SPDYE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomere maintenance (GO:0032205)4.25163555
2mannosylation (GO:0097502)4.21354641
3DNA deamination (GO:0045006)3.86007544
4cellular response to exogenous dsRNA (GO:0071360)3.79588787
5piRNA metabolic process (GO:0034587)3.76386796
6preassembly of GPI anchor in ER membrane (GO:0016254)3.75048815
7mismatch repair (GO:0006298)3.69370022
8protein polyglutamylation (GO:0018095)3.66574961
9base-excision repair, AP site formation (GO:0006285)3.52351781
10regulation of telomere maintenance (GO:0032204)3.47461560
11centriole replication (GO:0007099)3.33850424
12regulation of cilium movement (GO:0003352)3.33645868
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32753014
14seminiferous tubule development (GO:0072520)3.24106127
15behavioral response to nicotine (GO:0035095)3.22465379
16fucose catabolic process (GO:0019317)3.22132175
17L-fucose metabolic process (GO:0042354)3.22132175
18L-fucose catabolic process (GO:0042355)3.22132175
19GPI anchor metabolic process (GO:0006505)3.18628614
20rRNA catabolic process (GO:0016075)3.15761348
21DNA double-strand break processing (GO:0000729)3.14913649
22ubiquinone biosynthetic process (GO:0006744)3.08089847
23DNA methylation involved in gamete generation (GO:0043046)3.07568407
24axoneme assembly (GO:0035082)3.06285994
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05785146
26pyrimidine nucleotide catabolic process (GO:0006244)3.04637592
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.03476138
28NADH dehydrogenase complex assembly (GO:0010257)3.03476138
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03476138
30recombinational repair (GO:0000725)2.99916850
31indolalkylamine metabolic process (GO:0006586)2.98944787
32replication fork processing (GO:0031297)2.98654537
33autophagic vacuole fusion (GO:0000046)2.98090967
34GPI anchor biosynthetic process (GO:0006506)2.98038032
35double-strand break repair via homologous recombination (GO:0000724)2.97991523
36histone H3-K9 methylation (GO:0051567)2.97817415
37protein complex biogenesis (GO:0070271)2.93191748
38indole-containing compound catabolic process (GO:0042436)2.86053500
39indolalkylamine catabolic process (GO:0046218)2.86053500
40tryptophan catabolic process (GO:0006569)2.86053500
41ubiquinone metabolic process (GO:0006743)2.84207396
42photoreceptor cell maintenance (GO:0045494)2.83953741
43cellular ketone body metabolic process (GO:0046950)2.83185012
44C-terminal protein lipidation (GO:0006501)2.82867639
45detection of light stimulus involved in visual perception (GO:0050908)2.82826070
46detection of light stimulus involved in sensory perception (GO:0050962)2.82826070
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81171495
48regulation of nuclear cell cycle DNA replication (GO:0033262)2.80999782
49tryptophan metabolic process (GO:0006568)2.80836272
50peptidyl-histidine modification (GO:0018202)2.79634078
51branched-chain amino acid catabolic process (GO:0009083)2.78352699
52DNA modification (GO:0006304)2.77661285
53respiratory chain complex IV assembly (GO:0008535)2.77580678
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77414853
55deoxyribonucleotide catabolic process (GO:0009264)2.76632784
56nonmotile primary cilium assembly (GO:0035058)2.73900329
57cytochrome complex assembly (GO:0017004)2.72336278
58reciprocal meiotic recombination (GO:0007131)2.71290913
59reciprocal DNA recombination (GO:0035825)2.71290913
60cell wall macromolecule metabolic process (GO:0044036)2.71275921
61mitochondrial respiratory chain complex assembly (GO:0033108)2.70615308
62iron-sulfur cluster assembly (GO:0016226)2.70063818
63metallo-sulfur cluster assembly (GO:0031163)2.70063818
64anterograde synaptic vesicle transport (GO:0048490)2.69698173
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69141571
66neural tube formation (GO:0001841)2.68917311
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68842265
68tRNA modification (GO:0006400)2.68458586
69kynurenine metabolic process (GO:0070189)2.68267394
70positive regulation of mitochondrial fission (GO:0090141)2.67153875
71inositol phosphate catabolic process (GO:0071545)2.66945788
72phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65644598
73amino acid salvage (GO:0043102)2.65489968
74L-methionine salvage (GO:0071267)2.65489968
75L-methionine biosynthetic process (GO:0071265)2.65489968
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65434231
77purine deoxyribonucleotide catabolic process (GO:0009155)2.62366583
78DNA demethylation (GO:0080111)2.61553533
79DNA integration (GO:0015074)2.60610947
80positive regulation of developmental pigmentation (GO:0048087)2.60446910
81branched-chain amino acid metabolic process (GO:0009081)2.59255685
82intraciliary transport (GO:0042073)2.58650890
83ketone body metabolic process (GO:1902224)2.58079524
84epithelial cilium movement (GO:0003351)2.57503631
85pyrimidine dimer repair (GO:0006290)2.57474359
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57205570
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57205570
88regulation of rhodopsin mediated signaling pathway (GO:0022400)2.56943501
89cilium or flagellum-dependent cell motility (GO:0001539)2.55499863
90platelet dense granule organization (GO:0060155)2.54652052
91phosphorylated carbohydrate dephosphorylation (GO:0046838)2.52357859
92inositol phosphate dephosphorylation (GO:0046855)2.52357859
93positive regulation of granulocyte differentiation (GO:0030854)2.50883527
94actin nucleation (GO:0045010)2.50812775
95DNA methylation or demethylation (GO:0044728)2.50536857
96deoxyribose phosphate catabolic process (GO:0046386)2.49948398
97organelle membrane fusion (GO:0090174)2.49419898
98arginine catabolic process (GO:0006527)2.48031917
99cilium organization (GO:0044782)2.47851946
100maturation of 5.8S rRNA (GO:0000460)2.47494302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.74676008
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00988233
3HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94152386
4EZH2_22144423_ChIP-Seq_EOC_Human2.90045920
5IGF1R_20145208_ChIP-Seq_DFB_Human2.72771954
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55564174
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.54044646
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.47296529
9VDR_22108803_ChIP-Seq_LS180_Human2.45198931
10CIITA_25753668_ChIP-Seq_RAJI_Human2.34366308
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.33192848
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.26077696
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20148040
14VDR_23849224_ChIP-Seq_CD4+_Human2.15006196
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14580259
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13706535
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05508316
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03214455
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02603796
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01697426
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.95817134
22FOXP3_21729870_ChIP-Seq_TREG_Human1.85366884
23TP53_22573176_ChIP-Seq_HFKS_Human1.80838748
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.77602701
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73151455
26SCL_19346495_ChIP-Seq_HPC-7_Human1.73085727
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70553764
28MYC_18940864_ChIP-ChIP_HL60_Human1.67963448
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67698107
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64494215
31IRF1_19129219_ChIP-ChIP_H3396_Human1.64391997
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59187017
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58104013
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57682980
35ER_23166858_ChIP-Seq_MCF-7_Human1.55078898
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.54673138
37GBX2_23144817_ChIP-Seq_PC3_Human1.51288719
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48157155
39EWS_26573619_Chip-Seq_HEK293_Human1.45628186
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44123096
41GABP_19822575_ChIP-Seq_HepG2_Human1.43179301
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42897257
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36102163
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.35546852
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33786620
46CBP_20019798_ChIP-Seq_JUKART_Human1.33786620
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.31946014
48ERA_21632823_ChIP-Seq_H3396_Human1.30500205
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27665786
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25836027
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24873277
52* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23803057
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22926408
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.22778061
55GATA3_26560356_Chip-Seq_TH2_Human1.21755105
56AR_20517297_ChIP-Seq_VCAP_Human1.20222643
57HOXB7_26014856_ChIP-Seq_BT474_Human1.16975220
58FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15742649
59NCOR_22424771_ChIP-Seq_293T_Human1.15523607
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14822974
61FUS_26573619_Chip-Seq_HEK293_Human1.14106794
62ELK1_19687146_ChIP-ChIP_HELA_Human1.13320058
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12294677
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10184666
65MYC_19829295_ChIP-Seq_ESCs_Human1.09893175
66NANOG_20526341_ChIP-Seq_ESCs_Human1.08620389
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.07164903
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07164903
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07060441
70GATA3_27048872_Chip-Seq_THYMUS_Human1.05488994
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04701240
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04701240
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02925168
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02398383
75KDM5A_27292631_Chip-Seq_BREAST_Human1.02380295
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.00693745
77TAF15_26573619_Chip-Seq_HEK293_Human1.00295928
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99990201
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99553883
80* BCL6_27268052_Chip-Seq_Bcells_Human0.99097466
81REST_21632747_ChIP-Seq_MESCs_Mouse0.98460332
82OCT4_20526341_ChIP-Seq_ESCs_Human0.97647139
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97186785
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96995900
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96972813
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96416294
87TCF4_23295773_ChIP-Seq_U87_Human0.96318408
88P300_19829295_ChIP-Seq_ESCs_Human0.95819493
89TAF2_19829295_ChIP-Seq_ESCs_Human0.95589785
90STAT3_23295773_ChIP-Seq_U87_Human0.94829729
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.94568302
92* RAC3_21632823_ChIP-Seq_H3396_Human0.94259908
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93486313
94E2F1_20622854_ChIP-Seq_HELA_Human0.93353045
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93341584
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93151026
97CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92928274
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.91221121
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90366774
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90208609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.04649661
2MP0008877_abnormal_DNA_methylation2.76309911
3MP0005645_abnormal_hypothalamus_physiol2.61328047
4MP0003787_abnormal_imprinting2.59550715
5MP0005075_abnormal_melanosome_morpholog2.38807549
6MP0008058_abnormal_DNA_repair2.27412486
7MP0002102_abnormal_ear_morphology2.24005868
8MP0006292_abnormal_olfactory_placode2.17678307
9MP0003880_abnormal_central_pattern2.14256136
10MP0001986_abnormal_taste_sensitivity2.11583599
11MP0006072_abnormal_retinal_apoptosis2.07634519
12MP0000372_irregular_coat_pigmentation2.04887338
13MP0005551_abnormal_eye_electrophysiolog2.04368536
14MP0005646_abnormal_pituitary_gland1.99263625
15MP0000569_abnormal_digit_pigmentation1.97285204
16MP0004043_abnormal_pH_regulation1.96664645
17MP0001968_abnormal_touch/_nociception1.91542234
18MP0004145_abnormal_muscle_electrophysio1.88885140
19MP0003646_muscle_fatigue1.75862970
20MP0005253_abnormal_eye_physiology1.69264637
21MP0002822_catalepsy1.68003591
22MP0000015_abnormal_ear_pigmentation1.67131275
23MP0006276_abnormal_autonomic_nervous1.67031331
24MP0009278_abnormal_bone_marrow1.60924439
25MP0008872_abnormal_physiological_respon1.59083682
26MP0002095_abnormal_skin_pigmentation1.55485344
27MP0005394_taste/olfaction_phenotype1.44199172
28MP0005499_abnormal_olfactory_system1.44199172
29MP0002736_abnormal_nociception_after1.43691903
30MP0005174_abnormal_tail_pigmentation1.42630382
31MP0004142_abnormal_muscle_tone1.42507683
32MP0008789_abnormal_olfactory_epithelium1.41584655
33MP0010094_abnormal_chromosome_stability1.34016634
34MP0002735_abnormal_chemical_nociception1.32810933
35MP0001545_abnormal_hematopoietic_system1.32314005
36MP0005397_hematopoietic_system_phenotyp1.32314005
37MP0003121_genomic_imprinting1.32141181
38MP0008995_early_reproductive_senescence1.31850436
39MP0001984_abnormal_olfaction1.27940964
40MP0009046_muscle_twitch1.27891754
41MP0001800_abnormal_humoral_immune1.24831750
42MP0001835_abnormal_antigen_presentation1.23531692
43MP0002837_dystrophic_cardiac_calcinosis1.22802159
44MP0008875_abnormal_xenobiotic_pharmacok1.22392273
45MP0003718_maternal_effect1.22174833
46MP0005671_abnormal_response_to1.21553248
47MP0002138_abnormal_hepatobiliary_system1.20604636
48MP0001905_abnormal_dopamine_level1.14767849
49MP0000631_abnormal_neuroendocrine_gland1.14436860
50MP0004147_increased_porphyrin_level1.13563748
51MP0002733_abnormal_thermal_nociception1.13314801
52MP0002557_abnormal_social/conspecific_i1.11306348
53MP0001486_abnormal_startle_reflex1.10731864
54MP0003122_maternal_imprinting1.10416717
55MP0009745_abnormal_behavioral_response1.08355525
56MP0002938_white_spotting1.07729388
57MP0000465_gastrointestinal_hemorrhage1.07631992
58MP0005423_abnormal_somatic_nervous1.06548664
59MP0003786_premature_aging1.04821943
60MP0001764_abnormal_homeostasis1.03304204
61MP0001929_abnormal_gametogenesis1.01451764
62MP0002272_abnormal_nervous_system1.00287606
63MP0003698_abnormal_male_reproductive0.98597980
64MP0006036_abnormal_mitochondrial_physio0.97844546
65MP0001970_abnormal_pain_threshold0.96743736
66MP0001501_abnormal_sleep_pattern0.95755637
67MP0000689_abnormal_spleen_morphology0.95047682
68MP0002572_abnormal_emotion/affect_behav0.94618209
69MP0000427_abnormal_hair_cycle0.91741594
70MP0004133_heterotaxia0.91400611
71MP0002751_abnormal_autonomic_nervous0.90887292
72MP0002398_abnormal_bone_marrow0.87473672
73MP0002234_abnormal_pharynx_morphology0.87335494
74MP0001529_abnormal_vocalization0.87179741
75MP0002723_abnormal_immune_serum0.86681109
76MP0002420_abnormal_adaptive_immunity0.85253596
77MP0002210_abnormal_sex_determination0.85090325
78MP0002752_abnormal_somatic_nervous0.84553512
79MP0006035_abnormal_mitochondrial_morpho0.84551698
80MP0003136_yellow_coat_color0.84449941
81MP0001819_abnormal_immune_cell0.83450922
82MP0002067_abnormal_sensory_capabilities0.83057808
83MP0004924_abnormal_behavior0.82116003
84MP0005386_behavior/neurological_phenoty0.82116003
85MP0002928_abnormal_bile_duct0.82099918
86MP0003195_calcinosis0.81552825
87MP0005195_abnormal_posterior_eye0.80927107
88MP0000778_abnormal_nervous_system0.80421779
89MP0002452_abnormal_antigen_presenting0.80325793
90MP0005410_abnormal_fertilization0.80095474
91MP0003045_fibrosis0.78118896
92MP0004381_abnormal_hair_follicle0.77911117
93MP0000653_abnormal_sex_gland0.77795074
94MP0000716_abnormal_immune_system0.77750373
95MP0005171_absent_coat_pigmentation0.77582395
96MP0001324_abnormal_eye_pigmentation0.76787413
97MP0001145_abnormal_male_reproductive0.76150057
98MP0002396_abnormal_hematopoietic_system0.75854165
99MP0003635_abnormal_synaptic_transmissio0.75818832
100MP0003763_abnormal_thymus_physiology0.75664130

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.90630904
2Congenital stationary night blindness (HP:0007642)3.66121169
3Nephronophthisis (HP:0000090)3.63262145
4Pancreatic fibrosis (HP:0100732)3.56495067
5Panhypogammaglobulinemia (HP:0003139)3.36851211
6True hermaphroditism (HP:0010459)3.32509887
7Molar tooth sign on MRI (HP:0002419)3.29673555
8Abnormality of midbrain morphology (HP:0002418)3.29673555
9Medial flaring of the eyebrow (HP:0010747)3.28243927
10Abnormality of the renal medulla (HP:0100957)3.24562024
11Abnormality of the renal cortex (HP:0011035)3.24290998
12Tubulointerstitial nephritis (HP:0001970)2.78823176
13Attenuation of retinal blood vessels (HP:0007843)2.71605504
14Cystic liver disease (HP:0006706)2.70106686
15Hepatocellular necrosis (HP:0001404)2.69626328
16Chronic hepatic failure (HP:0100626)2.68413651
17Gait imbalance (HP:0002141)2.65164465
18Genetic anticipation (HP:0003743)2.63967785
193-Methylglutaconic aciduria (HP:0003535)2.62441578
20Renal cortical cysts (HP:0000803)2.62008723
21Abnormal rod and cone electroretinograms (HP:0008323)2.55979139
22Congenital primary aphakia (HP:0007707)2.54565028
23Nephrogenic diabetes insipidus (HP:0009806)2.49045129
24Mitochondrial inheritance (HP:0001427)2.48628186
25Abnormality of DNA repair (HP:0003254)2.47268021
26Hepatic necrosis (HP:0002605)2.46017166
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44312063
28Type I transferrin isoform profile (HP:0003642)2.44276964
29Type II lissencephaly (HP:0007260)2.42459402
30Pachygyria (HP:0001302)2.35886562
31Decreased central vision (HP:0007663)2.32960227
32Bile duct proliferation (HP:0001408)2.32387695
33Abnormal biliary tract physiology (HP:0012439)2.32387695
34Congenital hepatic fibrosis (HP:0002612)2.28180869
35Increased CSF lactate (HP:0002490)2.26831303
36Lissencephaly (HP:0001339)2.23047849
37Progressive cerebellar ataxia (HP:0002073)2.21544424
38Cerebellar dysplasia (HP:0007033)2.21165954
39Abnormality of B cell number (HP:0010975)2.20869793
40Stomach cancer (HP:0012126)2.20571459
41Elevated erythrocyte sedimentation rate (HP:0003565)2.20180984
42Acute necrotizing encephalopathy (HP:0006965)2.18679128
43Hyperventilation (HP:0002883)2.18388994
44Inability to walk (HP:0002540)2.18111707
45Severe combined immunodeficiency (HP:0004430)2.17853153
46Abnormal protein glycosylation (HP:0012346)2.17590238
47Abnormal glycosylation (HP:0012345)2.17590238
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17590238
49Abnormal protein N-linked glycosylation (HP:0012347)2.17590238
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16608820
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.14853188
52Retinal dysplasia (HP:0007973)2.14830446
53Tubular atrophy (HP:0000092)2.14542152
54Absent thumb (HP:0009777)2.13923997
55Abnormal mitochondria in muscle tissue (HP:0008316)2.11913776
56Colon cancer (HP:0003003)2.09274469
57Abolished electroretinogram (ERG) (HP:0000550)2.05972703
58Progressive microcephaly (HP:0000253)2.04103639
59Agammaglobulinemia (HP:0004432)2.02994820
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.02271569
61Dicarboxylic aciduria (HP:0003215)1.97934679
62Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97934679
63Tented upper lip vermilion (HP:0010804)1.97377938
64Poor coordination (HP:0002370)1.96713893
65Progressive inability to walk (HP:0002505)1.96289880
66Acute encephalopathy (HP:0006846)1.95600929
67Abnormal number of erythroid precursors (HP:0012131)1.95240399
68Severe visual impairment (HP:0001141)1.94490933
69Lipid accumulation in hepatocytes (HP:0006561)1.94175063
70Postaxial foot polydactyly (HP:0001830)1.93841106
71Absent speech (HP:0001344)1.91903117
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.91582956
73Methylmalonic acidemia (HP:0002912)1.90049939
74Ketosis (HP:0001946)1.88574266
75Tubulointerstitial abnormality (HP:0001969)1.88568054
76Sclerocornea (HP:0000647)1.87074434
77IgG deficiency (HP:0004315)1.87073427
78Anencephaly (HP:0002323)1.86883267
79Patellar aplasia (HP:0006443)1.84138134
80Focal motor seizures (HP:0011153)1.83478572
81Retinitis pigmentosa (HP:0000510)1.82920067
82B lymphocytopenia (HP:0010976)1.82547108
83Abnormal delayed hypersensitivity skin test (HP:0002963)1.80815713
84Neutropenia (HP:0001875)1.80556768
85Chromsome breakage (HP:0040012)1.79626352
86Polydipsia (HP:0001959)1.79111947
87Abnormal drinking behavior (HP:0030082)1.79111947
88Broad-based gait (HP:0002136)1.78107300
89Methylmalonic aciduria (HP:0012120)1.77822174
90Increased hepatocellular lipid droplets (HP:0006565)1.77580432
91Increased serum lactate (HP:0002151)1.77428014
92Progressive macrocephaly (HP:0004481)1.76885047
93Eosinophilia (HP:0001880)1.75106535
94Prominent nasal bridge (HP:0000426)1.74119475
95Sloping forehead (HP:0000340)1.73501345
96Aganglionic megacolon (HP:0002251)1.72753897
97Clubbing of toes (HP:0100760)1.71509503
98Aplasia/Hypoplasia of the patella (HP:0006498)1.71025814
99Pendular nystagmus (HP:0012043)1.71024143
100Granulocytopenia (HP:0001913)1.70416204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.78768368
2FRK4.04837497
3MAP4K23.72686458
4NUAK13.12209249
5BCKDK2.94155825
6VRK22.16908844
7MAP3K42.16640383
8BMPR1B2.00299313
9WNK31.98927745
10STK161.94186921
11MAPK131.93301064
12ZAK1.90677022
13WNK41.90624722
14MAP4K11.79093215
15MAP2K71.77532988
16KIT1.72891734
17TRIM281.63702526
18TNK21.59272259
19ADRBK21.51106413
20INSRR1.46854236
21MAPKAPK31.45524050
22CSNK1A1L1.44100747
23TESK21.36182129
24SYK1.32039926
25GRK11.31722585
26CSNK1G31.29372281
27NME11.28218288
28TXK1.27215944
29NEK21.25188928
30ATR1.24771550
31MUSK1.23648913
32MARK11.16778686
33BTK1.14400543
34TEC1.12879648
35CSNK1G21.11907098
36PLK41.03743795
37DYRK21.02223941
38FLT31.00592553
39KDR0.95310277
40IKBKB0.93712865
41VRK10.93497488
42ITK0.93460317
43CSNK1G10.89818822
44TLK10.89481639
45DAPK10.87558375
46CCNB10.84913328
47LATS10.83838928
48PIK3CA0.81777369
49CDK190.76049327
50PINK10.74897045
51PTK2B0.74646865
52DAPK20.72910723
53GRK60.72206689
54SIK20.72158969
55LCK0.70268322
56CDK80.70167238
57MAPKAPK50.68797267
58MAPK150.67583551
59TNIK0.65501085
60CDK30.63600770
61ADRBK10.63546133
62PRKCQ0.62472219
63OXSR10.61113445
64MAP3K60.61003448
65MAP2K20.59916263
66MAPK110.55748043
67LYN0.55571969
68STK390.54570770
69BCR0.53488854
70IKBKE0.51100350
71MARK30.49011020
72FES0.48871765
73PRKCG0.48823411
74CDC70.48636489
75OBSCN0.46035356
76MAP2K60.45381541
77CAMK10.44901938
78SRPK10.43851490
79MAP2K40.43146808
80MAPK30.42154967
81EPHA30.41322424
82CSF1R0.40665390
83PHKG20.40579262
84PHKG10.40579262
85RPS6KA50.40056684
86CSNK1A10.39748439
87CHEK20.39650256
88ATM0.38685371
89PRKACA0.38365040
90SCYL20.38254294
91CSNK1D0.38118899
92PRKAA10.37371547
93PAK30.37250591
94TBK10.35877351
95PLK10.34022539
96NTRK20.33391150
97CASK0.33219605
98ABL10.32018811
99CDK90.31598196
100CHUK0.30082703

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.61677204
2Fanconi anemia pathway_Homo sapiens_hsa034602.83366839
3Phototransduction_Homo sapiens_hsa047442.78392546
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.61848606
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59971651
6Primary immunodeficiency_Homo sapiens_hsa053402.55963183
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.50089158
8RNA polymerase_Homo sapiens_hsa030202.49317622
9Asthma_Homo sapiens_hsa053102.44740148
10Homologous recombination_Homo sapiens_hsa034402.37519516
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26118499
12Butanoate metabolism_Homo sapiens_hsa006502.21372251
13Linoleic acid metabolism_Homo sapiens_hsa005912.14467612
14Base excision repair_Homo sapiens_hsa034102.05015287
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02265047
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84500816
17Allograft rejection_Homo sapiens_hsa053301.82969793
18Graft-versus-host disease_Homo sapiens_hsa053321.82609177
19Peroxisome_Homo sapiens_hsa041461.81420307
20Oxidative phosphorylation_Homo sapiens_hsa001901.80001778
21Autoimmune thyroid disease_Homo sapiens_hsa053201.77566709
22Non-homologous end-joining_Homo sapiens_hsa034501.71888471
23RNA degradation_Homo sapiens_hsa030181.67463423
24Type I diabetes mellitus_Homo sapiens_hsa049401.63169724
25Regulation of autophagy_Homo sapiens_hsa041401.60043097
26Ether lipid metabolism_Homo sapiens_hsa005651.59418285
27Nitrogen metabolism_Homo sapiens_hsa009101.53210514
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52974189
29Parkinsons disease_Homo sapiens_hsa050121.52189571
30Pyrimidine metabolism_Homo sapiens_hsa002401.31576091
31Propanoate metabolism_Homo sapiens_hsa006401.30433705
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29370744
33Nicotine addiction_Homo sapiens_hsa050331.15800127
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15166243
35Basal transcription factors_Homo sapiens_hsa030221.12236406
36Olfactory transduction_Homo sapiens_hsa047401.09665631
37Purine metabolism_Homo sapiens_hsa002301.07255969
38Huntingtons disease_Homo sapiens_hsa050161.07104972
39Proteasome_Homo sapiens_hsa030501.05391739
40Taste transduction_Homo sapiens_hsa047421.01604549
41Nucleotide excision repair_Homo sapiens_hsa034200.96222806
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95409898
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94632973
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92754896
45One carbon pool by folate_Homo sapiens_hsa006700.91920983
46Lysine degradation_Homo sapiens_hsa003100.89958623
47Arachidonic acid metabolism_Homo sapiens_hsa005900.87076268
48Mismatch repair_Homo sapiens_hsa034300.85508714
49Tryptophan metabolism_Homo sapiens_hsa003800.83520176
50RNA transport_Homo sapiens_hsa030130.81589904
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81443665
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81318162
53Ribosome_Homo sapiens_hsa030100.77182842
54Antigen processing and presentation_Homo sapiens_hsa046120.77016891
55Protein export_Homo sapiens_hsa030600.74382614
56Morphine addiction_Homo sapiens_hsa050320.74204696
57Alzheimers disease_Homo sapiens_hsa050100.72270425
58Sulfur relay system_Homo sapiens_hsa041220.72100971
59DNA replication_Homo sapiens_hsa030300.66955915
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65201908
61Chemical carcinogenesis_Homo sapiens_hsa052040.64564131
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.64165181
63Collecting duct acid secretion_Homo sapiens_hsa049660.63103021
64ABC transporters_Homo sapiens_hsa020100.62170918
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61870675
66Viral myocarditis_Homo sapiens_hsa054160.61513132
67Metabolic pathways_Homo sapiens_hsa011000.60156634
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59634248
69Hematopoietic cell lineage_Homo sapiens_hsa046400.59563452
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59117349
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58484048
72Spliceosome_Homo sapiens_hsa030400.56863304
73GABAergic synapse_Homo sapiens_hsa047270.55203559
74Rheumatoid arthritis_Homo sapiens_hsa053230.54947178
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53439020
76Cardiac muscle contraction_Homo sapiens_hsa042600.53321104
77Salivary secretion_Homo sapiens_hsa049700.53110572
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52900955
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52288182
80Herpes simplex infection_Homo sapiens_hsa051680.50430437
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.48076476
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46672237
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46667472
84Calcium signaling pathway_Homo sapiens_hsa040200.44320703
85Dorso-ventral axis formation_Homo sapiens_hsa043200.43617171
86beta-Alanine metabolism_Homo sapiens_hsa004100.43539959
87Circadian entrainment_Homo sapiens_hsa047130.43375764
88Glycerolipid metabolism_Homo sapiens_hsa005610.42988574
89Fatty acid elongation_Homo sapiens_hsa000620.40967888
90Fatty acid metabolism_Homo sapiens_hsa012120.40080631
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.38710858
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37849974
93Caffeine metabolism_Homo sapiens_hsa002320.36904501
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35745495
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.35713862
96Epstein-Barr virus infection_Homo sapiens_hsa051690.33836785
97* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33720070
98Serotonergic synapse_Homo sapiens_hsa047260.33678466
99Glutamatergic synapse_Homo sapiens_hsa047240.31389038
100Fatty acid degradation_Homo sapiens_hsa000710.28381227

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