SPDYE2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.84754278
2establishment of protein localization to Golgi (GO:0072600)6.21623448
3protein targeting to Golgi (GO:0000042)6.17575688
4retrograde transport, vesicle recycling within Golgi (GO:0000301)5.82985663
5maintenance of gastrointestinal epithelium (GO:0030277)5.62942032
6protein localization to Golgi apparatus (GO:0034067)4.75361104
7L-fucose catabolic process (GO:0042355)4.45705365
8fucose catabolic process (GO:0019317)4.45705365
9L-fucose metabolic process (GO:0042354)4.45705365
10multicellular organism reproduction (GO:0032504)4.43169681
11regulation of glucokinase activity (GO:0033131)4.41705166
12regulation of hexokinase activity (GO:1903299)4.41705166
13tryptophan catabolic process (GO:0006569)4.39249020
14indole-containing compound catabolic process (GO:0042436)4.39249020
15indolalkylamine catabolic process (GO:0046218)4.39249020
16kynurenine metabolic process (GO:0070189)4.06384557
17tryptophan metabolic process (GO:0006568)4.02416243
18centriole replication (GO:0007099)4.01452830
19positive regulation of granulocyte differentiation (GO:0030854)3.99067568
20mannosylation (GO:0097502)3.88640736
21epithelial structure maintenance (GO:0010669)3.86460598
22sperm motility (GO:0030317)3.77103807
23piRNA metabolic process (GO:0034587)3.76109025
24NAD biosynthetic process (GO:0009435)3.73158486
25positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.68496432
26regulation of ARF GTPase activity (GO:0032312)3.63927795
27cellular response to exogenous dsRNA (GO:0071360)3.58698595
28O-glycan processing (GO:0016266)3.54782649
29DNA methylation involved in gamete generation (GO:0043046)3.41260041
30rRNA catabolic process (GO:0016075)3.34454049
31preassembly of GPI anchor in ER membrane (GO:0016254)3.33852107
32regulation of MHC class I biosynthetic process (GO:0045343)3.32105118
33indolalkylamine metabolic process (GO:0006586)3.31221689
34double-strand break repair via homologous recombination (GO:0000724)3.29537953
35nephron epithelium morphogenesis (GO:0072088)3.29491520
36nephron tubule morphogenesis (GO:0072078)3.29491520
37intra-Golgi vesicle-mediated transport (GO:0006891)3.26004327
38rRNA modification (GO:0000154)3.25809168
39recombinational repair (GO:0000725)3.23986126
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23241770
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23241770
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.23241770
43acrosome reaction (GO:0007340)3.21135681
44rRNA methylation (GO:0031167)3.17884377
45replication fork processing (GO:0031297)3.16867533
46centriole assembly (GO:0098534)3.16366188
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.15925676
48regulation of granulocyte differentiation (GO:0030852)3.14484768
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14104694
50regulation of G0 to G1 transition (GO:0070316)3.09958159
51photoreceptor cell maintenance (GO:0045494)3.08996842
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.07041966
53cilium or flagellum-dependent cell motility (GO:0001539)3.02949860
54detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.02722372
55negative regulation of multicellular organism growth (GO:0040015)2.98379191
56DNA catabolic process, exonucleolytic (GO:0000738)2.97086774
57reproduction (GO:0000003)2.93207100
58spermatid development (GO:0007286)2.91725742
59Golgi to endosome transport (GO:0006895)2.86321498
60cytochrome complex assembly (GO:0017004)2.85861421
61fusion of sperm to egg plasma membrane (GO:0007342)2.84075656
62protein O-linked glycosylation (GO:0006493)2.83930861
63double-strand break repair via nonhomologous end joining (GO:0006303)2.82849775
64non-recombinational repair (GO:0000726)2.82849775
65protein import into peroxisome matrix (GO:0016558)2.79245629
66renal tubule morphogenesis (GO:0061333)2.73715711
67histone H3-K9 methylation (GO:0051567)2.69860073
68auditory receptor cell stereocilium organization (GO:0060088)2.69375343
69single fertilization (GO:0007338)2.68104295
70cellular ketone body metabolic process (GO:0046950)2.67389738
71mast cell degranulation (GO:0043303)2.66575137
72mast cell activation involved in immune response (GO:0002279)2.66575137
73negative regulation of mast cell activation (GO:0033004)2.64581797
74histone H3-K4 methylation (GO:0051568)2.63963978
75cellular response to ethanol (GO:0071361)2.60648551
76glial cell proliferation (GO:0014009)2.59184494
77interleukin-6-mediated signaling pathway (GO:0070102)2.57682871
78positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.57113958
79maturation of 5.8S rRNA (GO:0000460)2.56314006
80mitochondrial DNA replication (GO:0006264)2.56076847
81histone H3-K4 trimethylation (GO:0080182)2.55361729
82cellular biogenic amine catabolic process (GO:0042402)2.54602057
83amine catabolic process (GO:0009310)2.54602057
84protein polyglutamylation (GO:0018095)2.53512943
85transcription from mitochondrial promoter (GO:0006390)2.50990603
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50822955
87regulation of hippo signaling (GO:0035330)2.50125261
88positive regulation of DNA repair (GO:0045739)2.49438649
89nicotinamide nucleotide biosynthetic process (GO:0019359)2.47416329
90pyridine nucleotide biosynthetic process (GO:0019363)2.47416329
91regulation of cilium movement (GO:0003352)2.47309975
92brain morphogenesis (GO:0048854)2.47222116
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46089862
94regulation of mitotic spindle checkpoint (GO:1903504)2.46089862
95fucosylation (GO:0036065)2.45992321
96ketone body metabolic process (GO:1902224)2.40846924
97adaptation of signaling pathway (GO:0023058)2.40398428
98indole-containing compound metabolic process (GO:0042430)2.39791060
99regulation of acrosome reaction (GO:0060046)2.38806415
100negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.38017043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.66676975
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.60716835
3ZNF274_21170338_ChIP-Seq_K562_Hela3.27470949
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.26089664
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.80271443
6ER_23166858_ChIP-Seq_MCF-7_Human2.67053144
7GBX2_23144817_ChIP-Seq_PC3_Human2.59537063
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47857244
9VDR_22108803_ChIP-Seq_LS180_Human2.43533097
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34705446
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.29347471
12IGF1R_20145208_ChIP-Seq_DFB_Human2.04908989
13DROSHA_22980978_ChIP-Seq_HELA_Human1.83675009
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82976919
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80197991
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76124625
17AR_21572438_ChIP-Seq_LNCaP_Human1.74918282
18GATA3_26560356_Chip-Seq_TH2_Human1.74166091
19BCAT_22108803_ChIP-Seq_LS180_Human1.71849434
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68578812
21FUS_26573619_Chip-Seq_HEK293_Human1.67648566
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67575028
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.66646824
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65484660
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.65309665
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64163332
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63363942
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.62605535
29CBP_20019798_ChIP-Seq_JUKART_Human1.61997232
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61997232
31RUNX_20019798_ChIP-Seq_JUKART_Human1.57421032
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.55122658
33ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48283474
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43730310
35TP53_22573176_ChIP-Seq_HFKS_Human1.43699347
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.43050239
37TCF4_23295773_ChIP-Seq_U87_Human1.40323664
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39973148
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34413782
40AR_25329375_ChIP-Seq_VCAP_Human1.31799876
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30450340
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30450340
43ERA_21632823_ChIP-Seq_H3396_Human1.29546089
44GATA3_27048872_Chip-Seq_THYMUS_Human1.28187712
45P300_19829295_ChIP-Seq_ESCs_Human1.28142483
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28114879
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.28103603
48STAT3_23295773_ChIP-Seq_U87_Human1.28041863
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26155774
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26004731
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24948309
52TCF4_22108803_ChIP-Seq_LS180_Human1.24857219
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24801560
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23859535
55CDX2_22108803_ChIP-Seq_LS180_Human1.22242566
56MYC_19829295_ChIP-Seq_ESCs_Human1.18999285
57NCOR_22424771_ChIP-Seq_293T_Human1.17281118
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16473780
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14952016
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14847023
61OCT4_20526341_ChIP-Seq_ESCs_Human1.11155743
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10895549
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.08152651
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08054340
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07983890
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.07444974
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06862873
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06092643
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05856273
70EWS_26573619_Chip-Seq_HEK293_Human1.05709748
71SCL_19346495_ChIP-Seq_HPC-7_Human1.05705811
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04910785
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.03651916
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.03139900
75HOXB7_26014856_ChIP-Seq_BT474_Human1.02950219
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01885652
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.01885652
78SMAD4_21799915_ChIP-Seq_A2780_Human1.01776130
79CEBPB_22108803_ChIP-Seq_LS180_Human1.00827330
80MYB_26560356_Chip-Seq_TH2_Human1.00250048
81GATA3_26560356_Chip-Seq_TH1_Human1.00032302
82ETV1_20927104_ChIP-Seq_GIST48_Human0.99555878
83AR_20517297_ChIP-Seq_VCAP_Human0.99491175
84RXR_22108803_ChIP-Seq_LS180_Human0.98937461
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.98508248
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97530933
87EZH2_22144423_ChIP-Seq_EOC_Human0.97473830
88SMRT_27268052_Chip-Seq_Bcells_Human0.97239595
89RAC3_21632823_ChIP-Seq_H3396_Human0.96440434
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95304653
91E2F1_20622854_ChIP-Seq_HELA_Human0.94797361
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.94205331
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93705839
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93344480
95TAF2_19829295_ChIP-Seq_ESCs_Human0.93318317
96IRF1_19129219_ChIP-ChIP_H3396_Human0.92975386
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92855631
98TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92605479
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92591344
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.92486110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000465_gastrointestinal_hemorrhage3.38058961
2MP0008004_abnormal_stomach_pH2.86087543
3MP0003195_calcinosis2.76030241
4MP0008058_abnormal_DNA_repair2.63763584
5MP0010094_abnormal_chromosome_stability2.61795851
6MP0005410_abnormal_fertilization2.57162070
7MP0004043_abnormal_pH_regulation2.48346410
8MP0003866_abnormal_defecation2.40508722
9MP0005551_abnormal_eye_electrophysiolog2.19759613
10MP0001485_abnormal_pinna_reflex1.96067502
11MP0008995_early_reproductive_senescence1.89231499
12MP0005220_abnormal_exocrine_pancreas1.87571179
13MP0008057_abnormal_DNA_replication1.84008980
14MP0006072_abnormal_retinal_apoptosis1.83762297
15MP0000427_abnormal_hair_cycle1.82221935
16MP0005310_abnormal_salivary_gland1.79955131
17MP0003786_premature_aging1.73467587
18MP0008875_abnormal_xenobiotic_pharmacok1.70891028
19MP0000538_abnormal_urinary_bladder1.70873109
20MP0005671_abnormal_response_to1.69110262
21MP0001835_abnormal_antigen_presentation1.68623654
22MP0004147_increased_porphyrin_level1.64130682
23MP0001666_abnormal_nutrient_absorption1.62899104
24MP0001765_abnormal_ion_homeostasis1.57090146
25MP0005253_abnormal_eye_physiology1.55051995
26MP0003763_abnormal_thymus_physiology1.53667107
27MP0008872_abnormal_physiological_respon1.52449470
28MP0002166_altered_tumor_susceptibility1.50599386
29MP0001984_abnormal_olfaction1.50471422
30MP0010307_abnormal_tumor_latency1.47895553
31MP0003806_abnormal_nucleotide_metabolis1.45156124
32MP0004145_abnormal_muscle_electrophysio1.39538676
33MP0010155_abnormal_intestine_physiology1.38969919
34MP0002138_abnormal_hepatobiliary_system1.36538700
35MP0003698_abnormal_male_reproductive1.36473145
36MP0001968_abnormal_touch/_nociception1.35222640
37MP0005645_abnormal_hypothalamus_physiol1.34350292
38MP0002735_abnormal_chemical_nociception1.33414615
39MP0003878_abnormal_ear_physiology1.33047536
40MP0005377_hearing/vestibular/ear_phenot1.33047536
41MP0000470_abnormal_stomach_morphology1.32556504
42MP0001929_abnormal_gametogenesis1.31794872
43MP0005646_abnormal_pituitary_gland1.29931815
44MP0001663_abnormal_digestive_system1.22730722
45MP0001664_abnormal_digestion1.21569008
46MP0001800_abnormal_humoral_immune1.20668403
47MP0008877_abnormal_DNA_methylation1.20538888
48MP0001501_abnormal_sleep_pattern1.20172129
49MP0005448_abnormal_energy_balance1.14785277
50MP0003718_maternal_effect1.14014662
51MP0002928_abnormal_bile_duct1.13208445
52MP0004742_abnormal_vestibular_system1.11746868
53MP0002006_tumorigenesis1.09227343
54MP0005083_abnormal_biliary_tract1.08023788
55MP0010386_abnormal_urinary_bladder1.07413181
56MP0005167_abnormal_blood-brain_barrier1.06551521
57MP0003693_abnormal_embryo_hatching1.02603385
58MP0001873_stomach_inflammation1.01722607
59MP0002822_catalepsy0.99821990
60MP0002396_abnormal_hematopoietic_system0.99694307
61MP0001986_abnormal_taste_sensitivity0.98603036
62MP0004924_abnormal_behavior0.97711318
63MP0005386_behavior/neurological_phenoty0.97711318
64MP0002148_abnormal_hypersensitivity_rea0.97256022
65MP0009046_muscle_twitch0.96543922
66MP0002160_abnormal_reproductive_system0.94997172
67MP0002229_neurodegeneration0.94621204
68MP0004264_abnormal_extraembryonic_tissu0.92798060
69MP0005387_immune_system_phenotype0.92754241
70MP0001790_abnormal_immune_system0.92754241
71MP0000703_abnormal_thymus_morphology0.91380994
72MP0002210_abnormal_sex_determination0.90796867
73MP0001545_abnormal_hematopoietic_system0.90320094
74MP0005397_hematopoietic_system_phenotyp0.90320094
75MP0000383_abnormal_hair_follicle0.89650801
76MP0008961_abnormal_basal_metabolism0.89031815
77MP0005266_abnormal_metabolism0.88822531
78MP0005389_reproductive_system_phenotype0.88139041
79MP0002733_abnormal_thermal_nociception0.87528871
80MP0001270_distended_abdomen0.86786065
81MP0002398_abnormal_bone_marrow0.86595948
82MP0002452_abnormal_antigen_presenting0.84473613
83MP0003252_abnormal_bile_duct0.83937776
84MP0002876_abnormal_thyroid_physiology0.83519803
85MP0000372_irregular_coat_pigmentation0.80978248
86MP0002420_abnormal_adaptive_immunity0.80295507
87MP0002693_abnormal_pancreas_physiology0.80072569
88MP0001819_abnormal_immune_cell0.79745893
89MP0001905_abnormal_dopamine_level0.79585495
90MP0005381_digestive/alimentary_phenotyp0.79575688
91MP0002837_dystrophic_cardiac_calcinosis0.79250082
92MP0002722_abnormal_immune_system0.76788871
93MP0004808_abnormal_hematopoietic_stem0.76538019
94MP0005395_other_phenotype0.75345488
95MP0000689_abnormal_spleen_morphology0.75271924
96MP0001764_abnormal_homeostasis0.75108345
97MP0001502_abnormal_circadian_rhythm0.73908810
98MP0001963_abnormal_hearing_physiology0.73807331
99MP0002723_abnormal_immune_serum0.73797484
100MP0000230_abnormal_systemic_arterial0.73274308

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.41847518
2Abnormality of the renal cortex (HP:0011035)3.20809897
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17934343
4Impulsivity (HP:0100710)3.10124878
5Cerebellar dysplasia (HP:0007033)2.92799566
6Tubulointerstitial nephritis (HP:0001970)2.88814024
7Panhypogammaglobulinemia (HP:0003139)2.88610775
8Aplasia/Hypoplasia of the uvula (HP:0010293)2.84130167
9Hyperventilation (HP:0002883)2.83968317
10Chromsome breakage (HP:0040012)2.81818616
11Attenuation of retinal blood vessels (HP:0007843)2.80848810
12Enlarged epiphyses (HP:0010580)2.80436187
13Thyroiditis (HP:0100646)2.78985902
14Abnormality of the renal collecting system (HP:0004742)2.70938052
15Stomach cancer (HP:0012126)2.70432887
16Abnormality of the renal medulla (HP:0100957)2.67160350
17Renal cortical cysts (HP:0000803)2.66877611
18Congenital sensorineural hearing impairment (HP:0008527)2.64398769
19Congenital, generalized hypertrichosis (HP:0004540)2.62412677
20Hyperkalemia (HP:0002153)2.62290945
21Abnormality of chloride homeostasis (HP:0011422)2.60793682
22Duplicated collecting system (HP:0000081)2.60439397
23Palpebral edema (HP:0100540)2.55611490
24Type II lissencephaly (HP:0007260)2.55375530
25Abnormality of B cell number (HP:0010975)2.55278392
26Abnormality of the preputium (HP:0100587)2.49701227
27Cystic liver disease (HP:0006706)2.48149590
28Ectopic kidney (HP:0000086)2.45327016
29Adactyly (HP:0009776)2.45301207
30Pancreatic cysts (HP:0001737)2.42918750
31Severe combined immunodeficiency (HP:0004430)2.40892842
32Abnormality of the columella (HP:0009929)2.40419462
33Abnormal rod and cone electroretinograms (HP:0008323)2.37310963
34Autoimmune thrombocytopenia (HP:0001973)2.32745277
35Nephronophthisis (HP:0000090)2.32309792
36Hypergonadotropic hypogonadism (HP:0000815)2.31641000
37Bony spicule pigmentary retinopathy (HP:0007737)2.31577310
38Pancreatic fibrosis (HP:0100732)2.30598808
39Spinal muscular atrophy (HP:0007269)2.29282980
40Clubbing of toes (HP:0100760)2.26089095
41Stomatitis (HP:0010280)2.25518829
42Autoimmune hemolytic anemia (HP:0001890)2.23418456
43Gaze-evoked nystagmus (HP:0000640)2.18980802
44Abnormality of the ileum (HP:0001549)2.18662093
45Abnormality of chromosome stability (HP:0003220)2.17288227
46Abnormal biliary tract physiology (HP:0012439)2.16931242
47Bile duct proliferation (HP:0001408)2.16931242
48Molar tooth sign on MRI (HP:0002419)2.15446805
49Abnormality of midbrain morphology (HP:0002418)2.15446805
50Abnormality of the vitamin B12 metabolism (HP:0004341)2.14283106
51Glioma (HP:0009733)2.13806970
52Abnormality of vitamin B metabolism (HP:0004340)2.10830976
53Severe visual impairment (HP:0001141)2.08640420
54Pendular nystagmus (HP:0012043)2.06584818
55Tubulointerstitial abnormality (HP:0001969)2.04688835
56Keratoconus (HP:0000563)2.02494194
57Increased corneal curvature (HP:0100692)2.02494194
58IgM deficiency (HP:0002850)2.01741883
59Abnormality of the nasal septum (HP:0000419)2.01433255
60Tongue fasciculations (HP:0001308)2.00808952
61Abnormality of the carotid arteries (HP:0005344)1.98686657
62Meckel diverticulum (HP:0002245)1.97981132
63Tubular atrophy (HP:0000092)1.96863550
64Congenital hepatic fibrosis (HP:0002612)1.96336727
65Broad-based gait (HP:0002136)1.95648606
66Abnormal delayed hypersensitivity skin test (HP:0002963)1.95459684
67Methylmalonic acidemia (HP:0002912)1.95296714
68Abnormality of dental color (HP:0011073)1.93854781
69Delayed CNS myelination (HP:0002188)1.93680103
70Tented upper lip vermilion (HP:0010804)1.92598857
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91530501
72Abnormal protein N-linked glycosylation (HP:0012347)1.91530501
73Abnormal protein glycosylation (HP:0012346)1.91530501
74Abnormal glycosylation (HP:0012345)1.91530501
75Prominent nose (HP:0000448)1.91126382
76Hypoplasia of the pons (HP:0012110)1.90747696
77Abnormal hair whorl (HP:0010721)1.90549181
78Fair hair (HP:0002286)1.90151046
79Bulbous nose (HP:0000414)1.90024532
80Neurodegeneration (HP:0002180)1.89977570
81Abnormality of dentin (HP:0010299)1.89483665
82Volvulus (HP:0002580)1.88820608
83Neoplasm of the adrenal cortex (HP:0100641)1.88432405
84Abnormality of lateral ventricle (HP:0030047)1.86718891
85Absent speech (HP:0001344)1.86543933
86True hermaphroditism (HP:0010459)1.85854153
87Hypophosphatemic rickets (HP:0004912)1.85668960
88Congenital stationary night blindness (HP:0007642)1.84878847
89Eosinophilia (HP:0001880)1.84026820
90Ependymoma (HP:0002888)1.83699780
91Tubulointerstitial fibrosis (HP:0005576)1.83408197
92Thyroid-stimulating hormone excess (HP:0002925)1.82887392
93Protruding tongue (HP:0010808)1.82687403
94Pili torti (HP:0003777)1.82538836
95Sloping forehead (HP:0000340)1.81121495
96Hypoproteinemia (HP:0003075)1.80775683
97Clumsiness (HP:0002312)1.79972075
98Methylmalonic aciduria (HP:0012120)1.77348078
99Villous atrophy (HP:0011473)1.77172120
100Abnormality of small intestinal villus morphology (HP:0011472)1.77172120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.03358923
2WNK44.85129572
3MST1R3.88219523
4BMPR1B3.54961959
5NME12.95855969
6INSRR2.72727113
7MET2.48067352
8ZAK2.37423088
9STK392.03880431
10CDK121.91833209
11PINK11.79461563
12ACVR1B1.73983005
13MAP4K21.73562188
14PLK41.69868971
15WNK11.68133810
16NUAK11.55886257
17FGFR21.45730894
18CAMK1D1.36038401
19OXSR11.30852889
20GRK11.27014748
21STK381.26315597
22MAPK131.25097109
23ADRBK21.24348714
24AKT31.22296000
25MAP2K61.22243092
26PIK3CA1.19914975
27BLK1.18279568
28TEC1.11165250
29TAOK31.10553347
30TNIK1.06745159
31MAP4K11.05796954
32TXK1.05016422
33KIT1.02955745
34STK38L0.99217075
35CAMK1G0.96760038
36CAMKK20.94925342
37NEK20.93057516
38CASK0.92815646
39ATR0.90080937
40WNK30.89292754
41TGFBR10.83928054
42TNK20.80655397
43MUSK0.80548201
44EPHA30.78565295
45PDK20.77413305
46CSNK1A1L0.77128681
47SYK0.75707272
48MKNK20.73521345
49CSNK1G30.72058492
50CDK80.69498503
51CDK30.69343117
52MST40.67807701
53CSNK1G10.67606373
54NLK0.67438861
55ERBB20.66641746
56SIK20.66251074
57PTK2B0.66237491
58PHKG10.64708543
59PHKG20.64708543
60CSF1R0.64438971
61DAPK20.64088010
62PLK20.62823043
63MKNK10.61415225
64ITK0.60589757
65BRSK20.59920807
66BRD40.58490424
67CHUK0.58431095
68TLK10.58349082
69OBSCN0.56398946
70MAPK110.55533510
71PRKAA20.54353671
72GRK70.52258290
73PDK10.50298300
74IKBKB0.50217422
75MAPK150.49471669
76PAK30.48215532
77MARK30.46036050
78ATM0.45768891
79LYN0.45310810
80BTK0.45073994
81LCK0.42609283
82EIF2AK30.39392308
83HIPK20.39154365
84PKN10.38693043
85RPS6KA50.38637763
86FGFR30.38527129
87CHEK10.37703808
88PRKCQ0.37466163
89ADRBK10.34364873
90FER0.33425760
91MAPK10.32825053
92CSNK1A10.32582068
93CSNK1G20.31596402
94PRKCE0.31098780
95PRKAA10.30468268
96PBK0.29886281
97HCK0.29841042
98FES0.29667066
99MAP3K40.29223510
100TRPM70.27759645

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.27409124
2Fanconi anemia pathway_Homo sapiens_hsa034602.92177174
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.71951171
4* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.60099750
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40002635
6Asthma_Homo sapiens_hsa053102.36919969
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30407309
8Olfactory transduction_Homo sapiens_hsa047402.26500175
9RNA polymerase_Homo sapiens_hsa030202.21562680
10Homologous recombination_Homo sapiens_hsa034402.17571877
11Butanoate metabolism_Homo sapiens_hsa006502.16516112
12Primary immunodeficiency_Homo sapiens_hsa053402.09945143
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.05333335
14* Oocyte meiosis_Homo sapiens_hsa041142.01205463
15Phototransduction_Homo sapiens_hsa047442.00712829
16Lysine degradation_Homo sapiens_hsa003101.81676597
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78117863
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68819389
19Allograft rejection_Homo sapiens_hsa053301.65601177
20Nitrogen metabolism_Homo sapiens_hsa009101.58992701
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56697895
22Autoimmune thyroid disease_Homo sapiens_hsa053201.53888962
23Linoleic acid metabolism_Homo sapiens_hsa005911.49046072
24ABC transporters_Homo sapiens_hsa020101.45053397
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.36456470
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31707487
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30587386
28Graft-versus-host disease_Homo sapiens_hsa053321.30344112
29Salivary secretion_Homo sapiens_hsa049701.29423161
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27149503
31Type I diabetes mellitus_Homo sapiens_hsa049401.21479782
32Tryptophan metabolism_Homo sapiens_hsa003801.18226410
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15628889
34Ether lipid metabolism_Homo sapiens_hsa005651.14041815
35Taste transduction_Homo sapiens_hsa047421.12113844
36Basal transcription factors_Homo sapiens_hsa030221.10930288
37Peroxisome_Homo sapiens_hsa041461.05788212
38Propanoate metabolism_Homo sapiens_hsa006401.04145007
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99710538
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99489035
41Base excision repair_Homo sapiens_hsa034100.97127772
42RNA degradation_Homo sapiens_hsa030180.95681812
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.94317532
44Non-homologous end-joining_Homo sapiens_hsa034500.93718133
45Purine metabolism_Homo sapiens_hsa002300.90394029
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81673568
47Hematopoietic cell lineage_Homo sapiens_hsa046400.78979743
48Antigen processing and presentation_Homo sapiens_hsa046120.78241415
49Protein digestion and absorption_Homo sapiens_hsa049740.76911963
50Pyrimidine metabolism_Homo sapiens_hsa002400.76494832
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76226720
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.76056753
53Arachidonic acid metabolism_Homo sapiens_hsa005900.72221133
54Chemical carcinogenesis_Homo sapiens_hsa052040.70245824
55RNA transport_Homo sapiens_hsa030130.69730964
56Fatty acid biosynthesis_Homo sapiens_hsa000610.69723330
57Calcium signaling pathway_Homo sapiens_hsa040200.69425829
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.69406915
59Staphylococcus aureus infection_Homo sapiens_hsa051500.68107158
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66993792
61Gastric acid secretion_Homo sapiens_hsa049710.66696941
62Other glycan degradation_Homo sapiens_hsa005110.65336652
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64783464
64Insulin secretion_Homo sapiens_hsa049110.64036522
65One carbon pool by folate_Homo sapiens_hsa006700.62625421
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61486629
67Renin secretion_Homo sapiens_hsa049240.57271318
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57200276
69Dorso-ventral axis formation_Homo sapiens_hsa043200.52948123
70Pancreatic secretion_Homo sapiens_hsa049720.52859094
71Fatty acid metabolism_Homo sapiens_hsa012120.52809306
72DNA replication_Homo sapiens_hsa030300.50399654
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.48906490
74Glycerolipid metabolism_Homo sapiens_hsa005610.48516241
75Platelet activation_Homo sapiens_hsa046110.48425529
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.46630890
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45956117
78African trypanosomiasis_Homo sapiens_hsa051430.45899273
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45793057
80N-Glycan biosynthesis_Homo sapiens_hsa005100.45641874
81Ovarian steroidogenesis_Homo sapiens_hsa049130.44984416
82Sulfur relay system_Homo sapiens_hsa041220.43781624
83Herpes simplex infection_Homo sapiens_hsa051680.42354513
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42263654
85Proteasome_Homo sapiens_hsa030500.40295630
86Long-term depression_Homo sapiens_hsa047300.37862746
87Systemic lupus erythematosus_Homo sapiens_hsa053220.36974196
88Metabolic pathways_Homo sapiens_hsa011000.33610344
89cAMP signaling pathway_Homo sapiens_hsa040240.32130134
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.31010972
91Retinol metabolism_Homo sapiens_hsa008300.29740086
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29477486
93Protein export_Homo sapiens_hsa030600.29313145
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25496134
95Fatty acid degradation_Homo sapiens_hsa000710.25147886
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22663745
97Glutamatergic synapse_Homo sapiens_hsa047240.22294649
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21912665
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21522068
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21311244

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