SPDYE11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.91792685
2piRNA metabolic process (GO:0034587)4.50336515
3negative regulation of cytosolic calcium ion concentration (GO:0051481)4.45435638
4regulation of cilium movement (GO:0003352)4.44777450
5behavioral response to ethanol (GO:0048149)4.07005043
6DNA deamination (GO:0045006)3.87607002
7ubiquinone biosynthetic process (GO:0006744)3.81679803
8protein polyglutamylation (GO:0018095)3.78302243
9axoneme assembly (GO:0035082)3.58673406
10epithelial cilium movement (GO:0003351)3.55120283
11ubiquinone metabolic process (GO:0006743)3.50672084
12photoreceptor cell maintenance (GO:0045494)3.49918535
13DNA double-strand break processing (GO:0000729)3.49228629
14cellular ketone body metabolic process (GO:0046950)3.47642550
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47335691
16preassembly of GPI anchor in ER membrane (GO:0016254)3.45387830
17GPI anchor metabolic process (GO:0006505)3.44546579
18L-fucose metabolic process (GO:0042354)3.43883875
19L-fucose catabolic process (GO:0042355)3.43883875
20fucose catabolic process (GO:0019317)3.43883875
21platelet dense granule organization (GO:0060155)3.40457393
22nonmotile primary cilium assembly (GO:0035058)3.35387298
23intraciliary transport (GO:0042073)3.34079356
24seminiferous tubule development (GO:0072520)3.33816461
25positive regulation of mitochondrial fission (GO:0090141)3.32354761
26mannosylation (GO:0097502)3.30377986
27respiratory chain complex IV assembly (GO:0008535)3.30226122
28sperm motility (GO:0030317)3.30089726
29behavioral response to nicotine (GO:0035095)3.28818384
30quinone biosynthetic process (GO:1901663)3.26646908
31centriole replication (GO:0007099)3.26118694
32protein complex biogenesis (GO:0070271)3.23492056
33detection of light stimulus involved in sensory perception (GO:0050962)3.21954012
34detection of light stimulus involved in visual perception (GO:0050908)3.21954012
35indolalkylamine metabolic process (GO:0006586)3.16032299
36neural tube formation (GO:0001841)3.15484022
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.13087712
38cytochrome complex assembly (GO:0017004)3.13078529
39mitochondrial respiratory chain complex assembly (GO:0033108)3.12674910
40retinal cone cell development (GO:0046549)3.12497822
41ketone body metabolic process (GO:1902224)3.12253998
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11867869
43GPI anchor biosynthetic process (GO:0006506)3.09135381
44branched-chain amino acid catabolic process (GO:0009083)3.08458584
45cilium or flagellum-dependent cell motility (GO:0001539)3.08373797
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07636584
47DNA integration (GO:0015074)3.05460074
48replication fork processing (GO:0031297)3.02940122
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01693057
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.01693057
51NADH dehydrogenase complex assembly (GO:0010257)3.01693057
52pyrimidine dimer repair (GO:0006290)2.97983573
53gamma-aminobutyric acid transport (GO:0015812)2.94539046
54cilium morphogenesis (GO:0060271)2.94219721
55mismatch repair (GO:0006298)2.94153317
56microtubule severing (GO:0051013)2.93942446
57cilium organization (GO:0044782)2.93090622
58tryptophan catabolic process (GO:0006569)2.92428308
59indole-containing compound catabolic process (GO:0042436)2.92428308
60indolalkylamine catabolic process (GO:0046218)2.92428308
61tryptophan metabolic process (GO:0006568)2.91843891
62negative regulation of telomere maintenance (GO:0032205)2.89441595
63regulation of microtubule-based movement (GO:0060632)2.88661364
64cilium movement (GO:0003341)2.87922753
65opioid receptor signaling pathway (GO:0038003)2.87894809
66DNA methylation involved in gamete generation (GO:0043046)2.87797869
67cilium assembly (GO:0042384)2.86935733
68establishment of protein localization to Golgi (GO:0072600)2.83540928
69water-soluble vitamin biosynthetic process (GO:0042364)2.80447792
70reciprocal DNA recombination (GO:0035825)2.76910216
71reciprocal meiotic recombination (GO:0007131)2.76910216
72glycolipid biosynthetic process (GO:0009247)2.75598713
73C4-dicarboxylate transport (GO:0015740)2.74565714
74regulation of meiosis I (GO:0060631)2.74275500
75ncRNA catabolic process (GO:0034661)2.73524995
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.72878765
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72878765
78negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.72679803
79photoreceptor cell development (GO:0042461)2.72298866
80recombinational repair (GO:0000725)2.71541358
81acrosome reaction (GO:0007340)2.70632084
82double-strand break repair via homologous recombination (GO:0000724)2.69630773
83spermatid development (GO:0007286)2.66085820
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65953411
85C-terminal protein lipidation (GO:0006501)2.65307154
86multicellular organism reproduction (GO:0032504)2.62803894
87neuronal action potential (GO:0019228)2.62489553
88protein targeting to Golgi (GO:0000042)2.62191152
89histone mRNA catabolic process (GO:0071044)2.61683683
90GMP metabolic process (GO:0046037)2.61328936
91regulation of telomere maintenance (GO:0032204)2.60828728
92branched-chain amino acid metabolic process (GO:0009081)2.58067993
93anterograde synaptic vesicle transport (GO:0048490)2.55382868
94pyrimidine nucleobase catabolic process (GO:0006208)2.55192002
95resolution of meiotic recombination intermediates (GO:0000712)2.55176550
96estrogen biosynthetic process (GO:0006703)2.54462813
97base-excision repair, AP site formation (GO:0006285)2.54089574
98histone H2A acetylation (GO:0043968)2.52889936
99protein localization to Golgi apparatus (GO:0034067)2.52453290
100adenosine metabolic process (GO:0046085)2.52200830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.12348711
2IGF1R_20145208_ChIP-Seq_DFB_Human3.33294154
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08182018
4GBX2_23144817_ChIP-Seq_PC3_Human3.03530353
5VDR_22108803_ChIP-Seq_LS180_Human2.93927463
6TAF15_26573619_Chip-Seq_HEK293_Human2.56987990
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53667534
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44334542
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34517425
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30088547
11FUS_26573619_Chip-Seq_HEK293_Human2.22791914
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21025853
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.14692893
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.12232658
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.12230010
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08083060
17EZH2_22144423_ChIP-Seq_EOC_Human2.07250647
18EWS_26573619_Chip-Seq_HEK293_Human2.05016676
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02880096
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00339640
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94179222
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.90820217
23CBP_20019798_ChIP-Seq_JUKART_Human1.90820217
24P300_19829295_ChIP-Seq_ESCs_Human1.86810882
25ER_23166858_ChIP-Seq_MCF-7_Human1.82013237
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.75102337
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71181419
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69461013
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68875733
30IRF1_19129219_ChIP-ChIP_H3396_Human1.67965333
31TP53_22573176_ChIP-Seq_HFKS_Human1.65258358
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55877029
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55877029
34VDR_23849224_ChIP-Seq_CD4+_Human1.52764131
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50069145
36MYC_18940864_ChIP-ChIP_HL60_Human1.48887902
37STAT3_23295773_ChIP-Seq_U87_Human1.45569132
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43338936
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43333378
40NANOG_19829295_ChIP-Seq_ESCs_Human1.43009807
41SOX2_19829295_ChIP-Seq_ESCs_Human1.43009807
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41748114
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39373035
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39189207
45ELK1_19687146_ChIP-ChIP_HELA_Human1.37745353
46SMAD4_21799915_ChIP-Seq_A2780_Human1.36925394
47TCF4_23295773_ChIP-Seq_U87_Human1.36247045
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33616967
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32894564
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.30956181
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.28606938
52AR_25329375_ChIP-Seq_VCAP_Human1.27378357
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24195772
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.22342538
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22342538
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.20491140
57BCAT_22108803_ChIP-Seq_LS180_Human1.20151542
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19518636
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18554145
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17884693
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.17516321
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17277715
63RUNX2_22187159_ChIP-Seq_PCA_Human1.16284830
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15643991
65FOXP3_21729870_ChIP-Seq_TREG_Human1.14895212
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14689736
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14078351
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13611221
69TCF4_22108803_ChIP-Seq_LS180_Human1.11765292
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11458644
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11138819
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10908705
73NCOR_22424771_ChIP-Seq_293T_Human1.10082765
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09369533
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.09200292
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07751198
77AR_20517297_ChIP-Seq_VCAP_Human1.07342861
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.07288094
79HOXB7_26014856_ChIP-Seq_BT474_Human1.06822382
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.06148688
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.05751489
82RNF2_27304074_Chip-Seq_NSC_Mouse1.05732154
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05558605
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.04782799
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04232023
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03555690
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03509248
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01220870
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00965420
90REST_21632747_ChIP-Seq_MESCs_Mouse1.00461783
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98882007
92ERA_21632823_ChIP-Seq_H3396_Human0.97763541
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.97053128
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96739678
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95912465
96NANOG_20526341_ChIP-Seq_ESCs_Human0.95787168
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.95426693
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95118490
99MYC_19829295_ChIP-Seq_ESCs_Human0.94450568
100WDR5_24793694_ChIP-Seq_LNCAP_Human0.94003866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.47079272
2MP0001968_abnormal_touch/_nociception2.89339369
3MP0008877_abnormal_DNA_methylation2.88089360
4MP0005551_abnormal_eye_electrophysiolog2.67711321
5MP0002102_abnormal_ear_morphology2.61427558
6MP0005646_abnormal_pituitary_gland2.39272788
7MP0008058_abnormal_DNA_repair2.14578609
8MP0006072_abnormal_retinal_apoptosis2.12049294
9MP0005645_abnormal_hypothalamus_physiol2.11808927
10MP0003787_abnormal_imprinting2.04410591
11MP0001986_abnormal_taste_sensitivity1.98949668
12MP0005410_abnormal_fertilization1.94144012
13MP0000015_abnormal_ear_pigmentation1.89076001
14MP0000569_abnormal_digit_pigmentation1.88165718
15MP0006292_abnormal_olfactory_placode1.87605799
16MP0005253_abnormal_eye_physiology1.82571966
17MP0002736_abnormal_nociception_after1.82179264
18MP0001486_abnormal_startle_reflex1.80446860
19MP0000372_irregular_coat_pigmentation1.78311874
20MP0002735_abnormal_chemical_nociception1.76069609
21MP0002876_abnormal_thyroid_physiology1.75761403
22MP0006276_abnormal_autonomic_nervous1.71641852
23MP0008995_early_reproductive_senescence1.71186880
24MP0003136_yellow_coat_color1.69603137
25MP0004147_increased_porphyrin_level1.69480411
26MP0009046_muscle_twitch1.65572866
27MP0001529_abnormal_vocalization1.64535634
28MP0004043_abnormal_pH_regulation1.63796950
29MP0002638_abnormal_pupillary_reflex1.60171446
30MP0008872_abnormal_physiological_respon1.59585282
31MP0008875_abnormal_xenobiotic_pharmacok1.56588514
32MP0009745_abnormal_behavioral_response1.55902326
33MP0003718_maternal_effect1.54970931
34MP0006035_abnormal_mitochondrial_morpho1.54874388
35MP0002272_abnormal_nervous_system1.51210533
36MP0005075_abnormal_melanosome_morpholog1.49684597
37MP0002653_abnormal_ependyma_morphology1.46397102
38MP0001501_abnormal_sleep_pattern1.45179579
39MP0001984_abnormal_olfaction1.43159748
40MP0003195_calcinosis1.41940012
41MP0003646_muscle_fatigue1.40781864
42MP0003698_abnormal_male_reproductive1.36682404
43MP0002837_dystrophic_cardiac_calcinosis1.36204042
44MP0002234_abnormal_pharynx_morphology1.34999820
45MP0008789_abnormal_olfactory_epithelium1.34269175
46MP0009278_abnormal_bone_marrow1.33145600
47MP0010386_abnormal_urinary_bladder1.30989847
48MP0001929_abnormal_gametogenesis1.30380538
49MP0001764_abnormal_homeostasis1.28411726
50MP0002095_abnormal_skin_pigmentation1.23524615
51MP0002733_abnormal_thermal_nociception1.22538115
52MP0005423_abnormal_somatic_nervous1.19439899
53MP0003122_maternal_imprinting1.19179705
54MP0002572_abnormal_emotion/affect_behav1.18245613
55MP0001970_abnormal_pain_threshold1.16222233
56MP0003121_genomic_imprinting1.15883601
57MP0000631_abnormal_neuroendocrine_gland1.14004044
58MP0005499_abnormal_olfactory_system1.13808113
59MP0005394_taste/olfaction_phenotype1.13808113
60MP0004142_abnormal_muscle_tone1.13079731
61MP0005084_abnormal_gallbladder_morpholo1.12277061
62MP0003011_delayed_dark_adaptation1.11974616
63MP0004133_heterotaxia1.07336873
64MP0002067_abnormal_sensory_capabilities1.06741609
65MP0002557_abnormal_social/conspecific_i1.06257132
66MP0001485_abnormal_pinna_reflex1.05248963
67MP0001905_abnormal_dopamine_level1.04622381
68MP0009764_decreased_sensitivity_to1.03707502
69MP0002938_white_spotting1.03553193
70MP0006036_abnormal_mitochondrial_physio1.02485600
71MP0002064_seizures1.00550649
72MP0004742_abnormal_vestibular_system1.00307164
73MP0010094_abnormal_chromosome_stability0.99519239
74MP0005174_abnormal_tail_pigmentation0.98661538
75MP0003635_abnormal_synaptic_transmissio0.98438660
76MP0001324_abnormal_eye_pigmentation0.97441027
77MP0002734_abnormal_mechanical_nocicepti0.94340756
78MP0001963_abnormal_hearing_physiology0.94330129
79MP0000778_abnormal_nervous_system0.93989904
80MP0005397_hematopoietic_system_phenotyp0.92423303
81MP0001545_abnormal_hematopoietic_system0.92423303
82MP0002751_abnormal_autonomic_nervous0.92244571
83MP0002160_abnormal_reproductive_system0.92014857
84MP0002229_neurodegeneration0.91010317
85MP0002752_abnormal_somatic_nervous0.89557896
86MP0005367_renal/urinary_system_phenotyp0.89389179
87MP0000516_abnormal_urinary_system0.89389179
88MP0005195_abnormal_posterior_eye0.87265561
89MP0002210_abnormal_sex_determination0.86069355
90MP0000465_gastrointestinal_hemorrhage0.85463116
91MP0000653_abnormal_sex_gland0.85043448
92MP0003786_premature_aging0.84195568
93MP0008775_abnormal_heart_ventricle0.82742793
94MP0005171_absent_coat_pigmentation0.82494438
95MP0005389_reproductive_system_phenotype0.81022535
96MP0005386_behavior/neurological_phenoty0.80747972
97MP0004924_abnormal_behavior0.80747972
98MP0005167_abnormal_blood-brain_barrier0.79498337
99MP0000427_abnormal_hair_cycle0.78631757
100MP0002069_abnormal_eating/drinking_beha0.77654552

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.19901725
2Pancreatic fibrosis (HP:0100732)4.03863251
3True hermaphroditism (HP:0010459)3.89372242
4Abnormality of midbrain morphology (HP:0002418)3.54607268
5Molar tooth sign on MRI (HP:0002419)3.54607268
6Nephronophthisis (HP:0000090)3.43250298
7Medial flaring of the eyebrow (HP:0010747)3.41700989
8Thyroid-stimulating hormone excess (HP:0002925)3.21716954
9Abnormality of the renal medulla (HP:0100957)3.06554933
10Tubulointerstitial nephritis (HP:0001970)2.97358123
11Abnormality of the renal cortex (HP:0011035)2.91269262
12Aplasia/Hypoplasia of the tibia (HP:0005772)2.89715838
13Congenital stationary night blindness (HP:0007642)2.87265078
14Chronic hepatic failure (HP:0100626)2.85788949
15Gait imbalance (HP:0002141)2.85100757
16Congenital primary aphakia (HP:0007707)2.83115451
17Attenuation of retinal blood vessels (HP:0007843)2.80513651
18Nephrogenic diabetes insipidus (HP:0009806)2.77286326
19Cystic liver disease (HP:0006706)2.70723345
20Hepatocellular necrosis (HP:0001404)2.69681369
21Progressive inability to walk (HP:0002505)2.66484234
22Focal motor seizures (HP:0011153)2.65495179
23Type II lissencephaly (HP:0007260)2.63199082
24Renal cortical cysts (HP:0000803)2.55992550
25Abnormality of macular pigmentation (HP:0008002)2.54965583
26Abolished electroretinogram (ERG) (HP:0000550)2.54538193
27Short tibia (HP:0005736)2.53494847
28Bile duct proliferation (HP:0001408)2.52895078
29Abnormal biliary tract physiology (HP:0012439)2.52895078
30Inability to walk (HP:0002540)2.51943236
31Abnormal rod and cone electroretinograms (HP:0008323)2.49697954
32Hyperventilation (HP:0002883)2.48715034
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.47868075
34Hepatic necrosis (HP:0002605)2.45992810
35Gaze-evoked nystagmus (HP:0000640)2.41568429
36Mitochondrial inheritance (HP:0001427)2.40794278
37Pendular nystagmus (HP:0012043)2.40552266
38Intestinal atresia (HP:0011100)2.40235729
39Increased CSF lactate (HP:0002490)2.38375398
40Severe visual impairment (HP:0001141)2.35819645
413-Methylglutaconic aciduria (HP:0003535)2.35707193
42Genital tract atresia (HP:0001827)2.34144594
43Volvulus (HP:0002580)2.30060802
44Congenital hepatic fibrosis (HP:0002612)2.29106405
45Lissencephaly (HP:0001339)2.28679704
46Postaxial foot polydactyly (HP:0001830)2.28081016
47Abnormality of the ileum (HP:0001549)2.24791474
48Cerebellar dysplasia (HP:0007033)2.24226127
49Absent/shortened dynein arms (HP:0200106)2.22386267
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.22386267
51Vaginal atresia (HP:0000148)2.19254093
52Methylmalonic acidemia (HP:0002912)2.18827046
53Tubular atrophy (HP:0000092)2.17162940
54Type I transferrin isoform profile (HP:0003642)2.16029522
55Colon cancer (HP:0003003)2.15599253
56Absent speech (HP:0001344)2.12982185
57Abnormal protein glycosylation (HP:0012346)2.09573655
58Abnormal glycosylation (HP:0012345)2.09573655
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09573655
60Abnormal protein N-linked glycosylation (HP:0012347)2.09573655
61Anencephaly (HP:0002323)2.09243216
62Decreased central vision (HP:0007663)2.08210288
63Bony spicule pigmentary retinopathy (HP:0007737)2.08207517
64Broad-based gait (HP:0002136)2.07948989
65Increased corneal curvature (HP:0100692)2.07802752
66Keratoconus (HP:0000563)2.07802752
67Tubulointerstitial abnormality (HP:0001969)2.06372967
68Sclerocornea (HP:0000647)2.05420112
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.04500828
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04258616
71Acute necrotizing encephalopathy (HP:0006965)2.03863962
72Abnormality of the labia minora (HP:0012880)2.00979380
73Acute encephalopathy (HP:0006846)2.00668522
74Abnormal respiratory epithelium morphology (HP:0012253)1.98285371
75Abnormal respiratory motile cilium morphology (HP:0005938)1.98285371
76Retinitis pigmentosa (HP:0000510)1.98171098
77Hyperglycinemia (HP:0002154)1.97295850
78Lipid accumulation in hepatocytes (HP:0006561)1.95949813
79Large for gestational age (HP:0001520)1.95779717
80Abnormal drinking behavior (HP:0030082)1.95196116
81Polydipsia (HP:0001959)1.95196116
82Progressive microcephaly (HP:0000253)1.94204770
83Occipital encephalocele (HP:0002085)1.93664526
84Hyperglycinuria (HP:0003108)1.92483401
85Optic nerve hypoplasia (HP:0000609)1.91679070
86Increased hepatocellular lipid droplets (HP:0006565)1.90626448
87Poor coordination (HP:0002370)1.89950799
88Sloping forehead (HP:0000340)1.88268052
89Renal Fanconi syndrome (HP:0001994)1.86483587
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86481997
91Abnormality of alanine metabolism (HP:0010916)1.86481997
92Hyperalaninemia (HP:0003348)1.86481997
93Clubbing of toes (HP:0100760)1.86218711
94Astigmatism (HP:0000483)1.85245196
95Meckel diverticulum (HP:0002245)1.84764258
96Polyuria (HP:0000103)1.83436897
97Increased serum lactate (HP:0002151)1.83418226
98Methylmalonic aciduria (HP:0012120)1.82784736
99Hypothermia (HP:0002045)1.81461760
100Postaxial hand polydactyly (HP:0001162)1.80642269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.72670023
2MAP4K24.38207868
3NUAK13.18762928
4ADRBK22.93991003
5WNK32.67283040
6BCKDK2.50953963
7MAP3K42.27374580
8MAPK132.19715376
9ZAK2.16046100
10INSRR2.12529271
11TAOK32.00015895
12VRK21.98575237
13BMPR1B1.96137106
14TRIM281.94396603
15PINK11.91526832
16MAP2K71.85651661
17PLK41.69065685
18CSNK1G31.62600078
19CASK1.60881845
20CSNK1A1L1.50970199
21MARK11.50359911
22NEK11.48936963
23EIF2AK31.44557859
24CSNK1G21.43935256
25PLK21.39610133
26BCR1.38827799
27WNK41.34217568
28CSNK1G11.34201755
29GRK11.19350894
30VRK11.15305998
31MKNK11.13227668
32STK38L1.05700838
33STK391.04244207
34SRPK11.03274521
35OXSR11.02857909
36CCNB11.02765850
37PRKCE0.98999523
38ADRBK10.95411645
39MKNK20.94792717
40DYRK20.94723108
41MAPKAPK50.85432975
42ACVR1B0.82691706
43PAK30.81177540
44PRKCG0.80372063
45PIK3CA0.79642373
46FLT30.79227152
47TEC0.78006516
48KIT0.77054839
49TNIK0.72193730
50PLK30.71967170
51MAPKAPK30.71748294
52BRSK20.71395658
53STK160.69061198
54FER0.68662225
55EPHA40.68616750
56ATR0.68275317
57TLK10.67803218
58NEK20.61897336
59PNCK0.61422357
60ERBB30.61368088
61TGFBR10.58236598
62CDK30.57427171
63AKT30.56984238
64LATS10.56326001
65CDK190.56116588
66PDK20.54846476
67WEE10.54267170
68TIE10.53484692
69CAMK2A0.53211595
70TXK0.50279354
71MAP2K40.49886606
72RPS6KA40.49840080
73CSNK1A10.49566169
74IRAK10.49175464
75TNK20.49135983
76PIM20.47860077
77PRKCQ0.47036923
78RPS6KA50.45535628
79PLK10.44162989
80PKN10.43485064
81PTK2B0.43056606
82ATM0.42407374
83EIF2AK10.40869888
84DYRK30.40285689
85MINK10.40083303
86CSNK1D0.39306723
87TAF10.38506713
88PRKACA0.37888898
89IKBKB0.37637316
90CAMKK20.37283619
91EPHA30.35746672
92CHEK20.35504155
93NTRK20.34845496
94ABL10.34396935
95DYRK1A0.34036549
96GRK50.33166787
97EIF2AK20.32874026
98PHKG20.31784693
99PHKG10.31784693
100STK380.29918720

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.59510066
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.15598199
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.01324689
4Butanoate metabolism_Homo sapiens_hsa006502.97369176
5Fanconi anemia pathway_Homo sapiens_hsa034602.75262524
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.57275925
7Phototransduction_Homo sapiens_hsa047442.39916796
8Homologous recombination_Homo sapiens_hsa034402.24892263
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23547776
10Propanoate metabolism_Homo sapiens_hsa006402.13313672
11Peroxisome_Homo sapiens_hsa041461.90393778
12RNA polymerase_Homo sapiens_hsa030201.89020774
13Nitrogen metabolism_Homo sapiens_hsa009101.87220478
14Protein export_Homo sapiens_hsa030601.83678591
15Basal transcription factors_Homo sapiens_hsa030221.80177420
16Non-homologous end-joining_Homo sapiens_hsa034501.76345780
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69853680
18Linoleic acid metabolism_Homo sapiens_hsa005911.67957908
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64767344
20Base excision repair_Homo sapiens_hsa034101.62654544
21Oxidative phosphorylation_Homo sapiens_hsa001901.62144054
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60676309
23Olfactory transduction_Homo sapiens_hsa047401.58103508
24Nicotine addiction_Homo sapiens_hsa050331.55426362
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51115091
26RNA degradation_Homo sapiens_hsa030181.50889202
27Taste transduction_Homo sapiens_hsa047421.46548297
28Regulation of autophagy_Homo sapiens_hsa041401.39635219
29Selenocompound metabolism_Homo sapiens_hsa004501.38876398
30Tryptophan metabolism_Homo sapiens_hsa003801.37294848
31Proteasome_Homo sapiens_hsa030501.35179497
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34829870
33Parkinsons disease_Homo sapiens_hsa050121.33914684
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.32766851
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.31468920
36Ether lipid metabolism_Homo sapiens_hsa005651.27709752
37ABC transporters_Homo sapiens_hsa020101.23935302
38Caffeine metabolism_Homo sapiens_hsa002321.10598391
39Purine metabolism_Homo sapiens_hsa002301.08421258
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06846346
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06132217
42Huntingtons disease_Homo sapiens_hsa050161.05915136
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98565579
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97205943
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96425425
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91950349
47Chemical carcinogenesis_Homo sapiens_hsa052040.89741102
48Fatty acid metabolism_Homo sapiens_hsa012120.89121471
49RNA transport_Homo sapiens_hsa030130.88819537
50Pyrimidine metabolism_Homo sapiens_hsa002400.87445403
51Metabolic pathways_Homo sapiens_hsa011000.83463083
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83126726
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83110538
54Fatty acid degradation_Homo sapiens_hsa000710.82533213
55Arachidonic acid metabolism_Homo sapiens_hsa005900.82168512
56Dorso-ventral axis formation_Homo sapiens_hsa043200.79761929
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78661349
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.78575353
59Fatty acid elongation_Homo sapiens_hsa000620.78345125
60Primary immunodeficiency_Homo sapiens_hsa053400.77705741
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.77470468
62One carbon pool by folate_Homo sapiens_hsa006700.77152705
63Nucleotide excision repair_Homo sapiens_hsa034200.76636900
64Retinol metabolism_Homo sapiens_hsa008300.76494934
65Mismatch repair_Homo sapiens_hsa034300.74501186
66Morphine addiction_Homo sapiens_hsa050320.73017380
67Asthma_Homo sapiens_hsa053100.71815431
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70793990
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69750664
70Glycerolipid metabolism_Homo sapiens_hsa005610.68536187
71Salivary secretion_Homo sapiens_hsa049700.66468637
72beta-Alanine metabolism_Homo sapiens_hsa004100.64482587
73Alzheimers disease_Homo sapiens_hsa050100.64375999
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63564844
75Circadian entrainment_Homo sapiens_hsa047130.58946196
76GABAergic synapse_Homo sapiens_hsa047270.57592700
77Glutathione metabolism_Homo sapiens_hsa004800.57435886
78Collecting duct acid secretion_Homo sapiens_hsa049660.55572254
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53966293
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51393317
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.50208641
82Oocyte meiosis_Homo sapiens_hsa041140.49290839
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.48019613
84Glutamatergic synapse_Homo sapiens_hsa047240.47909766
85Calcium signaling pathway_Homo sapiens_hsa040200.46485212
86Serotonergic synapse_Homo sapiens_hsa047260.43084311
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.42488576
88Steroid biosynthesis_Homo sapiens_hsa001000.41572582
89Ovarian steroidogenesis_Homo sapiens_hsa049130.40959222
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38817257
91Type I diabetes mellitus_Homo sapiens_hsa049400.35217427
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34934940
93Lysine degradation_Homo sapiens_hsa003100.34328129
94Sphingolipid metabolism_Homo sapiens_hsa006000.34097905
95Spliceosome_Homo sapiens_hsa030400.33356719
96Cardiac muscle contraction_Homo sapiens_hsa042600.32544830
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30962786
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30493036
99Arginine and proline metabolism_Homo sapiens_hsa003300.28323202
100Pyruvate metabolism_Homo sapiens_hsa006200.28031865

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