SPDYE8P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)4.95098129
2piRNA metabolic process (GO:0034587)4.78531921
3ether lipid metabolic process (GO:0046485)4.24093454
4opioid receptor signaling pathway (GO:0038003)4.15961899
5regulation of cilium movement (GO:0003352)4.02730589
6behavioral response to ethanol (GO:0048149)3.96093301
7ubiquinone biosynthetic process (GO:0006744)3.92732686
8epithelial cilium movement (GO:0003351)3.90292911
9tryptophan catabolic process (GO:0006569)3.84166783
10indole-containing compound catabolic process (GO:0042436)3.84166783
11indolalkylamine catabolic process (GO:0046218)3.84166783
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73235974
13response to pheromone (GO:0019236)3.73171574
14mannosylation (GO:0097502)3.71216649
15platelet dense granule organization (GO:0060155)3.70010968
16indolalkylamine metabolic process (GO:0006586)3.65253526
17intraciliary transport (GO:0042073)3.56794596
18ubiquinone metabolic process (GO:0006743)3.56400326
19preassembly of GPI anchor in ER membrane (GO:0016254)3.55878903
20tryptophan metabolic process (GO:0006568)3.55629934
21negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.54208330
22quinone biosynthetic process (GO:1901663)3.47762470
23GPI anchor metabolic process (GO:0006505)3.47479128
24neural tube formation (GO:0001841)3.46124843
25axoneme assembly (GO:0035082)3.44741413
26mitochondrial respiratory chain complex assembly (GO:0033108)3.42813301
27protein complex biogenesis (GO:0070271)3.42601190
28replication fork processing (GO:0031297)3.42342784
29photoreceptor cell maintenance (GO:0045494)3.40265342
30DNA integration (GO:0015074)3.36382122
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.26373188
32NADH dehydrogenase complex assembly (GO:0010257)3.26373188
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26373188
34cytochrome complex assembly (GO:0017004)3.19019068
35retinal cone cell development (GO:0046549)3.16388988
36respiratory chain complex IV assembly (GO:0008535)3.15420242
37cellular biogenic amine catabolic process (GO:0042402)3.13124841
38amine catabolic process (GO:0009310)3.13124841
39GPI anchor biosynthetic process (GO:0006506)3.12329127
40cilium movement (GO:0003341)3.10730882
41DNA double-strand break processing (GO:0000729)3.08406096
42glycerol ether metabolic process (GO:0006662)3.08253006
43DNA methylation involved in gamete generation (GO:0043046)3.02157290
44C4-dicarboxylate transport (GO:0015740)3.01947614
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01766376
46seminiferous tubule development (GO:0072520)3.00969648
47adult feeding behavior (GO:0008343)2.98463557
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98423751
49centriole replication (GO:0007099)2.98268122
50detection of light stimulus involved in sensory perception (GO:0050962)2.97104324
51detection of light stimulus involved in visual perception (GO:0050908)2.97104324
52GMP metabolic process (GO:0046037)2.89515986
53branched-chain amino acid catabolic process (GO:0009083)2.88611455
54ether metabolic process (GO:0018904)2.88307378
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88220542
56cilium or flagellum-dependent cell motility (GO:0001539)2.87955611
57nonmotile primary cilium assembly (GO:0035058)2.84446928
58C-terminal protein lipidation (GO:0006501)2.84439945
59cilium organization (GO:0044782)2.81405458
60protein polyglutamylation (GO:0018095)2.79268476
61cilium morphogenesis (GO:0060271)2.79246532
62male meiosis (GO:0007140)2.78028139
63spermatid development (GO:0007286)2.77753916
64cilium assembly (GO:0042384)2.76685822
65anterograde synaptic vesicle transport (GO:0048490)2.75286098
66glyoxylate metabolic process (GO:0046487)2.73638455
67regulation of microtubule-based movement (GO:0060632)2.70544687
68cellular ketone body metabolic process (GO:0046950)2.69219857
69aldehyde catabolic process (GO:0046185)2.68867033
70short-chain fatty acid metabolic process (GO:0046459)2.67540816
71cornea development in camera-type eye (GO:0061303)2.67480059
72sperm motility (GO:0030317)2.67351491
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66711828
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.66711828
75C-terminal protein amino acid modification (GO:0018410)2.65010032
76gamma-aminobutyric acid transport (GO:0015812)2.62839417
77DNA deamination (GO:0045006)2.62778590
78histone H2A acetylation (GO:0043968)2.61994371
79ncRNA catabolic process (GO:0034661)2.61844372
80aspartate family amino acid catabolic process (GO:0009068)2.61240495
81L-fucose catabolic process (GO:0042355)2.61171966
82fucose catabolic process (GO:0019317)2.61171966
83L-fucose metabolic process (GO:0042354)2.61171966
84negative regulation of cAMP-mediated signaling (GO:0043951)2.61145768
85adenosine metabolic process (GO:0046085)2.60897886
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58711464
87inositol phosphate catabolic process (GO:0071545)2.57601217
88glycolipid biosynthetic process (GO:0009247)2.56972109
89branched-chain amino acid metabolic process (GO:0009081)2.56443653
90protein K6-linked ubiquitination (GO:0085020)2.56031098
91synapsis (GO:0007129)2.54687695
92positive regulation of developmental pigmentation (GO:0048087)2.53638480
93mitochondrial RNA metabolic process (GO:0000959)2.53132972
94pyrimidine dimer repair (GO:0006290)2.51564392
95recombinational repair (GO:0000725)2.51510719
96estrogen biosynthetic process (GO:0006703)2.51427177
97thrombin receptor signaling pathway (GO:0070493)2.51194980
98regulation of MHC class II biosynthetic process (GO:0045346)2.50966054
99pyrimidine nucleotide catabolic process (GO:0006244)2.48678852
100double-strand break repair via homologous recombination (GO:0000724)2.47603747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.11734206
2IGF1R_20145208_ChIP-Seq_DFB_Human3.10806236
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89178961
4GBX2_23144817_ChIP-Seq_PC3_Human2.85353218
5TAF15_26573619_Chip-Seq_HEK293_Human2.83585599
6VDR_22108803_ChIP-Seq_LS180_Human2.78603214
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.72647662
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67930724
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44871397
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33102179
11FUS_26573619_Chip-Seq_HEK293_Human2.29768174
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27328218
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.26425550
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22886069
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.20241028
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16841994
17EWS_26573619_Chip-Seq_HEK293_Human2.15563655
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13976221
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09607691
20IRF1_19129219_ChIP-ChIP_H3396_Human2.01578330
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92600676
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90484661
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87612276
24P300_19829295_ChIP-Seq_ESCs_Human1.85922374
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83591057
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70945917
27CBP_20019798_ChIP-Seq_JUKART_Human1.70945917
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.67108752
29ER_23166858_ChIP-Seq_MCF-7_Human1.64948058
30MYC_18940864_ChIP-ChIP_HL60_Human1.64626473
31EZH2_22144423_ChIP-Seq_EOC_Human1.64143157
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61936777
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61936777
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60170858
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.57448828
36TP53_22573176_ChIP-Seq_HFKS_Human1.56559958
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56106542
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56040289
39VDR_23849224_ChIP-Seq_CD4+_Human1.55028513
40NANOG_19829295_ChIP-Seq_ESCs_Human1.48595633
41SOX2_19829295_ChIP-Seq_ESCs_Human1.48595633
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46794704
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.45489135
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45200328
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44570353
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.42296851
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41504345
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40002101
49ELK1_19687146_ChIP-ChIP_HELA_Human1.39296796
50BCAT_22108803_ChIP-Seq_LS180_Human1.36746442
51STAT3_23295773_ChIP-Seq_U87_Human1.35426581
52FOXP3_21729870_ChIP-Seq_TREG_Human1.33512441
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.28521426
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26229148
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25729782
56SMAD4_21799915_ChIP-Seq_A2780_Human1.24855073
57TCF4_23295773_ChIP-Seq_U87_Human1.24760379
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24153543
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23155502
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22952635
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21088265
62AR_25329375_ChIP-Seq_VCAP_Human1.17675652
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.14631271
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14463517
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14215723
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12569839
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.12569839
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11772351
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10389518
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09886402
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09042196
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08529041
73RUNX2_22187159_ChIP-Seq_PCA_Human1.07980013
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.07484987
75TCF4_22108803_ChIP-Seq_LS180_Human1.06957004
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05098549
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.04733666
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04173541
79NCOR_22424771_ChIP-Seq_293T_Human1.03601054
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.02829979
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.02481343
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02268998
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02173022
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00819465
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99853588
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.99468492
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99292202
88AR_20517297_ChIP-Seq_VCAP_Human0.99009624
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98442636
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98275423
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97830456
92E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96164747
93NANOG_20526341_ChIP-Seq_ESCs_Human0.95445162
94RNF2_27304074_Chip-Seq_NSC_Mouse0.95266995
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95214376
96SCL_19346495_ChIP-Seq_HPC-7_Human0.95061767
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93724649
98WDR5_24793694_ChIP-Seq_LNCAP_Human0.92976048
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91307772
100HOXB7_26014856_ChIP-Seq_BT474_Human0.90707363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.07020281
2MP0001968_abnormal_touch/_nociception2.93009287
3MP0009278_abnormal_bone_marrow2.88999558
4MP0008877_abnormal_DNA_methylation2.65950556
5MP0000015_abnormal_ear_pigmentation2.58752693
6MP0000372_irregular_coat_pigmentation2.51170688
7MP0005551_abnormal_eye_electrophysiolog2.50126291
8MP0008058_abnormal_DNA_repair2.49029945
9MP0002876_abnormal_thyroid_physiology2.24993760
10MP0003136_yellow_coat_color2.23334429
11MP0002638_abnormal_pupillary_reflex2.13539411
12MP0006292_abnormal_olfactory_placode2.12197336
13MP0003718_maternal_effect2.06737276
14MP0002102_abnormal_ear_morphology2.03324950
15MP0005075_abnormal_melanosome_morpholog2.01151651
16MP0005174_abnormal_tail_pigmentation1.99157381
17MP0005646_abnormal_pituitary_gland1.93067186
18MP0001986_abnormal_taste_sensitivity1.87423112
19MP0006276_abnormal_autonomic_nervous1.85640517
20MP0005645_abnormal_hypothalamus_physiol1.85141562
21MP0008995_early_reproductive_senescence1.79515782
22MP0008875_abnormal_xenobiotic_pharmacok1.78232839
23MP0000569_abnormal_digit_pigmentation1.76218312
24MP0002736_abnormal_nociception_after1.75187159
25MP0002095_abnormal_skin_pigmentation1.73664989
26MP0003195_calcinosis1.72465244
27MP0005397_hematopoietic_system_phenotyp1.69484800
28MP0001545_abnormal_hematopoietic_system1.69484800
29MP0006072_abnormal_retinal_apoptosis1.67101684
30MP0001529_abnormal_vocalization1.64676096
31MP0002938_white_spotting1.63687307
32MP0010094_abnormal_chromosome_stability1.62338461
33MP0001486_abnormal_startle_reflex1.60977554
34MP0006035_abnormal_mitochondrial_morpho1.60562981
35MP0002234_abnormal_pharynx_morphology1.54107021
36MP0002735_abnormal_chemical_nociception1.52646884
37MP0009046_muscle_twitch1.52126389
38MP0008872_abnormal_physiological_respon1.51273076
39MP0005253_abnormal_eye_physiology1.51166889
40MP0003787_abnormal_imprinting1.43062703
41MP0005410_abnormal_fertilization1.42741900
42MP0001984_abnormal_olfaction1.39695554
43MP0004043_abnormal_pH_regulation1.38050074
44MP0001501_abnormal_sleep_pattern1.36147132
45MP0002653_abnormal_ependyma_morphology1.31582429
46MP0004147_increased_porphyrin_level1.29445135
47MP0005171_absent_coat_pigmentation1.28700173
48MP0009745_abnormal_behavioral_response1.27341997
49MP0003806_abnormal_nucleotide_metabolis1.24088094
50MP0006036_abnormal_mitochondrial_physio1.23880405
51MP0003121_genomic_imprinting1.23829777
52MP0003698_abnormal_male_reproductive1.19276603
53MP0003122_maternal_imprinting1.17469293
54MP0001764_abnormal_homeostasis1.17271092
55MP0001929_abnormal_gametogenesis1.16284745
56MP0008789_abnormal_olfactory_epithelium1.12954411
57MP0000566_synostosis1.12542117
58MP0001905_abnormal_dopamine_level1.12112279
59MP0002272_abnormal_nervous_system1.09271851
60MP0010386_abnormal_urinary_bladder1.08875161
61MP0005423_abnormal_somatic_nervous1.07242387
62MP0002160_abnormal_reproductive_system1.03478315
63MP0002751_abnormal_autonomic_nervous0.99771062
64MP0009764_decreased_sensitivity_to0.99421865
65MP0002064_seizures0.97632361
66MP0000465_gastrointestinal_hemorrhage0.97133848
67MP0004133_heterotaxia0.95463471
68MP0005084_abnormal_gallbladder_morpholo0.95425541
69MP0000631_abnormal_neuroendocrine_gland0.94319989
70MP0002733_abnormal_thermal_nociception0.94314504
71MP0009697_abnormal_copulation0.93838158
72MP0001324_abnormal_eye_pigmentation0.93819566
73MP0001970_abnormal_pain_threshold0.91474758
74MP0001664_abnormal_digestion0.91373519
75MP0005085_abnormal_gallbladder_physiolo0.90656750
76MP0005195_abnormal_posterior_eye0.90579356
77MP0002067_abnormal_sensory_capabilities0.89990710
78MP0002557_abnormal_social/conspecific_i0.89433650
79MP0002572_abnormal_emotion/affect_behav0.87522440
80MP0005394_taste/olfaction_phenotype0.87402261
81MP0005499_abnormal_olfactory_system0.87402261
82MP0002282_abnormal_trachea_morphology0.86726653
83MP0004142_abnormal_muscle_tone0.86518272
84MP0005395_other_phenotype0.82118519
85MP0002210_abnormal_sex_determination0.82109816
86MP0000653_abnormal_sex_gland0.81638651
87MP0001963_abnormal_hearing_physiology0.80532582
88MP0002752_abnormal_somatic_nervous0.79900721
89MP0003646_muscle_fatigue0.78128977
90MP0003635_abnormal_synaptic_transmissio0.77886855
91MP0001145_abnormal_male_reproductive0.76618242
92MP0004742_abnormal_vestibular_system0.71263960
93MP0005389_reproductive_system_phenotype0.70359078
94MP0003567_abnormal_fetal_cardiomyocyte0.69430527
95MP0002069_abnormal_eating/drinking_beha0.69222525
96MP0000358_abnormal_cell_content/0.67990657
97MP0002837_dystrophic_cardiac_calcinosis0.67873432
98MP0001485_abnormal_pinna_reflex0.67319018
99MP0002229_neurodegeneration0.67227766
100MP0001293_anophthalmia0.66938691

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)4.42580672
2Pancreatic fibrosis (HP:0100732)3.77208531
3Pancreatic cysts (HP:0001737)3.74432789
4True hermaphroditism (HP:0010459)3.70511221
5Medial flaring of the eyebrow (HP:0010747)3.48693274
6Abnormality of midbrain morphology (HP:0002418)3.28873230
7Molar tooth sign on MRI (HP:0002419)3.28873230
8Focal motor seizures (HP:0011153)3.26018431
9Congenital stationary night blindness (HP:0007642)3.11918923
10Nephronophthisis (HP:0000090)3.05909392
11Hyperventilation (HP:0002883)3.04165511
12Congenital primary aphakia (HP:0007707)2.98416073
13Gait imbalance (HP:0002141)2.97854827
14Nephrogenic diabetes insipidus (HP:0009806)2.88393641
15Tubulointerstitial nephritis (HP:0001970)2.87647538
16Hepatocellular necrosis (HP:0001404)2.84976656
17Abnormal rod and cone electroretinograms (HP:0008323)2.68486417
18Inability to walk (HP:0002540)2.68239581
19Abnormality of the renal medulla (HP:0100957)2.67556268
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.63705904
21Intestinal atresia (HP:0011100)2.61878846
22Hyperglycinemia (HP:0002154)2.60630623
23Genital tract atresia (HP:0001827)2.60491022
24Cerebellar dysplasia (HP:0007033)2.59421066
25Progressive inability to walk (HP:0002505)2.58664454
26Volvulus (HP:0002580)2.58411741
27Attenuation of retinal blood vessels (HP:0007843)2.57663657
28Decreased central vision (HP:0007663)2.57075120
29Cystic liver disease (HP:0006706)2.54013460
30Type II lissencephaly (HP:0007260)2.53358869
31Hepatic necrosis (HP:0002605)2.52058277
32Abnormality of macular pigmentation (HP:0008002)2.50374825
33Type I transferrin isoform profile (HP:0003642)2.48521592
34Vaginal atresia (HP:0000148)2.48194360
35Absent speech (HP:0001344)2.47701994
36Hyperglycinuria (HP:0003108)2.45224365
37Colon cancer (HP:0003003)2.41113458
38Gaze-evoked nystagmus (HP:0000640)2.34912602
39Mitochondrial inheritance (HP:0001427)2.32747166
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31568000
41Abnormality of the ileum (HP:0001549)2.30156978
42Poor head control (HP:0002421)2.27908721
43Absent/shortened dynein arms (HP:0200106)2.26344646
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.26344646
45Increased CSF lactate (HP:0002490)2.25855972
46Abnormal protein glycosylation (HP:0012346)2.25333262
47Abnormal glycosylation (HP:0012345)2.25333262
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25333262
49Abnormal protein N-linked glycosylation (HP:0012347)2.25333262
50Short tibia (HP:0005736)2.23598363
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.23403720
52Postaxial foot polydactyly (HP:0001830)2.19024338
53Abnormality of the renal cortex (HP:0011035)2.18399096
54Abnormality of the labia minora (HP:0012880)2.17062265
55Lissencephaly (HP:0001339)2.16752158
56Congenital hepatic fibrosis (HP:0002612)2.16673302
57Acute encephalopathy (HP:0006846)2.16653775
58Renal cortical cysts (HP:0000803)2.15181371
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.14985114
60Methylmalonic acidemia (HP:0002912)2.14402250
61Methylmalonic aciduria (HP:0012120)2.13229917
62Abnormality of serine family amino acid metabolism (HP:0010894)2.13124317
63Abnormality of glycine metabolism (HP:0010895)2.13124317
64Chronic hepatic failure (HP:0100626)2.12649399
65Optic nerve hypoplasia (HP:0000609)2.12385478
66Chromsome breakage (HP:0040012)2.10152330
67Hypothermia (HP:0002045)2.09708133
68Tented upper lip vermilion (HP:0010804)2.07730991
69Astigmatism (HP:0000483)2.05174404
70Retinitis pigmentosa (HP:0000510)2.04804701
71Acute necrotizing encephalopathy (HP:0006965)2.04584992
72Broad-based gait (HP:0002136)2.03847445
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03779263
74Pendular nystagmus (HP:0012043)2.03518093
75Abnormal respiratory motile cilium morphology (HP:0005938)2.02889675
76Abnormal respiratory epithelium morphology (HP:0012253)2.02889675
77Abnormal ciliary motility (HP:0012262)1.97809381
78Male pseudohermaphroditism (HP:0000037)1.97331898
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95604086
80Retinal dysplasia (HP:0007973)1.95285039
81Sclerocornea (HP:0000647)1.94975920
82Anencephaly (HP:0002323)1.94351779
83Bony spicule pigmentary retinopathy (HP:0007737)1.93420911
84Optic disc pallor (HP:0000543)1.93391377
85Stomach cancer (HP:0012126)1.92972642
86Abnormal mitochondria in muscle tissue (HP:0008316)1.92887369
87Poor coordination (HP:0002370)1.92880223
88Abolished electroretinogram (ERG) (HP:0000550)1.92700478
89Increased corneal curvature (HP:0100692)1.91483877
90Keratoconus (HP:0000563)1.91483877
91Abnormal biliary tract physiology (HP:0012439)1.91252434
92Bile duct proliferation (HP:0001408)1.91252434
93Focal seizures (HP:0007359)1.89018613
94Pancreatic islet-cell hyperplasia (HP:0004510)1.88398063
95Abnormality of B cell number (HP:0010975)1.88023801
96Dialeptic seizures (HP:0011146)1.87926696
97Albinism (HP:0001022)1.87102697
98Postaxial hand polydactyly (HP:0001162)1.85163337
99Meckel diverticulum (HP:0002245)1.84990928
100Lipid accumulation in hepatocytes (HP:0006561)1.84151767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.07452252
2FRK3.75374140
3ADRBK23.36872781
4NUAK12.80437496
5VRK22.75481533
6WNK32.75273899
7PINK12.75219757
8BCKDK2.74856334
9ZAK2.63369663
10MAPK132.33631059
11MAP3K42.24312297
12MAP2K72.23339962
13NEK12.08726597
14TAOK32.05782875
15BMPR1B1.99451867
16TRIM281.91527988
17INSRR1.81565987
18CASK1.63455423
19CCNB11.58102197
20VRK11.49613805
21DYRK31.44318931
22MARK11.37558516
23FLT31.35754997
24CSNK1G31.29736243
25MKNK11.25601078
26EIF2AK31.24642056
27NEK21.24444828
28GRK11.18152185
29CSNK1G11.15838869
30CSNK1A1L1.15294982
31DYRK21.13404222
32CSNK1G21.12456755
33TAF11.12222149
34ADRBK11.09320239
35PLK21.08998130
36PLK41.04228705
37WEE10.98265503
38MAPKAPK50.92634257
39PRKCE0.91969254
40PNCK0.90048984
41PBK0.86218834
42ATR0.82885273
43TGFBR10.82120684
44BCR0.80347979
45TLK10.80280544
46STK38L0.79858355
47MKNK20.78452349
48PRKCG0.75617774
49PLK30.74041840
50PKN10.73834615
51EPHA40.73466946
52RPS6KA40.72205537
53BRSK20.71565417
54ACVR1B0.71324096
55SRPK10.70312212
56RPS6KA50.70018570
57TNK20.69825154
58FER0.67867515
59PIM20.67610259
60PAK30.67517030
61KIT0.67375675
62CDK30.65635352
63MARK30.65626168
64CDC70.63785554
65TEC0.61752635
66ERBB30.59668151
67PLK10.58715908
68TNIK0.57228844
69WNK40.54954620
70OXSR10.54187664
71DYRK1A0.53534034
72CSNK1A10.50681187
73CHEK20.50006442
74STK390.49580969
75MAP2K40.48895512
76ATM0.48034161
77PDK20.45025543
78IRAK10.44941146
79MAPKAPK30.44542050
80CAMK2A0.43791974
81NTRK20.39150222
82CLK10.38415457
83TIE10.37384787
84CAMK10.37372018
85PTK2B0.35424606
86PIK3CA0.34562079
87BRD40.33663129
88PRKACA0.32443637
89KDR0.30484172
90CSNK2A10.30258062
91AURKB0.29960509
92TTK0.29530796
93AKT30.29140917
94CSNK2A20.28940249
95GRK50.28884375
96STK160.28436022
97PRKCI0.28134023
98CSNK1D0.26662377
99PRKACB0.26615686
100EIF2AK20.25490285

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.13993731
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91412792
3Butanoate metabolism_Homo sapiens_hsa006502.91351282
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.84942361
5Fanconi anemia pathway_Homo sapiens_hsa034602.77121668
6Non-homologous end-joining_Homo sapiens_hsa034502.50574914
7Homologous recombination_Homo sapiens_hsa034402.50536506
8Phototransduction_Homo sapiens_hsa047442.37086444
9Propanoate metabolism_Homo sapiens_hsa006402.30105417
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21988782
11Base excision repair_Homo sapiens_hsa034102.20754004
12RNA polymerase_Homo sapiens_hsa030201.99242905
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97939819
14Nitrogen metabolism_Homo sapiens_hsa009101.82909985
15Basal transcription factors_Homo sapiens_hsa030221.74033276
16Peroxisome_Homo sapiens_hsa041461.69131514
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.67035779
18Tryptophan metabolism_Homo sapiens_hsa003801.63485724
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62315077
20Olfactory transduction_Homo sapiens_hsa047401.57827268
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56757882
22Oxidative phosphorylation_Homo sapiens_hsa001901.54992183
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53461965
24Linoleic acid metabolism_Homo sapiens_hsa005911.47210151
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.43008711
26Parkinsons disease_Homo sapiens_hsa050121.42954558
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37891206
28RNA degradation_Homo sapiens_hsa030181.35328924
29DNA replication_Homo sapiens_hsa030301.30015073
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27096093
31Ether lipid metabolism_Homo sapiens_hsa005651.26632830
32Mismatch repair_Homo sapiens_hsa034301.25914755
33Protein export_Homo sapiens_hsa030601.25688005
34Pyrimidine metabolism_Homo sapiens_hsa002401.24914627
35Taste transduction_Homo sapiens_hsa047421.24784492
36Purine metabolism_Homo sapiens_hsa002301.24283744
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21781533
38Caffeine metabolism_Homo sapiens_hsa002321.20332219
39Fatty acid elongation_Homo sapiens_hsa000621.18950196
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18768832
41One carbon pool by folate_Homo sapiens_hsa006701.17903178
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17898737
43Selenocompound metabolism_Homo sapiens_hsa004501.17542196
44Nicotine addiction_Homo sapiens_hsa050331.12490796
45ABC transporters_Homo sapiens_hsa020101.12011863
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.07837968
47Nucleotide excision repair_Homo sapiens_hsa034201.07328384
48Huntingtons disease_Homo sapiens_hsa050161.06006403
49Fatty acid degradation_Homo sapiens_hsa000711.04420791
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03971491
51Chemical carcinogenesis_Homo sapiens_hsa052041.02941788
52Proteasome_Homo sapiens_hsa030501.01153202
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00118887
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98569105
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.98548657
56Glutathione metabolism_Homo sapiens_hsa004800.97965509
57Fatty acid metabolism_Homo sapiens_hsa012120.95909545
58Regulation of autophagy_Homo sapiens_hsa041400.95830921
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91385521
60Metabolic pathways_Homo sapiens_hsa011000.90095478
61Arachidonic acid metabolism_Homo sapiens_hsa005900.88926917
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79265561
63RNA transport_Homo sapiens_hsa030130.79167108
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71761398
65Glycerolipid metabolism_Homo sapiens_hsa005610.66290729
66Retinol metabolism_Homo sapiens_hsa008300.65504087
67beta-Alanine metabolism_Homo sapiens_hsa004100.60395320
68Alzheimers disease_Homo sapiens_hsa050100.59704180
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59427070
70Dorso-ventral axis formation_Homo sapiens_hsa043200.56676307
71Primary immunodeficiency_Homo sapiens_hsa053400.55118377
72Carbon metabolism_Homo sapiens_hsa012000.55103442
73Ovarian steroidogenesis_Homo sapiens_hsa049130.53964023
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50880230
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50232876
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49548676
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49374152
78Lysine degradation_Homo sapiens_hsa003100.49204320
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.48980750
80Pyruvate metabolism_Homo sapiens_hsa006200.48139449
81Spliceosome_Homo sapiens_hsa030400.46799160
82Morphine addiction_Homo sapiens_hsa050320.46352539
83Asthma_Homo sapiens_hsa053100.45522148
84Sphingolipid metabolism_Homo sapiens_hsa006000.45430564
85Steroid biosynthesis_Homo sapiens_hsa001000.45280243
86Pentose phosphate pathway_Homo sapiens_hsa000300.45174562
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.44383752
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44267098
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.43332759
90Biosynthesis of amino acids_Homo sapiens_hsa012300.42385844
91Collecting duct acid secretion_Homo sapiens_hsa049660.39678916
92Tyrosine metabolism_Homo sapiens_hsa003500.39632803
93Salivary secretion_Homo sapiens_hsa049700.38676488
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38146631
95Hedgehog signaling pathway_Homo sapiens_hsa043400.36858489
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34792739
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34780079
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34185838
99Vitamin digestion and absorption_Homo sapiens_hsa049770.33326649
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32723057

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