SPDYE18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.43361474
2acrosome reaction (GO:0007340)6.39504286
3multicellular organism reproduction (GO:0032504)5.59438704
4rRNA catabolic process (GO:0016075)5.11802640
5spermatid nucleus differentiation (GO:0007289)4.98956689
6protein localization to cilium (GO:0061512)4.89889173
7spermatid development (GO:0007286)4.78438297
8single strand break repair (GO:0000012)4.74010341
9fusion of sperm to egg plasma membrane (GO:0007342)4.70896332
10phosphatidylethanolamine biosynthetic process (GO:0006646)4.62020482
11sperm-egg recognition (GO:0035036)4.54492468
12cellular ketone body metabolic process (GO:0046950)4.51256626
13phosphatidylethanolamine metabolic process (GO:0046337)4.39496229
14response to pheromone (GO:0019236)4.36098660
15DNA double-strand break processing (GO:0000729)4.34442324
16coenzyme catabolic process (GO:0009109)4.27811784
17reproduction (GO:0000003)4.23168105
18epithelial cilium movement (GO:0003351)4.21689461
19protein targeting to Golgi (GO:0000042)4.19327821
20rRNA methylation (GO:0031167)4.18643471
21cellular response to ATP (GO:0071318)4.13448968
22establishment of protein localization to Golgi (GO:0072600)4.07428743
23motile cilium assembly (GO:0044458)4.05317069
24L-fucose catabolic process (GO:0042355)4.04356172
25fucose catabolic process (GO:0019317)4.04356172
26L-fucose metabolic process (GO:0042354)4.04356172
27mannosylation (GO:0097502)4.03466805
28cell-cell recognition (GO:0009988)3.96447565
29cell wall macromolecule catabolic process (GO:0016998)3.94104625
30ketone body metabolic process (GO:1902224)3.92721828
31regulation of phosphoprotein phosphatase activity (GO:0043666)3.92311714
32male meiosis (GO:0007140)3.89649852
33binding of sperm to zona pellucida (GO:0007339)3.84418048
34plasma membrane fusion (GO:0045026)3.81431765
35protein localization to Golgi apparatus (GO:0034067)3.79563715
36retrograde transport, vesicle recycling within Golgi (GO:0000301)3.75117016
37regulation of autophagic vacuole assembly (GO:2000785)3.70473571
38single fertilization (GO:0007338)3.69516932
39axonemal dynein complex assembly (GO:0070286)3.69305877
40receptor guanylyl cyclase signaling pathway (GO:0007168)3.66419397
41rRNA modification (GO:0000154)3.65947637
42cell wall macromolecule metabolic process (GO:0044036)3.65719929
43sperm capacitation (GO:0048240)3.58666459
44ncRNA catabolic process (GO:0034661)3.40542997
45cilium movement (GO:0003341)3.40189680
46seminiferous tubule development (GO:0072520)3.39347949
47glomerular visceral epithelial cell development (GO:0072015)3.38250505
48protein polyglutamylation (GO:0018095)3.36867366
49histone H2A monoubiquitination (GO:0035518)3.36100896
50negative regulation of thymocyte apoptotic process (GO:0070244)3.32079441
51protein K63-linked deubiquitination (GO:0070536)3.29194815
52calcium ion-dependent exocytosis (GO:0017156)3.27818528
53sleep (GO:0030431)3.25750758
54negative regulation of telomere maintenance (GO:0032205)3.24996598
55cofactor catabolic process (GO:0051187)3.21122214
56regulation of cilium movement (GO:0003352)3.15838512
57histone H2A ubiquitination (GO:0033522)3.15646899
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10174834
59positive regulation of catecholamine secretion (GO:0033605)3.10064782
60glomerular epithelial cell development (GO:0072310)3.01786534
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01418737
62spermatogenesis (GO:0007283)3.00594677
63cGMP biosynthetic process (GO:0006182)2.99801733
64mast cell degranulation (GO:0043303)2.99589139
65mast cell activation involved in immune response (GO:0002279)2.99589139
66male gamete generation (GO:0048232)2.99385922
67cellular response to interleukin-15 (GO:0071350)2.98311051
68organic cation transport (GO:0015695)2.93428796
69germ cell development (GO:0007281)2.91781506
70inositol phosphate catabolic process (GO:0071545)2.88960719
71microtubule depolymerization (GO:0007019)2.88511892
72regulation of telomere maintenance (GO:0032204)2.88025754
73cilium or flagellum-dependent cell motility (GO:0001539)2.87860131
74dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.86768572
75fertilization (GO:0009566)2.81316094
76regulation of vacuole organization (GO:0044088)2.80089805
77gamete generation (GO:0007276)2.79554774
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78472308
79thyroid gland development (GO:0030878)2.75883123
80cGMP metabolic process (GO:0046068)2.75163551
81detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.73388200
82positive regulation of interleukin-4 production (GO:0032753)2.71493240
83cilium organization (GO:0044782)2.69223858
84maturation of 5.8S rRNA (GO:0000460)2.68230432
85N-acetylneuraminate metabolic process (GO:0006054)2.63532894
86DNA packaging (GO:0006323)2.63331251
87urinary tract smooth muscle contraction (GO:0014848)2.60309292
88positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59230547
89regulation of T cell mediated cytotoxicity (GO:0001914)2.57809632
90relaxation of smooth muscle (GO:0044557)2.57448224
91UDP-N-acetylglucosamine metabolic process (GO:0006047)2.57276595
92RNA localization (GO:0006403)2.53913048
93cAMP catabolic process (GO:0006198)2.51236849
94response to acidic pH (GO:0010447)2.50780893
95nephron tubule morphogenesis (GO:0072078)2.50287374
96nephron epithelium morphogenesis (GO:0072088)2.50287374
97cranial nerve morphogenesis (GO:0021602)2.49601404
98N-acetylglucosamine metabolic process (GO:0006044)2.48253619
99positive regulation of prostaglandin secretion (GO:0032308)2.47202025
100cilium assembly (GO:0042384)2.45940152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.77586391
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.73779797
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21706125
4VDR_22108803_ChIP-Seq_LS180_Human2.72995069
5ZNF274_21170338_ChIP-Seq_K562_Hela2.58973655
6IGF1R_20145208_ChIP-Seq_DFB_Human2.54982390
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.46269555
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30308074
9ER_23166858_ChIP-Seq_MCF-7_Human2.16087293
10AR_21572438_ChIP-Seq_LNCaP_Human2.10982218
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.10114804
12CBP_20019798_ChIP-Seq_JUKART_Human2.06421174
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.06421174
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95837111
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94402721
16NANOG_20526341_ChIP-Seq_ESCs_Human1.84256744
17GBX2_23144817_ChIP-Seq_PC3_Human1.83897899
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82947438
19ERA_21632823_ChIP-Seq_H3396_Human1.82465707
20P300_19829295_ChIP-Seq_ESCs_Human1.75127526
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.73239020
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70242917
23RUNX_20019798_ChIP-Seq_JUKART_Human1.69238084
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68780958
25MYC_18940864_ChIP-ChIP_HL60_Human1.64999902
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.64157495
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64157495
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61865524
29MYC_19829295_ChIP-Seq_ESCs_Human1.58646825
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.58236494
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57160054
32PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.52288234
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51276392
34TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.49943494
35GATA3_26560356_Chip-Seq_TH2_Human1.48705678
36OCT4_20526341_ChIP-Seq_ESCs_Human1.48288338
37TAF2_19829295_ChIP-Seq_ESCs_Human1.47485224
38HOXB7_26014856_ChIP-Seq_BT474_Human1.46843761
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.46133709
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42315702
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41859960
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41727331
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.41727331
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.41573014
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.37028019
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36831430
47RAC3_21632823_ChIP-Seq_H3396_Human1.35398508
48NANOG_19829295_ChIP-Seq_ESCs_Human1.35345100
49SOX2_19829295_ChIP-Seq_ESCs_Human1.35345100
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33604256
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.33413397
52NCOR_22424771_ChIP-Seq_293T_Human1.32590692
53FUS_26573619_Chip-Seq_HEK293_Human1.31791368
54TP53_22573176_ChIP-Seq_HFKS_Human1.27484644
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26283389
56FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26043565
57AR_20517297_ChIP-Seq_VCAP_Human1.22171977
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22130999
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.21550176
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20296815
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.19477999
62RBPJ_21746931_ChIP-Seq_IB4_Human1.19419143
63EWS_26573619_Chip-Seq_HEK293_Human1.18935957
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18373297
65RUNX2_22187159_ChIP-Seq_PCA_Human1.18251404
66GATA3_26560356_Chip-Seq_TH1_Human1.18240129
67GATA3_27048872_Chip-Seq_THYMUS_Human1.18175451
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17861931
69SMAD4_21799915_ChIP-Seq_A2780_Human1.16899997
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15027902
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14689578
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.13661990
73AR_25329375_ChIP-Seq_VCAP_Human1.12213701
74E2F1_20622854_ChIP-Seq_HELA_Human1.11870095
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11143128
76GATA6_21074721_ChIP-Seq_CACO-2_Human1.11139203
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11013510
78ETV1_20927104_ChIP-Seq_GIST48_Human1.10661556
79FOXH1_21741376_ChIP-Seq_ESCs_Human1.10157475
80STAT1_20625510_ChIP-Seq_HELA_Human1.09891031
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09816125
82ERG_20517297_ChIP-Seq_VCAP_Human1.09775649
83PHF8_20622853_ChIP-Seq_HELA_Human1.09641337
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09597118
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09354180
86TBL1_22424771_ChIP-Seq_293T_Human1.09283220
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08850023
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08458807
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08231425
90CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07531540
91STAT3_23295773_ChIP-Seq_U87_Human1.07304550
92TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06551347
93NFYB_21822215_ChIP-Seq_K562_Human1.01780380
94P300_27268052_Chip-Seq_Bcells_Human1.01603943
95PHF8_20622854_ChIP-Seq_HELA_Human1.01028877
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00943642
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00869765
98TCF4_22108803_ChIP-Seq_LS180_Human1.00330867
99NFYA_21822215_ChIP-Seq_K562_Human0.99793364
100MYB_26560356_Chip-Seq_TH2_Human0.97682162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.95712350
2MP0002102_abnormal_ear_morphology3.59615291
3MP0002132_abnormal_respiratory_system2.49578625
4MP0001501_abnormal_sleep_pattern2.48945282
5MP0003011_delayed_dark_adaptation2.47696102
6MP0003698_abnormal_male_reproductive2.30293738
7MP0004147_increased_porphyrin_level2.27322548
8MP0000569_abnormal_digit_pigmentation2.22308794
9MP0001929_abnormal_gametogenesis2.20212569
10MP0005551_abnormal_eye_electrophysiolog2.12314942
11MP0003878_abnormal_ear_physiology2.10894790
12MP0005377_hearing/vestibular/ear_phenot2.10894790
13MP0005075_abnormal_melanosome_morpholog2.02155935
14MP0004885_abnormal_endolymph2.01240672
15MP0008995_early_reproductive_senescence1.98219021
16MP0005174_abnormal_tail_pigmentation1.97504574
17MP0002837_dystrophic_cardiac_calcinosis1.94069668
18MP0005671_abnormal_response_to1.88735438
19MP0006072_abnormal_retinal_apoptosis1.86574436
20MP0008877_abnormal_DNA_methylation1.80870172
21MP0002638_abnormal_pupillary_reflex1.67907776
22MP0002282_abnormal_trachea_morphology1.64111760
23MP0000678_abnormal_parathyroid_gland1.56537259
24MP0000470_abnormal_stomach_morphology1.50778498
25MP0004742_abnormal_vestibular_system1.49467625
26MP0003646_muscle_fatigue1.48732782
27MP0005670_abnormal_white_adipose1.48049490
28MP0001968_abnormal_touch/_nociception1.47454417
29MP0001270_distended_abdomen1.46839973
30MP0003724_increased_susceptibility_to1.45833171
31MP0008004_abnormal_stomach_pH1.45723600
32MP0003195_calcinosis1.43447917
33MP0001188_hyperpigmentation1.42853394
34MP0001984_abnormal_olfaction1.40156681
35MP0002127_abnormal_cardiovascular_syste1.33822627
36MP0005253_abnormal_eye_physiology1.32222278
37MP0001485_abnormal_pinna_reflex1.31251222
38MP0004036_abnormal_muscle_relaxation1.28922656
39MP0002277_abnormal_respiratory_mucosa1.26013172
40MP0003693_abnormal_embryo_hatching1.23380036
41MP0008875_abnormal_xenobiotic_pharmacok1.22881558
42MP0000465_gastrointestinal_hemorrhage1.21749478
43MP0001765_abnormal_ion_homeostasis1.21746062
44MP0005646_abnormal_pituitary_gland1.19596510
45MP0001529_abnormal_vocalization1.16712605
46MP0009785_altered_susceptibility_to1.15598691
47MP0002249_abnormal_larynx_morphology1.14687568
48MP0001664_abnormal_digestion1.13971554
49MP0003283_abnormal_digestive_organ1.10821436
50MP0003718_maternal_effect1.10027160
51MP0002160_abnormal_reproductive_system1.10014518
52MP0001502_abnormal_circadian_rhythm1.09493559
53MP0001835_abnormal_antigen_presentation1.08465768
54MP0002272_abnormal_nervous_system1.07127019
55MP0003879_abnormal_hair_cell1.05570245
56MP0000372_irregular_coat_pigmentation1.05362053
57MP0002161_abnormal_fertility/fecundity1.02683056
58MP0004084_abnormal_cardiac_muscle0.99789990
59MP0002229_neurodegeneration0.99225111
60MP0003300_gastrointestinal_ulcer0.98802832
61MP0003786_premature_aging0.97984187
62MP0005310_abnormal_salivary_gland0.97970571
63MP0001963_abnormal_hearing_physiology0.96610758
64MP0002736_abnormal_nociception_after0.95667336
65MP0001486_abnormal_startle_reflex0.95552895
66MP0000015_abnormal_ear_pigmentation0.94956543
67MP0002210_abnormal_sex_determination0.94129330
68MP0000653_abnormal_sex_gland0.92588363
69MP0008007_abnormal_cellular_replicative0.92423997
70MP0003890_abnormal_embryonic-extraembry0.90700488
71MP0002876_abnormal_thyroid_physiology0.90352290
72MP0005636_abnormal_mineral_homeostasis0.90085369
73MP0005389_reproductive_system_phenotype0.89959583
74MP0001145_abnormal_male_reproductive0.87030021
75MP0004782_abnormal_surfactant_physiolog0.86608781
76MP0001905_abnormal_dopamine_level0.84408774
77MP0002723_abnormal_immune_serum0.83710311
78MP0004142_abnormal_muscle_tone0.83565488
79MP0005084_abnormal_gallbladder_morpholo0.82907201
80MP0000230_abnormal_systemic_arterial0.82707555
81MP0000681_abnormal_thyroid_gland0.80490550
82MP0003638_abnormal_response/metabolism_0.79504445
83MP0000026_abnormal_inner_ear0.78395822
84MP0009745_abnormal_behavioral_response0.77177868
85MP0008058_abnormal_DNA_repair0.77082246
86MP0009697_abnormal_copulation0.76948529
87MP0003315_abnormal_perineum_morphology0.75917877
88MP0000703_abnormal_thymus_morphology0.75676409
89MP0005083_abnormal_biliary_tract0.75435934
90MP0001661_extended_life_span0.74980670
91MP0006292_abnormal_olfactory_placode0.74148048
92MP0001800_abnormal_humoral_immune0.74110387
93MP0004233_abnormal_muscle_weight0.72878086
94MP0003136_yellow_coat_color0.71500230
95MP0003866_abnormal_defecation0.71342453
96MP0009046_muscle_twitch0.68492729
97MP0001666_abnormal_nutrient_absorption0.68014361
98MP0008775_abnormal_heart_ventricle0.66866663
99MP0002557_abnormal_social/conspecific_i0.66763651
100MP0006035_abnormal_mitochondrial_morpho0.66689793

Predicted human phenotypes

RankGene SetZ-score
1Decreased central vision (HP:0007663)4.74916691
2Abnormal rod and cone electroretinograms (HP:0008323)4.59460526
3Reduced antithrombin III activity (HP:0001976)4.35104445
4Stomatitis (HP:0010280)4.16195800
5Attenuation of retinal blood vessels (HP:0007843)4.09328813
6Chronic hepatic failure (HP:0100626)3.66494892
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.61770727
8Bony spicule pigmentary retinopathy (HP:0007737)3.47127489
9Absent/shortened dynein arms (HP:0200106)3.47087956
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.47087956
11Severe visual impairment (HP:0001141)3.45346693
12Hypoproteinemia (HP:0003075)3.40034229
13Abnormality of DNA repair (HP:0003254)3.37259361
14Duplicated collecting system (HP:0000081)3.34165907
15Nephronophthisis (HP:0000090)3.33914898
16Type I transferrin isoform profile (HP:0003642)3.33436284
17Abnormality of the renal cortex (HP:0011035)3.27238987
18Increased corneal curvature (HP:0100692)3.18113785
19Keratoconus (HP:0000563)3.18113785
20Progressive inability to walk (HP:0002505)3.13094772
21Methylmalonic acidemia (HP:0002912)3.12317747
22Hypoplasia of the pons (HP:0012110)3.02305599
23Abnormality of the renal medulla (HP:0100957)3.01388460
24Abnormality of the pons (HP:0007361)2.99114726
25Renal cortical cysts (HP:0000803)2.96626821
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.93226649
27Abnormal protein N-linked glycosylation (HP:0012347)2.93226649
28Abnormal protein glycosylation (HP:0012346)2.93226649
29Abnormal glycosylation (HP:0012345)2.93226649
30Abnormality of the renal collecting system (HP:0004742)2.92425350
31Cone-rod dystrophy (HP:0000548)2.91090301
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.83549512
33Enlarged epiphyses (HP:0010580)2.81938869
34Pancreatic cysts (HP:0001737)2.80483344
35Inability to walk (HP:0002540)2.79295682
36Pancreatic fibrosis (HP:0100732)2.77844962
37Methylmalonic aciduria (HP:0012120)2.76116271
38Abnormality of midbrain morphology (HP:0002418)2.75221596
39Molar tooth sign on MRI (HP:0002419)2.75221596
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74252018
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74252018
42Type II lissencephaly (HP:0007260)2.70214601
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68973858
44Facial diplegia (HP:0001349)2.68465726
45Abnormality of macular pigmentation (HP:0008002)2.63296216
46Azoospermia (HP:0000027)2.62046264
47Thyroiditis (HP:0100646)2.59797773
48Abnormal ciliary motility (HP:0012262)2.51662504
49Abnormal respiratory motile cilium morphology (HP:0005938)2.43151869
50Abnormal respiratory epithelium morphology (HP:0012253)2.43151869
51Tubulointerstitial nephritis (HP:0001970)2.42424804
52Hypochromic microcytic anemia (HP:0004840)2.37851754
53Severe combined immunodeficiency (HP:0004430)2.30438532
54Esophageal atresia (HP:0002032)2.28342607
55Large for gestational age (HP:0001520)2.28265835
56Congenital stationary night blindness (HP:0007642)2.28059868
57Abnormal biliary tract physiology (HP:0012439)2.27312041
58Bile duct proliferation (HP:0001408)2.27312041
59Abolished electroretinogram (ERG) (HP:0000550)2.26892446
60Absent thumb (HP:0009777)2.26239216
61Gastrointestinal atresia (HP:0002589)2.25829061
62Abnormality of the vitamin B12 metabolism (HP:0004341)2.25335460
63True hermaphroditism (HP:0010459)2.23574997
64Polydipsia (HP:0001959)2.20735681
65Abnormal drinking behavior (HP:0030082)2.20735681
66IgG deficiency (HP:0004315)2.19338398
67Impulsivity (HP:0100710)2.17190027
68Tubular atrophy (HP:0000092)2.16861769
69Medial flaring of the eyebrow (HP:0010747)2.15769242
70Abnormality of vitamin B metabolism (HP:0004340)2.15442886
71Cerebellar dysplasia (HP:0007033)2.14742104
72Retinal dysplasia (HP:0007973)2.14339037
73Abnormal spermatogenesis (HP:0008669)2.11441485
74Abnormal respiratory motile cilium physiology (HP:0012261)2.09835375
75Macular degeneration (HP:0000608)2.09734606
76Abnormality of eosinophils (HP:0001879)2.09330894
77IgM deficiency (HP:0002850)2.07720643
78B lymphocytopenia (HP:0010976)2.07556836
79Clubbing of toes (HP:0100760)2.04533918
80Cystic liver disease (HP:0006706)2.03541733
81Hyperkalemia (HP:0002153)2.00075040
82Constricted visual fields (HP:0001133)1.98378254
83Abnormality of B cell number (HP:0010975)1.96745486
84Intestinal atresia (HP:0011100)1.94920822
85Abnormal EKG (HP:0003115)1.91767688
86Pendular nystagmus (HP:0012043)1.91506599
87Clumsiness (HP:0002312)1.82963104
88Thoracic kyphosis (HP:0002942)1.82681464
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.81731869
90Infertility (HP:0000789)1.81407266
91Polyuria (HP:0000103)1.80758475
92Type II diabetes mellitus (HP:0005978)1.80397264
93Abnormality of the columella (HP:0009929)1.78993027
94Ketosis (HP:0001946)1.78205203
95Abnormality of the ileum (HP:0001549)1.78194292
96Photophobia (HP:0000613)1.77838763
97Unsteady gait (HP:0002317)1.68864230
98Prolonged QT interval (HP:0001657)1.68425519
99Delayed gross motor development (HP:0002194)1.67817553
100Abnormal biliary tract morphology (HP:0012440)1.67365175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.13024726
2PINK13.78110170
3FRK3.36801811
4TAOK33.14189945
5EIF2AK32.87737665
6ZAK2.77808354
7TLK12.65902813
8NME12.64863031
9MUSK2.46565313
10WNK42.37735794
11GRK12.20821974
12INSRR2.09407018
13PLK42.02703022
14ADRBK22.01478580
15MARK31.83854076
16GRK61.71160689
17FES1.66291108
18KIT1.64049851
19BMPR1B1.62042590
20IKBKB1.61374561
21TEC1.46547160
22OBSCN1.45158340
23TNIK1.41878342
24OXSR11.39288010
25VRK11.36830818
26TIE11.36774830
27CDK31.35681294
28WNK31.25228481
29ITK1.24489036
30LATS11.17458243
31STK161.14590983
32IKBKE1.14015414
33MAP2K21.13277913
34MAPK151.11002177
35WNK11.06689014
36RPS6KA41.06598139
37MST1R1.06576568
38NEK21.03631338
39NUAK11.01645837
40MAPKAPK30.98155351
41CAMKK20.96504803
42MATK0.91282399
43BTK0.88216330
44FGFR20.80803572
45PTK2B0.80342057
46RPS6KA50.80340073
47DAPK20.79498471
48MAP4K10.77234306
49VRK20.76536110
50PHKG20.75649741
51PHKG10.75649741
52MAP2K60.75222342
53PRKCQ0.74336384
54SYK0.73471211
55MAP2K70.69850848
56PLK20.67995698
57PIK3CG0.66890773
58CSNK1G30.66874442
59STK390.64088854
60STK380.62155561
61RPS6KA60.60874149
62CSNK1A1L0.59807299
63CSNK1G10.59527208
64TXK0.57684489
65MAPK130.53429216
66LCK0.52579366
67TRPM70.51616280
68RPS6KA20.50339192
69PRKCE0.49292332
70MAPK70.49288087
71CSNK1G20.48624184
72CHUK0.46756564
73HCK0.46421411
74RPS6KC10.45343786
75RPS6KL10.45343786
76STK38L0.45268963
77IGF1R0.44982185
78LYN0.44950718
79PAK30.44656721
80CAMK1G0.43434214
81ATR0.43003593
82ATM0.41188559
83PNCK0.40869110
84NLK0.39423032
85CAMK10.37114534
86CSNK1A10.36861726
87BCKDK0.35355604
88PRKG10.35172064
89PDK10.35098044
90RPS6KA10.33177268
91MINK10.31618047
92MET0.30857272
93MYLK0.30831059
94PIK3CA0.27340936
95ERBB20.26490729
96DYRK20.26396017
97MAPK100.26303932
98MAPK10.25814649
99PLK30.25368470
100CAMK40.25173129

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.94347056
2Phototransduction_Homo sapiens_hsa047443.01674166
3Olfactory transduction_Homo sapiens_hsa047402.94765512
4Allograft rejection_Homo sapiens_hsa053302.69103495
5Graft-versus-host disease_Homo sapiens_hsa053322.66561258
6Autoimmune thyroid disease_Homo sapiens_hsa053202.65164049
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.57077371
8Type I diabetes mellitus_Homo sapiens_hsa049402.51806659
9Butanoate metabolism_Homo sapiens_hsa006502.40267304
10Asthma_Homo sapiens_hsa053102.22236206
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14681659
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05845905
13Circadian rhythm_Homo sapiens_hsa047101.88477021
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86189269
15Fanconi anemia pathway_Homo sapiens_hsa034601.81758965
16Nitrogen metabolism_Homo sapiens_hsa009101.75929818
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68137642
18Selenocompound metabolism_Homo sapiens_hsa004501.60539156
19One carbon pool by folate_Homo sapiens_hsa006701.57476200
20RNA degradation_Homo sapiens_hsa030181.52486241
21Antigen processing and presentation_Homo sapiens_hsa046121.51117499
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49381296
23Primary immunodeficiency_Homo sapiens_hsa053401.48655649
24Purine metabolism_Homo sapiens_hsa002301.41503016
25ABC transporters_Homo sapiens_hsa020101.32404170
26Taste transduction_Homo sapiens_hsa047421.32354550
27RNA polymerase_Homo sapiens_hsa030201.25747306
28Vitamin digestion and absorption_Homo sapiens_hsa049771.20644378
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20600026
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19794214
31Oocyte meiosis_Homo sapiens_hsa041141.19679351
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.18564258
33Linoleic acid metabolism_Homo sapiens_hsa005911.17368352
34RNA transport_Homo sapiens_hsa030131.16691938
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16661614
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16655205
37Chemical carcinogenesis_Homo sapiens_hsa052041.11500373
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04814829
39Propanoate metabolism_Homo sapiens_hsa006401.03623265
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02021296
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98758503
42Circadian entrainment_Homo sapiens_hsa047130.95855910
43Homologous recombination_Homo sapiens_hsa034400.94444653
44Salivary secretion_Homo sapiens_hsa049700.92564205
45Herpes simplex infection_Homo sapiens_hsa051680.92379738
46Caffeine metabolism_Homo sapiens_hsa002320.90920518
47beta-Alanine metabolism_Homo sapiens_hsa004100.90624906
48N-Glycan biosynthesis_Homo sapiens_hsa005100.90269259
49Tryptophan metabolism_Homo sapiens_hsa003800.89934726
50Viral myocarditis_Homo sapiens_hsa054160.86586592
51Glycerolipid metabolism_Homo sapiens_hsa005610.85797074
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85049872
53Basal transcription factors_Homo sapiens_hsa030220.82838409
54Ether lipid metabolism_Homo sapiens_hsa005650.79050166
55Staphylococcus aureus infection_Homo sapiens_hsa051500.78324180
56Proteasome_Homo sapiens_hsa030500.77335990
57Histidine metabolism_Homo sapiens_hsa003400.74368376
58Oxytocin signaling pathway_Homo sapiens_hsa049210.72052773
59Systemic lupus erythematosus_Homo sapiens_hsa053220.71923597
60Rheumatoid arthritis_Homo sapiens_hsa053230.71920817
61Arachidonic acid metabolism_Homo sapiens_hsa005900.71045788
62Retinol metabolism_Homo sapiens_hsa008300.70921597
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70194023
64Hematopoietic cell lineage_Homo sapiens_hsa046400.70150439
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67597216
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66953068
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65471850
68Mineral absorption_Homo sapiens_hsa049780.63917036
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63152853
70Leishmaniasis_Homo sapiens_hsa051400.62483102
71Pyrimidine metabolism_Homo sapiens_hsa002400.61735606
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61654491
73T cell receptor signaling pathway_Homo sapiens_hsa046600.60192606
74Renin secretion_Homo sapiens_hsa049240.60047189
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58771512
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58403312
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55635839
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.55580302
79Hedgehog signaling pathway_Homo sapiens_hsa043400.53769752
80Morphine addiction_Homo sapiens_hsa050320.53527279
81Regulation of autophagy_Homo sapiens_hsa041400.52885138
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51562518
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.49717728
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.44868841
85Arginine and proline metabolism_Homo sapiens_hsa003300.44271166
86Metabolic pathways_Homo sapiens_hsa011000.43766328
87Calcium signaling pathway_Homo sapiens_hsa040200.43119878
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40859800
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.40652237
90Phagosome_Homo sapiens_hsa041450.40295614
91Fatty acid degradation_Homo sapiens_hsa000710.40118676
92Mismatch repair_Homo sapiens_hsa034300.39103600
93Gastric acid secretion_Homo sapiens_hsa049710.37984788
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36489730
95Spliceosome_Homo sapiens_hsa030400.36280060
96Peroxisome_Homo sapiens_hsa041460.35613534
97Serotonergic synapse_Homo sapiens_hsa047260.34278685
98Influenza A_Homo sapiens_hsa051640.33531078
99Insulin secretion_Homo sapiens_hsa049110.33094125
100Gap junction_Homo sapiens_hsa045400.32778792

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