SPINK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)8.52642101
2multicellular organismal water homeostasis (GO:0050891)8.52500881
3water homeostasis (GO:0030104)7.12265989
4skin morphogenesis (GO:0043589)6.82692897
5regulation of transforming growth factor beta1 production (GO:0032908)6.56352240
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.48375041
7keratinocyte differentiation (GO:0030216)6.23618269
8detection of bacterium (GO:0016045)6.00528676
9positive regulation of glomerulus development (GO:0090193)5.99222718
10lipoxygenase pathway (GO:0019372)5.96152391
11intermediate filament cytoskeleton organization (GO:0045104)5.87786410
12regulation of cell proliferation involved in kidney development (GO:1901722)5.78914299
13intermediate filament-based process (GO:0045103)5.70442512
14atrioventricular valve morphogenesis (GO:0003181)5.54190813
15sphingoid metabolic process (GO:0046519)5.21023237
16keratinocyte development (GO:0003334)5.17329891
17detection of other organism (GO:0098543)5.13664513
18regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.13549840
19endocardial cushion morphogenesis (GO:0003203)5.12370881
20fat-soluble vitamin catabolic process (GO:0042363)5.07368782
21vitamin catabolic process (GO:0009111)5.07368782
22* epidermal cell differentiation (GO:0009913)4.84034533
23peptide cross-linking (GO:0018149)4.81290400
24chondrocyte development (GO:0002063)4.79111625
25epidermis development (GO:0008544)4.74886682
26phosphatidylserine acyl-chain remodeling (GO:0036150)4.74417105
27fatty acid elongation (GO:0030497)4.71003569
28hair follicle morphogenesis (GO:0031069)4.70618241
29regulation of phospholipase A2 activity (GO:0032429)4.69088017
30regulation of ruffle assembly (GO:1900027)4.68472131
31keratinocyte proliferation (GO:0043616)4.63928412
32gap junction assembly (GO:0016264)4.63075859
33phosphatidylinositol acyl-chain remodeling (GO:0036149)4.56284105
34G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.48889244
35hemidesmosome assembly (GO:0031581)4.43009428
36chemical homeostasis within a tissue (GO:0048875)4.30862701
37regulation of glucocorticoid metabolic process (GO:0031943)4.28806352
38intermediate filament organization (GO:0045109)4.20308865
39molting cycle (GO:0042303)4.18618747
40hair cycle (GO:0042633)4.18618747
41regulation of glomerulus development (GO:0090192)4.16020783
42apical protein localization (GO:0045176)4.15215615
43sphingosine metabolic process (GO:0006670)4.12502449
44mesenchyme morphogenesis (GO:0072132)4.08184239
45long-chain fatty acid biosynthetic process (GO:0042759)4.03091828
46negative regulation of hormone biosynthetic process (GO:0032353)3.87849725
47negative regulation of hormone metabolic process (GO:0032351)3.87849725
48surfactant homeostasis (GO:0043129)3.85858892
49negative regulation of keratinocyte proliferation (GO:0010839)3.84193145
50phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.82460932
51polarized epithelial cell differentiation (GO:0030859)3.77439680
52phospholipid scrambling (GO:0017121)3.77233539
53regulation of natural killer cell differentiation (GO:0032823)3.77186958
54diol metabolic process (GO:0034311)3.72646341
55phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.72227577
56positive regulation of astrocyte differentiation (GO:0048711)3.69255127
57positive regulation of chondrocyte differentiation (GO:0032332)3.68684206
58defense response to fungus (GO:0050832)3.65895498
59heart valve morphogenesis (GO:0003179)3.63445983
60long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.61961462
61ectoderm development (GO:0007398)3.61415904
62positive regulation of cartilage development (GO:0061036)3.60735999
63lateral sprouting from an epithelium (GO:0060601)3.59087043
64glucosamine-containing compound catabolic process (GO:1901072)3.54797005
65positive regulation of transforming growth factor beta production (GO:0071636)3.54550919
66negative regulation of interleukin-17 production (GO:0032700)3.54435494
67regulation of male gonad development (GO:2000018)3.47432312
68negative regulation of stress fiber assembly (GO:0051497)3.42182323
69planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34514511
70positive regulation of epidermis development (GO:0045684)3.34371954
71G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.34049759
72positive regulation of monocyte chemotaxis (GO:0090026)3.32462753
73phosphatidylcholine acyl-chain remodeling (GO:0036151)3.32283139
74intestinal epithelial cell development (GO:0060576)3.31095104
75positive regulation of interleukin-8 secretion (GO:2000484)3.30530713
76negative regulation of cell fate specification (GO:0009996)3.26968183
77* epithelial cell differentiation (GO:0030855)3.26324016
78eyelid development in camera-type eye (GO:0061029)3.26072061
79positive regulation of epidermal cell differentiation (GO:0045606)3.25924463
80phospholipid efflux (GO:0033700)3.25534237
81positive regulation of odontogenesis (GO:0042482)3.25527669
82regulation of keratinocyte differentiation (GO:0045616)3.22453190
83positive regulation of osteoblast proliferation (GO:0033690)3.21139871
84positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.20733743
85sequestering of metal ion (GO:0051238)3.20123349
86positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.14764499
87antimicrobial humoral response (GO:0019730)3.11712515
88cyclooxygenase pathway (GO:0019371)3.09169803
89germ cell migration (GO:0008354)3.07890965
90asymmetric protein localization (GO:0008105)3.07091407
91fatty-acyl-CoA metabolic process (GO:0035337)3.06535485
92regulation of neuron projection regeneration (GO:0070570)3.04870726
93regulation of axon regeneration (GO:0048679)3.04870726
94molting cycle process (GO:0022404)3.03336114
95hair cycle process (GO:0022405)3.03336114
96regulation of apoptotic process involved in morphogenesis (GO:1902337)3.01835405
97linoleic acid metabolic process (GO:0043651)2.99864497
98cardiolipin metabolic process (GO:0032048)2.98885320
99gland morphogenesis (GO:0022612)2.98791907
100positive regulation of cholesterol efflux (GO:0010875)2.98365367
101neural crest cell development (GO:0014032)2.98333762
102regulation of keratinocyte proliferation (GO:0010837)2.93213283
103phosphatidylserine metabolic process (GO:0006658)2.92617891
104regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92365000
105positive regulation of collagen biosynthetic process (GO:0032967)2.89198699
106regulation of steroid hormone biosynthetic process (GO:0090030)2.83621732
107positive regulation of cholesterol transport (GO:0032376)2.82296857
108positive regulation of sterol transport (GO:0032373)2.82296857
109response to phenylpropanoid (GO:0080184)2.81485643
110lymph vessel development (GO:0001945)2.81229399
111epithelial cell differentiation involved in prostate gland development (GO:0060742)2.78189185
112negative regulation of interferon-gamma production (GO:0032689)2.78095841
113regulation of epidermis development (GO:0045682)2.77013291
114positive regulation of collagen metabolic process (GO:0010714)2.75978476
115transepithelial transport (GO:0070633)2.75735386
116defense response to Gram-negative bacterium (GO:0050829)2.75239358
117negative regulation of cell fate commitment (GO:0010454)2.74558858
118positive regulation of cellular amide metabolic process (GO:0034250)2.74408045
119regulation of interleukin-8 secretion (GO:2000482)2.74345043
120positive regulation of keratinocyte differentiation (GO:0045618)2.73426064
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.72106112
122ceramide biosynthetic process (GO:0046513)2.70650832
123regulation of hypersensitivity (GO:0002883)2.68673505
124positive regulation of p38MAPK cascade (GO:1900745)2.66416450
125icosanoid secretion (GO:0032309)2.65908986
126arachidonic acid secretion (GO:0050482)2.65908986
127hormone catabolic process (GO:0042447)2.64129766
128regulation of heart rate by cardiac conduction (GO:0086091)2.64008060
129positive regulation of male gonad development (GO:2000020)2.63779449
130localization within membrane (GO:0051668)2.63215546
131ventricular cardiac muscle cell action potential (GO:0086005)2.62262477
132regulation of epidermal cell differentiation (GO:0045604)2.61970378
133glutathione biosynthetic process (GO:0006750)2.59894625
134cell surface receptor signaling pathway involved in heart development (GO:0061311)2.59158071
135establishment of tissue polarity (GO:0007164)2.55082825
136establishment of planar polarity (GO:0001736)2.55082825
137regulation of collagen biosynthetic process (GO:0032965)2.53549582
138non-canonical Wnt signaling pathway (GO:0035567)2.53178145
139epithelium development (GO:0060429)2.50336197
140glandular epithelial cell differentiation (GO:0002067)2.49489588
141detection of external biotic stimulus (GO:0098581)2.48935645
142regulation of p38MAPK cascade (GO:1900744)2.43507035
143retinol metabolic process (GO:0042572)2.41789545
144regulation of T cell chemotaxis (GO:0010819)2.33952834
145positive regulation of T cell chemotaxis (GO:0010820)2.33952834
146cell communication involved in cardiac conduction (GO:0086065)2.33693320
147phospholipid catabolic process (GO:0009395)2.33296452
148one-carbon compound transport (GO:0019755)2.30185847
149alditol phosphate metabolic process (GO:0052646)2.30149727
150epithelial cell-cell adhesion (GO:0090136)2.26667979
151regulation of monocyte chemotaxis (GO:0090025)2.26104079
152epithelial cell maturation (GO:0002070)2.24887166
153response to fungus (GO:0009620)2.22869152
154negative regulation of bone mineralization (GO:0030502)2.19373497
155cell-cell junction assembly (GO:0007043)2.19156482
156polyol transport (GO:0015791)2.18427452
157cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.17218036
158skin development (GO:0043588)2.14749089
159desmosome organization (GO:0002934)14.5422728
160establishment of skin barrier (GO:0061436)14.0609046
161regulation of water loss via skin (GO:0033561)12.4911244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.01380561
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.41853387
3* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.78884061
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.58368960
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50854569
6P63_26484246_Chip-Seq_KERATINOCYTES_Human2.50450273
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.47422813
8AR_21572438_ChIP-Seq_LNCaP_Human2.41571948
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.23652796
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.21317076
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12199742
12TP63_17297297_ChIP-ChIP_HaCaT_Human11.2712651
13TCF4_18268006_ChIP-ChIP_LS174T_Human1.96183425
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.87787778
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.85061366
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.85061366
17TP53_18474530_ChIP-ChIP_U2OS_Human1.84126639
18* SOX2_20726797_ChIP-Seq_SW620_Human1.80199529
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67369205
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65093749
21* TP63_23658742_ChIP-Seq_EP156T_Human1.65048020
22ERG_20517297_ChIP-Seq_VCAP_Human1.63485896
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55451777
24BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.50252670
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47543058
26IGF1R_20145208_ChIP-Seq_DFB_Human1.43510642
27ZNF263_19887448_ChIP-Seq_K562_Human1.40695763
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35644337
29EGR1_19032775_ChIP-ChIP_M12_Human1.31967220
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31605240
31* RUNX1_27514584_Chip-Seq_MCF-7_Human1.31122439
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30755462
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25444884
34CJUN_26792858_Chip-Seq_BT549_Human1.22931811
35VDR_22108803_ChIP-Seq_LS180_Human1.21332246
36AHR_22903824_ChIP-Seq_MCF-7_Human1.21082866
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18970376
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.18689432
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.18236344
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16982782
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15746411
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.14794642
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14345339
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13299470
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13092783
46RBPJ_21746931_ChIP-Seq_IB4_Human1.12850825
47RXR_22108803_ChIP-Seq_LS180_Human1.12570958
48* KLF5_25053715_ChIP-Seq_YYC3_Human1.12478419
49* GATA4_25053715_ChIP-Seq_YYC3_Human1.12125129
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10004984
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09617139
52TAF15_26573619_Chip-Seq_HEK293_Human1.07742735
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.05805877
54BCAT_22108803_ChIP-Seq_LS180_Human1.05536464
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04799870
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.04360946
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03644372
58TCF4_22108803_ChIP-Seq_LS180_Human1.03479261
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00438323
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00152319
61* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99662181
62SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99301664
63RNF2_27304074_Chip-Seq_ESCs_Mouse0.98793529
64TP53_20018659_ChIP-ChIP_R1E_Mouse0.98792897
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97659951
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97368564
67EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97357112
68RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97357112
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95759576
70TP53_16413492_ChIP-PET_HCT116_Human0.95721039
71HTT_18923047_ChIP-ChIP_STHdh_Human0.95220528
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94827753
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94827753
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94827753
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94572271
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.93833319
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93440130
78CTCF_20526341_ChIP-Seq_ESCs_Human0.92881180
79AR_25329375_ChIP-Seq_VCAP_Human0.92023501
80HNFA_21074721_ChIP-Seq_CACO-2_Human0.91253401
81TP63_22573176_ChIP-Seq_HFKS_Human0.91121594
82BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90037343
83RACK7_27058665_Chip-Seq_MCF-7_Human0.89766891
84MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.89551587
85CEBPB_22108803_ChIP-Seq_LS180_Human0.89369392
86ATF3_27146783_Chip-Seq_COLON_Human0.89180111
87SMC4_20622854_ChIP-Seq_HELA_Human0.88571099
88E2F1_20622854_ChIP-Seq_HELA_Human0.87878873
89GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87861712
90SMAD3_21741376_ChIP-Seq_HESCs_Human0.87241397
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87013457
92MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86874748
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86829746
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.84958774
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84897586
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84482919
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84209615
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84069080
99P53_21459846_ChIP-Seq_SAOS-2_Human0.82548218
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82299596
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.80823777
102UBF1/2_26484160_Chip-Seq_HMECs_Human0.80697377
103GATA6_25053715_ChIP-Seq_YYC3_Human0.80558173
104GATA1_22025678_ChIP-Seq_K562_Human0.80499571
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79786542
106PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79647818
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79303866
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78895767
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78895767
110CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78719406
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78155183
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.77910949
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76964982
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76964982
115CBX2_27304074_Chip-Seq_ESCs_Mouse0.76394448
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76047174
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.76026594
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75686077
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73910683
120LXR_22158963_ChIP-Seq_LIVER_Mouse0.73509832
121TBL1_22424771_ChIP-Seq_293T_Human0.73497592
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.73487241
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73476422
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72848284
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72742366
126FOXH1_21741376_ChIP-Seq_EPCs_Human0.72591529
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.72105826
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71843305
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.71236627
130FOXH1_21741376_ChIP-Seq_ESCs_Human0.71079438
131WT1_19549856_ChIP-ChIP_CCG9911_Human0.71032969
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70782155
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.70337681
134* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.70267469
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.70260337
136GATA6_21074721_ChIP-Seq_CACO-2_Human0.69963380
137ETV1_20927104_ChIP-Seq_GIST48_Human0.69955619
138CTCF_27219007_Chip-Seq_Bcells_Human0.68736273
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.68195211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier8.48843060
2MP0003941_abnormal_skin_development5.65282848
3* MP0005275_abnormal_skin_tensile5.20873266
4MP0005451_abnormal_body_composition5.09010863
5* MP0005501_abnormal_skin_physiology5.00386682
6MP0000579_abnormal_nail_morphology4.78115723
7MP0004381_abnormal_hair_follicle3.92251257
8MP0002060_abnormal_skin_morphology3.42193864
9MP0004947_skin_inflammation3.14324438
10* MP0002098_abnormal_vibrissa_morphology3.09503099
11* MP0001216_abnormal_epidermal_layer3.03004532
12MP0000647_abnormal_sebaceous_gland2.93899236
13* MP0010771_integument_phenotype2.89193802
14* MP0010234_abnormal_vibrissa_follicle2.82501233
15MP0004885_abnormal_endolymph2.56818523
16MP0005377_hearing/vestibular/ear_phenot2.45348122
17MP0003878_abnormal_ear_physiology2.45348122
18* MP0000377_abnormal_hair_follicle2.45209917
19MP0004043_abnormal_pH_regulation2.43361640
20MP0005409_darkened_coat_color2.39591122
21MP0003191_abnormal_cellular_cholesterol2.39082628
22MP0001188_hyperpigmentation2.34574555
23MP0002009_preneoplasia2.30722309
24MP0002095_abnormal_skin_pigmentation2.28359416
25MP0003453_abnormal_keratinocyte_physiol2.23375876
26MP0000383_abnormal_hair_follicle2.14904516
27MP0001346_abnormal_lacrimal_gland2.09298740
28* MP0010678_abnormal_skin_adnexa2.01885158
29MP0002254_reproductive_system_inflammat1.84496114
30MP0004185_abnormal_adipocyte_glucose1.76480004
31MP0001191_abnormal_skin_condition1.73404818
32MP0009379_abnormal_foot_pigmentation1.61035653
33MP0000427_abnormal_hair_cycle1.55868121
34MP0000762_abnormal_tongue_morphology1.53564584
35MP0003566_abnormal_cell_adhesion1.52545070
36MP0000467_abnormal_esophagus_morphology1.50455095
37MP0003136_yellow_coat_color1.48772027
38* MP0009931_abnormal_skin_appearance1.46512305
39MP0005623_abnormal_meninges_morphology1.42081936
40MP0004134_abnormal_chest_morphology1.37620196
41MP0002249_abnormal_larynx_morphology1.36531184
42MP0004782_abnormal_surfactant_physiolog1.23208850
43* MP0000367_abnormal_coat/_hair1.22318907
44MP0009053_abnormal_anal_canal1.16828819
45MP0005187_abnormal_penis_morphology1.13636649
46MP0001243_abnormal_dermal_layer1.08593205
47MP0003705_abnormal_hypodermis_morpholog1.05920128
48MP0000015_abnormal_ear_pigmentation1.05576336
49MP0000566_synostosis1.04496633
50MP0001340_abnormal_eyelid_morphology1.03103445
51MP0005174_abnormal_tail_pigmentation0.97625063
52MP0009384_cardiac_valve_regurgitation0.96255970
53MP0003315_abnormal_perineum_morphology0.93159424
54MP0000465_gastrointestinal_hemorrhage0.92733591
55MP0004272_abnormal_basement_membrane0.92612376
56MP0001919_abnormal_reproductive_system0.88661000
57MP0002282_abnormal_trachea_morphology0.88197268
58MP0005508_abnormal_skeleton_morphology0.87808936
59MP0002166_altered_tumor_susceptibility0.87164766
60MP0005503_abnormal_tendon_morphology0.86499532
61MP0001873_stomach_inflammation0.85568159
62MP0002234_abnormal_pharynx_morphology0.85480308
63MP0009250_abnormal_appendicular_skeleto0.79129742
64MP0005367_renal/urinary_system_phenotyp0.78913803
65MP0000516_abnormal_urinary_system0.78913803
66MP0003755_abnormal_palate_morphology0.77634856
67MP0001851_eye_inflammation0.76729918
68MP0004264_abnormal_extraembryonic_tissu0.73012475
69MP0009780_abnormal_chondrocyte_physiolo0.71959952
70MP0000013_abnormal_adipose_tissue0.71037889
71MP0005075_abnormal_melanosome_morpholog0.69177949
72MP0010386_abnormal_urinary_bladder0.69071627
73* MP0001784_abnormal_fluid_regulation0.68743317
74MP0003950_abnormal_plasma_membrane0.67206721
75MP0000163_abnormal_cartilage_morphology0.67192313
76MP0005076_abnormal_cell_differentiation0.67030529
77MP0002111_abnormal_tail_morphology0.62516888
78MP0000627_abnormal_mammary_gland0.60859193
79MP0002006_tumorigenesis0.59241850
80MP0003385_abnormal_body_wall0.58447439
81MP0010030_abnormal_orbit_morphology0.56798447
82MP0001485_abnormal_pinna_reflex0.56431560
83MP0008789_abnormal_olfactory_epithelium0.54861917
84MP0005647_abnormal_sex_gland0.53162317
85MP0001177_atelectasis0.53082025
86MP0002090_abnormal_vision0.52047660
87MP0001984_abnormal_olfaction0.51237983
88MP0006054_spinal_hemorrhage0.48428605
89MP0003195_calcinosis0.47925716
90MP0000613_abnormal_salivary_gland0.47160912
91MP0002896_abnormal_bone_mineralization0.46742620
92MP0002877_abnormal_melanocyte_morpholog0.46424748
93MP0002115_abnormal_skeleton_extremities0.46131148
94MP0002109_abnormal_limb_morphology0.44926245
95MP0005666_abnormal_adipose_tissue0.44448489
96MP0000371_diluted_coat_color0.44410517
97MP0005375_adipose_tissue_phenotype0.42582343
98MP0004019_abnormal_vitamin_homeostasis0.42267254
99MP0000538_abnormal_urinary_bladder0.42024112
100MP0003935_abnormal_craniofacial_develop0.41226140
101MP0001186_pigmentation_phenotype0.41214532
102MP0003638_abnormal_response/metabolism_0.40565688
103MP0000470_abnormal_stomach_morphology0.40432573
104MP0003936_abnormal_reproductive_system0.40118004
105MP0000049_abnormal_middle_ear0.40046882
106MP0005394_taste/olfaction_phenotype0.39813149
107MP0005499_abnormal_olfactory_system0.39813149
108MP0005390_skeleton_phenotype0.39744730
109MP0002233_abnormal_nose_morphology0.37943039
110MP0002160_abnormal_reproductive_system0.35783826
111MP0008004_abnormal_stomach_pH0.34837746
112MP0003890_abnormal_embryonic-extraembry0.34123438
113MP0008961_abnormal_basal_metabolism0.33802016
114MP0005193_abnormal_anterior_eye0.33664042
115MP0010352_gastrointestinal_tract_polyps0.33236897
116MP0002277_abnormal_respiratory_mucosa0.32826112
117MP0003045_fibrosis0.32662590
118MP0005023_abnormal_wound_healing0.31982922
119MP0004197_abnormal_fetal_growth/weight/0.31579666
120MP0003300_gastrointestinal_ulcer0.30968962
121MP0002177_abnormal_outer_ear0.29435423
122MP0001299_abnormal_eye_distance/0.28977577
123MP0002075_abnormal_coat/hair_pigmentati0.28938831
124MP0002138_abnormal_hepatobiliary_system0.28763373
125MP0003795_abnormal_bone_structure0.28691417
126MP0002697_abnormal_eye_size0.28190838
127MP0003011_delayed_dark_adaptation0.27189610
128MP0003937_abnormal_limbs/digits/tail_de0.26626985
129MP0001666_abnormal_nutrient_absorption0.26621078
130MP0005248_abnormal_Harderian_gland0.26579022
131MP0001286_abnormal_eye_development0.23957254
132MP0001765_abnormal_ion_homeostasis0.21071944
133MP0000462_abnormal_digestive_system0.20522810
134MP0000432_abnormal_head_morphology0.18417391
135MP0009672_abnormal_birth_weight0.18204609
136MP0009333_abnormal_splenocyte_physiolog0.17773858
137MP0006138_congestive_heart_failure0.14499314
138MP0001756_abnormal_urination0.13896735
139MP0002108_abnormal_muscle_morphology0.13567270
140MP0002133_abnormal_respiratory_system0.13126533
141MP0005388_respiratory_system_phenotype0.13126533

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)8.11293827
2Hypotrichosis (HP:0001006)7.24987337
3Onycholysis (HP:0001806)7.22295481
4* Increased IgE level (HP:0003212)6.89691914
5Right ventricular cardiomyopathy (HP:0011663)6.87093319
6* Congenital ichthyosiform erythroderma (HP:0007431)6.41968956
7Alopecia of scalp (HP:0002293)6.29764759
8Abnormality of nail color (HP:0100643)6.10035187
9Woolly hair (HP:0002224)5.96331905
10Parakeratosis (HP:0001036)5.76203533
11Thick nail (HP:0001805)5.56441241
12Erythema (HP:0010783)5.55987706
13* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.28043507
14Absent eyelashes (HP:0000561)4.28250261
15Natal tooth (HP:0000695)4.25649112
16Concave nail (HP:0001598)4.15246604
17Ectropion (HP:0000656)4.07148607
18Abnormality of the phalanges of the 2nd finger (HP:0009541)4.06411551
19Pustule (HP:0200039)3.95659225
20Gangrene (HP:0100758)3.76752543
21Corneal erosion (HP:0200020)3.73380512
22Absent hair (HP:0002298)3.72752016
23Lip pit (HP:0100267)3.72396291
24Palmoplantar hyperkeratosis (HP:0000972)3.71086324
25Pruritus (HP:0000989)3.65779549
26Curly hair (HP:0002212)3.61364354
27Plantar hyperkeratosis (HP:0007556)3.59704936
28Palmar hyperkeratosis (HP:0010765)3.53862467
29Advanced eruption of teeth (HP:0006288)3.53216918
30Hypohidrosis (HP:0000966)3.50280378
31Hyporeflexia of lower limbs (HP:0002600)3.48090286
32Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.46304676
33Humeroradial synostosis (HP:0003041)3.40578027
34Synostosis involving the elbow (HP:0003938)3.40578027
35Conjunctival hamartoma (HP:0100780)3.33070150
36Premature ovarian failure (HP:0008209)3.32722232
37Sex reversal (HP:0012245)3.31762852
38Abnormal sex determination (HP:0012244)3.31762852
39Abnormality of the 2nd finger (HP:0004100)3.22353901
40Fragile nails (HP:0001808)3.21327003
41Abnormality of the phalanges of the 5th finger (HP:0004213)3.18089282
42Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.18021944
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.11755458
44Abnormality of secondary sexual hair (HP:0009888)3.10806580
45Abnormality of the axillary hair (HP:0100134)3.10806580
46Abnormal hair laboratory examination (HP:0003328)3.05937746
47Furrowed tongue (HP:0000221)3.04402061
48Abnormality of the middle phalanges of the toes (HP:0010183)3.03700204
49Distal lower limb muscle weakness (HP:0009053)3.01247867
50Ventricular tachycardia (HP:0004756)3.00258564
51Slow-growing hair (HP:0002217)2.94582804
52Abnormality of hair growth rate (HP:0011363)2.94582804
53Reticulocytopenia (HP:0001896)2.91160337
54Palmoplantar keratoderma (HP:0000982)2.90335417
55Anhidrosis (HP:0000970)2.87878982
56Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.81716600
57Abnormal blistering of the skin (HP:0008066)2.78876101
58Follicular hyperkeratosis (HP:0007502)2.75751770
59Oligodactyly (HP:0012165)2.75188743
60Abnormality of the gastric mucosa (HP:0004295)2.73686097
61* Erythroderma (HP:0001019)2.70000873
62Sparse eyelashes (HP:0000653)2.64754838
63Blepharitis (HP:0000498)2.62766189
64Short hallux (HP:0010109)2.61760978
65Aplasia involving bones of the extremities (HP:0009825)2.57071335
66Aplasia involving bones of the upper limbs (HP:0009823)2.57071335
67Aplasia of the phalanges of the hand (HP:0009802)2.57071335
68Lack of skin elasticity (HP:0100679)2.54250800
69Amniotic constriction ring (HP:0009775)2.49560065
70Abnormality of placental membranes (HP:0011409)2.49560065
71Milia (HP:0001056)2.41081101
72* Sparse scalp hair (HP:0002209)2.39250781
73Eczematoid dermatitis (HP:0000976)2.38945220
74Nail dystrophy (HP:0008404)2.38035113
75Aplasia/Hypoplasia of the hallux (HP:0008362)2.31014916
76Popliteal pterygium (HP:0009756)2.30499657
77Bronchomalacia (HP:0002780)2.30467896
78Oligodontia (HP:0000677)2.27138482
79* Dry skin (HP:0000958)2.26821777
80Hamartoma of the eye (HP:0010568)2.19510139
81Autoamputation (HP:0001218)2.18783197
82Ridged nail (HP:0001807)2.14525998
83Hypoplastic nipples (HP:0002557)2.10631985
84Ventricular fibrillation (HP:0001663)2.08791392
85Laryngomalacia (HP:0001601)2.08634797
86Hyperhidrosis (HP:0000975)2.08454710
87Melanocytic nevus (HP:0000995)2.08350368
88Areflexia of lower limbs (HP:0002522)2.08266530
89Exocrine pancreatic insufficiency (HP:0001738)2.06783734
90Dry hair (HP:0011359)2.06088500
91Hyperactive renin-angiotensin system (HP:0000841)2.05270302
92Malignant hyperthermia (HP:0002047)2.01891193
93Aplasia/hypoplasia of the uterus (HP:0008684)2.01663675
94* Brittle hair (HP:0002299)2.01347071
95Abnormality of permanent molar morphology (HP:0011071)2.00749087
96Abnormality of the dental root (HP:0006486)2.00749087
97Taurodontia (HP:0000679)2.00749087
98Hyperparathyroidism (HP:0000843)2.00327464
99Split foot (HP:0001839)1.99128351
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99122735
101* Acanthosis nigricans (HP:0000956)1.98829135
1022-3 toe syndactyly (HP:0004691)1.97922139
103Hypoplastic labia majora (HP:0000059)1.95616524
104Labial hypoplasia (HP:0000066)1.95159991
105* Dehydration (HP:0001944)1.94531369
106Congenital, generalized hypertrichosis (HP:0004540)1.92658352
107Achilles tendon contracture (HP:0001771)1.92292207
10811 pairs of ribs (HP:0000878)1.87260714
109Abnormality of molar morphology (HP:0011070)1.86261494
110Abnormality of molar (HP:0011077)1.86261494
111Corneal dystrophy (HP:0001131)1.84913235
112Neonatal short-limb short stature (HP:0008921)1.82973385
113Nasolacrimal duct obstruction (HP:0000579)1.81920675
114Conical tooth (HP:0000698)1.81796988
115Hypoplasia of the iris (HP:0007676)1.81724717
116Chronic bronchitis (HP:0004469)1.81345734
117Recurrent corneal erosions (HP:0000495)1.81345378
118Bifid scrotum (HP:0000048)1.81084273
119Abnormality of the Achilles tendon (HP:0005109)1.80229420
120Abnormality of the dental pulp (HP:0006479)1.78695765
121* Hypergammaglobulinemia (HP:0010702)1.78511780
122Hypoplastic female external genitalia (HP:0012815)1.78442719
123Thickened helices (HP:0000391)1.76830152
124Hyperkalemia (HP:0002153)1.75786347
125Pili torti (HP:0003777)1.75624316
126Anonychia (HP:0001798)1.74924771
127Abnormality of the labia majora (HP:0012881)1.73763179
128Selective tooth agenesis (HP:0001592)1.72951874
129Multifactorial inheritance (HP:0001426)1.71660405
130Severe Myopia (HP:0011003)1.69076685
131Macular degeneration (HP:0000608)1.68859964
132Hypoplasia of the uterus (HP:0000013)1.68454753
133Pterygium (HP:0001059)1.68158724
134Sudden death (HP:0001699)1.67274468
135* Fine hair (HP:0002213)1.66955111
136Ulnar claw (HP:0001178)1.66759356
137Everted lower lip vermilion (HP:0000232)1.65501339
138Broad hallux (HP:0010055)1.65396695
139Sepsis (HP:0100806)1.64978872
140Septate vagina (HP:0001153)1.62338937
141Down-sloping shoulders (HP:0200021)1.62143991
142Abnormality of the salivary glands (HP:0010286)1.62090107
143Abnormality of the lacrimal duct (HP:0011481)1.54467915
144Duplicated collecting system (HP:0000081)1.53089214
145Carious teeth (HP:0000670)1.52395998
146Depressed nasal tip (HP:0000437)1.50980935
147Skin ulcer (HP:0200042)1.48362115
148Absent eyebrow (HP:0002223)1.47799430
149Abnormality of the fingernails (HP:0001231)1.47577352
150Hamartoma (HP:0010566)1.45027839
151Nonprogressive disorder (HP:0003680)1.44389355
152Xerostomia (HP:0000217)1.43251276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.25994065
2BCR4.54852779
3MAPKAPK34.37884645
4TGFBR14.31455112
5FER3.61753772
6LATS13.06307308
7MUSK3.04291226
8MST1R2.83475947
9GRK12.54189650
10EPHB22.24869604
11WNK12.22330348
12RPS6KB22.07414304
13RIPK11.89260755
14MAP3K21.85258702
15MAP3K31.75426710
16PIM21.75085982
17SGK2231.71321266
18SGK4941.71321266
19LRRK21.71231334
20ERN11.71224210
21IRAK31.67536291
22TRPM71.67110014
23EPHA31.64663160
24STK241.59369100
25EPHA41.59280376
26STK391.53156838
27STK101.51663014
28PTK61.46979313
29SGK21.37903812
30CAMK1D1.35696214
31PIK3CG1.31751811
32CAMK1G1.26479433
33PKN11.25609706
34STK38L1.25325344
35WNK41.23663000
36TYRO31.23075956
37DMPK1.19713616
38SGK31.19681991
39MAP3K91.15049325
40MARK21.14544524
41NME11.13882253
42EPHB11.12196368
43FGFR41.11723778
44HIPK21.09652997
45MAP3K71.05234438
46PBK1.04697211
47OXSR11.04571560
48BMPR1B1.04303405
49ERBB31.02357361
50MAPK70.99425575
51MAPKAPK50.99113027
52MAP3K120.96678280
53ROCK10.96578134
54EPHA20.95247790
55ABL20.94944959
56RPS6KB10.93551799
57MAP3K140.91921216
58LATS20.91337914
59FGFR20.88016350
60DYRK1B0.87649806
61PAK30.87148575
62BMPR20.85365164
63CDK60.82346582
64ITK0.81981908
65NUAK10.81740064
66PDGFRB0.80838565
67PDK20.78858749
68IRAK10.77327043
69STK30.76338650
70FGFR10.76037754
71CASK0.73953386
72ERBB40.70368185
73BLK0.69159185
74YES10.66837272
75DYRK30.65172592
76MAP2K60.63746306
77PRKAA20.62178193
78CSNK1D0.61926749
79MINK10.61524374
80PRKCE0.61336394
81FGFR30.61234481
82MTOR0.60686875
83GRK60.59626119
84ADRBK10.59233092
85SGK10.57106033
86EEF2K0.56399430
87MAP2K40.55327167
88TTN0.53755977
89CDK190.53313211
90NLK0.52134344
91SYK0.51799878
92PRKD10.50888842
93INSRR0.50221515
94SIK10.50167309
95RIPK40.49912507
96MAP3K10.49313830
97ROCK20.48325999
98ERBB20.47206413
99MAPK110.46630665
100MET0.44637459
101MAP3K110.44627148
102LMTK20.43630833
103PRKCI0.42503439
104AKT30.42080559
105IRAK20.40999645
106CSNK1E0.40809278
107MAPK120.40691801
108STK110.39523290
109MARK10.39131395
110TESK10.38751934
111MAPKAPK20.37792916
112GRK50.37649127
113OBSCN0.36902519
114MAPK90.36569220
115TAF10.36282854
116PRKD20.35825853
117PTK20.33685844
118TGFBR20.33682063
119TNK20.33250350
120RPS6KA10.33244793
121PRKCQ0.32184804
122NEK90.31924186
123MAPK100.31426326
124RPS6KC10.31357490
125RPS6KL10.31357490
126TAOK30.31089541
127AURKA0.30995251
128PRKACG0.28069346
129STK160.27601386
130MAP3K60.27423449
131CDK30.26751238
132CDK50.26412649
133RPS6KA20.26408661
134TAOK10.26214754
135STK380.26207852
136PDGFRA0.26151610
137PRKCA0.26090096
138MAPK40.25969262
139JAK20.25750180
140MAP2K10.25711253
141MAP3K40.24543374
142IKBKB0.24537993
143JAK10.24512208
144WNK30.24508849
145MAPK30.24379147
146FRK0.23398109
147PRKCB0.23232787
148CHUK0.22332141
149AKT20.21798894
150BMX0.19278542
151MAPK80.18973166
152CAMK10.18932022
153IKBKE0.15963749

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.31723967
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.74101053
3Fatty acid elongation_Homo sapiens_hsa000623.18590792
4Sphingolipid metabolism_Homo sapiens_hsa006003.12948755
5Retinol metabolism_Homo sapiens_hsa008302.50829768
6ABC transporters_Homo sapiens_hsa020102.14813661
7Basal cell carcinoma_Homo sapiens_hsa052171.95417193
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93356434
9Tight junction_Homo sapiens_hsa045301.92698753
10Ovarian steroidogenesis_Homo sapiens_hsa049131.90204767
11TGF-beta signaling pathway_Homo sapiens_hsa043501.89374306
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87079953
13Linoleic acid metabolism_Homo sapiens_hsa005911.85379677
14Arachidonic acid metabolism_Homo sapiens_hsa005901.80868878
15Adherens junction_Homo sapiens_hsa045201.65916086
16Ribosome_Homo sapiens_hsa030101.65756857
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61208420
18Histidine metabolism_Homo sapiens_hsa003401.60638905
19Melanoma_Homo sapiens_hsa052181.56264112
20Long-term depression_Homo sapiens_hsa047301.55929982
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54769254
22Collecting duct acid secretion_Homo sapiens_hsa049661.49678630
23Hippo signaling pathway_Homo sapiens_hsa043901.40016571
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.35224761
25Axon guidance_Homo sapiens_hsa043601.35152451
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32664410
27Melanogenesis_Homo sapiens_hsa049161.32536651
28Phototransduction_Homo sapiens_hsa047441.26056140
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.25483689
30Sulfur metabolism_Homo sapiens_hsa009201.17466054
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12982495
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08476244
33Ras signaling pathway_Homo sapiens_hsa040141.08180821
34Ether lipid metabolism_Homo sapiens_hsa005651.06861480
35Notch signaling pathway_Homo sapiens_hsa043301.02171492
36Choline metabolism in cancer_Homo sapiens_hsa052310.98761277
37Hedgehog signaling pathway_Homo sapiens_hsa043400.96169180
38Rap1 signaling pathway_Homo sapiens_hsa040150.95546192
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92633453
40Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92486069
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92284323
42Proteoglycans in cancer_Homo sapiens_hsa052050.90967705
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90233554
44ErbB signaling pathway_Homo sapiens_hsa040120.89817974
45Phenylalanine metabolism_Homo sapiens_hsa003600.88914163
46beta-Alanine metabolism_Homo sapiens_hsa004100.88896285
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87929125
48Fat digestion and absorption_Homo sapiens_hsa049750.81173123
49Renin secretion_Homo sapiens_hsa049240.80008425
50Fatty acid biosynthesis_Homo sapiens_hsa000610.78305993
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.78195247
52Salivary secretion_Homo sapiens_hsa049700.78166406
53Glutathione metabolism_Homo sapiens_hsa004800.76790432
54Bladder cancer_Homo sapiens_hsa052190.76774586
55MicroRNAs in cancer_Homo sapiens_hsa052060.75862183
56Mineral absorption_Homo sapiens_hsa049780.75278187
57Long-term potentiation_Homo sapiens_hsa047200.74405293
58Gastric acid secretion_Homo sapiens_hsa049710.73802020
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72928918
60Wnt signaling pathway_Homo sapiens_hsa043100.72616320
61Arginine biosynthesis_Homo sapiens_hsa002200.72113034
62Hepatitis C_Homo sapiens_hsa051600.71390064
63VEGF signaling pathway_Homo sapiens_hsa043700.69653699
64GnRH signaling pathway_Homo sapiens_hsa049120.69611914
65p53 signaling pathway_Homo sapiens_hsa041150.69310110
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.68833163
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67415599
68Glutamatergic synapse_Homo sapiens_hsa047240.65865745
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.65669593
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64284872
71Olfactory transduction_Homo sapiens_hsa047400.63840156
72ECM-receptor interaction_Homo sapiens_hsa045120.63424609
73Vibrio cholerae infection_Homo sapiens_hsa051100.63041275
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61977020
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61187528
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60254080
77Staphylococcus aureus infection_Homo sapiens_hsa051500.60059383
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57782776
79Inositol phosphate metabolism_Homo sapiens_hsa005620.57176989
80Amoebiasis_Homo sapiens_hsa051460.55485203
81Serotonergic synapse_Homo sapiens_hsa047260.55176163
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.54266885
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51727517
84Pancreatic secretion_Homo sapiens_hsa049720.51628520
85Nitrogen metabolism_Homo sapiens_hsa009100.51074751
86Amphetamine addiction_Homo sapiens_hsa050310.50867016
87MAPK signaling pathway_Homo sapiens_hsa040100.49635010
88Glucagon signaling pathway_Homo sapiens_hsa049220.49267526
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48959930
90Complement and coagulation cascades_Homo sapiens_hsa046100.47929736
91Pathways in cancer_Homo sapiens_hsa052000.47607078
92Endocytosis_Homo sapiens_hsa041440.47524881
93Glycerolipid metabolism_Homo sapiens_hsa005610.47127324
94Glioma_Homo sapiens_hsa052140.46810207
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.46393979
96Insulin signaling pathway_Homo sapiens_hsa049100.45985703
97Renin-angiotensin system_Homo sapiens_hsa046140.45937543
98Fatty acid degradation_Homo sapiens_hsa000710.44781618
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44243462
100Oxytocin signaling pathway_Homo sapiens_hsa049210.43985686
101cAMP signaling pathway_Homo sapiens_hsa040240.43368166
102Estrogen signaling pathway_Homo sapiens_hsa049150.43221863
103PPAR signaling pathway_Homo sapiens_hsa033200.41810077
104Platelet activation_Homo sapiens_hsa046110.41187115
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41018700
106Pertussis_Homo sapiens_hsa051330.40935486
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40853301
108Chemical carcinogenesis_Homo sapiens_hsa052040.40674130
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.40667257
110Circadian rhythm_Homo sapiens_hsa047100.39932037
111Fatty acid metabolism_Homo sapiens_hsa012120.39915103
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.38255522
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37538531
114Vitamin digestion and absorption_Homo sapiens_hsa049770.37271331
115Rheumatoid arthritis_Homo sapiens_hsa053230.37124748
116Tyrosine metabolism_Homo sapiens_hsa003500.35918453
117Dorso-ventral axis formation_Homo sapiens_hsa043200.35378223
118Prostate cancer_Homo sapiens_hsa052150.34688124
119T cell receptor signaling pathway_Homo sapiens_hsa046600.33851253
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33690525
121Lysosome_Homo sapiens_hsa041420.33190064
122Steroid biosynthesis_Homo sapiens_hsa001000.32754991
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32033337
124Thyroid cancer_Homo sapiens_hsa052160.31179328
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31167649
126Acute myeloid leukemia_Homo sapiens_hsa052210.31077923
127Circadian entrainment_Homo sapiens_hsa047130.28753547
128Renal cell carcinoma_Homo sapiens_hsa052110.28567529

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