SPATA31E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.40535192
2chromosome condensation (GO:0030261)9.17454109
3DNA packaging (GO:0006323)8.86700619
4response to pheromone (GO:0019236)8.63887000
5plasma membrane fusion (GO:0045026)8.62607960
6microtubule depolymerization (GO:0007019)8.46039286
7spermatid nucleus differentiation (GO:0007289)8.29639798
8spermatid development (GO:0007286)8.27891821
9single strand break repair (GO:0000012)8.09624951
10sperm-egg recognition (GO:0035036)7.57841840
11multicellular organism reproduction (GO:0032504)7.24970337
12protein polyglutamylation (GO:0018095)7.18488830
13negative regulation of inclusion body assembly (GO:0090084)6.95531899
14sexual reproduction (GO:0019953)6.90797174
15microtubule polymerization or depolymerization (GO:0031109)6.90725965
16reproduction (GO:0000003)6.90418491
17rRNA methylation (GO:0031167)6.88654976
18binding of sperm to zona pellucida (GO:0007339)6.88271986
19calcium ion-dependent exocytosis (GO:0017156)6.67900426
20protein targeting to Golgi (GO:0000042)6.66353688
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.40538277
22establishment of protein localization to Golgi (GO:0072600)6.37672216
23cell-cell recognition (GO:0009988)6.22576094
24retrograde transport, vesicle recycling within Golgi (GO:0000301)6.20102291
25axonemal dynein complex assembly (GO:0070286)6.15375416
26microtubule severing (GO:0051013)6.12967456
27* spermatogenesis (GO:0007283)6.04141962
28* male gamete generation (GO:0048232)6.02047726
29phosphatidylethanolamine metabolic process (GO:0046337)5.90685268
30rRNA modification (GO:0000154)5.78877066
31cellular ketone body metabolic process (GO:0046950)5.73051406
32* gamete generation (GO:0007276)5.50082020
33centriole replication (GO:0007099)5.49709051
34regulation of cilium movement (GO:0003352)5.44955705
35positive regulation of Rab GTPase activity (GO:0032851)5.19682277
36regulation of Rab GTPase activity (GO:0032313)5.19682277
37ketone body metabolic process (GO:1902224)5.03780210
38regulation of inclusion body assembly (GO:0090083)5.01849319
39single fertilization (GO:0007338)4.99881385
40RNA destabilization (GO:0050779)4.94449611
41motile cilium assembly (GO:0044458)4.88429604
42centriole assembly (GO:0098534)4.87048489
43protein localization to Golgi apparatus (GO:0034067)4.82489430
44cell wall macromolecule catabolic process (GO:0016998)4.78307150
45cilium or flagellum-dependent cell motility (GO:0001539)4.67670431
46germ cell development (GO:0007281)4.60902958
47regulation of transcription involved in cell fate commitment (GO:0060850)4.60476901
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55398024
49cell wall macromolecule metabolic process (GO:0044036)4.50757846
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.41741775
51chromatin silencing (GO:0006342)4.40733179
52* multicellular organismal reproductive process (GO:0048609)4.40617454
53regulation of centriole replication (GO:0046599)4.24134615
54seminiferous tubule development (GO:0072520)4.22694729
55epithelial cilium movement (GO:0003351)4.16454012
56fertilization (GO:0009566)4.16334115
57nucleus organization (GO:0006997)4.15920658
58musculoskeletal movement (GO:0050881)3.78348195
59multicellular organismal movement (GO:0050879)3.78348195
60regulation of microtubule-based movement (GO:0060632)3.75036454
61organic cation transport (GO:0015695)3.69192144
62membrane protein intracellular domain proteolysis (GO:0031293)3.68840104
63polyamine biosynthetic process (GO:0006596)3.66899805
64glycerol ether metabolic process (GO:0006662)3.66536876
65response to acidic pH (GO:0010447)3.65353971
66cilium movement (GO:0003341)3.62816466
67coenzyme catabolic process (GO:0009109)3.50387802
68negative regulation of Rho protein signal transduction (GO:0035024)3.46175554
69regulation of T-helper 2 cell differentiation (GO:0045628)3.45893232
70glomerular visceral epithelial cell development (GO:0072015)3.45569504
71ether metabolic process (GO:0018904)3.37336916
72cellular response to pH (GO:0071467)3.36874855
73peptidyl-threonine dephosphorylation (GO:0035970)3.35025972
74glomerular epithelial cell development (GO:0072310)3.32030472
75cerebral cortex neuron differentiation (GO:0021895)3.25923811
76homeostasis of number of cells within a tissue (GO:0048873)3.15101483
77NAD biosynthetic process (GO:0009435)3.13876597
78cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08413772
79protein depolymerization (GO:0051261)3.07029721
80nucleosome disassembly (GO:0006337)3.05325240
81protein-DNA complex disassembly (GO:0032986)3.05325240
82multicellular organismal development (GO:0007275)3.04313487
83regulation of interleukin-13 production (GO:0032656)3.01102339
84histone H3-K9 demethylation (GO:0033169)2.98736611
85negative regulation of gene expression, epigenetic (GO:0045814)2.96632643
86cell recognition (GO:0008037)2.92600740
87microtubule nucleation (GO:0007020)2.92045701
88male meiosis I (GO:0007141)2.84688401
89mesenchymal cell differentiation involved in renal system development (GO:2001012)2.80035907
90mesenchymal cell differentiation involved in kidney development (GO:0072161)2.80035907
91cell differentiation involved in metanephros development (GO:0072202)2.70449675
92DNA conformation change (GO:0071103)2.68975430
93positive regulation of type 2 immune response (GO:0002830)2.66985389
94positive regulation of guanylate cyclase activity (GO:0031284)2.66592949
95Golgi to endosome transport (GO:0006895)2.64079671
96cranial nerve morphogenesis (GO:0021602)2.62710286
97mitochondrial fission (GO:0000266)2.62267165
98acrosome reaction (GO:0007340)12.2877977
99sperm motility (GO:0030317)12.1195834
100fusion of sperm to egg plasma membrane (GO:0007342)11.4285193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.88607832
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.73180511
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.71507096
4POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.46103564
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46103564
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.16889053
7CBP_20019798_ChIP-Seq_JUKART_Human2.15790921
8IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.15790921
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15235674
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.14619593
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06977041
12EZH2_22144423_ChIP-Seq_EOC_Human2.05843453
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94042735
14RAC3_21632823_ChIP-Seq_H3396_Human1.89169171
15DROSHA_22980978_ChIP-Seq_HELA_Human1.85836984
16ERA_21632823_ChIP-Seq_H3396_Human1.85128596
17EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.82101901
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.80858310
19NANOG_20526341_ChIP-Seq_ESCs_Human1.80428898
20EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.79905227
21CTCF_27219007_Chip-Seq_Bcells_Human1.76481747
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.75130015
23FUS_26573619_Chip-Seq_HEK293_Human1.72003253
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71673179
25BCL6_27268052_Chip-Seq_Bcells_Human1.71515400
26YY1_22570637_ChIP-Seq_MALME-3M_Human1.65611787
27TAF2_19829295_ChIP-Seq_ESCs_Human1.63302965
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61049563
29MYC_19829295_ChIP-Seq_ESCs_Human1.60089990
30E2F1_20622854_ChIP-Seq_HELA_Human1.59613232
31BCOR_27268052_Chip-Seq_Bcells_Human1.58182060
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57964769
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57082328
34SMC4_20622854_ChIP-Seq_HELA_Human1.56241805
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.54504856
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51540745
37CTCF_20526341_ChIP-Seq_ESCs_Human1.49919095
38PHF8_20622854_ChIP-Seq_HELA_Human1.49890836
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.49454481
40P68_20966046_ChIP-Seq_HELA_Human1.47598993
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47328318
42OCT4_20526341_ChIP-Seq_ESCs_Human1.46572639
43LXR_22292898_ChIP-Seq_THP-1_Human1.46386720
44TP63_22573176_ChIP-Seq_HFKS_Human1.45908934
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41469569
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41457840
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40280077
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.38922098
49AR_25329375_ChIP-Seq_VCAP_Human1.38374330
50ER_23166858_ChIP-Seq_MCF-7_Human1.38224140
51P300_27268052_Chip-Seq_Bcells_Human1.36699087
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36600648
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.35661476
54ERG_20517297_ChIP-Seq_VCAP_Human1.34196278
55RBPJ_21746931_ChIP-Seq_IB4_Human1.32616905
56CBX2_22325352_ChIP-Seq_293T-Rex_Human1.32529718
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32424107
58TP53_18474530_ChIP-ChIP_U2OS_Human1.31929154
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.31358597
60P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28751385
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28490619
62SMAD3_21741376_ChIP-Seq_ESCs_Human1.28148200
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27883445
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.26744574
65ETV1_20927104_ChIP-Seq_GIST48_Human1.25321362
66KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24454824
67SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24195139
68CEBPB_22108803_ChIP-Seq_LS180_Human1.23920354
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.20789273
70SA1_27219007_Chip-Seq_Bcells_Human1.16152859
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15618407
72NFYB_21822215_ChIP-Seq_K562_Human1.15472049
73P53_21459846_ChIP-Seq_SAOS-2_Human1.14925655
74TAF15_26573619_Chip-Seq_HEK293_Human1.14347091
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13796347
76RUNX_20019798_ChIP-Seq_JUKART_Human1.12853996
77SMRT_27268052_Chip-Seq_Bcells_Human1.09302849
78RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09106671
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09014842
80P300_19829295_ChIP-Seq_ESCs_Human1.08834330
81TBL1_22424771_ChIP-Seq_293T_Human1.08681433
82GATA6_21074721_ChIP-Seq_CACO-2_Human1.08591703
83PHF8_20622853_ChIP-Seq_HELA_Human1.07888601
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.07847226
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.07495711
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06336159
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.05532312
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05161712
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.03856474
90NANOG_19829295_ChIP-Seq_ESCs_Human1.02357761
91SOX2_19829295_ChIP-Seq_ESCs_Human1.02357761
92VDR_24787735_ChIP-Seq_THP-1_Human1.01583671
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01109736
94CSB_26484114_Chip-Seq_FIBROBLAST_Human1.00904461
95OCT1_27270436_Chip-Seq_PROSTATE_Human1.00429598
96NFYA_21822215_ChIP-Seq_K562_Human1.00359400
97ZNF274_21170338_ChIP-Seq_K562_Hela0.99698157
98RUNX2_22187159_ChIP-Seq_PCA_Human0.97817759
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97668264
100KLF5_25053715_ChIP-Seq_YYC3_Human0.97649748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.79088945
2MP0005377_hearing/vestibular/ear_phenot5.79088945
3MP0005670_abnormal_white_adipose4.51050078
4MP0003698_abnormal_male_reproductive4.38269944
5MP0001929_abnormal_gametogenesis3.77980031
6MP0001348_abnormal_lacrimal_gland3.10426308
7MP0002161_abnormal_fertility/fecundity2.46289537
8MP0003646_muscle_fatigue2.27395251
9MP0000678_abnormal_parathyroid_gland2.20823925
10MP0004510_myositis2.13003686
11MP0005410_abnormal_fertilization12.3567359
12MP0003718_maternal_effect1.96522039
13MP0003011_delayed_dark_adaptation1.95159534
14MP0001485_abnormal_pinna_reflex1.74607459
15MP0002210_abnormal_sex_determination1.68764156
16MP0002132_abnormal_respiratory_system1.64077985
17MP0005379_endocrine/exocrine_gland_phen1.63729965
18MP0005310_abnormal_salivary_gland1.61348254
19MP0005451_abnormal_body_composition1.47186896
20MP0001486_abnormal_startle_reflex1.40537962
21MP0002282_abnormal_trachea_morphology1.39715919
22MP0001145_abnormal_male_reproductive1.35407335
23MP0002234_abnormal_pharynx_morphology1.34937378
24MP0000653_abnormal_sex_gland1.30121156
25MP0002138_abnormal_hepatobiliary_system1.26327013
26MP0005423_abnormal_somatic_nervous1.26277910
27MP0003879_abnormal_hair_cell1.26074250
28MP0002822_catalepsy1.20373632
29MP0001765_abnormal_ion_homeostasis1.19959407
30MP0002249_abnormal_larynx_morphology1.16587184
31MP0002735_abnormal_chemical_nociception1.15081477
32MP0004742_abnormal_vestibular_system1.13247618
33MP0001963_abnormal_hearing_physiology1.10075904
34MP0009053_abnormal_anal_canal1.09947911
35MP0004859_abnormal_synaptic_plasticity1.04672244
36MP0005248_abnormal_Harderian_gland1.03339255
37MP0005666_abnormal_adipose_tissue1.03077372
38MP0000026_abnormal_inner_ear1.00746434
39MP0005167_abnormal_blood-brain_barrier0.96346285
40MP0000534_abnormal_ureter_morphology0.94418406
41MP0001968_abnormal_touch/_nociception0.91255019
42MP0009115_abnormal_fat_cell0.90313960
43MP0002229_neurodegeneration0.87817776
44MP0005395_other_phenotype0.85622494
45MP0009764_decreased_sensitivity_to0.82930446
46MP0003303_peritoneal_inflammation0.80991120
47MP0002127_abnormal_cardiovascular_syste0.79765608
48MP0005636_abnormal_mineral_homeostasis0.76639950
49MP0000955_abnormal_spinal_cord0.74466261
50MP0005375_adipose_tissue_phenotype0.73312128
51MP0008569_lethality_at_weaning0.71599626
52MP0002067_abnormal_sensory_capabilities0.69430971
53MP0005551_abnormal_eye_electrophysiolog0.69182856
54MP0002254_reproductive_system_inflammat0.67282780
55MP0002733_abnormal_thermal_nociception0.65592270
56MP0005253_abnormal_eye_physiology0.64529464
57MP0005535_abnormal_body_temperature0.64203209
58MP0001501_abnormal_sleep_pattern0.63421501
59MP0000681_abnormal_thyroid_gland0.61647605
60MP0005083_abnormal_biliary_tract0.60518315
61MP0008877_abnormal_DNA_methylation0.59702321
62MP0002653_abnormal_ependyma_morphology0.59489071
63MP0000049_abnormal_middle_ear0.58147425
64MP0002557_abnormal_social/conspecific_i0.58073795
65MP0004085_abnormal_heartbeat0.57765604
66MP0001905_abnormal_dopamine_level0.57467103
67MP0001879_abnormal_lymphatic_vessel0.56352632
68MP0003137_abnormal_impulse_conducting0.56117327
69MP0009785_altered_susceptibility_to0.54540479
70MP0009697_abnormal_copulation0.53388700
71MP0002572_abnormal_emotion/affect_behav0.50952517
72MP0001545_abnormal_hematopoietic_system0.47758234
73MP0005397_hematopoietic_system_phenotyp0.47758234
74MP0001970_abnormal_pain_threshold0.47412827
75MP0003091_abnormal_cell_migration0.46207681
76MP0000249_abnormal_blood_vessel0.45853106
77MP0009278_abnormal_bone_marrow0.45782279
78MP0000516_abnormal_urinary_system0.44508954
79MP0005367_renal/urinary_system_phenotyp0.44508954
80MP0008961_abnormal_basal_metabolism0.43781514
81MP0003172_abnormal_lysosome_physiology0.43213444
82MP0009745_abnormal_behavioral_response0.43023559
83MP0000230_abnormal_systemic_arterial0.43004856
84MP0001666_abnormal_nutrient_absorption0.42154480
85MP0005647_abnormal_sex_gland0.40899710
86MP0005166_decreased_susceptibility_to0.40775701
87MP0005595_abnormal_vascular_smooth0.39810699
88MP0001533_abnormal_skeleton_physiology0.39560598
89MP0001440_abnormal_grooming_behavior0.39418143
90MP0002272_abnormal_nervous_system0.37421415
91MP0003699_abnormal_female_reproductive0.37007896
92MP0005084_abnormal_gallbladder_morpholo0.36956799
93MP0003631_nervous_system_phenotype0.36445843
94MP0002332_abnormal_exercise_endurance0.36225078
95MP0000470_abnormal_stomach_morphology0.35052993
96MP0008874_decreased_physiological_sensi0.34456447
97MP0003632_abnormal_nervous_system0.33885305
98MP0005391_vision/eye_phenotype0.33600631
99MP0000003_abnormal_adipose_tissue0.32136835
100MP0004484_altered_response_of0.31899269

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.61165336
2Absent/shortened dynein arms (HP:0200106)6.15055156
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.15055156
4Asymmetric septal hypertrophy (HP:0001670)5.57689286
5Bony spicule pigmentary retinopathy (HP:0007737)5.07434974
6Attenuation of retinal blood vessels (HP:0007843)5.00286874
7Tubulointerstitial nephritis (HP:0001970)4.99865919
8Chronic hepatic failure (HP:0100626)4.85055620
9Abnormal ciliary motility (HP:0012262)4.65202581
10Abnormal respiratory epithelium morphology (HP:0012253)4.48356777
11Abnormal respiratory motile cilium morphology (HP:0005938)4.48356777
12Abnormal respiratory motile cilium physiology (HP:0012261)4.47900580
13Bell-shaped thorax (HP:0001591)4.39301790
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.38044585
15Nasal polyposis (HP:0100582)4.37259287
16Hyperkalemia (HP:0002153)4.23360482
17Male infertility (HP:0003251)4.23225701
18Infertility (HP:0000789)4.20955552
19Enlarged epiphyses (HP:0010580)4.16757869
20Resting tremor (HP:0002322)4.16647820
21Abnormality of macular pigmentation (HP:0008002)4.12452802
22Cone-rod dystrophy (HP:0000548)3.95505143
23Abnormal rod and cone electroretinograms (HP:0008323)3.94111925
24Potter facies (HP:0002009)3.83041244
25Facial shape deformation (HP:0011334)3.83041244
26Hypoplastic ischia (HP:0003175)3.83022410
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.79970679
28Abnormality of the nasal mucosa (HP:0000433)3.61729994
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.38593455
30Impulsivity (HP:0100710)3.38385394
31Abnormality of the ischium (HP:0003174)3.37279645
32Azoospermia (HP:0000027)3.33449170
33Abnormal spermatogenesis (HP:0008669)3.33103428
34Progressive sensorineural hearing impairment (HP:0000408)3.29885250
35Hypoplasia of the thymus (HP:0000778)3.25911850
36Hypoalphalipoproteinemia (HP:0003233)3.12433561
37Generalized aminoaciduria (HP:0002909)3.04175297
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.99346220
39Postural instability (HP:0002172)2.93822690
40Nephronophthisis (HP:0000090)2.77613136
41Portal hypertension (HP:0001409)2.76921366
42Abnormal urine output (HP:0012590)2.68564134
43Renovascular hypertension (HP:0100817)2.64020340
44Unilateral renal agenesis (HP:0000122)2.63773078
45Rhinitis (HP:0012384)2.62832737
46Abnormality of the costochondral junction (HP:0000919)2.62510520
47Truncal obesity (HP:0001956)2.59434101
48Abnormality of dental color (HP:0011073)2.56550769
49Progressive cerebellar ataxia (HP:0002073)2.54747382
50Amelogenesis imperfecta (HP:0000705)2.54595253
51Stage 5 chronic kidney disease (HP:0003774)2.53950271
52Abnormality of the hepatic vasculature (HP:0006707)2.51733578
53Abnormality of potassium homeostasis (HP:0011042)2.49005584
54Abnormality of the aortic arch (HP:0012303)2.42642576
55Tubulointerstitial abnormality (HP:0001969)2.42080610
56Insulin-resistant diabetes mellitus (HP:0000831)2.37916903
57Menstrual irregularities (HP:0000858)2.35313628
58Renal dysplasia (HP:0000110)2.35202953
59Flattened epiphyses (HP:0003071)2.32459868
60Abnormality of the renal medulla (HP:0100957)2.31870021
61Congenital malformation of the right heart (HP:0011723)2.30271806
62Double outlet right ventricle (HP:0001719)2.30271806
63Abnormality of renal excretion (HP:0011036)2.29917381
64Epiphyseal dysplasia (HP:0002656)2.28298865
65Abnormal drinking behavior (HP:0030082)2.23429189
66Polydipsia (HP:0001959)2.23429189
67Widely patent fontanelles and sutures (HP:0004492)2.18747885
68Recurrent pneumonia (HP:0006532)2.18739833
69Osteomalacia (HP:0002749)2.14198154
70Polyuria (HP:0000103)2.07282512
71Progressive hearing impairment (HP:0001730)2.05205597
72Abnormality of the parathyroid morphology (HP:0011766)2.03238082
73Focal segmental glomerulosclerosis (HP:0000097)2.02910709
74Hypophosphatemic rickets (HP:0004912)2.01361126
75Insidious onset (HP:0003587)1.99612738
76Termporal pattern (HP:0011008)1.99612738
77Abnormality of the epiphysis of the femoral head (HP:0010574)1.97879763
78Bronchiectasis (HP:0002110)1.96380367
79Protuberant abdomen (HP:0001538)1.95055089
80Ventricular tachycardia (HP:0004756)1.93177436
81Absent epiphyses (HP:0010577)1.93066652
82Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93066652
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90145001
84Decreased central vision (HP:0007663)1.87993010
85Hyperuricemia (HP:0002149)1.87951023
86Increased purine levels (HP:0004368)1.87951023
87Flat capital femoral epiphysis (HP:0003370)1.85642099
88Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.84847019
89Abnormality of femoral epiphyses (HP:0006499)1.84847019
90Myokymia (HP:0002411)1.84213388
91Abnormality of the pubic bones (HP:0003172)1.82994415
92Intellectual disability, moderate (HP:0002342)1.80113320
93Tetany (HP:0001281)1.80095543
94Optic nerve hypoplasia (HP:0000609)1.79041599
95Hyponatremia (HP:0002902)1.78215274
96Renal Fanconi syndrome (HP:0001994)1.77643315
97Chronic bronchitis (HP:0004469)1.77077317
98Abnormality of the femoral head (HP:0003368)1.75488582
99Spastic paraparesis (HP:0002313)1.74886364
100Recurrent corneal erosions (HP:0000495)1.72980295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.31154183
2TESK15.88067993
3DDR25.51134053
4INSRR4.17054500
5MAP4K23.28561833
6STK383.26052269
7PNCK3.15401534
8PLK23.00162709
9BRD42.93122758
10CAMK1G2.40689228
11MAPK152.32602701
12STK38L2.28345448
13PRKD32.11942138
14MST1R1.92055149
15PIK3CG1.67692417
16DYRK1B1.56516195
17PDPK11.48131607
18WNK11.43623898
19PDK11.40215851
20CDK71.16182916
21NEK61.15236380
22CDK121.14104143
23TYRO31.05126109
24MAP3K111.03013232
25CAMK1D1.01712028
26PTK2B0.99500583
27KSR20.95847874
28MAP3K90.95200106
29LATS20.82592466
30AKT30.78074560
31ACVR1B0.75841809
32SIK20.74539386
33BRAF0.68571409
34BMPR1B0.65238514
35RPS6KA20.64620563
36PRKG20.63511517
37PRKG10.63212181
38RIPK40.60525539
39GRK70.60121357
40RPS6KA10.59718763
41PRKAA20.57795077
42MAP2K20.54035219
43UHMK10.51645758
44CAMK10.48496025
45ROCK10.46629006
46TESK20.46558983
47JAK30.45835405
48MAP3K20.44929092
49ADRBK20.43597332
50CDK40.43337845
51CDK30.43245246
52MAP3K80.43207911
53TIE10.42432510
54IKBKB0.41162067
55RPS6KA60.39720980
56GSK3B0.39497032
57MAPK10.38193171
58CHUK0.38187153
59CDK20.37812381
60WNK40.36997065
61RPS6KC10.36795733
62RPS6KL10.36795733
63MAP3K10.36764693
64RIPK10.36180386
65DYRK30.34687804
66BLK0.34416225
67CDK10.32714667
68SGK4940.31988514
69SGK2230.31988514
70ARAF0.31700673
71MAPK80.30746567
72PRKCZ0.30047109
73MOS0.29508590
74PKN10.28969216
75MAP3K40.27673023
76PRKCG0.27347613
77CAMK40.27289224
78MTOR0.27002999
79STK390.26203222
80NTRK30.24886125
81LATS10.24454967
82MUSK0.23069158
83MET0.22952353
84MARK10.22452773
85PRKCB0.19703206
86MAPK140.18666677
87CHEK10.17118229
88MARK20.16818247
89SGK10.15217091
90MAPK100.13142131
91BRSK10.12861913
92AKT10.12159090
93ABL20.12100101
94ICK0.12044321
95MAPK110.11988419
96ZAK0.10662652
97BRSK20.08585629
98PRKACA0.07528979
99MINK10.06747552
100CAMK2A0.06633804

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.97695398
2Fatty acid biosynthesis_Homo sapiens_hsa000616.62242765
3Olfactory transduction_Homo sapiens_hsa047403.44971455
4Butanoate metabolism_Homo sapiens_hsa006502.71051717
5Allograft rejection_Homo sapiens_hsa053302.24181118
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01004881
7Autoimmune thyroid disease_Homo sapiens_hsa053202.00130445
8Type I diabetes mellitus_Homo sapiens_hsa049401.88142850
9Graft-versus-host disease_Homo sapiens_hsa053321.84886543
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.84748629
11Dorso-ventral axis formation_Homo sapiens_hsa043201.79199956
12Type II diabetes mellitus_Homo sapiens_hsa049301.69114720
13Fatty acid degradation_Homo sapiens_hsa000711.67203673
14Antigen processing and presentation_Homo sapiens_hsa046121.61845797
15Fatty acid metabolism_Homo sapiens_hsa012121.56884470
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.51092506
17Phenylalanine metabolism_Homo sapiens_hsa003601.42732811
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38293350
19Taste transduction_Homo sapiens_hsa047421.34642930
20Viral myocarditis_Homo sapiens_hsa054161.31124688
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29194399
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28586460
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18263057
24RNA transport_Homo sapiens_hsa030131.17793316
25Influenza A_Homo sapiens_hsa051641.13560777
26Phototransduction_Homo sapiens_hsa047441.07404916
27PPAR signaling pathway_Homo sapiens_hsa033201.06529103
28Endocytosis_Homo sapiens_hsa041441.04929782
29Arginine and proline metabolism_Homo sapiens_hsa003300.99717261
30Protein digestion and absorption_Homo sapiens_hsa049740.99020672
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98975730
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90999999
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86500277
34ABC transporters_Homo sapiens_hsa020100.85161312
35Renin-angiotensin system_Homo sapiens_hsa046140.84211651
36Primary bile acid biosynthesis_Homo sapiens_hsa001200.81952191
37Salivary secretion_Homo sapiens_hsa049700.79184431
38Calcium signaling pathway_Homo sapiens_hsa040200.74230210
39Morphine addiction_Homo sapiens_hsa050320.73707568
40Synaptic vesicle cycle_Homo sapiens_hsa047210.68616076
41cAMP signaling pathway_Homo sapiens_hsa040240.68402298
42Selenocompound metabolism_Homo sapiens_hsa004500.63650394
43Inositol phosphate metabolism_Homo sapiens_hsa005620.63221123
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63142475
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62581871
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.62320305
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.61208192
48Fat digestion and absorption_Homo sapiens_hsa049750.61131116
49Legionellosis_Homo sapiens_hsa051340.53406756
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53243988
51Nicotine addiction_Homo sapiens_hsa050330.51526136
52Cardiac muscle contraction_Homo sapiens_hsa042600.50833357
53Glycerolipid metabolism_Homo sapiens_hsa005610.50806561
54VEGF signaling pathway_Homo sapiens_hsa043700.49601774
55Estrogen signaling pathway_Homo sapiens_hsa049150.48918726
56Arginine biosynthesis_Homo sapiens_hsa002200.48794831
57Tyrosine metabolism_Homo sapiens_hsa003500.48617187
58Circadian entrainment_Homo sapiens_hsa047130.47851515
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47209646
60Toxoplasmosis_Homo sapiens_hsa051450.46448112
61Hedgehog signaling pathway_Homo sapiens_hsa043400.46349635
62Acute myeloid leukemia_Homo sapiens_hsa052210.46289988
63African trypanosomiasis_Homo sapiens_hsa051430.44907224
64MAPK signaling pathway_Homo sapiens_hsa040100.44133753
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43807852
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42936054
67Retinol metabolism_Homo sapiens_hsa008300.41862449
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40888126
69Herpes simplex infection_Homo sapiens_hsa051680.40654897
70Malaria_Homo sapiens_hsa051440.40126500
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.39148539
72Oocyte meiosis_Homo sapiens_hsa041140.37539849
73Asthma_Homo sapiens_hsa053100.35713209
74Glutamatergic synapse_Homo sapiens_hsa047240.35644510
75Tryptophan metabolism_Homo sapiens_hsa003800.34491656
76Bile secretion_Homo sapiens_hsa049760.34418615
77Prolactin signaling pathway_Homo sapiens_hsa049170.34266672
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31292651
79Serotonergic synapse_Homo sapiens_hsa047260.31140102
80Gastric acid secretion_Homo sapiens_hsa049710.31073234
81Purine metabolism_Homo sapiens_hsa002300.27952596
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27060444
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26916063
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.26630585
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25688012
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25593203
87Renin secretion_Homo sapiens_hsa049240.25475282
88Nitrogen metabolism_Homo sapiens_hsa009100.25350575
89Chemokine signaling pathway_Homo sapiens_hsa040620.24316723
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23948285
91Cholinergic synapse_Homo sapiens_hsa047250.23782609
92Tight junction_Homo sapiens_hsa045300.23699523
93Osteoclast differentiation_Homo sapiens_hsa043800.22353708
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20816463
95Viral carcinogenesis_Homo sapiens_hsa052030.20177472
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20130497
97Leishmaniasis_Homo sapiens_hsa051400.19655565
98Epstein-Barr virus infection_Homo sapiens_hsa051690.19517059
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.18220826
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18173902

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