SPINK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)9.66096384
2cerebellar granule cell differentiation (GO:0021707)7.99829818
3protein heterotetramerization (GO:0051290)7.73555968
4cerebellar Purkinje cell layer development (GO:0021680)6.99382752
5fructose metabolic process (GO:0006000)6.83228849
6cGMP-mediated signaling (GO:0019934)6.05760443
7cerebellar Purkinje cell differentiation (GO:0021702)6.05395884
8metanephric nephron tubule development (GO:0072234)5.96327528
9metanephric tubule development (GO:0072170)5.96327528
10C4-dicarboxylate transport (GO:0015740)5.91026501
11prepulse inhibition (GO:0060134)5.83310325
12gamma-aminobutyric acid signaling pathway (GO:0007214)5.82531998
13cellular response to lithium ion (GO:0071285)5.70669820
14collecting duct development (GO:0072044)5.70544912
15homocysteine metabolic process (GO:0050667)5.63155222
16inositol phosphate-mediated signaling (GO:0048016)5.53756128
17cellular response to vitamin D (GO:0071305)5.43088648
18positive regulation of vascular permeability (GO:0043117)5.42151862
19metanephric nephron epithelium development (GO:0072243)5.40797427
20positive regulation of muscle hypertrophy (GO:0014742)5.33964196
21positive regulation of cardiac muscle hypertrophy (GO:0010613)5.33964196
22cell differentiation in hindbrain (GO:0021533)5.15049825
23response to histamine (GO:0034776)5.13382189
24cellular sodium ion homeostasis (GO:0006883)5.05050663
25neurofilament cytoskeleton organization (GO:0060052)5.02001521
26musculoskeletal movement (GO:0050881)5.01963311
27multicellular organismal movement (GO:0050879)5.01963311
28cardiac right ventricle morphogenesis (GO:0003215)4.96428564
29cellular response to vitamin (GO:0071295)4.96115914
30regulation of metalloenzyme activity (GO:0048552)4.95800628
31metanephric epithelium development (GO:0072207)4.92094724
32cellular potassium ion homeostasis (GO:0030007)4.88800395
33positive regulation of synaptic transmission, GABAergic (GO:0032230)4.83892968
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.82071459
35vitamin D metabolic process (GO:0042359)4.80936817
36regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.78307372
37negative regulation of T cell differentiation in thymus (GO:0033085)4.72214994
38positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.67605052
39vitamin catabolic process (GO:0009111)4.65975035
40fat-soluble vitamin catabolic process (GO:0042363)4.65975035
41tooth mineralization (GO:0034505)4.57225925
42regulation of integrin-mediated signaling pathway (GO:2001044)4.56741478
43aggressive behavior (GO:0002118)4.52513208
44opsonization (GO:0008228)4.49636511
45ionotropic glutamate receptor signaling pathway (GO:0035235)4.44858598
46regulation of vitamin D biosynthetic process (GO:0060556)4.43154861
47negative regulation of viral entry into host cell (GO:0046597)4.42779790
48positive regulation of glomerulus development (GO:0090193)4.37710413
49retina layer formation (GO:0010842)4.37079701
50negative regulation of fatty acid transport (GO:2000192)4.35738657
51endoplasmic reticulum calcium ion homeostasis (GO:0032469)4.31007970
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26776764
53positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.25701426
54sulfate transmembrane transport (GO:1902358)4.22493142
55neuron-neuron synaptic transmission (GO:0007270)4.18054396
56peptidyl-proline hydroxylation (GO:0019511)4.14481259
57sodium ion export (GO:0071436)4.08782237
58regulation of vitamin metabolic process (GO:0030656)4.07671866
59cGMP metabolic process (GO:0046068)4.00704544
60iron ion import (GO:0097286)3.97358042
61glutamate receptor signaling pathway (GO:0007215)3.96199822
62cAMP-mediated signaling (GO:0019933)3.95867137
63urate metabolic process (GO:0046415)3.93858352
64positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.93622283
65G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.91480724
664-hydroxyproline metabolic process (GO:0019471)3.90169848
67negative regulation of norepinephrine secretion (GO:0010700)3.89785741
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.89562195
69cysteine metabolic process (GO:0006534)3.87152826
70proline metabolic process (GO:0006560)3.87137882
71relaxation of smooth muscle (GO:0044557)3.82323787
72cytoskeletal anchoring at plasma membrane (GO:0007016)3.79371227
73energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74603331
74ATP synthesis coupled proton transport (GO:0015986)3.74603331
75bone trabecula formation (GO:0060346)3.72919207
76layer formation in cerebral cortex (GO:0021819)3.71405327
77keratinocyte proliferation (GO:0043616)3.70554143
78response to folic acid (GO:0051593)3.65852829
79regulation of potassium ion transmembrane transporter activity (GO:1901016)3.65652761
80negative regulation of vascular permeability (GO:0043116)3.65573191
81import into cell (GO:0098657)3.65317734
82cartilage morphogenesis (GO:0060536)3.65082934
83behavioral response to nicotine (GO:0035095)3.61767909
84drug transmembrane transport (GO:0006855)3.60426025
85L-ascorbic acid metabolic process (GO:0019852)3.59051064
86regulation of apoptotic process involved in morphogenesis (GO:1902337)3.52997869
87synaptic transmission, glutamatergic (GO:0035249)3.52446276
88positive regulation of dendritic spine morphogenesis (GO:0061003)3.51744091
89regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.51017761
90regulation of tight junction assembly (GO:2000810)3.50923840
91mesenchymal-epithelial cell signaling (GO:0060638)3.50848863
92response to lithium ion (GO:0010226)3.44202415
93neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.43842781
94regulation of centriole replication (GO:0046599)3.42043066
95retinal cone cell development (GO:0046549)3.40617830
96cAMP catabolic process (GO:0006198)3.40124167
97sulfate transport (GO:0008272)3.37719119
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36853514
99negative regulation of heart rate (GO:0010459)3.35619426
100nephron tubule development (GO:0072080)3.32484008
101embryonic camera-type eye development (GO:0031076)3.28893664
102hemidesmosome assembly (GO:0031581)3.28505268
103hematopoietic stem cell proliferation (GO:0071425)3.28388697
104wound healing, spreading of epidermal cells (GO:0035313)3.27462998
105regulation of viral entry into host cell (GO:0046596)3.27225839
106cellular response to nutrient (GO:0031670)3.26026685
107positive regulation of endothelial cell apoptotic process (GO:2000353)3.23979049
108positive regulation of DNA-templated transcription, initiation (GO:2000144)3.23754408
109respiratory electron transport chain (GO:0022904)3.23241690
110cyclic nucleotide catabolic process (GO:0009214)3.21063373
111negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.19608448
112response to lipoprotein particle (GO:0055094)3.18501244
113fibril organization (GO:0097435)3.14337799
114peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.14001642
115electron transport chain (GO:0022900)3.11580703
116regulation of potassium ion transmembrane transport (GO:1901379)3.11487479
117sphingomyelin metabolic process (GO:0006684)3.10762538
118proline biosynthetic process (GO:0006561)3.09528566
119protein heterotrimerization (GO:0070208)3.09512353
120nephron tubule formation (GO:0072079)3.09383102
121long term synaptic depression (GO:0060292)3.05573863
122phosphate ion transmembrane transport (GO:0035435)3.05303706
123cyclic-nucleotide-mediated signaling (GO:0019935)3.05040753
124chemosensory behavior (GO:0007635)3.04889292
125response to water (GO:0009415)3.03019788
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02254500
127auditory receptor cell stereocilium organization (GO:0060088)3.01967902
128adhesion of symbiont to host cell (GO:0044650)3.01277627
129virion attachment to host cell (GO:0019062)3.01277627
130drug transport (GO:0015893)3.00132529
131hair cycle (GO:0042633)2.99745527
132molting cycle (GO:0042303)2.99745527
133dopamine biosynthetic process (GO:0042416)2.98284582
134renal tubule development (GO:0061326)2.96800845
135phospholipid scrambling (GO:0017121)2.96017213
136cellular response to glucagon stimulus (GO:0071377)2.95935807
137one-carbon metabolic process (GO:0006730)2.95832494
138regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.95282280
139positive regulation of nitric-oxide synthase activity (GO:0051000)2.94227927
140folic acid metabolic process (GO:0046655)2.94222282
141peptidyl-glutamic acid carboxylation (GO:0017187)2.94146308
142protein carboxylation (GO:0018214)2.94146308
143gluconeogenesis (GO:0006094)2.92497594
144protein retention in ER lumen (GO:0006621)2.91869108
145innervation (GO:0060384)2.91470911
146protein maturation by protein folding (GO:0022417)2.90550482
147response to vitamin D (GO:0033280)2.89530610
148positive regulation of amino acid transport (GO:0051957)2.88313925
149positive regulation of potassium ion transmembrane transport (GO:1901381)2.88023759
150negative regulation of response to reactive oxygen species (GO:1901032)2.87979887
151wound healing, spreading of cells (GO:0044319)2.87749529
152regulation of membrane protein ectodomain proteolysis (GO:0051043)2.87544041
153phosphate ion transport (GO:0006817)2.86330996
154cellular response to oxygen radical (GO:0071450)2.85569919
155removal of superoxide radicals (GO:0019430)2.85569919
156cellular response to superoxide (GO:0071451)2.85569919
157activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.85354468
158nonribosomal peptide biosynthetic process (GO:0019184)2.84398063
159aldehyde catabolic process (GO:0046185)2.83876296
160regulation of cell communication by electrical coupling (GO:0010649)2.83620091
161positive regulation of chemokine biosynthetic process (GO:0045080)2.83079236
162I-kappaB phosphorylation (GO:0007252)2.82280575
163retina vasculature morphogenesis in camera-type eye (GO:0061299)2.80692481
164positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80100271
165hemoglobin metabolic process (GO:0020027)2.79801097
166regulation of hydrogen peroxide-induced cell death (GO:1903205)2.77979458
167uronic acid metabolic process (GO:0006063)2.77501379
168glucuronate metabolic process (GO:0019585)2.77501379
169regulation of keratinocyte proliferation (GO:0010837)2.76890018
170mitochondrial respiratory chain complex I assembly (GO:0032981)2.76788894
171NADH dehydrogenase complex assembly (GO:0010257)2.76788894
172mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76788894
173neuronal action potential propagation (GO:0019227)2.75465772
174serotonin metabolic process (GO:0042428)2.74497877
175positive regulation of hair follicle development (GO:0051798)2.74465396
176positive regulation of hair cycle (GO:0042635)2.74465396
177intermediate filament organization (GO:0045109)2.74448564
178parturition (GO:0007567)2.74294488
179acidic amino acid transport (GO:0015800)2.73931387
180collagen fibril organization (GO:0030199)2.73190531
181apical protein localization (GO:0045176)2.72805373
182folic acid transport (GO:0015884)2.72709731
183glyoxylate metabolic process (GO:0046487)2.69580813
184epoxygenase P450 pathway (GO:0019373)2.67956917
185positive regulation of nitric oxide biosynthetic process (GO:0045429)2.66796101
186maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65931663
187organic cation transport (GO:0015695)2.65896223
188cellular glucuronidation (GO:0052695)2.64454206
189response to nitrosative stress (GO:0051409)2.63509236
190smooth muscle cell differentiation (GO:0051145)2.59695757
191positive regulation of extracellular matrix organization (GO:1903055)2.58771419
192positive regulation of actin filament depolymerization (GO:0030836)2.58543991
193protein hydroxylation (GO:0018126)2.58127901
194xenobiotic catabolic process (GO:0042178)2.56661720
195extracellular fibril organization (GO:0043206)2.56342487
196type B pancreatic cell proliferation (GO:0044342)2.56278507
197extracellular matrix assembly (GO:0085029)2.54150369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.88813457
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.48860797
3TRIM28_21343339_ChIP-Seq_HEK293_Human5.12515473
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.19292927
5RARG_19884340_ChIP-ChIP_MEFs_Mouse4.11094053
6TAF15_26573619_Chip-Seq_HEK293_Human3.84974355
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.72301425
8ZNF263_19887448_ChIP-Seq_K562_Human3.66194408
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.44842259
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.42019679
11SRY_22984422_ChIP-ChIP_TESTIS_Rat3.35462950
12ESR1_21235772_ChIP-Seq_MCF-7_Human3.33231265
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03924284
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.00145449
15GBX2_23144817_ChIP-Seq_PC3_Human2.87749789
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.79109441
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78661070
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55756656
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.44726491
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.44487284
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.39712656
22FUS_26573619_Chip-Seq_HEK293_Human2.33935320
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.32658645
24SREBP1_19666523_ChIP-Seq_LIVER_Mouse2.31778664
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.31142512
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19125988
27CJUN_26792858_Chip-Seq_BT549_Human2.09574382
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.06929103
29CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.05054115
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01990481
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.00039633
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91834898
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.86338722
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.86338722
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81063746
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80554912
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.76836409
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76127482
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73370128
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72803071
41CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.70787432
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65799533
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.64517849
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.63301941
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62362494
46CLOCK_20551151_ChIP-Seq_293T_Human1.61909499
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61689760
48EZH2_22144423_ChIP-Seq_EOC_Human1.60517464
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59568827
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59568827
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58486497
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58454930
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57288284
54CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.55935740
55* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54514875
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.53859967
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53652968
58SOX2_20726797_ChIP-Seq_SW620_Human1.53526211
59E2F7_22180533_ChIP-Seq_HELA_Human1.53431329
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52609422
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.45095003
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42375564
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41892480
64RXR_22108803_ChIP-Seq_LS180_Human1.39907212
65GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.38769014
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38003031
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38003031
68SOX9_26525672_Chip-Seq_HEART_Mouse1.37892124
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36930768
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33475332
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33368242
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33305614
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33236412
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.32983329
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31828647
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31515903
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30482782
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28236554
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25773166
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25228109
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25189104
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.24730525
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21966146
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21342889
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20955362
86MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20302547
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.20246023
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18948869
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18803587
90MYC_18940864_ChIP-ChIP_HL60_Human1.17967746
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17285674
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.16942547
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16826203
94VDR_24787735_ChIP-Seq_THP-1_Human1.15831097
95BRD4_25478319_ChIP-Seq_HGPS_Human1.15365701
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15327897
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15232891
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.15001305
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13779089
100EWS_26573619_Chip-Seq_HEK293_Human1.13400555
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.12298014
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.12199173
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10905518
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10400532
105PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09751390
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06609798
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06481159
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06376122
109TP53_18474530_ChIP-ChIP_U2OS_Human1.05861708
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05512733
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04979649
112HTT_18923047_ChIP-ChIP_STHdh_Human1.04187739
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03319525
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03248305
115P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02760013
116SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02757185
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.02437393
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02434420
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02433221
120TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02003686
121GATA2_21666600_ChIP-Seq_HMVEC_Human1.01293565
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00086284
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99098206
124AR_25329375_ChIP-Seq_VCAP_Human0.98983145
125REST_21632747_ChIP-Seq_MESCs_Mouse0.98784793
126EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98297585
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98209970
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97596988
129IRF8_21731497_ChIP-ChIP_J774_Mouse0.97511432
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97148779
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97049114
132VDR_22108803_ChIP-Seq_LS180_Human0.96830053
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96496957
134LXR_22292898_ChIP-Seq_THP-1_Human0.96133305
135E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94676548
136ETS1_20019798_ChIP-Seq_JURKAT_Human0.94432500
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94308505
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93692703
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92997823
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92919201
141DCP1A_22483619_ChIP-Seq_HELA_Human0.92828492
142MYC_19915707_ChIP-ChIP_AK7_Human0.92673222
143TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92183186
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91524534
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91443837
146CSB_26484114_Chip-Seq_FIBROBLAST_Human0.90656612
147GATA1_22025678_ChIP-Seq_K562_Human0.89766730
148ATF3_27146783_Chip-Seq_COLON_Human0.89739502
149REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88579263
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88566007
151HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87781776
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86503453
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86391770
154UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86004966
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.85528372
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84763903
157GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84301919
158BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83998513
159SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82286244
160SA1_27219007_Chip-Seq_ERYTHROID_Human0.81536440
161ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80620633
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79592877
163NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79187163
164TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76630799
165BMI1_23680149_ChIP-Seq_NPCS_Mouse0.75246777
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74045355
167* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73633695
168RNF2_27304074_Chip-Seq_ESCs_Mouse0.73228515
169EZH2_27304074_Chip-Seq_ESCs_Mouse0.72885871
170KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71621437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.98088324
2MP0002877_abnormal_melanocyte_morpholog5.29197908
3MP0008438_abnormal_cutaneous_collagen5.23420118
4MP0009046_muscle_twitch5.12781224
5MP0001958_emphysema5.01182832
6MP0002138_abnormal_hepatobiliary_system4.84927186
7MP0005623_abnormal_meninges_morphology4.68622966
8MP0004742_abnormal_vestibular_system4.62540052
9MP0003279_aneurysm4.40179624
10MP0009384_cardiac_valve_regurgitation4.19926557
11MP0006035_abnormal_mitochondrial_morpho4.09308130
12MP0000579_abnormal_nail_morphology4.04881123
13MP0001188_hyperpigmentation3.76420577
14MP0002272_abnormal_nervous_system3.52921664
15MP0005275_abnormal_skin_tensile3.40726953
16MP0005360_urolithiasis3.29031749
17MP0004019_abnormal_vitamin_homeostasis3.23553458
18MP0003300_gastrointestinal_ulcer3.08557255
19MP0008569_lethality_at_weaning2.98810178
20MP0002102_abnormal_ear_morphology2.86890026
21MP0001984_abnormal_olfaction2.75767363
22MP0003880_abnormal_central_pattern2.57379742
23MP0005503_abnormal_tendon_morphology2.45300061
24MP0005365_abnormal_bile_salt2.43751005
25MP0002139_abnormal_hepatobiliary_system2.41314213
26MP0001440_abnormal_grooming_behavior2.37766165
27MP0009840_abnormal_foam_cell2.26156257
28MP0003252_abnormal_bile_duct2.24614742
29MP0000003_abnormal_adipose_tissue2.22856582
30MP0003635_abnormal_synaptic_transmissio2.14166531
31MP0005332_abnormal_amino_acid2.08555603
32MP0005084_abnormal_gallbladder_morpholo2.04862888
33MP0004270_analgesia1.99753644
34MP0003806_abnormal_nucleotide_metabolis1.97937017
35MP0008874_decreased_physiological_sensi1.95157808
36MP0005409_darkened_coat_color1.94729311
37MP0002064_seizures1.88214504
38MP0003186_abnormal_redox_activity1.84452408
39MP0002067_abnormal_sensory_capabilities1.84335747
40MP0003724_increased_susceptibility_to1.77379751
41MP0003137_abnormal_impulse_conducting1.77257361
42MP0009643_abnormal_urine_homeostasis1.76296764
43MP0002295_abnormal_pulmonary_circulatio1.70640432
44MP0002638_abnormal_pupillary_reflex1.70414995
45MP0000358_abnormal_cell_content/1.67489456
46MP0002090_abnormal_vision1.63639600
47MP0002184_abnormal_innervation1.62224154
48MP0003191_abnormal_cellular_cholesterol1.59863367
49MP0003045_fibrosis1.57746862
50MP0002136_abnormal_kidney_physiology1.57447295
51MP0003786_premature_aging1.53288416
52MP0010307_abnormal_tumor_latency1.52844030
53MP0003879_abnormal_hair_cell1.52071312
54MP0005636_abnormal_mineral_homeostasis1.52003847
55MP0005423_abnormal_somatic_nervous1.51571965
56MP0001968_abnormal_touch/_nociception1.50182789
57MP0004036_abnormal_muscle_relaxation1.48184802
58MP0003195_calcinosis1.47437993
59MP0000343_altered_response_to1.44811003
60MP0004272_abnormal_basement_membrane1.43787177
61MP0004084_abnormal_cardiac_muscle1.43745903
62MP0001756_abnormal_urination1.42465593
63MP0004484_altered_response_of1.38908881
64MP0002168_other_aberrant_phenotype1.36980434
65MP0001765_abnormal_ion_homeostasis1.36102346
66MP0002060_abnormal_skin_morphology1.33999851
67MP0009745_abnormal_behavioral_response1.33827148
68MP0009764_decreased_sensitivity_to1.30121410
69MP0000750_abnormal_muscle_regeneration1.28387730
70MP0001299_abnormal_eye_distance/1.27471133
71MP0002063_abnormal_learning/memory/cond1.25226347
72MP0005165_increased_susceptibility_to1.24006139
73MP0005058_abnormal_lysosome_morphology1.23150698
74MP0003091_abnormal_cell_migration1.22025812
75MP0000566_synostosis1.19977538
76MP0004215_abnormal_myocardial_fiber1.18279823
77MP0002896_abnormal_bone_mineralization1.15818989
78MP0002933_joint_inflammation1.12545893
79MP0005410_abnormal_fertilization1.12086712
80MP0005023_abnormal_wound_healing1.11910527
81MP0003941_abnormal_skin_development1.08316589
82MP0002572_abnormal_emotion/affect_behav1.05813358
83MP0000013_abnormal_adipose_tissue1.04170237
84MP0001542_abnormal_bone_strength1.02245077
85MP0005595_abnormal_vascular_smooth1.01815230
86MP0001533_abnormal_skeleton_physiology1.01617890
87MP0002928_abnormal_bile_duct1.00329333
88MP0005220_abnormal_exocrine_pancreas0.99672705
89MP0000762_abnormal_tongue_morphology0.99472605
90MP0000537_abnormal_urethra_morphology0.98939619
91MP0003453_abnormal_keratinocyte_physiol0.98791484
92MP0003172_abnormal_lysosome_physiology0.98212647
93MP0004859_abnormal_synaptic_plasticity0.96251096
94MP0005501_abnormal_skin_physiology0.95376302
95MP0006054_spinal_hemorrhage0.94660422
96MP0005620_abnormal_muscle_contractility0.94372030
97MP0006072_abnormal_retinal_apoptosis0.93578963
98MP0003011_delayed_dark_adaptation0.93562343
99MP0005388_respiratory_system_phenotype0.92520652
100MP0002133_abnormal_respiratory_system0.92520652
101MP0008775_abnormal_heart_ventricle0.91741770
102MP0009379_abnormal_foot_pigmentation0.91206775
103MP0002734_abnormal_mechanical_nocicepti0.89824371
104MP0001486_abnormal_startle_reflex0.88906962
105MP0005257_abnormal_intraocular_pressure0.88012709
106MP0001177_atelectasis0.87425434
107MP0002160_abnormal_reproductive_system0.86748447
108MP0002735_abnormal_chemical_nociception0.85827458
109MP0003436_decreased_susceptibility_to0.85710893
110MP0001661_extended_life_span0.85407458
111MP0004811_abnormal_neuron_physiology0.82481641
112MP0000462_abnormal_digestive_system0.81738593
113MP0002066_abnormal_motor_capabilities/c0.81543560
114MP0000538_abnormal_urinary_bladder0.80886681
115MP0006276_abnormal_autonomic_nervous0.79932189
116MP0002998_abnormal_bone_remodeling0.79344552
117MP0005584_abnormal_enzyme/coenzyme_acti0.78801905
118MP0005508_abnormal_skeleton_morphology0.78090716
119MP0001243_abnormal_dermal_layer0.77837600
120MP0004858_abnormal_nervous_system0.77446316
121MP0002697_abnormal_eye_size0.77164669
122MP0002882_abnormal_neuron_morphology0.75809625
123MP0003638_abnormal_response/metabolism_0.75600130
124MP0001501_abnormal_sleep_pattern0.75077432
125MP0005670_abnormal_white_adipose0.74200738
126MP0005390_skeleton_phenotype0.73600535
127MP0000749_muscle_degeneration0.72854156
128MP0010368_abnormal_lymphatic_system0.71909717
129MP0008872_abnormal_physiological_respon0.71462170
130MP0002115_abnormal_skeleton_extremities0.71147673
131MP0005085_abnormal_gallbladder_physiolo0.69003993
132MP0002089_abnormal_postnatal_growth/wei0.68469878
133MP0004381_abnormal_hair_follicle0.66620631
134MP0000163_abnormal_cartilage_morphology0.66067211
135MP0005395_other_phenotype0.65941676
136MP0005384_cellular_phenotype0.65910229
137MP0010386_abnormal_urinary_bladder0.65331308
138MP0001727_abnormal_embryo_implantation0.64691870
139MP0002557_abnormal_social/conspecific_i0.64535491
140MP0009697_abnormal_copulation0.63085850
141MP0004085_abnormal_heartbeat0.62806159
142MP0002876_abnormal_thyroid_physiology0.61785828
143MP0010678_abnormal_skin_adnexa0.61673361
144MP0003566_abnormal_cell_adhesion0.60955820
145MP0000647_abnormal_sebaceous_gland0.60898090
146MP0000920_abnormal_myelination0.60641864
147MP0001849_ear_inflammation0.60541969
148MP0000569_abnormal_digit_pigmentation0.60301084
149MP0004233_abnormal_muscle_weight0.59938969
150MP0005166_decreased_susceptibility_to0.59806409
151MP0000377_abnormal_hair_follicle0.59417745
152MP0003385_abnormal_body_wall0.57282090
153MP0002405_respiratory_system_inflammati0.57109488
154MP0005164_abnormal_response_to0.57101694
155MP0002135_abnormal_kidney_morphology0.56324147
156MP0009250_abnormal_appendicular_skeleto0.55946440
157MP0003656_abnormal_erythrocyte_physiolo0.55361444
158MP0001915_intracranial_hemorrhage0.55266037
159MP0005621_abnormal_cell_physiology0.54615235
160MP0002098_abnormal_vibrissa_morphology0.54453545
161MP0003795_abnormal_bone_structure0.53825164
162MP0002229_neurodegeneration0.53535973
163MP0008007_abnormal_cellular_replicative0.52263696
164MP0002152_abnormal_brain_morphology0.51414069
165MP0001853_heart_inflammation0.51212691
166MP0003448_altered_tumor_morphology0.50942109
167MP0005375_adipose_tissue_phenotype0.50841977
168MP0004957_abnormal_blastocyst_morpholog0.50356365
169MP0000427_abnormal_hair_cycle0.49862053
170MP0004133_heterotaxia0.49859984
171MP0000858_altered_metastatic_potential0.49760456
172MP0008875_abnormal_xenobiotic_pharmacok0.49527220
173MP0000230_abnormal_systemic_arterial0.49265487
174MP0010234_abnormal_vibrissa_follicle0.48682097
175MP0002796_impaired_skin_barrier0.48193628
176MP0001970_abnormal_pain_threshold0.47904395
177MP0010771_integument_phenotype0.47657761
178MP0002971_abnormal_brown_adipose0.46711839

Predicted human phenotypes

RankGene SetZ-score
1Scanning speech (HP:0002168)8.60484061
2Atonic seizures (HP:0010819)8.56351294
3Dysmetric saccades (HP:0000641)8.13956351
4Febrile seizures (HP:0002373)7.68181886
5Action tremor (HP:0002345)7.67538534
6Myokymia (HP:0002411)6.70255068
7Horizontal nystagmus (HP:0000666)6.55645911
8Protrusio acetabuli (HP:0003179)6.29997520
9Dysdiadochokinesis (HP:0002075)6.22698384
10Absence seizures (HP:0002121)5.99844203
11Focal motor seizures (HP:0011153)5.70901396
12Arterial tortuosity (HP:0005116)5.39403678
13Vascular tortuosity (HP:0004948)5.27253598
14Premature rupture of membranes (HP:0001788)5.04417530
15Aortic aneurysm (HP:0004942)4.86392556
16Gaze-evoked nystagmus (HP:0000640)4.83555751
17Truncal ataxia (HP:0002078)4.72300459
18Postural tremor (HP:0002174)4.64632368
19Soft skin (HP:0000977)4.55345251
20Epileptic encephalopathy (HP:0200134)4.49935559
21Intention tremor (HP:0002080)4.38367420
22Acute necrotizing encephalopathy (HP:0006965)4.37867820
23Dialeptic seizures (HP:0011146)4.34959728
24Progressive cerebellar ataxia (HP:0002073)4.34659386
25Abnormal mitochondria in muscle tissue (HP:0008316)4.27196831
26Gout (HP:0001997)4.12300172
27Impaired vibration sensation in the lower limbs (HP:0002166)3.89997706
28Dysmetria (HP:0001310)3.88129070
29Wormian bones (HP:0002645)3.75357050
30Impaired smooth pursuit (HP:0007772)3.64987824
31Vertebral compression fractures (HP:0002953)3.64637046
32Neonatal death (HP:0003811)3.57681891
33Progressive macrocephaly (HP:0004481)3.57369796
34Homocystinuria (HP:0002156)3.53786440
35Abnormality of homocysteine metabolism (HP:0010919)3.53786440
36Peritonitis (HP:0002586)3.53629492
37Coxa vara (HP:0002812)3.49317017
38Fragile skin (HP:0001030)3.49246136
39Acute encephalopathy (HP:0006846)3.42128300
40Abnormality of saccadic eye movements (HP:0000570)3.39482320
41Overgrowth (HP:0001548)3.34022365
42Mitochondrial inheritance (HP:0001427)3.27890861
43Wrist flexion contracture (HP:0001239)3.22180833
44Cutaneous melanoma (HP:0012056)3.22149829
45Broad-based gait (HP:0002136)3.17154374
46Increased purine levels (HP:0004368)3.17028738
47Hyperuricemia (HP:0002149)3.17028738
48Cardiovascular calcification (HP:0011915)3.15054468
49Distal lower limb muscle weakness (HP:0009053)3.04489480
50Epidermoid cyst (HP:0200040)3.00998348
51Bladder diverticulum (HP:0000015)2.99007511
52Potter facies (HP:0002009)2.98248415
53Facial shape deformation (HP:0011334)2.98248415
54Dilatation of the ascending aorta (HP:0005111)2.98107525
55Increased serum pyruvate (HP:0003542)2.95573258
56Limb ataxia (HP:0002070)2.95302170
57Focal seizures (HP:0007359)2.95035838
58Cerebral edema (HP:0002181)2.91549358
59Polyuria (HP:0000103)2.90267467
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.89765893
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89765893
62Turricephaly (HP:0000262)2.88468909
63Abnormality of the corticospinal tract (HP:0002492)2.87687088
64Tubulointerstitial fibrosis (HP:0005576)2.85124709
65Spinal cord compression (HP:0002176)2.80960173
66Abnormality of purine metabolism (HP:0004352)2.79942780
67Abnormality of ocular smooth pursuit (HP:0000617)2.78306695
68Natal tooth (HP:0000695)2.72409745
69Hyperextensible skin (HP:0000974)2.67804037
70Osteolytic defects of the hand bones (HP:0009699)2.67713611
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.67713611
72Abnormality of the astrocytes (HP:0100707)2.67460604
73Astrocytoma (HP:0009592)2.67460604
74Abnormality of glycolysis (HP:0004366)2.66739475
75Aortic dissection (HP:0002647)2.66328391
76Abnormality of renal excretion (HP:0011036)2.65469482
77Increased CSF lactate (HP:0002490)2.62650131
78Abnormal urine output (HP:0012590)2.62538011
79Vascular calcification (HP:0004934)2.60844797
80Joint stiffness (HP:0001387)2.57764463
81Relative macrocephaly (HP:0004482)2.57586271
82Vacuolated lymphocytes (HP:0001922)2.56112874
83Ileus (HP:0002595)2.55230055
84Abnormality of nail color (HP:0100643)2.52014127
85Blue sclerae (HP:0000592)2.51708997
86Renal tubular acidosis (HP:0001947)2.48763788
87Reduced antithrombin III activity (HP:0001976)2.44812276
88Biconcave vertebral bodies (HP:0004586)2.43071763
89Unilateral renal agenesis (HP:0000122)2.43043751
90Atrophic scars (HP:0001075)2.42696153
91Squamous cell carcinoma (HP:0002860)2.39796531
92Hypomagnesemia (HP:0002917)2.31608967
93Enlarged kidneys (HP:0000105)2.31417820
94Thin bony cortex (HP:0002753)2.30863824
95Opisthotonus (HP:0002179)2.30622089
96Abnormality of sulfur amino acid metabolism (HP:0004339)2.29265463
97Increased hepatocellular lipid droplets (HP:0006565)2.29093230
98Axonal loss (HP:0003447)2.28647139
99Split foot (HP:0001839)2.27963681
100Elbow flexion contracture (HP:0002987)2.26155262
101Arthropathy (HP:0003040)2.24503654
102Limited elbow extension (HP:0001377)2.21711971
103Round ear (HP:0100830)2.20219914
104Dry hair (HP:0011359)2.20031300
105Abnormal hemoglobin (HP:0011902)2.19526587
106Proximal tubulopathy (HP:0000114)2.19224011
107Urinary glycosaminoglycan excretion (HP:0003541)2.19017495
108Mucopolysacchariduria (HP:0008155)2.19017495
109Impaired vibratory sensation (HP:0002495)2.16796620
110Gait ataxia (HP:0002066)2.16324132
111Bradycardia (HP:0001662)2.15565055
112Glycosuria (HP:0003076)2.15120613
113Abnormality of urine glucose concentration (HP:0011016)2.15120613
114Milia (HP:0001056)2.12931842
115Cervical subluxation (HP:0003308)2.10793740
116Abnormality of magnesium homeostasis (HP:0004921)2.10537642
117Termporal pattern (HP:0011008)2.08524500
118Insidious onset (HP:0003587)2.08524500
119Dysostosis multiplex (HP:0000943)2.07197713
120Spastic diplegia (HP:0001264)2.03934914
121Autoamputation (HP:0001218)2.03875195
122Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03312366
123Cerebellar atrophy (HP:0001272)2.02922854
124Wide cranial sutures (HP:0010537)2.02099999
125Hypophosphatemia (HP:0002148)2.01985450
126Advanced eruption of teeth (HP:0006288)2.00320669
127Metabolic alkalosis (HP:0200114)1.99027767
128Nail dystrophy (HP:0008404)1.98935070
129Hyperlipoproteinemia (HP:0010980)1.98796867
130Generalized tonic-clonic seizures (HP:0002069)1.98035187
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97471181
132Abnormality of alanine metabolism (HP:0010916)1.97471181
133Hyperalaninemia (HP:0003348)1.97471181
134Abnormality of nucleobase metabolism (HP:0010932)1.96816246
135Abnormality of the acetabulum (HP:0003170)1.96649907
136Abnormality of oral frenula (HP:0000190)1.96648648
137Distal lower limb amyotrophy (HP:0008944)1.95206397
138Short nail (HP:0001799)1.93912880
139Metaphyseal irregularity (HP:0003025)1.93709412
140Bowel diverticulosis (HP:0005222)1.93690715
141X-linked dominant inheritance (HP:0001423)1.92726235
142Hepatocellular necrosis (HP:0001404)1.91877389
143Increased intramyocellular lipid droplets (HP:0012240)1.91665457
144Abnormality of polysaccharide metabolism (HP:0011012)1.89845481
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89845481
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89845481
147Nephrolithiasis (HP:0000787)1.86878755
148Lipid accumulation in hepatocytes (HP:0006561)1.86691743
149Exercise intolerance (HP:0003546)1.86084461
150Short chin (HP:0000331)1.85889193
151Hypercalciuria (HP:0002150)1.85831672
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.84582211
153Respiratory failure (HP:0002878)1.84454296
154Ectopia lentis (HP:0001083)1.84396806
155Confusion (HP:0001289)1.83535344
156Beaking of vertebral bodies (HP:0004568)1.83500969
157Renal Fanconi syndrome (HP:0001994)1.83470451
158Plantar hyperkeratosis (HP:0007556)1.83459518
159Hypokalemic alkalosis (HP:0001949)1.83289084
160Leukodystrophy (HP:0002415)1.83038107
161Glioma (HP:0009733)1.82147815
162Infantile muscular hypotonia (HP:0008947)1.81829506
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81734728
164Chronic diarrhea (HP:0002028)1.80491312
165Muscle fiber splitting (HP:0003555)1.79472367
166Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79045595
167Methylmalonic aciduria (HP:0012120)1.78445733
168Status epilepticus (HP:0002133)1.77434300
169Selective tooth agenesis (HP:0001592)1.76682184
170Long toe (HP:0010511)1.75310787
171Cheilitis (HP:0100825)1.75079106
172Onycholysis (HP:0001806)1.74937915
173Congenital glaucoma (HP:0001087)1.73409885
174Abnormal delivery (HP:0001787)1.72520877
175Joint hemorrhage (HP:0005261)1.70660852
176Increased circulating renin level (HP:0000848)1.70414425
177Slow progression (HP:0003677)1.67191454
178Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64282483
179Abnormality of the tricuspid valve (HP:0001702)1.64105930
180Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.64044644
181Decreased activity of mitochondrial respiratory chain (HP:0008972)1.64044644
182Degeneration of anterior horn cells (HP:0002398)1.63526328
183Abnormality of the anterior horn cell (HP:0006802)1.63526328
184Fragile nails (HP:0001808)1.63326968
185Lactic acidosis (HP:0003128)1.59930108
186Aplasia cutis congenita (HP:0001057)1.57269678
187Hepatic necrosis (HP:0002605)1.51021922
188Intellectual disability, mild (HP:0001256)1.48597924
189Thick nail (HP:0001805)1.47585144
190Athetosis (HP:0002305)1.45840306
191Optic disc pallor (HP:0000543)1.45569127
192Dysarthria (HP:0001260)1.45444440
193Respiratory difficulties (HP:0002880)1.45285420
194Myocardial infarction (HP:0001658)1.44294344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K126.34615425
2PINK14.88505585
3EIF2AK14.68759993
4GRK54.19981214
5LATS24.04369792
6MST1R3.60501807
7MAPK73.59075204
8ERN13.35968957
9DAPK22.92752481
10CAMKK22.88486618
11ZAK2.85940333
12BLK2.67055515
13MYLK2.54470956
14PRPF4B2.53692641
15TESK12.48575357
16RPS6KA42.36098291
17INSRR2.18088752
18MET2.14817653
19BUB12.04251655
20TAOK21.97979931
21CSNK1G31.94006420
22LIMK11.92457858
23BRAF1.89325545
24NEK11.87348624
25PAK41.86965544
26PRKG21.85072574
27BRSK21.77813741
28PIM21.67651854
29CSNK1G21.64611932
30EPHB21.61829962
31RPS6KC11.57644118
32RPS6KL11.57644118
33WNK41.56878711
34TESK21.46730331
35DAPK31.46210051
36RPS6KB21.44840457
37OXSR11.43008289
38RPS6KA61.38581843
39PIK3CG1.38507536
40CSNK1G11.38035682
41FRK1.35260390
42MAP3K91.35091085
43PTK61.32658474
44LMTK21.24376865
45DDR21.24299033
46ILK1.22932209
47FER1.13917114
48NTRK11.13533562
49CDC71.12182306
50PBK1.11990660
51EPHB11.08185420
52TLK11.07392783
53LRRK21.00230677
54STK390.99187100
55EPHA30.97730127
56NME10.96307536
57TRIB30.93545538
58CAMK2B0.91879899
59ABL20.91319665
60FGFR40.89616015
61ERBB40.89079629
62TEC0.88274324
63CAMK2A0.87768889
64BRSK10.84683001
65MINK10.79867382
66CLK10.78289549
67STK100.77402526
68PTK20.76786008
69RAF10.75865987
70CHEK20.74638857
71MAP3K30.73380553
72NME20.73043011
73MAP2K10.72751250
74RPS6KA50.72748288
75MAP3K130.72035459
76TTK0.70782398
77CAMKK10.70364445
78PRKG10.69491402
79BMX0.69273515
80PRKCG0.68983150
81ROCK20.68764973
82TGFBR20.68086430
83MOS0.67206294
84AURKA0.66910016
85PAK30.65397393
86WNK30.64060609
87PDK10.64046807
88CAMK2G0.63441717
89DAPK10.63373438
90PDK20.61635190
91ARAF0.59314511
92NEK90.57709030
93NTRK30.57347708
94MAP3K140.57324086
95TSSK60.54644688
96RPS6KA20.54575097
97KDR0.53844780
98PRKCA0.53145304
99MAP3K80.52104639
100CSNK1A1L0.51836098
101BCKDK0.50617746
102PNCK0.49819236
103CCNB10.48168875
104MTOR0.47432455
105ROCK10.47043468
106CAMK2D0.46668297
107CASK0.46077784
108AKT20.45757974
109PLK10.45757830
110CDK30.44624927
111AURKB0.44594976
112CDK190.44192511
113STK160.44125193
114ATR0.43700659
115PRKCE0.41482271
116SIK10.40182478
117KSR20.38913892
118SCYL20.38280251
119ERBB20.37993214
120SRC0.36924844
121EIF2AK20.36681101
122RPS6KB10.36459179
123FLT30.34988054
124PRKD10.34764680
125PRKDC0.34164275
126IRAK30.34043779
127PDK30.33978918
128PDK40.33978918
129CDK60.33925136
130IRAK10.33465768
131MAPKAPK50.32302225
132PTK2B0.32049045
133MAPKAPK30.30846387
134EIF2AK30.30538637
135PAK10.30268766
136TTN0.30044093
137MKNK10.29732867
138INSR0.27610301
139CDK80.27060817
140WEE10.26858689
141TXK0.26771979
142MAPK120.26561798
143WNK10.22998417
144MUSK0.22967411
145PRKACA0.22408802
146CSNK1A10.22168892
147IGF1R0.21571813
148RPS6KA30.20901127
149CDK140.20711511
150TBK10.20368359
151CAMK10.20232547
152PAK20.20208423
153MAP3K20.19037244
154SGK30.18757938
155FYN0.18175624
156MAP2K40.18025355
157GSK3A0.17656011
158TAF10.16801263
159MAPK40.16508174

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.14853493
2Long-term depression_Homo sapiens_hsa047304.10935603
3GABAergic synapse_Homo sapiens_hsa047273.22426618
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.21880251
5Morphine addiction_Homo sapiens_hsa050323.21040112
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.91193736
7Oxidative phosphorylation_Homo sapiens_hsa001902.86586006
8Pentose phosphate pathway_Homo sapiens_hsa000302.81645294
9Vitamin digestion and absorption_Homo sapiens_hsa049772.79730035
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73967022
11Arginine and proline metabolism_Homo sapiens_hsa003302.65017344
12Glutamatergic synapse_Homo sapiens_hsa047242.63669938
13Alzheimers disease_Homo sapiens_hsa050102.53670522
14Mineral absorption_Homo sapiens_hsa049782.50741589
15Parkinsons disease_Homo sapiens_hsa050122.46390268
16Nicotine addiction_Homo sapiens_hsa050332.35086244
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24773565
18Circadian entrainment_Homo sapiens_hsa047132.21351897
19Long-term potentiation_Homo sapiens_hsa047202.04192237
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98808440
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.95670869
22Alcoholism_Homo sapiens_hsa050341.91377815
23Glutathione metabolism_Homo sapiens_hsa004801.89641010
24Steroid biosynthesis_Homo sapiens_hsa001001.85944618
25Taste transduction_Homo sapiens_hsa047421.85747102
26Fructose and mannose metabolism_Homo sapiens_hsa000511.85158358
27Systemic lupus erythematosus_Homo sapiens_hsa053221.84014757
28Huntingtons disease_Homo sapiens_hsa050161.80151930
29Cardiac muscle contraction_Homo sapiens_hsa042601.78984970
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.76798167
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73212119
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70676367
33Serotonergic synapse_Homo sapiens_hsa047261.64163919
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61677696
35Protein digestion and absorption_Homo sapiens_hsa049741.61535767
36Renin secretion_Homo sapiens_hsa049241.60334636
37Pyruvate metabolism_Homo sapiens_hsa006201.59132723
38One carbon pool by folate_Homo sapiens_hsa006701.53854139
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52480439
40Other glycan degradation_Homo sapiens_hsa005111.51454967
41Gap junction_Homo sapiens_hsa045401.49783229
42Malaria_Homo sapiens_hsa051441.48364699
43Dopaminergic synapse_Homo sapiens_hsa047281.44802046
44Sulfur metabolism_Homo sapiens_hsa009201.44487178
45Salivary secretion_Homo sapiens_hsa049701.43369648
46Lysosome_Homo sapiens_hsa041421.43180713
47Arginine biosynthesis_Homo sapiens_hsa002201.35514578
48Cholinergic synapse_Homo sapiens_hsa047251.31805059
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30663609
50Butanoate metabolism_Homo sapiens_hsa006501.29651527
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.29509558
52Biosynthesis of amino acids_Homo sapiens_hsa012301.26892456
53TNF signaling pathway_Homo sapiens_hsa046681.26472030
54Phagosome_Homo sapiens_hsa041451.24724937
55Peroxisome_Homo sapiens_hsa041461.20781417
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.19928313
57Caffeine metabolism_Homo sapiens_hsa002321.18002462
58Shigellosis_Homo sapiens_hsa051311.17360893
59Melanoma_Homo sapiens_hsa052181.15529898
60Focal adhesion_Homo sapiens_hsa045101.11449191
61Bile secretion_Homo sapiens_hsa049761.10745321
62ECM-receptor interaction_Homo sapiens_hsa045121.10470151
63Axon guidance_Homo sapiens_hsa043601.10441900
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09943423
65Histidine metabolism_Homo sapiens_hsa003401.07774977
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06813318
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05677048
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02235123
69Adherens junction_Homo sapiens_hsa045201.01658200
70Complement and coagulation cascades_Homo sapiens_hsa046101.00544487
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99625382
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.97254710
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.97040047
74Vibrio cholerae infection_Homo sapiens_hsa051100.95781461
75Rheumatoid arthritis_Homo sapiens_hsa053230.94374818
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92161106
77Carbon metabolism_Homo sapiens_hsa012000.91930209
78Chemical carcinogenesis_Homo sapiens_hsa052040.91605285
79Vitamin B6 metabolism_Homo sapiens_hsa007500.88994733
80Proteoglycans in cancer_Homo sapiens_hsa052050.88820480
81Renin-angiotensin system_Homo sapiens_hsa046140.87863845
82Starch and sucrose metabolism_Homo sapiens_hsa005000.87522223
83Pertussis_Homo sapiens_hsa051330.86868584
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86697823
85Fatty acid degradation_Homo sapiens_hsa000710.85428857
86Calcium signaling pathway_Homo sapiens_hsa040200.85324128
87Propanoate metabolism_Homo sapiens_hsa006400.83888856
88Estrogen signaling pathway_Homo sapiens_hsa049150.82809777
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82427876
90Tryptophan metabolism_Homo sapiens_hsa003800.80418424
91Platelet activation_Homo sapiens_hsa046110.80171964
92Leishmaniasis_Homo sapiens_hsa051400.78076120
93Olfactory transduction_Homo sapiens_hsa047400.77629839
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.77392204
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76359235
96Gastric acid secretion_Homo sapiens_hsa049710.75125140
97African trypanosomiasis_Homo sapiens_hsa051430.74397530
98p53 signaling pathway_Homo sapiens_hsa041150.74240893
99beta-Alanine metabolism_Homo sapiens_hsa004100.73745423
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72887003
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72657258
102Circadian rhythm_Homo sapiens_hsa047100.71047628
103Rap1 signaling pathway_Homo sapiens_hsa040150.70471063
104Oxytocin signaling pathway_Homo sapiens_hsa049210.70183226
105Thyroid hormone synthesis_Homo sapiens_hsa049180.69829575
106Protein export_Homo sapiens_hsa030600.69613489
107Arachidonic acid metabolism_Homo sapiens_hsa005900.69173724
108Pancreatic secretion_Homo sapiens_hsa049720.68695572
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68153536
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67469624
111Collecting duct acid secretion_Homo sapiens_hsa049660.66805971
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65780372
113Tuberculosis_Homo sapiens_hsa051520.64936431
114Salmonella infection_Homo sapiens_hsa051320.63792945
115Synaptic vesicle cycle_Homo sapiens_hsa047210.63361006
116Oocyte meiosis_Homo sapiens_hsa041140.62238624
117Folate biosynthesis_Homo sapiens_hsa007900.61721153
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61686844
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.61654105
120Hepatitis B_Homo sapiens_hsa051610.60728999
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60174716
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59775746
123Glycerolipid metabolism_Homo sapiens_hsa005610.59220928
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.57296999
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57026153
126DNA replication_Homo sapiens_hsa030300.56620856
127Glioma_Homo sapiens_hsa052140.55093544
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54683890
129Phenylalanine metabolism_Homo sapiens_hsa003600.52495543
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52278616
131PPAR signaling pathway_Homo sapiens_hsa033200.51459436
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51276337
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50952126
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50445023
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49973050
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49660646
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.49592799
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49310425
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49066120
140Cell cycle_Homo sapiens_hsa041100.48212767
141Fat digestion and absorption_Homo sapiens_hsa049750.45305160
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45295652
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.45193442
144Viral carcinogenesis_Homo sapiens_hsa052030.43338043
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.43218084
146Fatty acid elongation_Homo sapiens_hsa000620.42016718
147Non-small cell lung cancer_Homo sapiens_hsa052230.41920337
148Hepatitis C_Homo sapiens_hsa051600.39464562
149Prion diseases_Homo sapiens_hsa050200.38913526
150Tight junction_Homo sapiens_hsa045300.38626665
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38581614
152ABC transporters_Homo sapiens_hsa020100.38384194
153Staphylococcus aureus infection_Homo sapiens_hsa051500.38234498
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37871600
155Proteasome_Homo sapiens_hsa030500.37111464
156Sulfur relay system_Homo sapiens_hsa041220.36611538
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36200035
158Ribosome_Homo sapiens_hsa030100.32255806
159Amphetamine addiction_Homo sapiens_hsa050310.31343568
160Inositol phosphate metabolism_Homo sapiens_hsa005620.29942218
161Choline metabolism in cancer_Homo sapiens_hsa052310.29416814
162mTOR signaling pathway_Homo sapiens_hsa041500.28272895
163Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26759941
164Insulin secretion_Homo sapiens_hsa049110.26478657
165Nucleotide excision repair_Homo sapiens_hsa034200.25911109
166Amoebiasis_Homo sapiens_hsa051460.25489110
167GnRH signaling pathway_Homo sapiens_hsa049120.24756318
168Fatty acid biosynthesis_Homo sapiens_hsa000610.22910072
169Small cell lung cancer_Homo sapiens_hsa052220.22524885
170Glucagon signaling pathway_Homo sapiens_hsa049220.22336246
171Regulation of autophagy_Homo sapiens_hsa041400.21805393
172Purine metabolism_Homo sapiens_hsa002300.20681225
173Metabolic pathways_Homo sapiens_hsa011000.20295920
174Melanogenesis_Homo sapiens_hsa049160.17836567
175Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17479218
176Dilated cardiomyopathy_Homo sapiens_hsa054140.16713869
177Mismatch repair_Homo sapiens_hsa034300.15712974

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