SPDYE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to Golgi (GO:0072600)6.63189161
2protein targeting to Golgi (GO:0000042)6.16916949
3retrograde transport, vesicle recycling within Golgi (GO:0000301)5.90439790
4maintenance of gastrointestinal epithelium (GO:0030277)4.72865745
5protein localization to Golgi apparatus (GO:0034067)4.70466348
6DNA double-strand break processing (GO:0000729)4.25022422
7fucose catabolic process (GO:0019317)4.02448640
8L-fucose metabolic process (GO:0042354)4.02448640
9L-fucose catabolic process (GO:0042355)4.02448640
10intra-Golgi vesicle-mediated transport (GO:0006891)3.86023034
11positive regulation of granulocyte differentiation (GO:0030854)3.78582435
12histone H3-K9 methylation (GO:0051567)3.78087515
13histone H3-K4 trimethylation (GO:0080182)3.53854795
14photoreceptor cell maintenance (GO:0045494)3.51037312
15epithelial structure maintenance (GO:0010669)3.49740808
16histone H3-K9 modification (GO:0061647)3.47636049
17mannosylation (GO:0097502)3.45438107
18rRNA catabolic process (GO:0016075)3.41680291
19regulation of glucokinase activity (GO:0033131)3.28612881
20regulation of hexokinase activity (GO:1903299)3.28612881
21regulation of ARF GTPase activity (GO:0032312)3.21101318
22axoneme assembly (GO:0035082)3.16519163
23multicellular organism reproduction (GO:0032504)3.16211588
24protein polyglutamylation (GO:0018095)3.15743383
25sperm motility (GO:0030317)3.11203905
26histone H2A acetylation (GO:0043968)3.07227715
27positive regulation of mRNA catabolic process (GO:0061014)3.05963052
28cellular ketone body metabolic process (GO:0046950)3.04819888
29RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01159237
30cilium or flagellum-dependent cell motility (GO:0001539)3.00116286
31peptidyl-lysine trimethylation (GO:0018023)2.99115338
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93452367
33negative regulation of translation, ncRNA-mediated (GO:0040033)2.93452367
34regulation of translation, ncRNA-mediated (GO:0045974)2.93452367
35regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.83109003
36positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.83109003
37histone lysine methylation (GO:0034968)2.81678972
38tryptophan metabolic process (GO:0006568)2.78589920
39nephron tubule morphogenesis (GO:0072078)2.78124657
40nephron epithelium morphogenesis (GO:0072088)2.78124657
41acrosome reaction (GO:0007340)2.77094296
42regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.76106723
43positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.76106723
44RNA destabilization (GO:0050779)2.73961615
45positive regulation of organelle assembly (GO:1902117)2.71131212
46regulation of mRNA catabolic process (GO:0061013)2.71073669
47histone H3-K4 methylation (GO:0051568)2.67800461
48growth hormone receptor signaling pathway (GO:0060396)2.67780301
49regulation of cilium movement (GO:0003352)2.66257304
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66161486
51protein K11-linked deubiquitination (GO:0035871)2.66148653
52negative regulation of cAMP-mediated signaling (GO:0043951)2.64782949
53ketone body metabolic process (GO:1902224)2.63802851
54cytoplasmic mRNA processing body assembly (GO:0033962)2.62766322
55brain morphogenesis (GO:0048854)2.62430044
56preassembly of GPI anchor in ER membrane (GO:0016254)2.59916785
57replication fork processing (GO:0031297)2.58668275
58methionine biosynthetic process (GO:0009086)2.54721443
59detection of light stimulus involved in visual perception (GO:0050908)2.54339665
60detection of light stimulus involved in sensory perception (GO:0050962)2.54339665
61histone mRNA catabolic process (GO:0071044)2.54135254
62phosphatidylethanolamine metabolic process (GO:0046337)2.54048291
63positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.51301982
64auditory receptor cell stereocilium organization (GO:0060088)2.49553932
65peptidyl-lysine methylation (GO:0018022)2.48077601
66O-glycan processing (GO:0016266)2.46421421
67indolalkylamine metabolic process (GO:0006586)2.44854114
68phosphatidylethanolamine biosynthetic process (GO:0006646)2.44641179
69N-terminal protein amino acid acetylation (GO:0006474)2.44568093
70protein K63-linked deubiquitination (GO:0070536)2.44264864
71response to pheromone (GO:0019236)2.42871239
72rRNA methylation (GO:0031167)2.42659099
73double-strand break repair via homologous recombination (GO:0000724)2.42488194
74positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.41794761
75intra-S DNA damage checkpoint (GO:0031573)2.40114691
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39949845
77regulation of MHC class I biosynthetic process (GO:0045343)2.39365401
78positive regulation of CREB transcription factor activity (GO:0032793)2.38099845
79recombinational repair (GO:0000725)2.37039130
80Golgi to endosome transport (GO:0006895)2.36598316
81centriole replication (GO:0007099)2.34539455
82organic cation transport (GO:0015695)2.34476632
83microtubule nucleation (GO:0007020)2.33866788
84negative T cell selection (GO:0043383)2.33226967
85chromatin silencing (GO:0006342)2.32757800
86cellular response to growth hormone stimulus (GO:0071378)2.31565118
87male meiosis (GO:0007140)2.31238776
88mismatch repair (GO:0006298)2.30001494
89protein K48-linked deubiquitination (GO:0071108)2.29280741
90positive regulation of mRNA 3-end processing (GO:0031442)2.28978209
91DNA catabolic process, exonucleolytic (GO:0000738)2.28658727
92L-methionine biosynthetic process (GO:0071265)2.28243933
93amino acid salvage (GO:0043102)2.28243933
94L-methionine salvage (GO:0071267)2.28243933
95ubiquinone biosynthetic process (GO:0006744)2.27745085
96protein O-linked glycosylation (GO:0006493)2.27646292
97positive regulation of mRNA metabolic process (GO:1903313)2.27550698
98spermatid development (GO:0007286)2.26309325
99DNA alkylation (GO:0006305)2.23370870
100DNA methylation (GO:0006306)2.23370870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.31651151
2ZNF274_21170338_ChIP-Seq_K562_Hela3.13066213
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.98856798
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70282025
5GBX2_23144817_ChIP-Seq_PC3_Human2.54883320
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.54224816
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42087024
8* ER_23166858_ChIP-Seq_MCF-7_Human2.36529137
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19827662
10IGF1R_20145208_ChIP-Seq_DFB_Human2.12026075
11VDR_22108803_ChIP-Seq_LS180_Human2.06324755
12DROSHA_22980978_ChIP-Seq_HELA_Human1.98006718
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92266930
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90018093
15AR_21572438_ChIP-Seq_LNCaP_Human1.86755075
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83380259
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.82520007
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76240390
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75967217
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.75581359
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73093452
22CBP_20019798_ChIP-Seq_JUKART_Human1.73093452
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.71031246
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68641263
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68398251
26STAT3_23295773_ChIP-Seq_U87_Human1.62591770
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60430718
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.60284794
29RUNX_20019798_ChIP-Seq_JUKART_Human1.60164989
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59434604
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.55034473
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.53888124
33GATA3_26560356_Chip-Seq_TH2_Human1.53765367
34TCF4_23295773_ChIP-Seq_U87_Human1.51351609
35CIITA_25753668_ChIP-Seq_RAJI_Human1.49040322
36BCAT_22108803_ChIP-Seq_LS180_Human1.47813374
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47351845
38TP53_22573176_ChIP-Seq_HFKS_Human1.38607713
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38166944
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38113645
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36384747
42SMAD4_21799915_ChIP-Seq_A2780_Human1.35842136
43FUS_26573619_Chip-Seq_HEK293_Human1.35692777
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33696432
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32706913
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32706913
47GATA3_27048872_Chip-Seq_THYMUS_Human1.32117947
48EWS_26573619_Chip-Seq_HEK293_Human1.30928887
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.30260090
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29098909
51TCF4_22108803_ChIP-Seq_LS180_Human1.28916033
52MYB_26560356_Chip-Seq_TH2_Human1.28730886
53AR_25329375_ChIP-Seq_VCAP_Human1.27325088
54P300_19829295_ChIP-Seq_ESCs_Human1.24502059
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17448720
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14821375
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14537619
58RUNX2_22187159_ChIP-Seq_PCA_Human1.14273828
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14122236
60OCT4_20526341_ChIP-Seq_ESCs_Human1.13642508
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12934168
62SMRT_27268052_Chip-Seq_Bcells_Human1.12678253
63ERA_21632823_ChIP-Seq_H3396_Human1.12207590
64TAF15_26573619_Chip-Seq_HEK293_Human1.11800599
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10870816
66CDX2_22108803_ChIP-Seq_LS180_Human1.10617870
67HOXB7_26014856_ChIP-Seq_BT474_Human1.10280068
68AHR_22903824_ChIP-Seq_MCF-7_Human1.10266220
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10070128
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.09925224
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09786256
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.09162512
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09157069
74SCL_19346495_ChIP-Seq_HPC-7_Human1.08664608
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08183794
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07986208
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07794125
78IRF1_19129219_ChIP-ChIP_H3396_Human1.07575582
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06820759
80GATA1_22025678_ChIP-Seq_K562_Human1.01955401
81GATA3_26560356_Chip-Seq_TH1_Human1.01900215
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.01771974
83EZH2_22144423_ChIP-Seq_EOC_Human1.01712980
84VDR_23849224_ChIP-Seq_CD4+_Human1.01315934
85AR_20517297_ChIP-Seq_VCAP_Human1.01144009
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.00489463
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00177921
88MYC_19829295_ChIP-Seq_ESCs_Human1.00005942
89TBL1_22424771_ChIP-Seq_293T_Human0.99869783
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.99379114
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.99051379
92MYB_26560356_Chip-Seq_TH1_Human0.98931064
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98705127
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97398677
95ETV1_20927104_ChIP-Seq_GIST48_Human0.97333807
96NCOR_22424771_ChIP-Seq_293T_Human0.97114392
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.95334928
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95214004
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95194435
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93875668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation2.66196610
2MP0008057_abnormal_DNA_replication2.65341218
3MP0002138_abnormal_hepatobiliary_system2.45284198
4MP0005551_abnormal_eye_electrophysiolog2.24126028
5MP0003195_calcinosis2.21598118
6MP0000465_gastrointestinal_hemorrhage2.16833447
7MP0008995_early_reproductive_senescence2.14965963
8MP0001968_abnormal_touch/_nociception2.05502614
9MP0001984_abnormal_olfaction2.02105750
10MP0005645_abnormal_hypothalamus_physiol1.99034206
11MP0003763_abnormal_thymus_physiology1.93811161
12MP0008058_abnormal_DNA_repair1.92295748
13MP0008877_abnormal_DNA_methylation1.92286956
14MP0005410_abnormal_fertilization1.89267622
15MP0005253_abnormal_eye_physiology1.89101057
16MP0000569_abnormal_digit_pigmentation1.82467589
17MP0003866_abnormal_defecation1.81937282
18MP0001501_abnormal_sleep_pattern1.74078412
19MP0001986_abnormal_taste_sensitivity1.73105073
20MP0003786_premature_aging1.68502403
21MP0000427_abnormal_hair_cycle1.63971377
22MP0005646_abnormal_pituitary_gland1.63877444
23MP0010094_abnormal_chromosome_stability1.61348032
24MP0003045_fibrosis1.57257455
25MP0006072_abnormal_retinal_apoptosis1.57240453
26MP0002102_abnormal_ear_morphology1.56218555
27MP0001485_abnormal_pinna_reflex1.54369644
28MP0005310_abnormal_salivary_gland1.52996794
29MP0000383_abnormal_hair_follicle1.51664751
30MP0002822_catalepsy1.45843609
31MP0008004_abnormal_stomach_pH1.43637233
32MP0008961_abnormal_basal_metabolism1.43297158
33MP0003787_abnormal_imprinting1.43063034
34MP0003698_abnormal_male_reproductive1.32337190
35MP0001929_abnormal_gametogenesis1.30666160
36MP0002638_abnormal_pupillary_reflex1.29569723
37MP0005671_abnormal_response_to1.26625967
38MP0001835_abnormal_antigen_presentation1.25823193
39MP0002736_abnormal_nociception_after1.24024392
40MP0005167_abnormal_blood-brain_barrier1.23900291
41MP0002166_altered_tumor_susceptibility1.22742489
42MP0005083_abnormal_biliary_tract1.21330835
43MP0001800_abnormal_humoral_immune1.20176163
44MP0009278_abnormal_bone_marrow1.19934303
45MP0001270_distended_abdomen1.19557173
46MP0003646_muscle_fatigue1.17995783
47MP0003878_abnormal_ear_physiology1.16359193
48MP0005377_hearing/vestibular/ear_phenot1.16359193
49MP0000538_abnormal_urinary_bladder1.11855123
50MP0008872_abnormal_physiological_respon1.10220245
51MP0005220_abnormal_exocrine_pancreas1.09877439
52MP0009115_abnormal_fat_cell1.08873679
53MP0004264_abnormal_extraembryonic_tissu1.08583073
54MP0004145_abnormal_muscle_electrophysio1.08149700
55MP0010307_abnormal_tumor_latency1.03230607
56MP0000013_abnormal_adipose_tissue0.99610022
57MP0000470_abnormal_stomach_morphology0.99438201
58MP0002735_abnormal_chemical_nociception0.98855073
59MP0003943_abnormal_hepatobiliary_system0.95758919
60MP0000703_abnormal_thymus_morphology0.95163548
61MP0005266_abnormal_metabolism0.94608041
62MP0002168_other_aberrant_phenotype0.93407954
63MP0001765_abnormal_ion_homeostasis0.92678133
64MP0010155_abnormal_intestine_physiology0.92669687
65MP0002970_abnormal_white_adipose0.91283403
66MP0003172_abnormal_lysosome_physiology0.90868305
67MP0005397_hematopoietic_system_phenotyp0.89799793
68MP0001545_abnormal_hematopoietic_system0.89799793
69MP0002751_abnormal_autonomic_nervous0.88589083
70MP0002398_abnormal_bone_marrow0.86412154
71MP0004924_abnormal_behavior0.86226127
72MP0005386_behavior/neurological_phenoty0.86226127
73MP0002067_abnormal_sensory_capabilities0.86084772
74MP0002210_abnormal_sex_determination0.85836009
75MP0002229_neurodegeneration0.85454675
76MP0002928_abnormal_bile_duct0.85149631
77MP0004147_increased_porphyrin_level0.83021831
78MP0002876_abnormal_thyroid_physiology0.82928269
79MP0003718_maternal_effect0.82203521
80MP0001502_abnormal_circadian_rhythm0.81998840
81MP0001486_abnormal_startle_reflex0.81831083
82MP0002127_abnormal_cardiovascular_syste0.80634578
83MP0001666_abnormal_nutrient_absorption0.80461504
84MP0001664_abnormal_digestion0.80446417
85MP0000372_irregular_coat_pigmentation0.79070046
86MP0005448_abnormal_energy_balance0.78996157
87MP0002420_abnormal_adaptive_immunity0.78018655
88MP0005395_other_phenotype0.77800529
89MP0009046_muscle_twitch0.76605799
90MP0001819_abnormal_immune_cell0.75497028
91MP0002722_abnormal_immune_system0.75060349
92MP0002723_abnormal_immune_serum0.73784545
93MP0000230_abnormal_systemic_arterial0.73642488
94MP0002452_abnormal_antigen_presenting0.72888318
95MP0001764_abnormal_homeostasis0.71315333
96MP0010386_abnormal_urinary_bladder0.71089798
97MP0000716_abnormal_immune_system0.70665098
98MP0005076_abnormal_cell_differentiation0.69862316
99MP0005075_abnormal_melanosome_morpholog0.67920916
100MP0000689_abnormal_spleen_morphology0.66522181

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)4.60219462
2Abnormality of the fingertips (HP:0001211)4.00080382
3Hyperkalemia (HP:0002153)3.79783692
4Genetic anticipation (HP:0003743)3.48397223
5Hyperventilation (HP:0002883)3.36994130
6Abnormality of the renal cortex (HP:0011035)3.22943023
7Progressive cerebellar ataxia (HP:0002073)3.05189335
8Severe combined immunodeficiency (HP:0004430)2.97763559
9Fair hair (HP:0002286)2.90989515
10Panhypogammaglobulinemia (HP:0003139)2.90700015
11Ectopic kidney (HP:0000086)2.88275256
12Neonatal respiratory distress (HP:0002643)2.87871968
13Thyroiditis (HP:0100646)2.79685416
14Gaze-evoked nystagmus (HP:0000640)2.77253114
15Abnormality of the renal medulla (HP:0100957)2.74215730
16Clubbing of toes (HP:0100760)2.70294629
17Renal cortical cysts (HP:0000803)2.66258225
18Pancreatic cysts (HP:0001737)2.65546152
19Broad-based gait (HP:0002136)2.63977672
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62414341
21Absent speech (HP:0001344)2.59458695
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.58838516
23Duplicated collecting system (HP:0000081)2.53976885
24Attenuation of retinal blood vessels (HP:0007843)2.51635480
25Abnormal hair whorl (HP:0010721)2.47314627
26Cerebellar dysplasia (HP:0007033)2.46045750
27Clumsiness (HP:0002312)2.45715982
28Prominent nose (HP:0000448)2.43776232
29Abnormal biliary tract physiology (HP:0012439)2.43664025
30Bile duct proliferation (HP:0001408)2.43664025
31Chronic hepatic failure (HP:0100626)2.41009526
32Congenital stationary night blindness (HP:0007642)2.39898752
33Abnormality of the parathyroid morphology (HP:0011766)2.39478411
34Impulsivity (HP:0100710)2.38179198
35Nephronophthisis (HP:0000090)2.33093541
36Chromsome breakage (HP:0040012)2.32463721
37Cystic liver disease (HP:0006706)2.31692337
38Widely spaced teeth (HP:0000687)2.29140176
39Progressive inability to walk (HP:0002505)2.28487882
40Abnormality of the nasal septum (HP:0000419)2.28273859
41Abnormality of chloride homeostasis (HP:0011422)2.25751979
42Abnormality of the preputium (HP:0100587)2.25358946
43Generalized hypopigmentation of hair (HP:0011358)2.24907444
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.24651703
45Pustule (HP:0200039)2.24440345
46Abnormality of the ileum (HP:0001549)2.22076631
47Type II lissencephaly (HP:0007260)2.21402236
48Abnormality of the astrocytes (HP:0100707)2.20526656
49Astrocytoma (HP:0009592)2.20526656
50Pancreatic fibrosis (HP:0100732)2.19338210
51Spinal muscular atrophy (HP:0007269)2.16451395
52Abnormality of the columella (HP:0009929)2.16415869
53Hypoplasia of the thymus (HP:0000778)2.13334659
54Abnormality of the renal collecting system (HP:0004742)2.13104154
55Ependymoma (HP:0002888)2.11362479
56Tubulointerstitial abnormality (HP:0001969)2.10629183
57Abnormality of eosinophils (HP:0001879)2.10365762
58Abnormality of midbrain morphology (HP:0002418)2.09154532
59Molar tooth sign on MRI (HP:0002419)2.09154532
60Tubular atrophy (HP:0000092)2.07382666
61Meckel diverticulum (HP:0002245)2.05684917
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05464319
63Abnormal protein N-linked glycosylation (HP:0012347)2.05464319
64Abnormal protein glycosylation (HP:0012346)2.05464319
65Abnormal glycosylation (HP:0012345)2.05464319
66Hypoproteinemia (HP:0003075)2.04689191
67Abnormality of DNA repair (HP:0003254)2.04300846
68Eosinophilia (HP:0001880)2.02556971
69True hermaphroditism (HP:0010459)2.02010289
70Combined immunodeficiency (HP:0005387)2.01192529
71Inability to walk (HP:0002540)2.00950448
72Abnormality of chromosome stability (HP:0003220)2.00124583
73Medial flaring of the eyebrow (HP:0010747)2.00013822
74Progressive microcephaly (HP:0000253)1.99061129
75Glioma (HP:0009733)1.96975207
76Enlarged epiphyses (HP:0010580)1.94532403
77Granulocytopenia (HP:0001913)1.93949332
78Stomach cancer (HP:0012126)1.92676254
79Sloping forehead (HP:0000340)1.90614591
80Chronic diarrhea (HP:0002028)1.90286154
81Chronic mucocutaneous candidiasis (HP:0002728)1.89590125
82Recurrent cutaneous fungal infections (HP:0011370)1.89590125
83Truncal obesity (HP:0001956)1.88832139
84Abnormality of lateral ventricle (HP:0030047)1.88788203
85Inflammation of the large intestine (HP:0002037)1.88078452
86Abnormality of the carotid arteries (HP:0005344)1.87662532
87Facial diplegia (HP:0001349)1.87526820
88Abnormality of T cell physiology (HP:0011840)1.85140567
89Increased CSF protein (HP:0002922)1.82069704
90Tented upper lip vermilion (HP:0010804)1.81708267
91Bony spicule pigmentary retinopathy (HP:0007737)1.81519574
92Cone-rod dystrophy (HP:0000548)1.81400052
93Long clavicles (HP:0000890)1.80990439
94Villous atrophy (HP:0011473)1.80180209
95Abnormality of small intestinal villus morphology (HP:0011472)1.80180209
96Protruding tongue (HP:0010808)1.79636436
97Poor coordination (HP:0002370)1.79441964
98Abnormality of potassium homeostasis (HP:0011042)1.79050022
99Bulbous nose (HP:0000414)1.77674758
100Albinism (HP:0001022)1.76678435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.38052245
2BMPR1B3.91180608
3WNK43.89765736
4CDK122.77486552
5MAP4K22.49674170
6MST1R2.20764914
7NME12.19079949
8TAOK32.17262765
9BRD42.13468045
10TXK2.11048560
11INSRR1.85010904
12CAMK1D1.84574361
13WNK11.70453239
14PINK11.69313267
15MET1.69040372
16STK391.61991627
17BLK1.55402901
18EPHA31.47904268
19CDK81.41641461
20CAMK1G1.41443055
21STK381.41022895
22AKT31.39847106
23NUAK11.31659167
24ACVR1B1.28247928
25MAP2K61.22438755
26TNIK1.22358163
27GRK11.21298669
28OXSR11.20705946
29PIK3CA1.18479375
30MAPK131.13757214
31CSNK1A1L1.11426959
32TNK21.07323207
33WNK31.06085385
34MAP4K11.05501464
35NLK1.03139404
36TGFBR11.02283022
37CAMKK21.01902409
38ADRBK20.98379409
39ZAK0.97158420
40MARK30.90205053
41SIK30.89247433
42STK38L0.88755120
43MAPK110.88426480
44PTK2B0.86203399
45TRIM280.85111739
46MAP3K40.84814523
47CASK0.84774562
48BCR0.84021856
49KIT0.83506027
50CHUK0.82694319
51PLK40.80351990
52MKNK20.79168056
53TEC0.78842513
54ATR0.78531197
55MUSK0.78413261
56BCKDK0.78340114
57PLK20.72388926
58ERBB20.72190433
59CDK30.72126932
60MAPK150.70524135
61MKNK10.70239664
62CSNK1G30.69277550
63PAK30.69115906
64SYK0.68074806
65CSNK1G10.67151116
66FES0.64969515
67MAP3K70.64508216
68CAMK40.64321980
69PRKAA20.63305963
70CDK90.63209560
71PRKAA10.62350552
72ITK0.60204092
73LCK0.59706206
74PDK20.59173749
75FGFR20.57504422
76SIK20.55129383
77NEK20.54725786
78VRK10.49702380
79ATM0.48448432
80RPS6KA50.47637473
81IKBKB0.46197061
82TRPM70.45936149
83PRKCE0.45568705
84CLK10.44378752
85MAPK10.43506774
86GRK60.43170651
87ZAP700.41430180
88TLK10.40948115
89CAMK10.40854126
90SGK10.40790238
91SRPK10.40432355
92DAPK20.37599075
93PRKCQ0.37211755
94CSNK1A10.37007241
95IKBKE0.36693516
96BTK0.36237922
97HCK0.36034344
98LYN0.35691987
99CHEK10.35525631
100MTOR0.33516023

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.08927204
2Lysine degradation_Homo sapiens_hsa003102.96198383
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.68022521
4Primary immunodeficiency_Homo sapiens_hsa053402.40730591
5* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.34811835
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29352420
7Butanoate metabolism_Homo sapiens_hsa006502.27177999
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15392855
9ABC transporters_Homo sapiens_hsa020102.03802508
10Phototransduction_Homo sapiens_hsa047442.01389450
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99149241
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.96116152
13Non-homologous end-joining_Homo sapiens_hsa034501.83590041
14Nitrogen metabolism_Homo sapiens_hsa009101.72854982
15RNA polymerase_Homo sapiens_hsa030201.72846834
16Homologous recombination_Homo sapiens_hsa034401.71260904
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66765756
18Graft-versus-host disease_Homo sapiens_hsa053321.64559649
19Linoleic acid metabolism_Homo sapiens_hsa005911.62362945
20* Oocyte meiosis_Homo sapiens_hsa041141.62099572
21Olfactory transduction_Homo sapiens_hsa047401.61917800
22Basal transcription factors_Homo sapiens_hsa030221.55725538
23Ether lipid metabolism_Homo sapiens_hsa005651.54988624
24Type I diabetes mellitus_Homo sapiens_hsa049401.52702169
25Dorso-ventral axis formation_Homo sapiens_hsa043201.50316654
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.41170687
27Taste transduction_Homo sapiens_hsa047421.37134161
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33214870
29Autoimmune thyroid disease_Homo sapiens_hsa053201.31937378
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29814890
31Asthma_Homo sapiens_hsa053101.27889664
32Allograft rejection_Homo sapiens_hsa053301.27652119
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.26927349
34Salivary secretion_Homo sapiens_hsa049701.22064838
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.21897669
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16727130
37RNA degradation_Homo sapiens_hsa030181.12182971
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09753272
39One carbon pool by folate_Homo sapiens_hsa006701.08999974
40Antigen processing and presentation_Homo sapiens_hsa046121.04803257
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03819564
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01557084
43Regulation of autophagy_Homo sapiens_hsa041401.01354269
44Base excision repair_Homo sapiens_hsa034101.00663220
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00395434
46Propanoate metabolism_Homo sapiens_hsa006400.98927294
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.90914586
48Type II diabetes mellitus_Homo sapiens_hsa049300.90270603
49Insulin secretion_Homo sapiens_hsa049110.89437323
50Peroxisome_Homo sapiens_hsa041460.88095099
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.85863813
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82272394
53Choline metabolism in cancer_Homo sapiens_hsa052310.80413062
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.78182007
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76861018
56Glycerolipid metabolism_Homo sapiens_hsa005610.76460161
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75790063
58RNA transport_Homo sapiens_hsa030130.75463776
59Hematopoietic cell lineage_Homo sapiens_hsa046400.75411622
60Calcium signaling pathway_Homo sapiens_hsa040200.74094981
61Circadian rhythm_Homo sapiens_hsa047100.73991685
62Herpes simplex infection_Homo sapiens_hsa051680.72780760
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71819027
64Other glycan degradation_Homo sapiens_hsa005110.71767855
65Circadian entrainment_Homo sapiens_hsa047130.67286314
66Inositol phosphate metabolism_Homo sapiens_hsa005620.66276904
67Tryptophan metabolism_Homo sapiens_hsa003800.61801186
68Selenocompound metabolism_Homo sapiens_hsa004500.59954556
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.57321333
70Purine metabolism_Homo sapiens_hsa002300.55344019
71mTOR signaling pathway_Homo sapiens_hsa041500.55035841
72Amphetamine addiction_Homo sapiens_hsa050310.53577730
73T cell receptor signaling pathway_Homo sapiens_hsa046600.53220868
74Glucagon signaling pathway_Homo sapiens_hsa049220.49208067
75Glutamatergic synapse_Homo sapiens_hsa047240.48971154
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48738943
77Ovarian steroidogenesis_Homo sapiens_hsa049130.47595455
78Platelet activation_Homo sapiens_hsa046110.47140679
79Pancreatic secretion_Homo sapiens_hsa049720.45635003
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44099973
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.43375257
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42294975
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42060859
84cAMP signaling pathway_Homo sapiens_hsa040240.41817588
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41672917
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37826957
87Arachidonic acid metabolism_Homo sapiens_hsa005900.37403338
88Measles_Homo sapiens_hsa051620.35889947
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35157524
90Viral myocarditis_Homo sapiens_hsa054160.34970754
91Notch signaling pathway_Homo sapiens_hsa043300.33803712
92African trypanosomiasis_Homo sapiens_hsa051430.33702786
93Insulin resistance_Homo sapiens_hsa049310.33133753
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33103522
95Fatty acid biosynthesis_Homo sapiens_hsa000610.32634081
96Nicotine addiction_Homo sapiens_hsa050330.32571603
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32322548
98Staphylococcus aureus infection_Homo sapiens_hsa051500.32122400
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29943339
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29773389

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