SPATA45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.94757145
2cilium or flagellum-dependent cell motility (GO:0001539)9.72099841
3axonemal dynein complex assembly (GO:0070286)9.62468595
4epithelial cilium movement (GO:0003351)9.56825879
5motile cilium assembly (GO:0044458)9.41353211
6spermatid development (GO:0007286)9.09301881
7sphingoid metabolic process (GO:0046519)9.01736363
8cilium movement (GO:0003341)7.69933517
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.68887580
10single fertilization (GO:0007338)7.58522348
11regulation of cilium movement (GO:0003352)7.38347515
12male meiosis (GO:0007140)7.08270866
13piRNA metabolic process (GO:0034587)7.02701327
14regulation of protein glycosylation (GO:0060049)7.00021098
15synaptonemal complex assembly (GO:0007130)6.98210240
16synaptonemal complex organization (GO:0070193)6.96500326
17microtubule depolymerization (GO:0007019)6.58705227
18sperm capacitation (GO:0048240)6.40876666
19fertilization (GO:0009566)6.29992080
20L-phenylalanine catabolic process (GO:0006559)6.23488240
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.23488240
22regulation of meiosis I (GO:0060631)6.22150486
23spermatogenesis (GO:0007283)6.19836886
24male gamete generation (GO:0048232)6.17768210
25protein-chromophore linkage (GO:0018298)6.12818217
26negative regulation of inclusion body assembly (GO:0090084)5.75862881
27regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.71289115
28lipopolysaccharide biosynthetic process (GO:0009103)5.69968209
29gamete generation (GO:0007276)5.67908022
30negative regulation of glycoprotein biosynthetic process (GO:0010561)5.65740831
31DNA deamination (GO:0045006)5.62993860
32organic cation transport (GO:0015695)5.59833770
33calcium ion-dependent exocytosis (GO:0017156)5.34224012
34L-phenylalanine metabolic process (GO:0006558)5.28002086
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.28002086
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.21307690
37cell recognition (GO:0008037)5.13002478
38germ cell development (GO:0007281)5.07400993
39organelle disassembly (GO:1903008)5.03522442
40sulfate transmembrane transport (GO:1902358)4.98852279
41regulation of inclusion body assembly (GO:0090083)4.94463135
42lipopolysaccharide metabolic process (GO:0008653)4.92582992
43glycerol ether metabolic process (GO:0006662)4.86999323
44chromosome organization involved in meiosis (GO:0070192)4.81977201
45ventricular system development (GO:0021591)4.71303727
46spermatid nucleus differentiation (GO:0007289)4.63863352
47DNA methylation involved in gamete generation (GO:0043046)4.61962731
48positive regulation of developmental pigmentation (GO:0048087)4.60093566
49ether metabolic process (GO:0018904)4.49478184
50male meiosis I (GO:0007141)4.46468553
51multicellular organismal reproductive process (GO:0048609)4.45272023
52tyrosine metabolic process (GO:0006570)4.43502322
53ribonucleoprotein complex disassembly (GO:0032988)4.42301006
54negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.40586098
55seminiferous tubule development (GO:0072520)4.38864671
56negative regulation of glycoprotein metabolic process (GO:1903019)4.37875603
57regulation of microtubule-based movement (GO:0060632)4.30223484
58chaperone-mediated protein complex assembly (GO:0051131)4.28767708
59monoubiquitinated protein deubiquitination (GO:0035520)4.23020370
60microtubule severing (GO:0051013)4.19742074
61chromosome condensation (GO:0030261)4.19105157
62meiotic nuclear division (GO:0007126)4.16378649
63sulfate transport (GO:0008272)4.14651532
64regulation of pigment cell differentiation (GO:0050932)4.05298568
65positive regulation of glycolytic process (GO:0045821)4.01796402
66sequestering of actin monomers (GO:0042989)3.96809271
67DNA packaging (GO:0006323)3.95076847
68aromatic amino acid family catabolic process (GO:0009074)3.86857600
69negative regulation of cell cycle G2/M phase transition (GO:1902750)3.84198567
70paraxial mesoderm development (GO:0048339)3.81247392
71protein K11-linked deubiquitination (GO:0035871)3.80174046
72regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.77692454
73regulation of transforming growth factor beta2 production (GO:0032909)3.76959043
74polyol catabolic process (GO:0046174)3.75606231
75regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.73900944
76left/right pattern formation (GO:0060972)3.72927727
77chemosensory behavior (GO:0007635)3.72181271
78GTP biosynthetic process (GO:0006183)3.66179966
79nodal signaling pathway (GO:0038092)3.63859468
80meiosis I (GO:0007127)3.63141221
81multicellular organismal development (GO:0007275)3.60784878
82single strand break repair (GO:0000012)3.59405903
83nucleoside diphosphate phosphorylation (GO:0006165)3.57406962
84negative regulation of telomere maintenance (GO:0032205)3.56812146
85heme transport (GO:0015886)3.52759302
86genitalia morphogenesis (GO:0035112)3.48228312
87SMAD protein complex assembly (GO:0007183)3.46262893
88microtubule polymerization or depolymerization (GO:0031109)3.45543155
89cellular response to gamma radiation (GO:0071480)3.40880864
90lactate metabolic process (GO:0006089)3.34427352
91UTP biosynthetic process (GO:0006228)3.30675581
92serotonin receptor signaling pathway (GO:0007210)3.29022396
93alditol metabolic process (GO:0019400)3.23791429
94purine deoxyribonucleotide catabolic process (GO:0009155)3.22260842
95protein localization to cilium (GO:0061512)3.21193072
96protein polyglutamylation (GO:0018095)3.19693713
97meiotic cell cycle (GO:0051321)3.18213675
98glycolytic process (GO:0006096)3.14937797
99folic acid-containing compound biosynthetic process (GO:0009396)3.13671314
100telomere maintenance via semi-conservative replication (GO:0032201)3.11771252
101sexual reproduction (GO:0019953)3.11718320
102mitochondrial fission (GO:0000266)3.10913371
103positive regulation of meiosis (GO:0045836)3.09996239
104regulation of type B pancreatic cell apoptotic process (GO:2000674)3.08658293
105regulation of spindle checkpoint (GO:0090231)3.07598217
106notochord development (GO:0030903)3.05762563
107aspartate family amino acid catabolic process (GO:0009068)3.05219499
108intraciliary transport (GO:0042073)3.02732420
109negative regulation of thymocyte apoptotic process (GO:0070244)3.02340295
110UTP metabolic process (GO:0046051)2.97919888
111urate metabolic process (GO:0046415)2.97080209
112cilium morphogenesis (GO:0060271)2.96874264
113aromatic amino acid family metabolic process (GO:0009072)2.93707383
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93240070
115centriole assembly (GO:0098534)2.92479385
116synapsis (GO:0007129)2.89129441
117centriole replication (GO:0007099)2.88949655
118glycerol metabolic process (GO:0006071)2.86481710
119axoneme assembly (GO:0035082)2.86280138
120cytidine deamination (GO:0009972)2.85341373
121cytidine metabolic process (GO:0046087)2.85341373
122cytidine catabolic process (GO:0006216)2.85341373
123positive regulation of meiotic cell cycle (GO:0051446)2.84373108
124ER overload response (GO:0006983)2.84100572
125negative regulation of receptor activity (GO:2000272)2.83522452
126cellular component assembly involved in morphogenesis (GO:0010927)2.83056275
127deoxyribonucleotide catabolic process (GO:0009264)2.82688185
128cilium organization (GO:0044782)2.82361907
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.82342334
130microtubule-based movement (GO:0007018)2.80202223
131mitotic sister chromatid cohesion (GO:0007064)2.79065619
132protein refolding (GO:0042026)2.78883700
133amino-acid betaine transport (GO:0015838)2.78667844
134carnitine transport (GO:0015879)2.78667844
135toxin metabolic process (GO:0009404)2.77642087
136protein-cofactor linkage (GO:0018065)2.76114486
137endocrine pancreas development (GO:0031018)2.75834302
138gamma-aminobutyric acid signaling pathway (GO:0007214)2.75284065
139DNA strand elongation involved in DNA replication (GO:0006271)2.74714456
140mitotic recombination (GO:0006312)2.73971706
141guanosine-containing compound biosynthetic process (GO:1901070)2.73842661
142cilium assembly (GO:0042384)2.73699071
143magnesium ion transport (GO:0015693)2.71587573
144meiotic cell cycle process (GO:1903046)2.70894937
145nucleus organization (GO:0006997)2.70276938
146vitamin transmembrane transport (GO:0035461)2.68772625
147activin receptor signaling pathway (GO:0032924)2.66623834
148uterus development (GO:0060065)2.65897545
149tetrahydrofolate metabolic process (GO:0046653)2.65764273
150carnitine transmembrane transport (GO:1902603)2.65155364
151iron coordination entity transport (GO:1901678)2.64288953
152positive regulation of macrophage activation (GO:0043032)2.63755048
153sulfur compound transport (GO:0072348)2.63688317
154valine metabolic process (GO:0006573)2.61593294
155cell redox homeostasis (GO:0045454)2.61343327
156flavonoid metabolic process (GO:0009812)2.60350200
157ubiquinone biosynthetic process (GO:0006744)2.60071102
158single-organism membrane fusion (GO:0044801)2.59458549
159gene silencing by RNA (GO:0031047)2.59316931
160positive regulation of SMAD protein import into nucleus (GO:0060391)2.59293488
161regulation of centriole replication (GO:0046599)2.56657096
162purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.56538566
163mannosylation (GO:0097502)2.55676691
164ubiquinone metabolic process (GO:0006743)2.55640417
165deoxyribose phosphate catabolic process (GO:0046386)2.55512548
166pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54871469
167pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.54394614
168CTP metabolic process (GO:0046036)2.54223567
169telomere maintenance via recombination (GO:0000722)2.51820268
170regulation of glycolytic process (GO:0006110)2.51788447
171DNA strand elongation (GO:0022616)2.50680625
172regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50228046
173negative regulation of membrane potential (GO:0045837)2.50053778
174protein maturation by protein folding (GO:0022417)2.49312403
175response to epinephrine (GO:0071871)2.48451871
176negative regulation of oxidoreductase activity (GO:0051354)2.47773768
177reciprocal meiotic recombination (GO:0007131)2.47233670
178reciprocal DNA recombination (GO:0035825)2.47233670
179telomere maintenance via telomere lengthening (GO:0010833)2.46495687
180somatic hypermutation of immunoglobulin genes (GO:0016446)2.46225719
181somatic diversification of immune receptors via somatic mutation (GO:0002566)2.46225719
182somite rostral/caudal axis specification (GO:0032525)2.45518818
183negative regulation of DNA replication (GO:0008156)2.42800179
184fusion of sperm to egg plasma membrane (GO:0007342)15.3856951
185cell wall macromolecule catabolic process (GO:0016998)14.7487943
186cell wall macromolecule metabolic process (GO:0044036)14.7487943
187acrosome assembly (GO:0001675)13.4170765
188sperm motility (GO:0030317)12.4757274
189multicellular organism reproduction (GO:0032504)11.8991109
190sperm-egg recognition (GO:0035036)11.8398764
191plasma membrane fusion (GO:0045026)11.7317949
192sphingosine metabolic process (GO:0006670)11.3620056
193acrosome reaction (GO:0007340)10.8717000
194binding of sperm to zona pellucida (GO:0007339)10.6622934
195cell-cell recognition (GO:0009988)10.5953397
196diol metabolic process (GO:0034311)10.1966850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human6.29546664
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.61883932
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.79518590
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.48668841
5E2F7_22180533_ChIP-Seq_HELA_Human3.34833847
6EZH2_22144423_ChIP-Seq_EOC_Human3.27708601
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01283323
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.97792726
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.74077335
10AR_21572438_ChIP-Seq_LNCaP_Human2.68712144
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.57757776
12FUS_26573619_Chip-Seq_HEK293_Human2.49957320
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.36549316
14ZNF274_21170338_ChIP-Seq_K562_Hela2.31316436
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25062322
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24984778
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.14203118
18P300_19829295_ChIP-Seq_ESCs_Human2.09802217
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09720308
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08042578
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.05965208
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03030785
23ER_23166858_ChIP-Seq_MCF-7_Human2.00791145
24NANOG_19829295_ChIP-Seq_ESCs_Human2.00761380
25SOX2_19829295_ChIP-Seq_ESCs_Human2.00761380
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2997202
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92689662
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86876186
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.86463124
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83612838
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.83454162
32VDR_22108803_ChIP-Seq_LS180_Human1.83327047
33RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.83011649
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82236996
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79546805
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.78600001
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75311154
38HOXB7_26014856_ChIP-Seq_BT474_Human1.73437201
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.71947988
40STAT1_17558387_ChIP-Seq_HELA_Human1.70788214
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69366377
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.68670157
43KDM2B_26808549_Chip-Seq_REH_Human1.60677679
44TAL1_26923725_Chip-Seq_HPCs_Mouse1.60645832
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59154732
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.59151118
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.58849979
48GBX2_23144817_ChIP-Seq_PC3_Human1.57541383
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56009802
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55560065
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55030542
52STAT1_20625510_ChIP-Seq_HELA_Human1.54750974
53SOX2_22085726_ChIP-Seq_NPCs_Mouse1.53745799
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.52525674
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.51530858
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51530858
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50502289
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48647321
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48487702
60FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48424791
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.47491876
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47208367
63AR_25329375_ChIP-Seq_VCAP_Human1.46459586
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.44931104
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42752166
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40692324
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.38936323
68LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38087030
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.35683073
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34260158
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31947654
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.31853942
73TCF4_23295773_ChIP-Seq_U87_Human1.31679542
74STAT3_23295773_ChIP-Seq_U87_Human1.30666198
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30297674
76AR_20517297_ChIP-Seq_VCAP_Human1.29160812
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28828355
78P53_21459846_ChIP-Seq_SAOS-2_Human1.28674614
79GATA3_21867929_ChIP-Seq_TH1_Mouse1.28449647
80ELK1_19687146_ChIP-ChIP_HELA_Human1.27209782
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26966354
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26851946
83REST_21632747_ChIP-Seq_MESCs_Mouse1.26847324
84NCOR_22424771_ChIP-Seq_293T_Human1.26645045
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26447999
86OCT4_20526341_ChIP-Seq_ESCs_Human1.25600196
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.25508956
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24606923
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.23648987
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23100051
91CBP_20019798_ChIP-Seq_JUKART_Human1.23100051
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22673503
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22568335
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22304661
95NANOG_20526341_ChIP-Seq_ESCs_Human1.22059451
96MYC_19829295_ChIP-Seq_ESCs_Human1.20934670
97GF1_26923725_Chip-Seq_HPCs_Mouse1.20829573
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20100151
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19827086
100TP53_22573176_ChIP-Seq_HFKS_Human1.18255777
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18147121
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.17797311
103OCT4_18555785_Chip-Seq_ESCs_Mouse1.17385497
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17345862
105CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16694187
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16614692
107CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15780474
108FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15679661
109EWS_26573619_Chip-Seq_HEK293_Human1.14665383
110P53_22387025_ChIP-Seq_ESCs_Mouse1.13763547
111SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13280765
112RNF2_27304074_Chip-Seq_NSC_Mouse1.11914233
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.11706814
114FOXP3_21729870_ChIP-Seq_TREG_Human1.11430977
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.11261043
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10279601
117CDX2_22108803_ChIP-Seq_LS180_Human1.09929221
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.09628572
119TAF15_26573619_Chip-Seq_HEK293_Human1.09610816
120P300_18555785_Chip-Seq_ESCs_Mouse1.09475647
121BCAT_22108803_ChIP-Seq_LS180_Human1.09432869
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07166198
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07009995
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06916416
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06430601
126RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05808754
127GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04897229
128RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04785274
129RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04103584
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03682140
131ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03517741
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02854065
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02710202
134KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02014585
135SPI1_26923725_Chip-Seq_HPCs_Mouse1.01989785
136CEBPB_22108803_ChIP-Seq_LS180_Human1.01155775
137SOX9_26525672_Chip-Seq_HEART_Mouse1.00126478
138SMAD4_21799915_ChIP-Seq_A2780_Human0.99984734
139SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99880930
140LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99841803
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.99362744
142ERG_20517297_ChIP-Seq_VCAP_Human0.99161568
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.99051669
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98586255
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98440048
146SMAD4_21741376_ChIP-Seq_EPCs_Human0.98257901
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98252058
148RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97925866
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.96690228
150FOXH1_21741376_ChIP-Seq_EPCs_Human0.96638387
151EST1_17652178_ChIP-ChIP_JURKAT_Human0.96293512
152SOX2_18555785_Chip-Seq_ESCs_Mouse0.96071519
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95790408
154CBP_21632823_ChIP-Seq_H3396_Human0.95628236
155RXR_22108803_ChIP-Seq_LS180_Human0.95244511
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94398908
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94398908
158STAT3_18555785_Chip-Seq_ESCs_Mouse0.94225164
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93965793
160PU1_27457419_Chip-Seq_LIVER_Mouse0.92485921
161RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92141682
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.92003649
163TAF2_19829295_ChIP-Seq_ESCs_Human0.91912799
164FLI1_21867929_ChIP-Seq_CD8_Mouse0.89811013
165FOXH1_21741376_ChIP-Seq_ESCs_Human0.89808527
166E2F1_18555785_Chip-Seq_ESCs_Mouse0.89241256
167CTCF_18555785_Chip-Seq_ESCs_Mouse0.88854244
168KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88558328
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88108259
170NMYC_18555785_Chip-Seq_ESCs_Mouse0.87721929
171STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.87681381
172RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87655997
173PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86996168
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86674945
175PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85690578
176TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85576983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis9.11232439
2MP0003136_yellow_coat_color6.32543863
3MP0003698_abnormal_male_reproductive6.01264113
4MP0005171_absent_coat_pigmentation5.81426836
5MP0001929_abnormal_gametogenesis5.59772386
6MP0008877_abnormal_DNA_methylation4.57196067
7MP0002210_abnormal_sex_determination3.51439212
8MP0003195_calcinosis3.31755607
9MP0002161_abnormal_fertility/fecundity3.26664413
10MP0003045_fibrosis3.04801026
11MP0001145_abnormal_male_reproductive3.00088090
12MP0003879_abnormal_hair_cell2.87478097
13MP0005670_abnormal_white_adipose2.66289085
14MP0000653_abnormal_sex_gland2.62726490
15MP0002138_abnormal_hepatobiliary_system2.57856636
16MP0005085_abnormal_gallbladder_physiolo2.47576776
17MP0010352_gastrointestinal_tract_polyps2.21565491
18MP0002653_abnormal_ependyma_morphology2.15367378
19MP0002160_abnormal_reproductive_system2.08569925
20MP0005410_abnormal_fertilization15.9279632
21MP0004381_abnormal_hair_follicle1.93112552
22MP0004233_abnormal_muscle_weight1.86929027
23MP0003252_abnormal_bile_duct1.84983347
24MP0003283_abnormal_digestive_organ1.83114574
25MP0002254_reproductive_system_inflammat1.74876372
26MP0002132_abnormal_respiratory_system1.73692496
27MP0005075_abnormal_melanosome_morpholog1.70896903
28MP0006054_spinal_hemorrhage1.60359488
29MP0000569_abnormal_digit_pigmentation1.51708195
30MP0001984_abnormal_olfaction1.50326868
31MP0002234_abnormal_pharynx_morphology1.48685676
32MP0005646_abnormal_pituitary_gland1.47906466
33MP0000749_muscle_degeneration1.47615371
34MP0002938_white_spotting1.47088252
35MP0008057_abnormal_DNA_replication1.44487357
36MP0002168_other_aberrant_phenotype1.43416364
37MP0001529_abnormal_vocalization1.41569449
38MP0002277_abnormal_respiratory_mucosa1.33495871
39MP0008058_abnormal_DNA_repair1.32799433
40MP0005623_abnormal_meninges_morphology1.31259636
41MP0001501_abnormal_sleep_pattern1.21024951
42MP0002090_abnormal_vision1.18014643
43MP0008872_abnormal_physiological_respon1.17109640
44MP0005395_other_phenotype1.12702231
45MP0005389_reproductive_system_phenotype1.09025543
46MP0008875_abnormal_xenobiotic_pharmacok1.07700899
47MP0005647_abnormal_sex_gland1.04591407
48MP0003646_muscle_fatigue1.03624853
49MP0003137_abnormal_impulse_conducting1.03561622
50MP0005084_abnormal_gallbladder_morpholo1.01321566
51MP0001765_abnormal_ion_homeostasis1.00921881
52MP0001756_abnormal_urination0.99263051
53MP0000427_abnormal_hair_cycle0.97508858
54MP0005220_abnormal_exocrine_pancreas0.94900984
55MP0003806_abnormal_nucleotide_metabolis0.94674790
56MP0002272_abnormal_nervous_system0.92762250
57MP0002876_abnormal_thyroid_physiology0.91604686
58MP0009046_muscle_twitch0.90053267
59MP0003075_altered_response_to0.88730048
60MP0004147_increased_porphyrin_level0.88487569
61MP0005551_abnormal_eye_electrophysiolog0.87956139
62MP0002075_abnormal_coat/hair_pigmentati0.86854124
63MP0003011_delayed_dark_adaptation0.86076512
64MP0002282_abnormal_trachea_morphology0.85675668
65MP0010094_abnormal_chromosome_stability0.85605820
66MP0001986_abnormal_taste_sensitivity0.84790149
67MP0002163_abnormal_gland_morphology0.83795502
68MP0003300_gastrointestinal_ulcer0.82238246
69MP0009764_decreased_sensitivity_to0.81821597
70MP0002095_abnormal_skin_pigmentation0.81607703
71MP0004142_abnormal_muscle_tone0.76950394
72MP0003959_abnormal_lean_body0.76018929
73MP0008995_early_reproductive_senescence0.75647010
74MP0003786_premature_aging0.73807724
75MP0003705_abnormal_hypodermis_morpholog0.73025695
76MP0010386_abnormal_urinary_bladder0.72676881
77MP0009745_abnormal_behavioral_response0.70465733
78MP0001944_abnormal_pancreas_morphology0.70336411
79MP0002332_abnormal_exercise_endurance0.69508567
80MP0008007_abnormal_cellular_replicative0.69311886
81MP0010329_abnormal_lipoprotein_level0.68865918
82MP0002735_abnormal_chemical_nociception0.67971942
83MP0005636_abnormal_mineral_homeostasis0.64025199
84MP0003718_maternal_effect0.62913885
85MP0002102_abnormal_ear_morphology0.60828103
86MP0004133_heterotaxia0.60718486
87MP0005266_abnormal_metabolism0.60287746
88MP0003183_abnormal_peptide_metabolism0.60134339
89MP0009697_abnormal_copulation0.59584515
90MP0005253_abnormal_eye_physiology0.59174556
91MP0002269_muscular_atrophy0.59086131
92MP0005165_increased_susceptibility_to0.58744819
93MP0000678_abnormal_parathyroid_gland0.58113178
94MP0005330_cardiomyopathy0.58088838
95MP0005332_abnormal_amino_acid0.57196345
96MP0001324_abnormal_eye_pigmentation0.56490512
97MP0005076_abnormal_cell_differentiation0.56060995
98MP0000358_abnormal_cell_content/0.55935529
99MP0004036_abnormal_muscle_relaxation0.55637774
100MP0001764_abnormal_homeostasis0.55628570
101MP0003111_abnormal_nucleus_morphology0.54799368
102MP0001186_pigmentation_phenotype0.54191182
103MP0006036_abnormal_mitochondrial_physio0.53843705
104MP0003950_abnormal_plasma_membrane0.51821676
105MP0006072_abnormal_retinal_apoptosis0.51346717
106MP0003699_abnormal_female_reproductive0.50995477
107MP0005666_abnormal_adipose_tissue0.50851760
108MP0002118_abnormal_lipid_homeostasis0.50637170
109MP0001545_abnormal_hematopoietic_system0.47066191
110MP0005397_hematopoietic_system_phenotyp0.47066191
111MP0010307_abnormal_tumor_latency0.46831609
112MP0009643_abnormal_urine_homeostasis0.46486970
113MP0008569_lethality_at_weaning0.43861116
114MP0002136_abnormal_kidney_physiology0.41262453
115MP0001119_abnormal_female_reproductive0.41108676
116MP0003953_abnormal_hormone_level0.40296959
117MP0010234_abnormal_vibrissa_follicle0.38690421
118MP0002928_abnormal_bile_duct0.38658276
119MP0003077_abnormal_cell_cycle0.37966443
120MP0005391_vision/eye_phenotype0.37472562
121MP0001730_embryonic_growth_arrest0.37291437
122MP0004019_abnormal_vitamin_homeostasis0.37002277
123MP0001293_anophthalmia0.35538038
124MP0002736_abnormal_nociception_after0.34375646
125MP0003115_abnormal_respiratory_system0.33488280
126MP0004811_abnormal_neuron_physiology0.30642412
127MP0002909_abnormal_adrenal_gland0.29521241
128MP0000313_abnormal_cell_death0.29225783
129MP0004264_abnormal_extraembryonic_tissu0.28538192
130MP0004808_abnormal_hematopoietic_stem0.28520579
131MP0004084_abnormal_cardiac_muscle0.27610011
132MP0002139_abnormal_hepatobiliary_system0.25185208
133MP0005319_abnormal_enzyme/_coenzyme0.24684840
134MP0003633_abnormal_nervous_system0.23637264
135MP0003329_amyloid_beta_deposits0.23318533
136MP0001727_abnormal_embryo_implantation0.23095949
137MP0006035_abnormal_mitochondrial_morpho0.22970375
138MP0005365_abnormal_bile_salt0.22112625
139MP0008932_abnormal_embryonic_tissue0.21900610
140MP0004043_abnormal_pH_regulation0.21181369
141MP0005195_abnormal_posterior_eye0.21113404
142MP0002152_abnormal_brain_morphology0.20224212
143MP0000534_abnormal_ureter_morphology0.20031869
144MP0001697_abnormal_embryo_size0.19881622
145MP0002084_abnormal_developmental_patter0.19196103
146MP0009115_abnormal_fat_cell0.18961475
147MP0002169_no_abnormal_phenotype0.18778062
148MP0003861_abnormal_nervous_system0.18648751
149MP0002873_normal_phenotype0.18522440
150MP0004957_abnormal_blastocyst_morpholog0.17727615
151MP0003878_abnormal_ear_physiology0.17677196
152MP0005377_hearing/vestibular/ear_phenot0.17677196
153MP0001661_extended_life_span0.17532108
154MP0001672_abnormal_embryogenesis/_devel0.17436831
155MP0005380_embryogenesis_phenotype0.17436831
156MP0002693_abnormal_pancreas_physiology0.17170964
157MP0001968_abnormal_touch/_nociception0.16965327
158MP0001502_abnormal_circadian_rhythm0.16960416
159MP0002229_neurodegeneration0.16825552
160MP0002080_prenatal_lethality0.16671673
161MP0002971_abnormal_brown_adipose0.14608980
162MP0003890_abnormal_embryonic-extraembry0.14573068
163MP0003984_embryonic_growth_retardation0.14514341
164MP0003631_nervous_system_phenotype0.14250869
165MP0005535_abnormal_body_temperature0.14008363
166MP0000001_mammalian_phenotype0.13971539
167MP0004270_analgesia0.13296798

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.75879188
2Abnormal respiratory motile cilium morphology (HP:0005938)9.56708788
3Abnormal respiratory epithelium morphology (HP:0012253)9.56708788
4Abnormal ciliary motility (HP:0012262)8.05059737
5Chronic bronchitis (HP:0004469)7.88580981
6Rhinitis (HP:0012384)7.74648007
7Amelogenesis imperfecta (HP:0000705)7.06759053
8Focal motor seizures (HP:0011153)6.87192231
9Infertility (HP:0000789)6.38084210
10Aplastic anemia (HP:0001915)6.33714272
11Nasal polyposis (HP:0100582)6.15049159
12Spontaneous hematomas (HP:0007420)5.17359770
13Parakeratosis (HP:0001036)5.05687643
14Abnormality of the nasal mucosa (HP:0000433)5.03659759
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.91900140
16Acanthocytosis (HP:0001927)4.85689566
17Bronchitis (HP:0012387)4.37822198
18Conjunctival telangiectasia (HP:0000524)4.33679002
19Bronchiectasis (HP:0002110)4.30820568
20Abnormality of aromatic amino acid family metabolism (HP:0004338)4.27149957
21Recurrent sinusitis (HP:0011108)3.79583897
22Rectal prolapse (HP:0002035)3.69246000
23Nephronophthisis (HP:0000090)3.68560411
24Male infertility (HP:0003251)3.67976999
25Dialeptic seizures (HP:0011146)3.61731558
26Hyperinsulinemic hypoglycemia (HP:0000825)3.56966964
27Abnormality of the vasculature of the conjunctiva (HP:0008054)3.50888363
28Proximal amyotrophy (HP:0007126)3.36377986
29Medial flaring of the eyebrow (HP:0010747)3.17672743
30Recurrent otitis media (HP:0000403)3.13257858
31Aplasia/Hypoplasia of the uvula (HP:0010293)3.11943999
32Autoimmune hemolytic anemia (HP:0001890)3.06566530
33Colon cancer (HP:0003003)3.02138785
34Abnormal spermatogenesis (HP:0008669)3.01491185
35Hematochezia (HP:0002573)2.99639432
36Esophageal varix (HP:0002040)2.99592753
37Abnormality of the renal medulla (HP:0100957)2.76950992
38Abnormality of the pancreatic islet cells (HP:0006476)2.64232114
39Abnormality of endocrine pancreas physiology (HP:0012093)2.64232114
40Retinal atrophy (HP:0001105)2.63540034
41Molar tooth sign on MRI (HP:0002419)2.60445595
42Abnormality of midbrain morphology (HP:0002418)2.60445595
43Congenital ichthyosiform erythroderma (HP:0007431)2.57013227
44Portal hypertension (HP:0001409)2.54728481
45Symptomatic seizures (HP:0011145)2.54720980
46Tubulointerstitial nephritis (HP:0001970)2.51726521
47Visceral angiomatosis (HP:0100761)2.49775978
48IgM deficiency (HP:0002850)2.47051005
49Ulnar claw (HP:0001178)2.43713527
50Acute hepatic failure (HP:0006554)2.39880411
51Central scotoma (HP:0000603)2.38084916
52Erythroderma (HP:0001019)2.36473944
53Palpitations (HP:0001962)2.35182089
54Congenital primary aphakia (HP:0007707)2.32530179
55Hemangiomatosis (HP:0007461)2.32111563
56Gait imbalance (HP:0002141)2.31536656
57Abnormality of the hepatic vasculature (HP:0006707)2.29588533
58Cavernous hemangioma (HP:0001048)2.28907361
59Difficulty walking (HP:0002355)2.27280567
60Abnormal albumin level (HP:0012116)2.25927115
61Hypoalbuminemia (HP:0003073)2.25927115
62Focal seizures (HP:0007359)2.24249607
63Testicular atrophy (HP:0000029)2.24178553
64Abnormality of the vocal cords (HP:0008777)2.23629275
65Enlarged kidneys (HP:0000105)2.21865639
66Impulsivity (HP:0100710)2.21730659
67Disproportionate short-trunk short stature (HP:0003521)2.20562821
68Petechiae (HP:0000967)2.19463606
69Gonadotropin excess (HP:0000837)2.17947308
70Ketoacidosis (HP:0001993)2.16040124
71Type I transferrin isoform profile (HP:0003642)2.14983376
72Prominent metopic ridge (HP:0005487)2.12730797
73Hypomagnesemia (HP:0002917)2.12522620
74Pancytopenia (HP:0001876)2.10192675
75Progressive inability to walk (HP:0002505)2.09339018
76Mucosal telangiectasiae (HP:0100579)2.09316865
77Facial shape deformation (HP:0011334)2.07832296
78Potter facies (HP:0002009)2.07832296
79Azoospermia (HP:0000027)2.07270511
80Overlapping toe (HP:0001845)2.04988897
81Flat capital femoral epiphysis (HP:0003370)2.04361696
82Recurrent bronchitis (HP:0002837)2.03983009
83Muscle hypertrophy of the lower extremities (HP:0008968)2.02571030
84Chronic diarrhea (HP:0002028)2.01297930
85Dynein arm defect of respiratory motile cilia (HP:0012255)13.9282371
86Absent/shortened dynein arms (HP:0200106)13.9282371
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4143486
88Nephrogenic diabetes insipidus (HP:0009806)1.99845182
89Hyperglycemia (HP:0003074)1.98912528
90Tubular atrophy (HP:0000092)1.97822025
91Hypoglycemic coma (HP:0001325)1.96834737
92Tubulointerstitial abnormality (HP:0001969)1.96576914
93Increased IgM level (HP:0003496)1.96304381
94Hypokalemia (HP:0002900)1.94862923
95Abnormality of the costochondral junction (HP:0000919)1.94838306
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.93709757
97Pancreatic islet-cell hyperplasia (HP:0004510)1.88125777
98Poikilocytosis (HP:0004447)1.87860210
99Horizontal nystagmus (HP:0000666)1.87406231
100Acute encephalopathy (HP:0006846)1.87198069
101Insulin-resistant diabetes mellitus (HP:0000831)1.86088639
102Hypoplasia of the pons (HP:0012110)1.85451211
103Hypoplasia of the odontoid process (HP:0003311)1.85158429
104Rectovaginal fistula (HP:0000143)1.83457167
105Rectal fistula (HP:0100590)1.83457167
106Ileus (HP:0002595)1.82535120
107Hypoplastic iliac wings (HP:0002866)1.80770931
108Absence seizures (HP:0002121)1.80386539
109Abnormality of potassium homeostasis (HP:0011042)1.78812179
110Hypoglycemic seizures (HP:0002173)1.78191253
111Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77428783
112Carpal bone hypoplasia (HP:0001498)1.75431864
113Abnormal gallbladder physiology (HP:0012438)1.75390007
114Cholecystitis (HP:0001082)1.75390007
115Aplasia/Hypoplasia of the lens (HP:0008063)1.73973435
116Postaxial foot polydactyly (HP:0001830)1.73813051
117Late onset (HP:0003584)1.73484349
118Scapular winging (HP:0003691)1.73044326
119Poor coordination (HP:0002370)1.72012689
120Hypothermia (HP:0002045)1.71753562
121Irregular epiphyses (HP:0010582)1.70305431
122Abnormality of the pons (HP:0007361)1.70015572
123Abnormality of the metopic suture (HP:0005556)1.69650914
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69635109
125Increased CSF lactate (HP:0002490)1.69358769
126Calf muscle hypertrophy (HP:0008981)1.68800805
127Decreased central vision (HP:0007663)1.68727196
128Chronic sinusitis (HP:0011109)1.68367758
129Abnormality of B cell number (HP:0010975)1.68214616
130Vaginal atresia (HP:0000148)1.67534491
131Intestinal polyp (HP:0005266)1.66770809
132Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66505640
133Pancreatic fibrosis (HP:0100732)1.65938793
134Dyschromatopsia (HP:0007641)1.65706170
135Genital tract atresia (HP:0001827)1.64486761
136Abnormality of the renal cortex (HP:0011035)1.58669715
137Postaxial hand polydactyly (HP:0001162)1.58478444
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.55645683
139Congenital hepatic fibrosis (HP:0002612)1.55573935
140Fibular hypoplasia (HP:0003038)1.53299016
141Stage 5 chronic kidney disease (HP:0003774)1.52838650
142Oculomotor apraxia (HP:0000657)1.48514939
143Renal dysplasia (HP:0000110)1.46352077
144Abnormality of permanent molar morphology (HP:0011071)1.44783476
145Abnormality of the dental root (HP:0006486)1.44783476
146Taurodontia (HP:0000679)1.44783476
147Cystic liver disease (HP:0006706)1.42277794
148Tubulointerstitial fibrosis (HP:0005576)1.42153922
149Abnormality of renal excretion (HP:0011036)1.41550697
150True hermaphroditism (HP:0010459)1.38272260
151Abnormality of the lower motor neuron (HP:0002366)1.37503054
152Supernumerary spleens (HP:0009799)1.36795805
153Short ribs (HP:0000773)1.36143220
154Facial cleft (HP:0002006)1.35664218
155Abnormality of the dental pulp (HP:0006479)1.34557144
156Abnormality of molar (HP:0011077)1.33479271
157Abnormality of molar morphology (HP:0011070)1.33479271
158Retinal dysplasia (HP:0007973)1.33378096
159Spastic tetraparesis (HP:0001285)1.31490357
160Abnormal drinking behavior (HP:0030082)1.31078687
161Polydipsia (HP:0001959)1.31078687
162Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30488616
163Absent epiphyses (HP:0010577)1.30488616
164Abnormality of ocular smooth pursuit (HP:0000617)1.28019119
165Breast carcinoma (HP:0003002)1.27375817
166Cerebellar dysplasia (HP:0007033)1.25930447
167Choroideremia (HP:0001139)1.25385505
168Pancreatic cysts (HP:0001737)1.25281387
169Heterotopia (HP:0002282)1.22818612
170Microglossia (HP:0000171)1.20531267
171Chronic hepatic failure (HP:0100626)1.20067706
172Abnormality of saccadic eye movements (HP:0000570)1.19596633
173Easy fatigability (HP:0003388)1.19354651
174Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19325935
175Type II lissencephaly (HP:0007260)1.19090999
176Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.18502486
177J-shaped sella turcica (HP:0002680)1.18021134
178Bundle branch block (HP:0011710)1.17810850
179Abnormality of dentin (HP:0010299)1.16726190
180Bile duct proliferation (HP:0001408)1.15872315
181Abnormal biliary tract physiology (HP:0012439)1.15872315
182Abnormality of the neuromuscular junction (HP:0003398)1.15301158
183Fatigable weakness (HP:0003473)1.15301158
184Bell-shaped thorax (HP:0001591)1.14987537
185Tongue fasciculations (HP:0001308)1.14009968
186Asymmetric septal hypertrophy (HP:0001670)1.12001822
187Vascular calcification (HP:0004934)1.10697161
188Impaired smooth pursuit (HP:0007772)1.09452657
189Type 2 muscle fiber atrophy (HP:0003554)1.08994744
190Decreased electroretinogram (ERG) amplitude (HP:0000654)1.08826893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.23181872
2PDK49.23181872
3LATS18.26920169
4PDK26.05928272
5LATS25.06781463
6TESK14.86885900
7FRK3.57151591
8PRKD33.47162843
9ICK3.14617088
10ZAK2.65857273
11NLK2.57848874
12MAP2K22.35632434
13ACVR1B2.27263368
14WNK42.00589613
15PTK2B1.87627160
16STK391.83355547
17MAPKAPK31.70351734
18NEK21.68117713
19GRK71.65605895
20MELK1.57386816
21STK161.56816264
22PNCK1.54303963
23STK381.39193752
24VRK21.36090562
25SCYL21.26451567
26NME11.24038875
27EIF2AK21.23152191
28BMPR1B1.21212840
29IRAK11.16609573
30KDR1.16092495
31PDK11.15368662
32TRPM71.06296905
33MAP3K21.03599874
34CSNK1A1L1.03041143
35MAP3K141.02773895
36TAOK31.02344814
37TNK21.00585600
38PRKAA20.99191430
39DYRK1B0.98245483
40DYRK30.94531065
41GRK10.94305262
42VRK10.90244979
43PLK40.89746467
44PASK0.86051712
45BRSK20.85210987
46STK30.82697039
47BCKDK0.81900203
48CHEK20.78127221
49TLK10.75643788
50TTK0.74355082
51TESK20.74123302
52MST40.71667471
53ADRBK20.71047526
54ADRBK10.70918353
55MAP3K120.68585620
56DAPK10.68415304
57GRK50.67232474
58MAP2K60.66393021
59CCNB10.65852117
60IRAK30.64299789
61MAPK150.63670906
62TYRO30.61918920
63WNK10.61539626
64PINK10.60728006
65DAPK20.60272208
66TGFBR10.59531035
67TRIM280.59132881
68LMTK20.58827977
69LIMK10.58656672
70PDPK10.55534171
71TAF10.55007212
72PIK3CG0.54964776
73WEE10.53775139
74FLT30.52074381
75STK38L0.50762683
76BRSK10.48162139
77CHEK10.47538190
78MARK30.47093171
79TGFBR20.46693696
80IRAK20.46545575
81CAMKK20.46374123
82MAP4K20.45999375
83NUAK10.44462074
84MYLK0.44459443
85MAP3K70.44399077
86NEK90.42191677
87RPS6KB20.41553275
88CSNK1G30.39951046
89ATR0.38565524
90MAP3K40.38310986
91BMX0.37656981
92ATM0.36900120
93STK110.35281773
94BUB10.35124712
95CSNK1G10.34498772
96PLK10.33844434
97CSF1R0.33563144
98CASK0.32808650
99PAK10.31897331
100TEC0.31583836
101CDC70.30620218
102RIPK40.30272578
103PRKCG0.28527472
104CDK120.27569225
105PRKCE0.26590786
106EIF2AK10.25323506
107PRKD10.24987175
108EEF2K0.24980320
109NEK60.24570897
110MUSK0.23949166
111FGFR20.22763942
112ITK0.22504040
113NTRK20.21354408
114CAMKK10.21012162
115MAP3K100.20826889
116BCR0.20804929
117OXSR10.19677537
118MTOR0.19630832
119PRKAA10.19337412
120BRAF0.17559158
121MAPK130.17200629
122RPS6KB10.17131234
123CSNK1G20.16625316
124PKN10.16616016
125CSNK2A10.15898677
126PLK20.15866171
127MARK20.15047135
128MAP2K10.14394019
129WNK30.14276527
130NEK10.13818730
131CDK150.13790477
132DYRK20.13589718
133INSRR0.13363268
134AKT20.13362682
135PAK20.12928862
136CDK140.12609841
137AURKA0.11516266
138PAK40.11458861
139CDK11A0.11424152
140PRKACG0.11363183
141CDK180.10987323
142PRKG10.10901127
143MAPKAPK50.10086107
144MAP3K50.09429842
145CSNK2A20.09305827
146MINK10.09050920
147EIF2AK30.08407177
148YES10.07631256
149PRKCZ0.07127764
150CDK20.06540079
151PRKG20.05985565
152CDK10.05717026
153CAMK1G0.05365052
154STK100.04934620
155GSK3B0.04358280
156CSNK1D0.04347451
157SRPK10.03034521
158CAMK2A0.02345356
159PRKCA0.02221827
160PRKCB0.01963144
161PLK30.01873768
162MAPK80.01339193
163EGFR0.01146637
164PRKDC0.00967239
165RPS6KA30.00167521
166RIPK10.00032472
167PIM1-0.0113575
168PRKCQ-0.0069764
169PRKACA-0.0054609
170RPS6KA1-0.0030556

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.59090056
2Vitamin B6 metabolism_Homo sapiens_hsa007505.50677579
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.43523067
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.21487599
5Pyruvate metabolism_Homo sapiens_hsa006204.08583170
6Maturity onset diabetes of the young_Homo sapiens_hsa049503.81036518
7Propanoate metabolism_Homo sapiens_hsa006403.44612265
8Fatty acid biosynthesis_Homo sapiens_hsa000613.36865448
9Basal transcription factors_Homo sapiens_hsa030222.83814896
10Glucagon signaling pathway_Homo sapiens_hsa049222.82153088
11Phototransduction_Homo sapiens_hsa047442.75377054
12Pentose phosphate pathway_Homo sapiens_hsa000302.59924007
13Selenocompound metabolism_Homo sapiens_hsa004502.44353117
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.37294416
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.27901457
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27647844
17One carbon pool by folate_Homo sapiens_hsa006702.26477582
18Linoleic acid metabolism_Homo sapiens_hsa005912.24171466
19Homologous recombination_Homo sapiens_hsa034402.21161577
20Sphingolipid metabolism_Homo sapiens_hsa006002.16482121
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13062878
22Oxidative phosphorylation_Homo sapiens_hsa001902.11799148
23Oocyte meiosis_Homo sapiens_hsa041141.94365228
24Fructose and mannose metabolism_Homo sapiens_hsa000511.90620866
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90588333
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86097173
27Phenylalanine metabolism_Homo sapiens_hsa003601.81341593
28Fanconi anemia pathway_Homo sapiens_hsa034601.80145700
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76505434
30Glycerolipid metabolism_Homo sapiens_hsa005611.76496829
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.74956400
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64951716
33PPAR signaling pathway_Homo sapiens_hsa033201.62844738
34Carbon metabolism_Homo sapiens_hsa012001.59477784
35Amphetamine addiction_Homo sapiens_hsa050311.55728371
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45117217
37Nicotine addiction_Homo sapiens_hsa050331.44630743
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34150143
39Tyrosine metabolism_Homo sapiens_hsa003501.33524921
40Purine metabolism_Homo sapiens_hsa002301.32606958
41Tryptophan metabolism_Homo sapiens_hsa003801.31953923
42Nitrogen metabolism_Homo sapiens_hsa009101.31690914
43Huntingtons disease_Homo sapiens_hsa050161.26912863
44Biosynthesis of amino acids_Homo sapiens_hsa012301.25474129
45Butanoate metabolism_Homo sapiens_hsa006501.24263210
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23388076
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21791859
48Collecting duct acid secretion_Homo sapiens_hsa049661.21603423
49Renin secretion_Homo sapiens_hsa049241.20142217
50Morphine addiction_Homo sapiens_hsa050321.19306843
51Cardiac muscle contraction_Homo sapiens_hsa042601.18344815
52RNA transport_Homo sapiens_hsa030131.15830052
53Parkinsons disease_Homo sapiens_hsa050121.14584716
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13666300
55Mineral absorption_Homo sapiens_hsa049781.13394576
56beta-Alanine metabolism_Homo sapiens_hsa004101.12411392
57Protein export_Homo sapiens_hsa030601.08297838
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07233902
59Nucleotide excision repair_Homo sapiens_hsa034201.05999353
60Glycerophospholipid metabolism_Homo sapiens_hsa005641.05033313
61Glutathione metabolism_Homo sapiens_hsa004801.04016638
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03380017
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01743945
64Histidine metabolism_Homo sapiens_hsa003400.98871689
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98206947
66Fat digestion and absorption_Homo sapiens_hsa049750.97675124
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97178981
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94393969
69RNA polymerase_Homo sapiens_hsa030200.94005502
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93510950
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91622274
72mRNA surveillance pathway_Homo sapiens_hsa030150.90592571
73Fatty acid degradation_Homo sapiens_hsa000710.90484913
74Non-homologous end-joining_Homo sapiens_hsa034500.90282136
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.90236879
76N-Glycan biosynthesis_Homo sapiens_hsa005100.89684156
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88850215
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87596904
79Dorso-ventral axis formation_Homo sapiens_hsa043200.85899716
80Ether lipid metabolism_Homo sapiens_hsa005650.84429903
81Peroxisome_Homo sapiens_hsa041460.84220003
82Antigen processing and presentation_Homo sapiens_hsa046120.83804333
83Chemical carcinogenesis_Homo sapiens_hsa052040.81494181
84Fatty acid metabolism_Homo sapiens_hsa012120.80932552
85Synaptic vesicle cycle_Homo sapiens_hsa047210.80696322
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80425938
87Insulin secretion_Homo sapiens_hsa049110.79417862
88Long-term potentiation_Homo sapiens_hsa047200.73392918
89Folate biosynthesis_Homo sapiens_hsa007900.72973906
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68805838
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64948366
92Base excision repair_Homo sapiens_hsa034100.63615445
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63451511
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62259830
95GABAergic synapse_Homo sapiens_hsa047270.61750200
96Pyrimidine metabolism_Homo sapiens_hsa002400.61486884
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60174479
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59190679
99Fatty acid elongation_Homo sapiens_hsa000620.59093312
100Retinol metabolism_Homo sapiens_hsa008300.57894205
101DNA replication_Homo sapiens_hsa030300.57334791
102Inositol phosphate metabolism_Homo sapiens_hsa005620.57266432
103ABC transporters_Homo sapiens_hsa020100.56282884
104Olfactory transduction_Homo sapiens_hsa047400.55581847
105Thyroid hormone synthesis_Homo sapiens_hsa049180.55464285
106Metabolic pathways_Homo sapiens_hsa011000.55285272
107Vitamin digestion and absorption_Homo sapiens_hsa049770.54178696
108Regulation of autophagy_Homo sapiens_hsa041400.54148521
109Proteasome_Homo sapiens_hsa030500.54059857
110Steroid biosynthesis_Homo sapiens_hsa001000.53688528
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.52987193
112Ovarian steroidogenesis_Homo sapiens_hsa049130.51810260
113Alzheimers disease_Homo sapiens_hsa050100.50713227
114Arginine and proline metabolism_Homo sapiens_hsa003300.50374254
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50320523
116Arachidonic acid metabolism_Homo sapiens_hsa005900.50015005
117Estrogen signaling pathway_Homo sapiens_hsa049150.48255688
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46726515
119Calcium signaling pathway_Homo sapiens_hsa040200.46131671
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46046650
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45413239
122Caffeine metabolism_Homo sapiens_hsa002320.44261494
123Type II diabetes mellitus_Homo sapiens_hsa049300.41587066
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.41031577
125Renin-angiotensin system_Homo sapiens_hsa046140.38593735
126Viral myocarditis_Homo sapiens_hsa054160.37906379
127Systemic lupus erythematosus_Homo sapiens_hsa053220.36721797
128Vibrio cholerae infection_Homo sapiens_hsa051100.36504449
129Legionellosis_Homo sapiens_hsa051340.35720935
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35680192
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35367518
132AMPK signaling pathway_Homo sapiens_hsa041520.35135440
133Cell cycle_Homo sapiens_hsa041100.34929565
134Sulfur metabolism_Homo sapiens_hsa009200.34812101
135Bile secretion_Homo sapiens_hsa049760.34156134
136Starch and sucrose metabolism_Homo sapiens_hsa005000.33636290
137Serotonergic synapse_Homo sapiens_hsa047260.33181781
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32929281
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32252045
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29077290
141RNA degradation_Homo sapiens_hsa030180.28502244
142Type I diabetes mellitus_Homo sapiens_hsa049400.28330673
143Intestinal immune network for IgA production_Homo sapiens_hsa046720.27911563
144Protein digestion and absorption_Homo sapiens_hsa049740.27297368
145VEGF signaling pathway_Homo sapiens_hsa043700.25104484
146Circadian entrainment_Homo sapiens_hsa047130.24939518
147Sulfur relay system_Homo sapiens_hsa041220.24555470
148Taste transduction_Homo sapiens_hsa047420.23378391
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.21303662
150Pancreatic secretion_Homo sapiens_hsa049720.20089708
151Alcoholism_Homo sapiens_hsa050340.19555833
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19437619
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19347702
154Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17117543
155Salivary secretion_Homo sapiens_hsa049700.16658861
156Mismatch repair_Homo sapiens_hsa034300.16110940
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15142821
158Hedgehog signaling pathway_Homo sapiens_hsa043400.14760439
159B cell receptor signaling pathway_Homo sapiens_hsa046620.14646428
160cAMP signaling pathway_Homo sapiens_hsa040240.14047348
161Epstein-Barr virus infection_Homo sapiens_hsa051690.13917507
162Viral carcinogenesis_Homo sapiens_hsa052030.12866413
163Endocytosis_Homo sapiens_hsa041440.12592736

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