SPERT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.95359830
2plasma membrane fusion (GO:0045026)9.93023651
3epithelial cilium movement (GO:0003351)9.70108293
4axonemal dynein complex assembly (GO:0070286)9.66336686
5motile cilium assembly (GO:0044458)9.37456847
6reproduction (GO:0000003)9.32604046
7regulation of cilium movement (GO:0003352)9.05678998
8response to pheromone (GO:0019236)8.91088534
9cilium or flagellum-dependent cell motility (GO:0001539)8.69703126
10cilium movement (GO:0003341)7.85237205
11negative regulation of inclusion body assembly (GO:0090084)7.55525273
12single fertilization (GO:0007338)7.42857136
13sperm capacitation (GO:0048240)7.31121955
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.22346517
15rRNA methylation (GO:0031167)7.21124646
16synaptonemal complex organization (GO:0070193)7.01238625
17spermatogenesis (GO:0007283)6.92456405
18male gamete generation (GO:0048232)6.89948016
19male meiosis (GO:0007140)6.89774316
20piRNA metabolic process (GO:0034587)6.89173072
21synaptonemal complex assembly (GO:0007130)6.83312990
22organic cation transport (GO:0015695)6.82355114
23microtubule depolymerization (GO:0007019)6.73073485
24gamete generation (GO:0007276)6.35594773
25fertilization (GO:0009566)6.33854380
26regulation of inclusion body assembly (GO:0090083)6.24257574
27rRNA modification (GO:0000154)6.21592021
28phosphatidylethanolamine biosynthetic process (GO:0006646)5.84519198
29calcium ion-dependent exocytosis (GO:0017156)5.69069047
30chromosome condensation (GO:0030261)5.67724853
31germ cell development (GO:0007281)5.53225587
32cellular ketone body metabolic process (GO:0046950)5.51799463
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.43181571
34phosphatidylethanolamine metabolic process (GO:0046337)5.38132396
35DNA packaging (GO:0006323)5.36678209
36regulation of microtubule-based movement (GO:0060632)5.35146750
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.34192421
38protein targeting to Golgi (GO:0000042)5.21366263
39glycerol ether metabolic process (GO:0006662)5.13683243
40ventricular system development (GO:0021591)5.12347963
41cell recognition (GO:0008037)5.01317855
42multicellular organismal reproductive process (GO:0048609)5.01068812
43spermatid nucleus differentiation (GO:0007289)4.99344220
44establishment of protein localization to Golgi (GO:0072600)4.94191874
45male meiosis I (GO:0007141)4.88330064
46microtubule severing (GO:0051013)4.86437308
47ketone body metabolic process (GO:1902224)4.83481203
48retrograde transport, vesicle recycling within Golgi (GO:0000301)4.79471960
49ether metabolic process (GO:0018904)4.74666427
50regulation of Rab GTPase activity (GO:0032313)4.73742621
51positive regulation of Rab GTPase activity (GO:0032851)4.73742621
52membrane protein intracellular domain proteolysis (GO:0031293)4.71665488
53tooth mineralization (GO:0034505)4.71442566
54seminiferous tubule development (GO:0072520)4.64338924
55chromosome organization involved in meiosis (GO:0070192)4.61093202
56muscle organ morphogenesis (GO:0048644)4.49847269
57cranial nerve morphogenesis (GO:0021602)4.49483372
58regulation of transcription involved in cell fate commitment (GO:0060850)4.44133669
59DNA methylation involved in gamete generation (GO:0043046)4.42354335
60left/right pattern formation (GO:0060972)4.41456885
61outer ear morphogenesis (GO:0042473)4.39140989
62muscle cell fate commitment (GO:0042693)4.39124501
63coenzyme catabolic process (GO:0009109)4.34149526
64centriole replication (GO:0007099)4.32406899
65sexual reproduction (GO:0019953)4.30297163
66protein-DNA complex disassembly (GO:0032986)4.24283818
67nucleosome disassembly (GO:0006337)4.24283818
68meiotic nuclear division (GO:0007126)4.15780209
69single strand break repair (GO:0000012)4.13780279
70chaperone-mediated protein complex assembly (GO:0051131)4.13724307
71response to acidic pH (GO:0010447)4.05805295
72outflow tract septum morphogenesis (GO:0003148)4.04980936
73regulation of cardioblast proliferation (GO:0003264)4.03373819
74regulation of secondary heart field cardioblast proliferation (GO:0003266)4.03373819
75multicellular organismal development (GO:0007275)4.01796413
76coronary vasculature morphogenesis (GO:0060977)3.99156201
77centriole assembly (GO:0098534)3.91295409
78meiosis I (GO:0007127)3.90996611
79negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.71851797
80cellular response to pH (GO:0071467)3.68402540
81protein polyglutamylation (GO:0018095)3.68395243
82protein localization to Golgi apparatus (GO:0034067)3.65613617
83positive regulation of skeletal muscle tissue development (GO:0048643)3.60330628
84mitotic G1 DNA damage checkpoint (GO:0031571)3.57926364
85regulation of centriole replication (GO:0046599)3.54605304
86genitalia morphogenesis (GO:0035112)3.52947030
87regulation of spindle checkpoint (GO:0090231)3.48140329
88microtubule polymerization or depolymerization (GO:0031109)3.47116825
89embryonic viscerocranium morphogenesis (GO:0048703)3.46526009
90cerebral cortex neuron differentiation (GO:0021895)3.45726519
91sequestering of actin monomers (GO:0042989)3.45518030
92protein refolding (GO:0042026)3.44184857
93meiotic cell cycle (GO:0051321)3.38512664
94mesenchymal cell differentiation involved in renal system development (GO:2001012)3.28681853
95mesenchymal cell differentiation involved in kidney development (GO:0072161)3.28681853
96glycolytic process (GO:0006096)3.26656224
97regulation of interleukin-13 production (GO:0032656)3.22024676
98nucleus organization (GO:0006997)3.21907234
99lymph vessel development (GO:0001945)3.21621608
100protein K11-linked deubiquitination (GO:0035871)3.20387782
101mitotic sister chromatid cohesion (GO:0007064)3.19927178
102monoubiquitinated protein deubiquitination (GO:0035520)3.19265384
103negative regulation of gene expression, epigenetic (GO:0045814)3.19222276
104mitotic G1/S transition checkpoint (GO:0044819)3.18055583
105carnitine transport (GO:0015879)3.15891491
106amino-acid betaine transport (GO:0015838)3.15891491
107histone exchange (GO:0043486)3.15255793
108RNA destabilization (GO:0050779)3.12520507
109cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12229896
110RNA localization (GO:0006403)3.11955012
111G1 DNA damage checkpoint (GO:0044783)3.11779445
112positive regulation of myotube differentiation (GO:0010831)3.11741659
113DNA conformation change (GO:0071103)3.06864857
114histone H3-K9 demethylation (GO:0033169)3.06759979
115protein localization to cilium (GO:0061512)3.05959742
116negative regulation of Rho protein signal transduction (GO:0035024)3.03632896
117interferon-gamma secretion (GO:0072643)3.03249674
118membrane protein ectodomain proteolysis (GO:0006509)3.01263828
119polyamine biosynthetic process (GO:0006596)2.98488632
120carnitine transmembrane transport (GO:1902603)2.95942481
121polyol catabolic process (GO:0046174)2.95545100
122nucleoside diphosphate phosphorylation (GO:0006165)2.95205741
123positive regulation of macrophage activation (GO:0043032)2.88726985
124alditol metabolic process (GO:0019400)2.83261353
125meiotic cell cycle process (GO:1903046)2.78999778
126regulation of cilium assembly (GO:1902017)2.78931834
127cilium organization (GO:0044782)2.74882699
128chromatin silencing (GO:0006342)2.71559928
129microtubule-based movement (GO:0007018)2.69325008
130mitochondrion degradation (GO:0000422)2.68627344
131synapsis (GO:0007129)2.65367388
132cilium assembly (GO:0042384)2.63898267
133GTP biosynthetic process (GO:0006183)2.62518633
134cilium morphogenesis (GO:0060271)2.60164789
135cellular component assembly involved in morphogenesis (GO:0010927)2.59709923
136peptidyl-glutamic acid modification (GO:0018200)2.55181955
137lactate metabolic process (GO:0006089)2.54596912
138negative regulation of organelle assembly (GO:1902116)2.54077120
139axoneme assembly (GO:0035082)2.51786270
140intraciliary transport (GO:0042073)2.51034578
141positive regulation of glycolytic process (GO:0045821)2.48845147
142gene silencing by RNA (GO:0031047)2.46035260
143sperm motility (GO:0030317)14.3978466
144fusion of sperm to egg plasma membrane (GO:0007342)13.0394027
145acrosome reaction (GO:0007340)12.5777969
146cell wall macromolecule catabolic process (GO:0016998)12.4473410
147cell wall macromolecule metabolic process (GO:0044036)12.4473410
148sperm-egg recognition (GO:0035036)11.5869738
149acrosome assembly (GO:0001675)11.1768786
150multicellular organism reproduction (GO:0032504)10.7612029
151binding of sperm to zona pellucida (GO:0007339)10.5629130
152cell-cell recognition (GO:0009988)10.3654380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.05615487
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.92716741
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.83135543
4EZH2_22144423_ChIP-Seq_EOC_Human4.28475694
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.97167706
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.88280307
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08239988
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.92380432
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76310949
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.72832426
11VDR_22108803_ChIP-Seq_LS180_Human2.62901437
12BCL6_27268052_Chip-Seq_Bcells_Human2.48328956
13ERA_21632823_ChIP-Seq_H3396_Human2.41513939
14LXR_22292898_ChIP-Seq_THP-1_Human2.39174037
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.30697522
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.28591961
17RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.23625460
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.19258955
19CTCF_27219007_Chip-Seq_Bcells_Human2.15173178
20RAC3_21632823_ChIP-Seq_H3396_Human2.13749754
21* P68_20966046_ChIP-Seq_HELA_Human2.12389020
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.06314486
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05724948
24* BCOR_27268052_Chip-Seq_Bcells_Human2.05651326
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.05097505
26SMC4_20622854_ChIP-Seq_HELA_Human2.04082469
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02842520
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.02565680
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02225436
30* E2F1_20622854_ChIP-Seq_HELA_Human1.99732507
31ZNF274_21170338_ChIP-Seq_K562_Hela1.96215140
32PHF8_20622854_ChIP-Seq_HELA_Human1.95898566
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93436338
34TP63_22573176_ChIP-Seq_HFKS_Human1.86381812
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.80501528
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79552655
37TAF2_19829295_ChIP-Seq_ESCs_Human1.76591826
38* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75925936
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.75676871
40STAT1_17558387_ChIP-Seq_HELA_Human1.74677936
41P300_27268052_Chip-Seq_Bcells_Human1.72641549
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.70669580
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68887756
44SOX2_22085726_ChIP-Seq_NPCs_Mouse1.68209468
45OCT4_20526341_ChIP-Seq_ESCs_Human1.63716293
46* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63043001
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.57488982
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.57391361
49GATA3_21867929_ChIP-Seq_CD8_Mouse1.56877708
50MYC_19829295_ChIP-Seq_ESCs_Human1.55950933
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.52548277
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52427748
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50901640
54SA1_27219007_Chip-Seq_Bcells_Human1.50189438
55FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49686404
56P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.47178912
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.46361291
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.45897286
59KDM2B_26808549_Chip-Seq_REH_Human1.42936645
60* CTCF_21964334_Chip-Seq_Bcells_Human1.42543516
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42168436
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41995369
63CBP_20019798_ChIP-Seq_JUKART_Human1.41995369
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41840324
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41404165
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.39246183
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38220039
68P53_21459846_ChIP-Seq_SAOS-2_Human1.37454752
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.37181984
70LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35373023
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32875021
72REST_21632747_ChIP-Seq_MESCs_Mouse1.30846943
73FOXP1_21924763_ChIP-Seq_HESCs_Human1.29683391
74SPI1_20517297_ChIP-Seq_HL60_Human1.29620688
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29513780
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.29083210
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27513757
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25468428
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25292823
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25063330
81GF1_26923725_Chip-Seq_HPCs_Mouse1.24570295
82RAD21_21589869_ChIP-Seq_MESCs_Mouse1.23104707
83CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22977043
84* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22543034
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.21403058
86CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21163768
87SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21042337
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.20694935
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20457932
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.20053515
91* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19865724
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.18530587
93SPI1_26923725_Chip-Seq_HPCs_Mouse1.17383638
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16441369
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16441369
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.16422980
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16280502
98SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15686352
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15504614
100RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13497380
101DROSHA_22980978_ChIP-Seq_HELA_Human1.13338072
102ERG_20517297_ChIP-Seq_VCAP_Human1.13294249
103CSB_26484114_Chip-Seq_FIBROBLAST_Human1.12682734
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12456807
105RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12219346
106MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12193412
107MYC_27129775_Chip-Seq_CORNEA_Mouse1.11900802
108STAT1_20625510_ChIP-Seq_HELA_Human1.09060996
109E2F1_17053090_ChIP-ChIP_MCF-7_Human1.08761883
110CEBPB_22108803_ChIP-Seq_LS180_Human1.07557726
111GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06977527
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.06956844
113JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06510602
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06084133
115TAF15_26573619_Chip-Seq_HEK293_Human1.05984459
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05910652
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05135868
118CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04792781
119ESET_19884257_ChIP-Seq_ESCs_Mouse1.04632907
120HNFA_21074721_ChIP-Seq_CACO-2_Human1.04453655
121CTCF_20526341_ChIP-Seq_ESCs_Human1.04097933
122* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03779949
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02986156
124RARA_24833708_ChIP-Seq_LIVER_Mouse1.02768321
125SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02527927
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02435339
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02141271
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01705438
129RBPJ_21746931_ChIP-Seq_IB4_Human1.01561670
130YY1_22570637_ChIP-Seq_MALME-3M_Human1.01386028
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00127929
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.99954490
133* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99307940
134SOX11_22085726_ChIP-Seq_ESNs_Mouse0.98586989
135FOXH1_21741376_ChIP-Seq_ESCs_Human0.98549480
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.98147469
137OCT4_19829295_ChIP-Seq_ESCs_Human0.97989102
138CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97235520
139* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97213908
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97000798
141KLF4_19829295_ChIP-Seq_ESCs_Human0.96898776
142* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96833153
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96564009
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.95259571
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94930222
146CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94832895
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93657873
148CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93430323
149NFYB_21822215_ChIP-Seq_K562_Human0.93303833
150NANOG_20526341_ChIP-Seq_ESCs_Human0.91918995
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91638850
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.91452936
153OCT4_18555785_Chip-Seq_ESCs_Mouse0.89550062
154HOXB7_26014856_ChIP-Seq_BT474_Human0.88940506
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.88855643
156BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88759861
157SOX2_21211035_ChIP-Seq_LN229_Human0.87794517
158TBL1_22424771_ChIP-Seq_293T_Human0.87587854
159P53_22387025_ChIP-Seq_ESCs_Mouse0.86829618
160KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86760640
161SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86435255
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86300886
163SMAD4_21741376_ChIP-Seq_EPCs_Human0.85703728
164NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84542552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04907879
2MP0001929_abnormal_gametogenesis5.52560344
3MP0000678_abnormal_parathyroid_gland4.32107631
4MP0008877_abnormal_DNA_methylation3.90600918
5MP0001348_abnormal_lacrimal_gland3.70595693
6MP0002161_abnormal_fertility/fecundity3.34235467
7MP0002210_abnormal_sex_determination3.31053732
8MP0005670_abnormal_white_adipose3.13445760
9MP0002249_abnormal_larynx_morphology3.04564737
10MP0001145_abnormal_male_reproductive2.80229117
11MP0003718_maternal_effect2.68521495
12MP0002132_abnormal_respiratory_system2.57979356
13MP0000653_abnormal_sex_gland2.44703664
14MP0002653_abnormal_ependyma_morphology2.33498343
15MP0002822_catalepsy2.21394340
16MP0005379_endocrine/exocrine_gland_phen2.08192144
17MP0000049_abnormal_middle_ear2.01062949
18MP0005410_abnormal_fertilization16.6464616
19MP0003646_muscle_fatigue1.73869749
20MP0002127_abnormal_cardiovascular_syste1.52100326
21MP0004510_myositis1.48742643
22MP0000681_abnormal_thyroid_gland1.47382668
23MP0004233_abnormal_muscle_weight1.46735928
24MP0002160_abnormal_reproductive_system1.43770100
25MP0009053_abnormal_anal_canal1.41353611
26MP0002735_abnormal_chemical_nociception1.39497887
27MP0002138_abnormal_hepatobiliary_system1.36764299
28MP0005623_abnormal_meninges_morphology1.34611852
29MP0005423_abnormal_somatic_nervous1.21660045
30MP0010030_abnormal_orbit_morphology1.20430290
31MP0002282_abnormal_trachea_morphology1.19962133
32MP0008004_abnormal_stomach_pH1.16984202
33MP0001765_abnormal_ion_homeostasis1.14744503
34MP0005395_other_phenotype1.12120255
35MP0003693_abnormal_embryo_hatching1.03281794
36MP0005310_abnormal_salivary_gland1.02613952
37MP0001984_abnormal_olfaction0.99069670
38MP0001963_abnormal_hearing_physiology0.98482410
39MP0001879_abnormal_lymphatic_vessel0.97445960
40MP0001485_abnormal_pinna_reflex0.94788921
41MP0000026_abnormal_inner_ear0.94682276
42MP0005451_abnormal_body_composition0.94084609
43MP0004859_abnormal_synaptic_plasticity0.88815929
44MP0003077_abnormal_cell_cycle0.87858124
45MP0005499_abnormal_olfactory_system0.87786039
46MP0005394_taste/olfaction_phenotype0.87786039
47MP0001486_abnormal_startle_reflex0.86894178
48MP0004957_abnormal_blastocyst_morpholog0.86877341
49MP0002234_abnormal_pharynx_morphology0.86632217
50MP0005647_abnormal_sex_gland0.85599926
51MP0001905_abnormal_dopamine_level0.85381387
52MP0001873_stomach_inflammation0.81511111
53MP0008995_early_reproductive_senescence0.80065999
54MP0003115_abnormal_respiratory_system0.78683762
55MP0002733_abnormal_thermal_nociception0.74726243
56MP0008058_abnormal_DNA_repair0.72795878
57MP0005389_reproductive_system_phenotype0.72291967
58MP0005248_abnormal_Harderian_gland0.72118914
59MP0000955_abnormal_spinal_cord0.71565329
60MP0003878_abnormal_ear_physiology0.69390670
61MP0005377_hearing/vestibular/ear_phenot0.69390670
62MP0009046_muscle_twitch0.69026685
63MP0005666_abnormal_adipose_tissue0.67215143
64MP0002254_reproductive_system_inflammat0.63793466
65MP0005636_abnormal_mineral_homeostasis0.63222791
66MP0000733_abnormal_muscle_development0.62886823
67MP0003011_delayed_dark_adaptation0.60859270
68MP0003329_amyloid_beta_deposits0.60531474
69MP0008932_abnormal_embryonic_tissue0.59741756
70MP0000516_abnormal_urinary_system0.59492421
71MP0005367_renal/urinary_system_phenotyp0.59492421
72MP0000470_abnormal_stomach_morphology0.57923303
73MP0008789_abnormal_olfactory_epithelium0.56107879
74MP0001270_distended_abdomen0.55856081
75MP0003699_abnormal_female_reproductive0.54075967
76MP0005166_decreased_susceptibility_to0.52037266
77MP0008569_lethality_at_weaning0.51881357
78MP0004036_abnormal_muscle_relaxation0.51805947
79MP0000569_abnormal_digit_pigmentation0.50208729
80MP0001764_abnormal_homeostasis0.49772141
81MP0001324_abnormal_eye_pigmentation0.48386579
82MP0002269_muscular_atrophy0.48133999
83MP0005083_abnormal_biliary_tract0.47867246
84MP0009697_abnormal_copulation0.47665359
85MP0006292_abnormal_olfactory_placode0.47352802
86MP0005645_abnormal_hypothalamus_physiol0.47330347
87MP0000358_abnormal_cell_content/0.47084459
88MP0002736_abnormal_nociception_after0.46466697
89MP0010094_abnormal_chromosome_stability0.46302982
90MP0000534_abnormal_ureter_morphology0.45408468
91MP0000566_synostosis0.45054495
92MP0001545_abnormal_hematopoietic_system0.44995491
93MP0005397_hematopoietic_system_phenotyp0.44995491
94MP0000762_abnormal_tongue_morphology0.44010254
95MP0001293_anophthalmia0.43799344
96MP0009278_abnormal_bone_marrow0.43084452
97MP0002796_impaired_skin_barrier0.42870196
98MP0000003_abnormal_adipose_tissue0.42442785
99MP0002557_abnormal_social/conspecific_i0.42367901
100MP0003119_abnormal_digestive_system0.42180833
101MP0002932_abnormal_joint_morphology0.41222806
102MP0005535_abnormal_body_temperature0.40792459
103MP0002163_abnormal_gland_morphology0.40735175
104MP0002067_abnormal_sensory_capabilities0.39976201
105MP0005332_abnormal_amino_acid0.39627298
106MP0009115_abnormal_fat_cell0.39421335
107MP0001970_abnormal_pain_threshold0.39068187
108MP0002928_abnormal_bile_duct0.38526075
109MP0003137_abnormal_impulse_conducting0.38408263
110MP0003111_abnormal_nucleus_morphology0.37997631
111MP0001666_abnormal_nutrient_absorption0.36823023
112MP0006036_abnormal_mitochondrial_physio0.36517690
113MP0003950_abnormal_plasma_membrane0.36006507
114MP0005253_abnormal_eye_physiology0.35735458
115MP0003942_abnormal_urinary_system0.33939795
116MP0002102_abnormal_ear_morphology0.33580540
117MP0005551_abnormal_eye_electrophysiolog0.32475025
118MP0004085_abnormal_heartbeat0.31920067
119MP0000467_abnormal_esophagus_morphology0.31710058
120MP0001119_abnormal_female_reproductive0.31308259
121MP0002971_abnormal_brown_adipose0.31251043
122MP0003879_abnormal_hair_cell0.31161278
123MP0000604_amyloidosis0.29532842
124MP0001730_embryonic_growth_arrest0.29342822
125MP0005391_vision/eye_phenotype0.28096897
126MP0002295_abnormal_pulmonary_circulatio0.27703981
127MP0004811_abnormal_neuron_physiology0.25977277
128MP0004133_heterotaxia0.25724573
129MP0003861_abnormal_nervous_system0.25165978
130MP0002139_abnormal_hepatobiliary_system0.25111069
131MP0003633_abnormal_nervous_system0.23827117
132MP0001968_abnormal_touch/_nociception0.23395222
133MP0003787_abnormal_imprinting0.23329694
134MP0005375_adipose_tissue_phenotype0.23088599
135MP0002169_no_abnormal_phenotype0.22880085
136MP0002873_normal_phenotype0.22645062
137MP0001849_ear_inflammation0.22527924
138MP0003948_abnormal_gas_homeostasis0.22086559
139MP0008961_abnormal_basal_metabolism0.21619127
140MP0002152_abnormal_brain_morphology0.21446531
141MP0003631_nervous_system_phenotype0.20335345
142MP0004742_abnormal_vestibular_system0.19954515
143MP0004270_analgesia0.19384928
144MP0003786_premature_aging0.18537589
145MP0001727_abnormal_embryo_implantation0.18335136
146MP0000751_myopathy0.18092062
147MP0006035_abnormal_mitochondrial_morpho0.17545178
148MP0004145_abnormal_muscle_electrophysio0.16756188
149MP0002092_abnormal_eye_morphology0.15482648
150MP0002084_abnormal_developmental_patter0.15155886
151MP0004019_abnormal_vitamin_homeostasis0.15013229
152MP0008875_abnormal_xenobiotic_pharmacok0.14384448
153MP0004043_abnormal_pH_regulation0.14310308
154MP0000001_mammalian_phenotype0.14188922
155MP0001661_extended_life_span0.14082995
156MP0008007_abnormal_cellular_replicative0.13914322
157MP0000462_abnormal_digestive_system0.13770480
158MP0000313_abnormal_cell_death0.13100402
159MP0005365_abnormal_bile_salt0.12972058
160MP0002693_abnormal_pancreas_physiology0.12892585
161MP0002229_neurodegeneration0.12410868
162MP0005380_embryogenesis_phenotype0.12340837
163MP0001672_abnormal_embryogenesis/_devel0.12340837
164MP0002118_abnormal_lipid_homeostasis0.11857022
165MP0001697_abnormal_embryo_size0.11658171
166MP0003959_abnormal_lean_body0.11553077

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.20645632
2Abnormal respiratory motile cilium morphology (HP:0005938)9.19698495
3Abnormal respiratory epithelium morphology (HP:0012253)9.19698495
4Severe visual impairment (HP:0001141)7.80797536
5Rhinitis (HP:0012384)7.32666114
6Infertility (HP:0000789)7.22430979
7Chronic bronchitis (HP:0004469)7.21573011
8Abnormal ciliary motility (HP:0012262)7.18279767
9Nasal polyposis (HP:0100582)6.39971615
10Male infertility (HP:0003251)5.42297226
11Abnormality of the nasal mucosa (HP:0000433)5.26234565
12Unilateral renal agenesis (HP:0000122)4.99472608
13Bronchitis (HP:0012387)4.61320841
14Bony spicule pigmentary retinopathy (HP:0007737)4.50436340
15Abnormality of the aortic arch (HP:0012303)4.40125298
16Bronchiectasis (HP:0002110)4.39271698
17Attenuation of retinal blood vessels (HP:0007843)4.24788101
18Nephronophthisis (HP:0000090)4.13558487
19Resting tremor (HP:0002322)4.07690169
20Abnormal spermatogenesis (HP:0008669)3.89532420
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.82977384
22Abnormal rod and cone electroretinograms (HP:0008323)3.73647735
23Hypoplastic left heart (HP:0004383)3.68300438
24Abnormality of the parathyroid morphology (HP:0011766)3.59712736
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.43253802
26Generalized aminoaciduria (HP:0002909)3.42086230
27Periauricular skin pits (HP:0100277)3.41711826
28Preauricular pit (HP:0004467)3.41711826
29Transposition of the great arteries (HP:0001669)3.37114000
30Abnormal connection of the cardiac segments (HP:0011545)3.37114000
31Abnormal ventriculo-arterial connection (HP:0011563)3.37114000
32Recurrent otitis media (HP:0000403)3.30090433
33Chronic hepatic failure (HP:0100626)3.28589999
34Hyperthyroidism (HP:0000836)3.25660443
35Recurrent sinusitis (HP:0011108)3.19353705
36Tetany (HP:0001281)3.18697377
37Potter facies (HP:0002009)3.18504623
38Facial shape deformation (HP:0011334)3.18504623
39Hyperkalemia (HP:0002153)3.18223307
40Abnormality of macular pigmentation (HP:0008002)3.12850826
41Hypoplastic heart (HP:0001961)3.12386342
42Abnormality of the renal medulla (HP:0100957)3.10289158
43Truncus arteriosus (HP:0001660)3.08144343
44Enlarged epiphyses (HP:0010580)2.98046135
45Impulsivity (HP:0100710)2.92022879
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89393198
47Recurrent bronchitis (HP:0002837)2.87819394
48Hypoplastic ischia (HP:0003175)2.83275173
49Tubulointerstitial nephritis (HP:0001970)2.76919105
50Skin pits (HP:0100276)2.73954628
51Renal Fanconi syndrome (HP:0001994)2.70695775
52Cholecystitis (HP:0001082)2.68554285
53Abnormal gallbladder physiology (HP:0012438)2.68554285
54Hypoparathyroidism (HP:0000829)2.63628507
55Tubular atrophy (HP:0000092)2.60299484
56Amblyopia (HP:0000646)2.56027317
57Abnormality of midbrain morphology (HP:0002418)2.52332636
58Molar tooth sign on MRI (HP:0002419)2.52332636
59Sclerocornea (HP:0000647)2.52139408
60Cone-rod dystrophy (HP:0000548)2.51099713
61Hypoplasia of the thymus (HP:0000778)2.48031420
62Tubulointerstitial abnormality (HP:0001969)2.43289623
63Progressive sensorineural hearing impairment (HP:0000408)2.42068800
64Atelectasis (HP:0100750)2.40147266
65Abnormality of the ischium (HP:0003174)2.39924796
66Hyponatremia (HP:0002902)2.35571803
67Azoospermia (HP:0000027)2.34893847
68Gonadotropin excess (HP:0000837)2.34190978
69Flattened epiphyses (HP:0003071)2.27933628
70Dyschromatopsia (HP:0007641)2.27399112
71Recurrent bacterial skin infections (HP:0005406)2.26768307
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.26350099
73Medial flaring of the eyebrow (HP:0010747)2.24226794
74Seborrheic dermatitis (HP:0001051)2.16836245
75Hypophosphatemic rickets (HP:0004912)2.15449762
76Choroideremia (HP:0001139)2.13707556
77Postural instability (HP:0002172)2.13452731
78Bowel incontinence (HP:0002607)2.11785906
79Abnormality of the costochondral junction (HP:0000919)2.09341377
80Spastic tetraparesis (HP:0001285)2.07817426
81Abnormal large intestine physiology (HP:0012700)2.04979655
82Tubulointerstitial fibrosis (HP:0005576)2.01549213
83Dynein arm defect of respiratory motile cilia (HP:0012255)13.4395112
84Absent/shortened dynein arms (HP:0200106)13.4395112
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8726981
86Decreased central vision (HP:0007663)1.99567710
87Abnormality of the pubic bones (HP:0003172)1.95591833
88Glycosuria (HP:0003076)1.94410325
89Abnormality of urine glucose concentration (HP:0011016)1.94410325
90Down-sloping shoulders (HP:0200021)1.93787680
91Aplasia/Hypoplasia of the macula (HP:0008059)1.92804969
92Ventricular tachycardia (HP:0004756)1.90126023
93Abnormality of potassium homeostasis (HP:0011042)1.87420312
94Hypertensive crisis (HP:0100735)1.86817816
95Abnormality of T cell physiology (HP:0011840)1.86324732
96Muscle fiber atrophy (HP:0100295)1.86131840
97Delusions (HP:0000746)1.85968730
98Abnormality of chromosome segregation (HP:0002916)1.85660193
99Heterotopia (HP:0002282)1.84586989
100Hypoalphalipoproteinemia (HP:0003233)1.84319955
101Hemorrhage of the eye (HP:0011885)1.83900624
102Aplasia/Hypoplasia of the thymus (HP:0010515)1.83363658
103Bifid uvula (HP:0000193)1.82513319
104Hypergonadotropic hypogonadism (HP:0000815)1.80260254
105Increased purine levels (HP:0004368)1.79132313
106Hyperuricemia (HP:0002149)1.79132313
107Insulin-resistant diabetes mellitus (HP:0000831)1.78889428
108Abnormal drinking behavior (HP:0030082)1.78151014
109Polydipsia (HP:0001959)1.78151014
110Postaxial foot polydactyly (HP:0001830)1.74615721
111Bile duct proliferation (HP:0001408)1.73221401
112Abnormal biliary tract physiology (HP:0012439)1.73221401
113Stage 5 chronic kidney disease (HP:0003774)1.72622104
114Neurofibrillary tangles (HP:0002185)1.71007388
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66959851
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63550351
117Double outlet right ventricle (HP:0001719)1.63490305
118Congenital malformation of the right heart (HP:0011723)1.63490305
119Congenital hepatic fibrosis (HP:0002612)1.62915024
120Abnormality of renal excretion (HP:0011036)1.61372826
121Bell-shaped thorax (HP:0001591)1.59720040
122Abnormality of the renal cortex (HP:0011035)1.57583778
123Short ribs (HP:0000773)1.56914743
124Asymmetric septal hypertrophy (HP:0001670)1.52301844
125Oculomotor apraxia (HP:0000657)1.49282709
126Aplasia/Hypoplasia of the lens (HP:0008063)1.45120251
127Bundle branch block (HP:0011710)1.44839422
128Renal dysplasia (HP:0000110)1.41736810
129Abnormality of dentin (HP:0010299)1.41196568
130Cerebral inclusion bodies (HP:0100314)1.40849462
131Abnormal urine output (HP:0012590)1.39643204
132Abnormality of permanent molar morphology (HP:0011071)1.37745330
133Abnormality of the dental root (HP:0006486)1.37745330
134Taurodontia (HP:0000679)1.37745330
135Easy fatigability (HP:0003388)1.37387153
136Postaxial hand polydactyly (HP:0001162)1.37118331
137Deformed sella turcica (HP:0002681)1.35162807
138Exercise-induced myalgia (HP:0003738)1.34436416
139Hemiparesis (HP:0001269)1.33007191
140Cystic liver disease (HP:0006706)1.32654637
141Abnormality of the lower motor neuron (HP:0002366)1.31800578
142Hypercholesterolemia (HP:0003124)1.31776237
143Absent epiphyses (HP:0010577)1.30675673
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30675673
145Fibular hypoplasia (HP:0003038)1.30670764
146Facial cleft (HP:0002006)1.28555157
147Abnormality of the dental pulp (HP:0006479)1.28298525
148Fatigable weakness (HP:0003473)1.27457512
149Abnormality of the neuromuscular junction (HP:0003398)1.27457512
150Myoglobinuria (HP:0002913)1.27070871
151Abnormality of molar (HP:0011077)1.26335455
152Abnormality of molar morphology (HP:0011070)1.26335455
153Sensory axonal neuropathy (HP:0003390)1.24564792
154Loss of speech (HP:0002371)1.24174048
155Truncal obesity (HP:0001956)1.23509847
156Constricted visual fields (HP:0001133)1.23392263
157Broad distal phalanx of finger (HP:0009836)1.21389008
158Cerebellar dysplasia (HP:0007033)1.21345206
159Amyotrophic lateral sclerosis (HP:0007354)1.19785521
160Chronic sinusitis (HP:0011109)1.17479656
161Neoplasm of the heart (HP:0100544)1.17010224
162Short femoral neck (HP:0100864)1.16566374
163Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.16094416
164Nephropathy (HP:0000112)1.14300890
165Rhabdomyolysis (HP:0003201)1.14251469
166Short thorax (HP:0010306)1.14182868
167Pancreatic fibrosis (HP:0100732)1.13876934
168Polyuria (HP:0000103)1.12962920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.68790153
2PDK47.68790153
3TESK16.76629229
4PRKD35.82407164
5PDK24.94857665
6ICK4.89761974
7DDR24.46735178
8MAP4K23.38572377
9VRK22.72418226
10INSRR2.71862119
11TAF12.56752213
12SMG12.38812353
13PTK2B2.26212463
14WNK42.11302006
15PLK22.06533118
16STK391.99029059
17STK381.95873619
18PNCK1.94741055
19STK161.86532366
20CDK71.85820631
21BRD41.81393061
22DYRK1B1.72581561
23NEK21.59075981
24MST1R1.51464106
25MAP3K91.49769158
26BUB11.40186153
27NME21.37714025
28VRK11.28106931
29ARAF1.23920089
30PDK11.23124179
31KSR20.98780699
32TYRO30.96398018
33MAP3K80.95579950
34NUAK10.92905868
35DYRK30.90569393
36MAPK150.88413949
37LATS20.87863968
38TLK10.84842464
39PIK3CG0.83295752
40EEF2K0.82027180
41PDPK10.82008923
42CAMK1D0.80165441
43WNK10.79733503
44ZAK0.79304517
45MAPK110.76720238
46RIPK40.73442174
47TTK0.71908978
48IRAK30.70501586
49IRAK10.68811189
50CSNK1G30.65536668
51PASK0.65453063
52STK30.65146657
53TESK20.64844646
54MAP3K110.64166880
55ABL20.63235011
56CHEK20.62354011
57CCNB10.61932114
58CAMK1G0.59963933
59RPS6KA20.57928817
60MAP2K60.55465162
61CSNK1A1L0.54490356
62PINK10.54051345
63MUSK0.53456480
64MAP2K20.52860883
65STK38L0.52151491
66PRKAA20.51064295
67GRK50.50002361
68CDK90.46032834
69PAK10.45336515
70NTRK20.44973481
71NME10.44281549
72RPS6KL10.43368308
73RPS6KC10.43368308
74IKBKB0.42938948
75LMTK20.40643111
76UHMK10.40401788
77CHEK10.39124041
78IRAK20.37372729
79RPS6KA60.37209747
80CSNK1G20.35250654
81PRKCG0.34881984
82CAMK40.34325196
83CSNK1G10.33933593
84CDK30.33179728
85BLK0.32773975
86PAK20.32190811
87MAPKAPK50.31987125
88MARK20.31218085
89CAMK10.30920998
90MAP3K100.30708683
91DYRK20.30546624
92BCKDK0.29319150
93MAP2K70.28502235
94MTOR0.28480608
95PAK40.28022360
96ATM0.27807227
97PLK40.27400038
98MELK0.25738550
99DAPK10.25648028
100RPS6KA50.25500342
101SIK20.24501469
102MAPK10.22249071
103PRKAA10.22137484
104CAMKK10.22029802
105ROCK10.21767318
106ATR0.21315147
107MAP3K20.19733158
108CDC70.19356159
109PRKCZ0.19102959
110NEK60.18766966
111BRAF0.17113641
112MET0.16966327
113CDK150.16122144
114BMPR1B0.15850893
115WEE10.15378490
116BRSK20.14806516
117PRKCQ0.14143916
118CHUK0.13998560
119RPS6KB10.13934672
120MAP3K130.13896958
121PLK10.13871363
122AKT20.13606209
123CDK180.13335928
124CDK11A0.12098253
125STK100.11625210
126BRSK10.11374923
127RPS6KA10.09342880
128PRKG20.07847458
129GSK3B0.07719283
130CDK140.07550191
131CDK60.05627435
132CSNK2A10.05372558
133STK110.04595974
134CSNK1D0.04331351
135CAMK2A0.03786639
136PAK60.03722337
137CDK20.03508674
138CDK10.03131923
139PIM10.02946953
140CDK120.02576553
141CSF1R0.02186487
142TAOK10.01939812
143PRKCD0.01555561
144PRKG10.01507855
145MAPK80.01351507
146MAP3K10.01286404
147CDK40.00746061
148MARK30.00430708
149AURKA0.00286236
150PRKCB0.00222876
151PRKACG0.00167043
152EPHB1-0.0284889
153RPS6KA3-0.0273018
154EGFR-0.0255516
155PDGFRB-0.0237226
156TRIB3-0.0169853
157MAP3K5-0.0132845
158PKN1-0.0104322
159MAP3K4-0.0092194
160CSNK2A2-0.0070240
161PRKCA-0.0027332
162CLK1-0.0017677

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.92164310
2Fatty acid biosynthesis_Homo sapiens_hsa000614.87663932
3Sulfur relay system_Homo sapiens_hsa041224.74890536
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.52179191
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.27089849
6Pyruvate metabolism_Homo sapiens_hsa006203.27054710
7Vitamin B6 metabolism_Homo sapiens_hsa007503.26085966
8Olfactory transduction_Homo sapiens_hsa047403.24891343
9Linoleic acid metabolism_Homo sapiens_hsa005913.15417007
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.88277497
11Glucagon signaling pathway_Homo sapiens_hsa049222.51223383
12Propanoate metabolism_Homo sapiens_hsa006402.48823068
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.48666265
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47190330
15Butanoate metabolism_Homo sapiens_hsa006502.36595890
16Allograft rejection_Homo sapiens_hsa053302.28927529
17Autoimmune thyroid disease_Homo sapiens_hsa053202.19811013
18Basal transcription factors_Homo sapiens_hsa030222.17982318
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11843667
20Type I diabetes mellitus_Homo sapiens_hsa049402.00517197
21Arginine and proline metabolism_Homo sapiens_hsa003301.98407024
22Glycerolipid metabolism_Homo sapiens_hsa005611.97034381
23Graft-versus-host disease_Homo sapiens_hsa053321.96095830
24PPAR signaling pathway_Homo sapiens_hsa033201.92540045
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.89143718
26Selenocompound metabolism_Homo sapiens_hsa004501.86464712
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.79963963
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.68959003
29Fructose and mannose metabolism_Homo sapiens_hsa000511.66472292
30Oocyte meiosis_Homo sapiens_hsa041141.60838936
31Dorso-ventral axis formation_Homo sapiens_hsa043201.56846439
32Mineral absorption_Homo sapiens_hsa049781.55188646
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54455305
34Phenylalanine metabolism_Homo sapiens_hsa003601.51533538
35Ether lipid metabolism_Homo sapiens_hsa005651.50748519
36Fatty acid degradation_Homo sapiens_hsa000711.50651143
37Fat digestion and absorption_Homo sapiens_hsa049751.49839850
38Fatty acid metabolism_Homo sapiens_hsa012121.49502236
39Amphetamine addiction_Homo sapiens_hsa050311.44692915
40Pentose phosphate pathway_Homo sapiens_hsa000301.43414387
41Viral myocarditis_Homo sapiens_hsa054161.35264625
42Carbon metabolism_Homo sapiens_hsa012001.30161074
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.28240805
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24214272
45Cardiac muscle contraction_Homo sapiens_hsa042601.21820649
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.14955922
47Base excision repair_Homo sapiens_hsa034101.14377390
48Fanconi anemia pathway_Homo sapiens_hsa034601.10620609
49Antigen processing and presentation_Homo sapiens_hsa046121.09920658
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08911232
51Hedgehog signaling pathway_Homo sapiens_hsa043401.01149488
52Renin secretion_Homo sapiens_hsa049241.00825282
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97681483
54Purine metabolism_Homo sapiens_hsa002300.96371766
55mRNA surveillance pathway_Homo sapiens_hsa030150.96110030
56Glutathione metabolism_Homo sapiens_hsa004800.94518267
57Ribosome_Homo sapiens_hsa030100.94127800
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90551801
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.88713308
60Insulin secretion_Homo sapiens_hsa049110.86128623
61Arachidonic acid metabolism_Homo sapiens_hsa005900.85637177
62Collecting duct acid secretion_Homo sapiens_hsa049660.84442255
63Biosynthesis of amino acids_Homo sapiens_hsa012300.83363265
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81790936
65Huntingtons disease_Homo sapiens_hsa050160.81438000
66RNA transport_Homo sapiens_hsa030130.80891347
67Influenza A_Homo sapiens_hsa051640.80371849
68Estrogen signaling pathway_Homo sapiens_hsa049150.78574863
69Bile secretion_Homo sapiens_hsa049760.78043975
70Thyroid hormone synthesis_Homo sapiens_hsa049180.77608338
71Arginine biosynthesis_Homo sapiens_hsa002200.76915014
72Chemical carcinogenesis_Homo sapiens_hsa052040.76595343
73Herpes simplex infection_Homo sapiens_hsa051680.73928147
74Tyrosine metabolism_Homo sapiens_hsa003500.70640511
75Long-term potentiation_Homo sapiens_hsa047200.70153166
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69741724
77Mismatch repair_Homo sapiens_hsa034300.65655537
78Notch signaling pathway_Homo sapiens_hsa043300.65018544
79Viral carcinogenesis_Homo sapiens_hsa052030.64492387
80Legionellosis_Homo sapiens_hsa051340.60190604
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.58774094
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57814310
83Alzheimers disease_Homo sapiens_hsa050100.56916127
84Renin-angiotensin system_Homo sapiens_hsa046140.56273118
85Pancreatic secretion_Homo sapiens_hsa049720.55111488
86Salivary secretion_Homo sapiens_hsa049700.53459267
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.50917358
88Protein digestion and absorption_Homo sapiens_hsa049740.50475352
89Homologous recombination_Homo sapiens_hsa034400.50221947
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50112291
91DNA replication_Homo sapiens_hsa030300.48439593
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47958930
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47900495
94ABC transporters_Homo sapiens_hsa020100.47877003
95Endocytosis_Homo sapiens_hsa041440.47855264
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.47814869
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47323266
98Acute myeloid leukemia_Homo sapiens_hsa052210.47282400
99AMPK signaling pathway_Homo sapiens_hsa041520.46484922
100Epstein-Barr virus infection_Homo sapiens_hsa051690.46118581
101Calcium signaling pathway_Homo sapiens_hsa040200.45817279
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45166570
103Nucleotide excision repair_Homo sapiens_hsa034200.45083274
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44719494
105Systemic lupus erythematosus_Homo sapiens_hsa053220.44591567
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44358192
107Peroxisome_Homo sapiens_hsa041460.44192819
108Oxidative phosphorylation_Homo sapiens_hsa001900.43048889
109Synaptic vesicle cycle_Homo sapiens_hsa047210.42959963
110Gastric acid secretion_Homo sapiens_hsa049710.42681933
111RNA polymerase_Homo sapiens_hsa030200.40412786
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40374958
113VEGF signaling pathway_Homo sapiens_hsa043700.37224435
114Inositol phosphate metabolism_Homo sapiens_hsa005620.36815073
115Parkinsons disease_Homo sapiens_hsa050120.35939575
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35805956
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35548817
118cAMP signaling pathway_Homo sapiens_hsa040240.33517121
119Metabolic pathways_Homo sapiens_hsa011000.33015358
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31746316
121Taste transduction_Homo sapiens_hsa047420.28586200
122Sulfur metabolism_Homo sapiens_hsa009200.28567560
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25966432
124Pyrimidine metabolism_Homo sapiens_hsa002400.25269459
125Phototransduction_Homo sapiens_hsa047440.24275553
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23870742
127Circadian entrainment_Homo sapiens_hsa047130.23579260
128Cocaine addiction_Homo sapiens_hsa050300.23095505
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22831197
130Alcoholism_Homo sapiens_hsa050340.22338767
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19510845
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18568056
133Retinol metabolism_Homo sapiens_hsa008300.17493157
134MAPK signaling pathway_Homo sapiens_hsa040100.16982532
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16025946
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.14526803
137Basal cell carcinoma_Homo sapiens_hsa052170.12434531
138HIF-1 signaling pathway_Homo sapiens_hsa040660.10708181
139Wnt signaling pathway_Homo sapiens_hsa043100.08839427
140B cell receptor signaling pathway_Homo sapiens_hsa046620.07177148
141RNA degradation_Homo sapiens_hsa030180.06836001
142Salmonella infection_Homo sapiens_hsa051320.06114552
143Type II diabetes mellitus_Homo sapiens_hsa049300.05632294

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