SPARC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.86293366
2protein heterotrimerization (GO:0070208)6.82032163
3chondrocyte proliferation (GO:0035988)5.28077365
4bone trabecula formation (GO:0060346)5.12736498
5cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.97686110
6collagen metabolic process (GO:0032963)4.86203137
7collagen catabolic process (GO:0030574)4.80541802
8keratan sulfate catabolic process (GO:0042340)4.65154185
9multicellular organismal macromolecule metabolic process (GO:0044259)4.58819778
10endodermal cell differentiation (GO:0035987)4.54820908
11basement membrane organization (GO:0071711)4.50741882
12skin morphogenesis (GO:0043589)4.43143359
13multicellular organismal catabolic process (GO:0044243)4.41947027
14multicellular organismal metabolic process (GO:0044236)4.32832188
15retina vasculature morphogenesis in camera-type eye (GO:0061299)4.30879699
16sequestering of extracellular ligand from receptor (GO:0035581)4.27195731
17extracellular fibril organization (GO:0043206)4.26539656
18chondrocyte development (GO:0002063)4.21675373
19extracellular matrix disassembly (GO:0022617)4.12812479
20endothelial cell morphogenesis (GO:0001886)4.06496156
21dermatan sulfate biosynthetic process (GO:0030208)3.98622551
22vascular endothelial growth factor signaling pathway (GO:0038084)3.90927612
23glomerular basement membrane development (GO:0032836)3.88717220
24peptidyl-proline hydroxylation (GO:0019511)3.88320232
25fibril organization (GO:0097435)3.84455777
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.69894622
27cell adhesion mediated by integrin (GO:0033627)3.69874343
28axon extension involved in axon guidance (GO:0048846)3.67138848
29neuron projection extension involved in neuron projection guidance (GO:1902284)3.67138848
30dermatan sulfate metabolic process (GO:0030205)3.62096665
31positive regulation of endothelial cell apoptotic process (GO:2000353)3.54905430
32protein retention in ER lumen (GO:0006621)3.51847924
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.46676365
34lymph vessel development (GO:0001945)3.42045977
35negative regulation of chondrocyte differentiation (GO:0032331)3.40221469
36protein hydroxylation (GO:0018126)3.39060025
37* extracellular matrix organization (GO:0030198)3.38323002
38wound healing, spreading of epidermal cells (GO:0035313)3.38009348
39blood vessel maturation (GO:0001955)3.37474669
40* extracellular structure organization (GO:0043062)3.37196615
41peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.36962090
42adhesion of symbiont to host cell (GO:0044650)3.25841891
43virion attachment to host cell (GO:0019062)3.25841891
44adhesion of symbiont to host (GO:0044406)3.22838023
45positive regulation of epithelial to mesenchymal transition (GO:0010718)3.19835233
46apoptotic cell clearance (GO:0043277)3.18773748
47positive regulation of extracellular matrix organization (GO:1903055)3.18671972
48lymphangiogenesis (GO:0001946)3.16430978
49cartilage condensation (GO:0001502)3.15333813
50cell aggregation (GO:0098743)3.15333813
51negative regulation of cartilage development (GO:0061037)3.13580850
52endochondral ossification (GO:0001958)3.11103212
53replacement ossification (GO:0036075)3.11103212
54extracellular matrix assembly (GO:0085029)3.08343487
55negative regulation of catenin import into nucleus (GO:0035414)3.05038913
56cellular response to vitamin (GO:0071295)3.04601944
57substrate adhesion-dependent cell spreading (GO:0034446)3.03020795
58barbed-end actin filament capping (GO:0051016)3.01050321
59epithelial cell-cell adhesion (GO:0090136)3.00436743
60cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.99357008
61glomerular filtration (GO:0003094)2.99026916
62negative regulation of protein localization to cell surface (GO:2000009)2.98942149
63chondroitin sulfate biosynthetic process (GO:0030206)2.98057684
64stress fiber assembly (GO:0043149)2.96917796
65atrioventricular valve morphogenesis (GO:0003181)2.96489442
66positive regulation of cartilage development (GO:0061036)2.95417901
67negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.95286363
68craniofacial suture morphogenesis (GO:0097094)2.94806908
69regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93774653
70metanephric mesenchyme development (GO:0072075)2.93339894
71renal filtration (GO:0097205)2.90643496
72chondroitin sulfate catabolic process (GO:0030207)2.89612883
73protein localization to cell surface (GO:0034394)2.88663804
74Golgi transport vesicle coating (GO:0048200)2.87009201
75COPI coating of Golgi vesicle (GO:0048205)2.87009201
76notochord development (GO:0030903)2.86481128
77regulation of axon extension involved in axon guidance (GO:0048841)2.81973899
78protein targeting to plasma membrane (GO:0072661)2.81523940
79negative regulation of fatty acid transport (GO:2000192)2.80379618
80endocardial cushion development (GO:0003197)2.80313050
81hippo signaling (GO:0035329)2.79857748
82regulation of integrin-mediated signaling pathway (GO:2001044)2.79603532
83positive regulation of blood vessel endothelial cell migration (GO:0043536)2.79398309
84regulation of cartilage development (GO:0061035)2.79009955
85cell migration involved in sprouting angiogenesis (GO:0002042)2.78680844
86trabecula formation (GO:0060343)2.78494500
87substrate-dependent cell migration (GO:0006929)2.78458510
88negative regulation of axon extension involved in axon guidance (GO:0048843)2.78287400
89cell migration involved in heart development (GO:0060973)2.77834344
90kidney mesenchyme development (GO:0072074)2.77023009
91endothelial cell proliferation (GO:0001935)2.76525177
92endothelium development (GO:0003158)2.74697686
93regulation of tight junction assembly (GO:2000810)2.72499536
94mesenchymal-epithelial cell signaling (GO:0060638)2.71518884
95cell-matrix adhesion (GO:0007160)2.70644376
96regulation of chondrocyte differentiation (GO:0032330)2.69518285
97positive regulation of axon extension (GO:0045773)2.69265250
98regulation of extracellular matrix disassembly (GO:0010715)2.66256278
99cell-substrate adhesion (GO:0031589)2.64423736
100negative regulation of smooth muscle cell migration (GO:0014912)2.64243365
101sprouting angiogenesis (GO:0002040)2.64173791
102regulation of SMAD protein import into nucleus (GO:0060390)2.63150057
103heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.61959541
104planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61759447
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61663887
106positive regulation of stem cell differentiation (GO:2000738)2.60808389
107venous blood vessel morphogenesis (GO:0048845)2.60605722
108plasma membrane repair (GO:0001778)2.60174400
109regulation of axon guidance (GO:1902667)2.59534022
110type B pancreatic cell proliferation (GO:0044342)2.58695217
111outer ear morphogenesis (GO:0042473)2.57895727
112negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.57895654
113glial cell migration (GO:0008347)2.57167992
114positive regulation of osteoblast proliferation (GO:0033690)2.56987966
115wound healing, spreading of cells (GO:0044319)2.56312306
116cell-substrate junction assembly (GO:0007044)2.55823353
117tooth mineralization (GO:0034505)2.55151245
118negative chemotaxis (GO:0050919)2.54947968
119muscle cell migration (GO:0014812)2.54680745
120vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54090087
121negative regulation of embryonic development (GO:0045992)2.51992206
122cochlea morphogenesis (GO:0090103)2.51719869
123Notch signaling involved in heart development (GO:0061314)2.51136716
124positive regulation of receptor recycling (GO:0001921)2.49246229
125cell proliferation involved in metanephros development (GO:0072203)2.49042156
126negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.48239532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.52662861
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.34013153
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.21946436
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.52256595
5CLOCK_20551151_ChIP-Seq_293T_Human3.18441799
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.64338911
7ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.54650726
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.48576405
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.36023851
10* CJUN_26792858_Chip-Seq_BT549_Human2.34318993
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.24301694
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20855224
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.18319830
14* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.12345821
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.11027765
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05555891
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.05452769
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.03233173
19* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97981385
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95747878
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.91020200
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.86413117
23BRD4_25478319_ChIP-Seq_HGPS_Human1.83047780
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.78908376
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69014023
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69014023
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64729936
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64729936
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64251134
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61872002
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61704026
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57893856
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.57657936
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57428322
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56772115
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56433157
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52164416
38* GATA2_21666600_ChIP-Seq_HMVEC_Human1.49429243
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.49296459
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46103415
41TP53_18474530_ChIP-ChIP_U2OS_Human1.42556284
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40976556
43GBX2_23144817_ChIP-Seq_PC3_Human1.40490145
44JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40311488
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38046658
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36382179
47* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.34410041
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.34351125
49SOX2_20726797_ChIP-Seq_SW620_Human1.34076640
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33652562
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32500620
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32500620
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32132476
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.30815230
55* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30337898
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.27848271
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.27848271
58AR_21572438_ChIP-Seq_LNCaP_Human1.26207898
59ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24275928
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22342805
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21793635
62UBF1/2_26484160_Chip-Seq_HMECs_Human1.21758792
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20336820
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20212890
65TP53_16413492_ChIP-PET_HCT116_Human1.19259144
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18356253
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.18180062
68* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17663860
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17624857
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17469492
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16849517
72* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16190091
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15344314
74KDM2B_26808549_Chip-Seq_K562_Human1.14510253
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14288425
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14061776
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12546885
78* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11758998
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.11582576
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.10782989
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10039326
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08688073
83TP53_23651856_ChIP-Seq_MEFs_Mouse1.08206140
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07687543
85SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04942327
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04033112
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.03524453
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03439177
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03206197
90TP53_22127205_ChIP-Seq_IMR90_Human1.02783512
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02658158
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02132656
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02107701
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01922068
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.00807329
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99986694
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99975916
98RACK7_27058665_Chip-Seq_MCF-7_Human0.99903999
99MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99576958
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.99178727
101* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98639951
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97697261
103SA1_22415368_ChIP-Seq_MEFs_Mouse0.97494896
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97395241
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97085567
106ATF3_27146783_Chip-Seq_COLON_Human0.95858833
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95844377
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94597334
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91911919
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91823644
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91576362
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.91153660
113JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90617798
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90072005
115EZH2_22144423_ChIP-Seq_EOC_Human0.89801597
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89503225
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89503225
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89503225
119SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89243728
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88633719
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86773553
122* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86338119
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85854039
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84295296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.80815974
2MP0005503_abnormal_tendon_morphology5.90855438
3MP0005275_abnormal_skin_tensile4.88807407
4MP0004272_abnormal_basement_membrane3.90649786
5MP0003705_abnormal_hypodermis_morpholog3.75177249
6MP0003279_aneurysm3.65478950
7MP0001958_emphysema3.14140541
8MP0006054_spinal_hemorrhage3.02308132
9MP0005623_abnormal_meninges_morphology2.94586917
10MP0009384_cardiac_valve_regurgitation2.80461436
11MP0010368_abnormal_lymphatic_system2.40594587
12* MP0005508_abnormal_skeleton_morphology2.28948735
13MP0001542_abnormal_bone_strength2.16248057
14MP0003566_abnormal_cell_adhesion2.03877430
15MP0004134_abnormal_chest_morphology1.97467194
16MP0009250_abnormal_appendicular_skeleto1.94751939
17MP0002108_abnormal_muscle_morphology1.91091598
18MP0000013_abnormal_adipose_tissue1.82822158
19MP0001879_abnormal_lymphatic_vessel1.80474205
20MP0002060_abnormal_skin_morphology1.75911653
21MP0002896_abnormal_bone_mineralization1.75280554
22MP0002295_abnormal_pulmonary_circulatio1.70014822
23MP0002933_joint_inflammation1.69666204
24MP0002282_abnormal_trachea_morphology1.64325826
25MP0005257_abnormal_intraocular_pressure1.60218186
26MP0000163_abnormal_cartilage_morphology1.59016524
27MP0003385_abnormal_body_wall1.54733638
28MP0003091_abnormal_cell_migration1.54491883
29MP0010030_abnormal_orbit_morphology1.47106964
30MP0002115_abnormal_skeleton_extremities1.46308349
31* MP0005023_abnormal_wound_healing1.44818967
32MP0000751_myopathy1.44435363
33MP0000767_abnormal_smooth_muscle1.42185413
34MP0003283_abnormal_digestive_organ1.37666795
35* MP0005390_skeleton_phenotype1.36881737
36MP0001299_abnormal_eye_distance/1.35670163
37MP0009780_abnormal_chondrocyte_physiolo1.33897819
38MP0003045_fibrosis1.26551309
39MP0002113_abnormal_skeleton_development1.22561625
40MP0001243_abnormal_dermal_layer1.19138090
41MP0002089_abnormal_postnatal_growth/wei1.17925189
42MP0000733_abnormal_muscle_development1.17904834
43MP0003942_abnormal_urinary_system1.12613847
44MP0002932_abnormal_joint_morphology1.11788120
45MP0000534_abnormal_ureter_morphology1.10792410
46MP0003941_abnormal_skin_development1.07902986
47MP0000003_abnormal_adipose_tissue1.06408985
48MP0004084_abnormal_cardiac_muscle1.05128708
49MP0002998_abnormal_bone_remodeling1.02791378
50MP0003115_abnormal_respiratory_system1.01200103
51MP0005164_abnormal_response_to1.00721412
52MP0005595_abnormal_vascular_smooth0.97239361
53MP0000516_abnormal_urinary_system0.95192426
54MP0005367_renal/urinary_system_phenotyp0.95192426
55MP0002168_other_aberrant_phenotype0.94924031
56MP0000049_abnormal_middle_ear0.93593859
57MP0002128_abnormal_blood_circulation0.93382340
58MP0009053_abnormal_anal_canal0.93227460
59MP0000762_abnormal_tongue_morphology0.92668365
60MP0002109_abnormal_limb_morphology0.92533214
61MP0003755_abnormal_palate_morphology0.89424862
62MP0000428_abnormal_craniofacial_morphol0.89207628
63* MP0001533_abnormal_skeleton_physiology0.88370935
64MP0010352_gastrointestinal_tract_polyps0.86803385
65MP0006138_congestive_heart_failure0.86204634
66MP0002116_abnormal_craniofacial_bone0.85572043
67MP0000462_abnormal_digestive_system0.85391438
68MP0001915_intracranial_hemorrhage0.85186990
69MP0001849_ear_inflammation0.85080379
70* MP0003795_abnormal_bone_structure0.84632719
71MP0001614_abnormal_blood_vessel0.83531813
72MP0005171_absent_coat_pigmentation0.82739042
73MP0000432_abnormal_head_morphology0.79372265
74MP0004883_abnormal_blood_vessel0.79094603
75MP0003935_abnormal_craniofacial_develop0.77831526
76MP0003828_pulmonary_edema0.76094227
77MP0005197_abnormal_uvea_morphology0.76092583
78MP0002249_abnormal_larynx_morphology0.76027256
79MP0004858_abnormal_nervous_system0.75694660
80MP0000750_abnormal_muscle_regeneration0.75691270
81MP0002925_abnormal_cardiovascular_devel0.74136245
82MP0000343_altered_response_to0.73984947
83MP0005620_abnormal_muscle_contractility0.70495589
84MP0005165_increased_susceptibility_to0.70165963
85MP0001175_abnormal_lung_morphology0.69477878
86MP0005388_respiratory_system_phenotype0.69003708
87MP0002133_abnormal_respiratory_system0.69003708
88MP0008775_abnormal_heart_ventricle0.68415050
89MP0005375_adipose_tissue_phenotype0.68344147
90MP0002111_abnormal_tail_morphology0.68259669
91MP0005076_abnormal_cell_differentiation0.68131266
92MP0002877_abnormal_melanocyte_morpholog0.67132214
93MP0010386_abnormal_urinary_bladder0.66300974
94MP0002233_abnormal_nose_morphology0.66183291
95MP0000749_muscle_degeneration0.64961142
96MP0003300_gastrointestinal_ulcer0.64879048
97MP0003950_abnormal_plasma_membrane0.63226818
98MP0001177_atelectasis0.62013726
99MP0004087_abnormal_muscle_fiber0.61872054
100MP0000759_abnormal_skeletal_muscle0.60883658
101MP0005369_muscle_phenotype0.60696228
102MP0001270_distended_abdomen0.59958831
103MP0005248_abnormal_Harderian_gland0.59475727
104MP0002114_abnormal_axial_skeleton0.57672934
105MP0005377_hearing/vestibular/ear_phenot0.56869374
106MP0003878_abnormal_ear_physiology0.56869374
107MP0004036_abnormal_muscle_relaxation0.56749753
108MP0005670_abnormal_white_adipose0.56658773
109* MP0005193_abnormal_anterior_eye0.56639706
110MP0008004_abnormal_stomach_pH0.56402042
111MP0005409_darkened_coat_color0.54854390
112* MP0003448_altered_tumor_morphology0.53290077
113MP0000249_abnormal_blood_vessel0.52369589
114MP0000537_abnormal_urethra_morphology0.50931190
115MP0000747_muscle_weakness0.49512700
116MP0003937_abnormal_limbs/digits/tail_de0.48934655
117MP0002972_abnormal_cardiac_muscle0.48757510

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.86202285
2Premature rupture of membranes (HP:0001788)7.07719115
3Aortic dissection (HP:0002647)4.50112338
4Neonatal short-limb short stature (HP:0008921)4.24719863
5Soft skin (HP:0000977)4.12497794
6Ankle contracture (HP:0006466)4.11142963
7Cerebral aneurysm (HP:0004944)4.06395612
8Broad metatarsal (HP:0001783)3.98920480
9Epiphyseal dysplasia (HP:0002656)3.95843386
10Atrophic scars (HP:0001075)3.88355245
11Shallow orbits (HP:0000586)3.87438286
12Abnormality of dentin (HP:0010299)3.82939692
13Aortic aneurysm (HP:0004942)3.79979569
14Cervical subluxation (HP:0003308)3.74453802
15Bladder diverticulum (HP:0000015)3.71071308
16Hypoplastic ischia (HP:0003175)3.45896079
17Follicular hyperkeratosis (HP:0007502)3.38955291
18Wormian bones (HP:0002645)3.36352981
19Vertebral compression fractures (HP:0002953)3.32256803
20Biconcave vertebral bodies (HP:0004586)3.30209668
21Peritonitis (HP:0002586)3.24190763
22Fragile skin (HP:0001030)3.22010173
23Blue sclerae (HP:0000592)3.18457212
24Dilatation of the ascending aorta (HP:0005111)3.16772357
25Genu recurvatum (HP:0002816)3.15651237
26Spinal rigidity (HP:0003306)3.08430864
27Mild short stature (HP:0003502)3.08398988
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.06865843
29Abnormality of the ischium (HP:0003174)3.05574046
30Osteoarthritis (HP:0002758)3.04528502
31Mitral valve prolapse (HP:0001634)3.04291373
32Vitreoretinal degeneration (HP:0000655)3.03280253
33Vascular tortuosity (HP:0004948)3.02246757
34Type 1 muscle fiber predominance (HP:0003803)2.93712182
35Cupped ribs (HP:0000887)2.91707848
36Coxa vara (HP:0002812)2.81765304
37Abnormality of the acetabulum (HP:0003170)2.78471748
38Arterial tortuosity (HP:0005116)2.72377683
39Irregular epiphyses (HP:0010582)2.67251228
40Platyspondyly (HP:0000926)2.66140357
41Aortic regurgitation (HP:0001659)2.63541854
42Hypoplasia of the iris (HP:0007676)2.60797357
43Increased connective tissue (HP:0009025)2.58204177
44Overgrowth (HP:0001548)2.57349575
45Hyperextensible skin (HP:0000974)2.56179876
46Metaphyseal cupping (HP:0003021)2.54979587
47Joint laxity (HP:0001388)2.41664002
48Mitral stenosis (HP:0001718)2.37001654
49Abnormal delivery (HP:0001787)2.35320718
50Beaking of vertebral bodies (HP:0004568)2.34645888
51Nonimmune hydrops fetalis (HP:0001790)2.30320447
52Coronal craniosynostosis (HP:0004440)2.29872408
53Aortic valve stenosis (HP:0001650)2.29381296
54Bowel diverticulosis (HP:0005222)2.29180571
55Hip contracture (HP:0003273)2.28524787
56Broad ribs (HP:0000885)2.25521531
57Wide anterior fontanel (HP:0000260)2.25086212
58Small epiphyses (HP:0010585)2.24267658
59Wrist flexion contracture (HP:0001239)2.23539256
60Absent frontal sinuses (HP:0002688)2.23526286
61Limited hip movement (HP:0008800)2.23020924
62Venous insufficiency (HP:0005293)2.22365105
63Increased variability in muscle fiber diameter (HP:0003557)2.22276557
64Ectopia lentis (HP:0001083)2.22080091
65Round ear (HP:0100830)2.21953145
66Aneurysm (HP:0002617)2.21011415
67Elbow flexion contracture (HP:0002987)2.15710768
68Mildly elevated creatine phosphokinase (HP:0008180)2.13871164
69Slender build (HP:0001533)2.10459173
70Flat acetabular roof (HP:0003180)2.10445416
71Broad long bones (HP:0005622)2.09124698
72Mesomelia (HP:0003027)2.07591699
73Abnormal vertebral ossification (HP:0100569)2.06500002
74Pulmonary artery stenosis (HP:0004415)2.04686120
75Hypoventilation (HP:0002791)2.04622289
76Bell-shaped thorax (HP:0001591)2.03611274
77Spondylolisthesis (HP:0003302)2.01667557
78Camptodactyly of toe (HP:0001836)1.99288740
79Joint stiffness (HP:0001387)1.98001925
80Ovoid vertebral bodies (HP:0003300)1.95383992
81Abnormality of skeletal muscle fiber size (HP:0012084)1.95348712
82Delayed epiphyseal ossification (HP:0002663)1.94125983
83Abnormal tarsal ossification (HP:0008369)1.93921705
84Lumbar hyperlordosis (HP:0002938)1.93025913
85Short hallux (HP:0010109)1.90869066
86Exostoses (HP:0100777)1.90751025
87Knee flexion contracture (HP:0006380)1.89606444
88Breech presentation (HP:0001623)1.89432017
89Decreased skull ossification (HP:0004331)1.87606705
90Genu varum (HP:0002970)1.87444276
91Flat capital femoral epiphysis (HP:0003370)1.87394290
92Mitral regurgitation (HP:0001653)1.87116142
93Tibial bowing (HP:0002982)1.86430185
94Increased corneal curvature (HP:0100692)1.86131028
95Keratoconus (HP:0000563)1.86131028
96Osteolytic defects of the hand bones (HP:0009699)1.85881246
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.85881246
98Infantile muscular hypotonia (HP:0008947)1.85439767
99Renal duplication (HP:0000075)1.84137315
100Deviation of the hallux (HP:0010051)1.83835254
101Osteopenia (HP:0000938)1.83828473
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83517738
103Femoral bowing (HP:0002980)1.83297970
104Spinal cord compression (HP:0002176)1.81904679
105Striae distensae (HP:0001065)1.80560313
106Thoracolumbar scoliosis (HP:0002944)1.80041698
107Ulnar bowing (HP:0003031)1.79811627
108Inguinal hernia (HP:0000023)1.78385976
109Morphological abnormality of the middle ear (HP:0008609)1.77568191
110Hallux valgus (HP:0001822)1.75477366
111Radial bowing (HP:0002986)1.75409742
112Flattened epiphyses (HP:0003071)1.75320306
113Venous abnormality (HP:0002624)1.75159146
114Abnormality of skull ossification (HP:0002703)1.74210520
115Thin ribs (HP:0000883)1.73842257
116Protruding ear (HP:0000411)1.73478417
117Calcaneovalgus deformity (HP:0001848)1.72801799
118Aplasia/Hypoplasia of the hallux (HP:0008362)1.72378274
119Delayed gross motor development (HP:0002194)1.72329637
120Disproportionate tall stature (HP:0001519)1.71954517
121Deformed tarsal bones (HP:0008119)1.71066654
122Abnormality of the anterior chamber (HP:0000593)1.70367199
123Thin skin (HP:0000963)1.66709391
124Limb-girdle muscle weakness (HP:0003325)1.66599230
125Flat cornea (HP:0007720)1.65067180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.01556246
2TRIB34.03836688
3PDGFRA3.12869537
4LATS23.00444000
5LATS12.78370987
6KDR2.66267286
7TGFBR22.66241756
8EPHB22.56278107
9TIE12.36358383
10TTN2.31651703
11ERN12.25064067
12PIM22.21439852
13PKN22.21198820
14RIPK12.13785653
15SIK11.92618058
16FER1.91907767
17PAK21.86359491
18PTK2B1.84067548
19MYLK1.80430914
20PAK41.52900723
21DMPK1.52698997
22MAP3K31.46357615
23STK38L1.45929365
24PTK61.43375085
25PTK21.43053467
26TESK11.35445898
27EPHA31.34444814
28MET1.32809506
29PRKD31.31665757
30TRPM71.31645114
31TGFBR11.30378544
32PAK31.26930055
33BMX1.24892603
34INSRR1.22965617
35EPHB11.21500050
36LIMK11.21236019
37ROCK11.20844742
38PRKG21.19698190
39MUSK1.18857653
40NEK91.18570605
41STK31.15947300
42ERBB31.12965844
43MARK11.12446860
44PDGFRB1.06058462
45FGFR11.05098751
46PDK21.04420817
47LRRK21.03799041
48PLK21.02815436
49ERBB40.98629342
50ABL20.97562668
51NTRK10.94533818
52PIK3CA0.93854069
53ILK0.93499266
54KIT0.91506457
55MOS0.84596127
56CAMK1D0.84513985
57MTOR0.80703253
58MAP2K10.77179339
59RPS6KA40.75483340
60PRKD10.74056752
61CDC42BPA0.73028346
62DAPK30.70502642
63RET0.70366569
64RPS6KA20.69961489
65PNCK0.68496998
66LMTK20.68143061
67ROCK20.67678535
68TAOK10.66175286
69NUAK10.65057014
70CDK60.64734190
71PRKCH0.64319870
72NTRK20.63039758
73TYRO30.62994017
74MAP3K60.61502949
75DYRK1B0.61295046
76CAMK2G0.61168731
77AKT30.58129921
78PRKD20.56380659
79INSR0.56358330
80CAMK1G0.55676191
81STK240.55508587
82FGFR20.54974273
83FGFR30.53481212
84WNK10.52443041
85ARAF0.51177109
86CLK10.51049286
87TNIK0.49720465
88GSK3A0.49092053
89MAPK120.46969293
90CAMK2D0.45488752
91CAMKK10.44586788
92PAK60.44454323
93SRC0.43439574
94FRK0.42179814
95JAK10.42102126
96CAMK2B0.41805204
97MAPK70.38775175
98CDK150.38709530
99EPHA20.37984230
100PIK3CG0.37167281
101CDK180.36502574
102IGF1R0.36328481
103SCYL20.35205472
104CDK11A0.34027568
105PAK10.33330632
106CDK80.31257320
107PRKCE0.30857119
108MAP3K100.30828434
109CDK140.30510039
110FGFR40.30386524
111MELK0.30046689
112ERBB20.29739376
113MAPKAPK30.29602029
114STK380.28923962
115ADRBK10.28890369
116MAP2K20.28516565
117CDK90.28039293
118CAMKK20.28031055
119MAPK40.27318266
120MAP3K120.27297996
121KSR20.27146770
122PRKG10.26997193
123MAPK10.25607720
124FLT30.23322221
125EGFR0.21889258
126ABL10.21531368
127MAP2K30.20455596
128CAMK40.16259371

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.04874359
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.50598064
3Protein digestion and absorption_Homo sapiens_hsa049743.31274318
4Focal adhesion_Homo sapiens_hsa045103.28924638
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.23389744
6Proteoglycans in cancer_Homo sapiens_hsa052052.13973440
7TGF-beta signaling pathway_Homo sapiens_hsa043502.12150634
8Amoebiasis_Homo sapiens_hsa051462.11701876
9Malaria_Homo sapiens_hsa051442.01943896
10Dilated cardiomyopathy_Homo sapiens_hsa054141.95045272
11Adherens junction_Homo sapiens_hsa045201.92075999
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90563386
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90185129
14PI3K-Akt signaling pathway_Homo sapiens_hsa041511.83002100
15Hippo signaling pathway_Homo sapiens_hsa043901.82604143
16Small cell lung cancer_Homo sapiens_hsa052221.78236473
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74133527
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63491169
19Bladder cancer_Homo sapiens_hsa052191.59398655
20Basal cell carcinoma_Homo sapiens_hsa052171.54071371
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44830847
22Hedgehog signaling pathway_Homo sapiens_hsa043401.40960808
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32650650
24MicroRNAs in cancer_Homo sapiens_hsa052061.20619111
25Melanoma_Homo sapiens_hsa052181.20226693
26Chronic myeloid leukemia_Homo sapiens_hsa052201.17992225
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.16257117
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15838258
29Rap1 signaling pathway_Homo sapiens_hsa040151.12895941
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11264817
31Tight junction_Homo sapiens_hsa045301.09010204
32Pathways in cancer_Homo sapiens_hsa052001.06867972
33Wnt signaling pathway_Homo sapiens_hsa043101.06243190
34Platelet activation_Homo sapiens_hsa046111.04207853
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04207540
36Prostate cancer_Homo sapiens_hsa052151.01786189
37Axon guidance_Homo sapiens_hsa043601.01285469
38Glioma_Homo sapiens_hsa052141.00216020
39Viral myocarditis_Homo sapiens_hsa054160.96275702
40Toxoplasmosis_Homo sapiens_hsa051450.96167481
41Melanogenesis_Homo sapiens_hsa049160.95992612
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89998981
43Complement and coagulation cascades_Homo sapiens_hsa046100.89289391
44Pancreatic cancer_Homo sapiens_hsa052120.88554480
45TNF signaling pathway_Homo sapiens_hsa046680.87650635
46Gap junction_Homo sapiens_hsa045400.86575120
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86219736
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85760541
49Thyroid hormone synthesis_Homo sapiens_hsa049180.85292442
50Estrogen signaling pathway_Homo sapiens_hsa049150.84975902
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83850626
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82748211
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82715702
54Ovarian steroidogenesis_Homo sapiens_hsa049130.81614971
55HIF-1 signaling pathway_Homo sapiens_hsa040660.80528550
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.79596125
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79473656
58PPAR signaling pathway_Homo sapiens_hsa033200.79079121
59Renal cell carcinoma_Homo sapiens_hsa052110.78174721
60HTLV-I infection_Homo sapiens_hsa051660.77386885
61Vibrio cholerae infection_Homo sapiens_hsa051100.77349018
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.75998765
63Ras signaling pathway_Homo sapiens_hsa040140.74162312
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.72184183
65Colorectal cancer_Homo sapiens_hsa052100.70626301
66Notch signaling pathway_Homo sapiens_hsa043300.68696374
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66632797
68Cocaine addiction_Homo sapiens_hsa050300.65871801
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65669534
70Phagosome_Homo sapiens_hsa041450.65051390
71Lysosome_Homo sapiens_hsa041420.63376063
72Insulin resistance_Homo sapiens_hsa049310.60817899
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.60523052
74Endocytosis_Homo sapiens_hsa041440.59332891
75Shigellosis_Homo sapiens_hsa051310.59268403
76Renin-angiotensin system_Homo sapiens_hsa046140.57982017
77Endometrial cancer_Homo sapiens_hsa052130.57978440
78p53 signaling pathway_Homo sapiens_hsa041150.57595396
79VEGF signaling pathway_Homo sapiens_hsa043700.56416036
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.55519053
81N-Glycan biosynthesis_Homo sapiens_hsa005100.55342226
82GnRH signaling pathway_Homo sapiens_hsa049120.53423092
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53351681
84Oxytocin signaling pathway_Homo sapiens_hsa049210.51408267
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51360973
86Prion diseases_Homo sapiens_hsa050200.51176460
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50189207
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49900614
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49036107
90Dorso-ventral axis formation_Homo sapiens_hsa043200.48465275
91Gastric acid secretion_Homo sapiens_hsa049710.48383645
92cAMP signaling pathway_Homo sapiens_hsa040240.48354875
93Thyroid cancer_Homo sapiens_hsa052160.47789495
94Hepatitis B_Homo sapiens_hsa051610.46999775
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.46878017
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46750950
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45991499
98Renin secretion_Homo sapiens_hsa049240.45469608
99Apoptosis_Homo sapiens_hsa042100.44985310
100AMPK signaling pathway_Homo sapiens_hsa041520.44918476
101FoxO signaling pathway_Homo sapiens_hsa040680.44112187
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43025935
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42447133
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42335165
105mTOR signaling pathway_Homo sapiens_hsa041500.41332186
106Fatty acid elongation_Homo sapiens_hsa000620.41195166
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40530030
108MAPK signaling pathway_Homo sapiens_hsa040100.40509877
109Salmonella infection_Homo sapiens_hsa051320.39361493
110Other glycan degradation_Homo sapiens_hsa005110.39164731
111Choline metabolism in cancer_Homo sapiens_hsa052310.38319387
112Circadian entrainment_Homo sapiens_hsa047130.36487521
113Pertussis_Homo sapiens_hsa051330.35505890
114Cholinergic synapse_Homo sapiens_hsa047250.34392973
115Galactose metabolism_Homo sapiens_hsa000520.33763462
116Calcium signaling pathway_Homo sapiens_hsa040200.32394786
117Glutamatergic synapse_Homo sapiens_hsa047240.31352310
118Lysine degradation_Homo sapiens_hsa003100.30914183
119Pancreatic secretion_Homo sapiens_hsa049720.28918579

Most similar genes based on co-expression Upload to Enrichr

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