SPATS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.74085882
2behavioral response to nicotine (GO:0035095)4.39874597
3nuclear pore organization (GO:0006999)4.02345973
4nuclear pore complex assembly (GO:0051292)3.92867972
5piRNA metabolic process (GO:0034587)3.87673077
6mitotic metaphase plate congression (GO:0007080)3.65077216
7protein localization to kinetochore (GO:0034501)3.58562028
8regulation of gene silencing by RNA (GO:0060966)3.52891097
9regulation of posttranscriptional gene silencing (GO:0060147)3.52891097
10regulation of gene silencing by miRNA (GO:0060964)3.52891097
11mitotic sister chromatid segregation (GO:0000070)3.52763375
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51583196
13pre-miRNA processing (GO:0031054)3.41319738
14sister chromatid segregation (GO:0000819)3.37326148
15mitotic chromosome condensation (GO:0007076)3.30889126
16DNA replication-dependent nucleosome organization (GO:0034723)3.21710106
17DNA replication-dependent nucleosome assembly (GO:0006335)3.21710106
18protein localization to chromosome, centromeric region (GO:0071459)3.21701915
19regulation of sister chromatid cohesion (GO:0007063)3.18757641
20peptidyl-arginine omega-N-methylation (GO:0035247)3.13432679
21metaphase plate congression (GO:0051310)3.08453312
22regulation of centriole replication (GO:0046599)3.07661489
23positive regulation of mitotic sister chromatid separation (GO:1901970)3.03347755
24positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03347755
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03347755
26peptidyl-arginine methylation (GO:0018216)3.02851629
27peptidyl-arginine N-methylation (GO:0035246)3.02851629
28notochord development (GO:0030903)3.02149594
29histone arginine methylation (GO:0034969)3.01588942
30replication fork processing (GO:0031297)3.01524527
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.01363233
32mitotic nuclear envelope disassembly (GO:0007077)2.99946089
33heterochromatin organization (GO:0070828)2.96977949
34regulation of chromosome segregation (GO:0051983)2.96106168
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95918987
36regulation of hippo signaling (GO:0035330)2.95690810
37kinetochore organization (GO:0051383)2.93304817
38positive regulation of chromosome segregation (GO:0051984)2.93217194
39nonmotile primary cilium assembly (GO:0035058)2.92958212
40microtubule depolymerization (GO:0007019)2.92822912
41gene silencing by RNA (GO:0031047)2.88413620
42membrane disassembly (GO:0030397)2.87337475
43nuclear envelope disassembly (GO:0051081)2.87337475
44negative regulation of chromosome segregation (GO:0051985)2.84757113
45attachment of spindle microtubules to kinetochore (GO:0008608)2.84415585
46DNA methylation involved in gamete generation (GO:0043046)2.84300581
47establishment or maintenance of monopolar cell polarity (GO:0061339)2.84204524
48establishment of monopolar cell polarity (GO:0061162)2.84204524
49pore complex assembly (GO:0046931)2.84106759
50establishment of apical/basal cell polarity (GO:0035089)2.83170152
51spindle checkpoint (GO:0031577)2.82349259
52negative regulation of DNA repair (GO:0045738)2.81957905
53negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80625090
54mitotic spindle checkpoint (GO:0071174)2.80059290
55protein complex biogenesis (GO:0070271)2.78452461
56negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77773178
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77773178
58negative regulation of sister chromatid segregation (GO:0033046)2.77773178
59negative regulation of mitotic sister chromatid separation (GO:2000816)2.77773178
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76570826
61regulation of centrosome cycle (GO:0046605)2.75779237
62embryonic foregut morphogenesis (GO:0048617)2.75741900
63synaptonemal complex assembly (GO:0007130)2.74942830
64protein localization to chromosome (GO:0034502)2.74580729
65positive regulation of gastrulation (GO:2000543)2.74413128
66head development (GO:0060322)2.74371353
67regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74287864
68regulation of sister chromatid segregation (GO:0033045)2.73464210
69regulation of mitotic sister chromatid separation (GO:0010965)2.73464210
70regulation of mitotic sister chromatid segregation (GO:0033047)2.73464210
71mitotic spindle assembly checkpoint (GO:0007094)2.73102271
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72385805
73mitochondrial respiratory chain complex I assembly (GO:0032981)2.72385805
74NADH dehydrogenase complex assembly (GO:0010257)2.72385805
75kynurenine metabolic process (GO:0070189)2.71738829
76establishment of chromosome localization (GO:0051303)2.71033374
77meiotic chromosome segregation (GO:0045132)2.70294712
78spindle assembly checkpoint (GO:0071173)2.68779117
79kinetochore assembly (GO:0051382)2.67459761
80indolalkylamine catabolic process (GO:0046218)2.67332649
81tryptophan catabolic process (GO:0006569)2.67332649
82indole-containing compound catabolic process (GO:0042436)2.67332649
83behavioral response to ethanol (GO:0048149)2.66923805
84water-soluble vitamin biosynthetic process (GO:0042364)2.66077204
85histone exchange (GO:0043486)2.65537347
86male meiosis (GO:0007140)2.64274671
87polarized epithelial cell differentiation (GO:0030859)2.62642401
88kidney morphogenesis (GO:0060993)2.62206533
89mitochondrial respiratory chain complex assembly (GO:0033108)2.61786220
90chromatin remodeling at centromere (GO:0031055)2.60909425
91regulation of spindle organization (GO:0090224)2.58727475
92DNA unwinding involved in DNA replication (GO:0006268)2.58580764
93regulation of transforming growth factor beta2 production (GO:0032909)2.55748899
94regulation of meiosis I (GO:0060631)2.55146663
95synaptonemal complex organization (GO:0070193)2.53507451
96hippo signaling (GO:0035329)2.53204475
97chromosome condensation (GO:0030261)2.52229906
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52067624
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52067624
100cellular ketone body metabolic process (GO:0046950)2.51409655
101neural tube formation (GO:0001841)2.50220910
102indolalkylamine metabolic process (GO:0006586)2.50168100
103chromosome segregation (GO:0007059)2.49948660
104recombinational repair (GO:0000725)2.49400503
105mitotic sister chromatid cohesion (GO:0007064)2.49177685
106regulation of histone H3-K9 methylation (GO:0051570)2.48126609
107CENP-A containing nucleosome assembly (GO:0034080)2.46837126
108fucose catabolic process (GO:0019317)2.46689171
109L-fucose metabolic process (GO:0042354)2.46689171
110L-fucose catabolic process (GO:0042355)2.46689171
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46149608
112cornea development in camera-type eye (GO:0061303)2.45932195
113double-strand break repair via homologous recombination (GO:0000724)2.45770027
114somite development (GO:0061053)2.45457362
115resolution of meiotic recombination intermediates (GO:0000712)2.44975327
116reciprocal meiotic recombination (GO:0007131)2.43211677
117reciprocal DNA recombination (GO:0035825)2.43211677
118DNA replication-independent nucleosome organization (GO:0034724)2.43167577
119DNA replication-independent nucleosome assembly (GO:0006336)2.43167577
120transmission of nerve impulse (GO:0019226)2.43122850
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42544055
122regulation of DNA endoreduplication (GO:0032875)2.42288065
123regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.41758589
124lung-associated mesenchyme development (GO:0060484)2.41243016
125ATP-dependent chromatin remodeling (GO:0043044)2.40045065
126negative regulation of histone methylation (GO:0031061)2.39783046
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39644915
128regulation of nuclear cell cycle DNA replication (GO:0033262)2.39150268
129pyrimidine nucleobase catabolic process (GO:0006208)2.37937796
130outer ear morphogenesis (GO:0042473)2.37389052
131protein-cofactor linkage (GO:0018065)2.37172832
132sex differentiation (GO:0007548)2.36843226
133histone H2A monoubiquitination (GO:0035518)2.36634059
134protein K6-linked ubiquitination (GO:0085020)2.36558798
135somatic hypermutation of immunoglobulin genes (GO:0016446)2.36384815
136somatic diversification of immune receptors via somatic mutation (GO:0002566)2.36384815
137mesenchyme development (GO:0060485)2.36048390
138pseudouridine synthesis (GO:0001522)2.35569490
139mitotic cytokinesis (GO:0000281)2.35340482
140regulation of double-strand break repair (GO:2000779)2.35138334
141DNA replication checkpoint (GO:0000076)2.34686697
142mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.34468870
143limb bud formation (GO:0060174)2.33556954
144regulation of mitotic spindle organization (GO:0060236)2.33216837
145DNA alkylation (GO:0006305)2.32722441
146DNA methylation (GO:0006306)2.32722441
147nephron tubule morphogenesis (GO:0072078)2.32330182
148nephron epithelium morphogenesis (GO:0072088)2.32330182
149retinal ganglion cell axon guidance (GO:0031290)2.31233166
150DNA packaging (GO:0006323)2.30507948
151positive regulation of SMAD protein import into nucleus (GO:0060391)2.29898251
152negative regulation of DNA-dependent DNA replication (GO:2000104)2.29830217
153somite rostral/caudal axis specification (GO:0032525)2.29055593
154mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.25230067
155protein polyglutamylation (GO:0018095)2.24594145
156epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.24518349
157mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.23951694
158negative regulation of telomere maintenance (GO:0032205)2.22855867
159platelet dense granule organization (GO:0060155)2.22769144
160respiratory chain complex IV assembly (GO:0008535)2.22572621
161ketone body metabolic process (GO:1902224)2.20788664
162tryptophan metabolic process (GO:0006568)2.20626191
163protein localization to synapse (GO:0035418)2.20357151
164amine catabolic process (GO:0009310)2.19604047
165cellular biogenic amine catabolic process (GO:0042402)2.19604047
166ATP synthesis coupled proton transport (GO:0015986)2.19597298
167energy coupled proton transport, down electrochemical gradient (GO:0015985)2.19597298
168cilium morphogenesis (GO:0060271)2.19218989
169response to pheromone (GO:0019236)2.17810585
170cell proliferation in forebrain (GO:0021846)2.17449511
171negative regulation of cytosolic calcium ion concentration (GO:0051481)2.17166279
172gamma-aminobutyric acid transport (GO:0015812)2.16683515
173regulation of mesoderm development (GO:2000380)2.16274181
174regulation of action potential (GO:0098900)2.15229545
175appendage development (GO:0048736)2.15147565
176limb development (GO:0060173)2.15147565
177cilium organization (GO:0044782)2.14365900
178detection of light stimulus involved in sensory perception (GO:0050962)2.12235817
179detection of light stimulus involved in visual perception (GO:0050908)2.12235817
180anterograde axon cargo transport (GO:0008089)2.11901662
181male meiosis I (GO:0007141)2.11050730
182nucleobase catabolic process (GO:0046113)2.10537264
183postreplication repair (GO:0006301)2.09904716
184protein neddylation (GO:0045116)2.09741891
185cilium assembly (GO:0042384)2.09652006
186anterograde synaptic vesicle transport (GO:0048490)2.09602339
187endoderm formation (GO:0001706)2.09512995
188postsynaptic membrane organization (GO:0001941)2.09399822
189spinal cord motor neuron differentiation (GO:0021522)2.08553323
190inner ear receptor stereocilium organization (GO:0060122)2.08528653
191centriole replication (GO:0007099)2.08197348
192DNA damage response, detection of DNA damage (GO:0042769)2.08172761
193regulation of telomere maintenance (GO:0032204)2.08132415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.16864388
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.76986543
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.60808006
4ZNF274_21170338_ChIP-Seq_K562_Hela3.41953538
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.18624101
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.17379741
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16331714
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97712608
9VDR_22108803_ChIP-Seq_LS180_Human2.85141394
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.80352957
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.61751259
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.56054579
13GBX2_23144817_ChIP-Seq_PC3_Human2.53997533
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50943632
15AR_21909140_ChIP-Seq_LNCAP_Human2.35476310
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35371703
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.35356088
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.32078152
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31638305
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.22096588
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21242221
22IGF1R_20145208_ChIP-Seq_DFB_Human2.17781731
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10003371
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02621810
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99110331
26SOX2_18555785_ChIP-Seq_MESCs_Mouse1.96856791
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96337136
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.93850539
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93327059
30TAF15_26573619_Chip-Seq_HEK293_Human1.89956755
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89148741
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85872763
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84456061
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84456061
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84456061
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80609460
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.78992748
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76883802
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75912693
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74779420
41ELK1_19687146_ChIP-ChIP_HELA_Human1.73918859
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71245024
43P300_19829295_ChIP-Seq_ESCs_Human1.68602426
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68350897
45MYC_18940864_ChIP-ChIP_HL60_Human1.67114789
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63552898
47ER_23166858_ChIP-Seq_MCF-7_Human1.61874075
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59064036
49IRF1_19129219_ChIP-ChIP_H3396_Human1.58986184
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.58367537
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.56872369
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55837355
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54879653
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54460095
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52544034
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52478189
57TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49551284
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48757208
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48591318
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48213223
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.46363634
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45586189
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42943215
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42738158
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41546203
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.40263704
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39587210
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38833148
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38363918
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.35968317
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35250014
72* STAT3_23295773_ChIP-Seq_U87_Human1.34943779
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.34323141
74* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34114394
75REST_21632747_ChIP-Seq_MESCs_Mouse1.32417848
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31381435
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31207840
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30573755
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30177843
80* SMAD4_21799915_ChIP-Seq_A2780_Human1.28435257
81TP53_22573176_ChIP-Seq_HFKS_Human1.28329592
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27277424
83CBP_20019798_ChIP-Seq_JUKART_Human1.27187208
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27187208
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26698513
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.26557961
87XRN2_22483619_ChIP-Seq_HELA_Human1.26539916
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.26348502
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25500170
90* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25178926
91AR_25329375_ChIP-Seq_VCAP_Human1.24948080
92TCF4_23295773_ChIP-Seq_U87_Human1.24215368
93TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.23705968
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23052190
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21839286
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21542243
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21484645
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.21107956
99TTF2_22483619_ChIP-Seq_HELA_Human1.20731879
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20710924
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20149418
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18919441
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18752870
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18735203
105BCAT_22108803_ChIP-Seq_LS180_Human1.17877729
106* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16868524
107EED_16625203_ChIP-ChIP_MESCs_Mouse1.16267359
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.15882070
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15373513
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15334214
111FUS_26573619_Chip-Seq_HEK293_Human1.14531512
112* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14061269
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13889244
114EGR1_19374776_ChIP-ChIP_THP-1_Human1.12892837
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11227180
116JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10653587
117RNF2_27304074_Chip-Seq_NSC_Mouse1.09656202
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09089713
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08776442
120PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08712703
121ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07789993
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06888416
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06888416
124RUNX2_22187159_ChIP-Seq_PCA_Human1.06542758
125* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05947953
126* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05681658
127* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05300511
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05295967
129VDR_23849224_ChIP-Seq_CD4+_Human1.04239398
130TCF4_22108803_ChIP-Seq_LS180_Human1.02812392
131STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01735243
132* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01505284
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01318020
134GATA1_26923725_Chip-Seq_HPCs_Mouse1.01162401
135NOTCH1_21737748_ChIP-Seq_TLL_Human1.00499137
136PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00470264
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98678631
138JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97915651
139CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97882876
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97431284
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97299440
142EZH2_22144423_ChIP-Seq_EOC_Human0.96925618
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96515755
144SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95987672
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95319352
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95244507
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95019198
148HOXB7_26014856_ChIP-Seq_BT474_Human0.94394614
149PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93594604
150NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93195107
151SOX2_19829295_ChIP-Seq_ESCs_Human0.92428060
152NANOG_19829295_ChIP-Seq_ESCs_Human0.92428060
153FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92427999
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92369655
155AR_21572438_ChIP-Seq_LNCaP_Human0.92118901
156JUN_21703547_ChIP-Seq_K562_Human0.92056224
157DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92048440
158EST1_17652178_ChIP-ChIP_JURKAT_Human0.91848439
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.91643857
160ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90949498
161PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90913684
162FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90782941
163FOXA1_25329375_ChIP-Seq_VCAP_Human0.90782941
164ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90441199
165PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89175658
166HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88302788
167PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88239654
168E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87822874
169EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87314007
170SOX9_26525672_Chip-Seq_HEART_Mouse0.86428641
171SOX17_20123909_ChIP-Seq_XEN_Mouse0.85191787
172WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84904089
173EWS_26573619_Chip-Seq_HEK293_Human0.84829591
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83888791
175SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83619096
176RING1B_27294783_Chip-Seq_NPCs_Mouse0.83379520
177TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82907559
178BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82454962
179EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82171788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.06041028
2MP0003123_paternal_imprinting2.79630229
3MP0002653_abnormal_ependyma_morphology2.53435724
4MP0008877_abnormal_DNA_methylation2.45934107
5MP0000537_abnormal_urethra_morphology2.44560104
6MP0003121_genomic_imprinting2.28887895
7MP0010094_abnormal_chromosome_stability2.25302183
8MP0003880_abnormal_central_pattern2.16014390
9MP0004957_abnormal_blastocyst_morpholog2.12775597
10MP0005623_abnormal_meninges_morphology2.12738180
11MP0003111_abnormal_nucleus_morphology2.12575434
12MP0009053_abnormal_anal_canal2.02793770
13MP0003077_abnormal_cell_cycle1.96793712
14MP0003119_abnormal_digestive_system1.94065630
15MP0000569_abnormal_digit_pigmentation1.91466147
16MP0001968_abnormal_touch/_nociception1.86609979
17MP0005551_abnormal_eye_electrophysiolog1.84175187
18MP0003942_abnormal_urinary_system1.84158602
19MP0002736_abnormal_nociception_after1.83693572
20MP0001529_abnormal_vocalization1.83535485
21MP0003937_abnormal_limbs/digits/tail_de1.82209440
22MP0003693_abnormal_embryo_hatching1.81505451
23MP0003705_abnormal_hypodermis_morpholog1.77794486
24MP0008932_abnormal_embryonic_tissue1.77588502
25MP0003122_maternal_imprinting1.75326675
26MP0000427_abnormal_hair_cycle1.72645737
27MP0003315_abnormal_perineum_morphology1.72496001
28MP0008007_abnormal_cellular_replicative1.71640846
29MP0003385_abnormal_body_wall1.69381313
30MP0009046_muscle_twitch1.67507707
31MP0002084_abnormal_developmental_patter1.66602649
32MP0002085_abnormal_embryonic_tissue1.65066307
33MP0004142_abnormal_muscle_tone1.64711963
34MP0003890_abnormal_embryonic-extraembry1.64687199
35MP0000534_abnormal_ureter_morphology1.64535426
36MP0006072_abnormal_retinal_apoptosis1.59529823
37MP0001730_embryonic_growth_arrest1.58981513
38MP0003567_abnormal_fetal_cardiomyocyte1.56797206
39MP0002249_abnormal_larynx_morphology1.55109623
40MP0000049_abnormal_middle_ear1.54619542
41MP0004197_abnormal_fetal_growth/weight/1.54121099
42MP0003755_abnormal_palate_morphology1.51275457
43MP0008789_abnormal_olfactory_epithelium1.49259702
44MP0003136_yellow_coat_color1.49166345
45MP0003941_abnormal_skin_development1.48529490
46MP0000631_abnormal_neuroendocrine_gland1.48450586
47MP0001697_abnormal_embryo_size1.48308031
48MP0003115_abnormal_respiratory_system1.47563676
49MP0005380_embryogenesis_phenotype1.45961527
50MP0001672_abnormal_embryogenesis/_devel1.45961527
51MP0006276_abnormal_autonomic_nervous1.45545258
52MP0009745_abnormal_behavioral_response1.43528732
53MP0000566_synostosis1.42835903
54MP0005248_abnormal_Harderian_gland1.40895332
55MP0005367_renal/urinary_system_phenotyp1.40878404
56MP0000516_abnormal_urinary_system1.40878404
57MP0001485_abnormal_pinna_reflex1.40607353
58MP0004233_abnormal_muscle_weight1.39354636
59MP0000350_abnormal_cell_proliferation1.37815477
60MP0002210_abnormal_sex_determination1.36902090
61MP0004272_abnormal_basement_membrane1.36552102
62MP0002735_abnormal_chemical_nociception1.35780319
63MP0003861_abnormal_nervous_system1.35387111
64MP0004147_increased_porphyrin_level1.34081829
65MP0008058_abnormal_DNA_repair1.33912183
66MP0002184_abnormal_innervation1.33429016
67MP0008057_abnormal_DNA_replication1.32836613
68MP0002282_abnormal_trachea_morphology1.29497230
69MP0002234_abnormal_pharynx_morphology1.28669077
70MP0005076_abnormal_cell_differentiation1.28532023
71MP0003935_abnormal_craniofacial_develop1.28208347
72MP0001293_anophthalmia1.27304255
73MP0003984_embryonic_growth_retardation1.27092162
74MP0000383_abnormal_hair_follicle1.27045346
75MP0009250_abnormal_appendicular_skeleto1.26695023
76MP0004885_abnormal_endolymph1.26567524
77MP0002088_abnormal_embryonic_growth/wei1.26121217
78MP0010386_abnormal_urinary_bladder1.24755200
79MP0005423_abnormal_somatic_nervous1.24468946
80MP0005646_abnormal_pituitary_gland1.24334025
81MP0002272_abnormal_nervous_system1.22530461
82MP0002557_abnormal_social/conspecific_i1.22318506
83MP0002932_abnormal_joint_morphology1.21610801
84MP0003787_abnormal_imprinting1.20799188
85MP0002233_abnormal_nose_morphology1.19345706
86MP0002102_abnormal_ear_morphology1.19217358
87MP0002116_abnormal_craniofacial_bone1.18945504
88MP0002111_abnormal_tail_morphology1.18064757
89MP0004133_heterotaxia1.17933459
90MP0005499_abnormal_olfactory_system1.17859873
91MP0005394_taste/olfaction_phenotype1.17859873
92MP0008872_abnormal_physiological_respon1.17711007
93MP0003718_maternal_effect1.15976156
94MP0002734_abnormal_mechanical_nocicepti1.15927631
95MP0000428_abnormal_craniofacial_morphol1.15453711
96MP0005253_abnormal_eye_physiology1.14999259
97MP0005187_abnormal_penis_morphology1.14821367
98MP0002697_abnormal_eye_size1.14157781
99MP0002837_dystrophic_cardiac_calcinosis1.13930317
100MP0001929_abnormal_gametogenesis1.13885752
101MP0000778_abnormal_nervous_system1.13686448
102MP0005645_abnormal_hypothalamus_physiol1.13059524
103MP0001286_abnormal_eye_development1.12495981
104MP0009379_abnormal_foot_pigmentation1.12328540
105MP0002086_abnormal_extraembryonic_tissu1.12096355
106MP0003950_abnormal_plasma_membrane1.11790527
107MP0000432_abnormal_head_morphology1.09515983
108MP0002572_abnormal_emotion/affect_behav1.08956044
109MP0001486_abnormal_startle_reflex1.08111454
110MP0002160_abnormal_reproductive_system1.07675749
111MP0002928_abnormal_bile_duct1.07445174
112MP0001145_abnormal_male_reproductive1.06932687
113MP0000653_abnormal_sex_gland1.06303650
114MP0002751_abnormal_autonomic_nervous1.05732581
115MP0005503_abnormal_tendon_morphology1.03742300
116MP0002752_abnormal_somatic_nervous1.03563119
117MP0005389_reproductive_system_phenotype1.02718422
118MP0010352_gastrointestinal_tract_polyps1.02489675
119MP0002080_prenatal_lethality1.01506090
120MP0003938_abnormal_ear_development1.01376187
121MP0005195_abnormal_posterior_eye1.01342396
122MP0004742_abnormal_vestibular_system1.01260213
123MP0002114_abnormal_axial_skeleton1.01102825
124MP0006292_abnormal_olfactory_placode1.00515397
125MP0004145_abnormal_muscle_electrophysio1.00470100
126MP0001915_intracranial_hemorrhage0.99867041
127MP0001849_ear_inflammation0.98029016
128MP0000026_abnormal_inner_ear0.97273164
129MP0009672_abnormal_birth_weight0.97264141
130MP0005386_behavior/neurological_phenoty0.97125927
131MP0004924_abnormal_behavior0.97125927
132MP0009384_cardiac_valve_regurgitation0.96870076
133MP0002163_abnormal_gland_morphology0.96841942
134MP0003698_abnormal_male_reproductive0.96140687
135MP0003635_abnormal_synaptic_transmissio0.95821929
136MP0002063_abnormal_learning/memory/cond0.94997859
137MP0005174_abnormal_tail_pigmentation0.93340369
138MP0000733_abnormal_muscle_development0.92727585
139MP0002067_abnormal_sensory_capabilities0.92537549
140MP0001986_abnormal_taste_sensitivity0.90857818
141MP0002733_abnormal_thermal_nociception0.90820174
142MP0000955_abnormal_spinal_cord0.90799399
143MP0002876_abnormal_thyroid_physiology0.90676059
144MP0009703_decreased_birth_body0.89757081
145MP0003011_delayed_dark_adaptation0.89614073
146MP0002092_abnormal_eye_morphology0.89043081
147MP0005508_abnormal_skeleton_morphology0.88995315
148MP0010307_abnormal_tumor_latency0.88613425
149MP0003195_calcinosis0.88589346
150MP0002938_white_spotting0.88236163
151MP0001970_abnormal_pain_threshold0.88008821
152MP0009697_abnormal_copulation0.87546124
153MP0002064_seizures0.85708099
154MP0002081_perinatal_lethality0.85264499
155MP0002882_abnormal_neuron_morphology0.84547819
156MP0000762_abnormal_tongue_morphology0.84538890
157MP0005084_abnormal_gallbladder_morpholo0.83501086
158MP0001119_abnormal_female_reproductive0.83349631
159MP0005391_vision/eye_phenotype0.82551324
160MP0000538_abnormal_urinary_bladder0.82549286
161MP0003283_abnormal_digestive_organ0.82526112
162MP0004043_abnormal_pH_regulation0.81529531
163MP0002161_abnormal_fertility/fecundity0.81150033
164MP0000647_abnormal_sebaceous_gland0.81001094

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)3.69733227
2Abnormality of midbrain morphology (HP:0002418)3.69733227
3Pancreatic cysts (HP:0001737)3.65108452
4True hermaphroditism (HP:0010459)3.55669352
5Pancreatic fibrosis (HP:0100732)3.52276509
6Type II lissencephaly (HP:0007260)3.12007616
7Nephronophthisis (HP:0000090)3.09494188
8Congenital stationary night blindness (HP:0007642)3.07848314
9Medial flaring of the eyebrow (HP:0010747)2.96137291
10Gait imbalance (HP:0002141)2.66661999
11Short 4th metacarpal (HP:0010044)2.64748717
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.64748717
13Abnormality of the renal medulla (HP:0100957)2.64036254
14Cerebellar dysplasia (HP:0007033)2.63638712
15Abnormality of the labia minora (HP:0012880)2.60914044
16Sclerocornea (HP:0000647)2.60888222
17Chronic hepatic failure (HP:0100626)2.59875697
18Hyperventilation (HP:0002883)2.56208141
19Abnormality of the renal cortex (HP:0011035)2.53887813
20Congenital primary aphakia (HP:0007707)2.52581721
21Abnormality of the anterior horn cell (HP:0006802)2.52362513
22Degeneration of anterior horn cells (HP:0002398)2.52362513
23Supernumerary spleens (HP:0009799)2.50760964
24Abnormal lung lobation (HP:0002101)2.49571193
25Pendular nystagmus (HP:0012043)2.48228496
26Shallow orbits (HP:0000586)2.44674892
27Astrocytoma (HP:0009592)2.44358647
28Abnormality of the astrocytes (HP:0100707)2.44358647
29Lissencephaly (HP:0001339)2.43237494
30Ependymoma (HP:0002888)2.40014599
31Cystic liver disease (HP:0006706)2.39057780
32Tubular atrophy (HP:0000092)2.38499020
33Rib fusion (HP:0000902)2.36739572
34Nephrogenic diabetes insipidus (HP:0009806)2.36511142
35Shawl scrotum (HP:0000049)2.36185708
36Patellar aplasia (HP:0006443)2.35665331
37Selective tooth agenesis (HP:0001592)2.33460522
38Embryonal renal neoplasm (HP:0011794)2.32968497
39Renal duplication (HP:0000075)2.32758580
40Aplasia/Hypoplasia of the patella (HP:0006498)2.32552237
41Hypoplasia of the pons (HP:0012110)2.31864174
42Genetic anticipation (HP:0003743)2.31152097
43Nephroblastoma (Wilms tumor) (HP:0002667)2.30590550
44Facial hemangioma (HP:0000329)2.28490821
45Volvulus (HP:0002580)2.25988323
46Medulloblastoma (HP:0002885)2.21585439
47Abnormality of the pons (HP:0007361)2.20879134
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.20590967
49Vaginal atresia (HP:0000148)2.19348765
50Genital tract atresia (HP:0001827)2.19085778
51Increased corneal curvature (HP:0100692)2.18944417
52Keratoconus (HP:0000563)2.18944417
53Reticulocytopenia (HP:0001896)2.18829901
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.18626018
55Abnormality of the aortic arch (HP:0012303)2.15587222
56Ectopic kidney (HP:0000086)2.14843276
57Colon cancer (HP:0003003)2.14504233
58Concave nail (HP:0001598)2.13614331
59Male pseudohermaphroditism (HP:0000037)2.13203943
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11946284
61Abnormality of alanine metabolism (HP:0010916)2.11946284
62Hyperalaninemia (HP:0003348)2.11946284
63Birth length less than 3rd percentile (HP:0003561)2.11768951
64Short 1st metacarpal (HP:0010034)2.10858103
65Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.10858103
66Short humerus (HP:0005792)2.08025455
67Aplasia/hypoplasia of the humerus (HP:0006507)2.07127271
68Progressive cerebellar ataxia (HP:0002073)2.06297092
69Rhabdomyosarcoma (HP:0002859)2.06107916
70Abnormality of dentin (HP:0010299)2.05785221
71Absent radius (HP:0003974)2.04866578
72Abnormality of the phalanges of the hallux (HP:0010057)2.01737950
73Impulsivity (HP:0100710)2.01274944
74Abnormality of the 4th metacarpal (HP:0010012)2.00792451
75Anencephaly (HP:0002323)1.97707065
76Glioma (HP:0009733)1.97067177
77Absent thumb (HP:0009777)1.96942424
78Deviation of the thumb (HP:0009603)1.96554528
79Abnormality of the lower motor neuron (HP:0002366)1.96469515
80Bilateral microphthalmos (HP:0007633)1.95796792
81Bifid tongue (HP:0010297)1.94345938
82Poor coordination (HP:0002370)1.94279973
83Acute necrotizing encephalopathy (HP:0006965)1.94241285
84Aplasia involving forearm bones (HP:0009822)1.94100941
85Absent forearm bone (HP:0003953)1.94100941
86Abnormality of cells of the erythroid lineage (HP:0012130)1.94036631
87Abnormal number of erythroid precursors (HP:0012131)1.93629023
88Retinal dysplasia (HP:0007973)1.93284144
89Papillary thyroid carcinoma (HP:0002895)1.93275584
90Postaxial foot polydactyly (HP:0001830)1.92675402
91Increased nuchal translucency (HP:0010880)1.91216312
92Congenital, generalized hypertrichosis (HP:0004540)1.90171244
93Protrusio acetabuli (HP:0003179)1.89267490
94Breast hypoplasia (HP:0003187)1.88664610
95Microglossia (HP:0000171)1.88474077
96Acute encephalopathy (HP:0006846)1.88462035
97Wrist flexion contracture (HP:0001239)1.87780235
98Renal cortical cysts (HP:0000803)1.86588078
99Astigmatism (HP:0000483)1.86357131
100Midline defect of the nose (HP:0004122)1.86003350
101Missing ribs (HP:0000921)1.85773515
102Pachygyria (HP:0001302)1.84335965
103Chromsome breakage (HP:0040012)1.83925125
104Optic nerve hypoplasia (HP:0000609)1.83877691
105Proximal placement of thumb (HP:0009623)1.83437295
106Dandy-Walker malformation (HP:0001305)1.83088714
107High anterior hairline (HP:0009890)1.82117223
108Occipital encephalocele (HP:0002085)1.81606903
109Neoplasm of striated muscle (HP:0009728)1.81559437
110Abnormality of the 1st metacarpal (HP:0010009)1.81302189
111Abnormality of DNA repair (HP:0003254)1.80825474
112Short phalanx of the thumb (HP:0009660)1.79551907
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.79358470
114Aganglionic megacolon (HP:0002251)1.79178197
115Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79119189
116Broad-based gait (HP:0002136)1.78372360
117Preaxial hand polydactyly (HP:0001177)1.78250960
118Increased CSF lactate (HP:0002490)1.78147353
119Chorioretinal atrophy (HP:0000533)1.76058975
120Scrotal hypoplasia (HP:0000046)1.75466733
121Meckel diverticulum (HP:0002245)1.74491147
122Abnormal rod and cone electroretinograms (HP:0008323)1.74097842
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73639004
124Atresia of the external auditory canal (HP:0000413)1.73511542
125Preaxial foot polydactyly (HP:0001841)1.73136850
126Small hand (HP:0200055)1.71774841
127Narrow forehead (HP:0000341)1.71750641
128Abnormality of the carotid arteries (HP:0005344)1.71566286
129Facial cleft (HP:0002006)1.70998322
130Anophthalmia (HP:0000528)1.69974286
131Furrowed tongue (HP:0000221)1.69377715
132Bicornuate uterus (HP:0000813)1.68928915
133Postaxial hand polydactyly (HP:0001162)1.68757401
134Gastrointestinal carcinoma (HP:0002672)1.68755155
135Malignant gastrointestinal tract tumors (HP:0006749)1.68755155
136Oligodactyly (hands) (HP:0001180)1.68750622
137Inability to walk (HP:0002540)1.68315656
138Sloping forehead (HP:0000340)1.68196633
139Trigonocephaly (HP:0000243)1.68064021
140Mitochondrial inheritance (HP:0001427)1.67431735
141Intestinal polyp (HP:0005266)1.66262214
142Congenital hepatic fibrosis (HP:0002612)1.65553993
143Duodenal stenosis (HP:0100867)1.65432287
144Small intestinal stenosis (HP:0012848)1.65432287
145Severe muscular hypotonia (HP:0006829)1.65191996
146Oligodactyly (HP:0012165)1.65099880
147Broad thumb (HP:0011304)1.65093913
148Abnormality of the ileum (HP:0001549)1.65043316
149Hepatocellular necrosis (HP:0001404)1.64935943
150Abnormal number of incisors (HP:0011064)1.64011017
151Hypoplasia of the uterus (HP:0000013)1.63950243
152Intestinal polyposis (HP:0200008)1.63915906
153Abnormal mitochondria in muscle tissue (HP:0008316)1.63559743
154Gaze-evoked nystagmus (HP:0000640)1.62845710
155Attenuation of retinal blood vessels (HP:0007843)1.62581948
156Synostosis of carpal bones (HP:0005048)1.61978451
157Triphalangeal thumb (HP:0001199)1.61504286
158Abnormality of the preputium (HP:0100587)1.60842870
159Abnormal drinking behavior (HP:0030082)1.60600271
160Polydipsia (HP:0001959)1.60600271
161Broad phalanges of the hand (HP:0009768)1.60405058
162Disproportionate short-trunk short stature (HP:0003521)1.59914765
163Skull defect (HP:0001362)1.59477162
164Abnormality of the distal phalanx of the thumb (HP:0009617)1.58457410
165Asymmetry of the thorax (HP:0001555)1.58077373
166Aplasia/Hypoplasia of the uvula (HP:0010293)1.58037123
167Renal hypoplasia (HP:0000089)1.56750046
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.56546204
169Breast aplasia (HP:0100783)1.55126214
170Morphological abnormality of the middle ear (HP:0008609)1.55105587
171Broad finger (HP:0001500)1.54743320
172Shoulder girdle muscle weakness (HP:0003547)1.54441126
173Abnormal ventriculo-arterial connection (HP:0011563)1.53294480
174Transposition of the great arteries (HP:0001669)1.53294480
175Abnormal connection of the cardiac segments (HP:0011545)1.53294480
176Absent eyebrow (HP:0002223)1.53227776
177Carpal synostosis (HP:0009702)1.52697165
178Male infertility (HP:0003251)1.51615945
179Abdominal situs inversus (HP:0003363)1.50937120
180Abnormality of abdominal situs (HP:0011620)1.50937120
181Aplasia/Hypoplasia of the breasts (HP:0010311)1.50928370
182Esophageal atresia (HP:0002032)1.50927972
183Pseudobulbar signs (HP:0002200)1.49811441
184Abnormality of chromosome segregation (HP:0002916)1.49716073
185Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.49485605
186Diastasis recti (HP:0001540)1.49446067
187Vertebral fusion (HP:0002948)1.48406639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.02342463
2CDC73.43905290
3LATS23.32887314
4BMPR1B3.13373310
5LATS12.60663086
6STK38L2.58328148
7WNK42.51388720
8TTK2.44786266
9CDK122.37486860
10AKT32.33223848
11CASK2.32476095
12NEK22.21692093
13ADRBK22.14850381
14BUB12.10402908
15WNK32.09890982
16STK392.06734338
17NEK12.02458771
18GRK11.94077981
19PLK41.88417825
20MKNK11.87239498
21SRPK11.84656634
22TLK11.81452892
23WEE11.79055457
24INSRR1.77449361
25PLK31.71842124
26PLK11.67514316
27VRK21.66106172
28KSR11.64240611
29TNIK1.61416102
30MAP4K21.60321096
31EPHB21.59264183
32OXSR11.58741867
33TRIM281.53935898
34TAF11.53437313
35PASK1.53201143
36PRKD31.47685081
37PLK21.46713424
38BRAF1.45724549
39PINK11.43964354
40CHEK21.43899953
41EPHA21.42539935
42TYRO31.39869164
43ERBB31.32977876
44EEF2K1.25372137
45MKNK21.25124120
46ICK1.23183444
47PNCK1.21350685
48BCR1.19380095
49CDK81.17911843
50TSSK61.16817502
51PDGFRA1.16176212
52MAP2K71.13968791
53ERBB41.11910274
54PAK31.11576507
55PDK31.10790939
56PDK41.10790939
57STK31.10679290
58AURKA1.10434589
59CHEK11.08456835
60MELK1.08232516
61EIF2AK31.07889350
62PRKCG1.00574783
63CDK190.98104556
64VRK10.97849233
65PAK40.97267359
66DDR20.95638580
67AURKB0.95234536
68STK160.94154346
69SCYL20.93908456
70TESK10.93754197
71CDK70.92955910
72PKN20.92051606
73DYRK20.91439273
74NTRK30.91230713
75FLT30.89264555
76ADRBK10.87758451
77MAP3K40.86396708
78PAK60.86264389
79ATR0.83566599
80NME10.83227063
81EPHA40.83072842
82BRSK10.82638499
83FGFR10.82154936
84ATM0.81875228
85MTOR0.81789903
86RPS6KB20.81285085
87MARK10.80068540
88MOS0.80044292
89CDK20.77701114
90TGFBR10.77277770
91MST40.76028716
92BRD40.75775188
93MAP3K80.75537164
94PDK20.75510777
95FER0.74262841
96TIE10.74219233
97CDK10.73782311
98PRKCE0.73458165
99CSNK1G10.73194020
100CSNK1G20.72047100
101CAMKK20.70291853
102PBK0.66680154
103EIF2AK10.65251772
104SIK20.64734898
105BRSK20.64306387
106PTK20.64197099
107MAPKAPK50.64177719
108MAP3K120.63842321
109KSR20.63075520
110TAOK30.61638360
111PAK10.61332536
112MAP3K60.60568972
113CDK60.60057569
114MAPK130.59764255
115CDK180.59635827
116MAP3K100.59271498
117LIMK10.58953635
118CSNK1G30.58737497
119CDK140.58699883
120PHKG20.57651479
121PHKG10.57651479
122MINK10.57186665
123CDK40.57053309
124MAP3K90.56827140
125CSNK1E0.55881995
126NUAK10.55824103
127PAK20.55187266
128CDK150.54860726
129ACVR1B0.53231708
130BMPR20.52856973
131PRKCI0.52483924
132ZAK0.52215842
133STK380.52115132
134CSNK1A1L0.52112868
135CAMK1G0.51201386
136PIK3CA0.50026659
137CCNB10.49904414
138PTK2B0.48777528
139PRPF4B0.48603139
140ROCK10.46846711
141MET0.46569662
142CDK11A0.45132344
143CDK90.44568722
144NTRK20.43680289
145FGFR20.43047598
146CSNK1A10.41253029
147CSNK1D0.39863338
148SGK20.38795568
149AKT20.37893111
150CAMK2A0.37179479
151DAPK20.33196752

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.98318688
2RNA transport_Homo sapiens_hsa030132.90926912
3Protein export_Homo sapiens_hsa030602.86197089
4mRNA surveillance pathway_Homo sapiens_hsa030152.71726629
5Basal cell carcinoma_Homo sapiens_hsa052172.39951767
6Spliceosome_Homo sapiens_hsa030402.39931522
7Mismatch repair_Homo sapiens_hsa034302.38857710
8Hippo signaling pathway_Homo sapiens_hsa043902.36291170
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32610104
10DNA replication_Homo sapiens_hsa030302.26511746
11Oxidative phosphorylation_Homo sapiens_hsa001902.25833560
12Oocyte meiosis_Homo sapiens_hsa041142.24328200
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20192561
14Hedgehog signaling pathway_Homo sapiens_hsa043402.15481093
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14507592
16Ribosome_Homo sapiens_hsa030102.10604041
17Nicotine addiction_Homo sapiens_hsa050332.07225601
18Phototransduction_Homo sapiens_hsa047441.98352444
19Basal transcription factors_Homo sapiens_hsa030221.97299675
20Parkinsons disease_Homo sapiens_hsa050121.88415346
21Fanconi anemia pathway_Homo sapiens_hsa034601.86031991
22Adherens junction_Homo sapiens_hsa045201.81248359
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.80915169
24Base excision repair_Homo sapiens_hsa034101.76951754
25RNA degradation_Homo sapiens_hsa030181.76562454
26Butanoate metabolism_Homo sapiens_hsa006501.76330432
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74232974
28Nucleotide excision repair_Homo sapiens_hsa034201.72935849
29Selenocompound metabolism_Homo sapiens_hsa004501.71653639
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70857435
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68382439
32Homologous recombination_Homo sapiens_hsa034401.67794637
33TGF-beta signaling pathway_Homo sapiens_hsa043501.65332379
34MicroRNAs in cancer_Homo sapiens_hsa052061.61969093
35One carbon pool by folate_Homo sapiens_hsa006701.59095103
36RNA polymerase_Homo sapiens_hsa030201.49758838
37Wnt signaling pathway_Homo sapiens_hsa043101.48875558
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46117417
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45764310
40Linoleic acid metabolism_Homo sapiens_hsa005911.45213199
41Tight junction_Homo sapiens_hsa045301.43536538
42p53 signaling pathway_Homo sapiens_hsa041151.42224268
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.41423159
44Propanoate metabolism_Homo sapiens_hsa006401.41265203
45Nitrogen metabolism_Homo sapiens_hsa009101.40707310
46Non-homologous end-joining_Homo sapiens_hsa034501.40577908
47Colorectal cancer_Homo sapiens_hsa052101.39481037
48Cardiac muscle contraction_Homo sapiens_hsa042601.38321746
49Endometrial cancer_Homo sapiens_hsa052131.38012859
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37260273
51Thyroid cancer_Homo sapiens_hsa052161.37121864
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36843704
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35770414
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33437975
55Alzheimers disease_Homo sapiens_hsa050101.28741717
56Axon guidance_Homo sapiens_hsa043601.26439219
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25090310
58Taste transduction_Homo sapiens_hsa047421.23058129
59Steroid biosynthesis_Homo sapiens_hsa001001.19721793
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16855714
61Ether lipid metabolism_Homo sapiens_hsa005651.16018440
62Melanogenesis_Homo sapiens_hsa049161.14398701
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14253260
64Bladder cancer_Homo sapiens_hsa052191.11884217
65Tryptophan metabolism_Homo sapiens_hsa003801.11492725
66Small cell lung cancer_Homo sapiens_hsa052221.07439818
67Melanoma_Homo sapiens_hsa052181.05594216
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01021817
69Morphine addiction_Homo sapiens_hsa050320.99395308
70mTOR signaling pathway_Homo sapiens_hsa041500.99314195
71HTLV-I infection_Homo sapiens_hsa051660.98862160
72Proteoglycans in cancer_Homo sapiens_hsa052050.97282714
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95843953
74Notch signaling pathway_Homo sapiens_hsa043300.95515389
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.95230650
76Proteasome_Homo sapiens_hsa030500.94218170
77Alcoholism_Homo sapiens_hsa050340.91984963
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91467581
79Focal adhesion_Homo sapiens_hsa045100.90908832
80GABAergic synapse_Homo sapiens_hsa047270.90905462
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90874565
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90349293
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89520410
84Pathways in cancer_Homo sapiens_hsa052000.88979851
85Viral carcinogenesis_Homo sapiens_hsa052030.87715325
86Prostate cancer_Homo sapiens_hsa052150.87208223
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86076198
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85633505
89Pyrimidine metabolism_Homo sapiens_hsa002400.85277821
90Glioma_Homo sapiens_hsa052140.85053655
91ECM-receptor interaction_Homo sapiens_hsa045120.83560007
92Caffeine metabolism_Homo sapiens_hsa002320.82894637
93Insulin secretion_Homo sapiens_hsa049110.82103012
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.82047147
95Systemic lupus erythematosus_Homo sapiens_hsa053220.81443356
96Glutamatergic synapse_Homo sapiens_hsa047240.80576081
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80112212
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79116055
99Dorso-ventral axis formation_Homo sapiens_hsa043200.78506997
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75476668
101Sulfur relay system_Homo sapiens_hsa041220.73155202
102Gap junction_Homo sapiens_hsa045400.72603424
103ErbB signaling pathway_Homo sapiens_hsa040120.72404070
104Estrogen signaling pathway_Homo sapiens_hsa049150.71523344
105Serotonergic synapse_Homo sapiens_hsa047260.68877084
106Chronic myeloid leukemia_Homo sapiens_hsa052200.68454468
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.68332276
108beta-Alanine metabolism_Homo sapiens_hsa004100.67156703
109Long-term potentiation_Homo sapiens_hsa047200.66233765
110Renal cell carcinoma_Homo sapiens_hsa052110.65870924
111Epstein-Barr virus infection_Homo sapiens_hsa051690.65791936
112Metabolic pathways_Homo sapiens_hsa011000.65604691
113Purine metabolism_Homo sapiens_hsa002300.65301856
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.63344398
115N-Glycan biosynthesis_Homo sapiens_hsa005100.62344008
116ABC transporters_Homo sapiens_hsa020100.62343434
117Non-small cell lung cancer_Homo sapiens_hsa052230.60186634
118Peroxisome_Homo sapiens_hsa041460.60176857
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60151223
120Pancreatic cancer_Homo sapiens_hsa052120.59820063
121Circadian entrainment_Homo sapiens_hsa047130.58951782
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58850197
123Rap1 signaling pathway_Homo sapiens_hsa040150.58745607
124Dopaminergic synapse_Homo sapiens_hsa047280.58270843
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57551277
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57550741
127Chemical carcinogenesis_Homo sapiens_hsa052040.57325490
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56913350
129Glucagon signaling pathway_Homo sapiens_hsa049220.56851693
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55298212
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55221496
132Cocaine addiction_Homo sapiens_hsa050300.54438132
133Dilated cardiomyopathy_Homo sapiens_hsa054140.54395068
134Sulfur metabolism_Homo sapiens_hsa009200.53769726
135FoxO signaling pathway_Homo sapiens_hsa040680.52399414
136Regulation of autophagy_Homo sapiens_hsa041400.52337212
137HIF-1 signaling pathway_Homo sapiens_hsa040660.52131296
138GnRH signaling pathway_Homo sapiens_hsa049120.51746488
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51216405
140Fat digestion and absorption_Homo sapiens_hsa049750.50926561
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49599684
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48123727
143Ovarian steroidogenesis_Homo sapiens_hsa049130.47515133
144Oxytocin signaling pathway_Homo sapiens_hsa049210.47354695
145Long-term depression_Homo sapiens_hsa047300.47130873
146Biosynthesis of amino acids_Homo sapiens_hsa012300.46933812
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.46435273
148AMPK signaling pathway_Homo sapiens_hsa041520.44429569
149Lysine degradation_Homo sapiens_hsa003100.44188430
150Huntingtons disease_Homo sapiens_hsa050160.43569098
151Vitamin B6 metabolism_Homo sapiens_hsa007500.43359190
152Amphetamine addiction_Homo sapiens_hsa050310.42490606
153Calcium signaling pathway_Homo sapiens_hsa040200.42000635
154Glutathione metabolism_Homo sapiens_hsa004800.41900353
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40499981
156Retinol metabolism_Homo sapiens_hsa008300.40107097
157Ras signaling pathway_Homo sapiens_hsa040140.39707001
158Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38857232
159Cholinergic synapse_Homo sapiens_hsa047250.37770534
160Olfactory transduction_Homo sapiens_hsa047400.37527645
161cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36077735
162VEGF signaling pathway_Homo sapiens_hsa043700.34991160
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34905940
164Insulin signaling pathway_Homo sapiens_hsa049100.32829525
165Prion diseases_Homo sapiens_hsa050200.31930753
166Viral myocarditis_Homo sapiens_hsa054160.31309407

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