SPC25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.70830780
2Golgi transport vesicle coating (GO:0048200)5.70830780
3mitotic metaphase plate congression (GO:0007080)5.25844538
4protein localization to kinetochore (GO:0034501)5.22776517
5CENP-A containing nucleosome assembly (GO:0034080)5.20115678
6chromatin remodeling at centromere (GO:0031055)5.07122249
7kinetochore organization (GO:0051383)5.04552614
8mitotic chromosome condensation (GO:0007076)4.93167867
9attachment of spindle microtubules to kinetochore (GO:0008608)4.91304844
10metaphase plate congression (GO:0051310)4.76820231
11protein localization to chromosome, centromeric region (GO:0071459)4.72370594
12behavioral response to nicotine (GO:0035095)4.65832249
13mitotic sister chromatid segregation (GO:0000070)4.65748041
14DNA replication-independent nucleosome assembly (GO:0006336)4.58797697
15DNA replication-independent nucleosome organization (GO:0034724)4.58797697
16kinetochore assembly (GO:0051382)4.52394101
17telomere maintenance via semi-conservative replication (GO:0032201)4.47083620
18establishment of chromosome localization (GO:0051303)4.43042207
19DNA strand elongation involved in DNA replication (GO:0006271)4.40464648
20sister chromatid segregation (GO:0000819)4.38752466
21folic acid-containing compound biosynthetic process (GO:0009396)4.30622525
22histone exchange (GO:0043486)4.26123419
23DNA strand elongation (GO:0022616)4.20592035
24mitotic recombination (GO:0006312)4.15098970
25telomere maintenance via recombination (GO:0000722)4.14140613
26protein maturation by protein folding (GO:0022417)4.13399529
27regulation of spindle organization (GO:0090224)4.10124639
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.09383341
29DNA replication checkpoint (GO:0000076)4.09267575
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.01493004
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.99836212
32meiotic chromosome segregation (GO:0045132)3.88240994
33spindle checkpoint (GO:0031577)3.86334839
34mitotic nuclear envelope disassembly (GO:0007077)3.75925074
35spindle assembly checkpoint (GO:0071173)3.71826329
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.71400878
37negative regulation of mitotic sister chromatid separation (GO:2000816)3.70792906
38negative regulation of mitotic sister chromatid segregation (GO:0033048)3.70792906
39negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.70792906
40negative regulation of sister chromatid segregation (GO:0033046)3.70792906
41ATP synthesis coupled proton transport (GO:0015986)3.69992452
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.69992452
43DNA replication initiation (GO:0006270)3.69749590
44negative regulation of chromosome segregation (GO:0051985)3.69277418
45DNA replication-dependent nucleosome assembly (GO:0006335)3.68826690
46DNA replication-dependent nucleosome organization (GO:0034723)3.68826690
47regulation of chromosome segregation (GO:0051983)3.66626005
48mitotic spindle assembly checkpoint (GO:0007094)3.60890278
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.59777475
50DNA unwinding involved in DNA replication (GO:0006268)3.58469606
51histone-serine phosphorylation (GO:0035404)3.55982638
52* chromosome segregation (GO:0007059)3.55585635
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55236743
54membrane disassembly (GO:0030397)3.54865507
55nuclear envelope disassembly (GO:0051081)3.54865507
56signal peptide processing (GO:0006465)3.51892280
57mitochondrial respiratory chain complex assembly (GO:0033108)3.49563156
58telomere maintenance via telomere lengthening (GO:0010833)3.48572429
59protein localization to chromosome (GO:0034502)3.48513260
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.47291066
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.47078369
62protein complex biogenesis (GO:0070271)3.46867269
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.46366113
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46292336
65mitotic spindle checkpoint (GO:0071174)3.45371759
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44467793
67replication fork processing (GO:0031297)3.44160981
68regulation of mitotic sister chromatid separation (GO:0010965)3.43077622
69regulation of mitotic sister chromatid segregation (GO:0033047)3.43077622
70regulation of sister chromatid segregation (GO:0033045)3.43077622
71negative regulation of DNA-dependent DNA replication (GO:2000104)3.37038078
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36340672
73mitochondrial respiratory chain complex I assembly (GO:0032981)3.36340672
74NADH dehydrogenase complex assembly (GO:0010257)3.36340672
75chromatin assembly or disassembly (GO:0006333)3.33997849
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.33965802
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.33965802
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.33965802
79pteridine-containing compound biosynthetic process (GO:0042559)3.30374127
80regulation of mitotic spindle organization (GO:0060236)3.29274465
81endocrine pancreas development (GO:0031018)3.27881536
82positive regulation of chromosome segregation (GO:0051984)3.23831097
83deoxyribonucleotide biosynthetic process (GO:0009263)3.22669311
84DNA double-strand break processing (GO:0000729)3.21764428
85COPII vesicle coating (GO:0048208)3.19256765
86nuclear pore organization (GO:0006999)3.18882218
87chromosome condensation (GO:0030261)3.17674258
88nucleobase biosynthetic process (GO:0046112)3.15611515
89recombinational repair (GO:0000725)3.11940433
90water-soluble vitamin biosynthetic process (GO:0042364)3.11106227
91protein K6-linked ubiquitination (GO:0085020)3.11009496
92ATP-dependent chromatin remodeling (GO:0043044)3.10755839
93purine nucleobase biosynthetic process (GO:0009113)3.09669536
94double-strand break repair via homologous recombination (GO:0000724)3.07246453
95resolution of meiotic recombination intermediates (GO:0000712)3.06550645
96maturation of 5.8S rRNA (GO:0000460)3.06541088
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.04477697
98protein retention in ER lumen (GO:0006621)3.04076442
99regulation of mitotic spindle checkpoint (GO:1903504)3.03095466
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03095466
101* mitotic cell cycle (GO:0000278)3.02694615
102protein-cofactor linkage (GO:0018065)3.02649219
103cellular ketone body metabolic process (GO:0046950)3.01213221
104regulation of nuclear cell cycle DNA replication (GO:0033262)3.00623433
105regulation of sister chromatid cohesion (GO:0007063)2.99399864
106respiratory chain complex IV assembly (GO:0008535)2.98247650
107regulation of centrosome cycle (GO:0046605)2.97408678
108electron transport chain (GO:0022900)2.95937832
109proteasome assembly (GO:0043248)2.94484648
110reciprocal DNA recombination (GO:0035825)2.93309564
111reciprocal meiotic recombination (GO:0007131)2.93309564
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93280008
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92967719
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92849036
115respiratory electron transport chain (GO:0022904)2.92533364
116detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90003376
117sequestering of metal ion (GO:0051238)2.88889980
118synapsis (GO:0007129)2.87958857
119centriole replication (GO:0007099)2.87378087
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86362751
121maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85743056
122negative regulation of mitosis (GO:0045839)2.84771565
123IMP biosynthetic process (GO:0006188)2.84571020
124negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.81777275
125DNA packaging (GO:0006323)2.81529040
126mitotic sister chromatid cohesion (GO:0007064)2.81389083
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80463334
128microtubule depolymerization (GO:0007019)2.79837405
129postreplication repair (GO:0006301)2.79422943
130nuclear pore complex assembly (GO:0051292)2.79129199
131nucleosome assembly (GO:0006334)2.78825665
132telomere maintenance (GO:0000723)2.78245218
133telomere organization (GO:0032200)2.77301756
134ketone body metabolic process (GO:1902224)2.77269040
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76482611
136peptide hormone processing (GO:0016486)2.76386465
137DNA topological change (GO:0006265)2.74554630
138cytochrome complex assembly (GO:0017004)2.71483222
139RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68250658
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68250658
141protein neddylation (GO:0045116)2.67066566
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.66511123
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66511123
144regulation of centriole replication (GO:0046599)2.61533443
145kynurenine metabolic process (GO:0070189)2.60713662
146L-fucose metabolic process (GO:0042354)2.60375058
147L-fucose catabolic process (GO:0042355)2.60375058
148fucose catabolic process (GO:0019317)2.60375058
149nephron tubule morphogenesis (GO:0072078)2.60351323
150nephron epithelium morphogenesis (GO:0072088)2.60351323
151nonmotile primary cilium assembly (GO:0035058)2.60054951
152pseudouridine synthesis (GO:0001522)2.56519839
153regulation of DNA endoreduplication (GO:0032875)2.56321332
154intracellular protein transmembrane import (GO:0044743)2.56301305
155indole-containing compound catabolic process (GO:0042436)2.53254887
156indolalkylamine catabolic process (GO:0046218)2.53254887
157tryptophan catabolic process (GO:0006569)2.53254887
158negative regulation of telomere maintenance (GO:0032205)2.53209331
159behavioral response to ethanol (GO:0048149)2.52135797
160DNA deamination (GO:0045006)2.52036117
161platelet dense granule organization (GO:0060155)2.51471433
162ubiquinone biosynthetic process (GO:0006744)2.50757550
163indolalkylamine metabolic process (GO:0006586)2.50373954
164cornea development in camera-type eye (GO:0061303)2.49796638
165regulation of gene silencing by RNA (GO:0060966)2.47808273
166regulation of posttranscriptional gene silencing (GO:0060147)2.47808273
167regulation of gene silencing by miRNA (GO:0060964)2.47808273
168transcription elongation from RNA polymerase III promoter (GO:0006385)2.45069654
169termination of RNA polymerase III transcription (GO:0006386)2.45069654
170centrosome organization (GO:0051297)2.44553114
171rRNA catabolic process (GO:0016075)2.43178492
172DNA ligation (GO:0006266)2.42617312
173ubiquinone metabolic process (GO:0006743)2.40541729
174peptidyl-histidine modification (GO:0018202)2.39674829
175regulation of mesoderm development (GO:2000380)2.38795113
176male meiosis I (GO:0007141)2.37535745
177mitochondrial RNA metabolic process (GO:0000959)2.37212964
178RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.35036645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.45375225
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.01880355
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.11044524
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.07820483
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78571641
6ZNF274_21170338_ChIP-Seq_K562_Hela3.61142035
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.59448957
8VDR_22108803_ChIP-Seq_LS180_Human3.14728503
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08936246
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.07003931
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96549335
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.89905890
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76893536
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72689142
15AR_21909140_ChIP-Seq_LNCAP_Human2.63155906
16EZH2_22144423_ChIP-Seq_EOC_Human2.56980246
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54631005
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48061992
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46331300
20* ETS1_20019798_ChIP-Seq_JURKAT_Human2.42174499
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38776956
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35745716
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34688496
24EWS_26573619_Chip-Seq_HEK293_Human2.33731535
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28320206
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.28016278
27GBX2_23144817_ChIP-Seq_PC3_Human2.26493349
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26149777
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24700969
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23392823
31FUS_26573619_Chip-Seq_HEK293_Human2.19964103
32VDR_23849224_ChIP-Seq_CD4+_Human2.18830362
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17899732
34XRN2_22483619_ChIP-Seq_HELA_Human2.16018343
35DCP1A_22483619_ChIP-Seq_HELA_Human2.13055280
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11611347
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06785443
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05434552
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04353947
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.97554515
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95448773
42FOXP3_21729870_ChIP-Seq_TREG_Human1.94910814
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.94182793
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93339591
45GABP_19822575_ChIP-Seq_HepG2_Human1.92752818
46IGF1R_20145208_ChIP-Seq_DFB_Human1.91558969
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89533050
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87096495
49ELK1_19687146_ChIP-ChIP_HELA_Human1.86801876
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85997726
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85194656
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75443692
53TAF15_26573619_Chip-Seq_HEK293_Human1.73138623
54P300_19829295_ChIP-Seq_ESCs_Human1.73023277
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70942857
56TTF2_22483619_ChIP-Seq_HELA_Human1.68343897
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67999941
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65839935
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64623619
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.63168815
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.57404815
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56547844
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55324053
64IRF1_19129219_ChIP-ChIP_H3396_Human1.54826413
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54346136
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53972694
67* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51965237
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50578892
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50358446
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50285074
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49995848
72TFEB_21752829_ChIP-Seq_HELA_Human1.49618668
73ER_23166858_ChIP-Seq_MCF-7_Human1.48956533
74KDM5A_27292631_Chip-Seq_BREAST_Human1.48744306
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48516939
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48479128
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48312184
78CIITA_25753668_ChIP-Seq_RAJI_Human1.47921873
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46951502
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.44439117
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42903970
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41979198
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.40828925
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38546553
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34677717
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.34082612
87TP53_22573176_ChIP-Seq_HFKS_Human1.32396519
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32193960
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.32184248
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29938955
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29860993
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28117922
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26684557
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.26684557
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25862645
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23651191
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23438576
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23313716
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22432416
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.20681544
101RNF2_27304074_Chip-Seq_NSC_Mouse1.18212922
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.17734559
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14231596
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.13183540
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12655638
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12538521
107BCAT_22108803_ChIP-Seq_LS180_Human1.11014383
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10799394
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10779036
110* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10079780
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.08889686
112* STAT3_23295773_ChIP-Seq_U87_Human1.08833877
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08201094
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06696442
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.05964239
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05950598
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.05282064
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05117893
119NANOG_19829295_ChIP-Seq_ESCs_Human1.04803478
120SOX2_19829295_ChIP-Seq_ESCs_Human1.04803478
121NFE2_27457419_Chip-Seq_LIVER_Mouse1.03980529
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03692265
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03606968
124MYC_22102868_ChIP-Seq_BL_Human1.03587443
125AR_25329375_ChIP-Seq_VCAP_Human1.03517579
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03406191
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03384613
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03384613
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03163358
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03126400
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02263346
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02102894
133AR_20517297_ChIP-Seq_VCAP_Human1.01751727
134SMAD4_21799915_ChIP-Seq_A2780_Human1.01253263
135HTT_18923047_ChIP-ChIP_STHdh_Human1.00696038
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00471603
137CBP_20019798_ChIP-Seq_JUKART_Human0.99366209
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99366209
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99358799
140TCF4_22108803_ChIP-Seq_LS180_Human0.95778855
141RUNX2_22187159_ChIP-Seq_PCA_Human0.95143231
142SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94047920
143GATA3_21878914_ChIP-Seq_MCF-7_Human0.93860347
144TCF4_23295773_ChIP-Seq_U87_Human0.93735995
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92335768
146NCOR_22424771_ChIP-Seq_293T_Human0.92147891
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.92042273
148E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89412078
149SOX17_20123909_ChIP-Seq_XEN_Mouse0.87677066
150CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85912001
151POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85093242
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84823158
153RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84539234
154ELK1_22589737_ChIP-Seq_MCF10A_Human0.83571802
155MYC_18940864_ChIP-ChIP_HL60_Human0.81580442
156GATA1_22025678_ChIP-Seq_K562_Human0.81030339
157SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80489119
158* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79790869
159TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78855717
160CHD1_26751641_Chip-Seq_LNCaP_Human0.77196610
161KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74297879
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72942518
163HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71311846
164HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.71136544
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.70029139
166SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69129338
167CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.69109881
168ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.69104642
169SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.68927516
170TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68877722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51127274
2MP0003111_abnormal_nucleus_morphology4.03484254
3MP0010094_abnormal_chromosome_stability3.97315883
4MP0004957_abnormal_blastocyst_morpholog3.94557831
5MP0003283_abnormal_digestive_organ3.64988390
6MP0002877_abnormal_melanocyte_morpholog3.58692785
7MP0003077_abnormal_cell_cycle3.58443934
8MP0008057_abnormal_DNA_replication3.37535163
9MP0003136_yellow_coat_color3.07692367
10MP0008058_abnormal_DNA_repair2.84510077
11MP0008007_abnormal_cellular_replicative2.73083588
12MP0003123_paternal_imprinting2.47418029
13MP0002693_abnormal_pancreas_physiology2.46487061
14MP0001944_abnormal_pancreas_morphology2.25061604
15MP0005379_endocrine/exocrine_gland_phen2.13571264
16MP0005220_abnormal_exocrine_pancreas2.12662354
17MP0008932_abnormal_embryonic_tissue2.10141890
18MP0000678_abnormal_parathyroid_gland2.03939295
19MP0002102_abnormal_ear_morphology2.03538595
20MP0001730_embryonic_growth_arrest1.98704151
21MP0010307_abnormal_tumor_latency1.97074122
22MP0000013_abnormal_adipose_tissue1.93600795
23MP0004043_abnormal_pH_regulation1.91791369
24MP0001485_abnormal_pinna_reflex1.91662695
25MP0005551_abnormal_eye_electrophysiolog1.88731726
26MP0008877_abnormal_DNA_methylation1.81496954
27MP0000372_irregular_coat_pigmentation1.80622687
28MP0006072_abnormal_retinal_apoptosis1.78361074
29MP0001968_abnormal_touch/_nociception1.78350450
30MP0002736_abnormal_nociception_after1.75973153
31MP0003890_abnormal_embryonic-extraembry1.75926485
32MP0000350_abnormal_cell_proliferation1.73466378
33MP0002653_abnormal_ependyma_morphology1.72413212
34MP0009046_muscle_twitch1.70758204
35MP0001529_abnormal_vocalization1.69608174
36MP0003183_abnormal_peptide_metabolism1.64693309
37MP0004885_abnormal_endolymph1.63759359
38MP0004142_abnormal_muscle_tone1.61797304
39MP0006054_spinal_hemorrhage1.59808220
40MP0004147_increased_porphyrin_level1.57873019
41MP0005084_abnormal_gallbladder_morpholo1.54676337
42MP0001697_abnormal_embryo_size1.53286795
43MP0009745_abnormal_behavioral_response1.52281516
44MP0006292_abnormal_olfactory_placode1.48788021
45MP0002909_abnormal_adrenal_gland1.47720258
46MP0000427_abnormal_hair_cycle1.46215407
47MP0003121_genomic_imprinting1.45414694
48MP0000566_synostosis1.44290329
49MP0002163_abnormal_gland_morphology1.43957505
50MP0000569_abnormal_digit_pigmentation1.41714937
51MP0010386_abnormal_urinary_bladder1.41208810
52MP0004264_abnormal_extraembryonic_tissu1.40039750
53MP0005645_abnormal_hypothalamus_physiol1.36285606
54MP0005380_embryogenesis_phenotype1.35407369
55MP0001672_abnormal_embryogenesis/_devel1.35407369
56MP0008872_abnormal_physiological_respon1.35359690
57MP0005076_abnormal_cell_differentiation1.33639779
58MP0002080_prenatal_lethality1.33564786
59MP0002272_abnormal_nervous_system1.32269899
60MP0003119_abnormal_digestive_system1.30598167
61MP0010352_gastrointestinal_tract_polyps1.30171680
62MP0003786_premature_aging1.30021121
63MP0002085_abnormal_embryonic_tissue1.25867932
64MP0003937_abnormal_limbs/digits/tail_de1.24362179
65MP0003011_delayed_dark_adaptation1.23305396
66MP0003646_muscle_fatigue1.22151634
67MP0002277_abnormal_respiratory_mucosa1.21253971
68MP0001986_abnormal_taste_sensitivity1.20888577
69MP0000313_abnormal_cell_death1.20235664
70MP0005646_abnormal_pituitary_gland1.19018246
71MP0004742_abnormal_vestibular_system1.18910810
72MP0003984_embryonic_growth_retardation1.17386193
73MP0009672_abnormal_birth_weight1.17284604
74MP0008875_abnormal_xenobiotic_pharmacok1.16809585
75MP0002084_abnormal_developmental_patter1.15861303
76MP0009379_abnormal_foot_pigmentation1.15358518
77MP0002088_abnormal_embryonic_growth/wei1.13672774
78MP0005174_abnormal_tail_pigmentation1.08252123
79MP0002928_abnormal_bile_duct1.08155049
80MP0000647_abnormal_sebaceous_gland1.08085673
81MP0002234_abnormal_pharynx_morphology1.07716886
82MP0002837_dystrophic_cardiac_calcinosis1.06525746
83MP0009697_abnormal_copulation1.06370873
84MP0002210_abnormal_sex_determination1.04958243
85MP0003880_abnormal_central_pattern1.04746525
86MP0003195_calcinosis1.04044456
87MP0002095_abnormal_skin_pigmentation1.04040699
88MP0003122_maternal_imprinting1.03894201
89MP0005389_reproductive_system_phenotype1.03614133
90MP0002078_abnormal_glucose_homeostasis1.02509860
91MP0000613_abnormal_salivary_gland1.01787453
92MP0002086_abnormal_extraembryonic_tissu1.00726863
93MP0002735_abnormal_chemical_nociception1.00601795
94MP0005195_abnormal_posterior_eye1.00445984
95MP0006276_abnormal_autonomic_nervous0.99861698
96MP0001145_abnormal_male_reproductive0.99858713
97MP0002019_abnormal_tumor_incidence0.99431970
98MP0002876_abnormal_thyroid_physiology0.99023337
99MP0000490_abnormal_crypts_of0.98628403
100MP0004197_abnormal_fetal_growth/weight/0.98167211
101MP0002064_seizures0.97592155
102MP0002572_abnormal_emotion/affect_behav0.97143487
103MP0002557_abnormal_social/conspecific_i0.96766931
104MP0002938_white_spotting0.96739721
105MP0001929_abnormal_gametogenesis0.96246636
106MP0004145_abnormal_muscle_electrophysio0.96164513
107MP0008789_abnormal_olfactory_epithelium0.95473501
108MP0002638_abnormal_pupillary_reflex0.94989890
109MP0001286_abnormal_eye_development0.94618978
110MP0000003_abnormal_adipose_tissue0.93759477
111MP0000026_abnormal_inner_ear0.93478973
112MP0000462_abnormal_digestive_system0.93291598
113MP0001486_abnormal_startle_reflex0.93063735
114MP0000049_abnormal_middle_ear0.92796538
115MP0009703_decreased_birth_body0.91968298
116MP0001919_abnormal_reproductive_system0.91229137
117MP0004215_abnormal_myocardial_fiber0.90716989
118MP0003718_maternal_effect0.90519401
119MP0003698_abnormal_male_reproductive0.90195117
120MP0003806_abnormal_nucleotide_metabolis0.89387655
121MP0001324_abnormal_eye_pigmentation0.88373499
122MP0002751_abnormal_autonomic_nervous0.87534409
123MP0009780_abnormal_chondrocyte_physiolo0.87533374
124MP0002733_abnormal_thermal_nociception0.87496671
125MP0000653_abnormal_sex_gland0.87090997
126MP0002067_abnormal_sensory_capabilities0.86036578
127MP0005408_hypopigmentation0.84966005
128MP0003137_abnormal_impulse_conducting0.84712967
129MP0005391_vision/eye_phenotype0.84090398
130MP0004133_heterotaxia0.83341319
131MP0000778_abnormal_nervous_system0.82425859
132MP0005377_hearing/vestibular/ear_phenot0.82410779
133MP0003878_abnormal_ear_physiology0.82410779
134MP0001970_abnormal_pain_threshold0.81083758
135MP0002160_abnormal_reproductive_system0.80007762
136MP0006036_abnormal_mitochondrial_physio0.78802039
137MP0010030_abnormal_orbit_morphology0.74953576
138MP0001293_anophthalmia0.72683448
139MP0000358_abnormal_cell_content/0.72000176
140MP0005384_cellular_phenotype0.70347234
141MP0001186_pigmentation_phenotype0.70119070
142MP0005257_abnormal_intraocular_pressure0.68540036
143MP0000631_abnormal_neuroendocrine_gland0.68498619
144MP0009643_abnormal_urine_homeostasis0.67603135
145MP0005621_abnormal_cell_physiology0.65918834
146MP0001119_abnormal_female_reproductive0.65484265
147MP0003567_abnormal_fetal_cardiomyocyte0.65149770
148MP0000428_abnormal_craniofacial_morphol0.64777806
149MP0004808_abnormal_hematopoietic_stem0.64410313
150MP0003943_abnormal_hepatobiliary_system0.63483311
151MP0002396_abnormal_hematopoietic_system0.62582749
152MP0005636_abnormal_mineral_homeostasis0.59410304
153MP0009333_abnormal_splenocyte_physiolog0.59247549
154MP0005253_abnormal_eye_physiology0.58897307
155MP0001756_abnormal_urination0.58473701
156MP0000703_abnormal_thymus_morphology0.58370336
157MP0003787_abnormal_imprinting0.58316084
158MP0002970_abnormal_white_adipose0.57576408
159MP0003186_abnormal_redox_activity0.56842604

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.96993335
2Hypoglycemic seizures (HP:0002173)4.61218535
3Hypoglycemic coma (HP:0001325)4.49988989
4Symptomatic seizures (HP:0011145)3.99235459
5Birth length less than 3rd percentile (HP:0003561)3.95480566
6Pancreatic islet-cell hyperplasia (HP:0004510)3.81524576
7Abnormality of the pancreatic islet cells (HP:0006476)3.73505266
8Abnormality of endocrine pancreas physiology (HP:0012093)3.73505266
9Molar tooth sign on MRI (HP:0002419)3.72122597
10Abnormality of midbrain morphology (HP:0002418)3.72122597
11True hermaphroditism (HP:0010459)3.70944923
1211 pairs of ribs (HP:0000878)3.64690001
13Abnormal pancreas size (HP:0012094)3.24640102
14Degeneration of anterior horn cells (HP:0002398)3.24392936
15Abnormality of the anterior horn cell (HP:0006802)3.24392936
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.22768922
17Nephronophthisis (HP:0000090)3.18802862
18Insulin-resistant diabetes mellitus (HP:0000831)3.07777081
19Hyperglycemia (HP:0003074)3.04711869
20Missing ribs (HP:0000921)2.97033894
21Abnormality of chromosome stability (HP:0003220)2.96296736
22Type II lissencephaly (HP:0007260)2.92135594
23Acute necrotizing encephalopathy (HP:0006965)2.91797039
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.89445597
25Congenital, generalized hypertrichosis (HP:0004540)2.88908925
26Abnormality of alanine metabolism (HP:0010916)2.88530094
27Hyperalaninemia (HP:0003348)2.88530094
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88530094
29Carpal bone hypoplasia (HP:0001498)2.88046724
30Chromsome breakage (HP:0040012)2.86760810
31Aplastic anemia (HP:0001915)2.86085925
32Volvulus (HP:0002580)2.77939424
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73819930
34Meckel diverticulum (HP:0002245)2.73768485
35Generalized aminoaciduria (HP:0002909)2.73684651
36Type I transferrin isoform profile (HP:0003642)2.71609472
37Breast hypoplasia (HP:0003187)2.70798861
38Acute encephalopathy (HP:0006846)2.68517447
39Sclerocornea (HP:0000647)2.68088534
40Patellar aplasia (HP:0006443)2.65437368
41Congenital stationary night blindness (HP:0007642)2.62153186
42Abnormality of the renal medulla (HP:0100957)2.61039106
43Medial flaring of the eyebrow (HP:0010747)2.59593165
44Abnormality of the ileum (HP:0001549)2.57588071
45Abnormality of the labia minora (HP:0012880)2.56578556
46Mitochondrial inheritance (HP:0001427)2.52145694
47Abnormality of the preputium (HP:0100587)2.50103187
48Colon cancer (HP:0003003)2.49748940
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47861059
50Prominent metopic ridge (HP:0005487)2.47421972
51Progressive macrocephaly (HP:0004481)2.46809727
52Abnormal mitochondria in muscle tissue (HP:0008316)2.45400131
53Increased CSF lactate (HP:0002490)2.44290086
54Reticulocytopenia (HP:0001896)2.43328518
55Abnormal biliary tract morphology (HP:0012440)2.43057829
56Aplasia/Hypoplasia of the patella (HP:0006498)2.42593268
57Duodenal stenosis (HP:0100867)2.41812078
58Small intestinal stenosis (HP:0012848)2.41812078
59Large for gestational age (HP:0001520)2.41379251
60Limb hypertonia (HP:0002509)2.39367996
61Pendular nystagmus (HP:0012043)2.38512342
62Cystic liver disease (HP:0006706)2.37071470
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36910554
64Abnormal protein N-linked glycosylation (HP:0012347)2.36910554
65Abnormal protein glycosylation (HP:0012346)2.36910554
66Abnormal glycosylation (HP:0012345)2.36910554
67Myelodysplasia (HP:0002863)2.32875725
68Abnormality of the renal cortex (HP:0011035)2.32164078
69Male pseudohermaphroditism (HP:0000037)2.31161598
70Oral leukoplakia (HP:0002745)2.29854487
71Abnormality of the duodenum (HP:0002246)2.29448658
72Late onset (HP:0003584)2.26271581
733-Methylglutaconic aciduria (HP:0003535)2.24956607
74Bone marrow hypocellularity (HP:0005528)2.24201257
75Insulin resistance (HP:0000855)2.22756581
76Furrowed tongue (HP:0000221)2.21525414
77Tubular atrophy (HP:0000092)2.21521345
78Flat capital femoral epiphysis (HP:0003370)2.21099491
79Cerebellar dysplasia (HP:0007033)2.20992092
80Increased nuchal translucency (HP:0010880)2.20605625
81Impulsivity (HP:0100710)2.20125575
82Abnormality of the pons (HP:0007361)2.19518604
83Concave nail (HP:0001598)2.18866235
84Rough bone trabeculation (HP:0100670)2.18774358
85Hypoplasia of the pons (HP:0012110)2.18315767
86Intestinal atresia (HP:0011100)2.17692716
87Microretrognathia (HP:0000308)2.17508341
88Abolished electroretinogram (ERG) (HP:0000550)2.17230150
89Attenuation of retinal blood vessels (HP:0007843)2.16999665
90Neoplasm of the pancreas (HP:0002894)2.15408376
91Triphalangeal thumb (HP:0001199)2.14787661
92Retinal dysplasia (HP:0007973)2.14612146
93Nephroblastoma (Wilms tumor) (HP:0002667)2.14595917
94Inability to walk (HP:0002540)2.13462356
95Increased hepatocellular lipid droplets (HP:0006565)2.13068410
96Ependymoma (HP:0002888)2.12998786
97Septo-optic dysplasia (HP:0100842)2.12046370
98Aplasia/Hypoplasia of the tongue (HP:0010295)2.11614167
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11431535
100Abnormality of the metopic suture (HP:0005556)2.11118091
101Anencephaly (HP:0002323)2.08242965
102Spinal muscular atrophy (HP:0007269)2.07867131
103Abnormal lung lobation (HP:0002101)2.07772197
104Lipid accumulation in hepatocytes (HP:0006561)2.05398144
105Clubbing of toes (HP:0100760)2.05303913
106Osteomalacia (HP:0002749)2.05077890
107Optic nerve hypoplasia (HP:0000609)2.04721329
108Pancreatic cysts (HP:0001737)2.04442329
109Sloping forehead (HP:0000340)2.03801089
110Abnormality of calcium-phosphate metabolism (HP:0100530)2.03668300
111Chronic hepatic failure (HP:0100626)2.03191139
112Premature graying of hair (HP:0002216)2.02961933
113Absent radius (HP:0003974)2.02322617
114Gait imbalance (HP:0002141)2.01980083
115Optic disc pallor (HP:0000543)2.01690944
116Lissencephaly (HP:0001339)2.01430034
117Cafe-au-lait spot (HP:0000957)1.99081743
118Congenital primary aphakia (HP:0007707)1.98881040
119Progressive inability to walk (HP:0002505)1.97782298
120Methylmalonic acidemia (HP:0002912)1.96621850
121Ovarian neoplasm (HP:0100615)1.95414347
122Absent thumb (HP:0009777)1.95250089
123Ketoacidosis (HP:0001993)1.93977065
124Embryonal renal neoplasm (HP:0011794)1.93973193
125Pancreatic fibrosis (HP:0100732)1.93443643
126Neoplasm of the colon (HP:0100273)1.92498914
127Duplicated collecting system (HP:0000081)1.90667296
128Aplasia/hypoplasia of the uterus (HP:0008684)1.88972224
129Congenital hepatic fibrosis (HP:0002612)1.88549503
130Abnormality of the renal collecting system (HP:0004742)1.87933828
131Gastrointestinal atresia (HP:0002589)1.87707584
132Hepatocellular necrosis (HP:0001404)1.87546514
133Secondary amenorrhea (HP:0000869)1.87402950
134Exocrine pancreatic insufficiency (HP:0001738)1.86822124
135Intestinal polyposis (HP:0200008)1.86195847
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.86043227
137Abnormality of the carotid arteries (HP:0005344)1.85704118
138Horseshoe kidney (HP:0000085)1.85100251
139Poor head control (HP:0002421)1.84065038
140Small hand (HP:0200055)1.83814395
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.83738636
142Hypoplasia of the fovea (HP:0007750)1.83738636
143Nephrogenic diabetes insipidus (HP:0009806)1.83437473
144Irregular vertebral endplates (HP:0003301)1.83174109
145Medulloblastoma (HP:0002885)1.82376751
146Abnormal number of erythroid precursors (HP:0012131)1.82088622
147Absent forearm bone (HP:0003953)1.81999062
148Aplasia involving forearm bones (HP:0009822)1.81999062
149Dandy-Walker malformation (HP:0001305)1.81378821
150Hepatic necrosis (HP:0002605)1.79418982
151Genital tract atresia (HP:0001827)1.79236910
152Postaxial foot polydactyly (HP:0001830)1.79052111
153Thoracolumbar scoliosis (HP:0002944)1.77236413
154Preaxial hand polydactyly (HP:0001177)1.76643128
155Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76428595
156Keratoconus (HP:0000563)1.76410855
157Increased corneal curvature (HP:0100692)1.76410855
158Optic nerve coloboma (HP:0000588)1.76191456
159Abnormality of cells of the erythroid lineage (HP:0012130)1.75556651
160Facial hemangioma (HP:0000329)1.75157482
161Increased serum lactate (HP:0002151)1.74847151
162Oligodactyly (hands) (HP:0001180)1.74699633
163Hyperglycinuria (HP:0003108)1.73906232
164Intestinal polyp (HP:0005266)1.73695005
165Vaginal atresia (HP:0000148)1.73430755
166Ectopic kidney (HP:0000086)1.72661712
167Oligohydramnios (HP:0001562)1.72452144
168Abnormality of the fovea (HP:0000493)1.72214685
169Bilateral microphthalmos (HP:0007633)1.72214282
170Biliary tract neoplasm (HP:0100574)1.71889538
171Slender long bone (HP:0003100)1.71879545
172Facial cleft (HP:0002006)1.67576677
173Short middle phalanx of the 5th finger (HP:0004220)1.66856596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.81164927
2PASK4.57474731
3WEE13.83440867
4CDC73.76430143
5BRSK23.68280605
6NEK23.02124706
7CCNB12.83788238
8BMPR1B2.78636801
9BRSK12.77740293
10PNCK2.67767353
11NEK12.61551950
12ACVR1B2.60581089
13INSRR2.48488192
14TTK2.38156627
15PLK12.15608068
16ADRBK22.15480183
17VRK11.96451335
18VRK21.95049185
19NUAK11.94004861
20EIF2AK31.91780393
21AURKB1.90299419
22SRPK11.87839178
23PLK41.86316327
24EIF2AK11.82373984
25GRK11.81717443
26TNIK1.72606897
27SCYL21.67103625
28MAP4K21.65984846
29STK161.63417804
30DYRK31.59595471
31FLT31.54475641
32MAPK131.51721265
33PLK31.50003148
34PRKD31.47464337
35AURKA1.39478083
36TAF11.34172303
37CHEK21.33678603
38ATR1.33474818
39PINK11.31659557
40BRAF1.31250545
41CASK1.31217876
42RPS6KA41.30456739
43TLK11.28273201
44HIPK21.21938725
45STK41.21489172
46PBK1.20182347
47FRK1.18679522
48CDK71.18428521
49TRIM281.18176841
50TESK21.17900711
51MAP3K41.16312074
52MELK1.11306416
53OXSR11.10035912
54MST41.08745821
55MAP3K81.08047976
56CHEK11.02075573
57MAPK151.01409780
58TESK11.01078012
59UHMK11.00944680
60PRKCG0.96857633
61STK390.95616922
62CDK120.95300663
63ZAK0.94196382
64TAOK30.91365847
65NME10.90513271
66BCKDK0.89835269
67WNK30.89062582
68ATM0.86580173
69CDK40.77380275
70BRD40.77049913
71CDK80.76143337
72STK100.75717091
73NME20.74314412
74DAPK20.74047139
75ADRBK10.72615665
76IRAK10.72476860
77NTRK30.72394818
78MKNK10.70429209
79CDK20.68934967
80PLK20.68821540
81DYRK1B0.67070584
82MARK30.66622546
83TSSK60.65704752
84EIF2AK20.65644462
85CDK10.64934017
86CSNK1G20.63621470
87PAK30.63081688
88CDK60.60097512
89CDC42BPA0.56718382
90CSNK1G10.55787002
91MAP2K70.55442410
92PRKCE0.53644274
93CSNK2A10.53041343
94CDK30.52761543
95FGFR20.52114029
96RPS6KB20.51935123
97MAPKAPK50.50582742
98CSNK1G30.50152585
99PTK2B0.49326243
100STK38L0.48894804
101MAP3K20.48796768
102CSNK2A20.47855036
103RPS6KA50.45897600
104MKNK20.45429294
105PRKCI0.44872845
106EPHA20.42733024
107WNK40.42187231
108TIE10.42037413
109PRKDC0.41849789
110BCR0.41225466
111PAK40.41136512
112CAMKK20.38487993
113MUSK0.36762056
114CDK190.36718090
115PKN10.36070630
116ERN10.33115053
117TGFBR10.32792146
118PIK3CG0.32549811
119MAP3K30.32234102
120STK30.31973152
121CAMK2A0.31814448
122TXK0.31143552
123MAP3K100.31105901
124CSNK1A10.31021104
125PRKACA0.30590858
126CSNK1E0.30443357
127MAPK140.30171599
128MARK10.29549745
129PIM10.29545173
130PAK10.28766490
131CSNK1A1L0.28187985
132AKT30.23201574
133TEC0.22943723
134AKT10.22825723
135MAPK110.21632878
136CHUK0.21314988
137ERBB30.20498456
138LIMK10.19968647
139IRAK30.19919583
140DYRK20.18887626
141PTK20.18013112
142PDGFRA0.17748020
143KDR0.15110803
144MTOR0.13545513
145MAPKAPK20.12737743
146GSK3B0.12467703

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.21968523
2DNA replication_Homo sapiens_hsa030304.49355944
3Mismatch repair_Homo sapiens_hsa034304.14784453
4Protein export_Homo sapiens_hsa030604.13563936
5Homologous recombination_Homo sapiens_hsa034403.13807853
6Cell cycle_Homo sapiens_hsa041103.01919980
7Base excision repair_Homo sapiens_hsa034102.80204587
8Spliceosome_Homo sapiens_hsa030402.62801586
9RNA transport_Homo sapiens_hsa030132.51696725
10Nucleotide excision repair_Homo sapiens_hsa034202.49959800
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38594407
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34287633
13One carbon pool by folate_Homo sapiens_hsa006702.33396891
14RNA polymerase_Homo sapiens_hsa030202.27630734
15Fanconi anemia pathway_Homo sapiens_hsa034602.26460979
16Proteasome_Homo sapiens_hsa030502.25502054
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.20811970
18Pyrimidine metabolism_Homo sapiens_hsa002402.09563556
19Butanoate metabolism_Homo sapiens_hsa006501.98866033
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96821163
21Non-homologous end-joining_Homo sapiens_hsa034501.88737499
22Selenocompound metabolism_Homo sapiens_hsa004501.84044045
23Phototransduction_Homo sapiens_hsa047441.82034377
24Alzheimers disease_Homo sapiens_hsa050101.74431579
25Ribosome_Homo sapiens_hsa030101.73596776
26Basal transcription factors_Homo sapiens_hsa030221.68251947
27RNA degradation_Homo sapiens_hsa030181.66016136
28p53 signaling pathway_Homo sapiens_hsa041151.65518946
29Folate biosynthesis_Homo sapiens_hsa007901.64932571
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59420269
31Nitrogen metabolism_Homo sapiens_hsa009101.56544059
32Nicotine addiction_Homo sapiens_hsa050331.53622026
33Cardiac muscle contraction_Homo sapiens_hsa042601.47163074
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40716494
35Systemic lupus erythematosus_Homo sapiens_hsa053221.36239474
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34475898
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31603352
38mRNA surveillance pathway_Homo sapiens_hsa030151.31530623
39N-Glycan biosynthesis_Homo sapiens_hsa005101.31295205
40Sulfur metabolism_Homo sapiens_hsa009201.30309716
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28556555
42Propanoate metabolism_Homo sapiens_hsa006401.24047157
43Oocyte meiosis_Homo sapiens_hsa041141.21157058
44Purine metabolism_Homo sapiens_hsa002301.13782912
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11429091
46Ether lipid metabolism_Homo sapiens_hsa005651.09372771
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08555182
48Sulfur relay system_Homo sapiens_hsa041221.04730042
49Steroid biosynthesis_Homo sapiens_hsa001000.99819985
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98041010
51Taste transduction_Homo sapiens_hsa047420.97639500
52Caffeine metabolism_Homo sapiens_hsa002320.97530199
53Alcoholism_Homo sapiens_hsa050340.97508760
54Type I diabetes mellitus_Homo sapiens_hsa049400.97476455
55Olfactory transduction_Homo sapiens_hsa047400.97299759
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94320088
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94176276
58Viral carcinogenesis_Homo sapiens_hsa052030.91354214
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89419119
60Peroxisome_Homo sapiens_hsa041460.87804852
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85116733
62Epstein-Barr virus infection_Homo sapiens_hsa051690.84290350
63Antigen processing and presentation_Homo sapiens_hsa046120.83225158
64Chemical carcinogenesis_Homo sapiens_hsa052040.80604875
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75431177
66Other glycan degradation_Homo sapiens_hsa005110.73970034
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73968896
68Insulin secretion_Homo sapiens_hsa049110.73263942
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71145342
70Vibrio cholerae infection_Homo sapiens_hsa051100.69969845
71Retinol metabolism_Homo sapiens_hsa008300.69589124
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.68303927
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68180736
74Pyruvate metabolism_Homo sapiens_hsa006200.65159684
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.65085824
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.64904297
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64534762
78Galactose metabolism_Homo sapiens_hsa000520.64118613
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62371737
80Basal cell carcinoma_Homo sapiens_hsa052170.61883660
81beta-Alanine metabolism_Homo sapiens_hsa004100.61801660
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61622905
83Morphine addiction_Homo sapiens_hsa050320.60723185
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.60523464
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60444555
86HTLV-I infection_Homo sapiens_hsa051660.57318139
87ABC transporters_Homo sapiens_hsa020100.57202491
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56696160
89Thyroid cancer_Homo sapiens_hsa052160.56085833
90Arachidonic acid metabolism_Homo sapiens_hsa005900.55680516
91Herpes simplex infection_Homo sapiens_hsa051680.54864843
92Serotonergic synapse_Homo sapiens_hsa047260.54464845
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54153869
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52587585
95Legionellosis_Homo sapiens_hsa051340.51125758
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50977780
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50785766
98GABAergic synapse_Homo sapiens_hsa047270.50077133
99Fat digestion and absorption_Homo sapiens_hsa049750.47740201
100Regulation of autophagy_Homo sapiens_hsa041400.47492453
101Lysosome_Homo sapiens_hsa041420.47029214
102Hedgehog signaling pathway_Homo sapiens_hsa043400.44675214
103Circadian entrainment_Homo sapiens_hsa047130.44641341
104Glutamatergic synapse_Homo sapiens_hsa047240.43947458
105Vitamin digestion and absorption_Homo sapiens_hsa049770.43019423
106Bladder cancer_Homo sapiens_hsa052190.42142264
107Huntingtons disease_Homo sapiens_hsa050160.40161903
108Type II diabetes mellitus_Homo sapiens_hsa049300.39463890
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39358729
110Pentose phosphate pathway_Homo sapiens_hsa000300.36855349
111Fatty acid elongation_Homo sapiens_hsa000620.35372945
112Collecting duct acid secretion_Homo sapiens_hsa049660.35272073
113Histidine metabolism_Homo sapiens_hsa003400.34792612
114MicroRNAs in cancer_Homo sapiens_hsa052060.34375568
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34109069
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33036863
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32536077
118Glycerolipid metabolism_Homo sapiens_hsa005610.29540076
119Circadian rhythm_Homo sapiens_hsa047100.28925993
120Lysine degradation_Homo sapiens_hsa003100.26958768
121Glucagon signaling pathway_Homo sapiens_hsa049220.23544717
122Prostate cancer_Homo sapiens_hsa052150.23486028
123Renin-angiotensin system_Homo sapiens_hsa046140.22818819
124FoxO signaling pathway_Homo sapiens_hsa040680.22324786
125Hepatitis B_Homo sapiens_hsa051610.22249984
126Small cell lung cancer_Homo sapiens_hsa052220.22112958
127Fructose and mannose metabolism_Homo sapiens_hsa000510.21697664
128Metabolic pathways_Homo sapiens_hsa011000.20928235
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20910398
130Linoleic acid metabolism_Homo sapiens_hsa005910.18869405
131Biosynthesis of amino acids_Homo sapiens_hsa012300.17559873
132Insulin resistance_Homo sapiens_hsa049310.17176346
133Glutathione metabolism_Homo sapiens_hsa004800.16366694
134Parkinsons disease_Homo sapiens_hsa050120.16234108
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.16011183
136Thyroid hormone synthesis_Homo sapiens_hsa049180.15779504
137mTOR signaling pathway_Homo sapiens_hsa041500.15204601
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14915842
139Vitamin B6 metabolism_Homo sapiens_hsa007500.13997196
140Prolactin signaling pathway_Homo sapiens_hsa049170.12627811
141Apoptosis_Homo sapiens_hsa042100.10579194
142Colorectal cancer_Homo sapiens_hsa052100.09913984
143Sphingolipid metabolism_Homo sapiens_hsa006000.08864266
144Oxidative phosphorylation_Homo sapiens_hsa001900.08546517
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07227793
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07147188
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07006435
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06452295
149TGF-beta signaling pathway_Homo sapiens_hsa043500.06232909
150Tryptophan metabolism_Homo sapiens_hsa003800.05131576
151Chronic myeloid leukemia_Homo sapiens_hsa052200.04695931
152AMPK signaling pathway_Homo sapiens_hsa041520.04413230
153Cocaine addiction_Homo sapiens_hsa050300.04254658

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