SPIDR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of bacterium (GO:0016045)6.20344260
2regulation of dendritic cell antigen processing and presentation (GO:0002604)5.86572572
3detection of other organism (GO:0098543)5.69902344
4cilium or flagellum-dependent cell motility (GO:0001539)5.24255201
5ventricular system development (GO:0021591)5.13474480
6positive regulation of antigen processing and presentation (GO:0002579)4.72777805
7protein localization to kinetochore (GO:0034501)4.38700039
8DNA unwinding involved in DNA replication (GO:0006268)4.29974239
9DNA replication initiation (GO:0006270)4.27458601
10embryonic process involved in female pregnancy (GO:0060136)4.19558356
11DNA strand elongation (GO:0022616)4.05037168
12mitotic sister chromatid cohesion (GO:0007064)4.04084376
13positive regulation of gamma-delta T cell activation (GO:0046645)4.03999191
14negative regulation of interleukin-8 production (GO:0032717)4.03299468
15DNA strand elongation involved in DNA replication (GO:0006271)3.96836122
16peptidyl-lysine dimethylation (GO:0018027)3.94268129
17regulation of antigen processing and presentation (GO:0002577)3.90764582
18telomere maintenance via semi-conservative replication (GO:0032201)3.87636952
19axonemal dynein complex assembly (GO:0070286)3.87606791
20protein localization to chromosome, centromeric region (GO:0071459)3.83310252
21mitotic nuclear envelope disassembly (GO:0007077)3.80854027
22RNA localization (GO:0006403)3.80839721
23positive regulation of B cell differentiation (GO:0045579)3.78333814
24stress granule assembly (GO:0034063)3.77129153
25attachment of spindle microtubules to kinetochore (GO:0008608)3.68965694
26CENP-A containing nucleosome assembly (GO:0034080)3.67259237
27telomere maintenance via recombination (GO:0000722)3.67093747
28peptidyl-lysine trimethylation (GO:0018023)3.66594029
29negative regulation of interleukin-1 beta production (GO:0032691)3.65475925
30protein localization to cilium (GO:0061512)3.65007641
31histone H3-K9 methylation (GO:0051567)3.61684705
32chromatin remodeling at centromere (GO:0031055)3.61087078
33left/right axis specification (GO:0070986)3.59115858
34motile cilium assembly (GO:0044458)3.56083969
35mitotic metaphase plate congression (GO:0007080)3.55453394
36germ cell migration (GO:0008354)3.54320339
37mitotic recombination (GO:0006312)3.52746733
38establishment of protein localization to Golgi (GO:0072600)3.49015763
39granulocyte differentiation (GO:0030851)3.48902721
40regulation of gamma-delta T cell differentiation (GO:0045586)3.48361331
41regulation of cellular extravasation (GO:0002691)3.47905477
42kinetochore organization (GO:0051383)3.47552422
43membrane disassembly (GO:0030397)3.46428514
44nuclear envelope disassembly (GO:0051081)3.46428514
45megakaryocyte development (GO:0035855)3.46087070
46negative regulation of erythrocyte differentiation (GO:0045647)3.45594201
47interkinetic nuclear migration (GO:0022027)3.45414468
48prenylation (GO:0097354)3.44769779
49protein prenylation (GO:0018342)3.44769779
50sphingomyelin metabolic process (GO:0006684)3.43879334
51cell wall macromolecule catabolic process (GO:0016998)3.42621686
52nuclear pore organization (GO:0006999)3.40598064
53mitotic chromosome condensation (GO:0007076)3.40510225
54positive regulation of mRNA catabolic process (GO:0061014)3.38980331
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33546591
56retrograde transport, vesicle recycling within Golgi (GO:0000301)3.31559176
57telomere maintenance via telomere lengthening (GO:0010833)3.30873111
58negative regulation of interleukin-1 production (GO:0032692)3.30308038
59dosage compensation (GO:0007549)3.30295939
60N-terminal protein amino acid acetylation (GO:0006474)3.27808294
61nuclear pore complex assembly (GO:0051292)3.26747392
62ribosomal small subunit assembly (GO:0000028)3.25638225
63histone H3-K9 demethylation (GO:0033169)3.25174582
64DNA replication checkpoint (GO:0000076)3.23799336
65negative regulation of gene silencing (GO:0060969)3.23142132
66DNA geometric change (GO:0032392)3.22791804
67histone lysine methylation (GO:0034968)3.22245527
68cilium movement (GO:0003341)3.19422243
69IMP biosynthetic process (GO:0006188)3.19112645
70regulation of gamma-delta T cell activation (GO:0046643)3.18161731
71metaphase plate congression (GO:0051310)3.17374833
72regulation of mRNA catabolic process (GO:0061013)3.17368205
73positive regulation of monocyte chemotaxis (GO:0090026)3.17063140
74DNA replication-independent nucleosome organization (GO:0034724)3.16190724
75DNA replication-independent nucleosome assembly (GO:0006336)3.16190724
76positive regulation of interferon-alpha production (GO:0032727)3.14697707
77histone H3-K36 demethylation (GO:0070544)3.12867053
78DNA duplex unwinding (GO:0032508)3.10670465
79histone exchange (GO:0043486)3.08746860
80DNA replication-dependent nucleosome assembly (GO:0006335)3.08217197
81DNA replication-dependent nucleosome organization (GO:0034723)3.08217197
82regulation of meiosis I (GO:0060631)3.07595427
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07025597
84histone H3-K9 modification (GO:0061647)3.05599647
85female mating behavior (GO:0060180)3.04778034
86neural tube formation (GO:0001841)3.04640576
87protein targeting to Golgi (GO:0000042)3.03531208
88cellular response to ethanol (GO:0071361)3.02916660
89establishment of chromosome localization (GO:0051303)3.00527966
90phospholipid translocation (GO:0045332)3.00354084
91lipid translocation (GO:0034204)3.00354084
92phosphorelay signal transduction system (GO:0000160)2.99269189
93regulation of B cell differentiation (GO:0045577)2.98486864
94phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.98060398
95detection of external biotic stimulus (GO:0098581)2.95961796
96regulation of spindle organization (GO:0090224)2.95499766
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.95134916
98regulation of histone H3-K9 methylation (GO:0051570)2.95129665
99positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.94547553
100response to peptidoglycan (GO:0032494)2.94426560
101peptidyl-lysine methylation (GO:0018022)2.93467479
102regulation of translational termination (GO:0006449)2.92294281
103neutrophil mediated immunity (GO:0002446)2.92288583
104mannose metabolic process (GO:0006013)2.91351235
105regulation of interferon-alpha production (GO:0032647)2.91348411
106mitotic sister chromatid segregation (GO:0000070)2.89309361
107IMP metabolic process (GO:0046040)2.89295268
108folic acid-containing compound biosynthetic process (GO:0009396)2.89190554
109negative regulation of humoral immune response (GO:0002921)2.88832176
110meiotic chromosome segregation (GO:0045132)2.87892546
111histone H3-K4 trimethylation (GO:0080182)2.86735156
112neutrophil activation involved in immune response (GO:0002283)2.86073604
113protein localization to chromosome (GO:0034502)2.85458006
114nuclear envelope organization (GO:0006998)2.84571694
115axoneme assembly (GO:0035082)2.83325335
116negative regulation of histone methylation (GO:0031061)2.83074461
117macrophage activation involved in immune response (GO:0002281)2.82924278
118nucleosome disassembly (GO:0006337)2.81808094
119protein-DNA complex disassembly (GO:0032986)2.81808094
120chromatin assembly or disassembly (GO:0006333)2.80250139
121kinetochore assembly (GO:0051382)2.80245944
122negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.79580950
123positive regulation of mast cell activation involved in immune response (GO:0033008)2.79059419
124positive regulation of mast cell degranulation (GO:0043306)2.79059419
125regulation of protein polyubiquitination (GO:1902914)2.78829209
126regulation of mitotic spindle organization (GO:0060236)2.78628777
127sister chromatid segregation (GO:0000819)2.75223992
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72197901
129pore complex assembly (GO:0046931)2.70409967
130telomere maintenance (GO:0000723)2.70018318
131negative regulation of interleukin-6 production (GO:0032715)2.69771028
132neutrophil activation (GO:0042119)2.69046236
133iron ion import (GO:0097286)2.68207944
134regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.66782929
135telomere organization (GO:0032200)2.66586845
136hepatocyte apoptotic process (GO:0097284)2.65986986
137regulation of chromatin silencing (GO:0031935)2.65591472
138embryonic camera-type eye morphogenesis (GO:0048596)2.65519649
139DNA conformation change (GO:0071103)2.65408126
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64806497
141regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64640145
142mature B cell differentiation involved in immune response (GO:0002313)2.62034884
143centriole replication (GO:0007099)2.61982865
144histone H3-K4 methylation (GO:0051568)2.61931798
145phosphatidylethanolamine metabolic process (GO:0046337)2.61224263
146inner ear receptor cell development (GO:0060119)2.60373808
147chromosome segregation (GO:0007059)2.59769794
148formation of translation preinitiation complex (GO:0001731)2.59629946
149translesion synthesis (GO:0019985)2.59389798
150DNA strand renaturation (GO:0000733)2.59024863
151nucleobase biosynthetic process (GO:0046112)2.57879643
152protein K6-linked ubiquitination (GO:0085020)2.57478937
153V(D)J recombination (GO:0033151)2.57397972
154protein K11-linked deubiquitination (GO:0035871)2.57300020
155macrophage activation (GO:0042116)2.56228760
156positive regulation of chromosome segregation (GO:0051984)2.54936795
157regulation of germinal center formation (GO:0002634)2.54814074
158detection of biotic stimulus (GO:0009595)2.54594314
159cardiolipin metabolic process (GO:0032048)2.53964924
160determination of adult lifespan (GO:0008340)2.52523900
161regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.50344856
162cytokine biosynthetic process (GO:0042089)2.50145235
163cellular extravasation (GO:0045123)2.49961825
164maturation of 5.8S rRNA (GO:0000460)2.48553103
165myeloid leukocyte mediated immunity (GO:0002444)2.47990500
166RNA-dependent DNA replication (GO:0006278)2.47965239
167protein targeting to vacuole (GO:0006623)2.47817074
168protein targeting to lysosome (GO:0006622)2.47817074
169establishment of protein localization to vacuole (GO:0072666)2.47817074
170response to UV-C (GO:0010225)2.47652157
171DNA topological change (GO:0006265)2.46774808
172regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46504936
173positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.46257093
174positive regulation of mast cell activation (GO:0033005)2.46238782
175* regulation of double-strand break repair via homologous recombination (GO:0010569)2.46174074
176DNA synthesis involved in DNA repair (GO:0000731)2.46164768
177definitive hemopoiesis (GO:0060216)2.44672744
178replication fork processing (GO:0031297)2.44578209
179telomere maintenance via telomerase (GO:0007004)2.44498817
180negative regulation of DNA-dependent DNA replication (GO:2000104)2.42664926
181detection of light stimulus involved in visual perception (GO:0050908)2.42562054
182detection of light stimulus involved in sensory perception (GO:0050962)2.42562054
183regulation of sister chromatid cohesion (GO:0007063)2.42321787
184DNA ligation (GO:0006266)2.41855573
185regulation of nuclear cell cycle DNA replication (GO:0033262)2.41646554
186positive regulation of SMAD protein import into nucleus (GO:0060391)2.41245798
187cell wall macromolecule metabolic process (GO:0044036)2.41088334
188regulation of gene silencing (GO:0060968)2.41025697
189positive regulation of gene expression, epigenetic (GO:0045815)2.39180147
190mitotic cell cycle (GO:0000278)2.39092150
191mismatch repair (GO:0006298)2.38802153
192carnitine transmembrane transport (GO:1902603)2.37928210
193intraciliary transport (GO:0042073)2.36689436
194positive regulation of granulocyte differentiation (GO:0030854)2.36351978
195histone methylation (GO:0016571)2.33909486
196phosphatidylethanolamine biosynthetic process (GO:0006646)2.33737423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.98018836
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61189895
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.34835013
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06587705
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89611757
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.80876645
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63330966
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.62172208
9AR_21909140_ChIP-Seq_LNCAP_Human2.49803123
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.35234392
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30757281
12IGF1R_20145208_ChIP-Seq_DFB_Human2.27983053
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.17289046
14MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12669653
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07372078
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04306677
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01975680
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00748597
19E2F7_22180533_ChIP-Seq_HELA_Human10.5731255
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98557950
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98193440
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.96333461
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94242773
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.92743584
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.92487071
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88865839
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86775929
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86734866
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80636817
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78394625
31AHR_22903824_ChIP-Seq_MCF-7_Human1.76638708
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76418441
33GBX2_23144817_ChIP-Seq_PC3_Human1.76287112
34SCL_19346495_ChIP-Seq_HPC-7_Human1.74438614
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74071451
36MYC_22102868_ChIP-Seq_BL_Human1.74016118
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73802437
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.70699709
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70666318
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68380331
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68357283
42STAT3_23295773_ChIP-Seq_U87_Human1.67960395
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66066201
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63447764
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62205694
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60481523
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59702734
48DROSHA_22980978_ChIP-Seq_HELA_Human1.57460346
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57092573
50FOXP3_21729870_ChIP-Seq_TREG_Human1.56635813
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.56228028
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55323175
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54820106
54SPI1_23547873_ChIP-Seq_NB4_Human1.54185717
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52739583
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.51600529
57VDR_23849224_ChIP-Seq_CD4+_Human1.51293102
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.51089251
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.50822935
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49767081
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48657858
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46770204
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44589602
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44506646
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44285752
66XRN2_22483619_ChIP-Seq_HELA_Human1.44138179
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43590065
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42765929
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.40972276
70VDR_24787735_ChIP-Seq_THP-1_Human1.40461059
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38477722
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36683705
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35798163
74VDR_21846776_ChIP-Seq_THP-1_Human1.35432928
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.35099929
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34709900
77TCF4_23295773_ChIP-Seq_U87_Human1.34596442
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.34289970
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33724786
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33681832
81GATA3_27048872_Chip-Seq_THYMUS_Human1.33675046
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31037030
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30563992
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29513464
85SPI1_23127762_ChIP-Seq_K562_Human1.28777078
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.28661061
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.28555226
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28164570
89ELK1_19687146_ChIP-ChIP_HELA_Human1.28045431
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27709815
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26299872
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24549515
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22522083
94SMRT_27268052_Chip-Seq_Bcells_Human1.22039151
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21861794
96GABP_19822575_ChIP-Seq_HepG2_Human1.20973802
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.18277310
98TTF2_22483619_ChIP-Seq_HELA_Human1.18075891
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17525277
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16617478
101FUS_26573619_Chip-Seq_HEK293_Human1.16298314
102TP53_16413492_ChIP-PET_HCT116_Human1.15168491
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14729872
104FOXA1_25552417_ChIP-Seq_VCAP_Human1.14644218
105GATA1_22025678_ChIP-Seq_K562_Human1.14425603
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13333688
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13230592
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.13195753
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12254666
110SMAD4_21799915_ChIP-Seq_A2780_Human1.11052451
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10287386
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10119988
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09327575
114TFEB_21752829_ChIP-Seq_HELA_Human1.09240358
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08908783
116FOXA2_19822575_ChIP-Seq_HepG2_Human1.08820430
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.07888693
118MYB_26560356_Chip-Seq_TH2_Human1.07582760
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07258732
120NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07026506
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07026506
122RUNX_20019798_ChIP-Seq_JUKART_Human1.06870536
123SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06595111
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.06464404
125KDM5A_27292631_Chip-Seq_BREAST_Human1.06450800
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06404293
127GATA3_26560356_Chip-Seq_TH2_Human1.06372478
128TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06255939
129AR_21572438_ChIP-Seq_LNCaP_Human1.05339609
130MYB_26560356_Chip-Seq_TH1_Human1.05339254
131SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04463509
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.04008350
133STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03704213
134RUNX1_22412390_ChIP-Seq_EML_Mouse1.02912389
135RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02496509
136ESR2_21235772_ChIP-Seq_MCF-7_Human1.02400680
137UTX_26944678_Chip-Seq_JUKART_Human1.01598743
138VDR_24763502_ChIP-Seq_THP-1_Human1.00962819
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00637214
140ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99093973
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.98615931
142BP1_19119308_ChIP-ChIP_Hs578T_Human0.97915313
143TCF7_22412390_ChIP-Seq_EML_Mouse0.97344915
144SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97051131
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96743567
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96342574
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95302258
148PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95189449
149STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94917679
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94308859
151BRD4_25478319_ChIP-Seq_HGPS_Human0.93706530
152PU_27001747_Chip-Seq_BMDM_Mouse0.93387649
153KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93271734
154YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92253954
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91219950
156GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91008103
157SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89482047
158SRF_21415370_ChIP-Seq_HL-1_Mouse0.87289713
159TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87288247
160POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86908275
161TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86122935
162E2F1_18555785_Chip-Seq_ESCs_Mouse0.85939536
163DCP1A_22483619_ChIP-Seq_HELA_Human0.85410572
164CIITA_25753668_ChIP-Seq_RAJI_Human0.85112237
165MYC_18940864_ChIP-ChIP_HL60_Human0.85007030
166RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84630832
167TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83620893
168FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83513512
169FOXO3_23340844_ChIP-Seq_DLD1_Human0.83412666
170FLI1_21867929_ChIP-Seq_TH2_Mouse0.83377407
171MAF_26560356_Chip-Seq_TH1_Human0.83152894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.78965588
2MP0000569_abnormal_digit_pigmentation4.01003639
3MP0009697_abnormal_copulation3.81988592
4MP0004043_abnormal_pH_regulation3.43519292
5MP0010094_abnormal_chromosome_stability3.29076252
6MP0008007_abnormal_cellular_replicative3.27358168
7MP0005397_hematopoietic_system_phenotyp3.16453634
8MP0001545_abnormal_hematopoietic_system3.16453634
9MP0003111_abnormal_nucleus_morphology2.99269009
10MP0009379_abnormal_foot_pigmentation2.95283039
11MP0004147_increased_porphyrin_level2.93832207
12MP0003950_abnormal_plasma_membrane2.91411439
13MP0003693_abnormal_embryo_hatching2.83310654
14MP0003077_abnormal_cell_cycle2.65808448
15MP0002396_abnormal_hematopoietic_system2.60499448
16MP0002009_preneoplasia2.58049263
17MP0008057_abnormal_DNA_replication2.57686651
18MP0010352_gastrointestinal_tract_polyps2.50790370
19MP0004957_abnormal_blastocyst_morpholog2.46027363
20MP0000383_abnormal_hair_follicle2.45920013
21MP0008058_abnormal_DNA_repair2.44599412
22MP0005310_abnormal_salivary_gland2.38772665
23MP0003191_abnormal_cellular_cholesterol2.29901965
24MP0003705_abnormal_hypodermis_morpholog1.94787496
25MP0004808_abnormal_hematopoietic_stem1.91641450
26MP0010678_abnormal_skin_adnexa1.78408179
27MP0003172_abnormal_lysosome_physiology1.74083463
28MP0001501_abnormal_sleep_pattern1.69562761
29MP0001851_eye_inflammation1.67994898
30MP0000490_abnormal_crypts_of1.67896398
31MP0004264_abnormal_extraembryonic_tissu1.65897241
32MP0001873_stomach_inflammation1.63719874
33MP0005174_abnormal_tail_pigmentation1.60423122
34MP0004782_abnormal_surfactant_physiolog1.58266221
35MP0003183_abnormal_peptide_metabolism1.53988398
36MP0000465_gastrointestinal_hemorrhage1.51894457
37MP0010307_abnormal_tumor_latency1.51248779
38MP0004185_abnormal_adipocyte_glucose1.47406016
39MP0001835_abnormal_antigen_presentation1.47069780
40MP0003567_abnormal_fetal_cardiomyocyte1.45519939
41MP0000350_abnormal_cell_proliferation1.43342396
42MP0003045_fibrosis1.41922317
43MP0002877_abnormal_melanocyte_morpholog1.41141428
44MP0005647_abnormal_sex_gland1.39882618
45MP0003300_gastrointestinal_ulcer1.38453199
46MP0003091_abnormal_cell_migration1.37989733
47MP0005076_abnormal_cell_differentiation1.37715566
48MP0005409_darkened_coat_color1.34634300
49MP0001188_hyperpigmentation1.33136236
50MP0003786_premature_aging1.32548082
51MP0000015_abnormal_ear_pigmentation1.31222689
52MP0002168_other_aberrant_phenotype1.31033718
53MP0003787_abnormal_imprinting1.30170342
54MP0009785_altered_susceptibility_to1.29773698
55MP0004883_abnormal_blood_vessel1.28563081
56MP0005671_abnormal_response_to1.23611232
57MP0003436_decreased_susceptibility_to1.23211281
58MP0002452_abnormal_antigen_presenting1.23072975
59MP0002419_abnormal_innate_immunity1.21635898
60MP0001730_embryonic_growth_arrest1.20360351
61MP0000858_altered_metastatic_potential1.20236067
62MP0003123_paternal_imprinting1.19404134
63MP0003828_pulmonary_edema1.18587910
64MP0009764_decreased_sensitivity_to1.18066584
65MP0005025_abnormal_response_to1.17818968
66MP0002006_tumorigenesis1.16020735
67MP0002398_abnormal_bone_marrow1.16007202
68MP0002254_reproductive_system_inflammat1.12835975
69MP0003656_abnormal_erythrocyte_physiolo1.12558777
70MP0009333_abnormal_splenocyte_physiolog1.12159721
71MP0001853_heart_inflammation1.11207860
72MP0002019_abnormal_tumor_incidence1.10657853
73MP0009046_muscle_twitch1.08421198
74MP0004947_skin_inflammation1.08325896
75MP0002722_abnormal_immune_system1.06800927
76MP0005023_abnormal_wound_healing1.06757628
77MP0000313_abnormal_cell_death1.06756535
78MP0008932_abnormal_embryonic_tissue1.05481341
79MP0005171_absent_coat_pigmentation1.04852112
80MP0003763_abnormal_thymus_physiology1.04828151
81MP0001800_abnormal_humoral_immune1.03954167
82MP0004197_abnormal_fetal_growth/weight/1.02914323
83MP0002420_abnormal_adaptive_immunity1.02614641
84MP0001819_abnormal_immune_cell1.02600980
85MP0002405_respiratory_system_inflammati1.01677118
86MP0000689_abnormal_spleen_morphology1.00644098
87MP0002148_abnormal_hypersensitivity_rea1.00420241
88MP0005164_abnormal_response_to0.99929433
89MP0001958_emphysema0.99038328
90MP0010386_abnormal_urinary_bladder0.97917748
91MP0002723_abnormal_immune_serum0.97444071
92MP0000372_irregular_coat_pigmentation0.95484692
93MP0001661_extended_life_span0.95155573
94MP0003943_abnormal_hepatobiliary_system0.94905166
95MP0001697_abnormal_embryo_size0.94711239
96MP0001790_abnormal_immune_system0.94197538
97MP0005387_immune_system_phenotype0.94197538
98MP0005075_abnormal_melanosome_morpholog0.93669401
99MP0002429_abnormal_blood_cell0.93239493
100MP0001533_abnormal_skeleton_physiology0.92941884
101MP0003448_altered_tumor_morphology0.92916221
102MP0010155_abnormal_intestine_physiology0.92278761
103MP0005551_abnormal_eye_electrophysiolog0.91173135
104MP0005000_abnormal_immune_tolerance0.91068890
105MP0000716_abnormal_immune_system0.90113999
106MP0006054_spinal_hemorrhage0.90033830
107MP0005408_hypopigmentation0.88877901
108MP0001672_abnormal_embryogenesis/_devel0.88354922
109MP0005380_embryogenesis_phenotype0.88354922
110MP0001919_abnormal_reproductive_system0.87469781
111MP0005388_respiratory_system_phenotype0.86854898
112MP0002133_abnormal_respiratory_system0.86854898
113MP0002166_altered_tumor_susceptibility0.86231227
114MP0002086_abnormal_extraembryonic_tissu0.85741117
115MP0005621_abnormal_cell_physiology0.85661784
116MP0003941_abnormal_skin_development0.85588803
117MP0003890_abnormal_embryonic-extraembry0.84062999
118MP0008875_abnormal_xenobiotic_pharmacok0.82334164
119MP0006292_abnormal_olfactory_placode0.82070889
120MP0005503_abnormal_tendon_morphology0.81871162
121MP0008877_abnormal_DNA_methylation0.81695032
122MP0003984_embryonic_growth_retardation0.80877762
123MP0000427_abnormal_hair_cycle0.80787474
124MP0006072_abnormal_retinal_apoptosis0.80489803
125MP0002080_prenatal_lethality0.80183190
126MP0002085_abnormal_embryonic_tissue0.79495493
127MP0001986_abnormal_taste_sensitivity0.79381675
128MP0001293_anophthalmia0.78047228
129MP0003866_abnormal_defecation0.77714677
130MP0002088_abnormal_embryonic_growth/wei0.77703965
131MP0000685_abnormal_immune_system0.76978110
132MP0001542_abnormal_bone_strength0.76298754
133MP0008961_abnormal_basal_metabolism0.76280086
134MP0003186_abnormal_redox_activity0.75725913
135MP0000371_diluted_coat_color0.75516796
136MP0005464_abnormal_platelet_physiology0.75332873
137MP0008995_early_reproductive_senescence0.75232032
138MP0000703_abnormal_thymus_morphology0.74640565
139MP0001177_atelectasis0.74625822
140MP0005253_abnormal_eye_physiology0.74277533
141MP0003724_increased_susceptibility_to0.73393063
142MP0001119_abnormal_female_reproductive0.72715005
143MP0009703_decreased_birth_body0.71673467
144MP0005384_cellular_phenotype0.71117428
145MP0002332_abnormal_exercise_endurance0.70821322
146MP0002090_abnormal_vision0.70140148
147MP0003303_peritoneal_inflammation0.69326362
148MP0005666_abnormal_adipose_tissue0.68912090
149MP0002229_neurodegeneration0.68769325
150MP0009115_abnormal_fat_cell0.67042838
151MP0005058_abnormal_lysosome_morphology0.64259405
152MP0002653_abnormal_ependyma_morphology0.61690895
153MP0002971_abnormal_brown_adipose0.61491857

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.36334134
2Chronic bronchitis (HP:0004469)5.39920276
3Colon cancer (HP:0003003)4.17148067
4Birth length less than 3rd percentile (HP:0003561)4.10992842
5Abnormality of the fingertips (HP:0001211)3.99714199
6Abnormal respiratory motile cilium physiology (HP:0012261)3.99695110
7Chromsome breakage (HP:0040012)3.99093087
8Rhinitis (HP:0012384)3.88030423
9Recurrent abscess formation (HP:0002722)3.75546777
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74947896
11Abnormal ciliary motility (HP:0012262)3.67956930
12Absent/shortened dynein arms (HP:0200106)3.67660134
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.67660134
14IgA deficiency (HP:0002720)3.67389214
15Nephronophthisis (HP:0000090)3.46013012
16Thrombocytosis (HP:0001894)3.37246798
17Volvulus (HP:0002580)3.36522205
18Bronchitis (HP:0012387)3.35331510
19Microretrognathia (HP:0000308)3.33363642
20Reticulocytopenia (HP:0001896)3.29335877
21Spontaneous hematomas (HP:0007420)3.29076961
22Ileus (HP:0002595)3.25714681
23Petechiae (HP:0000967)3.24561864
24Nasal polyposis (HP:0100582)3.10059396
25Abnormal biliary tract physiology (HP:0012439)3.03914665
26Bile duct proliferation (HP:0001408)3.03914665
27Hematochezia (HP:0002573)2.95412891
28Bronchiectasis (HP:0002110)2.93713554
29Pancreatic islet-cell hyperplasia (HP:0004510)2.80694642
30Recurrent sinusitis (HP:0011108)2.80440473
31Abnormality of the renal medulla (HP:0100957)2.79715791
32Chronic hepatic failure (HP:0100626)2.79071333
33Autoimmune hemolytic anemia (HP:0001890)2.69156140
34Abnormal rod and cone electroretinograms (HP:0008323)2.68133800
35Abnormal respiratory motile cilium morphology (HP:0005938)2.65171421
36Abnormal respiratory epithelium morphology (HP:0012253)2.65171421
37Ectopic kidney (HP:0000086)2.63775025
38Papilledema (HP:0001085)2.62496282
39Abnormality of chromosome stability (HP:0003220)2.61923108
40Interstitial pulmonary disease (HP:0006530)2.61822389
41Genetic anticipation (HP:0003743)2.61070976
42Mediastinal lymphadenopathy (HP:0100721)2.58459559
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.56362979
44Flat capital femoral epiphysis (HP:0003370)2.53633075
45Increased cerebral lipofuscin (HP:0011813)2.51210665
46Long foot (HP:0001833)2.49317428
47Insulin resistance (HP:0000855)2.46326881
48Elevated erythrocyte sedimentation rate (HP:0003565)2.45387191
49Abnormality of the nasal mucosa (HP:0000433)2.38896049
50Reduced subcutaneous adipose tissue (HP:0003758)2.31692160
51Meckel diverticulum (HP:0002245)2.31006562
52Vaginal fistula (HP:0004320)2.29380804
53Prominent nose (HP:0000448)2.28672018
54Rectal fistula (HP:0100590)2.28663959
55Rectovaginal fistula (HP:0000143)2.28663959
56Anhidrosis (HP:0000970)2.28373187
57Increased nuchal translucency (HP:0010880)2.26659185
58Congenital, generalized hypertrichosis (HP:0004540)2.26306280
59Abnormality of the ileum (HP:0001549)2.25233730
60Myelodysplasia (HP:0002863)2.24250101
61Rough bone trabeculation (HP:0100670)2.23246016
62Cellulitis (HP:0100658)2.22514234
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.22386745
64Postaxial foot polydactyly (HP:0001830)2.20912149
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20638835
66Cystic liver disease (HP:0006706)2.19697823
67Conjunctival telangiectasia (HP:0000524)2.18762741
68Pancreatic fibrosis (HP:0100732)2.18389396
69Breast hypoplasia (HP:0003187)2.15399271
70Hypoglycemic seizures (HP:0002173)2.14843860
7111 pairs of ribs (HP:0000878)2.13090152
72Recurrent gram-negative bacterial infections (HP:0005420)2.11865535
73Abnormality of the preputium (HP:0100587)2.11837281
74Nonimmune hydrops fetalis (HP:0001790)2.10795372
75Premature graying of hair (HP:0002216)2.09993960
76Amyloidosis (HP:0011034)2.09444444
77Agnosia (HP:0010524)2.07306436
78IgM deficiency (HP:0002850)2.07031875
79Aplastic anemia (HP:0001915)2.06586688
80Congenital stationary night blindness (HP:0007642)2.06582908
81Intestinal fistula (HP:0100819)2.05400960
82Rectal prolapse (HP:0002035)2.05295101
83Elfin facies (HP:0004428)2.04906559
84Tubulointerstitial nephritis (HP:0001970)2.04651418
85True hermaphroditism (HP:0010459)2.03991980
86Autoamputation (HP:0001218)2.03852478
87Deviation of the thumb (HP:0009603)2.03784448
88Vertebral arch anomaly (HP:0008438)2.03605329
89Hypoglycemic coma (HP:0001325)2.03413205
90Reduced antithrombin III activity (HP:0001976)2.03000131
91Recurrent fungal infections (HP:0002841)2.02848006
92Absent frontal sinuses (HP:0002688)2.02594926
93Recurrent bacterial skin infections (HP:0005406)2.02216584
94Duplicated collecting system (HP:0000081)2.01687002
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01425721
96Microcytic anemia (HP:0001935)2.01352057
97Colitis (HP:0002583)2.01176868
98Proximal placement of thumb (HP:0009623)2.00150112
99Thyroiditis (HP:0100646)2.00043930
100Enlarged penis (HP:0000040)1.99600647
101Macular degeneration (HP:0000608)1.98897732
102Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98874904
103Recurrent otitis media (HP:0000403)1.95372848
104Osteomyelitis (HP:0002754)1.94903283
105Recurrent bronchitis (HP:0002837)1.94676734
106Decreased central vision (HP:0007663)1.94667027
107Spinal muscular atrophy (HP:0007269)1.94409949
108Bone marrow hypocellularity (HP:0005528)1.93820939
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93273678
110Recurrent cutaneous fungal infections (HP:0011370)1.93036177
111Chronic mucocutaneous candidiasis (HP:0002728)1.93036177
112Hypoplasia of the thymus (HP:0000778)1.92604825
113Acute myeloid leukemia (HP:0004808)1.92536125
114Thick nail (HP:0001805)1.92502175
115Abnormality of the pancreatic islet cells (HP:0006476)1.92483782
116Abnormality of endocrine pancreas physiology (HP:0012093)1.92483782
117High pitched voice (HP:0001620)1.90753364
118Overlapping toe (HP:0001845)1.90579788
119Molar tooth sign on MRI (HP:0002419)1.90323288
120Abnormality of midbrain morphology (HP:0002418)1.90323288
121Small intestinal stenosis (HP:0012848)1.89973620
122Duodenal stenosis (HP:0100867)1.89973620
123Narrow palate (HP:0000189)1.88449532
124Neurodegeneration (HP:0002180)1.88243346
125Panhypogammaglobulinemia (HP:0003139)1.88230374
126Selective tooth agenesis (HP:0001592)1.86526744
127Proximal tubulopathy (HP:0000114)1.84750098
128Prolonged bleeding time (HP:0003010)1.84625032
129Osteolytic defects of the hand bones (HP:0009699)1.83655554
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.83655554
131Abnormality of the carotid arteries (HP:0005344)1.83386669
132Eczematoid dermatitis (HP:0000976)1.82050308
133Abnormality of pyrimidine metabolism (HP:0004353)1.81774751
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79824900
135Inflammation of the large intestine (HP:0002037)1.79071651
136Gastrointestinal inflammation (HP:0004386)1.78859573
137Patellar aplasia (HP:0006443)1.78847578
138Abnormality of the renal collecting system (HP:0004742)1.78581146
139Entropion (HP:0000621)1.78471085
140Occipital encephalocele (HP:0002085)1.78470713
141Clubbing of toes (HP:0100760)1.77823776
142Truncal obesity (HP:0001956)1.76346937
143Type I transferrin isoform profile (HP:0003642)1.75447633
144Tracheoesophageal fistula (HP:0002575)1.75164781
145Myositis (HP:0100614)1.73962879
146Nephroblastoma (Wilms tumor) (HP:0002667)1.73856544
147Abnormal number of incisors (HP:0011064)1.73727559
148Oral leukoplakia (HP:0002745)1.72390712
149Autoimmune thrombocytopenia (HP:0001973)1.72002350
150Chronic otitis media (HP:0000389)1.71012799
151Neoplasm of the pancreas (HP:0002894)1.70250630
152Sloping forehead (HP:0000340)1.70242469
153Flattened epiphyses (HP:0003071)1.69552379
154Gingival bleeding (HP:0000225)1.69111841
155Neoplasm of the tracheobronchial system (HP:0100552)1.68641930
156T lymphocytopenia (HP:0005403)1.68484510
157Acute lymphatic leukemia (HP:0006721)1.67596870
158Recurrent viral infections (HP:0004429)1.67241490
159Missing ribs (HP:0000921)1.67143986
160Nephropathy (HP:0000112)1.66654674
161Blepharitis (HP:0000498)1.66254169
162Decreased skull ossification (HP:0004331)1.66217588
163Severe combined immunodeficiency (HP:0004430)1.66002230
164Absent thumb (HP:0009777)1.65373146
165Stomatitis (HP:0010280)1.65011260
166Abnormality of abdominal situs (HP:0011620)1.64738553
167Abdominal situs inversus (HP:0003363)1.64738553
168Abnormal trabecular bone morphology (HP:0100671)1.64632236
169Bell-shaped thorax (HP:0001591)1.63634886
170Atresia of the external auditory canal (HP:0000413)1.62681333
171Stage 5 chronic kidney disease (HP:0003774)1.61728945
172Pancreatic cysts (HP:0001737)1.61234940
173Constricted visual fields (HP:0001133)1.61010673
174Abnormality of skull ossification (HP:0002703)1.60022317
175Short thorax (HP:0010306)1.59931872
176Leukocytosis (HP:0001974)1.56845883
177Scanning speech (HP:0002168)1.56455782
178Granulocytopenia (HP:0001913)1.55313356
179Albinism (HP:0001022)1.54493234
180Impaired smooth pursuit (HP:0007772)1.53930099
181Abnormality of eosinophils (HP:0001879)1.53653090
182Attenuation of retinal blood vessels (HP:0007843)1.53005050
183Tachypnea (HP:0002789)1.51335520
184Atelectasis (HP:0100750)1.51137607
185Abnormality of DNA repair (HP:0003254)1.50943719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS17.15707810
2IRAK23.92735579
3NLK3.89501409
4NUAK13.60905431
5IRAK13.47544025
6INSRR3.27163418
7CDC73.26285615
8RIPK12.92791919
9WEE12.65088723
10PASK2.50400974
11AKT32.41871688
12CAMK1D2.41790253
13BUB12.41323016
14CAMK1G2.21065653
15NEK22.19574212
16FLT32.10581194
17ZAK2.09076833
18TTK2.02974291
19STK102.01568986
20TYK21.95442439
21PIM21.89556734
22NME21.83376662
23TSSK61.83311082
24MELK1.79456340
25AURKB1.69349607
26KIT1.67475375
27PLK11.64399022
28PAK41.63358690
29EIF2AK31.61499169
30TNK21.57095708
31ATR1.53747528
32GRK11.50689138
33BMPR21.48160257
34MAP4K11.47929974
35BCKDK1.47607724
36PIM11.46188738
37PKN21.45968379
38RPS6KB21.45729984
39BRSK21.39679470
40PTK2B1.39633437
41MAPK151.38585310
42EIF2AK11.36389033
43BLK1.35844789
44TGFBR11.35837163
45LRRK21.35686122
46STK161.32738902
47EEF2K1.29319987
48MKNK11.26355049
49CDK61.25735946
50NEK61.24269180
51CDK71.22362854
52CDK41.19728429
53ACVR1B1.19708242
54MAPKAPK31.18138290
55CHEK21.16209787
56ARAF1.14704852
57WNK11.13309569
58MAP3K141.11675442
59TEC1.11656566
60PLK31.10061995
61EIF2AK21.09850302
62VRK11.09500512
63STK381.04235037
64FRK1.01860647
65TRIB31.01638782
66MAP3K80.99619884
67PRKD20.99168736
68FER0.99131874
69BTK0.98191487
70RIPK40.98119334
71TXK0.97901702
72FES0.96633130
73PLK40.95818605
74JAK30.95331096
75STK40.94870790
76CSF1R0.94432813
77CHEK10.93221723
78MARK20.93037399
79YES10.93020640
80CLK10.92045771
81CDK120.90509755
82ZAP700.88103708
83EPHA20.87269774
84MAP2K20.86574976
85MAP3K70.85574064
86TRPM70.85555369
87TLK10.84916447
88MKNK20.84826191
89RAF10.84771347
90MAP2K30.83442694
91SRPK10.81545792
92TESK20.80546959
93RET0.79524612
94RPS6KA20.78923907
95EPHA30.78178502
96DYRK30.77701256
97ATM0.77504448
98RPS6KC10.77381976
99RPS6KL10.77381976
100IRAK40.75150096
101NEK90.73834907
102TAOK30.73781554
103TAOK10.73728325
104MAP3K10.71071154
105MAP3K20.70692383
106GRK60.70621824
107RPS6KA60.70171099
108DAPK20.69813953
109ITK0.69071985
110LYN0.68643729
111CDK30.66795812
112NTRK30.66662341
113KDR0.66112934
114RPS6KA40.65546477
115PDPK10.65521970
116CDK20.64916146
117IKBKB0.64343238
118PRKCI0.63470906
119AURKA0.63198991
120PIK3CA0.63067511
121CDK90.61473660
122CSK0.60645544
123NEK10.58284321
124SMG10.57971744
125PIK3CG0.57946108
126CSNK2A20.57245411
127CHUK0.57155488
128CSNK2A10.56690871
129STK30.54464619
130MTOR0.53919800
131MAP3K50.53642834
132MAP3K100.53532445
133HIPK20.53120330
134PDK10.52717605
135HCK0.52353412
136LCK0.51823321
137BRD40.51500187
138JAK20.50556678
139CDK80.49834115
140JAK10.49832752
141MAP3K60.48132858
142ALK0.47507082
143NME10.44296476
144CAMK10.43297202
145DAPK10.42929210
146PDK20.42877876
147PRKD10.42391666
148MAPK70.42357720
149PDGFRB0.41526627
150CDK10.40217491
151SCYL20.40065745
152MATK0.40013381
153MAPK120.38306290
154IKBKE0.37966412
155MAP2K40.37634207
156CAMKK10.37220184
157CAMK40.36964455
158TBK10.36263791
159RPS6KA50.36261716
160SYK0.35884097
161MAPK110.35600779
162ERBB30.33923709
163BRSK10.33474840
164TGFBR20.32879456

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.59396617
2Mismatch repair_Homo sapiens_hsa034303.47805267
3Cell cycle_Homo sapiens_hsa041102.75995084
4Homologous recombination_Homo sapiens_hsa034402.70395589
5Base excision repair_Homo sapiens_hsa034102.66208873
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40479134
7One carbon pool by folate_Homo sapiens_hsa006702.39939838
8Spliceosome_Homo sapiens_hsa030402.34731761
9Nucleotide excision repair_Homo sapiens_hsa034202.25634635
10RNA transport_Homo sapiens_hsa030132.23243037
11Fanconi anemia pathway_Homo sapiens_hsa034602.13370858
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00962468
13Vitamin B6 metabolism_Homo sapiens_hsa007501.90176757
14RNA degradation_Homo sapiens_hsa030181.90127108
15Inositol phosphate metabolism_Homo sapiens_hsa005621.81731387
16Non-homologous end-joining_Homo sapiens_hsa034501.78521626
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78175703
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.74703828
19Ribosome_Homo sapiens_hsa030101.70310451
20p53 signaling pathway_Homo sapiens_hsa041151.65810769
21Pyrimidine metabolism_Homo sapiens_hsa002401.61323791
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59211933
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.57802812
24Regulation of autophagy_Homo sapiens_hsa041401.54896168
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53876306
26mTOR signaling pathway_Homo sapiens_hsa041501.48288666
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.43940895
28RNA polymerase_Homo sapiens_hsa030201.42213811
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33712901
30Shigellosis_Homo sapiens_hsa051311.30610597
31Proteasome_Homo sapiens_hsa030501.30083852
32Herpes simplex infection_Homo sapiens_hsa051681.29520876
33Legionellosis_Homo sapiens_hsa051341.28603811
34Antigen processing and presentation_Homo sapiens_hsa046121.28454377
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27327614
36Non-small cell lung cancer_Homo sapiens_hsa052231.27301361
37Basal transcription factors_Homo sapiens_hsa030221.26727358
38ABC transporters_Homo sapiens_hsa020101.26204145
39Folate biosynthesis_Homo sapiens_hsa007901.26081085
40Choline metabolism in cancer_Homo sapiens_hsa052311.21875483
41Dorso-ventral axis formation_Homo sapiens_hsa043201.20064756
42Leishmaniasis_Homo sapiens_hsa051401.17811182
43MicroRNAs in cancer_Homo sapiens_hsa052061.14700314
44Measles_Homo sapiens_hsa051621.14462958
45Sphingolipid metabolism_Homo sapiens_hsa006001.11174124
46Pertussis_Homo sapiens_hsa051331.11045661
47VEGF signaling pathway_Homo sapiens_hsa043701.11032557
48Apoptosis_Homo sapiens_hsa042101.09572069
49Fatty acid elongation_Homo sapiens_hsa000621.09437664
50Viral carcinogenesis_Homo sapiens_hsa052031.08747834
51Systemic lupus erythematosus_Homo sapiens_hsa053221.06056653
52Prolactin signaling pathway_Homo sapiens_hsa049171.04119637
53Small cell lung cancer_Homo sapiens_hsa052221.03783035
54Ether lipid metabolism_Homo sapiens_hsa005651.03592056
55Epstein-Barr virus infection_Homo sapiens_hsa051691.02972305
56Leukocyte transendothelial migration_Homo sapiens_hsa046701.02645320
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.00657657
58ErbB signaling pathway_Homo sapiens_hsa040120.98587332
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94926625
60Renin secretion_Homo sapiens_hsa049240.94099640
61Chronic myeloid leukemia_Homo sapiens_hsa052200.93295983
62Thyroid cancer_Homo sapiens_hsa052160.93293372
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92304877
64T cell receptor signaling pathway_Homo sapiens_hsa046600.91293291
65HTLV-I infection_Homo sapiens_hsa051660.88492696
66Primary immunodeficiency_Homo sapiens_hsa053400.88219205
67Salivary secretion_Homo sapiens_hsa049700.87464161
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.83750652
69Influenza A_Homo sapiens_hsa051640.83722102
70Lysosome_Homo sapiens_hsa041420.83501866
71FoxO signaling pathway_Homo sapiens_hsa040680.82671232
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82590167
73Hematopoietic cell lineage_Homo sapiens_hsa046400.81729113
74Adherens junction_Homo sapiens_hsa045200.81006032
75Hepatitis B_Homo sapiens_hsa051610.79771527
76mRNA surveillance pathway_Homo sapiens_hsa030150.78821269
77Malaria_Homo sapiens_hsa051440.78416802
78GnRH signaling pathway_Homo sapiens_hsa049120.75962793
79Colorectal cancer_Homo sapiens_hsa052100.75927169
80Selenocompound metabolism_Homo sapiens_hsa004500.75683368
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.75473699
82Estrogen signaling pathway_Homo sapiens_hsa049150.73093613
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72513895
84Long-term potentiation_Homo sapiens_hsa047200.71557974
85Pancreatic cancer_Homo sapiens_hsa052120.68301163
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68228193
87Purine metabolism_Homo sapiens_hsa002300.67654640
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67641622
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.67268687
90Toxoplasmosis_Homo sapiens_hsa051450.66753610
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66413565
92Calcium signaling pathway_Homo sapiens_hsa040200.65676665
93B cell receptor signaling pathway_Homo sapiens_hsa046620.64723255
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63810001
95Insulin resistance_Homo sapiens_hsa049310.63200464
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62280863
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59628226
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59408691
99Cholinergic synapse_Homo sapiens_hsa047250.59314665
100Pancreatic secretion_Homo sapiens_hsa049720.58909780
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58635055
102Serotonergic synapse_Homo sapiens_hsa047260.58393510
103Osteoclast differentiation_Homo sapiens_hsa043800.57953980
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57253602
105Amoebiasis_Homo sapiens_hsa051460.57077643
106Histidine metabolism_Homo sapiens_hsa003400.56030916
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54989960
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54698278
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54545065
110Hepatitis C_Homo sapiens_hsa051600.53470524
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52269923
112African trypanosomiasis_Homo sapiens_hsa051430.51037275
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50639317
114Endocytosis_Homo sapiens_hsa041440.50398161
115Bladder cancer_Homo sapiens_hsa052190.49419771
116TGF-beta signaling pathway_Homo sapiens_hsa043500.48862198
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.48539149
118Staphylococcus aureus infection_Homo sapiens_hsa051500.48059427
119Pathways in cancer_Homo sapiens_hsa052000.47808880
120Type II diabetes mellitus_Homo sapiens_hsa049300.47569183
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47139473
122Alcoholism_Homo sapiens_hsa050340.47128191
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47024728
124Linoleic acid metabolism_Homo sapiens_hsa005910.46738684
125Protein export_Homo sapiens_hsa030600.46273614
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46200530
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45575600
128Acute myeloid leukemia_Homo sapiens_hsa052210.45490024
129Lysine degradation_Homo sapiens_hsa003100.45485976
130HIF-1 signaling pathway_Homo sapiens_hsa040660.45330685
131Morphine addiction_Homo sapiens_hsa050320.45308425
132Long-term depression_Homo sapiens_hsa047300.45300517
133Fatty acid biosynthesis_Homo sapiens_hsa000610.45173782
134TNF signaling pathway_Homo sapiens_hsa046680.45138153
135Platelet activation_Homo sapiens_hsa046110.44536905
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44038270
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43744692
138Chemical carcinogenesis_Homo sapiens_hsa052040.43495393
139Prostate cancer_Homo sapiens_hsa052150.43185065
140Salmonella infection_Homo sapiens_hsa051320.41536361
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40317166
142Other glycan degradation_Homo sapiens_hsa005110.39781967
143Allograft rejection_Homo sapiens_hsa053300.39522189
144Graft-versus-host disease_Homo sapiens_hsa053320.39154946
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.39003670
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38709710
147Tuberculosis_Homo sapiens_hsa051520.37649514
148Glutathione metabolism_Homo sapiens_hsa004800.36976885
149Oocyte meiosis_Homo sapiens_hsa041140.36465411
150Viral myocarditis_Homo sapiens_hsa054160.35717989
151Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35453669
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35328690
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.34251603
154Rheumatoid arthritis_Homo sapiens_hsa053230.33660575

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