SPATA5L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.48168297
2DNA topological change (GO:0006265)4.48433792
3DNA unwinding involved in DNA replication (GO:0006268)4.48359812
4protein localization to chromosome, centromeric region (GO:0071459)4.21286104
5folic acid-containing compound biosynthetic process (GO:0009396)4.20542752
6nuclear pore complex assembly (GO:0051292)4.17873596
7chromosome condensation (GO:0030261)4.09095137
8sister chromatid segregation (GO:0000819)4.04826424
9nuclear pore organization (GO:0006999)4.00909907
10CENP-A containing nucleosome assembly (GO:0034080)3.93732363
11mitotic metaphase plate congression (GO:0007080)3.93673783
12mitochondrial RNA metabolic process (GO:0000959)3.90536779
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.88750640
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.88750640
15mitotic sister chromatid segregation (GO:0000070)3.86696721
16chromatin remodeling at centromere (GO:0031055)3.84341590
17transcription from mitochondrial promoter (GO:0006390)3.82260939
18purine nucleotide salvage (GO:0032261)3.79730250
19homocysteine metabolic process (GO:0050667)3.71345225
20DNA packaging (GO:0006323)3.61940655
21V(D)J recombination (GO:0033151)3.61546931
22DNA strand elongation involved in DNA replication (GO:0006271)3.52547814
23IMP biosynthetic process (GO:0006188)3.52102015
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45417917
25DNA strand elongation (GO:0022616)3.41464573
26ribosome biogenesis (GO:0042254)3.40893339
27mitotic nuclear envelope disassembly (GO:0007077)3.40567580
28pore complex assembly (GO:0046931)3.37232996
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33699622
30DNA replication-independent nucleosome assembly (GO:0006336)3.30363417
31DNA replication-independent nucleosome organization (GO:0034724)3.30363417
32DNA ligation (GO:0006266)3.30147657
33mitotic recombination (GO:0006312)3.29313542
34telomere maintenance via semi-conservative replication (GO:0032201)3.27992433
35membrane disassembly (GO:0030397)3.21068707
36nuclear envelope disassembly (GO:0051081)3.21068707
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19185202
38DNA replication initiation (GO:0006270)3.18895578
39negative regulation of mRNA processing (GO:0050686)3.17348368
40IMP metabolic process (GO:0046040)3.15023572
41protein localization to kinetochore (GO:0034501)3.14699209
42kinetochore organization (GO:0051383)3.11061816
43negative regulation of RNA splicing (GO:0033119)3.10936395
44regulation of sister chromatid cohesion (GO:0007063)3.09578230
45mitotic sister chromatid cohesion (GO:0007064)3.07267613
46metaphase plate congression (GO:0051310)3.05848038
47histone exchange (GO:0043486)3.03868454
48regulation of vitamin D biosynthetic process (GO:0060556)3.03027677
49cellular protein complex localization (GO:0034629)3.02366789
50L-serine metabolic process (GO:0006563)2.99812235
51telomere maintenance via recombination (GO:0000722)2.99430730
52mitochondrial DNA metabolic process (GO:0032042)2.98536918
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98046709
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98046709
55positive regulation of mitotic sister chromatid separation (GO:1901970)2.98046709
56positive regulation of chromosome segregation (GO:0051984)2.95396799
57folic acid metabolic process (GO:0046655)2.93079550
58negative regulation of mRNA metabolic process (GO:1903312)2.92406251
59dosage compensation (GO:0007549)2.87500972
60chromatin assembly or disassembly (GO:0006333)2.86913078
61DNA conformation change (GO:0071103)2.86587680
62regulation of chromatin binding (GO:0035561)2.84239987
63microtubule depolymerization (GO:0007019)2.80635023
64negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.79760880
65ribonucleoprotein complex biogenesis (GO:0022613)2.77775056
66nucleotide salvage (GO:0043173)2.77337939
67response to UV-C (GO:0010225)2.75786747
68ribosome assembly (GO:0042255)2.74920155
69DNA replication-dependent nucleosome organization (GO:0034723)2.74915191
70DNA replication-dependent nucleosome assembly (GO:0006335)2.74915191
71regulation of RNA export from nucleus (GO:0046831)2.73594858
72spliceosomal tri-snRNP complex assembly (GO:0000244)2.72955244
73chromosome segregation (GO:0007059)2.72113475
74termination of RNA polymerase II transcription (GO:0006369)2.72056539
75purine nucleobase biosynthetic process (GO:0009113)2.71330221
76establishment of chromosome localization (GO:0051303)2.71307468
77meiotic chromosome segregation (GO:0045132)2.70557233
78sulfur amino acid catabolic process (GO:0000098)2.70298667
79ATP-dependent chromatin remodeling (GO:0043044)2.69534664
80response to peptidoglycan (GO:0032494)2.63444111
81somatic cell DNA recombination (GO:0016444)2.59422988
82somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.59422988
83rRNA processing (GO:0006364)2.59000252
84serine family amino acid biosynthetic process (GO:0009070)2.58928578
85mitochondrial fusion (GO:0008053)2.58752186
86galactose catabolic process (GO:0019388)2.58087143
87RNA export from nucleus (GO:0006405)2.55795509
88protein localization to chromosome (GO:0034502)2.55684072
89non-recombinational repair (GO:0000726)2.55232539
90double-strand break repair via nonhomologous end joining (GO:0006303)2.55232539
91negative regulation of DNA-templated transcription, elongation (GO:0032785)2.54214036
92nucleotide-excision repair, DNA gap filling (GO:0006297)2.54147991
93rRNA transcription (GO:0009303)2.53647087
94regulation of chromosome segregation (GO:0051983)2.52142974
95viral mRNA export from host cell nucleus (GO:0046784)2.51498850
96mRNA export from nucleus (GO:0006406)2.51180767
97RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.49987871
98regulation of retinoic acid receptor signaling pathway (GO:0048385)2.49164928
99nuclear envelope organization (GO:0006998)2.45781676
100somatic diversification of immune receptors (GO:0002200)2.45294315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.31504905
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.01161312
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.10693144
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.55258649
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35947882
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26092117
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83492480
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68255093
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62349853
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51888521
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42940536
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42149514
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38204059
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35488105
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33986062
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32521434
17MYC_22102868_ChIP-Seq_BL_Human2.31569089
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26982648
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.22078485
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.21688440
21AR_21909140_ChIP-Seq_LNCAP_Human2.19235045
22XRN2_22483619_ChIP-Seq_HELA_Human2.14849571
23DCP1A_22483619_ChIP-Seq_HELA_Human2.13743910
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.08451009
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05176083
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96330442
27VDR_21846776_ChIP-Seq_THP-1_Human1.93539476
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92842346
29* GABP_19822575_ChIP-Seq_HepG2_Human1.90459870
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89959904
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.82044644
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.81210407
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.80954079
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79366241
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78052761
36TTF2_22483619_ChIP-Seq_HELA_Human1.77884945
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76666511
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76038462
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75016529
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70991011
41* VDR_23849224_ChIP-Seq_CD4+_Human1.70505622
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69778692
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.69088413
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67375683
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64784196
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64291169
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63887842
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60084099
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59668027
50* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.56366416
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55414513
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52877396
53CIITA_25753668_ChIP-Seq_RAJI_Human1.51841151
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50523292
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46738754
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46491496
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.44908418
58TFEB_21752829_ChIP-Seq_HELA_Human1.43080650
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42594006
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.40485818
61* ELK1_19687146_ChIP-ChIP_HELA_Human1.39489839
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38611463
63KDM5A_27292631_Chip-Seq_BREAST_Human1.37876813
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36589063
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36236519
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34476639
67* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34460177
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33707419
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30203132
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28454717
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.25758267
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25448087
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23608741
74* SPI1_23547873_ChIP-Seq_NB4_Human1.23238750
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22553170
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21561497
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18093306
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17655688
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16114099
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15942870
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13082467
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12594246
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05645163
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04503358
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.98910648
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98804308
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98642980
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98211594
89ZNF263_19887448_ChIP-Seq_K562_Human0.97310396
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95475160
91BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95199663
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94411571
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94277554
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91517764
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89947967
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86629762
97IRF8_21731497_ChIP-ChIP_J774_Mouse0.86624886
98ATF3_27146783_Chip-Seq_COLON_Human0.85195584
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83882770
100MAF_26560356_Chip-Seq_TH2_Human0.80261994

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.19264864
2MP0010094_abnormal_chromosome_stability3.80195101
3MP0003693_abnormal_embryo_hatching3.67950206
4MP0008057_abnormal_DNA_replication3.39682109
5MP0003111_abnormal_nucleus_morphology3.24336339
6MP0003077_abnormal_cell_cycle3.13920125
7MP0004957_abnormal_blastocyst_morpholog2.92822328
8MP0008058_abnormal_DNA_repair2.63639279
9MP0004185_abnormal_adipocyte_glucose2.52019199
10MP0008932_abnormal_embryonic_tissue2.14774093
11MP0010307_abnormal_tumor_latency2.01909461
12MP0009697_abnormal_copulation1.92742899
13MP0005076_abnormal_cell_differentiation1.90070787
14MP0008007_abnormal_cellular_replicative1.87195952
15MP0002132_abnormal_respiratory_system1.83503773
16MP0009278_abnormal_bone_marrow1.80803851
17MP0002396_abnormal_hematopoietic_system1.75629561
18MP0002009_preneoplasia1.64926966
19MP0000490_abnormal_crypts_of1.64323239
20MP0008260_abnormal_autophagy1.63545152
21MP0004233_abnormal_muscle_weight1.62222166
22MP0006292_abnormal_olfactory_placode1.61185532
23MP0003303_peritoneal_inflammation1.59443220
24MP0001730_embryonic_growth_arrest1.56928784
25MP0003221_abnormal_cardiomyocyte_apopto1.54255999
26MP0000350_abnormal_cell_proliferation1.53018655
27MP0005397_hematopoietic_system_phenotyp1.49646965
28MP0001545_abnormal_hematopoietic_system1.49646965
29MP0003786_premature_aging1.48769390
30MP0003705_abnormal_hypodermis_morpholog1.44479277
31MP0000313_abnormal_cell_death1.36618778
32MP0003436_decreased_susceptibility_to1.36158026
33MP0001764_abnormal_homeostasis1.34232908
34MP0001697_abnormal_embryo_size1.30334763
35MP0001849_ear_inflammation1.26399306
36MP0003890_abnormal_embryonic-extraembry1.25499419
37MP0003724_increased_susceptibility_to1.23911681
38MP0005670_abnormal_white_adipose1.20468602
39MP0003763_abnormal_thymus_physiology1.20384169
40MP0001672_abnormal_embryogenesis/_devel1.20261948
41MP0005380_embryogenesis_phenotype1.20261948
42MP0002006_tumorigenesis1.17616007
43MP0004808_abnormal_hematopoietic_stem1.16391383
44MP0002080_prenatal_lethality1.14036179
45MP0010352_gastrointestinal_tract_polyps1.13281561
46MP0002332_abnormal_exercise_endurance1.12984183
47MP0006035_abnormal_mitochondrial_morpho1.12484991
48MP0005647_abnormal_sex_gland1.12420533
49MP0008789_abnormal_olfactory_epithelium1.11905278
50MP0002398_abnormal_bone_marrow1.10280006
51MP0009785_altered_susceptibility_to1.07851429
52MP0002019_abnormal_tumor_incidence1.07490886
53MP0003984_embryonic_growth_retardation1.07132132
54MP0001800_abnormal_humoral_immune1.07120311
55MP0002722_abnormal_immune_system1.06871300
56MP0000013_abnormal_adipose_tissue1.06860353
57MP0002166_altered_tumor_susceptibility1.06379145
58MP0004197_abnormal_fetal_growth/weight/1.05355569
59MP0004947_skin_inflammation1.05291773
60MP0002088_abnormal_embryonic_growth/wei1.04382947
61MP0002138_abnormal_hepatobiliary_system1.02807255
62MP0009333_abnormal_splenocyte_physiolog0.98800308
63MP0005000_abnormal_immune_tolerance0.96897156
64MP0001835_abnormal_antigen_presentation0.96133701
65MP0002086_abnormal_extraembryonic_tissu0.95284589
66MP0000689_abnormal_spleen_morphology0.94282600
67MP0000358_abnormal_cell_content/0.92870828
68MP0005360_urolithiasis0.92836303
69MP0001216_abnormal_epidermal_layer0.91960204
70MP0002095_abnormal_skin_pigmentation0.90853782
71MP0005266_abnormal_metabolism0.90291657
72MP0001727_abnormal_embryo_implantation0.89708414
73MP0002452_abnormal_antigen_presenting0.89352108
74MP0005666_abnormal_adipose_tissue0.88574422
75MP0003806_abnormal_nucleotide_metabolis0.88557719
76MP0000703_abnormal_thymus_morphology0.88511788
77MP0009764_decreased_sensitivity_to0.88368512
78MP0009053_abnormal_anal_canal0.86962537
79MP0003186_abnormal_redox_activity0.85714492
80MP0005058_abnormal_lysosome_morphology0.85488754
81MP0002429_abnormal_blood_cell0.85024666
82MP0005501_abnormal_skin_physiology0.83259554
83MP0002084_abnormal_developmental_patter0.83167798
84MP0003656_abnormal_erythrocyte_physiolo0.83067328
85MP0000716_abnormal_immune_system0.83066355
86MP0005621_abnormal_cell_physiology0.82926880
87MP0003718_maternal_effect0.81219015
88MP0002085_abnormal_embryonic_tissue0.79705006
89MP0002419_abnormal_innate_immunity0.78567233
90MP0005499_abnormal_olfactory_system0.78239047
91MP0005394_taste/olfaction_phenotype0.78239047
92MP0002723_abnormal_immune_serum0.78101677
93MP0002697_abnormal_eye_size0.77019376
94MP0000003_abnormal_adipose_tissue0.76521431
95MP0010234_abnormal_vibrissa_follicle0.76357714
96MP0002938_white_spotting0.76002597
97MP0002210_abnormal_sex_determination0.75593770
98MP0002420_abnormal_adaptive_immunity0.75165059
99MP0003646_muscle_fatigue0.73849240
100MP0001819_abnormal_immune_cell0.73742650

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)5.08859311
2Hypoplasia of the thymus (HP:0000778)4.40464605
3Panhypogammaglobulinemia (HP:0003139)4.38601043
4Abnormality of B cell number (HP:0010975)4.20357207
5Combined immunodeficiency (HP:0005387)4.15713755
6Severe combined immunodeficiency (HP:0004430)4.13943763
7Microvesicular hepatic steatosis (HP:0001414)4.10939435
8Abnormality of alanine metabolism (HP:0010916)3.92320380
9Hyperalaninemia (HP:0003348)3.92320380
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.92320380
11Cortical dysplasia (HP:0002539)3.73596915
12Progressive external ophthalmoplegia (HP:0000590)3.68863525
13Progressive muscle weakness (HP:0003323)3.54361965
14Abnormal umbilical cord blood vessels (HP:0011403)3.16185342
15Single umbilical artery (HP:0001195)3.16185342
16Abnormality of the fetal cardiovascular system (HP:0010948)3.16185342
17Spontaneous hematomas (HP:0007420)3.12944801
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10108586
19Recurrent viral infections (HP:0004429)3.03970325
20Erythroderma (HP:0001019)2.92512939
21Fatigue (HP:0012378)2.86759909
22Granulocytopenia (HP:0001913)2.85622808
23Thyroiditis (HP:0100646)2.80676357
24Chromsome breakage (HP:0040012)2.71067584
25Birth length less than 3rd percentile (HP:0003561)2.52894774
26Spastic diplegia (HP:0001264)2.52170720
27Ragged-red muscle fibers (HP:0003200)2.51778990
28Esophageal varix (HP:0002040)2.47707288
29T lymphocytopenia (HP:0005403)2.43135409
30Abnormal lung lobation (HP:0002101)2.37731318
31Multiple enchondromatosis (HP:0005701)2.35490808
32Abnormality of the umbilical cord (HP:0010881)2.33231252
33Eosinophilia (HP:0001880)2.26089201
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25179849
35Constricted visual fields (HP:0001133)2.22530048
36Spinal cord lesions (HP:0100561)2.18216387
37Syringomyelia (HP:0003396)2.18216387
38Colitis (HP:0002583)2.17817502
39Bile duct proliferation (HP:0001408)2.17482933
40Abnormal biliary tract physiology (HP:0012439)2.17482933
41Sepsis (HP:0100806)2.11359671
42Bone marrow hypocellularity (HP:0005528)2.10976939
43Shoulder girdle muscle weakness (HP:0003547)2.10944050
44Aplasia/Hypoplasia of the thymus (HP:0010515)2.10843384
45Conjunctival telangiectasia (HP:0000524)2.09919463
46Premature ovarian failure (HP:0008209)2.08392607
47Abnormality of the preputium (HP:0100587)2.06895414
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05279840
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03769074
50External ophthalmoplegia (HP:0000544)2.03452808
51Upper motor neuron abnormality (HP:0002127)2.02957059
52Abnormality of the lower motor neuron (HP:0002366)2.02919739
53Recurrent abscess formation (HP:0002722)2.02087172
54Abnormality of eosinophils (HP:0001879)1.98227181
55Aplasia/Hypoplasia of the uvula (HP:0010293)1.95763581
56Horseshoe kidney (HP:0000085)1.93559683
57Medulloblastoma (HP:0002885)1.93490447
58Proximal placement of thumb (HP:0009623)1.92831785
59Pelvic girdle muscle weakness (HP:0003749)1.92467718
60Nephroblastoma (Wilms tumor) (HP:0002667)1.89834454
6111 pairs of ribs (HP:0000878)1.85128038
62Abnormality of chromosome stability (HP:0003220)1.85029192
63Curly hair (HP:0002212)1.83166709
64Mediastinal lymphadenopathy (HP:0100721)1.80031293
65Cellular immunodeficiency (HP:0005374)1.79801963
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78913460
67Abnormality of serum amino acid levels (HP:0003112)1.78740804
68Recurrent bacterial skin infections (HP:0005406)1.78614857
69Embryonal renal neoplasm (HP:0011794)1.77060356
70Abnormality of the carotid arteries (HP:0005344)1.76571223
71Abnormality of DNA repair (HP:0003254)1.75753335
72Meningitis (HP:0001287)1.75441247
73Recurrent fungal infections (HP:0002841)1.73423973
74Arteriovenous malformation (HP:0100026)1.72689391
75Lymphoma (HP:0002665)1.72145403
76Reticulocytopenia (HP:0001896)1.71054824
77Long palpebral fissure (HP:0000637)1.70870267
78Abnormalities of placenta or umbilical cord (HP:0001194)1.70641873
79Myocardial infarction (HP:0001658)1.70155145
80High anterior hairline (HP:0009890)1.70003307
81Deviation of the thumb (HP:0009603)1.69876442
82Toxemia of pregnancy (HP:0100603)1.69785326
83Selective tooth agenesis (HP:0001592)1.69250395
84Anorexia (HP:0002039)1.69023111
85Abnormality of pyrimidine metabolism (HP:0004353)1.68789263
86Myelodysplasia (HP:0002863)1.68423823
87Abnormality of T cell number (HP:0011839)1.68102440
88Microretrognathia (HP:0000308)1.67936956
89Termporal pattern (HP:0011008)1.67297770
90Insidious onset (HP:0003587)1.67297770
91Squamous cell carcinoma (HP:0002860)1.67161231
92Carpal bone hypoplasia (HP:0001498)1.66890821
93Oral leukoplakia (HP:0002745)1.66201656
94Increased serum lactate (HP:0002151)1.65875809
95Leukocytosis (HP:0001974)1.65376355
96Meckel diverticulum (HP:0002245)1.65286041
97Abnormal foot bone ossification (HP:0010675)1.65217296
98Small intestinal stenosis (HP:0012848)1.64901419
99Duodenal stenosis (HP:0100867)1.64901419
100Overlapping toe (HP:0001845)1.64680788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.76466064
2IRAK33.13140055
3SRPK12.94681380
4SCYL22.72035755
5CCNB12.69128558
6NEK12.44755690
7ZAK2.22602244
8BRSK22.20115052
9PBK2.19468390
10BUB12.10813139
11RPS6KB22.08397374
12MAP2K32.08263687
13PIM22.07575890
14NME21.98911597
15IRAK21.91295642
16CDK121.85934351
17PRPF4B1.79915533
18EIF2AK31.73477935
19LATS11.72582316
20MAP3K31.61461793
21TAOK21.51249602
22ACVR1B1.47431025
23IRAK41.41444129
24DYRK31.41237028
25STK161.38173140
26TAOK11.29283484
27BMPR1B1.26369293
28PIM11.26314904
29CDK191.25244423
30LATS21.24215726
31PLK41.23171480
32BRD41.21192388
33TTK1.19723127
34SMG11.18900622
35AURKA1.18562357
36CHEK21.18461996
37CDK91.17028404
38CDK61.16325853
39MAP3K141.16144737
40ERBB41.13838620
41FGR1.13148513
42TESK21.12711196
43MKNK11.09500954
44PLK11.09294154
45CDK71.08882428
46RPS6KA41.07354375
47JAK31.07242535
48CAMKK21.04691021
49BRSK11.02386123
50AURKB1.02051106
51CLK11.01495987
52ATR0.98867588
53ICK0.98682462
54YES10.96527506
55CHEK10.94828441
56WEE10.93828820
57MAP3K100.93668388
58IRAK10.92709613
59DYRK1B0.90755401
60TYRO30.88416737
61BRAF0.86774406
62RAF10.86691330
63KSR20.79711866
64ARAF0.77183082
65MAP3K80.75543381
66CDK40.73152380
67MAP2K70.71274768
68CDK80.70286957
69ERN10.69780133
70TBK10.63877023
71RPS6KB10.63390452
72RPS6KA10.63022271
73NEK20.62392219
74RPS6KA50.62280960
75MKNK20.61831019
76BCKDK0.60629422
77MOS0.60437620
78EIF2AK10.59508089
79PDK20.56526608
80MAP4K10.56147327
81KSR10.55974141
82CDK20.53715597
83PLK30.49673271
84CAMK1D0.49332279
85MAPK110.48658993
86STK38L0.48221327
87MELK0.47191530
88CDK10.44999169
89IKBKB0.43891154
90AKT20.42324864
91MTOR0.40273029
92ATM0.38493786
93PAK40.37539620
94CSF1R0.37350871
95MAP3K110.37033888
96VRK10.36102534
97TSSK60.35390301
98RPS6KC10.34750434
99RPS6KL10.34750434
100MET0.34662160

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.82528638
2Base excision repair_Homo sapiens_hsa034103.18757526
3Non-homologous end-joining_Homo sapiens_hsa034502.89728913
4Spliceosome_Homo sapiens_hsa030402.83556650
5Mismatch repair_Homo sapiens_hsa034302.79992422
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74720145
7RNA transport_Homo sapiens_hsa030132.41929813
8Cell cycle_Homo sapiens_hsa041102.19997298
9Nucleotide excision repair_Homo sapiens_hsa034202.15023179
10Homologous recombination_Homo sapiens_hsa034402.05278200
11Systemic lupus erythematosus_Homo sapiens_hsa053222.00502616
12Biosynthesis of amino acids_Homo sapiens_hsa012301.89688564
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89061087
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81306293
15Fanconi anemia pathway_Homo sapiens_hsa034601.76103438
16mRNA surveillance pathway_Homo sapiens_hsa030151.73629838
17One carbon pool by folate_Homo sapiens_hsa006701.67144392
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56679575
19Basal transcription factors_Homo sapiens_hsa030221.54341035
20Pyrimidine metabolism_Homo sapiens_hsa002401.50011351
21Sulfur relay system_Homo sapiens_hsa041221.49789409
22Other glycan degradation_Homo sapiens_hsa005111.49714140
23Viral carcinogenesis_Homo sapiens_hsa052031.44627681
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42529781
25Alcoholism_Homo sapiens_hsa050341.37048299
26RNA polymerase_Homo sapiens_hsa030201.35897842
27Primary immunodeficiency_Homo sapiens_hsa053401.34388124
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30304031
29Galactose metabolism_Homo sapiens_hsa000521.27473313
30Bladder cancer_Homo sapiens_hsa052191.22885135
31RNA degradation_Homo sapiens_hsa030181.20376266
32Ribosome_Homo sapiens_hsa030101.19286883
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15561815
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.10836054
35Carbon metabolism_Homo sapiens_hsa012001.09236072
36Acute myeloid leukemia_Homo sapiens_hsa052211.08813661
37Epstein-Barr virus infection_Homo sapiens_hsa051691.08662218
38Herpes simplex infection_Homo sapiens_hsa051681.06788642
39Chronic myeloid leukemia_Homo sapiens_hsa052201.06177688
40B cell receptor signaling pathway_Homo sapiens_hsa046621.01766631
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.00195895
42Selenocompound metabolism_Homo sapiens_hsa004500.99139166
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97321656
44Pentose phosphate pathway_Homo sapiens_hsa000300.96836951
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95123619
46Legionellosis_Homo sapiens_hsa051340.91435387
47p53 signaling pathway_Homo sapiens_hsa041150.90646544
48Non-small cell lung cancer_Homo sapiens_hsa052230.90412710
49Thyroid cancer_Homo sapiens_hsa052160.88294079
50Pancreatic cancer_Homo sapiens_hsa052120.85655071
51Influenza A_Homo sapiens_hsa051640.84137075
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83778394
53Arginine biosynthesis_Homo sapiens_hsa002200.81699776
54Renal cell carcinoma_Homo sapiens_hsa052110.80557642
55Hepatitis B_Homo sapiens_hsa051610.79962848
56Osteoclast differentiation_Homo sapiens_hsa043800.79016920
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75991470
58MicroRNAs in cancer_Homo sapiens_hsa052060.74918010
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74658968
60Folate biosynthesis_Homo sapiens_hsa007900.74643243
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73965674
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73541581
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72185954
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70272960
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68882333
66HTLV-I infection_Homo sapiens_hsa051660.68270827
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.67685013
68Colorectal cancer_Homo sapiens_hsa052100.67313944
69Endometrial cancer_Homo sapiens_hsa052130.66130276
70Apoptosis_Homo sapiens_hsa042100.66086025
71Leishmaniasis_Homo sapiens_hsa051400.61126538
72Fatty acid biosynthesis_Homo sapiens_hsa000610.57784455
73FoxO signaling pathway_Homo sapiens_hsa040680.56975154
74Sulfur metabolism_Homo sapiens_hsa009200.55339281
75Purine metabolism_Homo sapiens_hsa002300.54744493
76Shigellosis_Homo sapiens_hsa051310.54653994
77Tuberculosis_Homo sapiens_hsa051520.53872619
78Inositol phosphate metabolism_Homo sapiens_hsa005620.51196434
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51019552
80Measles_Homo sapiens_hsa051620.49511359
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49036932
82Steroid biosynthesis_Homo sapiens_hsa001000.49015636
83TNF signaling pathway_Homo sapiens_hsa046680.46880197
84mTOR signaling pathway_Homo sapiens_hsa041500.45375639
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44650003
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42775734
87ErbB signaling pathway_Homo sapiens_hsa040120.42076300
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41929438
89Small cell lung cancer_Homo sapiens_hsa052220.41588589
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41354261
91Hepatitis C_Homo sapiens_hsa051600.40872779
92Fructose and mannose metabolism_Homo sapiens_hsa000510.40687000
93Prolactin signaling pathway_Homo sapiens_hsa049170.39476074
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.38330213
95Lysosome_Homo sapiens_hsa041420.38257199
96Proteasome_Homo sapiens_hsa030500.36617213
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36576725
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35443064
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.35136884
100Prostate cancer_Homo sapiens_hsa052150.34606114

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