SPATA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.78607264
2negative regulation of gene silencing (GO:0060969)8.44643660
3regulation of posttranscriptional gene silencing (GO:0060147)8.38916286
4regulation of gene silencing by miRNA (GO:0060964)8.38916286
5regulation of gene silencing by RNA (GO:0060966)8.38916286
6membrane tubulation (GO:0097320)6.44747869
7regulation of DNA damage checkpoint (GO:2000001)5.39601217
8macrophage activation involved in immune response (GO:0002281)5.36847538
9inner cell mass cell proliferation (GO:0001833)5.27137884
10positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)5.25234088
11positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)5.08084260
12positive regulation of cell cycle G2/M phase transition (GO:1902751)5.08084260
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88399458
14synaptic vesicle maturation (GO:0016188)4.75061803
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.67599700
16locomotory exploration behavior (GO:0035641)4.60633152
17neuronal action potential propagation (GO:0019227)4.54516175
18skeletal muscle tissue regeneration (GO:0043403)4.48744500
19cerebellar granule cell differentiation (GO:0021707)4.44560150
20myoblast migration (GO:0051451)4.40824649
21negative regulation of striated muscle cell apoptotic process (GO:0010664)4.37117294
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.29552775
23axon ensheathment in central nervous system (GO:0032291)4.25623449
24central nervous system myelination (GO:0022010)4.25623449
25regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.25190447
26synaptic vesicle exocytosis (GO:0016079)4.21963477
27microglial cell activation (GO:0001774)4.19256658
28autophagic vacuole fusion (GO:0000046)4.19193975
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.15965638
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.14247129
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.12262155
32phagocytosis, engulfment (GO:0006911)4.11902228
33glutamate secretion (GO:0014047)4.09888995
34intra-S DNA damage checkpoint (GO:0031573)4.08135415
35L-amino acid import (GO:0043092)4.06956538
36heart trabecula morphogenesis (GO:0061384)4.06607860
37regulation of synaptic vesicle exocytosis (GO:2000300)4.01079220
38glutamate receptor signaling pathway (GO:0007215)3.98947093
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95097684
40regulation of nucleobase-containing compound transport (GO:0032239)3.91145319
41vocalization behavior (GO:0071625)3.88472514
42neuron cell-cell adhesion (GO:0007158)3.83875831
43positive regulation of skeletal muscle tissue development (GO:0048643)3.78965480
44cellular potassium ion homeostasis (GO:0030007)3.78059897
45positive regulation of synapse maturation (GO:0090129)3.75027789
46negative regulation of neurotransmitter secretion (GO:0046929)3.73088135
47dendritic spine morphogenesis (GO:0060997)3.69452447
48sodium ion export (GO:0071436)3.69126492
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.68031207
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.67556170
51trabecula morphogenesis (GO:0061383)3.64786690
52macrophage chemotaxis (GO:0048246)3.61079696
53synaptic transmission, glutamatergic (GO:0035249)3.59561111
54spliceosomal tri-snRNP complex assembly (GO:0000244)3.58393236
55long-term memory (GO:0007616)3.58369804
56protein localization to synapse (GO:0035418)3.58128796
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57404335
58regulation of cell cycle checkpoint (GO:1901976)3.56357262
59regulation of glutamate receptor signaling pathway (GO:1900449)3.56012175
60regulation of female receptivity (GO:0045924)3.53836554
61mitotic chromosome condensation (GO:0007076)3.52507536
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50154237
63fatty-acyl-CoA biosynthetic process (GO:0046949)3.46420944
64adult walking behavior (GO:0007628)3.44453213
65amino acid import (GO:0043090)3.44100558
66regulation of RNA export from nucleus (GO:0046831)3.43438690
67cellular response to gamma radiation (GO:0071480)3.43119679
68regulation of synaptic vesicle transport (GO:1902803)3.41531792
69regulation of neuronal synaptic plasticity (GO:0048168)3.40912971
70exploration behavior (GO:0035640)3.40448261
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36056250
72regulation of striated muscle cell apoptotic process (GO:0010662)3.35547280
73positive regulation of DNA-templated transcription, elongation (GO:0032786)3.29388345
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29180877
75positive regulation of membrane potential (GO:0045838)3.27513030
76ensheathment of neurons (GO:0007272)3.27199512
77axon ensheathment (GO:0008366)3.27199512
78organelle membrane fusion (GO:0090174)3.26820324
79transmission of nerve impulse (GO:0019226)3.26590858
80regulation of gene silencing (GO:0060968)3.25129887
81neuron-neuron synaptic transmission (GO:0007270)3.24625192
82regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23217584
83myelination (GO:0042552)3.21153277
84layer formation in cerebral cortex (GO:0021819)3.19886682
85cell junction maintenance (GO:0034331)3.18802773
86neuromuscular process controlling posture (GO:0050884)3.18592349
87peptidyl-tyrosine autophosphorylation (GO:0038083)3.15750765
88synaptic vesicle endocytosis (GO:0048488)3.13749456
89cell migration in hindbrain (GO:0021535)3.11121504
90regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10523349
91long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.09689058
92female mating behavior (GO:0060180)3.06538394
93dendritic spine organization (GO:0097061)3.05196009
94defense response to Gram-negative bacterium (GO:0050829)3.05108833
95negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02242512
96regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.02003119
97regulation of ARF protein signal transduction (GO:0032012)3.01549018
98protein kinase C signaling (GO:0070528)3.01298099
99neuron recognition (GO:0008038)3.00540841
100regulation of synaptic plasticity (GO:0048167)2.99092576
101regulation of collateral sprouting (GO:0048670)2.98978875
102regulation of dendritic spine morphogenesis (GO:0061001)2.97843737
103gamma-aminobutyric acid transport (GO:0015812)2.95032798
104synaptic vesicle docking involved in exocytosis (GO:0016081)2.94776350
105cerebellar Purkinje cell differentiation (GO:0021702)2.91824917
106long-term synaptic potentiation (GO:0060291)2.91104262
107autophagic vacuole assembly (GO:0000045)2.90021959
108regulation of synapse maturation (GO:0090128)2.89547429
109cellular defense response (GO:0006968)2.89349144
110negative regulation of axonogenesis (GO:0050771)2.89193548
111regulation of postsynaptic membrane potential (GO:0060078)2.87990573
112signal complex assembly (GO:0007172)2.87468304
113very long-chain fatty acid metabolic process (GO:0000038)2.86866219
114axonal fasciculation (GO:0007413)2.86741825
115long-chain fatty acid biosynthetic process (GO:0042759)2.84768109
116regulation of synapse structural plasticity (GO:0051823)2.83966184
117regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.82826046
118cellular response to electrical stimulus (GO:0071257)2.82370722
119positive regulation of protein dephosphorylation (GO:0035307)2.82032529
120neuromuscular process controlling balance (GO:0050885)2.81874424
121positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81816687
122negative regulation of autophagy (GO:0010507)2.79284063
123myeloid cell activation involved in immune response (GO:0002275)2.78610324
124establishment of nucleus localization (GO:0040023)2.78405405
125negative regulation of macroautophagy (GO:0016242)2.78205092
126presynaptic membrane organization (GO:0097090)2.77868111
127thioester biosynthetic process (GO:0035384)2.77195892
128acyl-CoA biosynthetic process (GO:0071616)2.77195892
129vesicle targeting (GO:0006903)2.76391856
130neurotransmitter secretion (GO:0007269)2.75232004
131negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.74362988
132regulation of neurotransmitter secretion (GO:0046928)2.74353366
133long term synaptic depression (GO:0060292)2.74099302
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.73658463
135antigen processing and presentation of endogenous antigen (GO:0019883)2.73471336
136presynaptic membrane assembly (GO:0097105)2.73249945
137establishment of mitochondrion localization (GO:0051654)2.73144011
138dendrite morphogenesis (GO:0048813)2.72983637
139cell differentiation in hindbrain (GO:0021533)2.72929562
140positive regulation of dendritic spine development (GO:0060999)2.71568487
141membrane invagination (GO:0010324)2.70997477
142positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69280766
143macrophage activation (GO:0042116)2.68438098
144regulation of synaptic transmission, glutamatergic (GO:0051966)2.65402156
145cell communication by electrical coupling (GO:0010644)2.64988273
146nucleoside diphosphate catabolic process (GO:0009134)2.63438935
147neuronal ion channel clustering (GO:0045161)2.59998066
148potassium ion import (GO:0010107)2.58469993
149regulation of cell cycle G2/M phase transition (GO:1902749)2.58071771
150regulation of dendritic spine development (GO:0060998)2.57596006
151cerebral cortex radially oriented cell migration (GO:0021799)2.57531142
152regulation of DNA methylation (GO:0044030)2.56059798
153regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55299893
154membrane hyperpolarization (GO:0060081)2.55241489
155chemokine-mediated signaling pathway (GO:0070098)2.54902790
156oocyte development (GO:0048599)2.54799687
157regulation of voltage-gated calcium channel activity (GO:1901385)2.53249886
158response to pheromone (GO:0019236)2.53056150
159response to auditory stimulus (GO:0010996)2.52949571
160cellular component maintenance (GO:0043954)2.52827491
161regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52166743
162sleep (GO:0030431)2.51049804
163regulation of macrophage chemotaxis (GO:0010758)2.50707895
164RNA methylation (GO:0001510)2.50274466
165histone H3 acetylation (GO:0043966)2.49520341
166learning (GO:0007612)2.47870775
167regulation of neurotransmitter transport (GO:0051588)2.47731844
168neuromuscular process (GO:0050905)2.47074307
169membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46975759
170cytoskeletal anchoring at plasma membrane (GO:0007016)2.46864197
171histone H4 acetylation (GO:0043967)2.46037614
172acidic amino acid transport (GO:0015800)2.45346596
173negative regulation of neurotransmitter transport (GO:0051589)2.44785925
174positive regulation of mitotic cell cycle phase transition (GO:1901992)2.44521291
175cellular sodium ion homeostasis (GO:0006883)2.44456504
176membrane depolarization (GO:0051899)2.43299489
177regulation of synaptic transmission (GO:0050804)2.42985679
178regulation of T-helper 2 cell differentiation (GO:0045628)2.42863539
179negative regulation of amino acid transport (GO:0051956)2.42717802
180behavioral response to nicotine (GO:0035095)2.41264363
181protein palmitoylation (GO:0018345)2.39159122
182histone H4-K12 acetylation (GO:0043983)10.2044627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01505842
2JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86876265
3* RARB_27405468_Chip-Seq_BRAIN_Mouse2.74751982
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.73403896
5LXR_22292898_ChIP-Seq_THP-1_Human2.70752346
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69250928
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.67239863
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.65865912
9DROSHA_22980978_ChIP-Seq_HELA_Human2.56121624
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54184160
11VDR_21846776_ChIP-Seq_THP-1_Human2.49272913
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45527279
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45527279
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.40639369
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.39033539
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37459602
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.32227482
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32068676
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26867316
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.25856004
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20068960
22GBX2_23144817_ChIP-Seq_PC3_Human2.19794162
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17480348
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17286627
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.16586279
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16445989
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.13466580
28* REST_18959480_ChIP-ChIP_MESCs_Mouse2.10729947
29AR_21572438_ChIP-Seq_LNCaP_Human2.08764859
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04832339
31MYC_22102868_ChIP-Seq_BL_Human2.03382707
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99862842
33RACK7_27058665_Chip-Seq_MCF-7_Human1.96958142
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91933972
35SMC4_20622854_ChIP-Seq_HELA_Human1.90496200
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87394207
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.86765209
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85268237
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85268237
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85268237
41CREB1_26743006_Chip-Seq_LNCaP_Human1.81783055
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80306451
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.76089632
44P68_20966046_ChIP-Seq_HELA_Human1.69871198
45KDM2B_26808549_Chip-Seq_K562_Human1.69863777
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.67432553
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.67327519
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66191835
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.63922345
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60945807
51VDR_24763502_ChIP-Seq_THP-1_Human1.60267738
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55277724
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.50884702
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.49310397
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48452665
56MAF_26560356_Chip-Seq_TH1_Human1.48057177
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.47332241
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.44979338
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44503436
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.43371830
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43118407
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.42254316
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42205141
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39471172
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.38378204
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38212722
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36842670
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34204923
69* RING1B_27294783_Chip-Seq_NPCs_Mouse1.31506415
70KDM2B_26808549_Chip-Seq_DND41_Human1.29470872
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.28845441
72ZNF263_19887448_ChIP-Seq_K562_Human1.27735599
73BCOR_27268052_Chip-Seq_Bcells_Human1.27183437
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.26964014
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26907202
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26150826
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26150826
78GATA1_19941826_ChIP-Seq_K562_Human1.25294435
79* RARB_24833708_ChIP-Seq_LIVER_Mouse1.24032909
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23770935
81UTX_26944678_Chip-Seq_JUKART_Human1.23582168
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22465997
83* BCL6_27268052_Chip-Seq_Bcells_Human1.21302767
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20628613
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20311732
86MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19870416
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17701195
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17375625
89TP53_16413492_ChIP-PET_HCT116_Human1.17084659
90LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17023603
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16630975
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15831797
93SA1_27219007_Chip-Seq_Bcells_Human1.15797436
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15477742
95* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15314879
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15268772
97TET1_21490601_ChIP-Seq_MESCs_Mouse1.14848586
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14765056
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14572063
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12308267
101STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10584134
102FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10415264
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10244458
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.10127335
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09688508
106STAT3_23295773_ChIP-Seq_U87_Human1.09550753
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08803486
108* ATF3_27146783_Chip-Seq_COLON_Human1.08309010
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.08115506
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07871542
111* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07654497
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07562508
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07039580
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06499829
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.06301610
116GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06140964
117AR_19668381_ChIP-Seq_PC3_Human1.05943420
118CTCF_21964334_Chip-Seq_Bcells_Human1.05840084
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05754139
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05295057
121TP63_22573176_ChIP-Seq_HFKS_Human1.04904491
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04644019
123CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04350718
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03920051
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03455699
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02961318
127RUNX1_22412390_ChIP-Seq_EML_Mouse1.01933346
128CBX2_27304074_Chip-Seq_ESCs_Mouse1.01565891
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99660710
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.99403781
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99394455
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.99342230
133ETS1_21867929_ChIP-Seq_TH2_Mouse0.99237566
134NCOR1_26117541_ChIP-Seq_K562_Human0.98893897
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97970344
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97783187
137* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97738906
138SMAD4_21799915_ChIP-Seq_A2780_Human0.97441735
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97432248
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97121574
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.97121269
142CTCF_20526341_ChIP-Seq_ESCs_Human0.96692671
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96418502
144CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96106823
145* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95046924
146CTCF_27219007_Chip-Seq_Bcells_Human0.94471492
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94052942
148RNF2_27304074_Chip-Seq_NSC_Mouse0.93765295
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93118025
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.92074933
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91828169
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.91783564
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91288114
154OCT4_19829295_ChIP-Seq_ESCs_Human0.90896811
155TCF4_23295773_ChIP-Seq_U87_Human0.90860274
156* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89690380
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88984711
158ESR2_21235772_ChIP-Seq_MCF-7_Human0.88041743
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85810926
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84418159
161SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83981963
162STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83798242
163KLF4_19829295_ChIP-Seq_ESCs_Human0.83043667
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.82808247
165AR_25329375_ChIP-Seq_VCAP_Human0.82584668
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80869583
167RXR_22108803_ChIP-Seq_LS180_Human0.80579310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.39148192
2MP0003880_abnormal_central_pattern4.15260798
3MP0004185_abnormal_adipocyte_glucose3.58312363
4MP0003635_abnormal_synaptic_transmissio3.53504850
5MP0006082_CNS_inflammation3.32745600
6MP0004270_analgesia3.19920648
7MP0009046_muscle_twitch3.06848971
8MP0005423_abnormal_somatic_nervous3.01538225
9MP0002064_seizures2.93377519
10MP0003183_abnormal_peptide_metabolism2.82531907
11MP0009745_abnormal_behavioral_response2.82058502
12MP0002063_abnormal_learning/memory/cond2.69379881
13MP0001486_abnormal_startle_reflex2.48972759
14MP0002272_abnormal_nervous_system2.38113992
15MP0000920_abnormal_myelination2.32801001
16MP0001348_abnormal_lacrimal_gland2.30002178
17MP0009333_abnormal_splenocyte_physiolog2.26618310
18MP0002572_abnormal_emotion/affect_behav2.25066658
19MP0000750_abnormal_muscle_regeneration2.23556464
20MP0000778_abnormal_nervous_system2.19839956
21MP0004885_abnormal_endolymph2.17905032
22MP0003329_amyloid_beta_deposits2.17575293
23MP0004742_abnormal_vestibular_system2.12958106
24MP0000685_abnormal_immune_system2.11825550
25MP0008569_lethality_at_weaning2.11767098
26MP0003436_decreased_susceptibility_to2.11065774
27MP0002734_abnormal_mechanical_nocicepti2.10145350
28MP0005166_decreased_susceptibility_to2.09767499
29MP0002138_abnormal_hepatobiliary_system2.07943121
30MP0001440_abnormal_grooming_behavior2.00633277
31MP0001968_abnormal_touch/_nociception1.99064501
32MP0005666_abnormal_adipose_tissue1.86314133
33MP0005671_abnormal_response_to1.83048126
34MP0002067_abnormal_sensory_capabilities1.80280505
35MP0002735_abnormal_chemical_nociception1.78698975
36MP0001915_intracranial_hemorrhage1.75166072
37MP0002736_abnormal_nociception_after1.68947370
38MP0001501_abnormal_sleep_pattern1.68387842
39MP0003690_abnormal_glial_cell1.63425496
40MP0000955_abnormal_spinal_cord1.62638975
41MP0004858_abnormal_nervous_system1.61757328
42MP0005076_abnormal_cell_differentiation1.57840981
43MP0002184_abnormal_innervation1.57070343
44MP0005409_darkened_coat_color1.56534223
45MP0001970_abnormal_pain_threshold1.55767109
46MP0002653_abnormal_ependyma_morphology1.54618874
47MP0002733_abnormal_thermal_nociception1.54437712
48MP0004510_myositis1.49406645
49MP0002066_abnormal_motor_capabilities/c1.45700086
50MP0004811_abnormal_neuron_physiology1.44901339
51MP0004142_abnormal_muscle_tone1.44647422
52MP0002102_abnormal_ear_morphology1.44389531
53MP0000678_abnormal_parathyroid_gland1.43280503
54MP0002882_abnormal_neuron_morphology1.41834537
55MP0008260_abnormal_autophagy1.37441439
56MP0003634_abnormal_glial_cell1.31333517
57MP0001849_ear_inflammation1.30361206
58MP0003632_abnormal_nervous_system1.30164490
59MP0009780_abnormal_chondrocyte_physiolo1.22473239
60MP0005623_abnormal_meninges_morphology1.22226681
61MP0001529_abnormal_vocalization1.21775955
62MP0002152_abnormal_brain_morphology1.21726015
63MP0001905_abnormal_dopamine_level1.20308728
64MP0002557_abnormal_social/conspecific_i1.18967993
65MP0003879_abnormal_hair_cell1.18873797
66MP0005310_abnormal_salivary_gland1.18554421
67MP0004924_abnormal_behavior1.18396499
68MP0005386_behavior/neurological_phenoty1.18396499
69MP0003123_paternal_imprinting1.15860117
70MP0004019_abnormal_vitamin_homeostasis1.15593023
71MP0005375_adipose_tissue_phenotype1.13127322
72MP0000383_abnormal_hair_follicle1.12369048
73MP0008961_abnormal_basal_metabolism1.10651497
74MP0004883_abnormal_blood_vessel1.10133350
75MP0002229_neurodegeneration1.10096762
76MP0005058_abnormal_lysosome_morphology1.09943265
77MP0003631_nervous_system_phenotype1.08771442
78MP0002089_abnormal_postnatal_growth/wei1.08391260
79MP0000462_abnormal_digestive_system1.05960416
80MP0002249_abnormal_larynx_morphology1.03467004
81MP0003567_abnormal_fetal_cardiomyocyte1.01827454
82MP0005025_abnormal_response_to1.01097772
83MP0003453_abnormal_keratinocyte_physiol0.99679295
84MP0005551_abnormal_eye_electrophysiolog0.98091923
85MP0001485_abnormal_pinna_reflex0.97555802
86MP0005670_abnormal_white_adipose0.97295817
87MP0010678_abnormal_skin_adnexa0.97192861
88MP0000604_amyloidosis0.95713519
89MP0001243_abnormal_dermal_layer0.93408749
90MP0001963_abnormal_hearing_physiology0.93344670
91MP0004147_increased_porphyrin_level0.93093640
92MP0003938_abnormal_ear_development0.93089476
93MP0009785_altered_susceptibility_to0.92497280
94MP0005000_abnormal_immune_tolerance0.91464439
95MP0009840_abnormal_foam_cell0.91416017
96MP0003861_abnormal_nervous_system0.91031658
97MP0002752_abnormal_somatic_nervous0.90941688
98MP0001502_abnormal_circadian_rhythm0.90074654
99MP0003633_abnormal_nervous_system0.89000103
100MP0005451_abnormal_body_composition0.88651037
101MP0010234_abnormal_vibrissa_follicle0.86831455
102MP0001188_hyperpigmentation0.86061046
103MP0003303_peritoneal_inflammation0.85552870
104MP0002419_abnormal_innate_immunity0.85528152
105MP0005171_absent_coat_pigmentation0.85302442
106MP0003699_abnormal_female_reproductive0.85186544
107MP0009278_abnormal_bone_marrow0.85079481
108MP0004233_abnormal_muscle_weight0.83367485
109MP0003787_abnormal_imprinting0.81187875
110MP0002998_abnormal_bone_remodeling0.80880494
111MP0004947_skin_inflammation0.80670141
112MP0005377_hearing/vestibular/ear_phenot0.79157912
113MP0003878_abnormal_ear_physiology0.79157912
114MP0008874_decreased_physiological_sensi0.77688548
115MP0004145_abnormal_muscle_electrophysio0.77579988
116MP0003705_abnormal_hypodermis_morpholog0.77468861
117MP0001299_abnormal_eye_distance/0.74594593
118MP0002796_impaired_skin_barrier0.74474204
119MP0008877_abnormal_DNA_methylation0.73275906
120MP0003075_altered_response_to0.73016025
121MP0003172_abnormal_lysosome_physiology0.72972385
122MP0002822_catalepsy0.71809425
123MP0001727_abnormal_embryo_implantation0.71126627
124MP0003718_maternal_effect0.70035442
125MP0004484_altered_response_of0.69230145
126MP0000015_abnormal_ear_pigmentation0.68418366
127MP0001929_abnormal_gametogenesis0.67847477
128MP0005410_abnormal_fertilization0.67061790
129MP0001731_abnormal_postnatal_growth0.64978521
130MP0002161_abnormal_fertility/fecundity0.64188229
131MP0001851_eye_inflammation0.62936979
132MP0003698_abnormal_male_reproductive0.62273921
133MP0010769_abnormal_survival0.62168746
134MP0001765_abnormal_ion_homeostasis0.61684547
135MP0000747_muscle_weakness0.61012512
136MP0003136_yellow_coat_color0.60360835
137MP0010768_mortality/aging0.60302605
138MP0002069_abnormal_eating/drinking_beha0.59478264
139MP0004043_abnormal_pH_regulation0.58966798
140MP0000026_abnormal_inner_ear0.58914310
141MP0001346_abnormal_lacrimal_gland0.58561292
142MP0000759_abnormal_skeletal_muscle0.57800763
143MP0004381_abnormal_hair_follicle0.57673211
144MP0005621_abnormal_cell_physiology0.57478530
145MP0002148_abnormal_hypersensitivity_rea0.57177940
146MP0002163_abnormal_gland_morphology0.56560388
147MP0004130_abnormal_muscle_cell0.56304499
148MP0003045_fibrosis0.55981914
149MP0005083_abnormal_biliary_tract0.55211243
150MP0002082_postnatal_lethality0.54916424
151MP0010770_preweaning_lethality0.54916424
152MP0005394_taste/olfaction_phenotype0.54243995
153MP0005499_abnormal_olfactory_system0.54243995
154MP0000703_abnormal_thymus_morphology0.53841341
155MP0008873_increased_physiological_sensi0.53511395
156MP0003866_abnormal_defecation0.52049509
157MP0002269_muscular_atrophy0.51318603

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.27260331
2Focal motor seizures (HP:0011153)5.09311822
3Severe visual impairment (HP:0001141)4.84428641
4Atonic seizures (HP:0010819)4.31789496
5Progressive cerebellar ataxia (HP:0002073)4.20041864
6Focal seizures (HP:0007359)4.04700102
7Supranuclear gaze palsy (HP:0000605)3.85864923
8Cortical dysplasia (HP:0002539)3.82926005
9Ankle clonus (HP:0011448)3.76335930
10Peripheral hypomyelination (HP:0007182)3.64214627
11Epileptic encephalopathy (HP:0200134)3.55074121
12Achilles tendon contracture (HP:0001771)3.50597504
13Gaze-evoked nystagmus (HP:0000640)3.44072607
14Genetic anticipation (HP:0003743)3.40151555
15Dysmetria (HP:0001310)3.39672646
16Neurofibrillary tangles (HP:0002185)3.39222751
17Sparse lateral eyebrow (HP:0005338)3.33828965
18Visual hallucinations (HP:0002367)3.29764553
19Curly hair (HP:0002212)3.28055029
20Action tremor (HP:0002345)3.24450251
21Scotoma (HP:0000575)3.24041973
22Abnormality of the Achilles tendon (HP:0005109)3.19806960
23Febrile seizures (HP:0002373)3.17429528
24Long palpebral fissure (HP:0000637)3.16217199
25Dialeptic seizures (HP:0011146)3.13055187
26Absence seizures (HP:0002121)3.02488169
27Syringomyelia (HP:0003396)3.02370422
28Spinal cord lesions (HP:0100561)3.02370422
29Hyperlipoproteinemia (HP:0010980)3.01824149
30Slow saccadic eye movements (HP:0000514)2.93408940
31Truncal ataxia (HP:0002078)2.90420302
32Cerebral inclusion bodies (HP:0100314)2.89228112
33Impulsivity (HP:0100710)2.88632177
34Sensory axonal neuropathy (HP:0003390)2.84515372
35Spastic gait (HP:0002064)2.82329942
36Mutism (HP:0002300)2.79870914
37Cerebral hypomyelination (HP:0006808)2.76296296
38Abnormality of the corticospinal tract (HP:0002492)2.75345560
39Progressive inability to walk (HP:0002505)2.73540251
40Broad-based gait (HP:0002136)2.72736847
41Urinary bladder sphincter dysfunction (HP:0002839)2.71888954
42Dysmetric saccades (HP:0000641)2.70795656
43Abnormality of the fingertips (HP:0001211)2.66600265
44Hypercortisolism (HP:0001578)2.62574445
45Dysdiadochokinesis (HP:0002075)2.59702664
46Megalencephaly (HP:0001355)2.57241081
47Asymmetry of the thorax (HP:0001555)2.55735912
48Submucous cleft hard palate (HP:0000176)2.52896454
49Easy fatigability (HP:0003388)2.49815066
50Intention tremor (HP:0002080)2.49596723
51Underdeveloped supraorbital ridges (HP:0009891)2.48475229
52Onion bulb formation (HP:0003383)2.47363869
53Hemiparesis (HP:0001269)2.46605435
54Oligodactyly (hands) (HP:0001180)2.43539315
55Scanning speech (HP:0002168)2.39347118
56Abnormality of binocular vision (HP:0011514)2.39334735
57Diplopia (HP:0000651)2.39334735
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.39261314
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39261314
60Akinesia (HP:0002304)2.38800412
61Thickened helices (HP:0000391)2.38262046
62Spastic tetraparesis (HP:0001285)2.37555268
63Deep philtrum (HP:0002002)2.32860786
64Epidermoid cyst (HP:0200040)2.30386407
65Acute myeloid leukemia (HP:0004808)2.30031033
66Annular pancreas (HP:0001734)2.29915517
67Xanthomatosis (HP:0000991)2.28940560
68Urinary urgency (HP:0000012)2.28325777
69Hemiplegia (HP:0002301)2.27744209
70Exercise-induced myalgia (HP:0003738)2.27134674
71Overriding aorta (HP:0002623)2.26289850
72Relative macrocephaly (HP:0004482)2.26229591
73Generalized tonic-clonic seizures (HP:0002069)2.25458523
74Skin nodule (HP:0200036)2.24977803
75Hypercholesterolemia (HP:0003124)2.24352980
76Fetal akinesia sequence (HP:0001989)2.21854578
77Abnormal gallbladder physiology (HP:0012438)2.20873980
78Cholecystitis (HP:0001082)2.20873980
79Postural instability (HP:0002172)2.20629528
80Aqueductal stenosis (HP:0002410)2.20533651
81Absent speech (HP:0001344)2.18754288
82Abnormality of the phalanges of the hallux (HP:0010057)2.15314418
83Abnormality of saccadic eye movements (HP:0000570)2.15048135
84Obstructive sleep apnea (HP:0002870)2.14802121
85Impaired smooth pursuit (HP:0007772)2.14476688
86Stereotypic behavior (HP:0000733)2.14191942
87Hypertriglyceridemia (HP:0002155)2.13123638
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11533425
89Insomnia (HP:0100785)2.10110315
90Menstrual irregularities (HP:0000858)2.07673485
91Tetraplegia (HP:0002445)2.07578897
92Central scotoma (HP:0000603)2.07479087
93Abnormality of small intestinal villus morphology (HP:0011472)2.03492132
94Villous atrophy (HP:0011473)2.03492132
95Bundle branch block (HP:0011710)2.02686072
96Hyperparathyroidism (HP:0000843)2.01476861
97Cystic hygroma (HP:0000476)1.97975371
98Drooling (HP:0002307)1.97647500
99Excessive salivation (HP:0003781)1.97647500
100Glossoptosis (HP:0000162)1.96884027
101Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96333973
102Apathy (HP:0000741)1.96261000
103Hypoparathyroidism (HP:0000829)1.96161001
104Deep palmar crease (HP:0006191)1.96026972
105Hyporeflexia of lower limbs (HP:0002600)1.94745125
106Split foot (HP:0001839)1.93015526
107Male infertility (HP:0003251)1.92235207
108Abnormality of ocular smooth pursuit (HP:0000617)1.91909359
109Short chin (HP:0000331)1.91694215
110Abnormality of the periventricular white matter (HP:0002518)1.88764693
111Pointed chin (HP:0000307)1.88700290
112Muscle stiffness (HP:0003552)1.88578144
113Distal lower limb muscle weakness (HP:0009053)1.88396702
114Bowel incontinence (HP:0002607)1.87636107
115Choroideremia (HP:0001139)1.87458339
116Spinal canal stenosis (HP:0003416)1.87126570
117Abnormal eating behavior (HP:0100738)1.86914760
118Truncus arteriosus (HP:0001660)1.86778795
119Progressive microcephaly (HP:0000253)1.86679750
120Anteriorly placed anus (HP:0001545)1.85865969
121Growth hormone excess (HP:0000845)1.85140567
122Inability to walk (HP:0002540)1.84654382
123Lower limb muscle weakness (HP:0007340)1.84619427
124Flared iliac wings (HP:0002869)1.82849807
125Abnormality of glycolipid metabolism (HP:0010969)1.82615774
126Abnormality of liposaccharide metabolism (HP:0010968)1.82615774
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.82615774
128Heterotopia (HP:0002282)1.82264059
129Abnormal large intestine physiology (HP:0012700)1.81597070
130Ventricular fibrillation (HP:0001663)1.80789855
131Generalized hyperpigmentation (HP:0007440)1.79996962
132Absent eyebrow (HP:0002223)1.78264955
133Absent septum pellucidum (HP:0001331)1.78190633
134Morphological abnormality of the pyramidal tract (HP:0002062)1.75756271
135Amblyopia (HP:0000646)1.75621268
136Delusions (HP:0000746)1.75401260
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75214865
138CNS hypomyelination (HP:0003429)1.74956375
139Rigidity (HP:0002063)1.74914029
140Generalized myoclonic seizures (HP:0002123)1.74823174
141Polygenic inheritance (HP:0010982)1.74655454
142Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74036741
143Distal upper limb amyotrophy (HP:0007149)1.73939401
144Upper limb amyotrophy (HP:0009129)1.73939401
145Bulbar palsy (HP:0001283)1.73924888
146Esophageal atresia (HP:0002032)1.73908693
147Hyperthyroidism (HP:0000836)1.72731823
148Impaired vibration sensation in the lower limbs (HP:0002166)1.72528289
149Complete atrioventricular canal defect (HP:0001674)1.71916980
150Broad face (HP:0000283)1.71598557
151Retinal dysplasia (HP:0007973)1.71301268
152Nonprogressive disorder (HP:0003680)1.70448287
153Reticulocytosis (HP:0001923)1.70069819
154Diminished motivation (HP:0000745)1.69543203
155Vertebral compression fractures (HP:0002953)1.68666480
156Absent eyelashes (HP:0000561)1.68241965
157Clonus (HP:0002169)1.67562239
158Septo-optic dysplasia (HP:0100842)1.63359791
159Widely spaced teeth (HP:0000687)1.61887255
160Neuronal loss in central nervous system (HP:0002529)1.58995673
161Depression (HP:0000716)1.58931451
162Oligodactyly (HP:0012165)1.57750523
163Amyotrophic lateral sclerosis (HP:0007354)1.57709900
164Lower limb amyotrophy (HP:0007210)1.57476773
165Hyperacusis (HP:0010780)1.56517359
166Stomatitis (HP:0010280)1.55755418
167Segmental peripheral demyelination/remyelination (HP:0003481)1.55717936
168Chin dimple (HP:0010751)1.54374427
169Clumsiness (HP:0002312)1.54043571
170Congenital stationary night blindness (HP:0007642)1.52500638
171Anosmia (HP:0000458)1.52312618
172Poor eye contact (HP:0000817)1.50421409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK45.82452401
2AKT35.70440266
3MAP3K94.24384508
4TAF14.03290937
5CDK193.30838204
6EPHA43.23324465
7BRAF3.05767646
8PAK62.81867122
9ERN12.70388966
10NTRK32.52878194
11STK392.47819548
12RIPK12.46104885
13TYRO32.42591647
14MARK12.30584457
15MAP3K132.18821811
16RIPK42.16291515
17OXSR12.14547463
18PRPF4B2.09883207
19PTK22.08030252
20ILK2.04320539
21KSR21.99711355
22MARK31.99156519
23ICK1.90118206
24NTRK21.88553086
25TRIB31.83889682
26MINK11.78104594
27TNIK1.74691753
28DAPK21.68686577
29SIK11.66067931
30PRKD31.63651822
31MAP3K111.59553324
32LATS21.52692434
33SGK21.45425116
34KSR11.43953659
35MAP2K31.38353151
36TAOK11.38280879
37CDK51.38187250
38FES1.36288144
39FGFR21.32653331
40NEK61.26976894
41TAOK21.25232462
42EPHB11.25216905
43MAP3K41.19251665
44STK111.18105726
45MARK21.17576547
46NTRK11.17456200
47BCR1.16272237
48ALK1.14686432
49FGR1.12420904
50HIPK21.11360642
51CDK151.08262062
52WNK11.07614017
53RAF11.06654892
54PNCK1.06464052
55SMG11.05827761
56CDK181.04686183
57CDK11A1.04455013
58PIK3CG1.01837763
59STK381.00954326
60IRAK31.00221753
61PRKCI0.99252073
62UHMK10.98935592
63DMPK0.98889871
64CDK140.97729527
65BMX0.97565221
66PDK10.95539781
67MAP2K70.93949014
68PDPK10.92950834
69PKN10.91881870
70EPHA20.90613908
71MAPKAPK30.90270889
72SIK20.90213604
73PLK20.89742433
74ROCK20.89697907
75CAMKK10.89337695
76PRKD20.89045998
77MUSK0.88843632
78PRKCH0.86491736
79SGK4940.86275076
80SGK2230.86275076
81MAPK130.85778991
82CLK10.82841264
83MAP4K10.82796413
84DYRK1A0.79381263
85TESK10.77589110
86LRRK20.77516798
87CAMK2B0.74763397
88MAP3K100.72878687
89ARAF0.71057339
90FGFR40.70140686
91CSNK1G20.69242650
92CDK120.67553863
93IRAK20.67033741
94MAPK100.66073207
95CCNB10.65647786
96BRD40.65499073
97PIM10.65171510
98CAMK2A0.64838516
99MOS0.64214274
100TNK20.64187716
101PRKCG0.61924653
102MAP3K30.59893933
103FYN0.58362149
104MAPKAPK50.58261520
105GRK50.58206948
106LMTK20.56833235
107MAP3K70.55651280
108SGK10.54408535
109SCYL20.54256335
110CAMK40.53239736
111PAK30.53087173
112AURKA0.52912106
113PRKCZ0.51857902
114DYRK20.51720448
115CDK90.49590567
116PDGFRB0.48466821
117GRK60.47921296
118PAK10.47578214
119MTOR0.47216683
120ABL20.45526048
121EEF2K0.45255933
122HCK0.45244401
123CHEK10.45165547
124PRKCQ0.43844822
125CAMK2G0.43303887
126MAP3K10.43266886
127DAPK10.42553093
128CAMK10.40679749
129MAPK80.40528642
130CSNK1A1L0.39985383
131RET0.38947411
132MAP2K60.38387120
133GSK3B0.36996553
134RPS6KA30.36962233
135TXK0.36691176
136RPS6KB20.35893079
137MAP3K80.35598920
138CAMK2D0.35562651
139SIK30.34208782
140RPS6KA20.33226993
141BRSK10.32331168
142MAP2K10.31723300
143MAPK70.31130813
144CAMK1G0.30509136
145SGK30.30495160
146MAPK120.30466938
147TESK20.30147470
148CSNK1A10.29912348
149MAP3K20.25262471
150PRKG20.24567714
151CDK70.24371313

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.90852679
2Glutamatergic synapse_Homo sapiens_hsa047242.21976385
3Synaptic vesicle cycle_Homo sapiens_hsa047212.19841961
4Fatty acid elongation_Homo sapiens_hsa000622.19360704
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15704639
6Morphine addiction_Homo sapiens_hsa050322.07522117
7Long-term potentiation_Homo sapiens_hsa047202.06468140
8GABAergic synapse_Homo sapiens_hsa047272.00056185
9Thyroid cancer_Homo sapiens_hsa052161.99043713
10Circadian entrainment_Homo sapiens_hsa047131.93848369
11Salivary secretion_Homo sapiens_hsa049701.83153436
12Gastric acid secretion_Homo sapiens_hsa049711.77626435
13Olfactory transduction_Homo sapiens_hsa047401.66780600
14Acute myeloid leukemia_Homo sapiens_hsa052211.66596138
15Long-term depression_Homo sapiens_hsa047301.66079749
16Sulfur relay system_Homo sapiens_hsa041221.55143410
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52079008
18Cholinergic synapse_Homo sapiens_hsa047251.51882943
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51801523
20Amphetamine addiction_Homo sapiens_hsa050311.48099688
21Dopaminergic synapse_Homo sapiens_hsa047281.41265399
22Dorso-ventral axis formation_Homo sapiens_hsa043201.40609733
23Oxytocin signaling pathway_Homo sapiens_hsa049211.37471856
24ErbB signaling pathway_Homo sapiens_hsa040121.35658340
25Vitamin B6 metabolism_Homo sapiens_hsa007501.31566643
26GnRH signaling pathway_Homo sapiens_hsa049121.30372823
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29779098
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29345309
29Axon guidance_Homo sapiens_hsa043601.27145716
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.25605065
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21239102
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20856339
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19728265
34Serotonergic synapse_Homo sapiens_hsa047261.17983928
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17795582
36Gap junction_Homo sapiens_hsa045401.17091368
37Insulin signaling pathway_Homo sapiens_hsa049101.16416110
38Renal cell carcinoma_Homo sapiens_hsa052111.15735968
39Choline metabolism in cancer_Homo sapiens_hsa052311.11383783
40Notch signaling pathway_Homo sapiens_hsa043301.10508108
41Bladder cancer_Homo sapiens_hsa052191.10127417
42cAMP signaling pathway_Homo sapiens_hsa040241.09651017
43Insulin secretion_Homo sapiens_hsa049111.09201736
44Glioma_Homo sapiens_hsa052141.08952206
45Renin secretion_Homo sapiens_hsa049241.07841960
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07171667
47Sphingolipid signaling pathway_Homo sapiens_hsa040711.06430931
48Oocyte meiosis_Homo sapiens_hsa041141.06052326
49Calcium signaling pathway_Homo sapiens_hsa040201.03473528
50Hepatitis C_Homo sapiens_hsa051601.01872739
51Taste transduction_Homo sapiens_hsa047421.00208732
52Type II diabetes mellitus_Homo sapiens_hsa049300.99552412
53Inositol phosphate metabolism_Homo sapiens_hsa005620.98744368
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97962846
55T cell receptor signaling pathway_Homo sapiens_hsa046600.97752361
56MAPK signaling pathway_Homo sapiens_hsa040100.97005102
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96839512
58VEGF signaling pathway_Homo sapiens_hsa043700.96691359
59Prolactin signaling pathway_Homo sapiens_hsa049170.94878640
60Estrogen signaling pathway_Homo sapiens_hsa049150.94850493
61Cocaine addiction_Homo sapiens_hsa050300.93622818
62Leishmaniasis_Homo sapiens_hsa051400.93207255
63Collecting duct acid secretion_Homo sapiens_hsa049660.91926368
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91610172
65FoxO signaling pathway_Homo sapiens_hsa040680.90993215
66Chemokine signaling pathway_Homo sapiens_hsa040620.90205964
67Melanogenesis_Homo sapiens_hsa049160.89221999
68Pancreatic cancer_Homo sapiens_hsa052120.88829498
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.87876525
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87322010
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84787919
72Prion diseases_Homo sapiens_hsa050200.83747082
73AMPK signaling pathway_Homo sapiens_hsa041520.83421824
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82223360
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82213888
76Endocytosis_Homo sapiens_hsa041440.81811928
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77834314
78Prostate cancer_Homo sapiens_hsa052150.77298392
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76901279
80Sphingolipid metabolism_Homo sapiens_hsa006000.76721443
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.75084612
82mTOR signaling pathway_Homo sapiens_hsa041500.73658124
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72763721
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72673513
85Phototransduction_Homo sapiens_hsa047440.72567770
86Mineral absorption_Homo sapiens_hsa049780.72056964
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71770699
88Pancreatic secretion_Homo sapiens_hsa049720.71574816
89B cell receptor signaling pathway_Homo sapiens_hsa046620.71072241
90Influenza A_Homo sapiens_hsa051640.70122580
91Ras signaling pathway_Homo sapiens_hsa040140.69409667
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.68482540
93TNF signaling pathway_Homo sapiens_hsa046680.67397468
94Rheumatoid arthritis_Homo sapiens_hsa053230.66873637
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66774921
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.65222196
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63801579
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63221750
99Toxoplasmosis_Homo sapiens_hsa051450.62808898
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62707295
101Pertussis_Homo sapiens_hsa051330.61836366
102Circadian rhythm_Homo sapiens_hsa047100.61778677
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61640420
104Apoptosis_Homo sapiens_hsa042100.60926873
105Rap1 signaling pathway_Homo sapiens_hsa040150.60734372
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60073185
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59649309
108Hepatitis B_Homo sapiens_hsa051610.59137307
109Ether lipid metabolism_Homo sapiens_hsa005650.58783940
110Non-small cell lung cancer_Homo sapiens_hsa052230.58533271
111Regulation of autophagy_Homo sapiens_hsa041400.56903495
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56697585
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.56557173
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56363928
115Wnt signaling pathway_Homo sapiens_hsa043100.55788524
116Bile secretion_Homo sapiens_hsa049760.55254755
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55049386
118Shigellosis_Homo sapiens_hsa051310.53678259
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53093137
120Osteoclast differentiation_Homo sapiens_hsa043800.52095875
121Colorectal cancer_Homo sapiens_hsa052100.52030405
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49752724
123Tuberculosis_Homo sapiens_hsa051520.49611616
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49489333
125Salmonella infection_Homo sapiens_hsa051320.48768573
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48319797
127Vibrio cholerae infection_Homo sapiens_hsa051100.47471106
128Chronic myeloid leukemia_Homo sapiens_hsa052200.46778024
129Endometrial cancer_Homo sapiens_hsa052130.45623708
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45206665

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