SPECC1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.97363237
2Golgi transport vesicle coating (GO:0048200)4.40929469
3COPI coating of Golgi vesicle (GO:0048205)4.40929469
4macroautophagy (GO:0016236)3.87364514
5cytoplasmic mRNA processing body assembly (GO:0033962)3.75069971
6hypotonic response (GO:0006971)3.65141207
7growth hormone receptor signaling pathway (GO:0060396)3.62347428
8nuclear pore complex assembly (GO:0051292)3.61591628
9positive regulation of histone deacetylation (GO:0031065)3.58098953
10paraxial mesoderm development (GO:0048339)3.52804127
11regulation of RNA export from nucleus (GO:0046831)3.38998323
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.33959717
13insulin-like growth factor receptor signaling pathway (GO:0048009)3.26393845
14cellular response to growth hormone stimulus (GO:0071378)3.13344115
15pattern specification involved in kidney development (GO:0061004)3.13169813
16peptidyl-lysine dimethylation (GO:0018027)3.05813791
17regulation of nucleobase-containing compound transport (GO:0032239)3.01841338
18nuclear pore organization (GO:0006999)2.99366207
19negative regulation of potassium ion transmembrane transport (GO:1901380)2.99121295
20antigen processing and presentation via MHC class Ib (GO:0002475)2.97072568
21cytoskeletal anchoring at plasma membrane (GO:0007016)2.96869001
22retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96854857
23apoptotic cell clearance (GO:0043277)2.96800117
24mitotic sister chromatid cohesion (GO:0007064)2.96543101
25activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.90882476
26NLS-bearing protein import into nucleus (GO:0006607)2.87531841
27regulation of p38MAPK cascade (GO:1900744)2.87311391
28histone H3-K4 trimethylation (GO:0080182)2.83683869
29establishment of nucleus localization (GO:0040023)2.82501835
30body morphogenesis (GO:0010171)2.81596627
31regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.78856173
32dorsal/ventral axis specification (GO:0009950)2.78800515
33glucocorticoid receptor signaling pathway (GO:0042921)2.75782562
34positive regulation of nuclease activity (GO:0032075)2.73744895
35positive regulation of p38MAPK cascade (GO:1900745)2.73437012
36vascular endothelial growth factor signaling pathway (GO:0038084)2.71159178
37convergent extension (GO:0060026)2.70199619
38ectodermal placode formation (GO:0060788)2.68722457
39establishment of protein localization to Golgi (GO:0072600)2.68386767
40retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64546648
41layer formation in cerebral cortex (GO:0021819)2.63892958
42camera-type eye morphogenesis (GO:0048593)2.62430570
43protein targeting to Golgi (GO:0000042)2.61317714
44plasma membrane repair (GO:0001778)2.60680071
45morphogenesis of an epithelial sheet (GO:0002011)2.59945878
46type B pancreatic cell development (GO:0003323)2.59654198
47negative regulation of catenin import into nucleus (GO:0035414)2.57570394
48stress fiber assembly (GO:0043149)2.55494657
49planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54588579
50dosage compensation (GO:0007549)2.54403310
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53898701
52RNA localization (GO:0006403)2.53092030
53cell adhesion mediated by integrin (GO:0033627)2.53005713
54regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.52420258
55adherens junction assembly (GO:0034333)2.51722451
56ganglion development (GO:0061548)2.51385720
57heterochromatin organization (GO:0070828)2.51144101
58cell migration involved in sprouting angiogenesis (GO:0002042)2.50776071
59regulation of nuclease activity (GO:0032069)2.49710753
60regulation of secondary heart field cardioblast proliferation (GO:0003266)2.47108954
61regulation of cardioblast proliferation (GO:0003264)2.47108954
62corticosteroid receptor signaling pathway (GO:0031958)2.45596112
63heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.44844951
64coronary vasculature morphogenesis (GO:0060977)2.43685710
65embryonic foregut morphogenesis (GO:0048617)2.43449782
66peptidyl-threonine modification (GO:0018210)2.43371756
67negative regulation of fatty acid transport (GO:2000192)2.42840300
68negative regulation of DNA repair (GO:0045738)2.41366236
69axon extension involved in axon guidance (GO:0048846)2.40822957
70neuron projection extension involved in neuron projection guidance (GO:1902284)2.40822957
71semaphorin-plexin signaling pathway (GO:0071526)2.40071581
72glandular epithelial cell development (GO:0002068)2.40025137
73histone H3-K9 demethylation (GO:0033169)2.39397370
74axon extension (GO:0048675)2.39373598
75gastrulation with mouth forming second (GO:0001702)2.38995434
76embryonic viscerocranium morphogenesis (GO:0048703)2.38430961
77endoplasmic reticulum unfolded protein response (GO:0030968)2.38319011
78ear development (GO:0043583)2.36541738
79pore complex assembly (GO:0046931)2.36094604
80epithelial cell-cell adhesion (GO:0090136)2.35942215
81regulation of NFAT protein import into nucleus (GO:0051532)2.35178984
82regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35026664
83peptidyl-threonine phosphorylation (GO:0018107)2.34994002
84positive regulation of glycogen biosynthetic process (GO:0045725)2.34687467
85embryonic body morphogenesis (GO:0010172)2.34459803
86morphogenesis of an endothelium (GO:0003159)2.34213356
87endothelial tube morphogenesis (GO:0061154)2.34213356
88notochord development (GO:0030903)2.33530130
89mitotic chromosome condensation (GO:0007076)2.33476166
90establishment of apical/basal cell polarity (GO:0035089)2.33323140
91establishment of spindle orientation (GO:0051294)2.33195619
92embryonic camera-type eye development (GO:0031076)2.32391781
93focal adhesion assembly (GO:0048041)2.32141973
94cell-substrate adherens junction assembly (GO:0007045)2.32141973
95hippo signaling (GO:0035329)2.31474878
96negative regulation of chondrocyte differentiation (GO:0032331)2.31313400
97regulation of protein polyubiquitination (GO:1902914)2.30006008
98glial cell proliferation (GO:0014009)2.29651401
99cell-substrate junction assembly (GO:0007044)2.29459368
100collagen fibril organization (GO:0030199)2.29124231
101branching involved in mammary gland duct morphogenesis (GO:0060444)2.28939244
102sister chromatid segregation (GO:0000819)2.28866426
103positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.28712529
104fibroblast migration (GO:0010761)2.28615356
105vesicle coating (GO:0006901)2.28457805
106platelet-derived growth factor receptor signaling pathway (GO:0048008)2.28048921
107mammary gland epithelial cell proliferation (GO:0033598)2.27993986
108columnar/cuboidal epithelial cell development (GO:0002066)2.27501418
109establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.27486273
110heart valve formation (GO:0003188)2.27467878
111positive regulation of hormone biosynthetic process (GO:0046886)2.26363643
112establishment of monopolar cell polarity (GO:0061162)2.26278926
113establishment or maintenance of monopolar cell polarity (GO:0061339)2.26278926
114cellular response to unfolded protein (GO:0034620)2.26168894
115ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.26143245
116neuron projection extension (GO:1990138)2.25843946
117histone H3-K36 demethylation (GO:0070544)2.25282332
118cochlea morphogenesis (GO:0090103)2.25269537
119ER-nucleus signaling pathway (GO:0006984)2.24745023
120regulation of transforming growth factor beta2 production (GO:0032909)2.24264121
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.24105943
122DNA duplex unwinding (GO:0032508)2.23340413
123negative regulation of vascular permeability (GO:0043116)2.23205764
124mannose metabolic process (GO:0006013)2.22942575
125protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.22775810
126positive regulation of protein deacetylation (GO:0090312)2.21267175
127neural tube development (GO:0021915)2.21220620
128positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.20483732
129negative regulation of cell size (GO:0045792)2.20310676
130mitotic cytokinesis (GO:0000281)2.20257914
131eye morphogenesis (GO:0048592)2.19729401
132stress granule assembly (GO:0034063)2.19312872
133mitotic sister chromatid segregation (GO:0000070)2.19248060
134receptor catabolic process (GO:0032801)2.18900527
135cell volume homeostasis (GO:0006884)2.18258245
136embryonic retina morphogenesis in camera-type eye (GO:0060059)2.17934514
137regulation of establishment of planar polarity (GO:0090175)2.17909864
138aorta morphogenesis (GO:0035909)2.17885505
139cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.17651210
140COPII vesicle coating (GO:0048208)2.17516864
141nucleosome disassembly (GO:0006337)2.17036682
142protein-DNA complex disassembly (GO:0032986)2.17036682
143atrioventricular valve morphogenesis (GO:0003181)2.17010967
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.16681662
145exocrine pancreas development (GO:0031017)2.14480726
146skin morphogenesis (GO:0043589)2.14172504
147DNA geometric change (GO:0032392)2.14027870
148regulation of axon extension involved in axon guidance (GO:0048841)2.14000480
149heart morphogenesis (GO:0003007)2.13104186
150signal complex assembly (GO:0007172)2.12623889
151histone lysine demethylation (GO:0070076)2.12254617
152germ cell migration (GO:0008354)2.12223831
153cellular response to topologically incorrect protein (GO:0035967)2.11825546
154basement membrane organization (GO:0071711)2.11569127
155developmental cell growth (GO:0048588)2.11103702
156receptor recycling (GO:0001881)2.10936370
157regulation of tight junction assembly (GO:2000810)2.10014296
158establishment or maintenance of apical/basal cell polarity (GO:0035088)2.09862651
159establishment or maintenance of bipolar cell polarity (GO:0061245)2.09862651
160nucleus localization (GO:0051647)2.07368273
161polarized epithelial cell differentiation (GO:0030859)2.06864963
162regulation of histone deacetylation (GO:0031063)2.06209835
163regulation of glucose import in response to insulin stimulus (GO:2001273)2.05986398
164epithelial cell differentiation involved in prostate gland development (GO:0060742)2.04812700
165intestinal epithelial cell development (GO:0060576)2.04774367
166barbed-end actin filament capping (GO:0051016)2.04755251
167protein localization to endosome (GO:0036010)2.04222760
168pre-miRNA processing (GO:0031054)2.03430044
169establishment of protein localization to vacuole (GO:0072666)2.03242899
170protein targeting to vacuole (GO:0006623)2.03242899
171protein targeting to lysosome (GO:0006622)2.03242899
172cellular response to vitamin D (GO:0071305)2.02969935
173embryonic camera-type eye morphogenesis (GO:0048596)2.02744198
174regulation of interleukin-12 biosynthetic process (GO:0045075)2.02190280
175dopaminergic neuron differentiation (GO:0071542)2.01193259
176negative regulation of histone methylation (GO:0031061)2.00986279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.73963990
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.03974507
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78546206
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.49178393
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.28806538
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.70090210
7CLOCK_20551151_ChIP-Seq_293T_Human2.44012158
8AR_21909140_ChIP-Seq_LNCAP_Human2.33846819
9GATA1_22025678_ChIP-Seq_K562_Human2.20959123
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18143780
11* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.01351435
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.98482220
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96990034
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.96358225
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.95670155
16TCF7_22412390_ChIP-Seq_EML_Mouse1.92512313
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90399650
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88963058
19KDM2B_26808549_Chip-Seq_DND41_Human1.88217235
20MYC_22102868_ChIP-Seq_BL_Human1.79353112
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75968074
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.75006107
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73779502
24KDM2B_26808549_Chip-Seq_K562_Human1.71403733
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71262205
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67534153
27FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.66611748
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66451902
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64823037
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.60895881
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57712390
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.57416364
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.56692709
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.54625145
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.54259096
36ZNF263_19887448_ChIP-Seq_K562_Human1.53742104
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.52769004
38* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.51027757
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50834844
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50371971
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49901953
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.49486646
43NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49047456
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48913051
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48344602
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48170391
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47681535
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46540521
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43798406
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.42169113
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.42169113
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42049780
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.41548973
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.40891647
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.40333351
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39957327
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.39718959
58* BRD4_25478319_ChIP-Seq_HGPS_Human1.38590531
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.38176331
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36359365
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33373176
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.32568838
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.31766048
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.31699770
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.31606284
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30725644
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.30597872
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29698536
69CHD1_26751641_Chip-Seq_LNCaP_Human1.29616123
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.29137670
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26407579
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26076655
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25867906
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24569499
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24486849
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24117305
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23727766
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23358376
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22292734
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22126572
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21856941
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20453437
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20202264
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18995028
85SPI1_23127762_ChIP-Seq_K562_Human1.18558867
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18394563
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17751303
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17452058
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.16030447
90* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15696010
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15102003
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15102003
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14356955
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14281994
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.13816984
96TP53_22127205_ChIP-Seq_IMR90_Human1.12797475
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.12519924
98DROSHA_22980978_ChIP-Seq_HELA_Human1.12107970
99CJUN_26792858_Chip-Seq_BT549_Human1.11499295
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11094876
101CREB1_26743006_Chip-Seq_LNCaP_Human1.10217034
102AHR_22903824_ChIP-Seq_MCF-7_Human1.09171601
103GATA6_25053715_ChIP-Seq_YYC3_Human1.08108439
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07715595
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06553907
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06406929
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06152436
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04513494
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04513494
110* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03387328
111NCOR1_26117541_ChIP-Seq_K562_Human1.02810696
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02489763
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01706412
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01656730
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01386552
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01369833
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.01167598
118TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00416532
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.99499285
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99337942
121NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99085093
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.99074176
123UTX_26944678_Chip-Seq_JUKART_Human0.98475423
124TP53_16413492_ChIP-PET_HCT116_Human0.98111128
125RACK7_27058665_Chip-Seq_MCF-7_Human0.97966509
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97950637
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97149313
128VDR_21846776_ChIP-Seq_THP-1_Human0.97145242
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97077741
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95682306
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.95375199
132ATF3_27146783_Chip-Seq_COLON_Human0.95294533
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95279787
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95063210
135LXR_22292898_ChIP-Seq_THP-1_Human0.95026565
136RARB_27405468_Chip-Seq_BRAIN_Mouse0.95000744
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94458079
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94192853
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94134529
140GATA1_19941826_ChIP-Seq_K562_Human0.93187539
141AR_19668381_ChIP-Seq_PC3_Human0.92171506
142RUNX_20019798_ChIP-Seq_JUKART_Human0.91959401
143VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91490521
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91129672
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.90881598
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90463310
147KLF5_25053715_ChIP-Seq_YYC3_Human0.90402509
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89123910
149SOX3_22085726_ChIP-Seq_NPCs_Mouse0.88978156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.93479383
2MP0005076_abnormal_cell_differentiation2.97754228
3MP0002877_abnormal_melanocyte_morpholog2.95692296
4MP0003705_abnormal_hypodermis_morpholog2.83350280
5MP0003300_gastrointestinal_ulcer2.77400749
6MP0003283_abnormal_digestive_organ2.72522148
7MP0010352_gastrointestinal_tract_polyps2.71850471
8MP0008961_abnormal_basal_metabolism2.60441526
9MP0008057_abnormal_DNA_replication2.59662874
10MP0008438_abnormal_cutaneous_collagen2.45940003
11MP0003123_paternal_imprinting2.31691516
12MP0010234_abnormal_vibrissa_follicle2.28471664
13MP0005409_darkened_coat_color2.28032606
14MP0001849_ear_inflammation2.24284571
15MP0000537_abnormal_urethra_morphology2.16725606
16MP0003566_abnormal_cell_adhesion2.10473788
17MP0006054_spinal_hemorrhage2.09355741
18MP0002009_preneoplasia2.07565027
19MP0000733_abnormal_muscle_development1.94458583
20MP0002234_abnormal_pharynx_morphology1.86611340
21MP0003045_fibrosis1.78529360
22MP0003091_abnormal_cell_migration1.73721174
23MP0009780_abnormal_chondrocyte_physiolo1.72159864
24MP0005275_abnormal_skin_tensile1.69772430
25MP0003122_maternal_imprinting1.62942175
26MP0003941_abnormal_skin_development1.60483605
27MP0004272_abnormal_basement_membrane1.60303255
28MP0003937_abnormal_limbs/digits/tail_de1.57631281
29MP0003115_abnormal_respiratory_system1.57601476
30MP0002909_abnormal_adrenal_gland1.55028287
31MP0000003_abnormal_adipose_tissue1.52672376
32MP0002249_abnormal_larynx_morphology1.52505126
33MP0000013_abnormal_adipose_tissue1.49234272
34MP0005257_abnormal_intraocular_pressure1.47459250
35MP0000678_abnormal_parathyroid_gland1.47292103
36MP0000751_myopathy1.41963712
37MP0001299_abnormal_eye_distance/1.41774815
38MP0001958_emphysema1.40410275
39MP0002896_abnormal_bone_mineralization1.39871394
40MP0004185_abnormal_adipocyte_glucose1.39601667
41MP0000534_abnormal_ureter_morphology1.39585067
42MP0000462_abnormal_digestive_system1.35903677
43MP0004084_abnormal_cardiac_muscle1.35579074
44MP0004264_abnormal_extraembryonic_tissu1.34830165
45MP0000778_abnormal_nervous_system1.33986496
46MP0009278_abnormal_bone_marrow1.33932039
47MP0000428_abnormal_craniofacial_morphol1.33550789
48MP0010368_abnormal_lymphatic_system1.29758785
49MP0001915_intracranial_hemorrhage1.29335858
50MP0000432_abnormal_head_morphology1.27626201
51MP0003279_aneurysm1.27297420
52MP0005503_abnormal_tendon_morphology1.25809876
53MP0004130_abnormal_muscle_cell1.20766751
54MP0005187_abnormal_penis_morphology1.20030223
55MP0003121_genomic_imprinting1.19860110
56MP0003172_abnormal_lysosome_physiology1.19792138
57MP0005375_adipose_tissue_phenotype1.19715385
58MP0003111_abnormal_nucleus_morphology1.18369003
59MP0002092_abnormal_eye_morphology1.18288752
60MP0003755_abnormal_palate_morphology1.18261572
61MP0003119_abnormal_digestive_system1.17389740
62MP0009672_abnormal_birth_weight1.16536815
63MP0005623_abnormal_meninges_morphology1.15478000
64MP0001730_embryonic_growth_arrest1.14858435
65MP0001879_abnormal_lymphatic_vessel1.14788373
66MP0009250_abnormal_appendicular_skeleto1.13352038
67MP0004510_myositis1.13198313
68MP0002697_abnormal_eye_size1.12398700
69MP0004087_abnormal_muscle_fiber1.11792712
70MP0003183_abnormal_peptide_metabolism1.11362663
71MP0005380_embryogenesis_phenotype1.11209413
72MP0001672_abnormal_embryogenesis/_devel1.11209413
73MP0005367_renal/urinary_system_phenotyp1.11164695
74MP0000516_abnormal_urinary_system1.11164695
75MP0004233_abnormal_muscle_weight1.10609760
76MP0002233_abnormal_nose_morphology1.08498295
77MP0002925_abnormal_cardiovascular_devel1.08019638
78MP0001944_abnormal_pancreas_morphology1.07936848
79MP0002108_abnormal_muscle_morphology1.06933658
80MP0010630_abnormal_cardiac_muscle1.06617432
81MP0003303_peritoneal_inflammation1.05701024
82MP0003861_abnormal_nervous_system1.04550413
83MP0000566_synostosis1.03926922
84MP0003385_abnormal_body_wall1.03254526
85MP0005508_abnormal_skeleton_morphology1.02344440
86MP0009384_cardiac_valve_regurgitation1.02050296
87MP0003935_abnormal_craniofacial_develop1.00989413
88MP0000767_abnormal_smooth_muscle0.99111491
89MP0005666_abnormal_adipose_tissue0.98012793
90MP0010094_abnormal_chromosome_stability0.97870472
91MP0005670_abnormal_white_adipose0.97486588
92MP0000350_abnormal_cell_proliferation0.96229626
93MP0001270_distended_abdomen0.96152146
94MP0003077_abnormal_cell_cycle0.94998175
95MP0002114_abnormal_axial_skeleton0.94367151
96MP0009053_abnormal_anal_canal0.93938248
97MP0005167_abnormal_blood-brain_barrier0.91977628
98MP0002168_other_aberrant_phenotype0.91806282
99MP0000371_diluted_coat_color0.91196132
100MP0003890_abnormal_embryonic-extraembry0.90955101
101MP0001661_extended_life_span0.90860503
102MP0005248_abnormal_Harderian_gland0.90822693
103MP0002081_perinatal_lethality0.88852373
104MP0003942_abnormal_urinary_system0.88054852
105MP0002080_prenatal_lethality0.88009564
106MP0002060_abnormal_skin_morphology0.87394289
107MP0004947_skin_inflammation0.87056638
108MP0004858_abnormal_nervous_system0.86709796
109MP0003950_abnormal_plasma_membrane0.86148416
110MP0005023_abnormal_wound_healing0.86020036
111MP0002693_abnormal_pancreas_physiology0.85959776
112MP0000266_abnormal_heart_morphology0.85656913
113MP0002822_catalepsy0.85441902
114MP0000955_abnormal_spinal_cord0.84521597
115MP0001286_abnormal_eye_development0.84379048
116MP0010030_abnormal_orbit_morphology0.83193405
117MP0002932_abnormal_joint_morphology0.82775240
118MP0008932_abnormal_embryonic_tissue0.82113002
119MP0001697_abnormal_embryo_size0.81670309
120MP0002084_abnormal_developmental_patter0.81120933
121MP0001175_abnormal_lung_morphology0.80788799
122MP0002089_abnormal_postnatal_growth/wei0.80774349
123MP0003868_abnormal_feces_composition0.77043650
124MP0004197_abnormal_fetal_growth/weight/0.75896376
125MP0002128_abnormal_blood_circulation0.75089917
126MP0004808_abnormal_hematopoietic_stem0.74026543
127MP0004036_abnormal_muscle_relaxation0.72323520
128MP0009703_decreased_birth_body0.72082974
129MP0002086_abnormal_extraembryonic_tissu0.71761911
130MP0005058_abnormal_lysosome_morphology0.70454313
131MP0000538_abnormal_urinary_bladder0.69817803
132MP0002088_abnormal_embryonic_growth/wei0.69397529
133MP0002928_abnormal_bile_duct0.69346792
134MP0002116_abnormal_craniofacial_bone0.68583806
135MP0008995_early_reproductive_senescence0.67794138
136MP0003984_embryonic_growth_retardation0.67589980
137MP0010307_abnormal_tumor_latency0.66659044
138MP0010678_abnormal_skin_adnexa0.65210257
139MP0002085_abnormal_embryonic_tissue0.65154901
140MP0002396_abnormal_hematopoietic_system0.64742798
141MP0003828_pulmonary_edema0.63731159

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.60643146
2Macroorchidism (HP:0000053)3.23876327
3Hyperacusis (HP:0010780)3.00110260
4Aortic aneurysm (HP:0004942)2.99351895
5Subacute progressive viral hepatitis (HP:0006572)2.99076183
6Neonatal short-limb short stature (HP:0008921)2.91817964
7Vertebral arch anomaly (HP:0008438)2.86273314
8Shallow orbits (HP:0000586)2.79242008
9Ankle contracture (HP:0006466)2.76236119
10Abnormality of the lower motor neuron (HP:0002366)2.76187633
11Hematochezia (HP:0002573)2.59934534
12Aneurysm (HP:0002617)2.58625472
13Protrusio acetabuli (HP:0003179)2.53675429
14Bowel diverticulosis (HP:0005222)2.49396859
15Overgrowth (HP:0001548)2.46882689
16Renal duplication (HP:0000075)2.39000444
17Cervical subluxation (HP:0003308)2.38903935
18Broad metatarsal (HP:0001783)2.37044198
19Mitral valve prolapse (HP:0001634)2.35801619
20Wrist flexion contracture (HP:0001239)2.33390070
21Aortic dissection (HP:0002647)2.30548536
22Mildly elevated creatine phosphokinase (HP:0008180)2.28412903
23Elfin facies (HP:0004428)2.28171736
24Dilatation of the ascending aorta (HP:0005111)2.26985720
25Bladder diverticulum (HP:0000015)2.23772398
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23721975
27Short 4th metacarpal (HP:0010044)2.23721975
28Long toe (HP:0010511)2.22921006
29Abnormality of the distal phalanx of the thumb (HP:0009617)2.21233737
30Lymphangioma (HP:0100764)2.20827254
31Papillary thyroid carcinoma (HP:0002895)2.20800854
32Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19736532
33Type 1 muscle fiber predominance (HP:0003803)2.18619050
34Relative macrocephaly (HP:0004482)2.18294838
35Micronodular cirrhosis (HP:0001413)2.17375980
36Renovascular hypertension (HP:0100817)2.15033122
37Hepatoblastoma (HP:0002884)2.14931921
38Abnormality of the calcaneus (HP:0008364)2.09577834
39Rectal prolapse (HP:0002035)2.08470193
40Missing ribs (HP:0000921)2.07230567
41Heterotopia (HP:0002282)2.06295051
42Scapular winging (HP:0003691)2.04622543
43Enlarged penis (HP:0000040)2.04530067
44Long eyelashes (HP:0000527)2.03476912
45Deep philtrum (HP:0002002)2.02509305
46Frequent falls (HP:0002359)2.01887663
47Abnormality of the phalanges of the hallux (HP:0010057)2.00995635
48Diastasis recti (HP:0001540)2.00628874
49Ulnar bowing (HP:0003031)1.99369751
50Increased connective tissue (HP:0009025)1.95870401
51Exostoses (HP:0100777)1.94753919
52Back pain (HP:0003418)1.93047393
53Broad distal phalanx of finger (HP:0009836)1.91884254
54Turricephaly (HP:0000262)1.91758237
55Germ cell neoplasia (HP:0100728)1.91705231
56Camptodactyly of toe (HP:0001836)1.90963604
57Thin bony cortex (HP:0002753)1.90638411
58Abnormality of the fingertips (HP:0001211)1.90573915
59Soft skin (HP:0000977)1.90521163
60Striae distensae (HP:0001065)1.89999240
61Broad phalanges of the hand (HP:0009768)1.87682170
62Flat cornea (HP:0007720)1.87660432
63Broad long bones (HP:0005622)1.87174101
64Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86860144
65Capillary hemangiomas (HP:0005306)1.86703307
66Bell-shaped thorax (HP:0001591)1.85666998
67Neoplasm of the heart (HP:0100544)1.84994870
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84737856
69Abnormality of dentin (HP:0010299)1.84464128
70Increased variability in muscle fiber diameter (HP:0003557)1.84068254
71Wormian bones (HP:0002645)1.83265244
72Broad thumb (HP:0011304)1.82259585
73Broad phalanx (HP:0006009)1.81929431
74Mitral regurgitation (HP:0001653)1.81887268
75Broad finger (HP:0001500)1.81520185
76Right ventricular cardiomyopathy (HP:0011663)1.80171633
77Spinal rigidity (HP:0003306)1.79763862
78Termporal pattern (HP:0011008)1.78537952
79Insidious onset (HP:0003587)1.78537952
80Menstrual irregularities (HP:0000858)1.78354437
81Obsessive-compulsive behavior (HP:0000722)1.78178663
82Failure to thrive in infancy (HP:0001531)1.77679304
83Arnold-Chiari malformation (HP:0002308)1.77300309
84Facial hemangioma (HP:0000329)1.77006632
85Long palpebral fissure (HP:0000637)1.76079704
86Atrophic scars (HP:0001075)1.74812015
87Flat acetabular roof (HP:0003180)1.74549968
88Chin dimple (HP:0010751)1.74387383
89Broad face (HP:0000283)1.74320523
90Genu recurvatum (HP:0002816)1.73974415
91Cubitus valgus (HP:0002967)1.73235314
92Precocious puberty (HP:0000826)1.72698857
93Narrow palate (HP:0000189)1.72404854
94Abnormality of the 4th metacarpal (HP:0010012)1.71421406
95Arterial tortuosity (HP:0005116)1.71236454
96Hyperextensible skin (HP:0000974)1.71108072
97Spinal cord lesions (HP:0100561)1.70757049
98Syringomyelia (HP:0003396)1.70757049
99Persistence of primary teeth (HP:0006335)1.70427873
100Metaphyseal cupping (HP:0003021)1.69770579
101Hypoplastic labia majora (HP:0000059)1.69672063
102Deviation of the hallux (HP:0010051)1.69068985
103Hallux valgus (HP:0001822)1.68698886
104Difficulty running (HP:0009046)1.67735815
105Joint laxity (HP:0001388)1.67493366
106Overriding aorta (HP:0002623)1.66747994
107Bronchomalacia (HP:0002780)1.65857306
108Abnormality of the ischium (HP:0003174)1.64782357
109Asymmetry of the thorax (HP:0001555)1.64099169
110Wide anterior fontanel (HP:0000260)1.64092167
111Hyperglycemia (HP:0003074)1.63649970
112Short metatarsal (HP:0010743)1.63509967
113Biconcave vertebral bodies (HP:0004586)1.63506142
114Calcaneovalgus deformity (HP:0001848)1.62712940
115Natal tooth (HP:0000695)1.62358621
116Midline defect of the nose (HP:0004122)1.62252365
117Malignant gastrointestinal tract tumors (HP:0006749)1.61929124
118Gastrointestinal carcinoma (HP:0002672)1.61929124
119Patellar dislocation (HP:0002999)1.61920218
120Coronal craniosynostosis (HP:0004440)1.61414612
121Insulin-resistant diabetes mellitus (HP:0000831)1.61080631
122Truncal obesity (HP:0001956)1.60133912
123Advanced eruption of teeth (HP:0006288)1.59594857
124Insomnia (HP:0100785)1.59559830
125Abnormality of skeletal muscle fiber size (HP:0012084)1.58596874
126Spondylolisthesis (HP:0003302)1.58259763
127Abnormality of the labia majora (HP:0012881)1.58252420
128Abnormality of the right ventricle (HP:0001707)1.57646286
129Dental malocclusion (HP:0000689)1.57498569
130Vascular tortuosity (HP:0004948)1.56987842
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.56352897
132Abnormality of polysaccharide metabolism (HP:0011012)1.56352897
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.56352897
134Hypoplastic ischia (HP:0003175)1.56185034
135Disproportionate tall stature (HP:0001519)1.56180065
136Cerebral inclusion bodies (HP:0100314)1.56156712
137Genu valgum (HP:0002857)1.55991054
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55678075
139Acute myeloid leukemia (HP:0004808)1.54728104
140Severe short stature (HP:0003510)1.54602365
141Small epiphyses (HP:0010585)1.54019598
142Asymmetric septal hypertrophy (HP:0001670)1.53574510
143Smooth philtrum (HP:0000319)1.53543373
144Broad palm (HP:0001169)1.53484497
145Sandal gap (HP:0001852)1.53254840
146Premature rupture of membranes (HP:0001788)1.52994926
147Limited elbow extension (HP:0001377)1.52967467
148Increased nuchal translucency (HP:0010880)1.52542753
149Short nail (HP:0001799)1.52342842
150Pointed chin (HP:0000307)1.52250502
151Flattened epiphyses (HP:0003071)1.52237043
152Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.51961476
153Hypoglycemic seizures (HP:0002173)1.51850173
154Abnormality of the aortic arch (HP:0012303)1.50917141
155Thin ribs (HP:0000883)1.50722691
156Laryngomalacia (HP:0001601)1.50491381
157Hyporeflexia of lower limbs (HP:0002600)1.50296919
158Hypoplastic toenails (HP:0001800)1.50270742
159Hemangiomatosis (HP:0007461)1.50250116
160Difficulty climbing stairs (HP:0003551)1.49728564
161Hyperinsulinemic hypoglycemia (HP:0000825)1.49551677
162Leiomyosarcoma (HP:0100243)1.49339670
163Uterine leiomyosarcoma (HP:0002891)1.49339670
164Knee flexion contracture (HP:0006380)1.49131447
165Subaortic stenosis (HP:0001682)1.48612742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.57797460
2STK38L3.48037728
3AKT33.42594477
4RIPK13.35989329
5PDGFRA2.98425005
6CDK122.40665908
7TTN2.38145555
8PKN22.34228702
9LATS12.30411821
10PNCK2.22863568
11EEF2K2.17070675
12SIK12.09754618
13PTK62.08445438
14MARK12.04584624
15CAMK1D1.91829908
16MAP3K101.87376382
17DDR21.83589485
18ERN11.81874173
19EPHA31.80954164
20PDGFRB1.68323879
21DMPK1.63680540
22FRK1.63621503
23FGFR41.61551043
24PRKD31.59691342
25FER1.56605411
26CAMK1G1.54995446
27FGFR31.51637462
28INSRR1.49364022
29RET1.48293170
30ICK1.44818512
31LMTK21.36664440
32TGFBR21.33571028
33CDC71.32064127
34TYRO31.31747778
35PASK1.31573676
36SCYL21.25900258
37HIPK21.23356679
38FGFR21.20496040
39EPHB21.18257172
40TAOK31.18082472
41PTK21.14541225
42SGK21.14118113
43MTOR1.13060545
44STK101.11284990
45CDC42BPA1.10876125
46TBK11.05612754
47JAK11.05454918
48SGK4941.04513791
49SGK2231.04513791
50MAP3K21.04411744
51CASK1.03192224
52LRRK21.02498386
53PAK30.97059388
54MET0.96573801
55SMG10.96449997
56BMX0.94826991
57EPHB10.92714046
58PRKCH0.92343944
59TNIK0.91699130
60FLT30.89443689
61STK30.88669686
62PAK20.88631513
63CHUK0.85365802
64STK390.84226853
65EPHA20.83792062
66SIK30.82115448
67JAK30.81665025
68ALK0.78796710
69SIK20.78690227
70BRAF0.78246961
71CDK80.77170615
72SGK30.76726383
73LATS20.76554327
74CDK60.76058829
75PAK40.74513928
76NEK90.72498257
77DYRK1B0.71571402
78CHEK10.70969019
79KSR10.69993219
80PRKD10.69644353
81KSR20.67887296
82ERBB30.65837602
83CDK70.65419693
84ERBB20.64079719
85CHEK20.64029109
86CDK90.63420414
87MAP3K70.60579220
88RPS6KA20.59853164
89CSF1R0.59669505
90STK40.59188701
91ROCK10.58603415
92PRKAA10.57431516
93JAK20.57401059
94CDK30.56593225
95ATM0.54965611
96CDK20.54395079
97PLK40.53248765
98MAPK100.53069257
99CSNK1E0.51548382
100AKT10.50545702
101GSK3B0.50382995
102RPS6KA40.49351207
103MAPK140.49230601
104NTRK10.48962722
105ERBB40.48733657
106MARK30.47898227
107CDK10.47582427
108MAP3K90.46771566
109FGFR10.46724723
110PRKD20.46553139
111CSNK1D0.46434850
112TIE10.44680528
113CDK40.44641224
114TTK0.43764573
115TGFBR10.43700047
116MARK20.43624037
117WNK10.42831402
118PRKDC0.42806461
119ATR0.42448735
120IKBKE0.42299129
121TRPM70.42179050
122STK380.40914775
123ITK0.40839345
124ROCK20.40683469
125TAOK10.40664568
126MATK0.40584259
127BCR0.39575086
128TSSK60.39540144
129BRSK20.37799621
130MAP2K20.37472959
131MAPK90.37277063
132MELK0.36928009
133MYLK0.36375629
134NEK20.35838771
135MAP2K10.35414365
136NUAK10.35178181
137AKT20.34921202
138INSR0.34871086
139EGFR0.34445262
140MAP3K10.33719189
141WNK40.33293263
142MAPK80.32464219
143BRD40.32427244
144MAPK10.32191548
145CAMKK10.31901815
146PRKAA20.31294300
147PAK60.30789972
148SRC0.30758225
149RPS6KB10.29962590
150MINK10.29798920
151YES10.29747209

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049501.82941185
2Adherens junction_Homo sapiens_hsa045201.76325020
3Type II diabetes mellitus_Homo sapiens_hsa049301.72053462
4Chronic myeloid leukemia_Homo sapiens_hsa052201.68833429
5Focal adhesion_Homo sapiens_hsa045101.58321853
6Insulin resistance_Homo sapiens_hsa049311.51210124
7Carbohydrate digestion and absorption_Homo sapiens_hsa049731.43366629
8Thyroid cancer_Homo sapiens_hsa052161.41877798
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41480109
10Proteoglycans in cancer_Homo sapiens_hsa052051.40967544
11Small cell lung cancer_Homo sapiens_hsa052221.35118278
12Endometrial cancer_Homo sapiens_hsa052131.33202109
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31340763
14mTOR signaling pathway_Homo sapiens_hsa041501.28889004
15Dorso-ventral axis formation_Homo sapiens_hsa043201.26670906
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26522937
17ECM-receptor interaction_Homo sapiens_hsa045121.25762238
18Pancreatic cancer_Homo sapiens_hsa052121.18197183
19Lysine degradation_Homo sapiens_hsa003101.17954079
20Cell cycle_Homo sapiens_hsa041101.17854174
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15835355
22MicroRNAs in cancer_Homo sapiens_hsa052061.15172040
23Prolactin signaling pathway_Homo sapiens_hsa049171.14895909
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.14257289
25Insulin secretion_Homo sapiens_hsa049111.14173927
26Estrogen signaling pathway_Homo sapiens_hsa049151.11914295
27Dilated cardiomyopathy_Homo sapiens_hsa054141.11339408
28Colorectal cancer_Homo sapiens_hsa052101.11016119
29Viral myocarditis_Homo sapiens_hsa054161.10437453
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08739851
31Amoebiasis_Homo sapiens_hsa051461.08303306
32Basal cell carcinoma_Homo sapiens_hsa052171.05307216
33Protein digestion and absorption_Homo sapiens_hsa049741.05037394
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04483797
35Hippo signaling pathway_Homo sapiens_hsa043901.04424653
36Toxoplasmosis_Homo sapiens_hsa051451.03863518
37DNA replication_Homo sapiens_hsa030301.02727219
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.00641428
39Vitamin B6 metabolism_Homo sapiens_hsa007500.99959617
40Renin-angiotensin system_Homo sapiens_hsa046140.99668583
41Insulin signaling pathway_Homo sapiens_hsa049100.99185722
42Notch signaling pathway_Homo sapiens_hsa043300.98476143
43mRNA surveillance pathway_Homo sapiens_hsa030150.97734501
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97700259
45TNF signaling pathway_Homo sapiens_hsa046680.97679718
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97525986
47Melanoma_Homo sapiens_hsa052180.97303784
48Fatty acid biosynthesis_Homo sapiens_hsa000610.95176720
49Platelet activation_Homo sapiens_hsa046110.94690254
50Gap junction_Homo sapiens_hsa045400.94185644
51Glioma_Homo sapiens_hsa052140.93857864
52Melanogenesis_Homo sapiens_hsa049160.93145553
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92886028
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92528898
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91545921
56Osteoclast differentiation_Homo sapiens_hsa043800.91141165
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90087351
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90051345
59VEGF signaling pathway_Homo sapiens_hsa043700.89968367
60Non-homologous end-joining_Homo sapiens_hsa034500.87572644
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87127946
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87034645
63Pathways in cancer_Homo sapiens_hsa052000.84251759
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.83556474
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.82878628
66B cell receptor signaling pathway_Homo sapiens_hsa046620.82566951
67Acute myeloid leukemia_Homo sapiens_hsa052210.82331840
68Prostate cancer_Homo sapiens_hsa052150.82323572
69Glucagon signaling pathway_Homo sapiens_hsa049220.81448363
70Circadian rhythm_Homo sapiens_hsa047100.81019120
71Tight junction_Homo sapiens_hsa045300.80527428
72Renal cell carcinoma_Homo sapiens_hsa052110.79880404
73AMPK signaling pathway_Homo sapiens_hsa041520.79184830
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78637352
75Non-small cell lung cancer_Homo sapiens_hsa052230.78492789
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78437552
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78432859
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77703143
79Bladder cancer_Homo sapiens_hsa052190.76945700
80Hepatitis B_Homo sapiens_hsa051610.76859512
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76489882
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76279309
83Rap1 signaling pathway_Homo sapiens_hsa040150.76184287
84Wnt signaling pathway_Homo sapiens_hsa043100.76060803
85FoxO signaling pathway_Homo sapiens_hsa040680.75575672
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75096592
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75074440
88ErbB signaling pathway_Homo sapiens_hsa040120.73901719
89Oocyte meiosis_Homo sapiens_hsa041140.73512005
90HTLV-I infection_Homo sapiens_hsa051660.73015177
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.71671087
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.71338617
93TGF-beta signaling pathway_Homo sapiens_hsa043500.70872839
94Axon guidance_Homo sapiens_hsa043600.70227641
95Endocytosis_Homo sapiens_hsa041440.70083943
96Renin secretion_Homo sapiens_hsa049240.69633195
97Inositol phosphate metabolism_Homo sapiens_hsa005620.69419730
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67919410
99Hedgehog signaling pathway_Homo sapiens_hsa043400.67662363
100Viral carcinogenesis_Homo sapiens_hsa052030.67640696
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67456496
102Choline metabolism in cancer_Homo sapiens_hsa052310.67186990
103Thyroid hormone synthesis_Homo sapiens_hsa049180.66879529
104GnRH signaling pathway_Homo sapiens_hsa049120.66040794
105N-Glycan biosynthesis_Homo sapiens_hsa005100.66021124
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65575005
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65423436
108Cocaine addiction_Homo sapiens_hsa050300.65381309
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65099405
110Fat digestion and absorption_Homo sapiens_hsa049750.64992300
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64975078
112Apoptosis_Homo sapiens_hsa042100.64685706
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64595766
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64562131
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64069548
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63836714
117Long-term potentiation_Homo sapiens_hsa047200.63628463
118RNA transport_Homo sapiens_hsa030130.62419405
119Prion diseases_Homo sapiens_hsa050200.60085719
120Ras signaling pathway_Homo sapiens_hsa040140.54290865
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49763378
122Cholinergic synapse_Homo sapiens_hsa047250.48751924
123Oxytocin signaling pathway_Homo sapiens_hsa049210.46270883
124Fatty acid metabolism_Homo sapiens_hsa012120.43034309
125MAPK signaling pathway_Homo sapiens_hsa040100.41384825

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