SPATA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microtubule depolymerization (GO:0007019)9.68860693
2acrosome reaction (GO:0007340)8.02896976
3sperm motility (GO:0030317)6.86405009
4fusion of sperm to egg plasma membrane (GO:0007342)6.78058281
5microtubule polymerization or depolymerization (GO:0031109)6.52546477
6kinetochore organization (GO:0051383)6.37685521
7chromosome condensation (GO:0030261)6.34745042
8spermatid nucleus differentiation (GO:0007289)6.10694092
9spermatid development (GO:0007286)6.03006580
10DNA packaging (GO:0006323)5.91718427
11head development (GO:0060322)5.75865700
12multicellular organism reproduction (GO:0032504)5.62670201
13response to pheromone (GO:0019236)5.47756393
14kinetochore assembly (GO:0051382)5.39771459
15behavioral response to nicotine (GO:0035095)5.25324822
16plasma membrane fusion (GO:0045026)5.01720815
17synaptic transmission, cholinergic (GO:0007271)4.97679298
18sperm-egg recognition (GO:0035036)4.94934761
19histone exchange (GO:0043486)4.91958694
20axonemal dynein complex assembly (GO:0070286)4.65586335
21lateral sprouting from an epithelium (GO:0060601)4.60865023
22monoubiquitinated protein deubiquitination (GO:0035520)4.59017289
23positive regulation of T cell differentiation in thymus (GO:0033089)4.56076405
24positive regulation of glomerulus development (GO:0090193)4.55056688
25binding of sperm to zona pellucida (GO:0007339)4.37040244
26reproduction (GO:0000003)4.36930120
27cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.31551821
28acrosome assembly (GO:0001675)4.28555993
29thalamus development (GO:0021794)4.25242144
30single strand break repair (GO:0000012)4.22812530
31sperm capacitation (GO:0048240)4.22636832
32RNA destabilization (GO:0050779)4.22293092
33regulation of cilium movement (GO:0003352)4.18014133
34cell-cell recognition (GO:0009988)4.07524712
35resolution of meiotic recombination intermediates (GO:0000712)4.05511796
36cilium or flagellum-dependent cell motility (GO:0001539)4.01715124
37calcium ion-dependent exocytosis (GO:0017156)4.01057872
38centriole replication (GO:0007099)3.96922155
39cellular response to virus (GO:0098586)3.94582082
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90106832
41polyamine biosynthetic process (GO:0006596)3.88541404
42male meiosis (GO:0007140)3.88410040
43cellular biogenic amine biosynthetic process (GO:0042401)3.84430362
44histone mRNA catabolic process (GO:0071044)3.82102311
45cranial nerve morphogenesis (GO:0021602)3.74178907
46startle response (GO:0001964)3.69065257
47epithelial cilium movement (GO:0003351)3.66384667
48amine biosynthetic process (GO:0009309)3.61108037
49meiotic chromosome segregation (GO:0045132)3.56925654
50DNA strand renaturation (GO:0000733)3.54461411
51central nervous system projection neuron axonogenesis (GO:0021952)3.54299967
52mitotic chromosome condensation (GO:0007076)3.53631769
53midbrain development (GO:0030901)3.51889871
54motile cilium assembly (GO:0044458)3.48697927
55N-terminal protein amino acid acetylation (GO:0006474)3.48559242
56response to follicle-stimulating hormone (GO:0032354)3.48335425
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44250066
58hindbrain development (GO:0030902)3.42622617
59CENP-A containing nucleosome assembly (GO:0034080)3.40719136
60chromatin remodeling at centromere (GO:0031055)3.38599104
61protein targeting to Golgi (GO:0000042)3.38278278
62protein depolymerization (GO:0051261)3.36720916
63male gamete generation (GO:0048232)3.35484870
64spermatogenesis (GO:0007283)3.35007043
65regulation of phosphoprotein phosphatase activity (GO:0043666)3.34728285
66tongue development (GO:0043586)3.34359100
67centriole assembly (GO:0098534)3.32618969
68establishment of protein localization to Golgi (GO:0072600)3.27295967
69single fertilization (GO:0007338)3.22626742
70Golgi to endosome transport (GO:0006895)3.22055482
71germ cell development (GO:0007281)3.21744197
72cilium movement (GO:0003341)3.21284337
73peptidyl-threonine dephosphorylation (GO:0035970)3.16091166
74chromosome organization involved in meiosis (GO:0070192)3.15940179
75mitotic metaphase plate congression (GO:0007080)3.13890930
76cell proliferation involved in kidney development (GO:0072111)3.12824498
77gamete generation (GO:0007276)3.09813263
78protein K6-linked ubiquitination (GO:0085020)3.09647863
79dendritic spine morphogenesis (GO:0060997)3.08069597
80meiotic nuclear division (GO:0007126)3.07790597
81retrograde transport, vesicle recycling within Golgi (GO:0000301)3.07059224
82cochlea morphogenesis (GO:0090103)3.03407170
83regulation of glomerulus development (GO:0090192)3.02810481
84regulation of transcription involved in cell fate commitment (GO:0060850)3.01913433
85anatomical structure regression (GO:0060033)2.98490913
86transmission of nerve impulse (GO:0019226)2.97324845
87male sex determination (GO:0030238)2.95937632
88positive regulation of Rab GTPase activity (GO:0032851)2.95219457
89regulation of Rab GTPase activity (GO:0032313)2.95219457
90cellular process involved in reproduction in multicellular organism (GO:0022412)2.95203443
91regulation of dopamine secretion (GO:0014059)2.94292819
92sister chromatid segregation (GO:0000819)2.93340412
93genitalia morphogenesis (GO:0035112)2.91500473
94regulation of cell proliferation involved in kidney development (GO:1901722)2.91315237
95DNA demethylation (GO:0080111)2.87719122
96negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.87494619
97regulation of microtubule-based movement (GO:0060632)2.87336178
98embryonic digestive tract development (GO:0048566)2.87279564
99phosphatidylethanolamine metabolic process (GO:0046337)2.86990419
100central nervous system neuron axonogenesis (GO:0021955)2.85738396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.78414296
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.55247347
3EZH2_22144423_ChIP-Seq_EOC_Human5.36300412
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.30207898
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.70020524
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.24123710
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.76879492
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.72687152
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.66779752
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44492561
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.31447732
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31447732
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.20384517
14CBP_20019798_ChIP-Seq_JUKART_Human2.20384517
15* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16162281
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15954018
17GBX2_23144817_ChIP-Seq_PC3_Human2.12654620
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.96202833
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.83321171
20* FUS_26573619_Chip-Seq_HEK293_Human1.75173397
21* ZNF274_21170338_ChIP-Seq_K562_Hela1.71722787
22IRF1_19129219_ChIP-ChIP_H3396_Human1.67885853
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67136034
24GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.64182184
25* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63675951
26ER_23166858_ChIP-Seq_MCF-7_Human1.55088403
27NANOG_20526341_ChIP-Seq_ESCs_Human1.54144723
28KLF5_20875108_ChIP-Seq_MESCs_Mouse1.48656237
29* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47818230
30ERG_20517297_ChIP-Seq_VCAP_Human1.46933927
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46722024
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.39564751
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39011153
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38928579
35BCAT_22108803_ChIP-Seq_LS180_Human1.38576187
36AR_21909140_ChIP-Seq_LNCAP_Human1.35189360
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31970375
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31570062
39TBL1_22424771_ChIP-Seq_293T_Human1.30866628
40TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30673125
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28557275
42P300_19829295_ChIP-Seq_ESCs_Human1.27442848
43* AR_25329375_ChIP-Seq_VCAP_Human1.25407328
44EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.25133718
45HOXB7_26014856_ChIP-Seq_BT474_Human1.23820245
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22252931
47MYC_19829295_ChIP-Seq_ESCs_Human1.20052426
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17929182
49TAF2_19829295_ChIP-Seq_ESCs_Human1.13733869
50ERA_21632823_ChIP-Seq_H3396_Human1.13092321
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.13088558
52SOX2_19829295_ChIP-Seq_ESCs_Human1.12830001
53NANOG_19829295_ChIP-Seq_ESCs_Human1.12830001
54LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12552862
55* RUNX2_22187159_ChIP-Seq_PCA_Human1.12123802
56NFYB_21822215_ChIP-Seq_K562_Human1.11991880
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.11042237
58OCT4_20526341_ChIP-Seq_ESCs_Human1.09970460
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08681055
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08200935
61TCF4_22108803_ChIP-Seq_LS180_Human1.08156703
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.07957779
63EWS_26573619_Chip-Seq_HEK293_Human1.07614317
64VDR_22108803_ChIP-Seq_LS180_Human1.06895493
65* OCT1_27270436_Chip-Seq_PROSTATE_Human1.06826424
66AR_21572438_ChIP-Seq_LNCaP_Human1.06726505
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06218046
68* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05672999
69NFYA_21822215_ChIP-Seq_K562_Human1.05383181
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05282683
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04354697
72SMAD4_21799915_ChIP-Seq_A2780_Human1.03814412
73GF1B_26923725_Chip-Seq_HPCs_Mouse1.01802057
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00616960
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00187394
76STAT3_23295773_ChIP-Seq_U87_Human0.98580783
77BCL6_27268052_Chip-Seq_Bcells_Human0.98411017
78BP1_19119308_ChIP-ChIP_Hs578T_Human0.98090131
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97873992
80TAF15_26573619_Chip-Seq_HEK293_Human0.97699272
81PHF8_20622853_ChIP-Seq_HELA_Human0.97391952
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.95944119
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95628670
84CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95113928
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94304674
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94128572
87E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94059515
88TP53_18474530_ChIP-ChIP_U2OS_Human0.93426998
89NCOR_22424771_ChIP-Seq_293T_Human0.93182541
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92827586
91TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92188170
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91805543
93CTCF_27219007_Chip-Seq_Bcells_Human0.91562405
94HTT_18923047_ChIP-ChIP_STHdh_Human0.90004577
95TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88987513
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.88394941
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87536884
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.87083670
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86628471
100ETV1_20927104_ChIP-Seq_GIST48_Human0.86297099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.36462936
2MP0005646_abnormal_pituitary_gland4.07523666
3MP0001485_abnormal_pinna_reflex3.27711651
4MP0002653_abnormal_ependyma_morphology3.20636785
5MP0002102_abnormal_ear_morphology3.19806911
6MP0003698_abnormal_male_reproductive3.00997901
7MP0006292_abnormal_olfactory_placode2.98898278
8MP0001929_abnormal_gametogenesis2.85638134
9MP0000049_abnormal_middle_ear2.82572022
10MP0008789_abnormal_olfactory_epithelium2.61730248
11MP0005499_abnormal_olfactory_system2.48100942
12MP0005394_taste/olfaction_phenotype2.48100942
13MP0003878_abnormal_ear_physiology2.38244405
14MP0005377_hearing/vestibular/ear_phenot2.38244405
15MP0009697_abnormal_copulation2.36146753
16MP0004742_abnormal_vestibular_system2.29736874
17MP0010030_abnormal_orbit_morphology2.22958306
18MP0000631_abnormal_neuroendocrine_gland2.20950694
19MP0003315_abnormal_perineum_morphology2.16354083
20MP0005248_abnormal_Harderian_gland2.16238483
21MP0002210_abnormal_sex_determination2.13414094
22MP0001486_abnormal_startle_reflex2.05168265
23MP0005670_abnormal_white_adipose2.05096818
24MP0008877_abnormal_DNA_methylation2.01695387
25MP0004885_abnormal_endolymph1.94429699
26MP0003787_abnormal_imprinting1.70199960
27MP0002234_abnormal_pharynx_morphology1.69982287
28MP0008004_abnormal_stomach_pH1.69926114
29MP0000653_abnormal_sex_gland1.66830340
30MP0001145_abnormal_male_reproductive1.63023258
31MP0002161_abnormal_fertility/fecundity1.57364706
32MP0000026_abnormal_inner_ear1.55905865
33MP0008569_lethality_at_weaning1.47189951
34MP0005389_reproductive_system_phenotype1.39346818
35MP0009780_abnormal_chondrocyte_physiolo1.37577668
36MP0001963_abnormal_hearing_physiology1.37369777
37MP0001764_abnormal_homeostasis1.35550351
38MP0002160_abnormal_reproductive_system1.33531568
39MP0008872_abnormal_physiological_respon1.31181071
40MP0001905_abnormal_dopamine_level1.28993257
41MP0001293_anophthalmia1.28699160
42MP0000778_abnormal_nervous_system1.27141172
43MP0005391_vision/eye_phenotype1.26541951
44MP0002092_abnormal_eye_morphology1.26536684
45MP0005551_abnormal_eye_electrophysiolog1.23570163
46MP0006276_abnormal_autonomic_nervous1.22284171
47MP0000569_abnormal_digit_pigmentation1.19395646
48MP0002132_abnormal_respiratory_system1.18751363
49MP0001270_distended_abdomen1.18183512
50MP0001919_abnormal_reproductive_system1.12979127
51MP0001984_abnormal_olfaction1.10115908
52MP0003718_maternal_effect1.09096603
53MP0003879_abnormal_hair_cell1.07329190
54MP0000566_synostosis1.05708719
55MP0009745_abnormal_behavioral_response1.05064447
56MP0003111_abnormal_nucleus_morphology1.02506788
57MP0002697_abnormal_eye_size1.02448729
58MP0002090_abnormal_vision0.98716108
59MP0005253_abnormal_eye_physiology0.98155910
60MP0002272_abnormal_nervous_system0.97166257
61MP0008995_early_reproductive_senescence0.96797925
62MP0002557_abnormal_social/conspecific_i0.92221890
63MP0002233_abnormal_nose_morphology0.91367928
64MP0010094_abnormal_chromosome_stability0.90065747
65MP0003755_abnormal_palate_morphology0.89431615
66MP0003938_abnormal_ear_development0.89012609
67MP0002572_abnormal_emotion/affect_behav0.88847305
68MP0002064_seizures0.86744532
69MP0002184_abnormal_innervation0.84088264
70MP0003121_genomic_imprinting0.82751739
71MP0000343_altered_response_to0.81603928
72MP0005395_other_phenotype0.81296588
73MP0002876_abnormal_thyroid_physiology0.80745617
74MP0003077_abnormal_cell_cycle0.80162454
75MP0002736_abnormal_nociception_after0.78126882
76MP0001348_abnormal_lacrimal_gland0.76130532
77MP0002067_abnormal_sensory_capabilities0.75568924
78MP0001119_abnormal_female_reproductive0.75195010
79MP0002116_abnormal_craniofacial_bone0.74527232
80MP0003861_abnormal_nervous_system0.74229656
81MP0005195_abnormal_posterior_eye0.73137503
82MP0009765_abnormal_xenobiotic_induced0.72185738
83MP0001661_extended_life_span0.71927586
84MP0003122_maternal_imprinting0.71638679
85MP0005174_abnormal_tail_pigmentation0.69517646
86MP0001346_abnormal_lacrimal_gland0.69460880
87MP0002168_other_aberrant_phenotype0.69226557
88MP0002752_abnormal_somatic_nervous0.69129559
89MP0002928_abnormal_bile_duct0.64466818
90MP0004085_abnormal_heartbeat0.62801993
91MP0003183_abnormal_peptide_metabolism0.62437654
92MP0001970_abnormal_pain_threshold0.61820464
93MP0005647_abnormal_sex_gland0.61185831
94MP0002063_abnormal_learning/memory/cond0.60483582
95MP0003937_abnormal_limbs/digits/tail_de0.58545697
96MP0002152_abnormal_brain_morphology0.58404288
97MP0001440_abnormal_grooming_behavior0.58118098
98MP0002822_catalepsy0.56949904
99MP0002751_abnormal_autonomic_nervous0.56633925
100MP0004142_abnormal_muscle_tone0.56125223

Predicted human phenotypes

RankGene SetZ-score
1Optic nerve hypoplasia (HP:0000609)5.17020261
2Hypoplastic pelvis (HP:0008839)4.79189492
3Facial hemangioma (HP:0000329)4.62543683
4Aplasia/Hypoplasia of the optic nerve (HP:0008058)4.39697630
5Abnormal number of incisors (HP:0011064)4.38469617
6Hepatoblastoma (HP:0002884)3.97789746
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.84564917
8Chronic hepatic failure (HP:0100626)3.83916426
9Severe Myopia (HP:0011003)3.74894528
10Partial agenesis of the corpus callosum (HP:0001338)3.60315570
11Oligodactyly (hands) (HP:0001180)3.48855703
12Ectopic kidney (HP:0000086)3.46169796
13Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.41925812
14Anophthalmia (HP:0000528)3.40441380
15True hermaphroditism (HP:0010459)3.26808084
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.08727533
17Absent/shortened dynein arms (HP:0200106)3.08727533
18Abnormal sex determination (HP:0012244)3.06033938
19Sex reversal (HP:0012245)3.06033938
20Abnormality of the labia minora (HP:0012880)3.05809485
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.04844725
22Absent epiphyses (HP:0010577)3.04844725
23Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.03961367
24Oligodactyly (HP:0012165)3.01192104
25Hypoplastic ischia (HP:0003175)2.99733932
26Growth hormone deficiency (HP:0000824)2.99341390
27Increased density of long bones (HP:0006392)2.98336863
28Abnormal respiratory motile cilium morphology (HP:0005938)2.97939600
29Abnormal respiratory epithelium morphology (HP:0012253)2.97939600
30Abnormal ciliary motility (HP:0012262)2.93670266
31Hypoplastic female external genitalia (HP:0012815)2.75012931
32Selective tooth agenesis (HP:0001592)2.73386582
33Volvulus (HP:0002580)2.64571595
34Resting tremor (HP:0002322)2.63323909
35Severe visual impairment (HP:0001141)2.60449878
36Abnormal respiratory motile cilium physiology (HP:0012261)2.57755933
37Male pseudohermaphroditism (HP:0000037)2.48850015
38Abnormality of the ischium (HP:0003174)2.47578777
39Aplasia/Hypoplasia of the sternum (HP:0006714)2.45027674
40Abnormality of macular pigmentation (HP:0008002)2.43475892
41Ulnar claw (HP:0001178)2.42327570
42Abnormal spermatogenesis (HP:0008669)2.36434667
43Pancreatic fibrosis (HP:0100732)2.35877183
44Abnormality of midbrain morphology (HP:0002418)2.35540717
45Molar tooth sign on MRI (HP:0002419)2.35540717
46Pancreatic cysts (HP:0001737)2.33990464
47Abnormality of lateral ventricle (HP:0030047)2.33163530
48Ileus (HP:0002595)2.31306655
49Sclerocornea (HP:0000647)2.29380293
50Abnormality of the renal medulla (HP:0100957)2.27533619
51Decreased central vision (HP:0007663)2.27516686
52Occipital encephalocele (HP:0002085)2.27266899
53Abnormal rod and cone electroretinograms (HP:0008323)2.25637042
54Bony spicule pigmentary retinopathy (HP:0007737)2.23483721
55Nephronophthisis (HP:0000090)2.21496647
56Widely patent fontanelles and sutures (HP:0004492)2.20644745
57Congenital malformation of the right heart (HP:0011723)2.19132461
58Double outlet right ventricle (HP:0001719)2.19132461
59Flat capital femoral epiphysis (HP:0003370)2.18977700
60Septo-optic dysplasia (HP:0100842)2.18245050
61Abnormality of the incisor (HP:0000676)2.16954834
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15697966
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12481701
64Polydipsia (HP:0001959)2.12461126
65Abnormal drinking behavior (HP:0030082)2.12461126
66High anterior hairline (HP:0009890)2.12319516
67Attenuation of retinal blood vessels (HP:0007843)2.09161418
68Hypoplasia of the uterus (HP:0000013)2.09064533
69Polyuria (HP:0000103)2.07412996
70Abnormality of abdominal situs (HP:0011620)2.05588929
71Abdominal situs inversus (HP:0003363)2.05588929
72Congenital sensorineural hearing impairment (HP:0008527)2.01303791
73Hip dysplasia (HP:0001385)2.01080999
74Optic nerve coloboma (HP:0000588)2.01011461
75Hypophosphatemic rickets (HP:0004912)1.99128612
76Abnormal urine output (HP:0012590)1.99046824
77Dyschromatopsia (HP:0007641)1.98926935
78Central scotoma (HP:0000603)1.97118374
79Mutism (HP:0002300)1.96492016
80Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96002025
81Short 1st metacarpal (HP:0010034)1.96002025
82Germ cell neoplasia (HP:0100728)1.94747093
83Hydroureter (HP:0000072)1.93583175
84Decreased lacrimation (HP:0000633)1.92624458
85Focal seizures (HP:0007359)1.92541211
86Peripheral hypomyelination (HP:0007182)1.90662452
87Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.90425887
88Hyperthyroidism (HP:0000836)1.89834799
89Infertility (HP:0000789)1.86491471
90Hypomagnesemia (HP:0002917)1.86206363
91Intestinal atresia (HP:0011100)1.85121057
92Anencephaly (HP:0002323)1.84683810
93Cystic liver disease (HP:0006706)1.84229068
94Holoprosencephaly (HP:0001360)1.82594509
95Chorioretinal coloboma (HP:0000567)1.82297805
96Absent thumb (HP:0009777)1.82220007
97Long clavicles (HP:0000890)1.78452507
98Truncal obesity (HP:0001956)1.77502945
99Intellectual disability, moderate (HP:0002342)1.77479974
100Postaxial hand polydactyly (HP:0001162)1.76713048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE16.49717882
2PINK14.17184874
3TNIK3.68293645
4BRSK23.56719522
5MARK32.95110671
6DYRK22.49121046
7PKN12.45513813
8EPHB22.39868053
9STK392.39393777
10DDR22.30724816
11PLK42.29809174
12FRK2.21514682
13TLK12.05614364
14BRSK11.88457542
15CDC71.81674253
16MAP3K101.81621187
17CCNB11.75297066
18ZAK1.74591246
19PNCK1.74069590
20WNK41.62171746
21ERBB21.61737502
22CDK71.57219820
23STK38L1.52559667
24MAPK131.49727018
25DYRK31.45120873
26MYLK1.43897459
27DYRK1B1.38607664
28BUB11.37247410
29NEK21.31661855
30CAMK1G1.24791356
31MAPK151.22859346
32PLK21.19405959
33EIF2AK21.11644592
34KSR11.11046347
35ALK1.09136165
36LATS11.09030906
37INSRR1.08502336
38MAP3K81.06495340
39PLK31.04213521
40MARK21.03751831
41ROCK11.02995474
42CAMK10.98492587
43OXSR10.96877966
44TESK10.96239490
45NUAK10.93522278
46MAP2K70.84907062
47CASK0.80879046
48ICK0.78562284
49ADRBK20.77576160
50AURKB0.77440242
51FGFR20.77178656
52CAMK40.76911066
53RPS6KA50.76313848
54BCR0.75144343
55STK380.73463801
56PRKCG0.70810180
57NLK0.69163717
58STK30.66642762
59CDC42BPA0.65898048
60MAP3K70.65461576
61PAK30.55242406
62PIK3CG0.53672498
63PAK10.51421178
64TRIM280.49232641
65GRK10.48793439
66PLK10.48132000
67PASK0.47924370
68CDK20.42649329
69CAMK1D0.42544725
70BMPR1B0.42078156
71PTK2B0.41484552
72CHEK20.40187457
73MAPK100.40050526
74SGK2230.39054759
75SGK4940.39054759
76SIK20.38971533
77ERBB30.38151757
78FGR0.35659223
79CHEK10.34817291
80RPS6KA60.33975565
81MST1R0.33459548
82LIMK10.31731594
83PRKG10.29729406
84CDK10.29645176
85MINK10.29044975
86BMPR20.28737789
87ATM0.28695152
88PRKCQ0.26661708
89TIE10.23862509
90CDK140.23711930
91WNK30.22893613
92MAPK10.22127440
93CAMK2B0.21935998
94PRKCB0.21590884
95RPS6KC10.21510183
96RPS6KL10.21510183
97TGFBR10.21478204
98ATR0.20513278
99MARK10.19864625
100EPHA40.17951436

Predicted pathways (KEGG)

RankGene SetZ-score
1Hedgehog signaling pathway_Homo sapiens_hsa043403.84104893
2Fatty acid biosynthesis_Homo sapiens_hsa000613.55116154
3Nicotine addiction_Homo sapiens_hsa050333.30591745
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.26246133
5Olfactory transduction_Homo sapiens_hsa047402.87398628
6Gap junction_Homo sapiens_hsa045402.64240417
7Homologous recombination_Homo sapiens_hsa034402.61142218
8Butanoate metabolism_Homo sapiens_hsa006502.57744893
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.57072866
10Fanconi anemia pathway_Homo sapiens_hsa034602.33802378
11Basal cell carcinoma_Homo sapiens_hsa052172.27248904
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.17650299
13Phototransduction_Homo sapiens_hsa047442.13396527
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00893641
15Oocyte meiosis_Homo sapiens_hsa041141.95070227
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81053252
17Morphine addiction_Homo sapiens_hsa050321.71854510
18Basal transcription factors_Homo sapiens_hsa030221.60915635
19Nitrogen metabolism_Homo sapiens_hsa009101.55244814
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52061727
21p53 signaling pathway_Homo sapiens_hsa041151.50181103
22GABAergic synapse_Homo sapiens_hsa047271.45551238
23Fatty acid degradation_Homo sapiens_hsa000711.44451382
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39898450
25Serotonergic synapse_Homo sapiens_hsa047261.38104646
26Selenocompound metabolism_Homo sapiens_hsa004501.32573178
27Alcoholism_Homo sapiens_hsa050341.30194494
28Taste transduction_Homo sapiens_hsa047421.26589947
29Cell cycle_Homo sapiens_hsa041101.25208023
30Tyrosine metabolism_Homo sapiens_hsa003501.21367481
31Glutathione metabolism_Homo sapiens_hsa004801.20313135
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14967520
33Chemical carcinogenesis_Homo sapiens_hsa052041.14682872
34Circadian entrainment_Homo sapiens_hsa047131.12787506
35Hippo signaling pathway_Homo sapiens_hsa043901.06758163
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04466613
37Huntingtons disease_Homo sapiens_hsa050161.04199686
38Tryptophan metabolism_Homo sapiens_hsa003801.02266749
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98724251
40Purine metabolism_Homo sapiens_hsa002300.97510007
41Cardiac muscle contraction_Homo sapiens_hsa042600.96641664
42Systemic lupus erythematosus_Homo sapiens_hsa053220.93973316
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93003907
44Glycerolipid metabolism_Homo sapiens_hsa005610.92775414
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.89279485
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.84770738
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.81450041
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80786182
49Nucleotide excision repair_Homo sapiens_hsa034200.75980807
50Viral carcinogenesis_Homo sapiens_hsa052030.74461999
51Fatty acid metabolism_Homo sapiens_hsa012120.72047728
52Cholinergic synapse_Homo sapiens_hsa047250.69889191
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69782994
54PPAR signaling pathway_Homo sapiens_hsa033200.69537206
55RNA transport_Homo sapiens_hsa030130.64687521
56Linoleic acid metabolism_Homo sapiens_hsa005910.63913265
57Prostate cancer_Homo sapiens_hsa052150.63328178
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.62930913
59Dorso-ventral axis formation_Homo sapiens_hsa043200.60166206
60ECM-receptor interaction_Homo sapiens_hsa045120.59091483
61Calcium signaling pathway_Homo sapiens_hsa040200.58125630
62Endometrial cancer_Homo sapiens_hsa052130.55991811
63Retinol metabolism_Homo sapiens_hsa008300.55270141
64Oxytocin signaling pathway_Homo sapiens_hsa049210.54805125
65Tight junction_Homo sapiens_hsa045300.53083405
66Fat digestion and absorption_Homo sapiens_hsa049750.47534397
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47173798
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45960980
69Glutamatergic synapse_Homo sapiens_hsa047240.45875418
70Non-homologous end-joining_Homo sapiens_hsa034500.45660796
71Renin secretion_Homo sapiens_hsa049240.44067122
72Endocytosis_Homo sapiens_hsa041440.43829068
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42999623
74Platelet activation_Homo sapiens_hsa046110.42194148
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41377675
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40653631
77Synaptic vesicle cycle_Homo sapiens_hsa047210.40642709
78Ether lipid metabolism_Homo sapiens_hsa005650.39571572
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37916824
80Parkinsons disease_Homo sapiens_hsa050120.37769298
81Lysine degradation_Homo sapiens_hsa003100.37155877
82Mismatch repair_Homo sapiens_hsa034300.37137655
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35000232
84Choline metabolism in cancer_Homo sapiens_hsa052310.34688897
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34282780
86beta-Alanine metabolism_Homo sapiens_hsa004100.32598192
87Peroxisome_Homo sapiens_hsa041460.32597671
88Phagosome_Homo sapiens_hsa041450.32383327
89Folate biosynthesis_Homo sapiens_hsa007900.31773270
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31097614
91Wnt signaling pathway_Homo sapiens_hsa043100.29850027
92RNA degradation_Homo sapiens_hsa030180.29605129
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.29012434
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27680077
95Oxidative phosphorylation_Homo sapiens_hsa001900.27150590
96Metabolic pathways_Homo sapiens_hsa011000.27033729
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26604454
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26280085
99Apoptosis_Homo sapiens_hsa042100.23274673
100Arachidonic acid metabolism_Homo sapiens_hsa005900.22521364

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