SPEM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.67182359
2motile cilium assembly (GO:0044458)9.26309354
3epithelial cilium movement (GO:0003351)9.22719449
4plasma membrane fusion (GO:0045026)9.00333486
5axonemal dynein complex assembly (GO:0070286)8.86464701
6reproduction (GO:0000003)8.77359691
7regulation of cilium movement (GO:0003352)8.62721135
8negative regulation of inclusion body assembly (GO:0090084)8.52780076
9response to pheromone (GO:0019236)7.90194240
10organic cation transport (GO:0015695)7.48493357
11spermatogenesis (GO:0007283)7.31147837
12male gamete generation (GO:0048232)7.28405591
13cilium movement (GO:0003341)7.26315773
14sperm capacitation (GO:0048240)7.23709425
15chromosome condensation (GO:0030261)7.07658426
16regulation of inclusion body assembly (GO:0090083)6.97276793
17synaptonemal complex organization (GO:0070193)6.89081135
18synaptonemal complex assembly (GO:0007130)6.86743031
19microtubule depolymerization (GO:0007019)6.85383975
20single fertilization (GO:0007338)6.83459069
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.79306182
22gamete generation (GO:0007276)6.68679133
23DNA packaging (GO:0006323)6.65244273
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.53597462
25rRNA methylation (GO:0031167)6.48478215
26phosphatidylethanolamine metabolic process (GO:0046337)6.24829950
27cilium or flagellum-dependent cell motility (GO:0001539)6.20509313
28male meiosis (GO:0007140)6.19640402
29calcium ion-dependent exocytosis (GO:0017156)6.08218123
30fertilization (GO:0009566)5.94419473
31piRNA metabolic process (GO:0034587)5.80244303
32spermatid nucleus differentiation (GO:0007289)5.78058544
33protein targeting to Golgi (GO:0000042)5.73240318
34glycerol ether metabolic process (GO:0006662)5.70193683
35sexual reproduction (GO:0019953)5.62980352
36germ cell development (GO:0007281)5.56573846
37establishment of protein localization to Golgi (GO:0072600)5.49884425
38rRNA modification (GO:0000154)5.42703583
39cellular process involved in reproduction in multicellular organism (GO:0022412)5.38459591
40cellular ketone body metabolic process (GO:0046950)5.36313515
41retrograde transport, vesicle recycling within Golgi (GO:0000301)5.30625288
42ether metabolic process (GO:0018904)5.26853043
43multicellular organismal reproductive process (GO:0048609)5.24973441
44regulation of phosphoprotein phosphatase activity (GO:0043666)5.13809821
45regulation of microtubule-based movement (GO:0060632)5.13029444
46cell recognition (GO:0008037)5.06578060
47single strand break repair (GO:0000012)5.03425117
48microtubule severing (GO:0051013)4.93766793
49positive regulation of Rab GTPase activity (GO:0032851)4.79454847
50regulation of Rab GTPase activity (GO:0032313)4.79454847
51seminiferous tubule development (GO:0072520)4.77261349
52ketone body metabolic process (GO:1902224)4.72613273
53ventricular system development (GO:0021591)4.71303940
54centriole replication (GO:0007099)4.58438757
55centriole assembly (GO:0098534)4.55564370
56chaperone-mediated protein complex assembly (GO:0051131)4.55147920
57chromosome organization involved in meiosis (GO:0070192)4.50159490
58coenzyme catabolic process (GO:0009109)4.45772176
59regulation of transcription involved in cell fate commitment (GO:0060850)4.44280594
60male meiosis I (GO:0007141)4.32197337
61sequestering of actin monomers (GO:0042989)4.26861741
62multicellular organismal development (GO:0007275)4.25379107
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24094183
64response to acidic pH (GO:0010447)4.22560982
65left/right pattern formation (GO:0060972)4.21955408
66protein localization to Golgi apparatus (GO:0034067)4.08977257
67DNA methylation involved in gamete generation (GO:0043046)3.78615705
68meiotic nuclear division (GO:0007126)3.77138033
69cellular response to pH (GO:0071467)3.63503143
70polyamine biosynthetic process (GO:0006596)3.59886794
71histone H3-K9 demethylation (GO:0033169)3.58106712
72regulation of spindle checkpoint (GO:0090231)3.54659088
73protein refolding (GO:0042026)3.52682852
74positive regulation of macrophage activation (GO:0043032)3.52675201
75protein K11-linked deubiquitination (GO:0035871)3.52556257
76regulation of centriole replication (GO:0046599)3.51777642
77microtubule polymerization or depolymerization (GO:0031109)3.50892252
78protein polyglutamylation (GO:0018095)3.50312928
79negative regulation of Rho protein signal transduction (GO:0035024)3.43141905
80chromatin silencing (GO:0006342)3.41899020
81meiosis I (GO:0007127)3.41501687
82histone exchange (GO:0043486)3.39101430
83glycolytic process (GO:0006096)3.37026094
84interferon-gamma secretion (GO:0072643)3.33764993
85cranial nerve morphogenesis (GO:0021602)3.33183612
86nucleus organization (GO:0006997)3.31148022
87RNA destabilization (GO:0050779)3.30452952
88genitalia morphogenesis (GO:0035112)3.28158110
89musculoskeletal movement (GO:0050881)3.25050785
90multicellular organismal movement (GO:0050879)3.25050785
91mitotic sister chromatid cohesion (GO:0007064)3.24174403
92RNA localization (GO:0006403)3.23872729
93peptidyl-threonine dephosphorylation (GO:0035970)3.23790463
94mitochondrion degradation (GO:0000422)3.14693437
95amino-acid betaine transport (GO:0015838)3.13626592
96carnitine transport (GO:0015879)3.13626592
97cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.11167973
98cellular biogenic amine biosynthetic process (GO:0042401)3.08175108
99regulation of ARF GTPase activity (GO:0032312)3.04202592
100membrane protein intracellular domain proteolysis (GO:0031293)3.03352885
101nucleoside diphosphate phosphorylation (GO:0006165)2.96649804
102amine biosynthetic process (GO:0009309)2.96226600
103meiotic cell cycle (GO:0051321)2.95045223
104homeostasis of number of cells within a tissue (GO:0048873)2.92880781
105regulation of cilium assembly (GO:1902017)2.92724512
106cerebral cortex neuron differentiation (GO:0021895)2.91683329
107carnitine transmembrane transport (GO:1902603)2.90770505
108detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.85068840
109regulation of interleukin-13 production (GO:0032656)2.82387968
110polyol catabolic process (GO:0046174)2.79778032
111positive regulation of glycolytic process (GO:0045821)2.79226122
112alditol metabolic process (GO:0019400)2.77490772
113male sex determination (GO:0030238)2.75081386
114receptor recycling (GO:0001881)2.74967628
115regulation of T-helper 2 cell differentiation (GO:0045628)2.71922479
116protein localization to cilium (GO:0061512)2.70175662
117protein-DNA complex disassembly (GO:0032986)2.69254659
118nucleosome disassembly (GO:0006337)2.69254659
119GTP biosynthetic process (GO:0006183)2.66099347
120DNA conformation change (GO:0071103)2.64718438
121regulation of somitogenesis (GO:0014807)2.62763224
122negative regulation of gene expression, epigenetic (GO:0045814)2.61332302
123meiotic cell cycle process (GO:1903046)2.55298999
124cilium organization (GO:0044782)2.45354677
125synapsis (GO:0007129)2.43657599
126peptidyl-glutamic acid modification (GO:0018200)2.42937880
127cellular component assembly involved in morphogenesis (GO:0010927)2.42099152
128cilium morphogenesis (GO:0060271)2.38788804
129microtubule-based movement (GO:0007018)2.38511495
130UTP biosynthetic process (GO:0006228)2.38176486
131protein depolymerization (GO:0051261)2.38050081
132protein localization to chromosome, centromeric region (GO:0071459)2.37015795
133* sperm motility (GO:0030317)14.1013333
134cell wall macromolecule catabolic process (GO:0016998)13.6123903
135cell wall macromolecule metabolic process (GO:0044036)13.6123903
136acrosome reaction (GO:0007340)13.3615787
137fusion of sperm to egg plasma membrane (GO:0007342)11.8192132
138sperm-egg recognition (GO:0035036)11.5658139
139acrosome assembly (GO:0001675)11.5616651
140binding of sperm to zona pellucida (GO:0007339)10.6961925
141cell-cell recognition (GO:0009988)10.3549782
142spermatid development (GO:0007286)10.1884612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.33816046
2EZH2_22144423_ChIP-Seq_EOC_Human4.36158117
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.98021520
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66572717
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.47035625
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.37390319
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.17601389
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.95854319
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.91154611
10VDR_22108803_ChIP-Seq_LS180_Human2.75815681
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.70423760
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.56331054
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50113657
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25110604
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24058301
16ZNF274_21170338_ChIP-Seq_K562_Hela2.09565029
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08370639
18FUS_26573619_Chip-Seq_HEK293_Human2.07625845
19ERA_21632823_ChIP-Seq_H3396_Human2.06947821
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03957000
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01707558
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01188239
23* NANOG_20526341_ChIP-Seq_ESCs_Human1.97795262
24* RAC3_21632823_ChIP-Seq_H3396_Human1.91199218
25FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90972152
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.89462564
27SOX2_22085726_ChIP-Seq_NPCs_Mouse1.82815172
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81974031
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.78038841
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76954945
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.74390726
32STAT1_17558387_ChIP-Seq_HELA_Human1.67096199
33OCT4_20526341_ChIP-Seq_ESCs_Human1.66031002
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65507717
35FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64528632
36ER_23166858_ChIP-Seq_MCF-7_Human1.63527284
37E2F1_20622854_ChIP-Seq_HELA_Human1.63128810
38* GATA3_21867929_ChIP-Seq_CD8_Mouse1.61354532
39TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60212291
40DROSHA_22980978_ChIP-Seq_HELA_Human1.59415258
41PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57997292
42LXR_22292898_ChIP-Seq_THP-1_Human1.56939113
43* MYC_19829295_ChIP-Seq_ESCs_Human1.55159614
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.53819216
45* P68_20966046_ChIP-Seq_HELA_Human1.52861664
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52575138
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49499083
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48216384
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47937372
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.47922436
51GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47728999
52P53_21459846_ChIP-Seq_SAOS-2_Human1.46488472
53P300_27268052_Chip-Seq_Bcells_Human1.44855146
54REST_21632747_ChIP-Seq_MESCs_Mouse1.44830529
55* TP63_22573176_ChIP-Seq_HFKS_Human1.42005061
56TP53_18474530_ChIP-ChIP_U2OS_Human1.41843909
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.40936071
58SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.40519638
59LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38690382
60AR_25329375_ChIP-Seq_VCAP_Human1.36733632
61KDM2B_26808549_Chip-Seq_REH_Human1.35824008
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35729714
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.35205618
64RAD21_21589869_ChIP-Seq_MESCs_Mouse1.35203628
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.33073241
66SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32962095
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32452092
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32298260
69CBP_20019798_ChIP-Seq_JUKART_Human1.32298260
70CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31856697
71* TAF2_19829295_ChIP-Seq_ESCs_Human1.30692920
72HNFA_21074721_ChIP-Seq_CACO-2_Human1.30556288
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30318575
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.28854437
75GF1_26923725_Chip-Seq_HPCs_Mouse1.28479198
76TBL1_22424771_ChIP-Seq_293T_Human1.27373031
77AR_21572438_ChIP-Seq_LNCaP_Human1.27340608
78CBX2_22325352_ChIP-Seq_293T-Rex_Human1.26994818
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26670901
80RBPJ_21746931_ChIP-Seq_IB4_Human1.25762743
81MYC_27129775_Chip-Seq_CORNEA_Mouse1.24776286
82CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24710761
83SMAD3_21741376_ChIP-Seq_ESCs_Human1.24468308
84* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24261280
85P300_19829295_ChIP-Seq_ESCs_Human1.24224127
86JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.24137810
87SPI1_26923725_Chip-Seq_HPCs_Mouse1.23936043
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23042557
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.23015540
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22991128
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22792965
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22648140
93GATA1_19941827_ChIP-Seq_MEL86_Mouse1.21798736
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20801339
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19217243
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19161641
97ETV1_20927104_ChIP-Seq_GIST48_Human1.17974642
98CTCF_20526341_ChIP-Seq_ESCs_Human1.17719351
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17519877
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16338004
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16280238
102* GATA3_21867929_ChIP-Seq_TH1_Mouse1.16159715
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16011042
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.15262387
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.14723530
106RUNX2_22187159_ChIP-Seq_PCA_Human1.14009599
107* OCT1_27270436_Chip-Seq_PROSTATE_Human1.13377399
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13172054
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13057910
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13057910
111ERG_20517297_ChIP-Seq_VCAP_Human1.12982293
112RARA_24833708_ChIP-Seq_LIVER_Mouse1.12092987
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.12026947
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11853012
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10380130
116SOX2_19829295_ChIP-Seq_ESCs_Human1.10263872
117NANOG_19829295_ChIP-Seq_ESCs_Human1.10263872
118SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10094921
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09211833
120PHF8_20622853_ChIP-Seq_HELA_Human1.09079337
121ESET_19884257_ChIP-Seq_ESCs_Mouse1.09043329
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08211150
123SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07643972
124SPI1_20517297_ChIP-Seq_HL60_Human1.07533348
125KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07270214
126SOX11_22085726_ChIP-Seq_ESNs_Mouse1.06286379
127CEBPB_22108803_ChIP-Seq_LS180_Human1.05605570
128ELF1_20517297_ChIP-Seq_JURKAT_Human1.05319644
129RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04751994
130* BCOR_27268052_Chip-Seq_Bcells_Human1.04148061
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03992598
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03808774
133SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03748167
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03629531
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03467862
136GATA6_21074721_ChIP-Seq_CACO-2_Human1.03420579
137SMAD4_21741376_ChIP-Seq_HESCs_Human1.03141755
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02736023
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02471430
140HOXB7_26014856_ChIP-Seq_BT474_Human1.02082878
141SMAD4_21799915_ChIP-Seq_A2780_Human1.01711182
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00867196
143SA1_27219007_Chip-Seq_Bcells_Human1.00788122
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99701229
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99426103
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.99310658
147OCT4_19829295_ChIP-Seq_ESCs_Human0.98599157
148FOXH1_21741376_ChIP-Seq_ESCs_Human0.98541300
149AHR_22903824_ChIP-Seq_MCF-7_Human0.98474128
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98465857
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.98379373
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.95968650
153ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95678471
154SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95092053
155NFE2_27457419_Chip-Seq_LIVER_Mouse0.93141515
156TAF15_26573619_Chip-Seq_HEK293_Human0.93122374
157* BCL6_27268052_Chip-Seq_Bcells_Human0.92847986
158PHF8_20622854_ChIP-Seq_HELA_Human0.92351434
159* CTCF_27219007_Chip-Seq_Bcells_Human0.91978551
160CSB_26484114_Chip-Seq_FIBROBLAST_Human0.91092501
161SMC4_20622854_ChIP-Seq_HELA_Human0.89886316
162NFYB_21822215_ChIP-Seq_K562_Human0.89415438
163KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87886362
164NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87195340
165PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86997841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.06059430
2* MP0001929_abnormal_gametogenesis5.51546758
3MP0005670_abnormal_white_adipose3.51621915
4MP0008877_abnormal_DNA_methylation3.46302198
5* MP0002161_abnormal_fertility/fecundity3.31274431
6MP0002210_abnormal_sex_determination3.19357718
7MP0001145_abnormal_male_reproductive2.72763268
8MP0000678_abnormal_parathyroid_gland2.52839499
9MP0002132_abnormal_respiratory_system2.48612629
10MP0000653_abnormal_sex_gland2.33679950
11MP0003718_maternal_effect2.26430099
12* MP0005410_abnormal_fertilization16.7701705
13MP0004233_abnormal_muscle_weight1.75527933
14MP0002249_abnormal_larynx_morphology1.68708085
15MP0008004_abnormal_stomach_pH1.66843691
16MP0005423_abnormal_somatic_nervous1.64274374
17MP0003315_abnormal_perineum_morphology1.63835458
18MP0002653_abnormal_ependyma_morphology1.60584534
19MP0003646_muscle_fatigue1.59522047
20MP0001485_abnormal_pinna_reflex1.36441147
21MP0002160_abnormal_reproductive_system1.33755114
22MP0002234_abnormal_pharynx_morphology1.33341725
23MP0005379_endocrine/exocrine_gland_phen1.29027775
24MP0001486_abnormal_startle_reflex1.26818388
25MP0002127_abnormal_cardiovascular_syste1.20823575
26MP0005248_abnormal_Harderian_gland1.19760900
27MP0005395_other_phenotype1.17090246
28MP0001984_abnormal_olfaction1.16934799
29MP0001765_abnormal_ion_homeostasis1.10202218
30MP0004859_abnormal_synaptic_plasticity1.09772363
31MP0002138_abnormal_hepatobiliary_system1.08460567
32MP0001905_abnormal_dopamine_level1.08284593
33MP0002735_abnormal_chemical_nociception1.07837955
34MP0009053_abnormal_anal_canal1.07753102
35MP0005623_abnormal_meninges_morphology1.00411611
36MP0001963_abnormal_hearing_physiology1.00397488
37MP0004510_myositis0.95432126
38MP0000026_abnormal_inner_ear0.94329528
39MP0002282_abnormal_trachea_morphology0.91079677
40MP0004085_abnormal_heartbeat0.86901836
41MP0003136_yellow_coat_color0.86545085
42MP0005310_abnormal_salivary_gland0.85304493
43MP0000681_abnormal_thyroid_gland0.80281116
44MP0000049_abnormal_middle_ear0.80066644
45MP0003329_amyloid_beta_deposits0.79361549
46MP0005451_abnormal_body_composition0.78037891
47MP0003115_abnormal_respiratory_system0.77101208
48MP0002736_abnormal_nociception_after0.76536595
49MP0009697_abnormal_copulation0.74870355
50MP0000955_abnormal_spinal_cord0.74567251
51MP0010386_abnormal_urinary_bladder0.72611001
52MP0005666_abnormal_adipose_tissue0.69273762
53MP0003011_delayed_dark_adaptation0.68185340
54MP0002067_abnormal_sensory_capabilities0.68104229
55MP0005394_taste/olfaction_phenotype0.65670741
56MP0005499_abnormal_olfactory_system0.65670741
57MP0005636_abnormal_mineral_homeostasis0.64986994
58MP0001879_abnormal_lymphatic_vessel0.63819994
59MP0000470_abnormal_stomach_morphology0.63742010
60MP0010368_abnormal_lymphatic_system0.63204173
61MP0002557_abnormal_social/conspecific_i0.62644725
62MP0005647_abnormal_sex_gland0.62112825
63MP0005083_abnormal_biliary_tract0.62051307
64MP0004036_abnormal_muscle_relaxation0.61701159
65MP0009046_muscle_twitch0.60929050
66MP0003936_abnormal_reproductive_system0.60738709
67MP0005389_reproductive_system_phenotype0.59940539
68MP0002269_muscular_atrophy0.58456155
69MP0003045_fibrosis0.57842968
70MP0000534_abnormal_ureter_morphology0.57593423
71MP0005360_urolithiasis0.57515838
72MP0004484_altered_response_of0.57451026
73MP0001188_hyperpigmentation0.57356289
74MP0001764_abnormal_homeostasis0.53338630
75MP0008058_abnormal_DNA_repair0.52731377
76MP0001501_abnormal_sleep_pattern0.52056196
77MP0001324_abnormal_eye_pigmentation0.50622263
78MP0006036_abnormal_mitochondrial_physio0.50030885
79MP0003878_abnormal_ear_physiology0.48453886
80MP0005377_hearing/vestibular/ear_phenot0.48453886
81MP0001968_abnormal_touch/_nociception0.47806554
82MP0005367_renal/urinary_system_phenotyp0.46602578
83MP0000516_abnormal_urinary_system0.46602578
84MP0003077_abnormal_cell_cycle0.46572308
85MP0002733_abnormal_thermal_nociception0.46441067
86MP0001270_distended_abdomen0.46079100
87MP0008995_early_reproductive_senescence0.46063979
88MP0002168_other_aberrant_phenotype0.45085756
89MP0001666_abnormal_nutrient_absorption0.44686788
90MP0003119_abnormal_digestive_system0.44554878
91MP0009745_abnormal_behavioral_response0.43806996
92MP0000230_abnormal_systemic_arterial0.43301215
93MP0005167_abnormal_blood-brain_barrier0.43160192
94MP0000604_amyloidosis0.43019013
95MP0005551_abnormal_eye_electrophysiolog0.41502940
96MP0003699_abnormal_female_reproductive0.41432344
97MP0001970_abnormal_pain_threshold0.41140267
98MP0000358_abnormal_cell_content/0.40117713
99MP0002139_abnormal_hepatobiliary_system0.39768216
100MP0001664_abnormal_digestion0.39498253
101MP0005253_abnormal_eye_physiology0.39460061
102MP0003942_abnormal_urinary_system0.39065112
103MP0004133_heterotaxia0.38936330
104MP0001293_anophthalmia0.38886772
105MP0004811_abnormal_neuron_physiology0.37729709
106MP0004084_abnormal_cardiac_muscle0.37329664
107MP0009115_abnormal_fat_cell0.36567197
108MP0005397_hematopoietic_system_phenotyp0.36452894
109MP0001545_abnormal_hematopoietic_system0.36452894
110MP0009278_abnormal_bone_marrow0.35716923
111MP0003633_abnormal_nervous_system0.32398932
112MP0004145_abnormal_muscle_electrophysio0.30423248
113MP0002909_abnormal_adrenal_gland0.30326810
114MP0002928_abnormal_bile_duct0.30324589
115MP0000569_abnormal_digit_pigmentation0.30308910
116MP0002169_no_abnormal_phenotype0.29468475
117MP0004270_analgesia0.29360406
118MP0002873_normal_phenotype0.29281991
119MP0001849_ear_inflammation0.29065240
120MP0003879_abnormal_hair_cell0.28484287
121MP0003631_nervous_system_phenotype0.27430548
122MP0003948_abnormal_gas_homeostasis0.27410039
123MP0005391_vision/eye_phenotype0.27274532
124MP0003950_abnormal_plasma_membrane0.26270041
125MP0003861_abnormal_nervous_system0.26199847
126MP0001730_embryonic_growth_arrest0.25897547
127MP0000751_myopathy0.25772127
128MP0002152_abnormal_brain_morphology0.25684408
129MP0002971_abnormal_brown_adipose0.25336426
130MP0005375_adipose_tissue_phenotype0.25116000
131MP0003787_abnormal_imprinting0.24366682
132MP0004742_abnormal_vestibular_system0.24086723
133MP0002295_abnormal_pulmonary_circulatio0.24067622
134MP0008569_lethality_at_weaning0.23788088
135MP0000462_abnormal_digestive_system0.23734975
136MP0006035_abnormal_mitochondrial_morpho0.23077562
137MP0008875_abnormal_xenobiotic_pharmacok0.22090875
138MP0003806_abnormal_nucleotide_metabolis0.21860139
139MP0004043_abnormal_pH_regulation0.21572848
140MP0002822_catalepsy0.21120392
141MP0002272_abnormal_nervous_system0.20306988
142MP0003959_abnormal_lean_body0.19369816
143MP0003635_abnormal_synaptic_transmissio0.19261922
144MP0005365_abnormal_bile_salt0.18200990
145MP0002229_neurodegeneration0.17694150
146MP0001348_abnormal_lacrimal_gland0.17516834
147MP0000001_mammalian_phenotype0.17013406
148MP0004019_abnormal_vitamin_homeostasis0.16498542
149MP0002063_abnormal_learning/memory/cond0.16364613
150MP0002693_abnormal_pancreas_physiology0.16276156
151MP0002572_abnormal_emotion/affect_behav0.16155164
152MP0002118_abnormal_lipid_homeostasis0.16129342
153MP0000920_abnormal_myelination0.15979812
154MP0005319_abnormal_enzyme/_coenzyme0.15122218
155MP0008770_decreased_survivor_rate0.14708828
156MP0002106_abnormal_muscle_physiology0.14424913
157MP0004087_abnormal_muscle_fiber0.13893767
158MP0003632_abnormal_nervous_system0.13839904

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.20634728
2Abnormal respiratory motile cilium morphology (HP:0005938)9.18252568
3Abnormal respiratory epithelium morphology (HP:0012253)9.18252568
4Infertility (HP:0000789)7.50051781
5Severe visual impairment (HP:0001141)7.49434819
6Chronic bronchitis (HP:0004469)7.38902063
7Rhinitis (HP:0012384)7.17236886
8Abnormal ciliary motility (HP:0012262)6.98309339
9Nasal polyposis (HP:0100582)6.43029054
10Resting tremor (HP:0002322)6.09671882
11Male infertility (HP:0003251)5.30730283
12Abnormality of the nasal mucosa (HP:0000433)5.29502095
13Attenuation of retinal blood vessels (HP:0007843)5.05155602
14Bony spicule pigmentary retinopathy (HP:0007737)5.03495232
15Bronchitis (HP:0012387)4.49962842
16Bronchiectasis (HP:0002110)4.23346946
17Chronic hepatic failure (HP:0100626)4.09817957
18Abnormal rod and cone electroretinograms (HP:0008323)4.08838410
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.07915892
20Postural instability (HP:0002172)3.89724616
21Hyperkalemia (HP:0002153)3.87492147
22Abnormality of macular pigmentation (HP:0008002)3.84918916
23Abnormal spermatogenesis (HP:0008669)3.84559311
24Nephronophthisis (HP:0000090)3.80147807
25Facial shape deformation (HP:0011334)3.55238175
26Potter facies (HP:0002009)3.55238175
27Hypoplastic ischia (HP:0003175)3.38186197
28Enlarged epiphyses (HP:0010580)3.20855043
29Recurrent otitis media (HP:0000403)3.19565626
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.06343926
31Abnormality of the ischium (HP:0003174)3.04853654
32Cone-rod dystrophy (HP:0000548)3.00588749
33Abnormal gallbladder physiology (HP:0012438)2.98915446
34Cholecystitis (HP:0001082)2.98915446
35Recurrent sinusitis (HP:0011108)2.94002547
36Hypoplasia of the thymus (HP:0000778)2.83383108
37Abnormality of the renal medulla (HP:0100957)2.79385365
38Abnormal sex determination (HP:0012244)2.76494034
39Sex reversal (HP:0012245)2.76494034
40Impulsivity (HP:0100710)2.71034408
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.70856341
42Recurrent bronchitis (HP:0002837)2.57336695
43Tubular atrophy (HP:0000092)2.54208069
44Hypoalphalipoproteinemia (HP:0003233)2.52369888
45Unilateral renal agenesis (HP:0000122)2.48310283
46Tubulointerstitial nephritis (HP:0001970)2.48225626
47Congenital malformation of the right heart (HP:0011723)2.47100204
48Double outlet right ventricle (HP:0001719)2.47100204
49Generalized aminoaciduria (HP:0002909)2.46740674
50Progressive sensorineural hearing impairment (HP:0000408)2.42890866
51Dyschromatopsia (HP:0007641)2.41885200
52Flattened epiphyses (HP:0003071)2.41358192
53Abnormality of the aortic arch (HP:0012303)2.37335545
54Molar tooth sign on MRI (HP:0002419)2.37200658
55Abnormality of midbrain morphology (HP:0002418)2.37200658
56Abnormality of dental color (HP:0011073)2.36817921
57Choroideremia (HP:0001139)2.35024881
58Tubulointerstitial abnormality (HP:0001969)2.33430715
59Polyuria (HP:0000103)2.26655437
60Abnormality of potassium homeostasis (HP:0011042)2.25420289
61Azoospermia (HP:0000027)2.24804497
62Abnormality of the costochondral junction (HP:0000919)2.22699493
63Progressive cerebellar ataxia (HP:0002073)2.19127814
64Optic nerve hypoplasia (HP:0000609)2.16612476
65Decreased central vision (HP:0007663)2.15549733
66Neurofibrillary tangles (HP:0002185)2.13104886
67Medial flaring of the eyebrow (HP:0010747)2.11883686
68Occipital encephalocele (HP:0002085)2.11694350
69Renovascular hypertension (HP:0100817)2.11599809
70Congenital sensorineural hearing impairment (HP:0008527)2.10024557
71Epiphyseal dysplasia (HP:0002656)2.09916888
72Portal hypertension (HP:0001409)2.06429680
73Amelogenesis imperfecta (HP:0000705)2.06243933
74Tubulointerstitial fibrosis (HP:0005576)2.05809728
75Gonadotropin excess (HP:0000837)2.05681194
76Hemorrhage of the eye (HP:0011885)2.05098437
77Abnormality of the hepatic vasculature (HP:0006707)2.02952054
78Widely patent fontanelles and sutures (HP:0004492)2.01338605
79Spastic tetraparesis (HP:0001285)2.00562699
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.3419806
81Absent/shortened dynein arms (HP:0200106)13.3419806
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5750048
83Insulin-resistant diabetes mellitus (HP:0000831)1.95619620
84Recurrent corneal erosions (HP:0000495)1.93872000
85Exercise-induced myalgia (HP:0003738)1.92526145
86Menstrual irregularities (HP:0000858)1.91314019
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90510447
88Hypophosphatemic rickets (HP:0004912)1.88268435
89Gonadal dysgenesis (HP:0000133)1.85993170
90Colitis (HP:0002583)1.84136512
91Atonic seizures (HP:0010819)1.84042292
92Hypoplasia of the uterus (HP:0000013)1.83886722
93Hyponatremia (HP:0002902)1.79138266
94Abnormal drinking behavior (HP:0030082)1.77707417
95Polydipsia (HP:0001959)1.77707417
96Photophobia (HP:0000613)1.76639236
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75139580
98Cerebral inclusion bodies (HP:0100314)1.74090556
99Osteomalacia (HP:0002749)1.74052176
100Myoglobinuria (HP:0002913)1.73952426
101Tetany (HP:0001281)1.73077468
102Anterior segment dysgenesis (HP:0007700)1.72971192
103Abnormality of the parathyroid morphology (HP:0011766)1.72614307
104Type II lissencephaly (HP:0007260)1.72132289
105Male pseudohermaphroditism (HP:0000037)1.71620797
106Ventricular tachycardia (HP:0004756)1.70301744
107Hyperuricemia (HP:0002149)1.68330141
108Increased purine levels (HP:0004368)1.68330141
109Abnormal biliary tract physiology (HP:0012439)1.66608378
110Bile duct proliferation (HP:0001408)1.66608378
111Abnormality of renal excretion (HP:0011036)1.62368048
112Stage 5 chronic kidney disease (HP:0003774)1.61150516
113Heterotopia (HP:0002282)1.61108276
114Sensory axonal neuropathy (HP:0003390)1.60857943
115Easy fatigability (HP:0003388)1.60065345
116Exercise-induced muscle cramps (HP:0003710)1.57736437
117Rhabdomyolysis (HP:0003201)1.57006052
118Bundle branch block (HP:0011710)1.56772609
119Aplasia/Hypoplasia of the lens (HP:0008063)1.56768832
120Asymmetric septal hypertrophy (HP:0001670)1.53736236
121Neoplasm of the heart (HP:0100544)1.53022654
122Hypercholesterolemia (HP:0003124)1.52630567
123Abnormality of the neuromuscular junction (HP:0003398)1.50321280
124Fatigable weakness (HP:0003473)1.50321280
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.49797490
126Postaxial foot polydactyly (HP:0001830)1.49442941
127Loss of speech (HP:0002371)1.47905745
128Congenital hepatic fibrosis (HP:0002612)1.46907941
129Abnormal urine output (HP:0012590)1.45384299
130Constricted visual fields (HP:0001133)1.43475658
131Bell-shaped thorax (HP:0001591)1.41691105
132Abnormality of the renal cortex (HP:0011035)1.38251048
133Short ribs (HP:0000773)1.36087519
134Oculomotor apraxia (HP:0000657)1.35670820
135Abnormality of dentin (HP:0010299)1.32691674
136Decreased muscle mass (HP:0003199)1.32338116
137Transposition of the great arteries (HP:0001669)1.32124727
138Abnormal connection of the cardiac segments (HP:0011545)1.32124727
139Abnormal ventriculo-arterial connection (HP:0011563)1.32124727
140Cerebellar dysplasia (HP:0007033)1.31703817
141Generalized muscle weakness (HP:0003324)1.30498490
142Renal dysplasia (HP:0000110)1.29906456
143Hemiparesis (HP:0001269)1.28494674
144Aplasia/Hypoplasia affecting the retina (HP:0008061)1.28344989
145Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.26346398
146Type 2 muscle fiber atrophy (HP:0003554)1.25558468
147Postaxial hand polydactyly (HP:0001162)1.25176634
148Retinal dysplasia (HP:0007973)1.24463152
149Bulbar palsy (HP:0001283)1.23641628
150Broad distal phalanx of finger (HP:0009836)1.23623741
151Deformed sella turcica (HP:0002681)1.22613390
152Abnormality of the dental root (HP:0006486)1.21157491
153Taurodontia (HP:0000679)1.21157491
154Abnormality of permanent molar morphology (HP:0011071)1.21157491
155Polymicrogyria (HP:0002126)1.20304290
156Cystic liver disease (HP:0006706)1.19513121
157Facial cleft (HP:0002006)1.19084848
158Truncal obesity (HP:0001956)1.18740430
159Short femoral neck (HP:0100864)1.17937891
160Absent epiphyses (HP:0010577)1.16470992
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.16470992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK17.50990915
2PDK37.30172977
3PDK47.30172977
4PLK47.04909469
5PRKD35.53139675
6ICK5.32017592
7PDK24.69273487
8DDR24.42112583
9INSRR3.07409217
10MAP4K22.97524739
11BRD42.48567891
12PLK22.40647324
13STK382.20838519
14PTK2B2.19263310
15WNK42.12467480
16MST1R2.08823894
17STK392.08478497
18DYRK1B1.94206272
19TLK11.59363322
20NEK21.51792357
21ZAK1.50876641
22PDK11.43783128
23LATS11.43392899
24MAP3K91.32380574
25PNCK1.32009118
26LATS21.21774700
27PIK3CG1.20229994
28CDK121.18997782
29PDPK11.07658554
30CDK71.07329873
31RIPK41.06181641
32MYLK1.04921448
33KSR21.02217446
34RPS6KA50.99067783
35DYRK30.96966633
36CDK30.95927040
37EEF2K0.88658155
38MAPK150.87489962
39IRAK10.87453887
40TYRO30.85886211
41SGK4940.77625083
42SGK2230.77625083
43WNK10.75521380
44CCNB10.70062731
45ROCK10.70001849
46AKT30.69667508
47TESK20.68414328
48PINK10.67546137
49PASK0.66474797
50CAMK1D0.66034532
51NTRK20.63265542
52ARAF0.62388761
53RPS6KA20.62354817
54CAMK10.60620693
55BMPR1B0.58647502
56SIK20.57248945
57MUSK0.57115073
58CHEK20.54828265
59TTK0.54678686
60IRAK20.52323065
61MAP3K100.51115077
62PRKCG0.50767927
63UHMK10.50483652
64STK30.49796639
65MAP3K20.49198694
66MAP2K60.48471328
67MAP3K80.48453604
68PRKAA20.45149022
69PAK10.43393666
70MAP2K70.42049380
71STK38L0.41945117
72MAP2K20.40563509
73MAPK10.39837695
74MAPKAPK50.36893263
75LMTK20.35325943
76PAK40.35151234
77CDK40.34746758
78FRK0.34473378
79CAMK1G0.33672643
80MARK20.33584101
81PAK20.33387535
82CAMKK10.32377727
83TIE10.30731391
84PRKCZ0.29702322
85RPS6KC10.29119777
86RPS6KL10.29119777
87MET0.29017054
88MAP3K110.28620189
89CDK150.28231058
90CHEK10.28124253
91RPS6KA60.25886165
92CDK180.25204707
93CAMK40.25081199
94CDK11A0.23124452
95MAP3K130.23037860
96PRKCQ0.22474468
97SGK10.20772642
98MTOR0.20255406
99DYRK20.19554967
100CDK140.19046528
101PRKG20.18529110
102OBSCN0.17858875
103ATM0.17702377
104TNIK0.17526243
105VRK10.17482081
106PRKAA10.16671061
107BRAF0.16495306
108MAPK100.15427116
109MAPK140.14458605
110CDK50.13925435
111BRSK10.13598402
112ADRBK20.13345568
113BRSK20.12682830
114AKT10.12677960
115CSF1R0.12563324
116RPS6KA10.12033049
117PAK60.11795687
118CLK10.10570431
119MOS0.10450576
120ATR0.10253160
121RPS6KB10.10196016
122PRKCD0.09532764
123STK100.08654902
124CSNK2A10.06791731
125GSK3B0.06759153
126CAMK2A0.06513803
127NEK60.06041385
128STK110.05427227
129PRKCA0.04075025
130TRIB30.04046640
131PIM10.03977849
132PRKACG0.03767195
133PRKCB0.03282078
134MAPK80.03128529
135PKN10.02646370
136PLK10.02569421
137CDK60.02364448
138PRKG10.02172671
139MAP3K10.02030234
140EPHB10.01450767
141MARK30.01314568
142MINK1-0.0669161
143YES1-0.0619321
144IGF1R-0.0521401
145PRKACB-0.0468922
146SRC-0.0459763
147CSNK1D-0.0451457
148MAP3K4-0.0435865
149PDGFRB-0.0334978
150PRKACA-0.0282632
151EGFR-0.0223371
152RPS6KA3-0.0197392
153CSNK2A2-0.0134302
154CDK2-0.0086936
155CDK1-0.0042547
156MARK1-0.0035615
157AURKA-0.0026048

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.14425240
2Fatty acid biosynthesis_Homo sapiens_hsa000615.25932293
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.45177832
4Olfactory transduction_Homo sapiens_hsa047403.73611305
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.45636499
6Linoleic acid metabolism_Homo sapiens_hsa005913.35028443
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.22353545
8Pyruvate metabolism_Homo sapiens_hsa006202.91982736
9Vitamin B6 metabolism_Homo sapiens_hsa007502.80801124
10Butanoate metabolism_Homo sapiens_hsa006502.80710094
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.60100939
12Glucagon signaling pathway_Homo sapiens_hsa049222.42381486
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28444584
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.13623912
15Propanoate metabolism_Homo sapiens_hsa006402.12873754
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.09185747
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05879530
18Gap junction_Homo sapiens_hsa045401.99152561
19PPAR signaling pathway_Homo sapiens_hsa033201.90330020
20Glycerolipid metabolism_Homo sapiens_hsa005611.86488473
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.84520455
22Fat digestion and absorption_Homo sapiens_hsa049751.81523327
23Basal transcription factors_Homo sapiens_hsa030221.80835664
24Arginine biosynthesis_Homo sapiens_hsa002201.75681631
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74912385
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.73636269
27Fructose and mannose metabolism_Homo sapiens_hsa000511.70971111
28Selenocompound metabolism_Homo sapiens_hsa004501.68863360
29Fatty acid degradation_Homo sapiens_hsa000711.67870462
30Mineral absorption_Homo sapiens_hsa049781.65351166
31Fatty acid metabolism_Homo sapiens_hsa012121.64854494
32Ether lipid metabolism_Homo sapiens_hsa005651.62750989
33Phenylalanine metabolism_Homo sapiens_hsa003601.60408291
34Amphetamine addiction_Homo sapiens_hsa050311.55813185
35Nitrogen metabolism_Homo sapiens_hsa009101.44643458
36Cardiac muscle contraction_Homo sapiens_hsa042601.39634019
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38996680
38Carbon metabolism_Homo sapiens_hsa012001.32388724
39Oocyte meiosis_Homo sapiens_hsa041141.31852769
40Type I diabetes mellitus_Homo sapiens_hsa049401.28376530
41Graft-versus-host disease_Homo sapiens_hsa053321.21769603
42Allograft rejection_Homo sapiens_hsa053301.21713607
43Pentose phosphate pathway_Homo sapiens_hsa000301.21198412
44Autoimmune thyroid disease_Homo sapiens_hsa053201.19127061
45Hedgehog signaling pathway_Homo sapiens_hsa043401.13791599
46Collecting duct acid secretion_Homo sapiens_hsa049661.13346871
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11861604
48Glutathione metabolism_Homo sapiens_hsa004801.08847490
49Renin secretion_Homo sapiens_hsa049241.06058525
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04859080
51Insulin secretion_Homo sapiens_hsa049111.02911107
52Arginine and proline metabolism_Homo sapiens_hsa003301.02213169
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.96055272
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.95460447
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94935096
56Dorso-ventral axis formation_Homo sapiens_hsa043200.94485813
57Arachidonic acid metabolism_Homo sapiens_hsa005900.93464794
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.92883797
59Phagosome_Homo sapiens_hsa041450.92411875
60Antigen processing and presentation_Homo sapiens_hsa046120.91543969
61Chemical carcinogenesis_Homo sapiens_hsa052040.89819478
62Bile secretion_Homo sapiens_hsa049760.88607423
63Purine metabolism_Homo sapiens_hsa002300.87224345
64Phototransduction_Homo sapiens_hsa047440.85897554
65Thyroid hormone synthesis_Homo sapiens_hsa049180.85011239
66Biosynthesis of amino acids_Homo sapiens_hsa012300.82610825
67Long-term potentiation_Homo sapiens_hsa047200.82354237
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80154882
69Viral myocarditis_Homo sapiens_hsa054160.80086563
70Estrogen signaling pathway_Homo sapiens_hsa049150.78285684
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78095484
72Salivary secretion_Homo sapiens_hsa049700.70876565
73Tyrosine metabolism_Homo sapiens_hsa003500.68916889
74Pancreatic secretion_Homo sapiens_hsa049720.68862840
75Apoptosis_Homo sapiens_hsa042100.67872463
76Synaptic vesicle cycle_Homo sapiens_hsa047210.66086383
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.63548954
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.62141298
79Morphine addiction_Homo sapiens_hsa050320.61559533
80mRNA surveillance pathway_Homo sapiens_hsa030150.58673122
81Influenza A_Homo sapiens_hsa051640.58458978
82Legionellosis_Homo sapiens_hsa051340.56842395
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.55721459
84Systemic lupus erythematosus_Homo sapiens_hsa053220.55440773
85Gastric acid secretion_Homo sapiens_hsa049710.54580665
86Huntingtons disease_Homo sapiens_hsa050160.54224213
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53994030
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53096959
89Nicotine addiction_Homo sapiens_hsa050330.53003469
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51169197
91Retinol metabolism_Homo sapiens_hsa008300.50317004
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49819139
93Protein digestion and absorption_Homo sapiens_hsa049740.48454810
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48204087
95Fanconi anemia pathway_Homo sapiens_hsa034600.47877596
96MAPK signaling pathway_Homo sapiens_hsa040100.46572720
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46367370
98Sulfur metabolism_Homo sapiens_hsa009200.45685399
99Renin-angiotensin system_Homo sapiens_hsa046140.45202023
100Oxytocin signaling pathway_Homo sapiens_hsa049210.44729795
101Calcium signaling pathway_Homo sapiens_hsa040200.44529365
102Endocytosis_Homo sapiens_hsa041440.44200891
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43910690
104Tight junction_Homo sapiens_hsa045300.43727630
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.43575774
106AMPK signaling pathway_Homo sapiens_hsa041520.42673843
107ABC transporters_Homo sapiens_hsa020100.41372305
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39166451
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38337844
110VEGF signaling pathway_Homo sapiens_hsa043700.38337034
111Alcoholism_Homo sapiens_hsa050340.38000972
112cAMP signaling pathway_Homo sapiens_hsa040240.35390198
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32993811
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32941784
115Metabolic pathways_Homo sapiens_hsa011000.32661148
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31272226
117Cocaine addiction_Homo sapiens_hsa050300.31031964
118Circadian entrainment_Homo sapiens_hsa047130.30216230
119RNA transport_Homo sapiens_hsa030130.29575895
120Viral carcinogenesis_Homo sapiens_hsa052030.28693012
121Circadian rhythm_Homo sapiens_hsa047100.27304216
122Cholinergic synapse_Homo sapiens_hsa047250.26881736
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26547857
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25996935
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24478284
126Pyrimidine metabolism_Homo sapiens_hsa002400.22764109
127ECM-receptor interaction_Homo sapiens_hsa045120.22560053
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20448320
129Inositol phosphate metabolism_Homo sapiens_hsa005620.19529960
130Taste transduction_Homo sapiens_hsa047420.16800076
131Glutamatergic synapse_Homo sapiens_hsa047240.16575563
132Salmonella infection_Homo sapiens_hsa051320.15086082
133HIF-1 signaling pathway_Homo sapiens_hsa040660.14243335
134B cell receptor signaling pathway_Homo sapiens_hsa046620.12011967
135Wnt signaling pathway_Homo sapiens_hsa043100.09737340
136Type II diabetes mellitus_Homo sapiens_hsa049300.08902075
137Basal cell carcinoma_Homo sapiens_hsa052170.08177442
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.07246834
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.04443082

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