SPEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)8.82970627
2axonemal dynein complex assembly (GO:0070286)7.52027807
3cilium movement (GO:0003341)7.18439084
4primary alcohol catabolic process (GO:0034310)7.16977167
5epithelial cilium movement (GO:0003351)6.62783510
6vitamin transmembrane transport (GO:0035461)6.34121911
7cilium or flagellum-dependent cell motility (GO:0001539)6.31057286
8ethanol metabolic process (GO:0006067)5.87786967
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.82245772
10protein localization to cilium (GO:0061512)5.68455076
11diterpenoid biosynthetic process (GO:0016102)5.49945892
12sensory perception of chemical stimulus (GO:0007606)5.46406458
13regulation of cilium movement (GO:0003352)5.33048494
14axoneme assembly (GO:0035082)5.29746393
15protein insertion into membrane (GO:0051205)5.20234155
16lung epithelium development (GO:0060428)5.17868713
17tolerance induction (GO:0002507)5.16567753
18centriole assembly (GO:0098534)5.12273671
19motile cilium assembly (GO:0044458)4.99716604
20sperm capacitation (GO:0048240)4.99667377
21negative regulation of T cell differentiation in thymus (GO:0033085)4.96695600
22pyrimidine-containing compound transmembrane transport (GO:0072531)4.78200266
23ventricular system development (GO:0021591)4.76242094
24establishment of apical/basal cell polarity (GO:0035089)4.74329237
25microtubule-based movement (GO:0007018)4.69134138
26negative regulation of immunoglobulin mediated immune response (GO:0002890)4.68294284
27negative regulation of B cell mediated immunity (GO:0002713)4.68294284
28response to xenobiotic stimulus (GO:0009410)4.58354217
29glomerular epithelial cell development (GO:0072310)4.48045255
30ethanol oxidation (GO:0006069)4.40474917
31negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.32303248
32intraciliary transport (GO:0042073)4.31567549
33cell projection assembly (GO:0030031)4.27735842
34regulation of interleukin-5 production (GO:0032674)4.25044743
35establishment or maintenance of monopolar cell polarity (GO:0061339)4.13569112
36establishment of monopolar cell polarity (GO:0061162)4.13569112
37microtubule depolymerization (GO:0007019)4.08883321
38regulation of chromatin binding (GO:0035561)4.07351917
39positive regulation of tolerance induction (GO:0002645)4.05175968
40negative regulation of humoral immune response (GO:0002921)3.98703341
41negative regulation of catenin import into nucleus (GO:0035414)3.97057403
42cytoplasmic microtubule organization (GO:0031122)3.91792483
43regulation of germinal center formation (GO:0002634)3.85245130
44regulation of interleukin-13 production (GO:0032656)3.78517201
45terpenoid biosynthetic process (GO:0016114)3.78121884
46retinoic acid metabolic process (GO:0042573)3.77027402
47microtubule polymerization or depolymerization (GO:0031109)3.76707731
48cilium morphogenesis (GO:0060271)3.72496930
49axonal fasciculation (GO:0007413)3.71261676
50dendritic spine morphogenesis (GO:0060997)3.70448988
51spinal cord development (GO:0021510)3.70298581
52acrosome assembly (GO:0001675)3.68086182
53protein polyglutamylation (GO:0018095)3.62978122
54limb bud formation (GO:0060174)3.58199270
55microtubule severing (GO:0051013)3.57789363
56sperm motility (GO:0030317)3.54640510
57GTP biosynthetic process (GO:0006183)3.51774108
58negative regulation of organelle assembly (GO:1902116)3.43115773
59olfactory bulb development (GO:0021772)3.39434246
60regulation of microtubule-based movement (GO:0060632)3.37546252
61facial nerve structural organization (GO:0021612)3.36359191
62exogenous drug catabolic process (GO:0042738)3.35943626
63establishment of tissue polarity (GO:0007164)3.29009090
64establishment of planar polarity (GO:0001736)3.29009090
65cerebral cortex neuron differentiation (GO:0021895)3.26960916
66fusion of sperm to egg plasma membrane (GO:0007342)3.26778667
67cranial nerve morphogenesis (GO:0021602)3.21156914
68hair cell differentiation (GO:0035315)3.21133056
69neuron recognition (GO:0008038)3.20813061
70cranial nerve structural organization (GO:0021604)3.20311390
71left/right axis specification (GO:0070986)3.17574191
72acrosome reaction (GO:0007340)3.14519484
73forebrain neuron differentiation (GO:0021879)3.13435998
74microtubule bundle formation (GO:0001578)3.13230317
75photoreceptor cell maintenance (GO:0045494)3.10705366
76primary alcohol metabolic process (GO:0034308)3.06373460
77cell wall macromolecule catabolic process (GO:0016998)3.06330174
78cell wall macromolecule metabolic process (GO:0044036)3.06330174
79lateral ventricle development (GO:0021670)3.06310638
80aldehyde catabolic process (GO:0046185)3.05272153
81calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.05175495
82nucleoside diphosphate phosphorylation (GO:0006165)3.04056249
83glutathione derivative biosynthetic process (GO:1901687)3.02934974
84glutathione derivative metabolic process (GO:1901685)3.02934974
85positive regulation of smoothened signaling pathway (GO:0045880)3.01925144
86retinol metabolic process (GO:0042572)3.01424562
87central nervous system projection neuron axonogenesis (GO:0021952)2.99439252
88cilium organization (GO:0044782)2.93047234
89forebrain neuron development (GO:0021884)2.92489713
90neuron cell-cell adhesion (GO:0007158)2.92202675
91regulation of tolerance induction (GO:0002643)2.91422920
92hydrogen peroxide biosynthetic process (GO:0050665)2.91271269
93regulation of female gonad development (GO:2000194)2.90738021
94UTP biosynthetic process (GO:0006228)2.90675960
95cilium assembly (GO:0042384)2.89512353
96layer formation in cerebral cortex (GO:0021819)2.89115703
97regulation of microtubule depolymerization (GO:0031114)2.88932987
98multicellular organismal water homeostasis (GO:0050891)2.84351177
99left/right pattern formation (GO:0060972)2.83986117
100spermatid nucleus differentiation (GO:0007289)2.83623252
101O-glycan processing (GO:0016266)2.82744676
102sperm-egg recognition (GO:0035036)2.81992132
103determination of left/right symmetry (GO:0007368)2.79625129
104microtubule-based process (GO:0007017)2.76731422
105smoothened signaling pathway (GO:0007224)2.75018717
106cell migration in hindbrain (GO:0021535)2.74746086
107spermatid development (GO:0007286)2.74279586
108negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73051216
109regulation of autophagic vacuole assembly (GO:2000785)2.72449003
110UTP metabolic process (GO:0046051)2.72192067
111negative regulation of axon extension involved in axon guidance (GO:0048843)2.71561109
112positive regulation of gastrulation (GO:2000543)2.70695284
113carnitine metabolic process (GO:0009437)2.70555060
114excretion (GO:0007588)2.69945651
115cellular component assembly involved in morphogenesis (GO:0010927)2.69594950
116single fertilization (GO:0007338)2.69294016
117multicellular organism reproduction (GO:0032504)2.68869048
118determination of bilateral symmetry (GO:0009855)2.68158296
119atrial cardiac muscle cell action potential (GO:0086014)2.68123008
120regulation of mesenchymal cell apoptotic process (GO:2001053)2.65734512
121semaphorin-plexin signaling pathway (GO:0071526)2.64225616
122binding of sperm to zona pellucida (GO:0007339)2.64095499
123phosphorelay signal transduction system (GO:0000160)2.63570151
124phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.63314613
125regulation of inclusion body assembly (GO:0090083)2.62967619
126negative regulation of inclusion body assembly (GO:0090084)2.62439587
127specification of symmetry (GO:0009799)2.62414712
128phosphatidylcholine biosynthetic process (GO:0006656)2.61978645
129axon extension (GO:0048675)2.60282574
130lateral sprouting from an epithelium (GO:0060601)2.59483921
131endocardial cushion morphogenesis (GO:0003203)2.59046047
132neuronal ion channel clustering (GO:0045161)2.58624640
133organelle assembly (GO:0070925)2.58359077
134drug catabolic process (GO:0042737)2.58252474
135cell proliferation in forebrain (GO:0021846)2.57825744
136centriole replication (GO:0007099)2.57749306
137apical protein localization (GO:0045176)2.57397769
138membrane repolarization during action potential (GO:0086011)2.56974677
139antibacterial humoral response (GO:0019731)2.56891612
140plasma membrane fusion (GO:0045026)2.56451982
141regulation of axon extension involved in axon guidance (GO:0048841)2.56114258
142reactive oxygen species biosynthetic process (GO:1903409)2.55826179
143ear development (GO:0043583)2.55305485
144renal system development (GO:0072001)2.54953777
145central nervous system neuron axonogenesis (GO:0021955)2.54589859
146negative regulation of axon guidance (GO:1902668)2.53841851
147pyrimidine nucleobase catabolic process (GO:0006208)2.53596574
148kidney mesenchyme development (GO:0072074)2.53481726
149oligosaccharide biosynthetic process (GO:0009312)2.53469056
150membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.53295795
151regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.52584804
152retinal ganglion cell axon guidance (GO:0031290)2.49427229
153ganglion development (GO:0061548)2.48643340
154one-carbon compound transport (GO:0019755)2.48052970
155regulation of axon guidance (GO:1902667)2.46466132
156guanosine-containing compound biosynthetic process (GO:1901070)2.45810562
157respiratory tube development (GO:0030323)2.45756821
158hippocampus development (GO:0021766)2.45458565
159antimicrobial humoral response (GO:0019730)2.44413125
160regulation of response to osmotic stress (GO:0047484)2.43633870
161lymph vessel development (GO:0001945)2.43419795
162negative regulation of microtubule polymerization (GO:0031115)2.43406017
163erythrocyte maturation (GO:0043249)2.43382315
164negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.43293237
165UV protection (GO:0009650)2.42331581
166hydrogen peroxide catabolic process (GO:0042744)2.42022379
167heart looping (GO:0001947)2.41807308
168progesterone metabolic process (GO:0042448)2.40636413
169cell-cell recognition (GO:0009988)2.39849507
170axon extension involved in axon guidance (GO:0048846)2.39706034
171neuron projection extension involved in neuron projection guidance (GO:1902284)2.39706034
172nonmotile primary cilium assembly (GO:0035058)2.38998837
173water homeostasis (GO:0030104)2.38164473
174negative regulation of microtubule depolymerization (GO:0007026)2.38093756
175nucleotide phosphorylation (GO:0046939)2.37359541
176embryonic camera-type eye development (GO:0031076)2.34453945
177CDP-diacylglycerol biosynthetic process (GO:0016024)2.33303496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.73478333
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.04243646
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88342805
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.79021921
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.78785008
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70049244
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.56495689
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.54013220
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50455106
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50455106
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47198111
12* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39664229
13* EZH2_27294783_Chip-Seq_ESCs_Mouse2.34365683
14RNF2_27304074_Chip-Seq_ESCs_Mouse2.30561991
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26821378
16SMC4_20622854_ChIP-Seq_HELA_Human2.25242769
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.24170475
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17428354
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15578735
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14669148
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12959158
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.11903678
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09648832
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.06902385
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06022109
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05433770
27ESR1_20079471_ChIP-ChIP_T-47D_Human2.03765379
28DROSHA_22980978_ChIP-Seq_HELA_Human2.03351344
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01833253
30RUNX1_27514584_Chip-Seq_MCF-7_Human2.00747199
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.00368844
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98155034
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96497146
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93134020
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85959520
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.78704062
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78612290
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.78546680
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.74335668
40P68_20966046_ChIP-Seq_HELA_Human1.71943107
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.63616130
42* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63498145
43* TP63_22573176_ChIP-Seq_HFKS_Human1.63273454
44RNF2_27304074_Chip-Seq_NSC_Mouse1.63206061
45* ELF1_20517297_ChIP-Seq_JURKAT_Human1.61574544
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60441242
47SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.58708950
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.58688068
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55502345
50YY1_22570637_ChIP-Seq_MALME-3M_Human1.51731333
51REST_21632747_ChIP-Seq_MESCs_Mouse1.50995514
52KLF5_25053715_ChIP-Seq_YYC3_Human1.49338787
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47933620
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.46358583
55CTCF_20526341_ChIP-Seq_ESCs_Human1.45775166
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45453995
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.44897072
58RAD21_21589869_ChIP-Seq_MESCs_Mouse1.44744333
59P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44702891
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42691066
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42691066
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40717356
63CREB1_26743006_Chip-Seq_LNCaP_Human1.38962953
64PHF8_20622854_ChIP-Seq_HELA_Human1.37135668
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36422327
66* RACK7_27058665_Chip-Seq_MCF-7_Human1.33704455
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32565665
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31214878
69KDM2B_26808549_Chip-Seq_K562_Human1.30000194
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.29360847
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26485316
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25861232
73AHR_22903824_ChIP-Seq_MCF-7_Human1.24671720
74TP63_23658742_ChIP-Seq_EP156T_Human1.24494716
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21848324
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21123196
77SOX2_20726797_ChIP-Seq_SW620_Human1.21039295
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.20539865
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19844004
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19769834
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19748102
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18357641
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17718894
84E2F1_20622854_ChIP-Seq_HELA_Human1.17585923
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17547140
86ZNF263_19887448_ChIP-Seq_K562_Human1.16761146
87ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16727711
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15190515
89GBX2_23144817_ChIP-Seq_PC3_Human1.15097487
90BCOR_27268052_Chip-Seq_Bcells_Human1.14426967
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13830608
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13526266
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12853699
94CTCF_27219007_Chip-Seq_Bcells_Human1.12541044
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.11826262
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11056822
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09564290
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08838215
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08824148
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.07834504
101BCL6_27268052_Chip-Seq_Bcells_Human1.07501068
102GATA1_19941826_ChIP-Seq_K562_Human1.07151791
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05327278
104ISL1_27105846_Chip-Seq_CPCs_Mouse1.05260180
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04892407
106FOXA1_25552417_ChIP-Seq_VCAP_Human1.04450398
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03946867
108SOX2_21211035_ChIP-Seq_LN229_Human1.03474915
109RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01014921
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00720084
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99557721
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99397970
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98620888
114STAT1_20625510_ChIP-Seq_HELA_Human0.98590711
115WDR5_24793694_ChIP-Seq_LNCAP_Human0.97895857
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97730736
117CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97625798
118P300_27268052_Chip-Seq_Bcells_Human0.97257331
119REST_18959480_ChIP-ChIP_MESCs_Mouse0.96955787
120SMRT_27268052_Chip-Seq_Bcells_Human0.96317156
121* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96025076
122FLI1_21867929_ChIP-Seq_CD8_Mouse0.96003286
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95714699
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95437022
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95324288
126ZNF274_21170338_ChIP-Seq_K562_Hela0.95094766
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.94228959
128TP53_22127205_ChIP-Seq_IMR90_Human0.93617729
129* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93500976
130LXR_22292898_ChIP-Seq_THP-1_Human0.92535508
131ETV1_20927104_ChIP-Seq_GIST48_Human0.91246337
132P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.90899970
133VDR_22108803_ChIP-Seq_LS180_Human0.90287508
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90104998
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.89853459
136TP53_18474530_ChIP-ChIP_U2OS_Human0.89720909
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89567081
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.89559461
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89392965
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89372261
141KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89188526
142PHF8_20622853_ChIP-Seq_HELA_Human0.88264936
143RARB_27405468_Chip-Seq_BRAIN_Mouse0.88170595
144SA1_27219007_Chip-Seq_Bcells_Human0.88100811
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88022389
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.87424635
147ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87384374
148RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87194490
149TET1_21490601_ChIP-Seq_MESCs_Mouse0.87148826
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.86872336
151CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86189204
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.85692466
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85488289
154HNFA_21074721_ChIP-Seq_CACO-2_Human0.85474802
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85169945
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84075344
157PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83956157
158ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83542174
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82872451
160TP63_17297297_ChIP-ChIP_HaCaT_Human0.82461198
161EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81320435
162TAF15_26573619_Chip-Seq_HEK293_Human0.81250765
163LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80634314
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.79816832
165MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79339503
166PIAS1_25552417_ChIP-Seq_VCAP_Human0.76215869
167KDM2B_26808549_Chip-Seq_JURKAT_Human0.75965152
168WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75900007
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75785517
170KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.74859778
171SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74347284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction6.70828834
2MP0008875_abnormal_xenobiotic_pharmacok6.46371445
3MP0002132_abnormal_respiratory_system4.56120626
4MP0004043_abnormal_pH_regulation3.97154565
5MP0008789_abnormal_olfactory_epithelium3.78288346
6MP0009780_abnormal_chondrocyte_physiolo3.75748683
7MP0005499_abnormal_olfactory_system3.34031493
8MP0005394_taste/olfaction_phenotype3.34031493
9MP0002102_abnormal_ear_morphology3.33955145
10MP0000566_synostosis3.19897799
11MP0005410_abnormal_fertilization2.92695436
12MP0003878_abnormal_ear_physiology2.86868815
13MP0005377_hearing/vestibular/ear_phenot2.86868815
14MP0002653_abnormal_ependyma_morphology2.60598333
15MP0004019_abnormal_vitamin_homeostasis2.59857402
16MP0001485_abnormal_pinna_reflex2.53376858
17MP0000778_abnormal_nervous_system2.21446944
18MP0005083_abnormal_biliary_tract2.21129411
19MP0000049_abnormal_middle_ear2.10441457
20MP0002938_white_spotting2.08257479
21MP0002909_abnormal_adrenal_gland2.08227729
22MP0004742_abnormal_vestibular_system2.06778143
23MP0000013_abnormal_adipose_tissue1.99539127
24MP0000383_abnormal_hair_follicle1.95318683
25MP0002184_abnormal_innervation1.92209068
26MP0000678_abnormal_parathyroid_gland1.88407600
27MP0008004_abnormal_stomach_pH1.85502964
28MP0005623_abnormal_meninges_morphology1.83997557
29MP0005257_abnormal_intraocular_pressure1.82284646
30MP0002282_abnormal_trachea_morphology1.79133609
31MP0001765_abnormal_ion_homeostasis1.78199968
32MP0002249_abnormal_larynx_morphology1.76157075
33MP0003880_abnormal_central_pattern1.74701971
34MP0002168_other_aberrant_phenotype1.74514165
35MP0009379_abnormal_foot_pigmentation1.73922463
36MP0005645_abnormal_hypothalamus_physiol1.72630653
37MP0010678_abnormal_skin_adnexa1.69024248
38MP0006276_abnormal_autonomic_nervous1.61345042
39MP0002638_abnormal_pupillary_reflex1.59862179
40MP0000537_abnormal_urethra_morphology1.59587111
41MP0010030_abnormal_orbit_morphology1.58837666
42MP0003656_abnormal_erythrocyte_physiolo1.57173332
43MP0003136_yellow_coat_color1.54868885
44MP0004859_abnormal_synaptic_plasticity1.54693403
45MP0006292_abnormal_olfactory_placode1.53784974
46MP0005423_abnormal_somatic_nervous1.42782238
47MP0000003_abnormal_adipose_tissue1.42137451
48MP0002233_abnormal_nose_morphology1.41382302
49MP0002234_abnormal_pharynx_morphology1.36360848
50MP0009250_abnormal_appendicular_skeleto1.34647056
51MP0002557_abnormal_social/conspecific_i1.33772715
52MP0000751_myopathy1.33680560
53MP0002752_abnormal_somatic_nervous1.32532729
54MP0003938_abnormal_ear_development1.31816276
55MP0001879_abnormal_lymphatic_vessel1.31095519
56MP0003942_abnormal_urinary_system1.27462957
57MP0000026_abnormal_inner_ear1.26006808
58MP0001502_abnormal_circadian_rhythm1.25149739
59MP0000681_abnormal_thyroid_gland1.23956801
60MP0003861_abnormal_nervous_system1.21864627
61MP0000631_abnormal_neuroendocrine_gland1.20810894
62MP0002277_abnormal_respiratory_mucosa1.19377234
63MP0002751_abnormal_autonomic_nervous1.16974043
64MP0002882_abnormal_neuron_morphology1.16607907
65MP0005551_abnormal_eye_electrophysiolog1.16254279
66MP0003698_abnormal_male_reproductive1.15900810
67MP0002735_abnormal_chemical_nociception1.15501085
68MP0005165_increased_susceptibility_to1.15411364
69MP0010234_abnormal_vibrissa_follicle1.12091084
70MP0002152_abnormal_brain_morphology1.10377778
71MP0003385_abnormal_body_wall1.10002363
72MP0001486_abnormal_startle_reflex1.08619794
73MP0005636_abnormal_mineral_homeostasis1.08324486
74MP0003646_muscle_fatigue1.06164024
75MP0005395_other_phenotype1.01595936
76MP0000534_abnormal_ureter_morphology1.01298884
77MP0003119_abnormal_digestive_system1.01126446
78MP0001188_hyperpigmentation1.01016709
79MP0002734_abnormal_mechanical_nocicepti0.98013236
80MP0009046_muscle_twitch0.96314215
81MP0000613_abnormal_salivary_gland0.96052522
82MP0000467_abnormal_esophagus_morphology0.95343803
83MP0002063_abnormal_learning/memory/cond0.94692141
84MP0002876_abnormal_thyroid_physiology0.94616121
85MP0004133_heterotaxia0.94188752
86MP0004270_analgesia0.93752541
87MP0005389_reproductive_system_phenotype0.93220080
88MP0008995_early_reproductive_senescence0.93141887
89MP0000762_abnormal_tongue_morphology0.91859956
90MP0002932_abnormal_joint_morphology0.91031392
91MP0003635_abnormal_synaptic_transmissio0.90808968
92MP0001963_abnormal_hearing_physiology0.89258321
93MP0003937_abnormal_limbs/digits/tail_de0.89171792
94MP0002092_abnormal_eye_morphology0.89079945
95MP0005248_abnormal_Harderian_gland0.87114555
96MP0002116_abnormal_craniofacial_bone0.86863993
97MP0002177_abnormal_outer_ear0.86493360
98MP0005195_abnormal_posterior_eye0.85901881
99MP0006072_abnormal_retinal_apoptosis0.85787433
100MP0001968_abnormal_touch/_nociception0.85200199
101MP0003755_abnormal_palate_morphology0.83967822
102MP0002822_catalepsy0.83084700
103MP0000955_abnormal_spinal_cord0.82782088
104MP0002572_abnormal_emotion/affect_behav0.82375576
105MP0002210_abnormal_sex_determination0.82080890
106MP0003935_abnormal_craniofacial_develop0.82006761
107MP0001970_abnormal_pain_threshold0.80049835
108MP0009643_abnormal_urine_homeostasis0.79958460
109MP0002272_abnormal_nervous_system0.79871479
110MP0001293_anophthalmia0.78885420
111MP0003115_abnormal_respiratory_system0.78206981
112MP0001346_abnormal_lacrimal_gland0.78015495
113MP0001286_abnormal_eye_development0.77361416
114MP0003879_abnormal_hair_cell0.77119458
115MP0005365_abnormal_bile_salt0.77112845
116MP0002067_abnormal_sensory_capabilities0.76674874
117MP0001270_distended_abdomen0.76448254
118MP0002160_abnormal_reproductive_system0.76030440
119MP0003315_abnormal_perineum_morphology0.75520156
120MP0002081_perinatal_lethality0.75438109
121MP0004858_abnormal_nervous_system0.75403087
122MP0002928_abnormal_bile_duct0.74800280
123MP0002136_abnormal_kidney_physiology0.74117131
124MP0004264_abnormal_extraembryonic_tissu0.72562482
125MP0010155_abnormal_intestine_physiology0.72253731
126MP0005367_renal/urinary_system_phenotyp0.72133403
127MP0000516_abnormal_urinary_system0.72133403
128MP0005391_vision/eye_phenotype0.72120286
129MP0001929_abnormal_gametogenesis0.71946074
130MP0005409_darkened_coat_color0.71811062
131MP0004215_abnormal_myocardial_fiber0.71472942
132MP0005167_abnormal_blood-brain_barrier0.70886736
133MP0001664_abnormal_digestion0.70839744
134MP0003453_abnormal_keratinocyte_physiol0.69665657
135MP0000465_gastrointestinal_hemorrhage0.69041541
136MP0001299_abnormal_eye_distance/0.67744438
137MP0001849_ear_inflammation0.66022395
138MP0002098_abnormal_vibrissa_morphology0.65933650
139MP0005503_abnormal_tendon_morphology0.65861666
140MP0003075_altered_response_to0.64384420
141MP0005164_abnormal_response_to0.58929679
142MP0009745_abnormal_behavioral_response0.58528021
143MP0005646_abnormal_pituitary_gland0.57946393
144MP0002229_neurodegeneration0.54695214
145MP0005085_abnormal_gallbladder_physiolo0.53459551
146MP0005253_abnormal_eye_physiology0.53400382
147MP0005408_hypopigmentation0.52784928
148MP0001324_abnormal_eye_pigmentation0.52306390
149MP0004883_abnormal_blood_vessel0.51832132
150MP0002161_abnormal_fertility/fecundity0.50764122
151MP0008872_abnormal_physiological_respon0.49729404
152MP0005220_abnormal_exocrine_pancreas0.48130295
153MP0001756_abnormal_urination0.47757630
154MP0001944_abnormal_pancreas_morphology0.45269678
155MP0003866_abnormal_defecation0.45120798

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.95830324
2Abnormal respiratory motile cilium physiology (HP:0012261)7.99524072
3Abnormal ciliary motility (HP:0012262)7.11454590
4Abnormal respiratory epithelium morphology (HP:0012253)6.99485006
5Abnormal respiratory motile cilium morphology (HP:0005938)6.99485006
6Rhinitis (HP:0012384)6.79882188
7Absent/shortened dynein arms (HP:0200106)6.69392263
8Dynein arm defect of respiratory motile cilia (HP:0012255)6.69392263
9Chronic bronchitis (HP:0004469)5.33431061
10Bronchiectasis (HP:0002110)3.83606207
11Occipital encephalocele (HP:0002085)3.80019725
12Pancreatic fibrosis (HP:0100732)3.47186750
13Retinal dysplasia (HP:0007973)3.30221917
14Fragile nails (HP:0001808)3.15482184
15Nephronophthisis (HP:0000090)3.14204753
16Chronic otitis media (HP:0000389)2.94459779
17Nasal polyposis (HP:0100582)2.90995460
18Cystic liver disease (HP:0006706)2.87425173
19Limb dystonia (HP:0002451)2.80934180
20Hyperactive renin-angiotensin system (HP:0000841)2.78059199
21Pancreatic cysts (HP:0001737)2.73403960
22Abnormality of dentin (HP:0010299)2.70978757
23Germ cell neoplasia (HP:0100728)2.63421609
24Chronic sinusitis (HP:0011109)2.62808110
25Abnormality of the nasal mucosa (HP:0000433)2.60031276
26Bronchitis (HP:0012387)2.49551757
27Chronic hepatic failure (HP:0100626)2.49450108
28Postaxial foot polydactyly (HP:0001830)2.41376824
29Infertility (HP:0000789)2.40323233
30Abnormality of the renal medulla (HP:0100957)2.40004076
31Abnormal sex determination (HP:0012244)2.35435622
32Sex reversal (HP:0012245)2.35435622
33Atelectasis (HP:0100750)2.32516057
34Hepatoblastoma (HP:0002884)2.32162206
35Abnormality of midbrain morphology (HP:0002418)2.28479279
36Molar tooth sign on MRI (HP:0002419)2.28479279
37Megalencephaly (HP:0001355)2.26298473
38Stage 5 chronic kidney disease (HP:0003774)2.21827198
39Overgrowth (HP:0001548)2.21491783
40Subacute progressive viral hepatitis (HP:0006572)2.21351415
41Morphological abnormality of the middle ear (HP:0008609)2.20357880
42Bell-shaped thorax (HP:0001591)2.14110851
43Abnormality of macular pigmentation (HP:0008002)2.13031281
44Bony spicule pigmentary retinopathy (HP:0007737)2.10831744
45Abnormality of the dental root (HP:0006486)2.09341081
46Taurodontia (HP:0000679)2.09341081
47Abnormality of permanent molar morphology (HP:0011071)2.09341081
48Congenital hepatic fibrosis (HP:0002612)2.04251899
49Anencephaly (HP:0002323)2.04229833
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03921929
51Abnormality of the dental pulp (HP:0006479)2.03334608
52Poikiloderma (HP:0001029)2.02553878
53Recurrent sinusitis (HP:0011108)2.00637332
54Male infertility (HP:0003251)1.98055418
55Recurrent otitis media (HP:0000403)1.97948846
56Gait imbalance (HP:0002141)1.97786143
57Abnormality of molar (HP:0011077)1.97450449
58Abnormality of molar morphology (HP:0011070)1.97450449
59Hydroureter (HP:0000072)1.95809891
60Aplasia/Hypoplasia of the tongue (HP:0010295)1.93917251
61Anosmia (HP:0000458)1.92614418
62Tubulointerstitial nephritis (HP:0001970)1.89239975
63Ventricular fibrillation (HP:0001663)1.88195099
64Male pseudohermaphroditism (HP:0000037)1.87728230
65Medial flaring of the eyebrow (HP:0010747)1.87409825
66Agitation (HP:0000713)1.86620353
67Median cleft lip (HP:0000161)1.81404194
68Conjunctival hamartoma (HP:0100780)1.79435243
69Severe visual impairment (HP:0001141)1.78415279
70Prolonged QT interval (HP:0001657)1.77046736
71Concave nail (HP:0001598)1.76637297
72Renal salt wasting (HP:0000127)1.74803396
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74799183
74Sudden death (HP:0001699)1.74744879
75Abnormality of the metopic suture (HP:0005556)1.73402184
76Absent frontal sinuses (HP:0002688)1.72416221
77Hyperthyroidism (HP:0000836)1.69528201
78Scrotal hypoplasia (HP:0000046)1.69344456
79Cone-rod dystrophy (HP:0000548)1.68526356
80Postaxial hand polydactyly (HP:0001162)1.68482292
81Oculomotor apraxia (HP:0000657)1.67780352
82Aplasia/Hypoplasia of the lens (HP:0008063)1.65639065
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.65445457
84Asplenia (HP:0001746)1.65275546
85True hermaphroditism (HP:0010459)1.64933839
86Tubular atrophy (HP:0000092)1.63625448
87Decreased circulating renin level (HP:0003351)1.63450589
88Intellectual disability, moderate (HP:0002342)1.62657757
89Split foot (HP:0001839)1.61280919
90Congenital primary aphakia (HP:0007707)1.61271499
91Amblyopia (HP:0000646)1.60915979
92Exotropia (HP:0000577)1.60374572
93Nephropathy (HP:0000112)1.59637114
94Furrowed tongue (HP:0000221)1.59005648
95Recurrent bronchitis (HP:0002837)1.56763466
96Midline defect of the nose (HP:0004122)1.56034854
97Arnold-Chiari malformation (HP:0002308)1.54819641
98Hamartoma of the eye (HP:0010568)1.54818867
99Facial cleft (HP:0002006)1.53748305
100Nephroblastoma (Wilms tumor) (HP:0002667)1.53688923
101Abnormality of the diencephalon (HP:0010662)1.53552720
102Narrow nasal bridge (HP:0000446)1.53090061
103Nephrogenic diabetes insipidus (HP:0009806)1.52986456
104Anophthalmia (HP:0000528)1.51607782
105Hyperacusis (HP:0010780)1.51169517
106Xerostomia (HP:0000217)1.49108089
107Entropion (HP:0000621)1.49077837
108Vaginal atresia (HP:0000148)1.48934883
109Sclerocornea (HP:0000647)1.48404729
110Genital tract atresia (HP:0001827)1.46946827
111Retinitis pigmentosa (HP:0000510)1.46713612
112Decreased subcutaneous fat (HP:0001002)1.46536882
113Hyperkalemia (HP:0002153)1.45940059
114Bifid tongue (HP:0010297)1.43537961
115Embryonal renal neoplasm (HP:0011794)1.43516970
116Insidious onset (HP:0003587)1.42702592
117Termporal pattern (HP:0011008)1.42702592
118Dysphonia (HP:0001618)1.42659490
119Syncope (HP:0001279)1.40365689
120Polydipsia (HP:0001959)1.39885905
121Abnormal drinking behavior (HP:0030082)1.39885905
122Truncus arteriosus (HP:0001660)1.39664955
123Febrile seizures (HP:0002373)1.39318839
124Elfin facies (HP:0004428)1.38778560
125Hyperaldosteronism (HP:0000859)1.38397619
126Hand muscle atrophy (HP:0009130)1.34091913
127Preaxial hand polydactyly (HP:0001177)1.33595013
128Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.30605802
129Short nail (HP:0001799)1.29945388
130Short thorax (HP:0010306)1.28368205
131Fetal akinesia sequence (HP:0001989)1.27922733
132Abnormality of renin-angiotensin system (HP:0000847)1.27669242
133Bifid scrotum (HP:0000048)1.25774000
134Poor coordination (HP:0002370)1.23286385
135Decreased central vision (HP:0007663)1.23057247
136Abnormality of the distal phalanges of the toes (HP:0010182)1.22368400
137Stridor (HP:0010307)1.21717719
138Abnormality of chloride homeostasis (HP:0011422)1.19992911
139Short femoral neck (HP:0100864)1.17501423
140Glucose intolerance (HP:0000833)1.16911882
141Tubulointerstitial abnormality (HP:0001969)1.16743290
142Hypokalemic alkalosis (HP:0001949)1.14441459
143Obstructive sleep apnea (HP:0002870)1.13415824
144Spinal muscular atrophy (HP:0007269)1.12947513
145Aplasia of the musculature (HP:0100854)1.08972262
146Popliteal pterygium (HP:0009756)1.08217449
147Hyponatremia (HP:0002902)1.06002102
148Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.05369444
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.02993302
150Abnormality of the frontal sinuses (HP:0002687)1.01733471
151Broad distal phalanx of finger (HP:0009836)1.01703749
152Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.00757741
153Diaphragmatic weakness (HP:0009113)0.99926352
154Upper limb amyotrophy (HP:0009129)0.99732951
155Distal upper limb amyotrophy (HP:0007149)0.99732951
156Abnormal biliary tract physiology (HP:0012439)0.98927327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.88818232
2EPHA24.68383316
3MAPK154.10985964
4PHKG24.00727850
5PHKG14.00727850
6MARK13.38993818
7EPHB23.10583602
8ICK3.04337966
9IRAK22.80378255
10TRIB32.58604251
11LMTK22.33490080
12ERBB32.29080751
13MKNK22.05243496
14CASK2.05139832
15DYRK32.02106636
16NME12.01144374
17RIPK12.00691100
18SMG11.99737583
19MAPKAPK31.98278255
20NTRK21.84083415
21MAP2K21.76564914
22DAPK21.75206104
23DMPK1.68058649
24TLK11.66365257
25PAK31.63151027
26STK241.57260290
27INSRR1.53427785
28MAP3K31.51872088
29SIK21.46181429
30PRKD31.45053082
31DYRK1B1.43580962
32ILK1.40526209
33WNK41.39345669
34TTK1.36984561
35BCR1.34471685
36PTK2B1.28373079
37CSK1.27643055
38TESK11.27035292
39DYRK21.26494632
40NEK61.25015540
41EPHB11.22438836
42EPHA41.19804434
43PRKD21.18449517
44PDK31.15595892
45PDK41.15595892
46CAMK2B1.11970740
47RPS6KA21.10260114
48PNCK1.09272340
49DYRK1A1.09149280
50TGFBR21.09119808
51STK391.07608400
52LRRK21.03899322
53MAPK131.03042504
54HIPK21.02139491
55CAMKK11.00765648
56EPHA30.99949184
57STK160.98530448
58EEF2K0.95143264
59TAOK10.95006725
60PRKCI0.93959888
61CAMK2D0.92530058
62STK110.89930194
63ERBB20.89423089
64MAP3K100.86701668
65UHMK10.82381913
66CAMK1G0.81671502
67STK100.79575581
68MKNK10.78807656
69TYRO30.77969724
70KSR10.77897397
71MST1R0.76583343
72TBK10.76366756
73IRAK10.74407303
74STK380.74028430
75RIPK40.73621473
76FER0.70210326
77ROCK10.69802205
78MAP3K70.68771269
79TIE10.66756729
80PRKG20.66727567
81ROCK20.61355684
82TNIK0.60713641
83PRKCZ0.60682664
84GRK10.58908324
85CCNB10.58131757
86PDPK10.56258835
87MAP3K20.56255557
88MAP3K120.55572048
89MARK20.55156729
90PKN10.54461007
91PAK20.53050167
92CAMK2A0.52981764
93CDK50.52580192
94PRKCG0.52164295
95CAMK2G0.52071411
96NEK20.48835978
97PTK60.48608907
98BMPR1B0.48581722
99RPS6KA10.47339020
100TRPM70.46813752
101PDK20.46560286
102SRPK10.44203554
103PRKG10.44140269
104CSNK1A1L0.43854339
105DDR20.43558516
106NTRK10.43027631
107RPS6KC10.42397670
108RPS6KL10.42397670
109DAPK30.42309849
110PBK0.42240079
111MINK10.42052564
112PRKCD0.41360697
113NUAK10.38897187
114PRKCE0.38681473
115PRKD10.37884594
116MET0.36753246
117SGK10.35951817
118FES0.35481622
119BRAF0.34953288
120AKT20.34222299
121PRKCQ0.33692054
122ARAF0.33661000
123AURKA0.33633817
124CAMK40.33091454
125RPS6KA40.33026936
126PIM20.32581081
127GRK60.31779865
128MUSK0.30781336
129MAP3K40.29967662
130PRKAA10.29824456
131NTRK30.29691435
132CDK90.29504850
133MAPKAPK20.28211972
134ADRBK10.27927732
135GSK3A0.27207162
136PKN20.27035198
137PRKAA20.27015021
138LIMK10.25558907
139PRKCA0.23581202
140MAP2K40.22444027
141SRC0.21928661
142PAK10.20863566
143PRKACA0.20742290
144SGK2230.19636984
145SGK4940.19636984
146PTK20.19426791
147PDK10.18442921
148ABL20.18233325
149FYN0.17407470
150PLK10.17206803
151PAK40.16834458
152MAP3K110.15957846
153MAP2K70.15947364
154ABL10.14740944
155CDC42BPA0.14293355
156RET0.13819817
157PAK60.13772870
158CDK190.13699950
159BRSK20.13184060

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.54254296
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.43959172
3Phenylalanine metabolism_Homo sapiens_hsa003604.96096468
4Histidine metabolism_Homo sapiens_hsa003404.50699415
5Chemical carcinogenesis_Homo sapiens_hsa052044.26241269
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.00105961
7Tyrosine metabolism_Homo sapiens_hsa003503.82659626
8beta-Alanine metabolism_Homo sapiens_hsa004102.96077803
9Glutathione metabolism_Homo sapiens_hsa004802.56265275
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.27319620
11Phototransduction_Homo sapiens_hsa047442.20906287
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.07650745
13Retinol metabolism_Homo sapiens_hsa008302.02704609
14Taste transduction_Homo sapiens_hsa047421.98772535
15Axon guidance_Homo sapiens_hsa043601.97009980
16Caffeine metabolism_Homo sapiens_hsa002321.78535662
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74357066
18Sphingolipid metabolism_Homo sapiens_hsa006001.72273326
19Huntingtons disease_Homo sapiens_hsa050161.69385457
20Cardiac muscle contraction_Homo sapiens_hsa042601.67679894
21Circadian entrainment_Homo sapiens_hsa047131.64466860
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62816009
23Morphine addiction_Homo sapiens_hsa050321.59466322
24Basal cell carcinoma_Homo sapiens_hsa052171.56741297
25Gastric acid secretion_Homo sapiens_hsa049711.55591034
26Cholinergic synapse_Homo sapiens_hsa047251.52998541
27Insulin secretion_Homo sapiens_hsa049111.48282524
28Estrogen signaling pathway_Homo sapiens_hsa049151.46979800
29Melanogenesis_Homo sapiens_hsa049161.46175054
30Dopaminergic synapse_Homo sapiens_hsa047281.45811760
31Renin secretion_Homo sapiens_hsa049241.42366978
32Glutamatergic synapse_Homo sapiens_hsa047241.42116621
33Salivary secretion_Homo sapiens_hsa049701.41475316
34Linoleic acid metabolism_Homo sapiens_hsa005911.40842521
35Amphetamine addiction_Homo sapiens_hsa050311.36309936
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35673895
37Oxidative phosphorylation_Homo sapiens_hsa001901.34094386
38Alzheimers disease_Homo sapiens_hsa050101.29717790
39Hedgehog signaling pathway_Homo sapiens_hsa043401.29210099
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26707102
41cAMP signaling pathway_Homo sapiens_hsa040241.26439251
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25015864
43Parkinsons disease_Homo sapiens_hsa050121.23703108
44Fatty acid degradation_Homo sapiens_hsa000711.23052818
45Nicotine addiction_Homo sapiens_hsa050331.22275777
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19369473
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.17897583
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16568939
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14853349
50Wnt signaling pathway_Homo sapiens_hsa043101.12356084
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11459486
52Gap junction_Homo sapiens_hsa045401.11018777
53Alcoholism_Homo sapiens_hsa050341.09618619
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09036483
55ABC transporters_Homo sapiens_hsa020101.08133481
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07973485
57GABAergic synapse_Homo sapiens_hsa047271.07788165
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06799705
59Peroxisome_Homo sapiens_hsa041461.05580973
60Oxytocin signaling pathway_Homo sapiens_hsa049211.03680129
61Cocaine addiction_Homo sapiens_hsa050301.02550514
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02386679
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00243443
64Endometrial cancer_Homo sapiens_hsa052130.99749212
65Glucagon signaling pathway_Homo sapiens_hsa049220.99096413
66Ribosome_Homo sapiens_hsa030100.98033913
67Pancreatic secretion_Homo sapiens_hsa049720.97831317
68Long-term potentiation_Homo sapiens_hsa047200.96569416
69Glioma_Homo sapiens_hsa052140.95689214
70Calcium signaling pathway_Homo sapiens_hsa040200.95671876
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93487718
72GnRH signaling pathway_Homo sapiens_hsa049120.93342047
73VEGF signaling pathway_Homo sapiens_hsa043700.91988830
74Notch signaling pathway_Homo sapiens_hsa043300.83722492
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83395226
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82859893
77Serotonergic synapse_Homo sapiens_hsa047260.82209258
78Collecting duct acid secretion_Homo sapiens_hsa049660.81301831
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.81254767
80Renal cell carcinoma_Homo sapiens_hsa052110.80649504
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79421446
82Colorectal cancer_Homo sapiens_hsa052100.77703744
83Arachidonic acid metabolism_Homo sapiens_hsa005900.77697151
84Dorso-ventral axis formation_Homo sapiens_hsa043200.76164398
85Dilated cardiomyopathy_Homo sapiens_hsa054140.76088579
86Hippo signaling pathway_Homo sapiens_hsa043900.74157920
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71989299
88Rap1 signaling pathway_Homo sapiens_hsa040150.71344200
89Hepatitis C_Homo sapiens_hsa051600.70976075
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70276725
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69806548
92Tight junction_Homo sapiens_hsa045300.69574560
93Choline metabolism in cancer_Homo sapiens_hsa052310.69047558
94Protein digestion and absorption_Homo sapiens_hsa049740.68275294
95Thyroid hormone synthesis_Homo sapiens_hsa049180.67371277
96ErbB signaling pathway_Homo sapiens_hsa040120.66793685
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66505517
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.66143984
99Ras signaling pathway_Homo sapiens_hsa040140.65395837
100Arginine and proline metabolism_Homo sapiens_hsa003300.65101659
101Chronic myeloid leukemia_Homo sapiens_hsa052200.61719732
102Melanoma_Homo sapiens_hsa052180.61687380
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60994747
104Inositol phosphate metabolism_Homo sapiens_hsa005620.60941596
105Insulin signaling pathway_Homo sapiens_hsa049100.60802110
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60525613
107Basal transcription factors_Homo sapiens_hsa030220.59951318
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59277916
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58223932
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.57712190
111Fatty acid biosynthesis_Homo sapiens_hsa000610.56361236
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55759213
113Type II diabetes mellitus_Homo sapiens_hsa049300.55253812
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54767956
115Long-term depression_Homo sapiens_hsa047300.53801727
116Bladder cancer_Homo sapiens_hsa052190.53441869
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.52012584
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.51947576
119mRNA surveillance pathway_Homo sapiens_hsa030150.51524747
120Sulfur relay system_Homo sapiens_hsa041220.50588186
121Synaptic vesicle cycle_Homo sapiens_hsa047210.49836989
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49564824
123Starch and sucrose metabolism_Homo sapiens_hsa005000.49502484
124PPAR signaling pathway_Homo sapiens_hsa033200.49087391
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.48397279
126Mineral absorption_Homo sapiens_hsa049780.47282440
127Circadian rhythm_Homo sapiens_hsa047100.46758245
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.46410496
129Prostate cancer_Homo sapiens_hsa052150.45490128
130Pathways in cancer_Homo sapiens_hsa052000.45457901
131MicroRNAs in cancer_Homo sapiens_hsa052060.44017243
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42570659
133Adherens junction_Homo sapiens_hsa045200.41575630
134AMPK signaling pathway_Homo sapiens_hsa041520.40786767
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.38414493
136Vibrio cholerae infection_Homo sapiens_hsa051100.37230230
137Arginine biosynthesis_Homo sapiens_hsa002200.36493587
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.36287051
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34160246
140Lysosome_Homo sapiens_hsa041420.34011568
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33691226
142Metabolic pathways_Homo sapiens_hsa011000.32729273
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31259803
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29433065
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.25158775
146Fructose and mannose metabolism_Homo sapiens_hsa000510.24874772
147Endocytosis_Homo sapiens_hsa041440.24568894
148Pyruvate metabolism_Homo sapiens_hsa006200.23886574
149Amoebiasis_Homo sapiens_hsa051460.21213858
150Bile secretion_Homo sapiens_hsa049760.19507312
151Glycerolipid metabolism_Homo sapiens_hsa005610.17380461
152Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17242102
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17057651
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16738784
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12358282
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11341690

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