SPHK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lipopolysaccharide biosynthetic process (GO:0009103)6.60611547
2DNA methylation involved in gamete generation (GO:0043046)6.31281638
3protein-chromophore linkage (GO:0018298)6.20177723
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.91830551
5L-phenylalanine metabolic process (GO:0006558)5.91830551
6L-phenylalanine catabolic process (GO:0006559)5.83183129
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.83183129
8lipopolysaccharide metabolic process (GO:0008653)5.75310065
9meiotic chromosome segregation (GO:0045132)5.67937841
10protein retention in ER lumen (GO:0006621)5.61278047
11sulfate transmembrane transport (GO:1902358)5.44683391
12GDP-mannose metabolic process (GO:0019673)5.30663128
13* sphingosine metabolic process (GO:0006670)5.29718734
14regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.15252918
15proline biosynthetic process (GO:0006561)5.12566497
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.08595009
17negative regulation of glycoprotein biosynthetic process (GO:0010561)5.07903272
18iron coordination entity transport (GO:1901678)5.00234002
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.99724418
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.88947712
21cellular response to ATP (GO:0071318)4.77653571
22aromatic amino acid family catabolic process (GO:0009074)4.70826998
23* diol metabolic process (GO:0034311)4.67254995
24sulfate transport (GO:0008272)4.63625533
25paraxial mesoderm development (GO:0048339)4.61824712
26piRNA metabolic process (GO:0034587)4.61528600
27negative regulation of cell cycle G2/M phase transition (GO:1902750)4.52817134
28sulfur amino acid catabolic process (GO:0000098)4.51040776
29alpha-linolenic acid metabolic process (GO:0036109)4.35831492
30proline metabolic process (GO:0006560)4.34406226
31peptidyl-glutamic acid carboxylation (GO:0017187)4.29463261
32protein carboxylation (GO:0018214)4.29463261
33regulation of triglyceride catabolic process (GO:0010896)4.28596554
34regulation of nuclear cell cycle DNA replication (GO:0033262)4.26431723
35urea cycle (GO:0000050)4.23327039
36urea metabolic process (GO:0019627)4.23327039
37plasma lipoprotein particle clearance (GO:0034381)4.20799489
38cysteine metabolic process (GO:0006534)4.20723600
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.19142811
40phospholipid efflux (GO:0033700)4.15240320
41high-density lipoprotein particle remodeling (GO:0034375)4.10175150
42glyoxylate metabolic process (GO:0046487)4.10059544
43* sphingoid metabolic process (GO:0046519)4.08115929
44regulation of cholesterol homeostasis (GO:2000188)4.07297594
45regulation of synapse structural plasticity (GO:0051823)4.04410592
46DNA strand renaturation (GO:0000733)4.03716359
47regulation of protein glycosylation (GO:0060049)4.02296232
48kynurenine metabolic process (GO:0070189)4.00981629
49bile acid biosynthetic process (GO:0006699)3.99679668
50positive regulation of developmental pigmentation (GO:0048087)3.91335124
51nitrogen cycle metabolic process (GO:0071941)3.89892151
52regulation of cholesterol esterification (GO:0010872)3.88933507
53complement activation, alternative pathway (GO:0006957)3.88670369
54negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.87445427
55negative regulation of glycoprotein metabolic process (GO:1903019)3.85896164
56negative regulation of fibrinolysis (GO:0051918)3.85735117
57vitamin transmembrane transport (GO:0035461)3.85492119
58adenosine receptor signaling pathway (GO:0001973)3.84579942
59indole-containing compound catabolic process (GO:0042436)3.82482256
60indolalkylamine catabolic process (GO:0046218)3.82482256
61tryptophan catabolic process (GO:0006569)3.82482256
62phosphatidylglycerol biosynthetic process (GO:0006655)3.82263121
63pantothenate metabolic process (GO:0015939)3.81586628
64intestinal cholesterol absorption (GO:0030299)3.78873550
65negative regulation of cholesterol transport (GO:0032375)3.78313076
66negative regulation of sterol transport (GO:0032372)3.78313076
67regulation of meiosis I (GO:0060631)3.70430124
68regulation of fibrinolysis (GO:0051917)3.69035209
69reverse cholesterol transport (GO:0043691)3.66920227
70flavonoid metabolic process (GO:0009812)3.61257960
71serine family amino acid catabolic process (GO:0009071)3.60793171
72tryptophan metabolic process (GO:0006568)3.60398642
73plasma lipoprotein particle assembly (GO:0034377)3.60146564
74regulation of protein activation cascade (GO:2000257)3.58319375
75mannose metabolic process (GO:0006013)3.58054347
76sulfur compound transport (GO:0072348)3.57691968
77negative regulation of cell aging (GO:0090344)3.57115569
78notochord development (GO:0030903)3.56621059
79bile acid metabolic process (GO:0008206)3.56520375
80cholesterol efflux (GO:0033344)3.56479255
81regulation of skeletal muscle contraction (GO:0014819)3.55985464
82positive regulation of triglyceride lipase activity (GO:0061365)3.55556126
83positive regulation of lipoprotein lipase activity (GO:0051006)3.55556126
84homocysteine metabolic process (GO:0050667)3.54978226
85gamma-aminobutyric acid signaling pathway (GO:0007214)3.54273901
86synaptic vesicle docking involved in exocytosis (GO:0016081)3.53999432
87ethanol oxidation (GO:0006069)3.48981178
88cellular modified amino acid catabolic process (GO:0042219)3.48568756
89trivalent inorganic anion homeostasis (GO:0072506)3.47504000
90phosphate ion homeostasis (GO:0055062)3.47504000
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.47251650
92triglyceride homeostasis (GO:0070328)3.46367977
93acylglycerol homeostasis (GO:0055090)3.46367977
94protein-lipid complex remodeling (GO:0034368)3.45628874
95macromolecular complex remodeling (GO:0034367)3.45628874
96plasma lipoprotein particle remodeling (GO:0034369)3.45628874
97amino-acid betaine metabolic process (GO:0006577)3.45542262
98protein-lipid complex assembly (GO:0065005)3.45022261
99aromatic amino acid family metabolic process (GO:0009072)3.41006133
100ethanol metabolic process (GO:0006067)3.39817558
101regulation of complement activation (GO:0030449)3.37507050
102regulation of pigment cell differentiation (GO:0050932)3.36540798
103cholesterol homeostasis (GO:0042632)3.36363552
104nodal signaling pathway (GO:0038092)3.35353004
105positive regulation of lipid catabolic process (GO:0050996)3.33550404
106SMAD protein complex assembly (GO:0007183)3.33051316
107low-density lipoprotein particle clearance (GO:0034383)3.32032726
108sterol homeostasis (GO:0055092)3.30976768
109positive regulation of fatty acid biosynthetic process (GO:0045723)3.30625685
110DNA damage induced protein phosphorylation (GO:0006975)3.28106941
111lysine metabolic process (GO:0006553)3.24883338
112lysine catabolic process (GO:0006554)3.24883338
113glycine metabolic process (GO:0006544)3.24348790
114nucleoside transmembrane transport (GO:1901642)3.23888946
115positive regulation of triglyceride metabolic process (GO:0090208)3.22284608
116primary alcohol catabolic process (GO:0034310)3.20942576
117amyloid precursor protein catabolic process (GO:0042987)3.20025354
118tyrosine metabolic process (GO:0006570)3.17353862
119phospholipid homeostasis (GO:0055091)3.15647809
120short-chain fatty acid metabolic process (GO:0046459)3.15152083
121phosphatidylethanolamine metabolic process (GO:0046337)3.14428013
122adenine nucleotide transport (GO:0051503)3.13966033
123fibrinolysis (GO:0042730)3.13556713
124alpha-amino acid catabolic process (GO:1901606)3.13538663
125coenzyme catabolic process (GO:0009109)3.13316738
126serine family amino acid metabolic process (GO:0009069)3.10901366
127negative regulation of lipase activity (GO:0060192)3.09810995
128response to mercury ion (GO:0046689)3.09538824
129bile acid and bile salt transport (GO:0015721)3.08763077
130regulation of cholesterol metabolic process (GO:0090181)3.07782117
131cofactor catabolic process (GO:0051187)3.05699538
132regulation of cholesterol biosynthetic process (GO:0045540)3.03657428
133heme transport (GO:0015886)3.03435179
134postsynaptic membrane organization (GO:0001941)3.02793981
135semaphorin-plexin signaling pathway (GO:0071526)3.02626560
136regulation of ARF GTPase activity (GO:0032312)3.01229750
137drug catabolic process (GO:0042737)3.00847955
138cellular amino acid catabolic process (GO:0009063)3.00674263
139positive regulation of fatty acid beta-oxidation (GO:0032000)3.00149443
140glutamate metabolic process (GO:0006536)3.00121587
141lipoprotein metabolic process (GO:0042157)2.99838508
142very-low-density lipoprotein particle assembly (GO:0034379)2.99547564
143folic acid metabolic process (GO:0046655)2.98760007
144aldehyde catabolic process (GO:0046185)2.97796368
145very long-chain fatty acid metabolic process (GO:0000038)2.97408092
146acetyl-CoA metabolic process (GO:0006084)2.97366915
147imidazole-containing compound metabolic process (GO:0052803)2.97002180
148biotin metabolic process (GO:0006768)2.96683465
149phosphatidylethanolamine biosynthetic process (GO:0006646)2.96570529
150cofactor transport (GO:0051181)2.96529640
151intestinal absorption (GO:0050892)2.96195034
152regulation of cytokine production involved in inflammatory response (GO:1900015)2.95791591
153fatty acid beta-oxidation (GO:0006635)2.95237292
154regulation of cholesterol storage (GO:0010885)2.94561994
155positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94253291
156plasma lipoprotein particle organization (GO:0071827)2.93708187
157regulation of triglyceride metabolic process (GO:0090207)2.93576795
158heart valve formation (GO:0003188)2.93262765
159DNA methylation (GO:0006306)2.92764679
160DNA alkylation (GO:0006305)2.92764679
161fatty acid catabolic process (GO:0009062)2.91354091
162cellular ketone body metabolic process (GO:0046950)2.91256157
163serine family amino acid biosynthetic process (GO:0009070)2.90989689
164fatty acid oxidation (GO:0019395)2.90330836
165protein-lipid complex subunit organization (GO:0071825)2.89212680
166ionotropic glutamate receptor signaling pathway (GO:0035235)2.88801469
167purine ribonucleotide transport (GO:0015868)2.88018829
168drug transmembrane transport (GO:0006855)2.86405405
169dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.83437374
170lens fiber cell differentiation (GO:0070306)2.82240061
171peptidyl-tyrosine autophosphorylation (GO:0038083)2.80434370
172detection of light stimulus involved in sensory perception (GO:0050962)2.78366145
173detection of light stimulus involved in visual perception (GO:0050908)2.78366145
174transepithelial transport (GO:0070633)2.77390700
175purine nucleotide transport (GO:0015865)2.76667924
176regulation of interleukin-5 production (GO:0032674)2.75447006
177positive regulation of catecholamine secretion (GO:0033605)2.75428880
178regulation of developmental pigmentation (GO:0048070)2.73933548
179purinergic nucleotide receptor signaling pathway (GO:0035590)2.73886812
180negative regulation of stem cell proliferation (GO:2000647)2.73439232
181UV protection (GO:0009650)2.67249673
182peristalsis (GO:0030432)2.64336327
183mitotic cell cycle arrest (GO:0071850)2.61651574
184positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60480265
185germinal center formation (GO:0002467)2.58909486
186positive regulation of histone deacetylation (GO:0031065)2.58855557
187serotonin receptor signaling pathway (GO:0007210)2.57855493
188positive regulation of fatty acid oxidation (GO:0046321)2.57034630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.29358578
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.29588163
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.91007538
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.14037603
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.78479346
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.68673780
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.52536985
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.27195638
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.20042047
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92107517
11* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.73090017
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.43527877
13CTCF_27219007_Chip-Seq_Bcells_Human2.39153429
14E2F1_20622854_ChIP-Seq_HELA_Human2.38567348
15SMC4_20622854_ChIP-Seq_HELA_Human2.27329803
16* PHF8_20622854_ChIP-Seq_HELA_Human2.11083360
17TET1_21451524_ChIP-Seq_MESCs_Mouse2.08592143
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05032118
19LXR_22292898_ChIP-Seq_THP-1_Human1.97848340
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95311131
21MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.94057541
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89555745
23* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.87070267
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86985527
25RARB_24833708_ChIP-Seq_LIVER_Mouse1.86376636
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86141245
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.83938379
28* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.82021236
29RARA_24833708_ChIP-Seq_LIVER_Mouse1.80001140
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.73316622
31STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.73258411
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72479106
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.71830384
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.67988653
35TP53_22127205_ChIP-Seq_IMR90_Human1.66244723
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65804178
37CTCF_20526341_ChIP-Seq_ESCs_Human1.64952270
38* FOXP1_21924763_ChIP-Seq_HESCs_Human1.63504421
39RXRA_24833708_ChIP-Seq_LIVER_Mouse1.62481163
40RACK7_27058665_Chip-Seq_MCF-7_Human1.61960517
41VDR_21846776_ChIP-Seq_THP-1_Human1.60271235
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58836803
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54809957
44TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.54774201
45AR_21572438_ChIP-Seq_LNCaP_Human1.52865796
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52855175
47XRN2_22483619_ChIP-Seq_HELA_Human1.52800050
48OCT4_19829295_ChIP-Seq_ESCs_Human1.52725682
49* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52506975
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.51314179
51* ELK3_25401928_ChIP-Seq_HUVEC_Human1.49874352
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48884480
53OCT4_20526341_ChIP-Seq_ESCs_Human1.48697526
54JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.47378693
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47141671
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.46695551
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45828919
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44106965
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.42850979
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42332765
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42280847
62* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40340952
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39351211
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38936689
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38170351
66* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37122589
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37045032
68DROSHA_22980978_ChIP-Seq_HELA_Human1.35357512
69ETS1_21867929_ChIP-Seq_TH2_Mouse1.35171296
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.35022675
71CTCF_26484167_Chip-Seq_Bcells_Mouse1.33931684
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33502894
73CLOCK_20551151_ChIP-Seq_293T_Human1.33065248
74ZNF263_19887448_ChIP-Seq_K562_Human1.32139623
75FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31316663
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31206743
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29512993
78KDM2B_26808549_Chip-Seq_K562_Human1.28863785
79ERA_21632823_ChIP-Seq_H3396_Human1.28630861
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27406903
81TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27186743
82SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26914264
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26739004
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26571778
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26463451
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.24690069
87KDM2B_26808549_Chip-Seq_DND41_Human1.24436219
88RAC3_21632823_ChIP-Seq_H3396_Human1.24055890
89* TCF7_22412390_ChIP-Seq_EML_Mouse1.22995326
90GATA6_25053715_ChIP-Seq_YYC3_Human1.22290867
91BCOR_27268052_Chip-Seq_Bcells_Human1.21907378
92MAF_26560356_Chip-Seq_TH1_Human1.21502534
93SPI1_20517297_ChIP-Seq_HL60_Human1.20598301
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19921922
95ATF3_27146783_Chip-Seq_COLON_Human1.19512220
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17211428
97P300_27268052_Chip-Seq_Bcells_Human1.16315629
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15926658
99P53_21459846_ChIP-Seq_SAOS-2_Human1.14630662
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13754297
101RARB_27405468_Chip-Seq_BRAIN_Mouse1.13599928
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13142038
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12852188
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12588733
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.11742912
106NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.11587691
107NANOG_20526341_ChIP-Seq_ESCs_Human1.11316777
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.10826985
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.10483251
110GATA1_22025678_ChIP-Seq_K562_Human1.10373525
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10303209
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08738516
113VDR_24763502_ChIP-Seq_THP-1_Human1.08564424
114TAF2_19829295_ChIP-Seq_ESCs_Human1.08269209
115FOXA2_19822575_ChIP-Seq_HepG2_Human1.08136731
116KLF4_19829295_ChIP-Seq_ESCs_Human1.08020646
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07968249
118MYC_22102868_ChIP-Seq_BL_Human1.07789344
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07393118
120GATA3_21867929_ChIP-Seq_CD8_Mouse1.07257692
121* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06676881
122* UTX_26944678_Chip-Seq_JUKART_Human1.06611410
123GATA1_19941827_ChIP-Seq_MEL_Mouse1.06468829
124GATA4_25053715_ChIP-Seq_YYC3_Human1.05920173
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05711270
126GATA1_19941826_ChIP-Seq_K562_Human1.05550439
127MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03999089
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03265612
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00738155
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99793817
131CREB1_26743006_Chip-Seq_LNCaP_Human0.99659709
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99420775
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98714788
134* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98426658
135P68_20966046_ChIP-Seq_HELA_Human0.97750998
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95995648
137MAF_26560356_Chip-Seq_TH2_Human0.95478294
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.93296864
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92727796
140GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92353933
141BCL6_27268052_Chip-Seq_Bcells_Human0.92067164
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91411421
143HNF4A_19822575_ChIP-Seq_HepG2_Human0.90311819
144SCL_19346495_ChIP-Seq_HPC-7_Human0.88958355
145CTCF_21964334_Chip-Seq_Bcells_Human0.88766159
146CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87676023
147CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87486913
148CDX2_20551321_ChIP-Seq_CACO-2_Human0.87136710
149CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85854153
150SA1_27219007_Chip-Seq_Bcells_Human0.85596147
151* RUNX1_22412390_ChIP-Seq_EML_Mouse0.85205478
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84909821
153TP63_22573176_ChIP-Seq_HFKS_Human0.84857477
154SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84478569
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.84427911
156BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84207358
157UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83554974
158STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83082939
159* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83064152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation8.57302413
2MP0003136_yellow_coat_color7.88687597
3MP0002139_abnormal_hepatobiliary_system5.79444077
4MP0002837_dystrophic_cardiac_calcinosis5.56140532
5MP0005360_urolithiasis5.55909100
6MP0002653_abnormal_ependyma_morphology4.35541160
7MP0009840_abnormal_foam_cell4.27525290
8MP0005365_abnormal_bile_salt4.27208034
9MP0005085_abnormal_gallbladder_physiolo4.17370412
10MP0008875_abnormal_xenobiotic_pharmacok3.53666406
11MP0003045_fibrosis3.27600481
12MP0003191_abnormal_cellular_cholesterol3.14097155
13MP0001986_abnormal_taste_sensitivity3.09043039
14MP0005423_abnormal_somatic_nervous3.02139351
15MP0005174_abnormal_tail_pigmentation2.98265899
16MP0003879_abnormal_hair_cell2.94534003
17MP0003806_abnormal_nucleotide_metabolis2.90546395
18MP0005083_abnormal_biliary_tract2.80028307
19MP0010329_abnormal_lipoprotein_level2.70408791
20MP0001666_abnormal_nutrient_absorption2.59350701
21MP0003252_abnormal_bile_duct2.56429200
22MP0003890_abnormal_embryonic-extraembry2.45043594
23MP0003195_calcinosis2.38581949
24MP0005058_abnormal_lysosome_morphology2.35165858
25MP0002796_impaired_skin_barrier2.13871184
26MP0005332_abnormal_amino_acid2.09375903
27MP0003705_abnormal_hypodermis_morpholog1.98627099
28MP0000609_abnormal_liver_physiology1.98127268
29MP0001968_abnormal_touch/_nociception1.87675995
30MP0003303_peritoneal_inflammation1.85996217
31MP0002118_abnormal_lipid_homeostasis1.85450386
32MP0005451_abnormal_body_composition1.81663481
33MP0003646_muscle_fatigue1.77137511
34MP0004147_increased_porphyrin_level1.74772800
35MP0000604_amyloidosis1.67218849
36MP0002735_abnormal_chemical_nociception1.67105766
37MP0003300_gastrointestinal_ulcer1.65875115
38MP0004185_abnormal_adipocyte_glucose1.62275480
39MP0003436_decreased_susceptibility_to1.61035816
40MP0004019_abnormal_vitamin_homeostasis1.59484260
41MP0004947_skin_inflammation1.57033793
42MP0005076_abnormal_cell_differentiation1.56320557
43MP0002254_reproductive_system_inflammat1.53355551
44MP0009643_abnormal_urine_homeostasis1.50800503
45MP0002138_abnormal_hepatobiliary_system1.50750446
46MP0006082_CNS_inflammation1.49816202
47MP0005319_abnormal_enzyme/_coenzyme1.47632596
48MP0003656_abnormal_erythrocyte_physiolo1.38484166
49MP0001661_extended_life_span1.32903488
50MP0003453_abnormal_keratinocyte_physiol1.31503109
51MP0005377_hearing/vestibular/ear_phenot1.26370953
52MP0003878_abnormal_ear_physiology1.26370953
53MP0004859_abnormal_synaptic_plasticity1.24745541
54MP0005584_abnormal_enzyme/coenzyme_acti1.24049536
55MP0005330_cardiomyopathy1.23368589
56MP0002736_abnormal_nociception_after1.21873409
57MP0008469_abnormal_protein_level1.21469753
58MP0005501_abnormal_skin_physiology1.20316582
59MP0001502_abnormal_circadian_rhythm1.19585259
60MP0002160_abnormal_reproductive_system1.17954991
61MP0003868_abnormal_feces_composition1.15207918
62MP0003329_amyloid_beta_deposits1.14912728
63MP0010234_abnormal_vibrissa_follicle1.13090602
64MP0005464_abnormal_platelet_physiology1.12985565
65MP0001188_hyperpigmentation1.11142618
66MP0002168_other_aberrant_phenotype1.09895752
67MP0005410_abnormal_fertilization1.08960837
68MP0003137_abnormal_impulse_conducting1.08484049
69MP0000015_abnormal_ear_pigmentation1.08428410
70MP0005025_abnormal_response_to1.04675633
71MP0000598_abnormal_liver_morphology1.04568115
72MP0002075_abnormal_coat/hair_pigmentati1.03998517
73MP0001790_abnormal_immune_system1.03638744
74MP0005387_immune_system_phenotype1.03638744
75MP0000685_abnormal_immune_system1.03228502
76MP0001216_abnormal_epidermal_layer1.02901138
77MP0005666_abnormal_adipose_tissue1.02740673
78MP0000579_abnormal_nail_morphology1.00168935
79MP0003635_abnormal_synaptic_transmissio0.99740702
80MP0001970_abnormal_pain_threshold0.98469908
81MP0002419_abnormal_innate_immunity0.97216821
82MP0003724_increased_susceptibility_to0.96615080
83MP0005409_darkened_coat_color0.96205154
84MP0005075_abnormal_melanosome_morpholog0.96012865
85MP0002060_abnormal_skin_morphology0.96001091
86MP0004381_abnormal_hair_follicle0.92877176
87MP0005636_abnormal_mineral_homeostasis0.92621574
88MP0009763_increased_sensitivity_to0.91725584
89MP0001764_abnormal_homeostasis0.90802814
90MP0001845_abnormal_inflammatory_respons0.88164320
91MP0001664_abnormal_digestion0.87633362
92MP0003075_altered_response_to0.86186475
93MP0003690_abnormal_glial_cell0.86099345
94MP0000749_muscle_degeneration0.85561557
95MP0002064_seizures0.85262067
96MP0003186_abnormal_redox_activity0.84242174
97MP0001533_abnormal_skeleton_physiology0.84031757
98MP0001851_eye_inflammation0.83443883
99MP0002098_abnormal_vibrissa_morphology0.83312044
100MP0002938_white_spotting0.83280140
101MP0009642_abnormal_blood_homeostasis0.82940817
102MP0009764_decreased_sensitivity_to0.81805743
103MP0001486_abnormal_startle_reflex0.81701058
104MP0009785_altered_susceptibility_to0.78861528
105MP0003172_abnormal_lysosome_physiology0.78496323
106MP0004043_abnormal_pH_regulation0.77689464
107MP0000377_abnormal_hair_follicle0.76467498
108MP0004130_abnormal_muscle_cell0.76210219
109MP0005000_abnormal_immune_tolerance0.75276975
110MP0000467_abnormal_esophagus_morphology0.74840331
111MP0002971_abnormal_brown_adipose0.74559401
112MP0003011_delayed_dark_adaptation0.74447074
113MP0008569_lethality_at_weaning0.74114244
114MP0002136_abnormal_kidney_physiology0.73501936
115MP0010155_abnormal_intestine_physiology0.73331813
116MP0000538_abnormal_urinary_bladder0.72604984
117MP0002078_abnormal_glucose_homeostasis0.72370293
118MP0003111_abnormal_nucleus_morphology0.72293011
119MP0001243_abnormal_dermal_layer0.72256661
120MP0008770_decreased_survivor_rate0.71898792
121MP0002272_abnormal_nervous_system0.71524175
122MP0009931_abnormal_skin_appearance0.71375755
123MP0005670_abnormal_white_adipose0.71007867
124MP0000751_myopathy0.70828786
125MP0003566_abnormal_cell_adhesion0.70705465
126MP0009745_abnormal_behavioral_response0.70698461
127MP0009278_abnormal_bone_marrow0.70612969
128MP0000470_abnormal_stomach_morphology0.70489008
129MP0005375_adipose_tissue_phenotype0.70134933
130MP0004510_myositis0.69529212
131MP0005551_abnormal_eye_electrophysiolog0.68664601
132MP0001765_abnormal_ion_homeostasis0.68420391
133MP0001800_abnormal_humoral_immune0.68382280
134MP0002063_abnormal_learning/memory/cond0.68249112
135MP0002723_abnormal_immune_serum0.68096153
136MP0001756_abnormal_urination0.67791439
137MP0005023_abnormal_wound_healing0.67471211
138MP0002572_abnormal_emotion/affect_behav0.66134001
139MP0005220_abnormal_exocrine_pancreas0.65081017
140MP0001849_ear_inflammation0.65037004
141MP0008961_abnormal_basal_metabolism0.63963890
142MP0005334_abnormal_fat_pad0.63361411
143MP0004233_abnormal_muscle_weight0.60904730
144MP0005166_decreased_susceptibility_to0.60822514
145MP0005395_other_phenotype0.60558714
146MP0002249_abnormal_larynx_morphology0.60327274
147MP0010771_integument_phenotype0.60309081
148MP0001835_abnormal_antigen_presentation0.59394781
149MP0004264_abnormal_extraembryonic_tissu0.59373565
150MP0002733_abnormal_thermal_nociception0.59165419
151MP0005257_abnormal_intraocular_pressure0.58803015
152MP0002638_abnormal_pupillary_reflex0.58696721
153MP0003638_abnormal_response/metabolism_0.58336431
154MP0001853_heart_inflammation0.57594156
155MP0003183_abnormal_peptide_metabolism0.57051025
156MP0004858_abnormal_nervous_system0.57025634
157MP0008872_abnormal_physiological_respon0.56274955
158MP0001186_pigmentation_phenotype0.53174340
159MP0001348_abnormal_lacrimal_gland0.51224862
160MP0000534_abnormal_ureter_morphology0.50382874
161MP0001324_abnormal_eye_pigmentation0.47718704
162MP0000003_abnormal_adipose_tissue0.47567498
163MP0002095_abnormal_skin_pigmentation0.46013178
164MP0000026_abnormal_inner_ear0.44518303
165MP0000678_abnormal_parathyroid_gland0.43473909
166MP0003632_abnormal_nervous_system0.42297966
167MP0000367_abnormal_coat/_hair0.42232928
168MP0001501_abnormal_sleep_pattern0.40750583
169MP0001963_abnormal_hearing_physiology0.39998194

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)6.50358260
2Ulnar bowing (HP:0003031)6.04589668
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.72657374
4Xanthomatosis (HP:0000991)5.30826414
5Focal motor seizures (HP:0011153)5.17226565
6Intrahepatic cholestasis (HP:0001406)5.07125291
7Testicular atrophy (HP:0000029)5.01162187
8Deep venous thrombosis (HP:0002625)4.91323502
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.89537110
10Rib fusion (HP:0000902)4.53008749
11Annular pancreas (HP:0001734)4.20765514
12Hyperlipoproteinemia (HP:0010980)4.11839330
13Hypobetalipoproteinemia (HP:0003563)4.07218786
14Complement deficiency (HP:0004431)4.04223185
15Prolonged partial thromboplastin time (HP:0003645)3.98768495
16Rectovaginal fistula (HP:0000143)3.95426184
17Rectal fistula (HP:0100590)3.95426184
18Vaginal fistula (HP:0004320)3.93320192
19Rectal prolapse (HP:0002035)3.92048347
20Intestinal fistula (HP:0100819)3.88543797
21Mesangial abnormality (HP:0001966)3.85810999
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.78169368
23Congenital stationary night blindness (HP:0007642)3.70283134
24Systemic lupus erythematosus (HP:0002725)3.65921798
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.53400714
26Attenuation of retinal blood vessels (HP:0007843)3.46885752
27Hyperammonemia (HP:0001987)3.44726463
28Parakeratosis (HP:0001036)3.43074680
29Myocardial infarction (HP:0001658)3.41210754
30Vacuolated lymphocytes (HP:0001922)3.38979986
31Abnormality of complement system (HP:0005339)3.37270204
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.35384349
33Abnormal albumin level (HP:0012116)3.34175589
34Hypoalbuminemia (HP:0003073)3.34175589
35Pendular nystagmus (HP:0012043)3.30051093
36Akinesia (HP:0002304)3.26089591
37Joint hemorrhage (HP:0005261)3.25910772
38Axonal loss (HP:0003447)3.23695689
39Ketosis (HP:0001946)3.22665793
40Facial diplegia (HP:0001349)3.21353912
41Thin bony cortex (HP:0002753)3.20493976
42Hypolipoproteinemia (HP:0010981)3.19256874
43Bowing of the arm (HP:0006488)3.19226856
44Bowed forearm bones (HP:0003956)3.19226856
45Abnormality of the common coagulation pathway (HP:0010990)3.14796395
46Hypercholesterolemia (HP:0003124)3.13102253
47Fat malabsorption (HP:0002630)3.11317983
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.04718147
49Abnormality of sulfur amino acid metabolism (HP:0004339)3.04348298
50Epidermoid cyst (HP:0200040)3.04184505
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04054374
52Poikiloderma (HP:0001029)2.97503067
53Atrioventricular block (HP:0001678)2.94481522
54Hyperglycinemia (HP:0002154)2.93980158
55Recurrent gram-negative bacterial infections (HP:0005420)2.91923466
56Hypoalphalipoproteinemia (HP:0003233)2.91461497
57Malnutrition (HP:0004395)2.86975382
58Coronal craniosynostosis (HP:0004440)2.84078838
59Abnormality of glycine metabolism (HP:0010895)2.83496471
60Abnormality of serine family amino acid metabolism (HP:0010894)2.83496471
61Dyschromatopsia (HP:0007641)2.82953584
62Glomerulonephritis (HP:0000099)2.81907507
63Difficulty walking (HP:0002355)2.81461581
64Late onset (HP:0003584)2.79450922
65Conjugated hyperbilirubinemia (HP:0002908)2.79186322
66Hyperglycinuria (HP:0003108)2.78326661
67Dysostosis multiplex (HP:0000943)2.77517097
68Hypoglycemic coma (HP:0001325)2.68317640
69Aplastic anemia (HP:0001915)2.67632604
70Myopathic facies (HP:0002058)2.60824003
71Amyloidosis (HP:0011034)2.59126578
72Abnormality of fatty-acid metabolism (HP:0004359)2.58515910
73Abnormality of the intrinsic pathway (HP:0010989)2.57958251
74Patellar aplasia (HP:0006443)2.54232498
75Bony spicule pigmentary retinopathy (HP:0007737)2.52904253
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48144530
77Skin nodule (HP:0200036)2.46675109
78Abnormality of the Achilles tendon (HP:0005109)2.45978374
79Ketoacidosis (HP:0001993)2.42794862
80Increased serum ferritin (HP:0003281)2.42425883
81Urinary glycosaminoglycan excretion (HP:0003541)2.41168314
82Mucopolysacchariduria (HP:0008155)2.41168314
83Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40714871
84Aplasia/Hypoplasia of the patella (HP:0006498)2.39174502
85Delayed epiphyseal ossification (HP:0002663)2.38143265
86Abnormality of iron homeostasis (HP:0011031)2.37235143
87Focal seizures (HP:0007359)2.37095082
88Abnormality of transition element cation homeostasis (HP:0011030)2.36967325
89Abnormality of methionine metabolism (HP:0010901)2.35191255
90Ankle clonus (HP:0011448)2.33587311
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33340456
92Facial hemangioma (HP:0000329)2.33300383
93Hyperbilirubinemia (HP:0002904)2.31156576
94Abnormality of purine metabolism (HP:0004352)2.30782265
95Polycythemia (HP:0001901)2.28615377
96Birth length less than 3rd percentile (HP:0003561)2.28346958
97Chorioretinal atrophy (HP:0000533)2.27966967
98Decreased circulating renin level (HP:0003351)2.27776296
99Anteriorly placed anus (HP:0001545)2.26229742
100Choanal stenosis (HP:0000452)2.26029111
101Steatorrhea (HP:0002570)2.25113321
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22717126
103Abnormality of polysaccharide metabolism (HP:0011012)2.22717126
104Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22717126
105Vertebral arch anomaly (HP:0008438)2.21877726
106Eczematoid dermatitis (HP:0000976)2.21526972
107Gingival bleeding (HP:0000225)2.21013995
108Abnormality of the fingertips (HP:0001211)2.18404519
109Widely patent fontanelles and sutures (HP:0004492)2.18297690
110Dialeptic seizures (HP:0011146)2.18218286
111Abnormality of the hepatic vasculature (HP:0006707)2.18121777
112Acanthocytosis (HP:0001927)2.17397134
113Abnormality of nucleobase metabolism (HP:0010932)2.16931949
114Increased neuronal autofluorescent lipopigment (HP:0002074)2.15941945
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14007374
116Upper limb amyotrophy (HP:0009129)2.13742139
117Distal upper limb amyotrophy (HP:0007149)2.13742139
118Neurofibrillary tangles (HP:0002185)2.10296677
119Peritonitis (HP:0002586)2.09842309
120Nephritis (HP:0000123)2.08860721
121Mitral stenosis (HP:0001718)2.08341741
122Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07188913
123Dicarboxylic aciduria (HP:0003215)2.07188913
124Menorrhagia (HP:0000132)2.06909173
125Macular degeneration (HP:0000608)2.06186273
126Brushfield spots (HP:0001088)2.05855861
127Abnormality of the costochondral junction (HP:0000919)2.05628275
128Severe visual impairment (HP:0001141)2.05531756
129Metabolic acidosis (HP:0001942)2.04668696
130Global brain atrophy (HP:0002283)2.03765739
131Achilles tendon contracture (HP:0001771)2.03595829
132Aplasia of the musculature (HP:0100854)2.03223794
133Increased cerebral lipofuscin (HP:0011813)2.02773771
134Hypoplasia of the pons (HP:0012110)2.02702545
135Potter facies (HP:0002009)2.02382239
136Facial shape deformation (HP:0011334)2.02382239
137Esophageal varix (HP:0002040)2.01956272
138Hypophosphatemic rickets (HP:0004912)2.00654070
139Abnormal enzyme/coenzyme activity (HP:0012379)2.00285380
140Type I transferrin isoform profile (HP:0003642)1.99985684
141Abnormality of proline metabolism (HP:0010907)1.99134237
142Hydroxyprolinuria (HP:0003080)1.99134237
143Abnormal gallbladder morphology (HP:0012437)1.98248902
144Neonatal respiratory distress (HP:0002643)1.98016849
145Delayed CNS myelination (HP:0002188)1.96148419
146Irritability (HP:0000737)1.96085502
147Hand muscle atrophy (HP:0009130)1.95700967
148Right ventricular cardiomyopathy (HP:0011663)1.94444963
149Gout (HP:0001997)1.93924884
150Abnormality of macrophages (HP:0004311)1.92474303
151Stridor (HP:0010307)1.92456885
152External ophthalmoplegia (HP:0000544)1.91256937
153Heart block (HP:0012722)1.90932928
154Vascular calcification (HP:0004934)1.90297574
155Pancreatitis (HP:0001733)1.89446566
156Cholelithiasis (HP:0001081)1.89413832
157Abnormality of pyrimidine metabolism (HP:0004353)1.89231318
158Sensorimotor neuropathy (HP:0007141)1.87217456
159Elevated alkaline phosphatase (HP:0003155)1.87035330
160Protuberant abdomen (HP:0001538)1.86866304
161Opisthotonus (HP:0002179)1.86733550
162Cerebral inclusion bodies (HP:0100314)1.86327128
163Carpal synostosis (HP:0009702)1.85487727
164Abnormal atrioventricular conduction (HP:0005150)1.85448846
165Abnormality of alkaline phosphatase activity (HP:0004379)1.84875743
166Hemorrhage of the eye (HP:0011885)1.84829885
167Myotonia (HP:0002486)1.83734923
168Scapular winging (HP:0003691)1.83703557
169Loss of speech (HP:0002371)1.83415566
170Poikilocytosis (HP:0004447)1.83252663
171Popliteal pterygium (HP:0009756)1.82935682
172Urticaria (HP:0001025)1.81512805
173Spontaneous hematomas (HP:0007420)1.80801596
174Hyperinsulinemic hypoglycemia (HP:0000825)1.79849480
175Squamous cell carcinoma (HP:0002860)1.79594756
176Congenital ichthyosiform erythroderma (HP:0007431)1.78747827
177Turricephaly (HP:0000262)1.78222982
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.77434345
179Neonatal onset (HP:0003623)1.77083173
180Ileus (HP:0002595)1.77028387
181Colitis (HP:0002583)1.76765379
182Bronchomalacia (HP:0002780)1.76212386
183Short chin (HP:0000331)1.75389490
184Narrow nasal bridge (HP:0000446)1.75387081
185Fetal akinesia sequence (HP:0001989)1.75277188
186Pustule (HP:0200039)1.74723469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS18.01863568
2LATS25.58267382
3STK38L5.26437724
4ERN15.14059010
5PRKD34.14326038
6TRIB33.42679055
7ZAK2.95698371
8MAP3K102.85128063
9BCKDK2.78735073
10EPHB12.61310436
11STK382.58601659
12FGFR42.57755795
13ACVR1B2.57470964
14TAOK32.53294532
15TBK12.48838922
16BLK2.14249222
17SIK12.09936317
18MAP4K11.99205873
19MAP2K21.97914170
20TYK21.96030911
21MAPK151.88920256
22PKN21.86421458
23ICK1.78755121
24MST1R1.69363642
25PTK61.64378805
26MELK1.60684786
27MAP3K111.58391464
28IKBKE1.52833563
29FLT31.46354703
30GRK61.45118359
31DAPK21.43549106
32TAOK11.40131319
33KIT1.39712244
34IRAK31.34933833
35NLK1.31513594
36PIK3CG1.29433767
37CSK1.25231091
38LMTK21.24379280
39NEK21.17004587
40MAPK111.15802564
41STK101.15737844
42TNK21.11818517
43EEF2K1.11559472
44ZAP701.09666272
45PIM21.09513251
46SMG11.08165635
47WNK41.06134598
48MAP3K31.05917130
49STK31.05833855
50SIK21.04547822
51DYRK1B1.00974380
52LRRK20.97143744
53RIPK10.96257468
54JAK10.95343287
55JAK20.94506029
56BMX0.92697351
57BMPR1B0.90791450
58TESK20.90219457
59PRPF4B0.87469485
60CSF1R0.87293564
61ITK0.86424874
62KSR20.86060392
63MAP3K10.84772843
64BTK0.84374983
65MUSK0.83858566
66NME10.83271796
67DMPK0.82664791
68MST40.81903005
69MAPKAPK30.79315920
70PTK20.77998978
71IKBKB0.75308007
72RIPK40.75062472
73ERBB40.74827625
74ADRBK10.73850240
75TTN0.73800154
76CDK120.73231676
77MET0.72480615
78TLK10.71413009
79NME20.70207763
80HIPK20.67896715
81HCK0.67849937
82MTOR0.66910358
83MAP3K70.64645660
84MAP3K20.64306112
85STK110.62181221
86PRKAA20.62085058
87TGFBR20.61426594
88KDR0.61309495
89* PRKD10.60748367
90CAMK1D0.60016320
91IRAK20.59569421
92FGR0.59019722
93DAPK30.58190225
94PRKCI0.57233742
95LCK0.56433027
96JAK30.55537644
97STK390.54241386
98ARAF0.53618703
99GSK3A0.52249908
100* PDPK10.52234390
101EPHB20.51711393
102ADRBK20.51152420
103ABL20.51104587
104MARK20.50223329
105MAP3K130.50179118
106SYK0.49985584
107EPHA40.49818756
108MAPK40.49796956
109MAP2K30.48277914
110IRAK40.48095895
111MATK0.47392786
112PRKD20.45065485
113PAK40.44972136
114MAPKAPK20.44774103
115PDK10.43943405
116PKN10.43924207
117EPHA20.43267797
118MAP3K80.43104758
119CDK40.42705862
120CSNK1A1L0.42380356
121AKT20.42297136
122GRK50.40981889
123MAP2K10.40917076
124SIK30.38409643
125PRKCH0.38144599
126PAK60.37946036
127ERBB20.37303271
128OXSR10.37026579
129PRKG20.36555837
130BRAF0.36502967
131FRK0.36329127
132PAK20.36108192
133DAPK10.35909904
134EGFR0.35301990
135RPS6KA10.34898057
136PRKACG0.33782337
137PRKCZ0.33729062
138RPS6KA40.33525284
139WNK10.32959824
140MAPK80.32433275
141NTRK30.31415005
142TYRO30.31196664
143RPS6KA20.30638398
144TAF10.29291264
145CHEK20.27464697
146AURKA0.27273980
147PINK10.25478156
148CAMKK10.25148927
149CDK50.24715493
150MAP2K60.24041055
151CDK190.23403111
152CSNK1D0.20142530
153CAMK2B0.18317589
154RPS6KA60.17728176
155PAK10.17631680
156RPS6KL10.17568918
157RPS6KC10.17568918
158MAPK120.16882940
159CDK11A0.16380015
160CDK150.16156180
161CDC42BPA0.12993691

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.58749389
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.42417272
3Nitrogen metabolism_Homo sapiens_hsa009103.08292478
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94167749
5Nicotine addiction_Homo sapiens_hsa050332.79753038
6Arginine biosynthesis_Homo sapiens_hsa002202.66742013
7Phototransduction_Homo sapiens_hsa047442.51306980
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50783878
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.50199870
10Fatty acid degradation_Homo sapiens_hsa000712.41871041
11Complement and coagulation cascades_Homo sapiens_hsa046102.41005892
12Tryptophan metabolism_Homo sapiens_hsa003802.39988959
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.39921743
14Staphylococcus aureus infection_Homo sapiens_hsa051502.38808030
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.32197647
16Histidine metabolism_Homo sapiens_hsa003402.26889595
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25392435
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17994174
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17514659
20Taste transduction_Homo sapiens_hsa047422.01760552
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98576758
22Folate biosynthesis_Homo sapiens_hsa007901.91877583
23Steroid biosynthesis_Homo sapiens_hsa001001.89414566
24Fat digestion and absorption_Homo sapiens_hsa049751.88255108
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.84483673
26Peroxisome_Homo sapiens_hsa041461.82213398
27PPAR signaling pathway_Homo sapiens_hsa033201.77164033
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74623823
29N-Glycan biosynthesis_Homo sapiens_hsa005101.73299564
30Caffeine metabolism_Homo sapiens_hsa002321.70979950
31Fatty acid metabolism_Homo sapiens_hsa012121.68550579
32Sulfur metabolism_Homo sapiens_hsa009201.66054386
33Butanoate metabolism_Homo sapiens_hsa006501.63060776
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59671817
35Fatty acid elongation_Homo sapiens_hsa000621.55257096
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.52831985
37Chemical carcinogenesis_Homo sapiens_hsa052041.50552226
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50278209
39Sulfur relay system_Homo sapiens_hsa041221.45729442
40Morphine addiction_Homo sapiens_hsa050321.40983199
41beta-Alanine metabolism_Homo sapiens_hsa004101.40372060
42Propanoate metabolism_Homo sapiens_hsa006401.38633887
43Selenocompound metabolism_Homo sapiens_hsa004501.36205090
44Bile secretion_Homo sapiens_hsa049761.35567314
45ABC transporters_Homo sapiens_hsa020101.33567694
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33005929
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.22343763
48Phenylalanine metabolism_Homo sapiens_hsa003601.21722075
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21285551
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15501563
51Retinol metabolism_Homo sapiens_hsa008301.15383010
52Dorso-ventral axis formation_Homo sapiens_hsa043201.15165056
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.13825914
54Starch and sucrose metabolism_Homo sapiens_hsa005001.13605164
55GABAergic synapse_Homo sapiens_hsa047271.12899490
56Pyruvate metabolism_Homo sapiens_hsa006201.11930368
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05197169
58Arginine and proline metabolism_Homo sapiens_hsa003301.05000543
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03375618
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01618602
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00333508
62Tyrosine metabolism_Homo sapiens_hsa003500.99374218
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98324836
64Vitamin digestion and absorption_Homo sapiens_hsa049770.96407565
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94188702
66Lysine degradation_Homo sapiens_hsa003100.93241973
67Carbon metabolism_Homo sapiens_hsa012000.91554267
68Other glycan degradation_Homo sapiens_hsa005110.91014813
69Glutamatergic synapse_Homo sapiens_hsa047240.90815318
70Lysosome_Homo sapiens_hsa041420.89059454
71Glycerolipid metabolism_Homo sapiens_hsa005610.87236011
72Biosynthesis of amino acids_Homo sapiens_hsa012300.86097808
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84022386
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82812825
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76675770
76Synaptic vesicle cycle_Homo sapiens_hsa047210.74695672
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73975774
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.73849311
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72160429
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.71864643
81Pentose phosphate pathway_Homo sapiens_hsa000300.70234658
82Ovarian steroidogenesis_Homo sapiens_hsa049130.69389232
83* Calcium signaling pathway_Homo sapiens_hsa040200.69235942
84Glutathione metabolism_Homo sapiens_hsa004800.68778520
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63978149
86Melanogenesis_Homo sapiens_hsa049160.62281177
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62195120
88Linoleic acid metabolism_Homo sapiens_hsa005910.61101265
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60748670
90Hippo signaling pathway_Homo sapiens_hsa043900.58559521
91Insulin secretion_Homo sapiens_hsa049110.57159805
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.56562819
93Insulin resistance_Homo sapiens_hsa049310.53901057
94Prion diseases_Homo sapiens_hsa050200.53467686
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52809189
96Hedgehog signaling pathway_Homo sapiens_hsa043400.52558998
97Fatty acid biosynthesis_Homo sapiens_hsa000610.50984881
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50880797
99cAMP signaling pathway_Homo sapiens_hsa040240.49996703
100Pertussis_Homo sapiens_hsa051330.48429948
101Galactose metabolism_Homo sapiens_hsa000520.48239961
102Vitamin B6 metabolism_Homo sapiens_hsa007500.47006688
103Inositol phosphate metabolism_Homo sapiens_hsa005620.46528340
104Cholinergic synapse_Homo sapiens_hsa047250.45459434
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43433712
106Mineral absorption_Homo sapiens_hsa049780.43099247
107Basal cell carcinoma_Homo sapiens_hsa052170.41826671
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41287182
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40424954
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40183950
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.40030098
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39665630
113Circadian entrainment_Homo sapiens_hsa047130.38520997
114Fructose and mannose metabolism_Homo sapiens_hsa000510.37116669
115Cocaine addiction_Homo sapiens_hsa050300.37050766
116One carbon pool by folate_Homo sapiens_hsa006700.36753770
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36546225
118Gastric acid secretion_Homo sapiens_hsa049710.36088276
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35929503
120Thyroid hormone synthesis_Homo sapiens_hsa049180.35722367
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35080736
122Acute myeloid leukemia_Homo sapiens_hsa052210.34284011
123Osteoclast differentiation_Homo sapiens_hsa043800.33263932
124* Metabolic pathways_Homo sapiens_hsa011000.32992949
125Leishmaniasis_Homo sapiens_hsa051400.32723837
126Serotonergic synapse_Homo sapiens_hsa047260.31153984
127Fanconi anemia pathway_Homo sapiens_hsa034600.30644574
128Hepatitis C_Homo sapiens_hsa051600.30537950
129Renin-angiotensin system_Homo sapiens_hsa046140.28899646
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27234909
131Bladder cancer_Homo sapiens_hsa052190.26968388
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25747624
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23206892
134Long-term potentiation_Homo sapiens_hsa047200.22145749
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.21917283
136Estrogen signaling pathway_Homo sapiens_hsa049150.21807785
137Notch signaling pathway_Homo sapiens_hsa043300.20552749
138Salivary secretion_Homo sapiens_hsa049700.19570757
139B cell receptor signaling pathway_Homo sapiens_hsa046620.19560803
140Amoebiasis_Homo sapiens_hsa051460.18819131
141* Sphingolipid metabolism_Homo sapiens_hsa006000.17078937
142Legionellosis_Homo sapiens_hsa051340.16867940
143AMPK signaling pathway_Homo sapiens_hsa041520.15183905
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13071834
145Ether lipid metabolism_Homo sapiens_hsa005650.10177243
146* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10082166

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »