SPINK13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1opioid receptor signaling pathway (GO:0038003)8.10063049
2negative regulation of cAMP-mediated signaling (GO:0043951)7.65071097
3pattern specification involved in kidney development (GO:0061004)7.59768779
4behavioral response to ethanol (GO:0048149)7.32655666
5adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)7.08894413
6ether lipid metabolic process (GO:0046485)6.79071211
7regulation of translational termination (GO:0006449)6.41338618
8drug transmembrane transport (GO:0006855)6.35599540
9adult feeding behavior (GO:0008343)6.26104792
10imidazole-containing compound metabolic process (GO:0052803)6.17689312
11response to pheromone (GO:0019236)5.89840833
12regulation of protein glycosylation (GO:0060049)5.77575552
13keratinocyte development (GO:0003334)5.71837220
14cellular response to electrical stimulus (GO:0071257)5.67136862
15regulation of keratinocyte proliferation (GO:0010837)5.32478677
16piRNA metabolic process (GO:0034587)4.83299980
17positive regulation of cAMP-mediated signaling (GO:0043950)4.69826751
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.64873073
19sphingosine metabolic process (GO:0006670)4.45935874
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.33681058
21regulation of glutamate receptor signaling pathway (GO:1900449)4.29043607
22mRNA cleavage (GO:0006379)4.28280064
23cellular response to ammonium ion (GO:0071242)4.26908110
24head development (GO:0060322)4.19503587
25diol metabolic process (GO:0034311)4.18459241
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.15704315
27positive regulation of synapse maturation (GO:0090129)4.10728311
28negative regulation of telomerase activity (GO:0051974)4.06993294
29dopamine biosynthetic process (GO:0042416)4.06396584
30presynaptic membrane organization (GO:0097090)4.04099318
31interferon-gamma production (GO:0032609)4.00185773
32cornea development in camera-type eye (GO:0061303)4.00171083
33sphingoid metabolic process (GO:0046519)3.93394486
34glomerular visceral epithelial cell development (GO:0072015)3.88903147
35regulation of activation of Janus kinase activity (GO:0010533)3.86521952
36notochord development (GO:0030903)3.86217673
37positive regulation of calcium ion import (GO:0090280)3.85111376
38pyrimidine nucleobase catabolic process (GO:0006208)3.83792101
39drug transport (GO:0015893)3.82339224
40proximal/distal pattern formation (GO:0009954)3.77683602
41telomere maintenance via telomerase (GO:0007004)3.77192410
42glycerol ether metabolic process (GO:0006662)3.75085643
43regulation of synapse maturation (GO:0090128)3.73957354
44dicarboxylic acid catabolic process (GO:0043649)3.70756232
45ncRNA catabolic process (GO:0034661)3.70653414
46auditory behavior (GO:0031223)3.67791818
47peripheral nervous system neuron development (GO:0048935)3.67080759
48coenzyme catabolic process (GO:0009109)3.66683568
49membrane depolarization during action potential (GO:0086010)3.65546373
50righting reflex (GO:0060013)3.62882375
51pyrimidine dimer repair (GO:0006290)3.62117833
52regulation of interleukin-5 production (GO:0032674)3.61636439
53DNA replication-dependent nucleosome organization (GO:0034723)3.61589355
54DNA replication-dependent nucleosome assembly (GO:0006335)3.61589355
55negative regulation of nitric oxide biosynthetic process (GO:0045019)3.59515890
56positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.59056957
57nucleobase catabolic process (GO:0046113)3.56845975
58regulation of megakaryocyte differentiation (GO:0045652)3.52214936
59synaptic transmission, glutamatergic (GO:0035249)3.50774519
60negative regulation of glycoprotein biosynthetic process (GO:0010561)3.48442741
61ether metabolic process (GO:0018904)3.44713685
62startle response (GO:0001964)3.43589943
63protein neddylation (GO:0045116)3.42310251
64gamma-aminobutyric acid transport (GO:0015812)3.38917905
65regulation of translational elongation (GO:0006448)3.35804252
66glomerular epithelial cell development (GO:0072310)3.35072541
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.32937333
68catechol-containing compound biosynthetic process (GO:0009713)3.31863560
69catecholamine biosynthetic process (GO:0042423)3.31863560
70cAMP catabolic process (GO:0006198)3.31734813
71neuronal action potential propagation (GO:0019227)3.29893818
72establishment of mitochondrion localization (GO:0051654)3.27413620
73replication fork processing (GO:0031297)3.24542701
74presynaptic membrane assembly (GO:0097105)3.24260738
75neuronal action potential (GO:0019228)3.22992755
76single strand break repair (GO:0000012)3.19369892
77cerebral cortex radially oriented cell migration (GO:0021799)3.18493288
78response to methylmercury (GO:0051597)3.13280308
79negative regulation of adenylate cyclase activity (GO:0007194)3.11173492
80regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09425633
81eyelid development in camera-type eye (GO:0061029)3.08244460
82amyloid precursor protein catabolic process (GO:0042987)3.07730186
83superoxide anion generation (GO:0042554)3.05424213
84proline transport (GO:0015824)3.05238343
85establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05131757
86mitochondrion transport along microtubule (GO:0047497)3.05131757
87regulation of cAMP-mediated signaling (GO:0043949)3.04552380
88mechanosensory behavior (GO:0007638)3.03114680
89positive regulation of cardiac muscle cell differentiation (GO:2000727)3.01418771
90acrosome reaction (GO:0007340)3.00557542
91thrombin receptor signaling pathway (GO:0070493)3.00013182
92regulation of cardiac muscle cell contraction (GO:0086004)2.99489922
93postsynaptic membrane organization (GO:0001941)2.98465436
94vocalization behavior (GO:0071625)2.97014946
95response to caffeine (GO:0031000)2.96538855
96positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.94420051
97negative regulation of cyclase activity (GO:0031280)2.93048940
98neuron-neuron synaptic transmission (GO:0007270)2.92316227
99glycosphingolipid metabolic process (GO:0006687)2.90995227
100ephrin receptor signaling pathway (GO:0048013)2.89498237
101negative regulation of lyase activity (GO:0051350)2.87812787
102cyclic nucleotide catabolic process (GO:0009214)2.86395214
103cellular ketone body metabolic process (GO:0046950)2.86043933
104atrial cardiac muscle cell action potential (GO:0086014)2.84469606
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83847448
106epithelial cilium movement (GO:0003351)2.83166839
107monoamine transport (GO:0015844)2.82440909
108regulation of calcium ion import (GO:0090279)2.82093251
109segment specification (GO:0007379)2.81408156
110regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.81030316
111lung epithelium development (GO:0060428)2.80951953
112protein localization to synapse (GO:0035418)2.80020276
113negative regulation of cAMP biosynthetic process (GO:0030818)2.79525090
114brain morphogenesis (GO:0048854)2.79259224
115eosinophil migration (GO:0072677)2.78650684
116positive regulation of receptor biosynthetic process (GO:0010870)2.78008155
117regulation of rhodopsin mediated signaling pathway (GO:0022400)2.77948936
118negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76762714
119detection of light stimulus involved in sensory perception (GO:0050962)2.75659471
120detection of light stimulus involved in visual perception (GO:0050908)2.75659471
121positive regulation of interleukin-4 production (GO:0032753)2.75429245
122metanephric nephron tubule development (GO:0072234)2.75319050
123metanephric tubule development (GO:0072170)2.75319050
124regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.72941306
125positive regulation of megakaryocyte differentiation (GO:0045654)2.71112741
126bile acid biosynthetic process (GO:0006699)2.70920524
127positive regulation of smooth muscle cell migration (GO:0014911)2.68173249
128sympathetic nervous system development (GO:0048485)2.68139176
129peptide catabolic process (GO:0043171)2.67499069
130negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.66920689
131DNA synthesis involved in DNA repair (GO:0000731)2.66653577
132detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.66311848
133negative regulation of interleukin-10 production (GO:0032693)2.65219149
134glycosphingolipid biosynthetic process (GO:0006688)2.65099585
135cellular response to alkaloid (GO:0071312)2.64797300
136neuron cell-cell adhesion (GO:0007158)2.60935853
137regulation of catecholamine metabolic process (GO:0042069)2.57885774
138regulation of dopamine metabolic process (GO:0042053)2.57885774
139regulation of telomerase activity (GO:0051972)2.54966246
140multicellular organism reproduction (GO:0032504)2.54474254
141hair follicle development (GO:0001942)2.54199948
142regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.53753695
143positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53408962
144central nervous system projection neuron axonogenesis (GO:0021952)2.53398225
145glycosylceramide metabolic process (GO:0006677)2.53058877
146response to auditory stimulus (GO:0010996)2.51172614
147negative regulation of nucleotide biosynthetic process (GO:0030809)2.51055414
148negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.51055414
149sperm motility (GO:0030317)2.50688939
150neutrophil activation (GO:0042119)2.50289699
151sensory perception of pain (GO:0019233)2.49552005
152neuron recognition (GO:0008038)2.49527719
153rhodopsin mediated signaling pathway (GO:0016056)2.49165441
154regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.49107381
155positive regulation of fibroblast migration (GO:0010763)2.48854013
156regulation of somitogenesis (GO:0014807)2.48523912
157RNA-dependent DNA replication (GO:0006278)2.48136079
158calcium ion import (GO:0070509)2.47727314
159neuronal ion channel clustering (GO:0045161)2.47609768
160retinal metabolic process (GO:0042574)2.47293777
161spermatid development (GO:0007286)2.47100358
162regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.46952198
163resolution of meiotic recombination intermediates (GO:0000712)2.46747152
164positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46533555
165phenol-containing compound catabolic process (GO:0019336)2.46510896
166ketone body metabolic process (GO:1902224)2.45856202
167negative regulation of cAMP metabolic process (GO:0030815)2.45826232
168cilium morphogenesis (GO:0060271)2.45770358
169meiotic chromosome segregation (GO:0045132)2.45679461
170cellular biogenic amine biosynthetic process (GO:0042401)2.45258077
171amine biosynthetic process (GO:0009309)2.45258077
172limb bud formation (GO:0060174)2.44690834
173positive regulation of antigen processing and presentation (GO:0002579)2.44158067
174skeletal muscle organ development (GO:0060538)2.43816162
175glycine transport (GO:0015816)2.43570685
176L-amino acid import (GO:0043092)2.42683824
177negative regulation of cell-matrix adhesion (GO:0001953)2.41937297
178focal adhesion assembly (GO:0048041)2.41854129
179cell-substrate adherens junction assembly (GO:0007045)2.41854129
180RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.41775835
181receptor recycling (GO:0001881)2.41497627
182response to epinephrine (GO:0071871)2.41393767
183androgen biosynthetic process (GO:0006702)2.41255721
184specification of organ identity (GO:0010092)2.39808079
185negative regulation of cell aging (GO:0090344)2.38750082
186myeloid dendritic cell differentiation (GO:0043011)2.38094697
187negative regulation of glycoprotein metabolic process (GO:1903019)2.37971450
188membrane lipid metabolic process (GO:0006643)2.36375757
189metanephric nephron epithelium development (GO:0072243)2.34205510
190layer formation in cerebral cortex (GO:0021819)2.33769640
191regulation of actin filament-based movement (GO:1903115)2.33708278
192synaptic vesicle exocytosis (GO:0016079)2.33321269
193negative regulation of osteoblast proliferation (GO:0033689)2.31773670
194positive regulation of granulocyte differentiation (GO:0030854)2.30004470
195negative regulation of cytosolic calcium ion concentration (GO:0051481)10.7546926
196negative regulation of keratinocyte proliferation (GO:0010839)10.6431428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IKZF1_21737484_ChIP-ChIP_HCT116_Human3.85714585
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.45716058
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21395411
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20127873
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91861537
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84701573
7GBX2_23144817_ChIP-Seq_PC3_Human2.70820393
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51185767
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45029480
10EZH2_22144423_ChIP-Seq_EOC_Human2.44405872
11RNF2_27304074_Chip-Seq_ESCs_Mouse2.38266020
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.36622021
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.35563273
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34853224
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.26846221
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24417333
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23454494
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22833220
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22833220
20IGF1R_20145208_ChIP-Seq_DFB_Human2.20448146
21POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.19988107
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19988107
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18804401
24VDR_22108803_ChIP-Seq_LS180_Human2.17613514
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09391599
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.07905915
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.07133017
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98487722
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98475273
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92860416
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92039902
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90995848
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83985799
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82318533
35AR_21572438_ChIP-Seq_LNCaP_Human1.79884275
36FUS_26573619_Chip-Seq_HEK293_Human1.79545175
37RXR_22108803_ChIP-Seq_LS180_Human1.79408493
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.77442189
39CBP_20019798_ChIP-Seq_JUKART_Human1.77442189
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.73692196
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72415072
42TP53_18474530_ChIP-ChIP_U2OS_Human1.70688831
43BCAT_22108803_ChIP-Seq_LS180_Human1.70421318
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70389264
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69176905
46* RNF2_27304074_Chip-Seq_NSC_Mouse1.68887905
47DROSHA_22980978_ChIP-Seq_HELA_Human1.66725376
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65809608
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65489396
50TAF15_26573619_Chip-Seq_HEK293_Human1.64340042
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61501815
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57957296
53AR_25329375_ChIP-Seq_VCAP_Human1.56552551
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56176296
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.55635289
56ER_23166858_ChIP-Seq_MCF-7_Human1.51543018
57NANOG_19829295_ChIP-Seq_ESCs_Human1.51373962
58SOX2_19829295_ChIP-Seq_ESCs_Human1.51373962
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.50562673
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50050234
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.49903029
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49654272
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.49099353
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49030247
65P53_22387025_ChIP-Seq_ESCs_Mouse1.48417025
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47566031
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.45156644
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.44000325
69EWS_26573619_Chip-Seq_HEK293_Human1.43946200
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.43170436
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41169143
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.41139387
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.40501043
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.40388838
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38468893
76ZNF274_21170338_ChIP-Seq_K562_Hela1.37627061
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36369102
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36102772
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.33887652
80ZFX_18555785_Chip-Seq_ESCs_Mouse1.33637147
81CTCF_18555785_Chip-Seq_ESCs_Mouse1.32847812
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32821210
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30739656
84TP53_22573176_ChIP-Seq_HFKS_Human1.30678803
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30576431
86P300_19829295_ChIP-Seq_ESCs_Human1.29699652
87TCF4_22108803_ChIP-Seq_LS180_Human1.29026672
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.28772008
89ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28713034
90SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28395465
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.27447054
92REST_21632747_ChIP-Seq_MESCs_Mouse1.27416539
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27015749
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26675520
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24211331
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23668886
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22830354
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22651174
99STAT3_23295773_ChIP-Seq_U87_Human1.22024516
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21930111
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.21542914
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21186968
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.19983444
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17656450
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16064797
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.14553164
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14381156
108CDX2_22108803_ChIP-Seq_LS180_Human1.14293418
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.13217673
110HTT_18923047_ChIP-ChIP_STHdh_Human1.12823626
111* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12447536
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12064875
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11815702
114P300_18555785_Chip-Seq_ESCs_Mouse1.10420360
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09716079
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.09694503
117RUNX2_22187159_ChIP-Seq_PCA_Human1.09122999
118TP53_20018659_ChIP-ChIP_R1E_Mouse1.08647452
119PU1_27457419_Chip-Seq_LIVER_Mouse1.08277472
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07813660
121TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07538891
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05853464
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05733333
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05469727
125* SOX9_26525672_Chip-Seq_HEART_Mouse1.05453422
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05057366
127SMAD4_21799915_ChIP-Seq_A2780_Human1.03143312
128AHR_22903824_ChIP-Seq_MCF-7_Human1.01550834
129JUN_21703547_ChIP-Seq_K562_Human1.01456921
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.01440003
131NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01107417
132NANOG_20526341_ChIP-Seq_ESCs_Human1.00855434
133* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00643460
134TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00233263
135TCF4_23295773_ChIP-Seq_U87_Human0.99928910
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.99502888
137TP53_16413492_ChIP-PET_HCT116_Human0.99010745
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.98736595
139KDM2B_26808549_Chip-Seq_REH_Human0.98310436
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98098421
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.98040173
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95862995
143REST_18959480_ChIP-ChIP_MESCs_Mouse0.95728625
144GATA3_21878914_ChIP-Seq_MCF-7_Human0.95609631
145SALL1_21062744_ChIP-ChIP_HESCs_Human0.95132116
146ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95099590
147OCT1_27270436_Chip-Seq_PROSTATE_Human0.93348588
148CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92949882
149* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92731677
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92300695
151MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.92051494
152FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91573591
153PRDM14_20953172_ChIP-Seq_ESCs_Human0.90937824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol5.86631574
2MP0005360_urolithiasis3.99227414
3MP0004510_myositis3.52126328
4MP0010234_abnormal_vibrissa_follicle3.39949687
5MP0003283_abnormal_digestive_organ3.35379336
6MP0003183_abnormal_peptide_metabolism3.22286164
7MP0006292_abnormal_olfactory_placode3.21561759
8MP0004885_abnormal_endolymph2.99584278
9MP0004859_abnormal_synaptic_plasticity2.92092609
10MP0002876_abnormal_thyroid_physiology2.76601391
11MP0003011_delayed_dark_adaptation2.74800618
12MP0005451_abnormal_body_composition2.73193346
13MP0009278_abnormal_bone_marrow2.71154244
14MP0002735_abnormal_chemical_nociception2.56314450
15MP0001501_abnormal_sleep_pattern2.40974597
16MP0004142_abnormal_muscle_tone2.35071053
17MP0004270_analgesia2.21357541
18MP0005085_abnormal_gallbladder_physiolo2.19657125
19MP0000579_abnormal_nail_morphology2.13049724
20MP0003635_abnormal_synaptic_transmissio2.07100906
21MP0000569_abnormal_digit_pigmentation2.03203399
22MP0005171_absent_coat_pigmentation2.02157637
23MP0003880_abnormal_central_pattern1.94658702
24MP0004133_heterotaxia1.90675613
25MP0009053_abnormal_anal_canal1.80174930
26MP0003195_calcinosis1.77168640
27MP0008057_abnormal_DNA_replication1.77079997
28MP0000003_abnormal_adipose_tissue1.76845757
29MP0006035_abnormal_mitochondrial_morpho1.75314254
30MP0001188_hyperpigmentation1.72523664
31MP0001177_atelectasis1.68571440
32MP0004147_increased_porphyrin_level1.64843914
33MP0004145_abnormal_muscle_electrophysio1.60553804
34MP0009745_abnormal_behavioral_response1.60331959
35MP0009046_muscle_twitch1.59049278
36MP0002272_abnormal_nervous_system1.57015681
37MP0001919_abnormal_reproductive_system1.56137567
38MP0006072_abnormal_retinal_apoptosis1.51269447
39MP0002163_abnormal_gland_morphology1.51227604
40MP0005503_abnormal_tendon_morphology1.50519316
41MP0003879_abnormal_hair_cell1.49340795
42MP0008058_abnormal_DNA_repair1.47794563
43MP0003938_abnormal_ear_development1.47209001
44MP0000681_abnormal_thyroid_gland1.47121127
45MP0000778_abnormal_nervous_system1.45825420
46MP0001905_abnormal_dopamine_level1.45486154
47MP0001664_abnormal_digestion1.44879222
48MP0002249_abnormal_larynx_morphology1.44868856
49MP0003633_abnormal_nervous_system1.44488505
50MP0002734_abnormal_mechanical_nocicepti1.43516982
51MP0003868_abnormal_feces_composition1.42261782
52MP0000631_abnormal_neuroendocrine_gland1.41166264
53MP0010368_abnormal_lymphatic_system1.41085541
54MP0002184_abnormal_innervation1.40544098
55MP0008875_abnormal_xenobiotic_pharmacok1.37901274
56MP0001440_abnormal_grooming_behavior1.36446185
57MP0002063_abnormal_learning/memory/cond1.35430322
58MP0004134_abnormal_chest_morphology1.34094412
59MP0010678_abnormal_skin_adnexa1.31330435
60MP0001764_abnormal_homeostasis1.30747598
61MP0002557_abnormal_social/conspecific_i1.30648288
62MP0000427_abnormal_hair_cycle1.30542702
63MP0002295_abnormal_pulmonary_circulatio1.29302576
64MP0005379_endocrine/exocrine_gland_phen1.28440573
65MP0001486_abnormal_startle_reflex1.28097218
66MP0002160_abnormal_reproductive_system1.27384048
67MP0002102_abnormal_ear_morphology1.23451197
68MP0005253_abnormal_eye_physiology1.21800846
69MP0003787_abnormal_imprinting1.21068088
70MP0002572_abnormal_emotion/affect_behav1.19032988
71MP0005551_abnormal_eye_electrophysiolog1.16427310
72MP0001970_abnormal_pain_threshold1.15969839
73MP0002233_abnormal_nose_morphology1.15938980
74MP0002064_seizures1.15804420
75MP0003045_fibrosis1.14618769
76MP0003123_paternal_imprinting1.14287136
77MP0003941_abnormal_skin_development1.13097104
78MP0008789_abnormal_olfactory_epithelium1.12765432
79MP0004924_abnormal_behavior1.11744206
80MP0005386_behavior/neurological_phenoty1.11744206
81MP0001984_abnormal_olfaction1.11476799
82MP0005423_abnormal_somatic_nervous1.10408353
83MP0005195_abnormal_posterior_eye1.10202455
84MP0008775_abnormal_heart_ventricle1.09781777
85MP0005623_abnormal_meninges_morphology1.09149912
86MP0000955_abnormal_spinal_cord1.06748048
87MP0002067_abnormal_sensory_capabilities1.05366150
88MP0009780_abnormal_chondrocyte_physiolo1.05074168
89MP0003950_abnormal_plasma_membrane1.04820349
90MP0002229_neurodegeneration1.04726770
91MP0005248_abnormal_Harderian_gland1.02748079
92MP0005410_abnormal_fertilization1.02655476
93MP0000920_abnormal_myelination1.02343560
94MP0002733_abnormal_thermal_nociception1.01222070
95MP0003631_nervous_system_phenotype1.00717574
96MP0002697_abnormal_eye_size0.98972491
97MP0003385_abnormal_body_wall0.98972261
98MP0003937_abnormal_limbs/digits/tail_de0.98845581
99MP0000762_abnormal_tongue_morphology0.98714772
100MP0001270_distended_abdomen0.98259948
101MP0010386_abnormal_urinary_bladder0.96046147
102MP0001968_abnormal_touch/_nociception0.95952849
103MP0005499_abnormal_olfactory_system0.94505866
104MP0005394_taste/olfaction_phenotype0.94505866
105MP0002736_abnormal_nociception_after0.94090024
106MP0005389_reproductive_system_phenotype0.93932480
107MP0002638_abnormal_pupillary_reflex0.92611431
108MP0006276_abnormal_autonomic_nervous0.92388306
109MP0000015_abnormal_ear_pigmentation0.92000156
110MP0002837_dystrophic_cardiac_calcinosis0.91185214
111MP0000049_abnormal_middle_ear0.88931709
112MP0000537_abnormal_urethra_morphology0.88405498
113MP0004043_abnormal_pH_regulation0.88387317
114MP0008872_abnormal_physiological_respon0.87466704
115MP0004811_abnormal_neuron_physiology0.87390019
116MP0000749_muscle_degeneration0.86825961
117MP0003646_muscle_fatigue0.86541875
118MP0001293_anophthalmia0.84727372
119MP0000013_abnormal_adipose_tissue0.84671885
120MP0009764_decreased_sensitivity_to0.84589336
121MP0000026_abnormal_inner_ear0.83840595
122MP0008874_decreased_physiological_sensi0.83503247
123MP0000678_abnormal_parathyroid_gland0.83481289
124MP0000358_abnormal_cell_content/0.82670820
125MP0002752_abnormal_somatic_nervous0.81081701
126MP0009250_abnormal_appendicular_skeleto0.81022629
127MP0001529_abnormal_vocalization0.80968950
128MP0002882_abnormal_neuron_morphology0.80631972
129MP0001324_abnormal_eye_pigmentation0.80446417
130MP0005646_abnormal_pituitary_gland0.79225635
131MP0003698_abnormal_male_reproductive0.77683325
132MP0008877_abnormal_DNA_methylation0.77494253
133MP0002066_abnormal_motor_capabilities/c0.76403374
134MP0006138_congestive_heart_failure0.76299540
135MP0002971_abnormal_brown_adipose0.76041212
136MP0008260_abnormal_autophagy0.75843513
137MP0004085_abnormal_heartbeat0.74149280
138MP0002254_reproductive_system_inflammat0.73966274
139MP0002234_abnormal_pharynx_morphology0.73370726
140MP0004233_abnormal_muscle_weight0.73169539
141MP0000639_abnormal_adrenal_gland0.70103500
142MP0003718_maternal_effect0.69913436
143MP0003252_abnormal_bile_duct0.69157114
144MP0001963_abnormal_hearing_physiology0.69125504
145MP0005391_vision/eye_phenotype0.68986155
146MP0002090_abnormal_vision0.68597719
147MP0001986_abnormal_taste_sensitivity0.68262599
148MP0002282_abnormal_trachea_morphology0.68235609
149MP0001340_abnormal_eyelid_morphology0.67993634
150MP0003959_abnormal_lean_body0.66084269
151MP0010771_integument_phenotype0.64982732
152MP0003567_abnormal_fetal_cardiomyocyte0.64766516
153MP0002928_abnormal_bile_duct0.63518008

Predicted human phenotypes

RankGene SetZ-score
1Prolonged neonatal jaundice (HP:0006579)6.83125511
2Intrahepatic cholestasis (HP:0001406)5.73984037
3Volvulus (HP:0002580)5.72378314
4Broad alveolar ridges (HP:0000187)5.14526072
5Intestinal atresia (HP:0011100)4.62970812
6Gastrointestinal stroma tumor (HP:0100723)4.58346428
7Decreased central vision (HP:0007663)4.46960598
8Absent speech (HP:0001344)4.33810286
9Optic nerve hypoplasia (HP:0000609)4.29106893
10Pancreatic islet-cell hyperplasia (HP:0004510)3.97713988
11Cerebellar dysplasia (HP:0007033)3.95869572
12Type II lissencephaly (HP:0007260)3.93925170
13Gaze-evoked nystagmus (HP:0000640)3.86666737
14Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.58069875
15Lissencephaly (HP:0001339)3.57585755
16Upper limb muscle weakness (HP:0003484)3.47609246
17Aplasia cutis congenita (HP:0001057)3.41538250
18Metabolic alkalosis (HP:0200114)3.41269933
19Tented upper lip vermilion (HP:0010804)3.39212530
20Thickened helices (HP:0000391)3.30286036
21Oligodontia (HP:0000677)3.27999248
22Retinal dysplasia (HP:0007973)3.24732623
23Large for gestational age (HP:0001520)3.23170254
24Hypokalemic alkalosis (HP:0001949)3.18802031
25Amyloidosis (HP:0011034)3.17897326
26Progressive inability to walk (HP:0002505)3.13545652
27Tubular atrophy (HP:0000092)3.13434503
28Abnormality of the ileum (HP:0001549)3.13190853
29Confusion (HP:0001289)3.13177775
30Focal seizures (HP:0007359)3.11807807
31Status epilepticus (HP:0002133)2.98655552
32Agitation (HP:0000713)2.96861091
33Abnormality of the pancreatic islet cells (HP:0006476)2.95821722
34Abnormality of endocrine pancreas physiology (HP:0012093)2.95821722
35Broad-based gait (HP:0002136)2.94139087
36Increased corneal curvature (HP:0100692)2.92524869
37Keratoconus (HP:0000563)2.92524869
383-Methylglutaconic aciduria (HP:0003535)2.90326157
39Abnormality of macular pigmentation (HP:0008002)2.88186293
40Fat malabsorption (HP:0002630)2.88112395
41Abnormal hair laboratory examination (HP:0003328)2.85030977
42Pendular nystagmus (HP:0012043)2.84489352
43Septo-optic dysplasia (HP:0100842)2.82847541
44Poor head control (HP:0002421)2.80612177
45Neonatal respiratory distress (HP:0002643)2.79250361
46Abnormality of the pulmonary veins (HP:0011718)2.78923850
47Focal motor seizures (HP:0011153)2.78158915
48Chorioretinal coloboma (HP:0000567)2.75102374
49Congenital stationary night blindness (HP:0007642)2.73652037
50Anomalous pulmonary venous return (HP:0010772)2.72601384
51Inability to walk (HP:0002540)2.70800317
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.70600238
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.69257675
54Sensorimotor neuropathy (HP:0007141)2.67458472
55Hyperventilation (HP:0002883)2.64766470
56Mesangial abnormality (HP:0001966)2.62069974
57White forelock (HP:0002211)2.57914622
58Pili torti (HP:0003777)2.56144255
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53897774
60Gastrointestinal atresia (HP:0002589)2.52049003
61Cutaneous melanoma (HP:0012056)2.50826377
62Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.50486490
63Chromsome breakage (HP:0040012)2.49393820
64Horizontal nystagmus (HP:0000666)2.48015956
65Broad nasal tip (HP:0000455)2.45172689
66Dialeptic seizures (HP:0011146)2.43818574
67Abnormality of the renal cortex (HP:0011035)2.43391809
68Hyperglycinuria (HP:0003108)2.38939344
69Large eyes (HP:0001090)2.38128430
70Thyroid-stimulating hormone excess (HP:0002925)2.35832828
71Restrictive lung disease (HP:0002091)2.32598237
72Onion bulb formation (HP:0003383)2.31746599
73Fragile nails (HP:0001808)2.31014920
74Nasolacrimal duct obstruction (HP:0000579)2.25102891
75Abnormality of liposaccharide metabolism (HP:0010968)2.24008963
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.24008963
77Abnormality of glycolipid metabolism (HP:0010969)2.24008963
78Carpal bone hypoplasia (HP:0001498)2.23734473
79Emphysema (HP:0002097)2.23690574
80Lower limb amyotrophy (HP:0007210)2.23186915
81Pheochromocytoma (HP:0002666)2.22976046
82Intellectual disability, moderate (HP:0002342)2.21379611
83Ketoacidosis (HP:0001993)2.20815213
84Partial duplication of thumb phalanx (HP:0009944)2.19547168
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19077978
86Pachygyria (HP:0001302)2.18514005
87Astrocytoma (HP:0009592)2.17199214
88Abnormality of the astrocytes (HP:0100707)2.17199214
89Abnormality of the alveolar ridges (HP:0006477)2.15108256
90Abnormality of serine family amino acid metabolism (HP:0010894)2.14473049
91Abnormality of glycine metabolism (HP:0010895)2.14473049
92Mesomelia (HP:0003027)2.13467262
93Patchy hypopigmentation of hair (HP:0011365)2.13132421
94Pancreatic cysts (HP:0001737)2.12701243
95Curly hair (HP:0002212)2.12218434
96Broad metatarsal (HP:0001783)2.11937121
97Morphological abnormality of the middle ear (HP:0008609)2.11780788
98Hip dysplasia (HP:0001385)2.10813029
99Attenuation of retinal blood vessels (HP:0007843)2.09274569
100Hyperpituitarism (HP:0010514)2.07518317
101Aplasia involving bones of the upper limbs (HP:0009823)2.07116948
102Aplasia of the phalanges of the hand (HP:0009802)2.07116948
103Aplasia involving bones of the extremities (HP:0009825)2.07116948
104Severe muscular hypotonia (HP:0006829)2.06206497
105Synostosis of carpal bones (HP:0005048)2.05817786
106J-shaped sella turcica (HP:0002680)2.03365787
107Abnormality of the phalanges of the hallux (HP:0010057)2.02497802
108Anophthalmia (HP:0000528)2.01958440
109Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01628427
110Fair hair (HP:0002286)2.00414504
111Severe visual impairment (HP:0001141)2.00322987
112Abnormality of the fovea (HP:0000493)1.99509290
113Myokymia (HP:0002411)1.96680820
114Partial duplication of the phalanx of hand (HP:0009999)1.96255465
115Renal cortical cysts (HP:0000803)1.94256199
116Generalized hypotonia (HP:0001290)1.94110497
117Prostate neoplasm (HP:0100787)1.93899158
118Visual hallucinations (HP:0002367)1.92644591
119Neuroendocrine neoplasm (HP:0100634)1.89464627
120Broad ribs (HP:0000885)1.89458660
121Truncus arteriosus (HP:0001660)1.88161087
122Poikiloderma (HP:0001029)1.88136756
123Pulmonary artery stenosis (HP:0004415)1.88080537
124Ankyloglossia (HP:0010296)1.88062934
125Cortical dysplasia (HP:0002539)1.87806983
126Abnormality of the aortic arch (HP:0012303)1.87370519
127Fatigue (HP:0012378)1.87283492
128Insomnia (HP:0100785)1.86877359
129Absent septum pellucidum (HP:0001331)1.85867432
130Pancreatic fibrosis (HP:0100732)1.85288838
131Ulnar deviation of finger (HP:0009465)1.84939193
132Bony spicule pigmentary retinopathy (HP:0007737)1.82500351
133Lymphopenia (HP:0001888)1.81914605
134Prolonged QT interval (HP:0001657)1.80786416
135Supranuclear gaze palsy (HP:0000605)1.80720082
136Midline defect of the nose (HP:0004122)1.79982503
137Generalized tonic-clonic seizures (HP:0002069)1.79472188
138Wrist flexion contracture (HP:0001239)1.78846751
139Meningocele (HP:0002435)1.78621882
140Fetal akinesia sequence (HP:0001989)1.78473792
141EEG with generalized epileptiform discharges (HP:0011198)1.76877209
142Abnormal rod and cone electroretinograms (HP:0008323)1.76449030
143Lip pit (HP:0100267)1.75288411
144Encephalitis (HP:0002383)1.74187561
145Narrow nasal bridge (HP:0000446)1.73869620
146Congenital ichthyosiform erythroderma (HP:0007431)1.73755781
147Atonic seizures (HP:0010819)1.73360659
148Abnormality of the vitreous humor (HP:0004327)1.72901659
149Syncope (HP:0001279)1.72295175
150Reticulocytosis (HP:0001923)1.72176039
151Prolonged bleeding time (HP:0003010)1.71774820
152High anterior hairline (HP:0009890)1.71107408
153Epileptic encephalopathy (HP:0200134)1.70712883
154Epileptiform EEG discharges (HP:0011182)1.69256550
155Bradycardia (HP:0001662)1.68698014
156Dysdiadochokinesis (HP:0002075)1.68660447
157Amblyopia (HP:0000646)1.67180071
158Abnormality of cells of the lymphoid lineage (HP:0012140)1.67169811
159Anterior segment dysgenesis (HP:0007700)1.66557258
160True hermaphroditism (HP:0010459)1.65481154
161Glioma (HP:0009733)1.64953973
162Chronic mucocutaneous candidiasis (HP:0002728)1.64123609
163Recurrent cutaneous fungal infections (HP:0011370)1.64123609
164Methylmalonic aciduria (HP:0012120)1.64001072
165Aplasia/Hypoplasia of the brainstem (HP:0007362)1.63907458
166Hypoplasia of the brainstem (HP:0002365)1.63907458
167Febrile seizures (HP:0002373)1.63816765
168Hypoplasia of the pons (HP:0012110)1.59899094
169Drooling (HP:0002307)1.59273403
170Hypoalbuminemia (HP:0003073)1.58361879
171Abnormal albumin level (HP:0012116)1.58361879
172Oligodactyly (hands) (HP:0001180)1.57660753
173Ketosis (HP:0001946)1.57500204
174Nephroblastoma (Wilms tumor) (HP:0002667)1.56659405
175Hypoproteinemia (HP:0003075)1.55950071
176Meningioma (HP:0002858)1.55384483
177Poor speech (HP:0002465)1.55061626
178Truncal ataxia (HP:0002078)1.54873648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.74177587
2STK38L4.89527495
3STK244.73902629
4PINK13.98199513
5PNCK3.00047136
6BMPR1B2.87898967
7CDK122.65326527
8DYRK32.23624226
9EPHB22.22719878
10CAMKK22.17577780
11MARK12.15071453
12CASK11.3424843
13PIK3CG1.88191596
14INSRR1.79992868
15TYRO31.79027049
16IRAK31.74301088
17LATS11.70747818
18CSNK1G31.70009550
19STK161.68755885
20PDK21.63007731
21TGFBR11.61029453
22NTRK31.55111927
23ACVR1B1.53095223
24SRPK11.52552944
25PRKD21.52295207
26PRKCG1.51402607
27CSNK1A1L1.49122372
28EIF2AK21.44570717
29ADRBK21.43352092
30CSNK1G11.38285983
31PRKCE1.38258100
32PKN11.30191142
33CSNK1G21.28156883
34MAP4K21.27446796
35CAMK1G1.18771041
36EIF2AK31.18549086
37ERN11.17697080
38ZAK1.13362122
39WNK31.10288858
40CCNB11.09099242
41GRK51.07964090
42STK31.04677336
43STK111.03657142
44MAPK131.02919652
45DYRK20.97617713
46MST1R0.96748948
47CAMK10.91107043
48ERBB40.87353810
49PRKCH0.85782931
50FGR0.85154397
51RET0.82922645
52MKNK10.82007363
53TRIM280.81784569
54CLK10.81644495
55PIM10.81248296
56MINK10.80766369
57DMPK0.80453305
58MUSK0.79170541
59STK390.75525871
60IRAK10.74848775
61PRPF4B0.73959059
62BCR0.73801442
63MKNK20.73491862
64BRSK10.72833204
65MAP2K70.71557194
66CDC42BPA0.71050047
67CDK50.69783504
68STK380.69376808
69PRKCI0.69302268
70DYRK1A0.68438889
71GRK70.68061671
72MAP3K60.67567702
73NEK20.67339763
74STK100.67334520
75MAP2K60.65604579
76OXSR10.63327541
77WEE10.62413793
78MAPKAPK50.61963732
79WNK40.60992010
80PAK60.60637082
81SIK20.59277473
82CAMK2A0.58396592
83PHKG10.57850303
84PHKG20.57850303
85MYLK0.56349872
86ATM0.56209226
87TSSK60.54634833
88NUAK10.54131724
89MAPK110.50983725
90CSNK1E0.50520715
91EPHA40.49223856
92TNIK0.48305361
93PTK20.47706178
94TGFBR20.47326576
95FER0.45307843
96MOS0.45013505
97BRAF0.44695786
98YES10.42776051
99MAP3K70.42543890
100PRKG10.41654952
101BRSK20.41452490
102MST40.41076044
103PTK2B0.40649052
104MAP3K40.40518871
105TLK10.39735104
106FGFR20.39712430
107PRKAA20.39358147
108NEK90.39167670
109PKN20.38713078
110PRKCB0.38360043
111TXK0.37852611
112RPS6KA50.37639301
113CAMKK10.37619562
114NTRK20.37145150
115LATS20.36438075
116KIT0.36193057
117RPS6KA30.35805632
118CDK40.35590690
119MET0.35431997
120CAMK2B0.35197959
121PRKAA10.34180548
122MAPK40.34007523
123PRKACA0.32882171
124PLK20.31690609
125MARK30.31472030
126PAK30.31229115
127MAP2K40.30373813
128ERBB20.30364937
129PRKCA0.30020633
130CAMK40.29711026
131SIK30.29513861
132PRKDC0.29381495
133TTK0.29155153
134PRKCQ0.28200237
135MAP3K140.27748063
136FLT30.27529278
137ADRBK10.27034144
138UHMK10.26730254
139CAMK2D0.25612587
140OBSCN0.25538747
141MELK0.25168386
142CSNK1D0.24821135
143PRKD30.24653954
144IKBKE0.24253088
145IKBKB0.24200576
146FES0.24121587
147KSR10.23421655
148PRKACB0.21696929
149CDK30.20602393
150GRK10.20490081
151ABL10.20331344
152PLK10.19974410
153SRC0.19903961
154MAP3K130.19312340
155GRK60.18982789
156WNK10.18923020
157CAMK2G0.18349984
158CSNK1A10.18005840
159DAPK20.17065274

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39629507
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28998579
3Cocaine addiction_Homo sapiens_hsa050302.71485636
4Steroid biosynthesis_Homo sapiens_hsa001002.65803960
5Nicotine addiction_Homo sapiens_hsa050332.56872055
6Morphine addiction_Homo sapiens_hsa050322.41774915
7Butanoate metabolism_Homo sapiens_hsa006502.08571674
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.05541574
9Synaptic vesicle cycle_Homo sapiens_hsa047211.95634951
10Axon guidance_Homo sapiens_hsa043601.90585648
11Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.87180742
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86584033
13Glutamatergic synapse_Homo sapiens_hsa047241.83054912
14Fanconi anemia pathway_Homo sapiens_hsa034601.81912064
15Taste transduction_Homo sapiens_hsa047421.81005520
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78786006
17Sphingolipid metabolism_Homo sapiens_hsa006001.75272429
18Amphetamine addiction_Homo sapiens_hsa050311.70971001
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70282616
20Olfactory transduction_Homo sapiens_hsa047401.65356616
21Histidine metabolism_Homo sapiens_hsa003401.60443988
22Serotonergic synapse_Homo sapiens_hsa047261.58291590
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54672745
24Arginine biosynthesis_Homo sapiens_hsa002201.52910363
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47481649
26GABAergic synapse_Homo sapiens_hsa047271.43532671
27Nitrogen metabolism_Homo sapiens_hsa009101.43166556
28Salivary secretion_Homo sapiens_hsa049701.38223298
29Renin secretion_Homo sapiens_hsa049241.36483687
30Phototransduction_Homo sapiens_hsa047441.34313837
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32892402
32ABC transporters_Homo sapiens_hsa020101.30527339
33Dopaminergic synapse_Homo sapiens_hsa047281.21821966
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19870293
35Cholinergic synapse_Homo sapiens_hsa047251.19846276
36Circadian entrainment_Homo sapiens_hsa047131.16744225
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15079320
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14980220
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14521737
40Dilated cardiomyopathy_Homo sapiens_hsa054141.13762048
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.11803413
42Ovarian steroidogenesis_Homo sapiens_hsa049131.11763934
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11614353
44Calcium signaling pathway_Homo sapiens_hsa040201.10503490
45Inositol phosphate metabolism_Homo sapiens_hsa005621.09729072
46Insulin secretion_Homo sapiens_hsa049111.09386635
47Tryptophan metabolism_Homo sapiens_hsa003801.07392450
48Protein export_Homo sapiens_hsa030601.04170760
49Retinol metabolism_Homo sapiens_hsa008300.99587721
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97703329
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.96253902
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95189764
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94085108
54Asthma_Homo sapiens_hsa053100.93857111
55Basal cell carcinoma_Homo sapiens_hsa052170.93671453
56Glycerolipid metabolism_Homo sapiens_hsa005610.93126308
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91118119
58Oxytocin signaling pathway_Homo sapiens_hsa049210.91011433
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89320765
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88240911
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87182534
62Mineral absorption_Homo sapiens_hsa049780.86627600
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.86434534
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86295503
65cAMP signaling pathway_Homo sapiens_hsa040240.85983901
66Pentose phosphate pathway_Homo sapiens_hsa000300.85341231
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84739969
68Peroxisome_Homo sapiens_hsa041460.83401221
69Gastric acid secretion_Homo sapiens_hsa049710.83148248
70Glutathione metabolism_Homo sapiens_hsa004800.82474440
71Linoleic acid metabolism_Homo sapiens_hsa005910.81393345
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80762458
73RNA degradation_Homo sapiens_hsa030180.80428259
74Chemokine signaling pathway_Homo sapiens_hsa040620.79965478
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79456895
76Hedgehog signaling pathway_Homo sapiens_hsa043400.79004336
77Sulfur relay system_Homo sapiens_hsa041220.78581184
78Fatty acid elongation_Homo sapiens_hsa000620.77759732
79Propanoate metabolism_Homo sapiens_hsa006400.77004984
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76523363
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76062114
82Selenocompound metabolism_Homo sapiens_hsa004500.75765030
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74603912
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74049061
85Wnt signaling pathway_Homo sapiens_hsa043100.71650300
86Cardiac muscle contraction_Homo sapiens_hsa042600.71441911
87Fatty acid metabolism_Homo sapiens_hsa012120.70554700
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69281986
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67284805
90Alcoholism_Homo sapiens_hsa050340.67032112
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.67031392
92Chemical carcinogenesis_Homo sapiens_hsa052040.66735094
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66303249
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65565776
95Collecting duct acid secretion_Homo sapiens_hsa049660.65328511
96Circadian rhythm_Homo sapiens_hsa047100.65299948
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.64440327
98Melanogenesis_Homo sapiens_hsa049160.62842244
99ErbB signaling pathway_Homo sapiens_hsa040120.61996209
100Arachidonic acid metabolism_Homo sapiens_hsa005900.61739960
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61546483
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61495407
103Arginine and proline metabolism_Homo sapiens_hsa003300.60606529
104Metabolic pathways_Homo sapiens_hsa011000.59873517
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.58521116
106Ras signaling pathway_Homo sapiens_hsa040140.57896074
107Ether lipid metabolism_Homo sapiens_hsa005650.56099986
108Pathways in cancer_Homo sapiens_hsa052000.55662604
109Choline metabolism in cancer_Homo sapiens_hsa052310.52826430
110Basal transcription factors_Homo sapiens_hsa030220.52824715
111Estrogen signaling pathway_Homo sapiens_hsa049150.52818060
112Vitamin B6 metabolism_Homo sapiens_hsa007500.51686560
113Pancreatic cancer_Homo sapiens_hsa052120.49212067
114Starch and sucrose metabolism_Homo sapiens_hsa005000.47374781
115Tyrosine metabolism_Homo sapiens_hsa003500.47066550
116Dorso-ventral axis formation_Homo sapiens_hsa043200.46729119
117Oocyte meiosis_Homo sapiens_hsa041140.46712139
118MAPK signaling pathway_Homo sapiens_hsa040100.46673708
119Long-term depression_Homo sapiens_hsa047300.46447899
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45632541
121Endocytosis_Homo sapiens_hsa041440.44922678
122Fatty acid degradation_Homo sapiens_hsa000710.43467466
123Phenylalanine metabolism_Homo sapiens_hsa003600.42415861
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42376818
125Homologous recombination_Homo sapiens_hsa034400.42311489
126Purine metabolism_Homo sapiens_hsa002300.42127002
127Caffeine metabolism_Homo sapiens_hsa002320.41441538
128Hematopoietic cell lineage_Homo sapiens_hsa046400.40884561
129Sulfur metabolism_Homo sapiens_hsa009200.40810638
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.40504261
131Bile secretion_Homo sapiens_hsa049760.39500866
132Thyroid hormone synthesis_Homo sapiens_hsa049180.39372021
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39337094
134mRNA surveillance pathway_Homo sapiens_hsa030150.38970962
135beta-Alanine metabolism_Homo sapiens_hsa004100.38029776
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37501627
137Gap junction_Homo sapiens_hsa045400.37066429
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.36373503
139Regulation of autophagy_Homo sapiens_hsa041400.35552911
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35406033

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