SPG11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.85769233
2phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.37238806
3nuclear pore complex assembly (GO:0051292)4.28351648
4B cell receptor signaling pathway (GO:0050853)4.04842424
5cytoplasmic mRNA processing body assembly (GO:0033962)3.99031016
6cellular extravasation (GO:0045123)3.87769865
7detection of molecule of bacterial origin (GO:0032490)3.87167167
8cellular response to ethanol (GO:0071361)3.85885434
9nuclear pore organization (GO:0006999)3.85181739
10negative thymic T cell selection (GO:0045060)3.69217104
11positive regulation of granulocyte differentiation (GO:0030854)3.65735140
12negative T cell selection (GO:0043383)3.64043925
13detection of other organism (GO:0098543)3.58053448
14pre-miRNA processing (GO:0031054)3.57742063
15NLS-bearing protein import into nucleus (GO:0006607)3.53082354
16macrophage activation involved in immune response (GO:0002281)3.53006383
17positive regulation of histone deacetylation (GO:0031065)3.50920544
18regulation of protein polyubiquitination (GO:1902914)3.44092208
19negative regulation of lymphocyte mediated immunity (GO:0002707)3.41365694
20detection of external biotic stimulus (GO:0098581)3.40374293
21regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.38987717
22histone H3-K4 trimethylation (GO:0080182)3.38078135
23microglial cell activation (GO:0001774)3.37421304
24negative regulation of T cell mediated immunity (GO:0002710)3.34476645
25positive T cell selection (GO:0043368)3.32515549
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31008292
27response to interleukin-15 (GO:0070672)3.29303738
28mitotic sister chromatid cohesion (GO:0007064)3.23978017
29pore complex assembly (GO:0046931)3.22870805
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22547884
31detection of bacterium (GO:0016045)3.21761354
32positive thymic T cell selection (GO:0045059)3.19707386
33macroautophagy (GO:0016236)3.15470055
34apoptotic cell clearance (GO:0043277)3.14491592
35positive regulation of B cell differentiation (GO:0045579)3.13479078
36regulation of B cell differentiation (GO:0045577)3.02615847
37hepatocyte apoptotic process (GO:0097284)3.00348089
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99882162
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99882162
40T cell selection (GO:0045058)2.99765846
41activated T cell proliferation (GO:0050798)2.99673963
42peptidyl-lysine dimethylation (GO:0018027)2.97990005
43regulation of translational fidelity (GO:0006450)2.97747183
44interkinetic nuclear migration (GO:0022027)2.97090739
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96882898
46growth hormone receptor signaling pathway (GO:0060396)2.96506041
47regulation of RNA export from nucleus (GO:0046831)2.93693505
48phospholipid homeostasis (GO:0055091)2.93419533
49histone H3-K36 demethylation (GO:0070544)2.91502019
50macrophage activation (GO:0042116)2.90539373
51negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.90491387
52cellular response to interleukin-15 (GO:0071350)2.87992031
53neutrophil mediated immunity (GO:0002446)2.87739153
54mannose metabolic process (GO:0006013)2.87659026
55insulin-like growth factor receptor signaling pathway (GO:0048009)2.87645459
56positive regulation of SMAD protein import into nucleus (GO:0060391)2.86229122
57detection of biotic stimulus (GO:0009595)2.85806766
58negative regulation of histone methylation (GO:0031061)2.85663517
59positive regulation of p38MAPK cascade (GO:1900745)2.85117397
60positive regulation of gamma-delta T cell activation (GO:0046645)2.84488506
61monoubiquitinated protein deubiquitination (GO:0035520)2.83581720
62histone H3-K9 demethylation (GO:0033169)2.83144524
63response to muramyl dipeptide (GO:0032495)2.82087735
64positive regulation of interferon-alpha production (GO:0032727)2.81446163
65neutrophil activation involved in immune response (GO:0002283)2.81343642
66positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80430311
67negative regulation of adaptive immune response (GO:0002820)2.78614980
68establishment of protein localization to Golgi (GO:0072600)2.77767791
69regulation of necroptotic process (GO:0060544)2.74785318
70negative regulation of leukocyte mediated immunity (GO:0002704)2.74481796
71antigen processing and presentation via MHC class Ib (GO:0002475)2.73571581
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73336647
73regulation of tolerance induction (GO:0002643)2.72742961
74iron ion import (GO:0097286)2.71817072
75histone lysine demethylation (GO:0070076)2.69391682
76production of molecular mediator involved in inflammatory response (GO:0002532)2.69374608
77negative regulation of B cell mediated immunity (GO:0002713)2.69342961
78negative regulation of immunoglobulin mediated immune response (GO:0002890)2.69342961
79germinal center formation (GO:0002467)2.69085978
80T cell migration (GO:0072678)2.69073697
81heterochromatin organization (GO:0070828)2.68733441
82antigen processing and presentation of endogenous antigen (GO:0019883)2.68638670
83low-density lipoprotein particle clearance (GO:0034383)2.68618724
84response to host immune response (GO:0052572)2.68047388
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68047388
86cell adhesion mediated by integrin (GO:0033627)2.67259919
87glucocorticoid receptor signaling pathway (GO:0042921)2.65859495
88peptidyl-lysine trimethylation (GO:0018023)2.65732673
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64637314
90response to host (GO:0075136)2.64637314
91response to host defenses (GO:0052200)2.64637314
92response to peptidoglycan (GO:0032494)2.64459404
93regulation of alpha-beta T cell proliferation (GO:0046640)2.64315829
94regulation of histone H3-K9 methylation (GO:0051570)2.63861081
95interferon-gamma production (GO:0032609)2.63598151
96dendritic cell migration (GO:0036336)2.63556687
97myeloid leukocyte mediated immunity (GO:0002444)2.61967447
98regulation of nucleobase-containing compound transport (GO:0032239)2.61398600
99response to type I interferon (GO:0034340)2.61047893
100thymic T cell selection (GO:0045061)2.60960569
101regulation of granulocyte differentiation (GO:0030852)2.60810275
102protein targeting to Golgi (GO:0000042)2.59961426
103positive regulation of tolerance induction (GO:0002645)2.59609589
104negative regulation of B cell proliferation (GO:0030889)2.59566041
105negative regulation of T-helper cell differentiation (GO:0045623)2.58820659
106negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.58820659
107positive regulation of cellular amide metabolic process (GO:0034250)2.58145842
108regulation of interferon-beta biosynthetic process (GO:0045357)2.57954916
109regulation of fatty acid beta-oxidation (GO:0031998)2.57096028
110cellular response to type I interferon (GO:0071357)2.56684393
111type I interferon signaling pathway (GO:0060337)2.56684393
112definitive hemopoiesis (GO:0060216)2.56668838
113regulation of interferon-alpha production (GO:0032647)2.56204116
114negative regulation of interleukin-12 production (GO:0032695)2.56193780
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.55756373
116myeloid cell activation involved in immune response (GO:0002275)2.55691360
117regulation of interleukin-12 biosynthetic process (GO:0045075)2.55365142
118L-alpha-amino acid transmembrane transport (GO:1902475)2.54857390
119retrograde transport, vesicle recycling within Golgi (GO:0000301)2.54809515
120positive regulation of fatty acid beta-oxidation (GO:0032000)2.54269003
121response to laminar fluid shear stress (GO:0034616)2.52987798
122activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52010609
123regulation of gamma-delta T cell differentiation (GO:0045586)2.51407519
124histone demethylation (GO:0016577)2.50115695
125regulation of NFAT protein import into nucleus (GO:0051532)2.49399103
126epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49309162
127regulation of mitotic spindle organization (GO:0060236)2.49173534
128cellular response to growth hormone stimulus (GO:0071378)2.49009453
129I-kappaB phosphorylation (GO:0007252)2.48557550
130regulation of translation, ncRNA-mediated (GO:0045974)2.47937089
131negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47937089
132negative regulation of translation, ncRNA-mediated (GO:0040033)2.47937089
133response to UV-C (GO:0010225)2.47871925
134regulation of cholesterol storage (GO:0010885)2.47500018
135positive regulation of nuclease activity (GO:0032075)2.42769533
136regulation of SMAD protein import into nucleus (GO:0060390)2.39068890
137vascular endothelial growth factor signaling pathway (GO:0038084)2.38178181
138corticosteroid receptor signaling pathway (GO:0031958)2.37912865
139chromatin assembly (GO:0031497)2.37513379
140regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.35734794
141hippo signaling (GO:0035329)2.34904415
142regulation of gamma-delta T cell activation (GO:0046643)2.34482553
143negative regulation of cell killing (GO:0031342)2.34390493
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.34390493
145embryonic placenta development (GO:0001892)2.34149104
146positive regulation by symbiont of host defense response (GO:0052509)2.30971642
147modulation by symbiont of host defense response (GO:0052031)2.30971642
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30971642
149modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30971642
150positive regulation by organism of defense response of other organism involved in symbiotic interact2.30971642
151modulation by symbiont of host immune response (GO:0052553)2.30971642
152regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.30935894
153regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29820383
154folic acid-containing compound biosynthetic process (GO:0009396)2.29462046
155mRNA stabilization (GO:0048255)2.29359518
156RNA stabilization (GO:0043489)2.29359518
157mitotic chromosome condensation (GO:0007076)2.29346782
158regulation of integrin activation (GO:0033623)2.29318002
159positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28703060
160dosage compensation (GO:0007549)2.28315929
161regulation of nuclease activity (GO:0032069)2.27304597
162COPI coating of Golgi vesicle (GO:0048205)2.27131185
163Golgi transport vesicle coating (GO:0048200)2.27131185
164germ cell migration (GO:0008354)2.26265727
165histone mRNA catabolic process (GO:0071044)2.26159756
166negative regulation of granulocyte differentiation (GO:0030853)2.26063442
167regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.24055965
168regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.22487676
169protein dealkylation (GO:0008214)2.21860582
170protein demethylation (GO:0006482)2.21860582
171endoplasmic reticulum unfolded protein response (GO:0030968)2.21611896
172cortical actin cytoskeleton organization (GO:0030866)2.19638104
173determination of adult lifespan (GO:0008340)2.19592772
174regulation of sister chromatid cohesion (GO:0007063)2.19287429
175negative regulation of fatty acid transport (GO:2000192)2.18956084
176alpha-linolenic acid metabolic process (GO:0036109)2.18480187
177embryonic retina morphogenesis in camera-type eye (GO:0060059)2.17554249
178histone H2A monoubiquitination (GO:0035518)2.16824130
179DNA geometric change (GO:0032392)2.16591619
180negative regulation of DNA repair (GO:0045738)2.16306769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.94577092
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.45763653
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.36602642
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.53331279
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.13103985
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13043419
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.00076629
8MYC_22102868_ChIP-Seq_BL_Human2.47518763
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40298618
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.30396662
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28535970
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.14041625
13TCF7_22412390_ChIP-Seq_EML_Mouse1.99544292
14CLOCK_20551151_ChIP-Seq_293T_Human1.95294603
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91931390
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88372842
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87857879
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86936714
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81466865
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80011738
21VDR_24787735_ChIP-Seq_THP-1_Human1.73961318
22KDM2B_26808549_Chip-Seq_DND41_Human1.70055923
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.66460561
24* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66079506
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.64582811
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64068592
27GATA1_22025678_ChIP-Seq_K562_Human1.63665095
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63409845
29GATA3_27048872_Chip-Seq_THYMUS_Human1.62983605
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62620016
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.61959432
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61027007
33VDR_21846776_ChIP-Seq_THP-1_Human1.57760899
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57321337
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.55337602
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54354604
37* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49771346
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47724337
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.47376619
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46821413
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45871421
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45539742
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.43763229
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43525244
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.43232356
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42382812
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42345468
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39544005
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39434328
50MAF_26560356_Chip-Seq_TH1_Human1.39409347
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38488179
52SPI1_23547873_ChIP-Seq_NB4_Human1.38147139
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36882789
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36783152
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36196667
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35604208
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34461274
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34301766
59* FOXA2_19822575_ChIP-Seq_HepG2_Human1.34263517
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.30931829
61UTX_26944678_Chip-Seq_JUKART_Human1.30920926
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30278924
63GATA2_19941826_ChIP-Seq_K562_Human1.30136352
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29713019
65TP53_16413492_ChIP-PET_HCT116_Human1.29593810
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28504407
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28311445
68RUNX_20019798_ChIP-Seq_JUKART_Human1.27103490
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27014085
70MYB_26560356_Chip-Seq_TH1_Human1.26055020
71* GATA3_26560356_Chip-Seq_TH2_Human1.25905344
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25397327
73TFEB_21752829_ChIP-Seq_HELA_Human1.24199303
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23799985
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23750806
76GATA6_25053715_ChIP-Seq_YYC3_Human1.23590795
77GATA1_19941826_ChIP-Seq_K562_Human1.23466144
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22210061
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22001256
80BRD4_25478319_ChIP-Seq_HGPS_Human1.20784182
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20413709
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20042440
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19756656
84AHR_22903824_ChIP-Seq_MCF-7_Human1.19354853
85SPI1_23127762_ChIP-Seq_K562_Human1.19001007
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18861349
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18765145
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18545569
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18356168
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17339911
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16710446
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16466410
93PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15177778
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15075585
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.14899626
96* MYB_26560356_Chip-Seq_TH2_Human1.13694454
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13166742
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13152481
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.12877232
100PU_27001747_Chip-Seq_BMDM_Mouse1.12845208
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.12824701
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.12004321
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11635951
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11573330
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11573330
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10874117
107NCOR1_26117541_ChIP-Seq_K562_Human1.09481480
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09349733
109ER_23166858_ChIP-Seq_MCF-7_Human1.08437655
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.07741792
111ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07496660
112GATA1_19941827_ChIP-Seq_MEL_Mouse1.07177928
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06991865
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06921140
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06913144
116NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06870446
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.05800219
118AR_21909140_ChIP-Seq_LNCAP_Human1.05538536
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05405620
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05221254
121SMRT_27268052_Chip-Seq_Bcells_Human1.03617396
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03559102
123STAT3_23295773_ChIP-Seq_U87_Human1.02684163
124VDR_24763502_ChIP-Seq_THP-1_Human1.02400566
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01766473
126STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01425270
127SCL_19346495_ChIP-Seq_HPC-7_Human0.99242534
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98633517
129AR_21572438_ChIP-Seq_LNCaP_Human0.98397476
130* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98271185
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98143437
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96406337
133FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96406008
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95234291
135EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94935735
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94756849
137RUNX1_22412390_ChIP-Seq_EML_Mouse0.94450066
138* TP63_23658742_ChIP-Seq_EP156T_Human0.94384796
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93242849
140ATF3_27146783_Chip-Seq_COLON_Human0.92626907
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.92030462
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91695266
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.91245188
144* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91243487
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91107291
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89964877
147TCF4_23295773_ChIP-Seq_U87_Human0.88676133
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88501765
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.88414227
150TCF4_18268006_ChIP-ChIP_LS174T_Human0.87841245
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.87241025
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86704855
153GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85136042
154VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84626717
155CDX2_22108803_ChIP-Seq_LS180_Human0.84413912
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84268465
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84107453
158RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83884171
159FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83552789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.94907566
2MP0003705_abnormal_hypodermis_morpholog3.97286807
3MP0003724_increased_susceptibility_to3.38086662
4MP0010352_gastrointestinal_tract_polyps3.16446898
5MP0003300_gastrointestinal_ulcer2.99885042
6MP0003763_abnormal_thymus_physiology2.96787448
7MP0005076_abnormal_cell_differentiation2.92924887
8MP0010307_abnormal_tumor_latency2.42263565
9MP0002166_altered_tumor_susceptibility2.33133336
10MP0003436_decreased_susceptibility_to2.29341225
11MP0004381_abnormal_hair_follicle2.18849370
12MP0005451_abnormal_body_composition2.17410634
13MP0002419_abnormal_innate_immunity2.13243488
14MP0008438_abnormal_cutaneous_collagen2.10205489
15MP0003566_abnormal_cell_adhesion2.08250116
16MP0002877_abnormal_melanocyte_morpholog2.05964385
17MP0010234_abnormal_vibrissa_follicle2.04181185
18MP0002723_abnormal_immune_serum2.02972589
19MP0005671_abnormal_response_to1.96635530
20MP0005025_abnormal_response_to1.94987465
21MP0005000_abnormal_immune_tolerance1.93559316
22MP0002420_abnormal_adaptive_immunity1.92750742
23MP0009278_abnormal_bone_marrow1.92187320
24MP0001819_abnormal_immune_cell1.91069756
25MP0003656_abnormal_erythrocyte_physiolo1.88062415
26MP0000015_abnormal_ear_pigmentation1.87883073
27MP0000371_diluted_coat_color1.85029997
28MP0005310_abnormal_salivary_gland1.84578276
29MP0003172_abnormal_lysosome_physiology1.79151974
30MP0010155_abnormal_intestine_physiology1.77070693
31MP0003252_abnormal_bile_duct1.74158659
32MP0004883_abnormal_blood_vessel1.72639222
33MP0003866_abnormal_defecation1.69763990
34MP0009785_altered_susceptibility_to1.67677924
35MP0003091_abnormal_cell_migration1.67426446
36MP0003828_pulmonary_edema1.67166242
37MP0005075_abnormal_melanosome_morpholog1.63792682
38MP0002405_respiratory_system_inflammati1.63440161
39MP0002006_tumorigenesis1.61978532
40MP0005464_abnormal_platelet_physiology1.58981362
41MP0003045_fibrosis1.58908268
42MP0000716_abnormal_immune_system1.57110818
43MP0004185_abnormal_adipocyte_glucose1.51976329
44MP0008260_abnormal_autophagy1.51647316
45MP0005058_abnormal_lysosome_morphology1.50918296
46MP0000465_gastrointestinal_hemorrhage1.48787688
47MP0000733_abnormal_muscle_development1.48587516
48MP0000689_abnormal_spleen_morphology1.47534849
49MP0005023_abnormal_wound_healing1.45596536
50MP0003183_abnormal_peptide_metabolism1.44237457
51MP0005360_urolithiasis1.43083068
52MP0005257_abnormal_intraocular_pressure1.42730592
53MP0002722_abnormal_immune_system1.39641479
54MP0000703_abnormal_thymus_morphology1.37340972
55MP0006082_CNS_inflammation1.34828447
56MP0001845_abnormal_inflammatory_respons1.32598940
57MP0002254_reproductive_system_inflammat1.31510984
58MP0004197_abnormal_fetal_growth/weight/1.30455814
59MP0002139_abnormal_hepatobiliary_system1.29873042
60MP0003303_peritoneal_inflammation1.29628598
61MP0004947_skin_inflammation1.29136172
62MP0002396_abnormal_hematopoietic_system1.27647137
63MP0004808_abnormal_hematopoietic_stem1.26953402
64MP0004484_altered_response_of1.25199077
65MP0001851_eye_inflammation1.23843173
66MP0003690_abnormal_glial_cell1.21867624
67MP0005365_abnormal_bile_salt1.21223659
68MP0009840_abnormal_foam_cell1.19940504
69MP0002429_abnormal_blood_cell1.18910575
70MP0005666_abnormal_adipose_tissue1.18829165
71MP0003453_abnormal_keratinocyte_physiol1.16711078
72MP0002086_abnormal_extraembryonic_tissu1.15987421
73MP0001958_emphysema1.15494656
74MP0001915_intracranial_hemorrhage1.14020930
75MP0002148_abnormal_hypersensitivity_rea1.09893175
76MP0005409_darkened_coat_color1.09178456
77MP0002088_abnormal_embryonic_growth/wei1.09089092
78MP0001873_stomach_inflammation1.08159103
79MP0001533_abnormal_skeleton_physiology1.07518521
80MP0003984_embryonic_growth_retardation1.07454767
81MP0000427_abnormal_hair_cycle1.06330696
82MP0005164_abnormal_response_to1.05892606
83MP0004264_abnormal_extraembryonic_tissu1.05228421
84MP0001672_abnormal_embryogenesis/_devel1.03965278
85MP0005380_embryogenesis_phenotype1.03965278
86MP0001730_embryonic_growth_arrest1.02163283
87MP0003191_abnormal_cellular_cholesterol1.01690782
88MP0000350_abnormal_cell_proliferation1.01644287
89MP0002928_abnormal_bile_duct1.00244459
90MP0003221_abnormal_cardiomyocyte_apopto1.00230290
91MP0009703_decreased_birth_body1.00088960
92MP0000609_abnormal_liver_physiology0.99555872
93MP0005670_abnormal_white_adipose0.98921228
94MP0003111_abnormal_nucleus_morphology0.97624026
95MP0008961_abnormal_basal_metabolism0.95239559
96MP0005375_adipose_tissue_phenotype0.95208227
97MP0001545_abnormal_hematopoietic_system0.95079151
98MP0005397_hematopoietic_system_phenotyp0.95079151
99MP0000767_abnormal_smooth_muscle0.93858129
100MP0008469_abnormal_protein_level0.93407833
101MP0009672_abnormal_birth_weight0.92173785
102MP0002132_abnormal_respiratory_system0.92047417
103MP0002925_abnormal_cardiovascular_devel0.91564825
104MP0002084_abnormal_developmental_patter0.91548537
105MP0009115_abnormal_fat_cell0.91292312
106MP0002092_abnormal_eye_morphology0.90325132
107MP0000383_abnormal_hair_follicle0.90219699
108MP0000685_abnormal_immune_system0.90206073
109MP0002009_preneoplasia0.90029511
110MP0002168_other_aberrant_phenotype0.89847195
111MP0002697_abnormal_eye_size0.89429025
112MP0002998_abnormal_bone_remodeling0.89427023
113MP0010329_abnormal_lipoprotein_level0.89409361
114MP0003077_abnormal_cell_cycle0.88808937
115MP0005275_abnormal_skin_tensile0.88043149
116MP0001849_ear_inflammation0.87640394
117MP0005623_abnormal_meninges_morphology0.87564053
118MP0004130_abnormal_muscle_cell0.86623639
119MP0001800_abnormal_humoral_immune0.85181065
120MP0001835_abnormal_antigen_presentation0.84736217
121MP0010094_abnormal_chromosome_stability0.84623910
122MP0005621_abnormal_cell_physiology0.84211641
123MP0010630_abnormal_cardiac_muscle0.83719003
124MP0005174_abnormal_tail_pigmentation0.83687965
125MP0010678_abnormal_skin_adnexa0.83337762
126MP0003448_altered_tumor_morphology0.83321511
127MP0003115_abnormal_respiratory_system0.81584313
128MP0008057_abnormal_DNA_replication0.80728600
129MP0000003_abnormal_adipose_tissue0.78798576
130MP0000598_abnormal_liver_morphology0.78762059
131MP0002138_abnormal_hepatobiliary_system0.78343291
132MP0002060_abnormal_skin_morphology0.78207356
133MP0000249_abnormal_blood_vessel0.77944534
134MP0002452_abnormal_antigen_presenting0.76427479
135MP0002075_abnormal_coat/hair_pigmentati0.76364953
136MP0009053_abnormal_anal_canal0.75900052
137MP0005387_immune_system_phenotype0.75599212
138MP0001790_abnormal_immune_system0.75599212
139MP0005083_abnormal_biliary_tract0.75181233
140MP0001697_abnormal_embryo_size0.75156154
141MP0004510_myositis0.75077498
142MP0008004_abnormal_stomach_pH0.74660958
143MP0003279_aneurysm0.74166595
144MP0004043_abnormal_pH_regulation0.73992957
145MP0002080_prenatal_lethality0.72463925
146MP0000858_altered_metastatic_potential0.70944000
147MP0002332_abnormal_exercise_endurance0.70241077
148MP0002085_abnormal_embryonic_tissue0.69141146
149MP0002398_abnormal_bone_marrow0.69116322
150MP0000537_abnormal_urethra_morphology0.68813047
151MP0009763_increased_sensitivity_to0.68740121
152MP0005408_hypopigmentation0.68592499
153MP0009764_decreased_sensitivity_to0.67622157
154MP0002971_abnormal_brown_adipose0.66175209
155MP0006054_spinal_hemorrhage0.63274408
156MP0003787_abnormal_imprinting0.62378006
157MP0002136_abnormal_kidney_physiology0.60455347
158MP0005085_abnormal_gallbladder_physiolo0.59816023
159MP0003943_abnormal_hepatobiliary_system0.59512832

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.62521976
2Recurrent bacterial skin infections (HP:0005406)4.39555271
3Recurrent abscess formation (HP:0002722)3.91862965
4T lymphocytopenia (HP:0005403)3.85306579
5Abnormality of T cell number (HP:0011839)3.68332502
6Cerebral aneurysm (HP:0004944)3.67070825
7Gastrointestinal infarctions (HP:0005244)3.58636432
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.47789697
9Recurrent fungal infections (HP:0002841)3.45956472
10Spontaneous hematomas (HP:0007420)3.39662381
11Myositis (HP:0100614)3.36611896
12Optic neuritis (HP:0100653)3.35337356
13Retrobulbar optic neuritis (HP:0100654)3.35337356
14Chronic mucocutaneous candidiasis (HP:0002728)3.30869133
15Recurrent cutaneous fungal infections (HP:0011370)3.30869133
16Orchitis (HP:0100796)3.16818224
17Recurrent gram-negative bacterial infections (HP:0005420)3.14590206
18Abnormality of the fingertips (HP:0001211)3.14519270
19Gingivitis (HP:0000230)3.10754206
20Recurrent skin infections (HP:0001581)3.09349449
21Macroorchidism (HP:0000053)2.98255922
22Recurrent bronchitis (HP:0002837)2.84487748
23Gingival bleeding (HP:0000225)2.78568284
24Papillary thyroid carcinoma (HP:0002895)2.76493262
25Hematochezia (HP:0002573)2.75647441
26Aortic aneurysm (HP:0004942)2.71437451
27Subacute progressive viral hepatitis (HP:0006572)2.69548811
28Chronic diarrhea (HP:0002028)2.68563260
29Inflammation of the large intestine (HP:0002037)2.68297373
30Vasculitis (HP:0002633)2.68188430
31Abnormality of macrophages (HP:0004311)2.65850904
32Meningitis (HP:0001287)2.63187966
33Heterotopia (HP:0002282)2.63085226
34Chest pain (HP:0100749)2.60963653
35Arterial thrombosis (HP:0004420)2.58657976
36Keratoconjunctivitis sicca (HP:0001097)2.57925084
37Hemoptysis (HP:0002105)2.55742227
38Urethral obstruction (HP:0000796)2.53643379
39Abnormality of T cells (HP:0002843)2.52959534
40Myocardial infarction (HP:0001658)2.49743142
41Gastrointestinal inflammation (HP:0004386)2.47285408
42Aneurysm (HP:0002617)2.44036024
43Shallow orbits (HP:0000586)2.43683987
44Short 4th metacarpal (HP:0010044)2.42789242
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42789242
46Mediastinal lymphadenopathy (HP:0100721)2.42751703
47Abnormality of the astrocytes (HP:0100707)2.41077223
48Astrocytoma (HP:0009592)2.41077223
49Prolonged bleeding time (HP:0003010)2.40902517
50Stomatitis (HP:0010280)2.38402812
51Autoimmune hemolytic anemia (HP:0001890)2.37348528
52Acute myeloid leukemia (HP:0004808)2.35293281
53Keratoconjunctivitis (HP:0001096)2.35161354
54Encephalitis (HP:0002383)2.33931400
55Narrow palate (HP:0000189)2.33072131
56Hyperacusis (HP:0010780)2.32242234
57Ependymoma (HP:0002888)2.29357438
58Mitral valve prolapse (HP:0001634)2.25741942
59Pustule (HP:0200039)2.25441009
60Elevated erythrocyte sedimentation rate (HP:0003565)2.25008870
61Cortical dysplasia (HP:0002539)2.22487037
62Absent frontal sinuses (HP:0002688)2.19409867
63Ankle contracture (HP:0006466)2.16962411
64Stomach cancer (HP:0012126)2.16751498
65Pulmonary infiltrates (HP:0002113)2.16706337
66Osteolytic defects of the hand bones (HP:0009699)2.14864003
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.14864003
68Leukocytosis (HP:0001974)2.14366570
69Pulmonary embolism (HP:0002204)2.13626927
70Epistaxis (HP:0000421)2.12869396
71Panhypogammaglobulinemia (HP:0003139)2.09617115
72Cellulitis (HP:0100658)2.06777402
73Chronic otitis media (HP:0000389)2.06104332
74Ulnar bowing (HP:0003031)2.05964676
75Hyperkalemia (HP:0002153)2.05360870
76Volvulus (HP:0002580)2.05269957
77Osteomyelitis (HP:0002754)2.04288754
78Neoplasm of the tracheobronchial system (HP:0100552)2.03229812
79Gastrointestinal carcinoma (HP:0002672)2.03177133
80Malignant gastrointestinal tract tumors (HP:0006749)2.03177133
81IgM deficiency (HP:0002850)2.03098874
82Increased density of long bones (HP:0006392)2.01714197
83Long eyelashes (HP:0000527)2.01180324
84Frequent falls (HP:0002359)2.00991387
85Renovascular hypertension (HP:0100817)2.00319719
86Recurrent sinusitis (HP:0011108)2.00200732
87Hypopigmentation of the fundus (HP:0007894)1.99061272
88Dilatation of the ascending aorta (HP:0005111)1.96999686
89Abnormality of the 4th metacarpal (HP:0010012)1.96561204
90Granulocytopenia (HP:0001913)1.95714098
91Increased IgE level (HP:0003212)1.94935789
92Agammaglobulinemia (HP:0004432)1.94681701
93Spastic diplegia (HP:0001264)1.92128247
94Enlarged penis (HP:0000040)1.91810234
95Esophageal varix (HP:0002040)1.91786361
96Neonatal hypoglycemia (HP:0001998)1.90610429
97Bronchitis (HP:0012387)1.90392469
98Bowel diverticulosis (HP:0005222)1.90250203
99Chronic obstructive pulmonary disease (HP:0006510)1.89083822
100Obstructive lung disease (HP:0006536)1.89083822
101Elfin facies (HP:0004428)1.88843599
102Colitis (HP:0002583)1.88764277
103Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88750321
104Generalized hypopigmentation of hair (HP:0011358)1.88527115
105Fair hair (HP:0002286)1.87882054
106Autoimmune thrombocytopenia (HP:0001973)1.87458776
107Abnormality of T cell physiology (HP:0011840)1.87333083
108Deviation of the thumb (HP:0009603)1.85707149
109Periodontitis (HP:0000704)1.85442005
110Abnormality of the lower motor neuron (HP:0002366)1.85259456
111Slow saccadic eye movements (HP:0000514)1.84800131
112Widely spaced teeth (HP:0000687)1.84524865
113Urticaria (HP:0001025)1.84358094
114Abnormality of eosinophils (HP:0001879)1.84175734
115Persistence of primary teeth (HP:0006335)1.84169340
116Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83154952
117Eosinophilia (HP:0001880)1.83033078
118Thyroiditis (HP:0100646)1.82256281
119Protrusio acetabuli (HP:0003179)1.81231827
120Prominent nose (HP:0000448)1.80167828
121Glioma (HP:0009733)1.79694642
122Genetic anticipation (HP:0003743)1.79568410
123Dysmetric saccades (HP:0000641)1.79271279
124Bronchiectasis (HP:0002110)1.78704396
125Abnormality of the endocardium (HP:0004306)1.77466937
126Abnormal glucose tolerance (HP:0001952)1.76328699
127Lymphopenia (HP:0001888)1.74669173
128Hypoplasia of the thymus (HP:0000778)1.74627582
129Aortic dissection (HP:0002647)1.74437379
130Lymphangioma (HP:0100764)1.73045562
131Sandal gap (HP:0001852)1.72316402
132Cheilitis (HP:0100825)1.72077848
133Abnormality of the vasculature of the conjunctiva (HP:0008054)1.70991249
134Acute hepatic failure (HP:0006554)1.70587976
135Broad thumb (HP:0011304)1.70541068
136High pitched voice (HP:0001620)1.69854917
137Turricephaly (HP:0000262)1.69602619
138Proximal placement of thumb (HP:0009623)1.69555509
139Upper motor neuron abnormality (HP:0002127)1.69532419
140Biliary tract neoplasm (HP:0100574)1.69312892
141Fatigue (HP:0012378)1.69084601
142Coarse hair (HP:0002208)1.68783818
143Skull defect (HP:0001362)1.68179838
144Gangrene (HP:0100758)1.67907506
145Cervical subluxation (HP:0003308)1.67884798
146Bladder diverticulum (HP:0000015)1.67800968
147IgA deficiency (HP:0002720)1.67557964
148Transitional cell carcinoma of the bladder (HP:0006740)1.66400907
149Leiomyosarcoma (HP:0100243)1.65663900
150Uterine leiomyosarcoma (HP:0002891)1.65663900
151Large earlobe (HP:0009748)1.64930860
152Trigonocephaly (HP:0000243)1.64877762
153Abnormality of the peritoneum (HP:0002585)1.64196022
154Smooth philtrum (HP:0000319)1.62755320
155Recurrent viral infections (HP:0004429)1.62639671
156Increased cerebral lipofuscin (HP:0011813)1.62603036
157Increased nuchal translucency (HP:0010880)1.62474944
158Thin bony cortex (HP:0002753)1.61917152
159Disproportionate tall stature (HP:0001519)1.60616957
160Long toe (HP:0010511)1.60593124
161Neoplasm of the oral cavity (HP:0100649)1.58631753
162Increased CSF protein (HP:0002922)1.58301669
163Increased mean platelet volume (HP:0011877)1.57866472
164Tibial bowing (HP:0002982)1.56692039
165Bicuspid aortic valve (HP:0001647)1.56528428
166Deep venous thrombosis (HP:0002625)1.55289616
167Low anterior hairline (HP:0000294)1.55282988
168Deep philtrum (HP:0002002)1.54523192
169Cutaneous melanoma (HP:0012056)1.54454529
170Viral hepatitis (HP:0006562)1.52988590
171Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.52064566
172Fibrous tissue neoplasm (HP:0012316)1.51974852
173Truncal obesity (HP:0001956)1.51803429
174Radial bowing (HP:0002986)1.51517742
175Bladder carcinoma (HP:0002862)1.51218769
176Bladder neoplasm (HP:0009725)1.51218769
177Cutis marmorata (HP:0000965)1.50797416
178Striae distensae (HP:0001065)1.49341920
179Fibroma (HP:0010614)1.48876402
180Back pain (HP:0003418)1.48523418
181Genu recurvatum (HP:0002816)1.47189685
182Hypoalphalipoproteinemia (HP:0003233)1.46812163
183Peritonitis (HP:0002586)1.45014539
184Obsessive-compulsive behavior (HP:0000722)1.44730438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.20500591
2EEF2K3.58363412
3RIPK43.26141358
4CAMK1D3.13025379
5BLK2.98817735
6TRIB32.72631400
7PKN22.68156798
8CAMK1G2.52772912
9MAP3K102.39728339
10LATS12.39087476
11TTN2.30225693
12SIK12.23810813
13PTK62.08648947
14SCYL21.84156645
15BTK1.82138169
16TXK1.80247510
17PDGFRA1.79089990
18RIPK11.71800392
19TEC1.70391043
20ERN11.68766996
21IKBKE1.66065510
22ICK1.64798674
23PIK3CG1.63812192
24MTOR1.61835641
25BRD41.60131903
26NLK1.59789745
27AKT31.56430665
28GRK61.55356367
29JAK11.54983292
30FES1.53373754
31ACVR1B1.48145353
32FGFR41.45683452
33SYK1.45176226
34STK101.44655428
35TYK21.43285933
36MAP2K31.36095769
37BMX1.35975531
38CDK61.35473886
39BMPR21.34587395
40YES11.30822254
41TNK21.30420827
42WNK11.30190624
43IRAK41.29403998
44NEK21.29384163
45FGFR31.24794521
46FRK1.23541700
47TAOK31.21348857
48STK31.20820654
49IRAK11.20079333
50FLT31.15591649
51PRPF4B1.14485679
52JAK31.14444810
53PDGFRB1.13434346
54FGR1.12247962
55MAP4K11.09547896
56CSF1R1.08459841
57NEK91.06230367
58TGFBR21.04257764
59RPS6KB21.03711996
60CDC71.02267109
61MARK21.00836278
62LCK0.99651332
63LYN0.98372496
64CAMKK20.98061286
65MAP3K60.97489587
66TRPM70.97413182
67CHUK0.96449066
68SGK30.96028247
69EPHB10.94931371
70ALK0.93245627
71LRRK20.91942335
72PAK20.91903010
73PDK10.89210776
74STK40.88115731
75PTK20.86810169
76KSR20.84211965
77CDK40.83818676
78FGFR20.83539892
79JAK20.76663316
80RET0.74745707
81PAK40.74037739
82MAPK70.73600935
83CDK90.73449869
84PTK2B0.73354020
85EPHA20.73311022
86PRKAA20.71936147
87ITK0.70974033
88SGK2230.69920531
89SGK4940.69920531
90MELK0.69910887
91DDR20.68547854
92MET0.67440604
93SIK20.67435568
94INSRR0.66691669
95MAP3K70.66108710
96MAP3K140.65721552
97HCK0.65670457
98PRKCH0.65102141
99MAP3K20.64752173
100EPHA30.63469515
101KSR10.63402173
102MAPKAPK30.62884814
103FER0.62811660
104MAP3K10.61914861
105FGFR10.61212273
106ATR0.60465051
107PDPK10.60070281
108DMPK0.59899109
109EGFR0.59721759
110MAP3K80.58221610
111CSK0.57613982
112PIM10.57282203
113NEK60.56915015
114HIPK20.56609521
115MARK30.56406861
116ATM0.54411836
117CHEK10.54215005
118DYRK1B0.54061601
119PRKAA10.53774633
120PRKCQ0.53126970
121TTK0.52940838
122SGK10.52897434
123STK380.51684647
124MST1R0.49795183
125RPS6KA20.49423123
126PASK0.48263854
127KIT0.48093850
128TBK10.46339943
129STK110.45974415
130MAPK120.45861438
131IKBKB0.45363599
132SGK20.44335397
133CDC42BPA0.44321884
134MAPK110.43906939
135PRKDC0.43302576
136MAP3K130.43144535
137NUAK10.42494562
138MAP3K30.41933845
139TYRO30.41370334
140MATK0.41107371
141MAPK10.40604215
142INSR0.40356744
143ERBB20.39087312
144ZAP700.38671733
145CSNK1D0.37552281
146CDK20.36976985

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.53680586
2Lysine degradation_Homo sapiens_hsa003102.28896111
3Chronic myeloid leukemia_Homo sapiens_hsa052201.71278786
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64941962
5Graft-versus-host disease_Homo sapiens_hsa053321.57650298
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56463224
7Allograft rejection_Homo sapiens_hsa053301.55857426
8Adherens junction_Homo sapiens_hsa045201.55352899
9Small cell lung cancer_Homo sapiens_hsa052221.53202300
10mTOR signaling pathway_Homo sapiens_hsa041501.50624390
11Autoimmune thyroid disease_Homo sapiens_hsa053201.49172239
12MicroRNAs in cancer_Homo sapiens_hsa052061.48180209
13Insulin resistance_Homo sapiens_hsa049311.43290996
14Tuberculosis_Homo sapiens_hsa051521.42529934
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37494749
16Primary immunodeficiency_Homo sapiens_hsa053401.35806617
17One carbon pool by folate_Homo sapiens_hsa006701.34891822
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32478469
19B cell receptor signaling pathway_Homo sapiens_hsa046621.31596781
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29590453
21Type II diabetes mellitus_Homo sapiens_hsa049301.28517539
22Proteoglycans in cancer_Homo sapiens_hsa052051.27284836
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.20910565
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.19700837
25Focal adhesion_Homo sapiens_hsa045101.19491615
26Caffeine metabolism_Homo sapiens_hsa002321.17092032
27Toxoplasmosis_Homo sapiens_hsa051451.16316727
28Hematopoietic cell lineage_Homo sapiens_hsa046401.16027893
29Staphylococcus aureus infection_Homo sapiens_hsa051501.15778507
30Osteoclast differentiation_Homo sapiens_hsa043801.15430825
31Type I diabetes mellitus_Homo sapiens_hsa049401.14319311
32Pancreatic cancer_Homo sapiens_hsa052121.12787525
33Viral carcinogenesis_Homo sapiens_hsa052031.10181625
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08411914
35Choline metabolism in cancer_Homo sapiens_hsa052311.07242545
36Endometrial cancer_Homo sapiens_hsa052131.06996945
37Antigen processing and presentation_Homo sapiens_hsa046121.05289962
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04829265
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.04047533
40Notch signaling pathway_Homo sapiens_hsa043301.03652388
41Selenocompound metabolism_Homo sapiens_hsa004501.01860554
42Arginine biosynthesis_Homo sapiens_hsa002201.00386827
43Acute myeloid leukemia_Homo sapiens_hsa052211.00304709
44AMPK signaling pathway_Homo sapiens_hsa041520.99750741
45Viral myocarditis_Homo sapiens_hsa054160.99207354
46Non-small cell lung cancer_Homo sapiens_hsa052230.99081948
47Prostate cancer_Homo sapiens_hsa052150.98489064
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.97661190
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.97652402
50Dorso-ventral axis formation_Homo sapiens_hsa043200.97445022
51Asthma_Homo sapiens_hsa053100.96910700
52Other glycan degradation_Homo sapiens_hsa005110.96818348
53Leishmaniasis_Homo sapiens_hsa051400.96390456
54Apoptosis_Homo sapiens_hsa042100.95280571
55ABC transporters_Homo sapiens_hsa020100.94159281
56Fatty acid biosynthesis_Homo sapiens_hsa000610.94005671
57Colorectal cancer_Homo sapiens_hsa052100.93429701
58VEGF signaling pathway_Homo sapiens_hsa043700.91260691
59Malaria_Homo sapiens_hsa051440.90990647
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90861716
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90314975
62PPAR signaling pathway_Homo sapiens_hsa033200.89950256
63Systemic lupus erythematosus_Homo sapiens_hsa053220.89259515
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87084695
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.86847594
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86030845
67Measles_Homo sapiens_hsa051620.84806562
68Amoebiasis_Homo sapiens_hsa051460.83448772
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83407987
70HTLV-I infection_Homo sapiens_hsa051660.82514820
71Legionellosis_Homo sapiens_hsa051340.82316607
72TNF signaling pathway_Homo sapiens_hsa046680.81969413
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.81871636
74Complement and coagulation cascades_Homo sapiens_hsa046100.81749270
75Insulin signaling pathway_Homo sapiens_hsa049100.81708149
76ECM-receptor interaction_Homo sapiens_hsa045120.81646224
77Glioma_Homo sapiens_hsa052140.81158944
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80016789
79Prolactin signaling pathway_Homo sapiens_hsa049170.79098373
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78159646
81GnRH signaling pathway_Homo sapiens_hsa049120.78055449
82FoxO signaling pathway_Homo sapiens_hsa040680.77526349
83Bile secretion_Homo sapiens_hsa049760.77255361
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.76959015
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76719797
86ErbB signaling pathway_Homo sapiens_hsa040120.76667905
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.76345897
88Hepatitis B_Homo sapiens_hsa051610.75814209
89Fatty acid degradation_Homo sapiens_hsa000710.75262877
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75216401
91T cell receptor signaling pathway_Homo sapiens_hsa046600.74941119
92HIF-1 signaling pathway_Homo sapiens_hsa040660.74420122
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74135941
94Influenza A_Homo sapiens_hsa051640.73151555
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73016806
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71957941
97Renin-angiotensin system_Homo sapiens_hsa046140.71502803
98Renal cell carcinoma_Homo sapiens_hsa052110.70207342
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68141445
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68053642
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66873444
102Hepatitis C_Homo sapiens_hsa051600.66547681
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.64855178
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64537690
105Platelet activation_Homo sapiens_hsa046110.64188941
106Lysosome_Homo sapiens_hsa041420.63746228
107Herpes simplex infection_Homo sapiens_hsa051680.63511555
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.63073100
109Inositol phosphate metabolism_Homo sapiens_hsa005620.62918599
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62338330
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61848394
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61556225
113Pathways in cancer_Homo sapiens_hsa052000.61203032
114TGF-beta signaling pathway_Homo sapiens_hsa043500.60607241
115Fatty acid metabolism_Homo sapiens_hsa012120.59809917
116Tryptophan metabolism_Homo sapiens_hsa003800.58895719
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58474378
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58190469
119Chemokine signaling pathway_Homo sapiens_hsa040620.58154925
120Hippo signaling pathway_Homo sapiens_hsa043900.57940607
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.57740476
122African trypanosomiasis_Homo sapiens_hsa051430.57339607
123Circadian rhythm_Homo sapiens_hsa047100.55058312
124Fat digestion and absorption_Homo sapiens_hsa049750.54985386
125Glucagon signaling pathway_Homo sapiens_hsa049220.54628709
126Estrogen signaling pathway_Homo sapiens_hsa049150.53109365
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52466873
128Pertussis_Homo sapiens_hsa051330.51024911
129Ether lipid metabolism_Homo sapiens_hsa005650.49291306
130Linoleic acid metabolism_Homo sapiens_hsa005910.48825058
131Thyroid cancer_Homo sapiens_hsa052160.47545915
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.45041193
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44450843
134Phagosome_Homo sapiens_hsa041450.44154547
135Pancreatic secretion_Homo sapiens_hsa049720.42362462
136MAPK signaling pathway_Homo sapiens_hsa040100.42308780

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