SPCS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.71122082
2* signal peptide processing (GO:0006465)6.56231296
3COPII vesicle coating (GO:0048208)6.55050689
4protein retention in ER lumen (GO:0006621)6.52759026
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.13039365
6sequestering of metal ion (GO:0051238)6.08410459
7protein maturation by protein folding (GO:0022417)5.74228871
8ER overload response (GO:0006983)5.60882779
9nuclear pore complex assembly (GO:0051292)5.35647003
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.84927772
11positive regulation of nuclease activity (GO:0032075)4.71675073
12vesicle coating (GO:0006901)4.69924201
13peptide hormone processing (GO:0016486)4.69144251
14nuclear pore organization (GO:0006999)4.55946398
15endocrine pancreas development (GO:0031018)4.43650541
16protein N-linked glycosylation via asparagine (GO:0018279)4.42360294
17regulation of nuclease activity (GO:0032069)4.38755347
18peptidyl-asparagine modification (GO:0018196)4.36648488
19endoplasmic reticulum unfolded protein response (GO:0030968)4.33220902
20cellular response to unfolded protein (GO:0034620)4.32085549
21peptide catabolic process (GO:0043171)4.24665246
22regulation of hexokinase activity (GO:1903299)4.21781726
23regulation of glucokinase activity (GO:0033131)4.21781726
24cellular response to topologically incorrect protein (GO:0035967)4.21173505
25protein localization to endosome (GO:0036010)4.09062578
26ER-nucleus signaling pathway (GO:0006984)4.04826460
27protein N-linked glycosylation (GO:0006487)4.02665836
28ER to Golgi vesicle-mediated transport (GO:0006888)3.95968824
29pore complex assembly (GO:0046931)3.79817086
30intra-Golgi vesicle-mediated transport (GO:0006891)3.75736146
31negative regulation of phagocytosis (GO:0050765)3.73300095
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.71425084
33type B pancreatic cell development (GO:0003323)3.70668972
34regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.62920344
35exocrine pancreas development (GO:0031017)3.58797367
36response to endoplasmic reticulum stress (GO:0034976)3.54218173
37glandular epithelial cell differentiation (GO:0002067)3.51019832
38chaperone mediated protein folding requiring cofactor (GO:0051085)3.47934190
39heart process (GO:0003015)3.47085041
40heart contraction (GO:0060047)3.47085041
41cell adhesion mediated by integrin (GO:0033627)3.46800195
42positive regulation of gamma-delta T cell activation (GO:0046645)3.37193840
43chaperone-mediated protein folding (GO:0061077)3.35594934
44GDP-mannose metabolic process (GO:0019673)3.35525977
45response to unfolded protein (GO:0006986)3.31818614
46hypotonic response (GO:0006971)3.31489221
47response to topologically incorrect protein (GO:0035966)3.22767123
48interleukin-1-mediated signaling pathway (GO:0070498)3.21534171
49inositol phosphate catabolic process (GO:0071545)3.20242539
50cell redox homeostasis (GO:0045454)3.18806714
51regulation of type B pancreatic cell apoptotic process (GO:2000674)3.16894108
52lactate metabolic process (GO:0006089)3.11956064
53glandular epithelial cell development (GO:0002068)3.06122467
54embryonic process involved in female pregnancy (GO:0060136)3.03714161
55viral protein processing (GO:0019082)3.02971210
56nucleotide-sugar biosynthetic process (GO:0009226)3.01601731
57cellular extravasation (GO:0045123)3.01587522
58dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.01476323
59folic acid-containing compound biosynthetic process (GO:0009396)2.99447023
60membrane raft organization (GO:0031579)2.98692985
61UDP-N-acetylglucosamine metabolic process (GO:0006047)2.98187797
62negative regulation of bone resorption (GO:0045779)2.96617919
63nucleotide transmembrane transport (GO:1901679)2.96557842
64insulin secretion (GO:0030073)2.95354977
65inositol phosphate dephosphorylation (GO:0046855)2.94307003
66phosphorylated carbohydrate dephosphorylation (GO:0046838)2.94307003
67production of molecular mediator involved in inflammatory response (GO:0002532)2.94054973
68misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.93949446
69positive regulation of insulin secretion (GO:0032024)2.85208844
70cellular response to antibiotic (GO:0071236)2.84204533
71regulation of fibroblast apoptotic process (GO:2000269)2.83285297
72cullin deneddylation (GO:0010388)2.83207717
73hepatocyte apoptotic process (GO:0097284)2.81539361
74mitotic sister chromatid cohesion (GO:0007064)2.79910542
75cellular response to vitamin D (GO:0071305)2.79725876
76negative regulation of fibroblast apoptotic process (GO:2000270)2.78654803
77nucleobase biosynthetic process (GO:0046112)2.78574362
78regulation of B cell receptor signaling pathway (GO:0050855)2.74257548
79cellular zinc ion homeostasis (GO:0006882)2.74246486
80hormone catabolic process (GO:0042447)2.74199326
81nucleotide-sugar metabolic process (GO:0009225)2.73691888
82regulation of vitamin D biosynthetic process (GO:0060556)2.73378578
83definitive hemopoiesis (GO:0060216)2.72285960
84protein deneddylation (GO:0000338)2.72049515
85ribosome assembly (GO:0042255)2.71462105
86regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.70961472
87positive regulation of DNA-templated transcription, initiation (GO:2000144)2.70959559
88negative regulation of glycogen biosynthetic process (GO:0045719)2.70538629
89IMP biosynthetic process (GO:0006188)2.70080419
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70055564
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69969506
92pinocytosis (GO:0006907)2.66000412
93vesicle fusion (GO:0006906)2.65334529
94peptidyl-histidine modification (GO:0018202)2.65144045
95positive regulation of T cell chemotaxis (GO:0010820)2.63915823
96regulation of T cell chemotaxis (GO:0010819)2.63915823
97fucose metabolic process (GO:0006004)2.63858243
98zinc ion homeostasis (GO:0055069)2.62750601
99antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.62394350
100regulation of transforming growth factor beta1 production (GO:0032908)2.60787432
101* regulation of insulin secretion (GO:0050796)2.60688842
102response to interleukin-15 (GO:0070672)2.60122311
103protein autoprocessing (GO:0016540)2.58206963
104iron ion import (GO:0097286)2.57841901
105wound healing, spreading of epidermal cells (GO:0035313)2.57198628
106poly(A)+ mRNA export from nucleus (GO:0016973)2.56336225
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.55228705
108maintenance of protein localization in organelle (GO:0072595)2.53020582
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52797342
110Golgi organization (GO:0007030)2.52457793
111negative regulation of DNA repair (GO:0045738)2.51242453
112eosinophil chemotaxis (GO:0048245)2.50169123
113positive regulation of endothelial cell apoptotic process (GO:2000353)2.49436419
114purine nucleobase biosynthetic process (GO:0009113)2.49380971
115Golgi vesicle transport (GO:0048193)2.48930617
116antigen processing and presentation of endogenous antigen (GO:0019883)2.48018331
117pteridine-containing compound biosynthetic process (GO:0042559)2.47942785
118nucleobase-containing small molecule interconversion (GO:0015949)2.44524595
119oxaloacetate metabolic process (GO:0006107)2.44502465
120positive regulation of keratinocyte differentiation (GO:0045618)2.43868207
121glycolipid catabolic process (GO:0019377)2.43035863
122glycosphingolipid catabolic process (GO:0046479)2.42315253
123localization within membrane (GO:0051668)2.42101169
124cellular protein complex localization (GO:0034629)2.41791385
125apoptotic cell clearance (GO:0043277)2.40985927
126neutrophil activation involved in immune response (GO:0002283)2.39928861
127negative regulation of norepinephrine secretion (GO:0010700)2.39814783
128cortical actin cytoskeleton organization (GO:0030866)2.39595764
129necroptotic process (GO:0070266)2.38860011
130reactive oxygen species biosynthetic process (GO:1903409)2.38660302
131deoxyribose phosphate biosynthetic process (GO:0046385)2.38602623
1322-deoxyribonucleotide biosynthetic process (GO:0009265)2.38602623
133* regulation of peptide hormone secretion (GO:0090276)2.38209213
134endodermal cell differentiation (GO:0035987)2.38204085
135negative regulation of anoikis (GO:2000811)2.36293588
136DNA unwinding involved in DNA replication (GO:0006268)2.35493629
137positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34712855
138valine metabolic process (GO:0006573)2.34587792
139sprouting angiogenesis (GO:0002040)2.32717090
140positive regulation of B cell differentiation (GO:0045579)2.32660200
141regulation of lymphocyte chemotaxis (GO:1901623)2.30668043
142T cell migration (GO:0072678)2.30336340
143negative regulation of interleukin-12 production (GO:0032695)2.28419508
144protein export from nucleus (GO:0006611)2.27246880
145positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.26284964
146antigen processing and presentation via MHC class Ib (GO:0002475)2.25573869
147skin morphogenesis (GO:0043589)2.24167570
148B cell receptor signaling pathway (GO:0050853)2.24122681
149hemidesmosome assembly (GO:0031581)2.21251441
150negative regulation of protein localization to plasma membrane (GO:1903077)2.21167505
151membrane protein ectodomain proteolysis (GO:0006509)2.20892885
152establishment of chromosome localization (GO:0051303)2.20574672
153protein localization to chromosome, centromeric region (GO:0071459)2.18980699
154response to laminar fluid shear stress (GO:0034616)2.18885066
155regulation of RNA export from nucleus (GO:0046831)2.18747512
156regulation of metalloenzyme activity (GO:0048552)2.18576772
157mesodermal cell differentiation (GO:0048333)2.18383469
158positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.17825696
159regulation of translational termination (GO:0006449)2.17661051
160negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.16675900
161negative regulation of cell killing (GO:0031342)2.16675900
162megakaryocyte development (GO:0035855)2.15295182
163pathway-restricted SMAD protein phosphorylation (GO:0060389)2.15215597
164response to muramyl dipeptide (GO:0032495)2.15040924
165negative T cell selection (GO:0043383)2.15031264
166regulation of B cell differentiation (GO:0045577)2.14331784
167positive regulation of protein import into nucleus, translocation (GO:0033160)2.13910611
168negative thymic T cell selection (GO:0045060)2.13498234
169hyaluronan catabolic process (GO:0030214)2.12983556
170detection of molecule of bacterial origin (GO:0032490)2.10724159
171Arp2/3 complex-mediated actin nucleation (GO:0034314)2.10461333
172positive regulation of macrophage differentiation (GO:0045651)2.10250623
173stress fiber assembly (GO:0043149)2.09374965
174non-recombinational repair (GO:0000726)2.08674707
175double-strand break repair via nonhomologous end joining (GO:0006303)2.08674707
176Rap protein signal transduction (GO:0032486)2.07961463
177osteoclast differentiation (GO:0030316)2.07356015
178chondrocyte development (GO:0002063)2.07206159
179phospholipid translocation (GO:0045332)2.04653673
180lipid translocation (GO:0034204)2.04653673
181DNA duplex unwinding (GO:0032508)2.04604207
182regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.03571593
183regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.03513346
184COPI coating of Golgi vesicle (GO:0048205)11.1590505
185Golgi transport vesicle coating (GO:0048200)11.1590505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.01468119
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.52497269
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.87291851
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.80860019
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79098704
6GATA1_22025678_ChIP-Seq_K562_Human3.59925384
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.19913557
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.17689930
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.99971241
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.92121006
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.73557912
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61875253
13ELK1_19687146_ChIP-ChIP_HELA_Human2.51731155
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.50532985
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47542668
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.45551578
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34565752
18FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.32345664
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.31031171
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.30407220
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.17861220
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.16291854
23HOXB4_20404135_ChIP-ChIP_EML_Mouse2.15194901
24AR_21909140_ChIP-Seq_LNCAP_Human2.10371158
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06778236
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04364803
27ERG_20887958_ChIP-Seq_HPC-7_Mouse2.03904396
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02534567
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99059312
30* VDR_23849224_ChIP-Seq_CD4+_Human1.96648734
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94981296
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.93075177
33* SRF_21415370_ChIP-Seq_HL-1_Mouse1.91789940
34CLOCK_20551151_ChIP-Seq_293T_Human1.88397677
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86586477
36TFEB_21752829_ChIP-Seq_HELA_Human1.81533606
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.80415976
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.80139275
39FOXP3_21729870_ChIP-Seq_TREG_Human1.76598074
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.76131591
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74668109
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71092808
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69161433
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68229598
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67443646
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.65876086
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.65804367
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64503384
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63925900
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61715121
51BRD4_25478319_ChIP-Seq_HGPS_Human1.61293926
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61157981
53MYC_22102868_ChIP-Seq_BL_Human1.60890461
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59004037
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59004037
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58155612
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54711552
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53012373
59DCP1A_22483619_ChIP-Seq_HELA_Human1.51957676
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.51054823
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50973440
62* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49561570
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48073536
64* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47076346
65RUNX_20019798_ChIP-Seq_JUKART_Human1.46967634
66GABP_19822575_ChIP-Seq_HepG2_Human1.45188903
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42680873
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39306194
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.39231667
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.37795486
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36310804
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36292148
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35736871
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33666018
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33173765
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32819682
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32183827
78* SPI1_23547873_ChIP-Seq_NB4_Human1.30734032
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29925922
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.26048710
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25922468
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24908250
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23095241
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22594240
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.20051762
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20013346
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19450949
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19445186
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18010634
90MYB_26560356_Chip-Seq_TH2_Human1.16979951
91* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16310627
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16027632
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13652335
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12481562
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.12174743
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11565412
97MAF_26560356_Chip-Seq_TH1_Human1.11365237
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10920856
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10792067
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10276351
101* GATA3_26560356_Chip-Seq_TH2_Human1.10135816
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09829656
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09323267
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09102741
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08193786
106* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07419329
107* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05453125
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05138196
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.04886561
110CIITA_25753668_ChIP-Seq_RAJI_Human1.04850200
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04243334
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03901881
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02705987
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02527316
115FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01240384
116SCL_19346495_ChIP-Seq_HPC-7_Human1.00504420
117SPI1_23127762_ChIP-Seq_K562_Human0.99357326
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.98169909
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96767084
120VDR_24787735_ChIP-Seq_THP-1_Human0.95384658
121IRF8_27001747_Chip-Seq_BMDM_Mouse0.95265105
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95085011
123PU_27001747_Chip-Seq_BMDM_Mouse0.92310820
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92270957
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92269087
126MYB_26560356_Chip-Seq_TH1_Human0.92233133
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89990968
128* GATA3_27048872_Chip-Seq_THYMUS_Human0.89376148
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89301234
130VDR_24763502_ChIP-Seq_THP-1_Human0.88147616
131* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87721019
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87612716
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87503245
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86924340
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86610494
136* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85800602
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85544942
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85219791
139STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84697810
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84650861
141FLI1_27457419_Chip-Seq_LIVER_Mouse0.84613741
142* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84580792
143* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84580792
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83427510
145TCF7_22412390_ChIP-Seq_EML_Mouse0.83296870
146CHD1_26751641_Chip-Seq_LNCaP_Human0.82872958
147* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82655026
148TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82044655
149GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80600798
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79532795
151KDM5A_27292631_Chip-Seq_BREAST_Human0.78807644
152AR_20517297_ChIP-Seq_VCAP_Human0.78282147
153* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77991270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog6.03729453
2MP0000678_abnormal_parathyroid_gland3.32657038
3MP0002693_abnormal_pancreas_physiology3.24681061
4MP0009780_abnormal_chondrocyte_physiolo3.19732402
5MP0003183_abnormal_peptide_metabolism3.17089517
6MP0003195_calcinosis3.03936952
7MP0001944_abnormal_pancreas_morphology2.67732201
8MP0006054_spinal_hemorrhage2.63389540
9MP0010386_abnormal_urinary_bladder2.62615275
10MP0003705_abnormal_hypodermis_morpholog2.59597526
11MP0004264_abnormal_extraembryonic_tissu2.55537071
12MP0004043_abnormal_pH_regulation2.50551202
13MP0000013_abnormal_adipose_tissue2.48193028
14MP0003566_abnormal_cell_adhesion2.42952437
15MP0005220_abnormal_exocrine_pancreas2.39874510
16MP0010234_abnormal_vibrissa_follicle2.28935376
17MP0005379_endocrine/exocrine_gland_phen2.15231798
18MP0002837_dystrophic_cardiac_calcinosis2.07722277
19MP0005646_abnormal_pituitary_gland1.97651652
20MP0004272_abnormal_basement_membrane1.97086671
21MP0002876_abnormal_thyroid_physiology1.94182932
22MP0003300_gastrointestinal_ulcer1.82796842
23MP0009697_abnormal_copulation1.81351121
24MP0003693_abnormal_embryo_hatching1.79677036
25MP0004782_abnormal_surfactant_physiolog1.78710094
26MP0003828_pulmonary_edema1.75212205
27MP0001986_abnormal_taste_sensitivity1.73763708
28MP0005275_abnormal_skin_tensile1.72195532
29MP0002909_abnormal_adrenal_gland1.69093652
30MP0005365_abnormal_bile_salt1.67046105
31MP0001835_abnormal_antigen_presentation1.65433200
32MP0003091_abnormal_cell_migration1.61945173
33MP0003279_aneurysm1.60074872
34MP0002928_abnormal_bile_duct1.58752609
35MP0002078_abnormal_glucose_homeostasis1.55133637
36MP0003172_abnormal_lysosome_physiology1.50893145
37MP0003303_peritoneal_inflammation1.50781859
38MP0000681_abnormal_thyroid_gland1.50630919
39MP0005408_hypopigmentation1.49106208
40MP0000569_abnormal_digit_pigmentation1.47799625
41MP0003191_abnormal_cellular_cholesterol1.46623278
42MP0008057_abnormal_DNA_replication1.45550167
43MP0001958_emphysema1.44383872
44MP0003448_altered_tumor_morphology1.43689907
45MP0001764_abnormal_homeostasis1.43213654
46MP0005310_abnormal_salivary_gland1.41793769
47MP0002139_abnormal_hepatobiliary_system1.40572590
48MP0002060_abnormal_skin_morphology1.40521471
49MP0000685_abnormal_immune_system1.39755569
50MP0002009_preneoplasia1.38528631
51MP0003950_abnormal_plasma_membrane1.36729268
52MP0005058_abnormal_lysosome_morphology1.36064923
53MP0000465_gastrointestinal_hemorrhage1.35849047
54MP0003943_abnormal_hepatobiliary_system1.34031663
55MP0008007_abnormal_cellular_replicative1.33133385
56MP0001915_intracranial_hemorrhage1.30074568
57MP0005084_abnormal_gallbladder_morpholo1.29637155
58MP0000015_abnormal_ear_pigmentation1.28935474
59MP0003806_abnormal_nucleotide_metabolis1.26944976
60MP0004947_skin_inflammation1.25942073
61MP0005076_abnormal_cell_differentiation1.23640259
62MP0003724_increased_susceptibility_to1.23475996
63MP0005671_abnormal_response_to1.22180467
64MP0008260_abnormal_autophagy1.21578777
65MP0001853_heart_inflammation1.21543612
66MP0002896_abnormal_bone_mineralization1.20911611
67MP0006082_CNS_inflammation1.20224010
68MP0001800_abnormal_humoral_immune1.19697861
69MP0002398_abnormal_bone_marrow1.18609795
70MP0010155_abnormal_intestine_physiology1.18158592
71MP0003656_abnormal_erythrocyte_physiolo1.16463311
72MP0008058_abnormal_DNA_repair1.15426328
73MP0005451_abnormal_body_composition1.14913755
74MP0002148_abnormal_hypersensitivity_rea1.14827258
75MP0003111_abnormal_nucleus_morphology1.14284927
76MP0002405_respiratory_system_inflammati1.13897612
77MP0002166_altered_tumor_susceptibility1.13812669
78MP0003221_abnormal_cardiomyocyte_apopto1.13686598
79MP0005023_abnormal_wound_healing1.13133476
80MP0001666_abnormal_nutrient_absorption1.09793878
81MP0002723_abnormal_immune_serum1.08805523
82MP0003795_abnormal_bone_structure1.08546297
83MP0000003_abnormal_adipose_tissue1.06421756
84MP0003787_abnormal_imprinting1.05642157
85MP0000703_abnormal_thymus_morphology1.04301884
86MP0002396_abnormal_hematopoietic_system1.04222508
87MP0005636_abnormal_mineral_homeostasis1.04156767
88MP0002086_abnormal_extraembryonic_tissu1.04021422
89MP0008438_abnormal_cutaneous_collagen1.03559333
90MP0002998_abnormal_bone_remodeling1.03555644
91MP0002722_abnormal_immune_system1.03017169
92MP0001186_pigmentation_phenotype1.02780646
93MP0002138_abnormal_hepatobiliary_system1.02587408
94MP0003122_maternal_imprinting1.02175325
95MP0003283_abnormal_digestive_organ1.01653308
96MP0001851_eye_inflammation1.01006196
97MP0003252_abnormal_bile_duct1.00634459
98MP0009785_altered_susceptibility_to1.00189890
99MP0002419_abnormal_innate_immunity0.99742548
100MP0005621_abnormal_cell_physiology0.99440323
101MP0003077_abnormal_cell_cycle0.99043057
102MP0002163_abnormal_gland_morphology0.98373988
103MP0000350_abnormal_cell_proliferation0.98228527
104MP0005000_abnormal_immune_tolerance0.97672997
105MP0000689_abnormal_spleen_morphology0.96332998
106MP0000716_abnormal_immune_system0.95886088
107MP0001730_embryonic_growth_arrest0.94732655
108MP0003941_abnormal_skin_development0.94181224
109MP0003453_abnormal_keratinocyte_physiol0.93441446
110MP0001919_abnormal_reproductive_system0.92774852
111MP0000767_abnormal_smooth_muscle0.92476237
112MP0003868_abnormal_feces_composition0.92421149
113MP0002429_abnormal_blood_cell0.92308226
114MP0003186_abnormal_redox_activity0.90938398
115MP0005387_immune_system_phenotype0.90882061
116MP0001790_abnormal_immune_system0.90882061
117MP0005623_abnormal_meninges_morphology0.90628084
118MP0004957_abnormal_blastocyst_morpholog0.90409321
119MP0005165_increased_susceptibility_to0.89954356
120MP0009643_abnormal_urine_homeostasis0.89730521
121MP0010352_gastrointestinal_tract_polyps0.89366482
122MP0003984_embryonic_growth_retardation0.88171557
123MP0001845_abnormal_inflammatory_respons0.88096557
124MP0001765_abnormal_ion_homeostasis0.87816076
125MP0001533_abnormal_skeleton_physiology0.87087093
126MP0001243_abnormal_dermal_layer0.87080213
127MP0003436_decreased_susceptibility_to0.86785071
128MP0010368_abnormal_lymphatic_system0.86652692
129MP0005389_reproductive_system_phenotype0.85841292
130MP0002088_abnormal_embryonic_growth/wei0.85540421
131MP0005645_abnormal_hypothalamus_physiol0.84189360
132MP0003953_abnormal_hormone_level0.82780900
133MP0010094_abnormal_chromosome_stability0.82648655
134MP0005380_embryogenesis_phenotype0.82327978
135MP0001672_abnormal_embryogenesis/_devel0.82327978
136MP0004808_abnormal_hematopoietic_stem0.80766900
137MP0009333_abnormal_splenocyte_physiolog0.79354463
138MP0005164_abnormal_response_to0.79187612
139MP0000613_abnormal_salivary_gland0.77620932
140MP0000490_abnormal_crypts_of0.77107306
141MP0001661_extended_life_span0.77071087
142MP0001216_abnormal_epidermal_layer0.76603976
143MP0000858_altered_metastatic_potential0.76142568
144MP0001756_abnormal_urination0.75846421
145MP0010307_abnormal_tumor_latency0.75834322
146MP0000371_diluted_coat_color0.75090949
147MP0002006_tumorigenesis0.74694026
148MP0002933_joint_inflammation0.74479462
149MP0003123_paternal_imprinting0.74046907
150MP0003866_abnormal_defecation0.73651306
151MP0002420_abnormal_adaptive_immunity0.72390672
152MP0002095_abnormal_skin_pigmentation0.72335676
153MP0001819_abnormal_immune_cell0.70683294
154MP0003763_abnormal_thymus_physiology0.69811418
155MP0005464_abnormal_platelet_physiology0.68280186
156MP0005085_abnormal_gallbladder_physiolo0.67614254
157MP0000372_irregular_coat_pigmentation0.67202455
158MP0003121_genomic_imprinting0.64919779
159MP0002452_abnormal_antigen_presenting0.63591868
160MP0000598_abnormal_liver_morphology0.63338868
161MP0005025_abnormal_response_to0.63038938

Predicted human phenotypes

RankGene SetZ-score
1Symptomatic seizures (HP:0011145)5.58726669
2Hypoglycemic seizures (HP:0002173)5.29195366
3Hyperinsulinemic hypoglycemia (HP:0000825)5.04221324
4Hypoglycemic coma (HP:0001325)4.78537270
5Generalized aminoaciduria (HP:0002909)4.74553752
6Abnormality of the intrinsic pathway (HP:0010989)4.38942972
7Type I transferrin isoform profile (HP:0003642)4.31012220
8Premature rupture of membranes (HP:0001788)4.03822751
9Abnormal protein N-linked glycosylation (HP:0012347)3.97245046
10Abnormal protein glycosylation (HP:0012346)3.97245046
11Abnormal glycosylation (HP:0012345)3.97245046
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.97245046
13Pancreatic islet-cell hyperplasia (HP:0004510)3.94817908
14Abnormality of the pancreatic islet cells (HP:0006476)3.90204261
15Abnormality of endocrine pancreas physiology (HP:0012093)3.90204261
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.89977171
17Ankyloglossia (HP:0010296)3.61279372
18Hyperglycemia (HP:0003074)3.58859009
19Abnormality of oral frenula (HP:0000190)3.57832624
20Osteolytic defects of the phalanges of the hand (HP:0009771)3.34251597
21Osteolytic defects of the hand bones (HP:0009699)3.34251597
22Thrombocytosis (HP:0001894)3.28401307
23T lymphocytopenia (HP:0005403)3.24734691
24Insulin-resistant diabetes mellitus (HP:0000831)3.19930849
25Aortic dissection (HP:0002647)3.16674399
26Abnormal pancreas size (HP:0012094)3.10325748
27Abnormality of T cell number (HP:0011839)3.06559737
28Syringomyelia (HP:0003396)3.05349005
29Spinal cord lesions (HP:0100561)3.05349005
30Reduced antithrombin III activity (HP:0001976)3.02624362
31Conjugated hyperbilirubinemia (HP:0002908)3.00376884
32Prominent metopic ridge (HP:0005487)3.00222389
33Arterial tortuosity (HP:0005116)2.93027769
34Eczematoid dermatitis (HP:0000976)2.90631701
35Dilatation of the ascending aorta (HP:0005111)2.89044285
36Degeneration of anterior horn cells (HP:0002398)2.82888961
37Abnormality of the anterior horn cell (HP:0006802)2.82888961
38Vacuolated lymphocytes (HP:0001922)2.81266668
39Vascular tortuosity (HP:0004948)2.77522717
40Protrusio acetabuli (HP:0003179)2.76776620
41Abnormality of the common coagulation pathway (HP:0010990)2.70267654
42Papilledema (HP:0001085)2.69363095
43Urinary glycosaminoglycan excretion (HP:0003541)2.68252031
44Mucopolysacchariduria (HP:0008155)2.68252031
45Spontaneous hematomas (HP:0007420)2.61046821
46Nonimmune hydrops fetalis (HP:0001790)2.60798978
47Hypothermia (HP:0002045)2.59548381
4811 pairs of ribs (HP:0000878)2.56598291
49Aortic aneurysm (HP:0004942)2.55115119
50Decreased circulating renin level (HP:0003351)2.54086594
51Abnormality of the metopic suture (HP:0005556)2.52908032
52Limb hypertonia (HP:0002509)2.49059527
53Cervical subluxation (HP:0003308)2.47320846
54Recurrent viral infections (HP:0004429)2.46683618
55Spondylolisthesis (HP:0003302)2.45690769
56Autoimmune hemolytic anemia (HP:0001890)2.45475982
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.42581663
58Asymmetry of the thorax (HP:0001555)2.41389848
59Atrophic scars (HP:0001075)2.39944351
60Late onset (HP:0003584)2.36268441
61Ketoacidosis (HP:0001993)2.36005513
62Subacute progressive viral hepatitis (HP:0006572)2.35520023
63Recurrent bacterial skin infections (HP:0005406)2.35326095
64Recurrent abscess formation (HP:0002722)2.34211645
65Neoplasm of the adrenal gland (HP:0100631)2.33186309
66Periodontitis (HP:0000704)2.32860476
67Acute myeloid leukemia (HP:0004808)2.32557144
68Hematochezia (HP:0002573)2.31443201
69Myocardial infarction (HP:0001658)2.31388749
70Mitral valve prolapse (HP:0001634)2.31111377
71Hypoplasia of the thymus (HP:0000778)2.27151980
72Beaking of vertebral bodies (HP:0004568)2.26294089
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22451055
74Abnormality of polysaccharide metabolism (HP:0011012)2.22451055
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22451055
76Abnormality of subcutaneous fat tissue (HP:0001001)2.20980950
77Abnormal biliary tract morphology (HP:0012440)2.19706083
78Abnormality of T cell physiology (HP:0011840)2.19614652
79Dysostosis multiplex (HP:0000943)2.18628667
80Orthostatic hypotension (HP:0001278)2.18284260
81Broad face (HP:0000283)2.17284251
82Papillary thyroid carcinoma (HP:0002895)2.16325766
83Osteomalacia (HP:0002749)2.14301570
84Tetraparesis (HP:0002273)2.14121736
85Disproportionate short-trunk short stature (HP:0003521)2.12189324
86Aplastic anemia (HP:0001915)2.08575375
87Wormian bones (HP:0002645)2.07607375
88Cerebral aneurysm (HP:0004944)2.07307690
89Hypoplasia of the fovea (HP:0007750)2.06129001
90Aplasia/Hypoplasia of the fovea (HP:0008060)2.06129001
91Curly hair (HP:0002212)2.05194989
92Large for gestational age (HP:0001520)2.04109443
93Relative macrocephaly (HP:0004482)2.02142475
94Hypoplasia of the pons (HP:0012110)2.01960774
95Abnormality of the vasculature of the conjunctiva (HP:0008054)2.01922346
96Abnormality of macrophages (HP:0004311)2.01732564
97Hypokalemia (HP:0002900)2.01270788
98Abnormality of T cells (HP:0002843)2.01099006
99Fatigue (HP:0012378)2.00824173
100Short middle phalanx of the 5th finger (HP:0004220)1.99646119
101Abnormal platelet volume (HP:0011876)1.99240107
102Epiphyseal stippling (HP:0010655)1.99003651
103Osteomyelitis (HP:0002754)1.98402573
104Spinal muscular atrophy (HP:0007269)1.98389267
105Chronic diarrhea (HP:0002028)1.98259990
106Thoracolumbar scoliosis (HP:0002944)1.98109029
107Pancreatic fibrosis (HP:0100732)1.95049775
108Abnormal delayed hypersensitivity skin test (HP:0002963)1.94995949
109Dysautonomia (HP:0002459)1.94551623
110Abnormal foot bone ossification (HP:0010675)1.93993650
111Increased mean platelet volume (HP:0011877)1.93032810
112Chronic mucocutaneous candidiasis (HP:0002728)1.92860979
113Recurrent cutaneous fungal infections (HP:0011370)1.92860979
114Delayed closure of the anterior fontanelle (HP:0001476)1.92568092
115Insulin resistance (HP:0000855)1.92172914
116Mucosal telangiectasiae (HP:0100579)1.91944379
117Gingivitis (HP:0000230)1.91924927
118Abnormality of the pons (HP:0007361)1.90884527
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90002799
120Poor head control (HP:0002421)1.88270047
121Renal cortical cysts (HP:0000803)1.87939078
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.87354517
123Conjunctival telangiectasia (HP:0000524)1.85262597
124Protuberant abdomen (HP:0001538)1.84335409
125Thyroid carcinoma (HP:0002890)1.84028464
126IgA deficiency (HP:0002720)1.82343991
127Fat malabsorption (HP:0002630)1.81173709
128Cellulitis (HP:0100658)1.80937896
129Recurrent fungal infections (HP:0002841)1.80693841
130Insidious onset (HP:0003587)1.78356278
131Termporal pattern (HP:0011008)1.78356278
132Viral hepatitis (HP:0006562)1.78120723
133Soft skin (HP:0000977)1.77986022
134Acute hepatic failure (HP:0006554)1.76144678
135Blue sclerae (HP:0000592)1.76131064
136Glycosuria (HP:0003076)1.75430820
137Abnormality of urine glucose concentration (HP:0011016)1.75430820
138Elevated alkaline phosphatase (HP:0003155)1.74851173
139Abnormal epiphyseal ossification (HP:0010656)1.73314918
140Abnormality of liposaccharide metabolism (HP:0010968)1.73139635
141Abnormality of glycosphingolipid metabolism (HP:0004343)1.73139635
142Abnormality of glycolipid metabolism (HP:0010969)1.73139635
143Fragile skin (HP:0001030)1.72502613
144Hyperbilirubinemia (HP:0002904)1.72250643
145Recurrent skin infections (HP:0001581)1.72047803
146Peritonitis (HP:0002586)1.71002757
147Thick nail (HP:0001805)1.70872244
148Deep philtrum (HP:0002002)1.70756449
149Neoplasm of the adrenal cortex (HP:0100641)1.69988168
150Transitional cell carcinoma of the bladder (HP:0006740)1.69254481
151Alveolar cell carcinoma (HP:0006519)1.68928995
152Disproportionate tall stature (HP:0001519)1.68910526
153Abnormality of the fovea (HP:0000493)1.68490408
154Exocrine pancreatic insufficiency (HP:0001738)1.68479489
155Aneurysm (HP:0002617)1.68216391
156Severe short stature (HP:0003510)1.67988024
157Vertebral compression fractures (HP:0002953)1.67478376
158Bladder carcinoma (HP:0002862)1.67263687
159Bladder neoplasm (HP:0009725)1.67263687
160Cutaneous melanoma (HP:0012056)1.66304718
161Progressive sensorineural hearing impairment (HP:0000408)1.64816229
162Absent frontal sinuses (HP:0002688)1.64491953
163Persistence of primary teeth (HP:0006335)1.64361847
164Coarse hair (HP:0002208)1.64323489
165Autoimmune thrombocytopenia (HP:0001973)1.63639558
166Polycythemia (HP:0001901)1.62893570
167Amaurosis fugax (HP:0100576)1.61980181
168Cystic liver disease (HP:0006706)1.61960646
169Thickened calvaria (HP:0002684)1.61759814
170Arterial thrombosis (HP:0004420)1.61194732
171Spastic diplegia (HP:0001264)1.61143574
172Recurrent gram-negative bacterial infections (HP:0005420)1.59881032
173Progressive neurologic deterioration (HP:0002344)1.58096306
174IgM deficiency (HP:0002850)1.57879854
175Hypoplasia of the odontoid process (HP:0003311)1.56891646
176Thin bony cortex (HP:0002753)1.56676116
177Abnormality of alkaline phosphatase activity (HP:0004379)1.56401254
178Ankle contracture (HP:0006466)1.55366317
179Overgrowth (HP:0001548)1.54577359
180Selective tooth agenesis (HP:0001592)1.54313241
181Reduced subcutaneous adipose tissue (HP:0003758)1.53920415
182Upper motor neuron abnormality (HP:0002127)1.53706198
183Gastrointestinal carcinoma (HP:0002672)1.53568497
184Malignant gastrointestinal tract tumors (HP:0006749)1.53568497
185Steatorrhea (HP:0002570)1.51287058
186True hermaphroditism (HP:0010459)1.51089633
187Neoplasm of the thyroid gland (HP:0100031)1.50871740
188Proximal tubulopathy (HP:0000114)1.50828560
189Decreased subcutaneous fat (HP:0001002)1.50660542
190Glucose intolerance (HP:0000833)1.49598307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.39684018
2FRK4.07373223
3PASK3.84360774
4AKT33.41671684
5IRAK32.85142397
6CCNB12.76501291
7TAOK32.63289350
8BRSK22.47444478
9ERBB32.42526233
10ZAK2.35620493
11EIF2AK32.27021179
12NEK92.13196863
13PRKD32.11708179
14IRAK41.99527808
15MAP3K141.99452517
16TGFBR21.97320093
17TSSK61.95506018
18CDK61.88317306
19PDGFRA1.88294116
20TYK21.83264239
21MAP3K101.82232514
22FLT31.78430860
23BMPR21.77306138
24SIK31.72188276
25CASK1.71833758
26TEC1.55783156
27EEF2K1.54458247
28TXK1.48589454
29TRPM71.45758378
30NEK11.41504397
31TTN1.40133803
32JAK31.38659238
33STK101.33398227
34CDK121.28360196
35PAK41.26770334
36KSR21.25122368
37BCKDK1.20631984
38RPS6KB11.19739875
39CSK1.19738482
40MAP3K131.18294436
41PKN21.17893894
42ZAP701.17712862
43MKNK21.17598307
44BRSK11.17360342
45RIPK41.17320550
46HIPK21.17004161
47ERN11.16168070
48MAP3K31.15605656
49CAMKK21.15135824
50STK38L1.14918609
51PIK3CA1.14835436
52TIE11.12372831
53NUAK11.11993063
54STK241.09020978
55EIF2AK11.06258917
56SRPK11.05676803
57MAP3K21.03932639
58BRD41.03157881
59SGK21.02496518
60PLK31.01615512
61LATS21.00599284
62PAK20.99756683
63FGFR40.99432654
64MAPK150.99174625
65SCYL20.99045938
66BTK0.97249733
67TTK0.96651300
68VRK10.96235613
69MELK0.95536726
70PLK40.95207683
71PLK20.94562924
72CDK80.94018598
73RPS6KA20.93749450
74PDGFRB0.91843486
75MAP3K80.91023538
76STK160.90076302
77KSR10.87738489
78FES0.87450347
79PIK3CG0.87057708
80BRAF0.86539994
81BLK0.86132582
82TGFBR10.84811375
83HCK0.83156982
84RAF10.82730290
85ALK0.81691608
86ACVR1B0.80995006
87ITK0.79761410
88TESK10.77336030
89DAPK10.76011688
90CDC42BPA0.75706865
91BUB10.75506904
92STK40.74002693
93FGR0.73917530
94WEE10.71481105
95MAP2K30.71371553
96MOS0.69258786
97JAK10.67450006
98CDK40.67094083
99NTRK10.64278623
100FGFR10.61817898
101RPS6KB20.60694018
102NEK60.60619486
103ERBB40.60219492
104ATR0.58133917
105LCK0.57624216
106MAP3K60.57597855
107TAF10.56058105
108CHUK0.55514926
109RPS6KA40.53966988
110RPS6KC10.53691689
111RPS6KL10.53691689
112KDR0.53028415
113MYLK0.52435413
114RET0.51293227
115PIM20.50985938
116RPS6KA60.50780425
117PTK20.50341647
118PRKCH0.48662247
119MST1R0.48533432
120SMG10.47775602
121BCR0.46969250
122FGFR30.46148658
123SGK30.45883226
124SYK0.44697330
125CLK10.43863997
126STK30.41779209
127IRAK10.41425301
128MKNK10.41292132
129MAP3K50.40395455
130JAK20.38762104
131MAPKAPK30.37024837
132PIM10.36887573
133TAOK20.36857952
134PRPF4B0.35648351
135ATM0.35092819
136YES10.33816700
137CSNK2A10.33731352
138NME20.33568191
139LYN0.32573731
140MAP4K10.32110044
141MAP2K70.31932893
142EIF2AK20.31188693
143IKBKB0.30588953
144MAP3K10.29407019
145MAPK30.27297982
146MST40.25288660
147BMPR1B0.25183604
148IGF1R0.24051311
149PRKCE0.23254556
150MAPKAPK20.23139162
151CDC70.22715898
152LATS10.21530839
153CSNK1A10.21116010

Predicted pathways (KEGG)

RankGene SetZ-score
1* Protein export_Homo sapiens_hsa030606.59069610
2Maturity onset diabetes of the young_Homo sapiens_hsa049506.58245173
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.92660350
4Sulfur metabolism_Homo sapiens_hsa009203.46417181
5N-Glycan biosynthesis_Homo sapiens_hsa005102.82448974
6SNARE interactions in vesicular transport_Homo sapiens_hsa041301.98237000
7Type I diabetes mellitus_Homo sapiens_hsa049401.96989757
8Vibrio cholerae infection_Homo sapiens_hsa051101.96355652
9Chronic myeloid leukemia_Homo sapiens_hsa052201.95400187
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91751143
11Other glycan degradation_Homo sapiens_hsa005111.88042284
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.84958148
13Galactose metabolism_Homo sapiens_hsa000521.83961214
14Pancreatic cancer_Homo sapiens_hsa052121.82897628
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79490554
16Selenocompound metabolism_Homo sapiens_hsa004501.70919345
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.69691644
18Antigen processing and presentation_Homo sapiens_hsa046121.69635072
19Legionellosis_Homo sapiens_hsa051341.67331702
20Small cell lung cancer_Homo sapiens_hsa052221.65287348
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63910990
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63783549
23Non-small cell lung cancer_Homo sapiens_hsa052231.63619023
24B cell receptor signaling pathway_Homo sapiens_hsa046621.61942337
25DNA replication_Homo sapiens_hsa030301.61393634
26Mismatch repair_Homo sapiens_hsa034301.55222735
27One carbon pool by folate_Homo sapiens_hsa006701.54147640
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53942228
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.52508845
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50561365
31Insulin secretion_Homo sapiens_hsa049111.49512265
32Osteoclast differentiation_Homo sapiens_hsa043801.48790333
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42101911
34Shigellosis_Homo sapiens_hsa051311.41886804
35Renal cell carcinoma_Homo sapiens_hsa052111.39444298
36T cell receptor signaling pathway_Homo sapiens_hsa046601.38204162
37Proteoglycans in cancer_Homo sapiens_hsa052051.37476666
38Focal adhesion_Homo sapiens_hsa045101.35859431
39Acute myeloid leukemia_Homo sapiens_hsa052211.35473038
40Non-homologous end-joining_Homo sapiens_hsa034501.31479809
41Lysosome_Homo sapiens_hsa041421.30227225
42Malaria_Homo sapiens_hsa051441.28835141
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.27926902
44Base excision repair_Homo sapiens_hsa034101.23530537
45MicroRNAs in cancer_Homo sapiens_hsa052061.22097339
46Colorectal cancer_Homo sapiens_hsa052101.22053751
47Bladder cancer_Homo sapiens_hsa052191.16201994
48Adherens junction_Homo sapiens_hsa045201.13654068
49TNF signaling pathway_Homo sapiens_hsa046681.11518138
50Amoebiasis_Homo sapiens_hsa051461.11476776
51ECM-receptor interaction_Homo sapiens_hsa045121.10454481
52Viral myocarditis_Homo sapiens_hsa054161.09647980
53Endometrial cancer_Homo sapiens_hsa052131.08416429
54Phagosome_Homo sapiens_hsa041451.06929276
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06834709
56Platelet activation_Homo sapiens_hsa046111.04258356
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.04222405
58Proteasome_Homo sapiens_hsa030501.03083616
59Starch and sucrose metabolism_Homo sapiens_hsa005001.02892351
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02041071
61Fructose and mannose metabolism_Homo sapiens_hsa000511.00040740
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96675873
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.95107680
64HIF-1 signaling pathway_Homo sapiens_hsa040660.94920062
65Folate biosynthesis_Homo sapiens_hsa007900.94338620
66Salmonella infection_Homo sapiens_hsa051320.94145042
67Glioma_Homo sapiens_hsa052140.93630560
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92429456
69Graft-versus-host disease_Homo sapiens_hsa053320.90576280
70RNA degradation_Homo sapiens_hsa030180.88448665
71mTOR signaling pathway_Homo sapiens_hsa041500.88276004
72Homologous recombination_Homo sapiens_hsa034400.87321958
73Autoimmune thyroid disease_Homo sapiens_hsa053200.86786056
74Pyrimidine metabolism_Homo sapiens_hsa002400.85711108
75Chemokine signaling pathway_Homo sapiens_hsa040620.85122360
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.84005070
77VEGF signaling pathway_Homo sapiens_hsa043700.83470199
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81737742
79Type II diabetes mellitus_Homo sapiens_hsa049300.79849957
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.79666249
81Leishmaniasis_Homo sapiens_hsa051400.78902101
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78627287
83Hepatitis C_Homo sapiens_hsa051600.75843716
84Primary immunodeficiency_Homo sapiens_hsa053400.75799317
85Thyroid hormone synthesis_Homo sapiens_hsa049180.74804459
86Cell cycle_Homo sapiens_hsa041100.72175475
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.70386123
88Pathways in cancer_Homo sapiens_hsa052000.67298319
89Inositol phosphate metabolism_Homo sapiens_hsa005620.67282849
90Nucleotide excision repair_Homo sapiens_hsa034200.67065637
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.66429097
92Regulation of autophagy_Homo sapiens_hsa041400.65604531
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63962457
94Pertussis_Homo sapiens_hsa051330.62429892
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61493599
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61422792
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59516190
98Thyroid cancer_Homo sapiens_hsa052160.59328509
99Tryptophan metabolism_Homo sapiens_hsa003800.58740070
100Measles_Homo sapiens_hsa051620.58524219
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58514289
102Renin-angiotensin system_Homo sapiens_hsa046140.57753601
103TGF-beta signaling pathway_Homo sapiens_hsa043500.57619189
104Systemic lupus erythematosus_Homo sapiens_hsa053220.57471478
105Purine metabolism_Homo sapiens_hsa002300.57431417
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55067423
107mRNA surveillance pathway_Homo sapiens_hsa030150.54688806
108RNA polymerase_Homo sapiens_hsa030200.54688335
109Insulin resistance_Homo sapiens_hsa049310.54187201
110Collecting duct acid secretion_Homo sapiens_hsa049660.54159371
111Dorso-ventral axis formation_Homo sapiens_hsa043200.53386358
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52747863
113RNA transport_Homo sapiens_hsa030130.52367686
114ErbB signaling pathway_Homo sapiens_hsa040120.51836571
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50518394
116Sphingolipid metabolism_Homo sapiens_hsa006000.47289463
117Asthma_Homo sapiens_hsa053100.46846630
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45173251
119Rheumatoid arthritis_Homo sapiens_hsa053230.44343631
120Epstein-Barr virus infection_Homo sapiens_hsa051690.43663253
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42648270
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41600171
123Viral carcinogenesis_Homo sapiens_hsa052030.41484030
124Glucagon signaling pathway_Homo sapiens_hsa049220.41107606
125ABC transporters_Homo sapiens_hsa020100.40479733
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37676030
127Herpes simplex infection_Homo sapiens_hsa051680.37311611
128Influenza A_Homo sapiens_hsa051640.36742203
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36733271
130Prolactin signaling pathway_Homo sapiens_hsa049170.36512910
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35874537
132Tuberculosis_Homo sapiens_hsa051520.35604961
133Hematopoietic cell lineage_Homo sapiens_hsa046400.35524120
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31818191
135Peroxisome_Homo sapiens_hsa041460.31615193
136Fanconi anemia pathway_Homo sapiens_hsa034600.31171027
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.30972258
138Hepatitis B_Homo sapiens_hsa051610.28950813
139Phenylalanine metabolism_Homo sapiens_hsa003600.28825219
140Allograft rejection_Homo sapiens_hsa053300.28526395
141Prostate cancer_Homo sapiens_hsa052150.28241669
142Spliceosome_Homo sapiens_hsa030400.25607847
143p53 signaling pathway_Homo sapiens_hsa041150.25566586
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24199945
145Pancreatic secretion_Homo sapiens_hsa049720.21646908
146Arachidonic acid metabolism_Homo sapiens_hsa005900.21559160
147Circadian rhythm_Homo sapiens_hsa047100.21513785
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20820022
149Apoptosis_Homo sapiens_hsa042100.20327074
150Cocaine addiction_Homo sapiens_hsa050300.19393791
151Metabolic pathways_Homo sapiens_hsa011000.19125051
152Toxoplasmosis_Homo sapiens_hsa051450.18614805
153Basal transcription factors_Homo sapiens_hsa030220.14626640
154FoxO signaling pathway_Homo sapiens_hsa040680.14132414
155HTLV-I infection_Homo sapiens_hsa051660.12378043

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »