0.95622537
32MP0003705_abnormal_hypodermis_morpholog0.90867085
33MP0003646_muscle_fatigue0.90116273
34MP0009931_abnormal_skin_appearance0.86949787
35MP0009053_abnormal_anal_canal0.84589980
36MP0002060_abnormal_skin_morphology0.83878459
37MP0004947_skin_inflammation0.83221100
38MP0010368_abnormal_lymphatic_system0.81894137
39MP0001243_abnormal_dermal_layer0.77762468
40MP0000367_abnormal_coat/_hair0.77519069
41MP0000427_abnormal_hair_cycle0.74906643
42MP0002249_abnormal_larynx_morphology0.73088960
43MP0003566_abnormal_cell_adhesion0.71327640
44MP0009780_abnormal_chondrocyte_physiolo0.70158020
45MP0002234_abnormal_pharynx_morphology0.66384979
46MP0000470_abnormal_stomach_morphology0.65818390
47MP0010030_abnormal_orbit_morphology0.65271820
48MP0002108_abnormal_muscle_morphology0.59578153
49MP0005666_abnormal_adipose_tissue0.59391093
50MP0000049_abnormal_middle_ear0.58537754
51MP0001784_abnormal_fluid_regulation0.58494744
52MP0003828_pulmonary_edema0.55420226
53MP0005023_abnormal_wound_healing0.55082441
54MP0000371_diluted_coat_color0.53650535
55MP0003806_abnormal_nucleotide_metabolis0.52766506
56MP0001270_distended_abdomen0.52143931
57MP0001765_abnormal_ion_homeostasis0.51448328
58MP0000566_synostosis0.45501632
59MP0005670_abnormal_white_adipose0.45073600
60MP0005375_adipose_tissue_phenotype0.41755617
61MP0000751_myopathy0.41205700
62MP0006138_congestive_heart_failure0.40140425
63MP0009333_abnormal_splenocyte_physiolog0.38748474
64MP0003638_abnormal_response/metabolism_0.38163246
65MP0004145_abnormal_muscle_electrophysio0.37320245
66MP0002075_abnormal_coat/hair_pigmentati0.36990949
67MP0002933_joint_inflammation0.35454566
68MP0001873_stomach_inflammation0.35127624
69MP0000613_abnormal_salivary_gland0.33485254
70MP0003633_abnormal_nervous_system0.33426512
71MP0005166_decreased_susceptibility_to0.32793347
72MP0002138_abnormal_hepatobiliary_system0.32246284
73MP0001191_abnormal_skin_condition0.31959684
74MP0001485_abnormal_pinna_reflex0.31809669
75MP0000759_abnormal_skeletal_muscle0.31218819
76MP0000685_abnormal_immune_system0.30630037
77MP0001502_abnormal_circadian_rhythm0.30185543
78MP0002148_abnormal_hypersensitivity_rea0.28725558
79MP0002332_abnormal_exercise_endurance0.28660356
80MP0000920_abnormal_myelination0.28601066
81MP0000681_abnormal_thyroid_gland0.26290118
82MP0003755_abnormal_palate_morphology0.26160301
83MP0002166_altered_tumor_susceptibility0.25788991
84MP0005167_abnormal_blood-brain_barrier0.25426736
85MP0004087_abnormal_muscle_fiber0.24720264
86MP0002254_reproductive_system_inflammat0.24682942
87MP0009115_abnormal_fat_cell0.23788950
88MP0000749_muscle_degeneration0.23100301
89MP0001340_abnormal_eyelid_morphology0.22435220
90MP0008569_lethality_at_weaning0.22200333
91MP0005369_muscle_phenotype0.22179766
92MP0001958_emphysema0.21780796
93MP0004036_abnormal_muscle_relaxation0.21715569
94MP0009643_abnormal_urine_homeostasis0.21687555
95MP0005025_abnormal_response_to0.21513878
96MP0005385_cardiovascular_system_phenoty0.21206486
97MP0001544_abnormal_cardiovascular_syste0.21206486
98MP0008004_abnormal_stomach_pH0.20658899
99MP0005330_cardiomyopathy0.19724014
100MP0005193_abnormal_anterior_eye0.19654285

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)8.71023117
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.69838742
3Palmar hyperkeratosis (HP:0010765)8.25430092
4Abnormality of nail color (HP:0100643)8.22888366
5Erythroderma (HP:0001019)7.99596412
6Fragile nails (HP:0001808)7.98509543
7Congenital ichthyosiform erythroderma (HP:0007431)7.58404925
8Plantar hyperkeratosis (HP:0007556)7.01683583
9Pustule (HP:0200039)6.40111929
10Erythema (HP:0010783)6.27199988
11Villous atrophy (HP:0011473)5.88026046
12Abnormality of small intestinal villus morphology (HP:0011472)5.88026046
13Alopecia of scalp (HP:0002293)5.16719208
14Sparse scalp hair (HP:0002209)4.91069741
15Brittle hair (HP:0002299)4.54250002
16Thick nail (HP:0001805)4.39022974
17Parakeratosis (HP:0001036)4.35660491
18Acanthosis nigricans (HP:0000956)3.79569362
19Right ventricular cardiomyopathy (HP:0011663)3.74021635
20Lip pit (HP:0100267)3.70636094
21Hypotrichosis (HP:0001006)3.56202608
22Nail dystrophy (HP:0008404)3.54123718
23Corneal erosion (HP:0200020)3.48602187
24Urticaria (HP:0001025)3.36736159
25Palmoplantar keratoderma (HP:0000982)3.32218180
26Onycholysis (HP:0001806)3.31155226
27Dehydration (HP:0001944)3.01951627
28Distal lower limb muscle weakness (HP:0009053)2.99200085
29Abnormality of the axillary hair (HP:0100134)2.96680356
30Abnormality of secondary sexual hair (HP:0009888)2.96680356
31Nasal polyposis (HP:0100582)2.92102297
32Abnormality of the nasal mucosa (HP:0000433)2.85266039
33Absent eyelashes (HP:0000561)2.82044128
34Hyperactive renin-angiotensin system (HP:0000841)2.80320821
35Hypergammaglobulinemia (HP:0010702)2.80263524
36Ectropion (HP:0000656)2.77861255
37Hypohidrosis (HP:0000966)2.68274622
38Hyporeflexia of lower limbs (HP:0002600)2.61228780
39Furrowed tongue (HP:0000221)2.59670321
40Absent hair (HP:0002298)2.54365242
41Emphysema (HP:0002097)2.54054530
42Eczematoid dermatitis (HP:0000976)2.48385942
43Woolly hair (HP:0002224)2.46575661
44Hyperkalemia (HP:0002153)2.45728032
45Ridged nail (HP:0001807)2.28925703
46Abnormality of the salivary glands (HP:0010286)2.21910427
47Abnormal blistering of the skin (HP:0008066)2.17075604
48Amniotic constriction ring (HP:0009775)2.16864691
49Abnormality of placental membranes (HP:0011409)2.16864691
50Gangrene (HP:0100758)2.14624921
51Milia (HP:0001056)2.13865783
52Hyperhidrosis (HP:0000975)2.11568650
53Fine hair (HP:0002213)2.07521432
54Malnutrition (HP:0004395)2.03057327
55Increased IgE level (HP:0003212)10.5301472
56Oral leukoplakia (HP:0002745)10.4594452
57Abnormality of the neuromuscular junction (HP:0003398)1.91902105
58Fatigable weakness (HP:0003473)1.91902105
59Exercise-induced myalgia (HP:0003738)1.88430562
60Decreased circulating renin level (HP:0003351)1.86872872
61Verrucae (HP:0200043)1.84676120
62Papilloma (HP:0012740)1.84676120
63Oligodontia (HP:0000677)1.76683135
64Chronic bronchitis (HP:0004469)1.76586261
65Sparse eyelashes (HP:0000653)1.75435121
66Nonprogressive disorder (HP:0003680)1.75236042
67Nemaline bodies (HP:0003798)1.74499742
68Absence seizures (HP:0002121)1.73792073
69Laryngomalacia (HP:0001601)1.73711863
70Autoamputation (HP:0001218)1.71083142
71Ulnar claw (HP:0001178)1.71043920
72Popliteal pterygium (HP:0009756)1.67517085
73Cystic hygroma (HP:0000476)1.67279072
74Skin rash (HP:0000988)1.67258285
75Corneal dystrophy (HP:0001131)1.67109308
76Elbow flexion contracture (HP:0002987)1.65729871
77Follicular hyperkeratosis (HP:0007502)1.65455049
78Asthma (HP:0002099)1.62013967
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.61764568
80Multifactorial inheritance (HP:0001426)1.61164305
81Delusions (HP:0000746)1.60953920
82Muscle fiber inclusion bodies (HP:0100299)1.58235879
83Skin ulcer (HP:0200042)1.56352979
84Hypokalemic alkalosis (HP:0001949)1.53542963
85Pruritus (HP:0000989)1.50713576
86Type 1 muscle fiber predominance (HP:0003803)1.50390102
87Dry skin (HP:0000958)1.49097241
88Difficulty running (HP:0009046)1.48128036
89Areflexia of lower limbs (HP:0002522)1.42903176
90Blepharitis (HP:0000498)1.40782138
91Hoarse voice (HP:0001609)1.38503594
92Systemic lupus erythematosus (HP:0002725)1.33155044
93Renal salt wasting (HP:0000127)1.31663620
94Distal arthrogryposis (HP:0005684)1.31354115
95Abnormality of renin-angiotensin system (HP:0000847)1.28676011
96Abnormality of chloride homeostasis (HP:0011422)1.27646696
97Hyperaldosteronism (HP:0000859)1.26549011
98Lack of skin elasticity (HP:0100679)1.26018280
99Recurrent corneal erosions (HP:0000495)1.24113830
100Seborrheic dermatitis (HP:0001051)1.23115480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK34.72106358
2MAP3K93.45348862
3TTN2.97781979
4MAP3K32.84335086
5MAP3K22.69885906
6RIPK12.46719886
7OBSCN2.38694725
8EPHB22.30010207
9NME12.24487676
10TRPM72.22107855
11STK242.07629518
12TAOK12.07529346
13ERN12.04183470
14EPHA21.96921200
15MAP3K61.95433991
16SGK2231.89850172
17SGK4941.89850172
18LRRK21.88399129
19MARK21.87604509
20PINK11.75879858
21GRK61.68936819
22RPS6KB21.68761037
23TGFBR11.67135520
24SGK21.65953680
25LATS11.56313011
26MAP3K11.53825609
27WNK11.49403964
28FER1.43317319
29NLK1.42730539
30SGK31.42131758
31DMPK1.41807142
32ERBB31.36287041
33TYRO31.32020550
34PIK3CG1.30468710
35BLK1.25970045
36TGFBR21.21182059
37CAMK1D1.11395586
38MYLK1.10856152
39ZAP701.02185428
40PRKD20.99520147
41MST40.94096657
42TBK10.92425423
43NEK20.89960380
44IKBKE0.89288131
45TIE10.83099256
46MARK30.81400399
47CSK0.80823525
48GRK50.80318972
49STK390.78303379
50PHKG20.77572181
51PHKG10.77572181
52WNK40.76793297
53CSNK1A1L0.75288647
54PDGFRB0.75024083
55FGFR30.72305808
56MAPKAPK20.71024800
57EPHA30.70147000
58ADRBK10.67158965
59HIPK20.66001016
60FGR0.63235908
61ICK0.60519184
62MAP3K70.58540909
63MTOR0.57532109
64CAMK1G0.56954688
65ARAF0.56505135
66FGFR10.55466769
67SGK10.54298072
68PRKD10.53699036
69MAP3K110.51964801
70ILK0.51878196
71PTK20.50967425
72BCR0.50570750
73AKT20.49977479
74MAP2K60.49765097
75MST1R0.49306380
76MET0.48723682
77CDC42BPA0.48691295
78CSNK1G30.48259277
79NME20.47763862
80MAPK70.47591155
81PRKAA20.47008149
82ABL20.46873349
83TAOK30.46801420
84HCK0.45510903
85PRKCQ0.44673241
86CSNK1G10.43908439
87PKN10.43732460
88RPS6KB10.41757229
89IRAK10.41060054
90TRIB30.40587753
91BMPR1B0.40406177
92GRK10.37809833
93EPHB10.36577984
94STK30.35694337
95PIM20.34340797
96PTK60.34125650
97MAP3K120.32279029
98JAK30.30870005
99PRKCI0.30367180
100PRKG10.30191623

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046143.28341825
2Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.91577663
3Arachidonic acid metabolism_Homo sapiens_hsa005902.84559462
4Salivary secretion_Homo sapiens_hsa049702.78734059
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.36224169
6Phototransduction_Homo sapiens_hsa047442.12760062
7Pertussis_Homo sapiens_hsa051332.05385875
8Staphylococcus aureus infection_Homo sapiens_hsa051501.97026182
9Circadian rhythm_Homo sapiens_hsa047101.95650063
10Asthma_Homo sapiens_hsa053101.86477580
11Renin secretion_Homo sapiens_hsa049241.72173206
12GnRH signaling pathway_Homo sapiens_hsa049121.69571863
13Vascular smooth muscle contraction_Homo sapiens_hsa042701.68568245
14Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.64946517
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59697573
16Malaria_Homo sapiens_hsa051441.59662748
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.45893818
18Amoebiasis_Homo sapiens_hsa051461.43590418
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42363262
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.40444881
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39826920
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36973439
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.25903794
24Olfactory transduction_Homo sapiens_hsa047401.25145947
25Acute myeloid leukemia_Homo sapiens_hsa052211.16457525
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15568330
27Adherens junction_Homo sapiens_hsa045201.12411577
28Long-term potentiation_Homo sapiens_hsa047201.12212461
29Linoleic acid metabolism_Homo sapiens_hsa005911.10886759
30Phenylalanine metabolism_Homo sapiens_hsa003601.09774588
31Chemical carcinogenesis_Homo sapiens_hsa052041.08103623
32Tuberculosis_Homo sapiens_hsa051521.05101812
33Chemokine signaling pathway_Homo sapiens_hsa040621.04239932
34Tight junction_Homo sapiens_hsa045301.02050633
35Insulin signaling pathway_Homo sapiens_hsa049100.97168476
36Glutathione metabolism_Homo sapiens_hsa004800.94136390
37Ras signaling pathway_Homo sapiens_hsa040140.93416628
38Graft-versus-host disease_Homo sapiens_hsa053320.93033751
39VEGF signaling pathway_Homo sapiens_hsa043700.89967373
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89243521
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87802015
42Autoimmune thyroid disease_Homo sapiens_hsa053200.87783615
43Gastric acid secretion_Homo sapiens_hsa049710.86095056
44Influenza A_Homo sapiens_hsa051640.85497775
45Histidine metabolism_Homo sapiens_hsa003400.85491723
46Allograft rejection_Homo sapiens_hsa053300.85471573
47Retinol metabolism_Homo sapiens_hsa008300.84705455
48Endocytosis_Homo sapiens_hsa041440.82979186
49Oxytocin signaling pathway_Homo sapiens_hsa049210.82785544
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81213091
51Glucagon signaling pathway_Homo sapiens_hsa049220.79859722
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77469309
53Notch signaling pathway_Homo sapiens_hsa043300.76218990
54Glioma_Homo sapiens_hsa052140.75668368
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74430720
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.73854506
57Calcium signaling pathway_Homo sapiens_hsa040200.71679331
58Melanogenesis_Homo sapiens_hsa049160.70545255
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70412666
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.69975434
61Rheumatoid arthritis_Homo sapiens_hsa053230.69218599
62Axon guidance_Homo sapiens_hsa043600.69172596
63Dorso-ventral axis formation_Homo sapiens_hsa043200.66012620
64Rap1 signaling pathway_Homo sapiens_hsa040150.65861694
65Salmonella infection_Homo sapiens_hsa051320.65466775
66Serotonergic synapse_Homo sapiens_hsa047260.63566696
67Phagosome_Homo sapiens_hsa041450.62594730
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.62301958
69Hepatitis C_Homo sapiens_hsa051600.61982949
70Systemic lupus erythematosus_Homo sapiens_hsa053220.60816564
71Dilated cardiomyopathy_Homo sapiens_hsa054140.60651395
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60339845
73Tyrosine metabolism_Homo sapiens_hsa003500.59664759
74Collecting duct acid secretion_Homo sapiens_hsa049660.58668629
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58570719
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57613329
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56641736
78Pancreatic secretion_Homo sapiens_hsa049720.54902021
79Leishmaniasis_Homo sapiens_hsa051400.54729570
80Thyroid cancer_Homo sapiens_hsa052160.54127435
81Viral myocarditis_Homo sapiens_hsa054160.53816052
82Type I diabetes mellitus_Homo sapiens_hsa049400.53066901
83Toxoplasmosis_Homo sapiens_hsa051450.53056316
84Sphingolipid metabolism_Homo sapiens_hsa006000.52997866
85cAMP signaling pathway_Homo sapiens_hsa040240.52555128
86beta-Alanine metabolism_Homo sapiens_hsa004100.52319099
87Ether lipid metabolism_Homo sapiens_hsa005650.51131901
88Estrogen signaling pathway_Homo sapiens_hsa049150.51106622
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49933203
90Cardiac muscle contraction_Homo sapiens_hsa042600.49474884
91Circadian entrainment_Homo sapiens_hsa047130.48170907
92Synaptic vesicle cycle_Homo sapiens_hsa047210.47595580
93PPAR signaling pathway_Homo sapiens_hsa033200.47188790
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46769946
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46490919
96Platelet activation_Homo sapiens_hsa046110.46214274
97MAPK signaling pathway_Homo sapiens_hsa040100.45459333
98Ovarian steroidogenesis_Homo sapiens_hsa049130.44839833
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43059631
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42880002

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