SPAG6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.93212878
2axonemal dynein complex assembly (GO:0070286)9.91770024
3epithelial cilium movement (GO:0003351)9.59904922
4motile cilium assembly (GO:0044458)9.48191328
5* spermatid development (GO:0007286)8.92413598
6regulation of cilium movement (GO:0003352)8.54143069
7cilium movement (GO:0003341)8.04048543
8single fertilization (GO:0007338)7.63240081
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.52946501
10sperm capacitation (GO:0048240)7.48209280
11left/right axis specification (GO:0070986)7.48029975
12male meiosis (GO:0007140)7.42510008
13piRNA metabolic process (GO:0034587)7.36840795
14synaptonemal complex organization (GO:0070193)7.06557050
15synaptonemal complex assembly (GO:0007130)6.87055421
16negative regulation of inclusion body assembly (GO:0090084)6.43986497
17microtubule bundle formation (GO:0001578)6.40275054
18primary alcohol catabolic process (GO:0034310)6.32348262
19fertilization (GO:0009566)6.28952007
20microtubule depolymerization (GO:0007019)6.22966135
21spermatogenesis (GO:0007283)6.19661584
22male gamete generation (GO:0048232)6.17418327
23organic cation transport (GO:0015695)5.95383071
24vitamin transmembrane transport (GO:0035461)5.76844949
25calcium ion-dependent exocytosis (GO:0017156)5.76290121
26gamete generation (GO:0007276)5.68036716
27diterpenoid biosynthetic process (GO:0016102)5.56138070
28ventricular system development (GO:0021591)5.38958131
29regulation of inclusion body assembly (GO:0090083)5.34549334
30ethanol metabolic process (GO:0006067)5.33170974
31cell recognition (GO:0008037)5.29263748
32* cellular process involved in reproduction in multicellular organism (GO:0022412)5.21869475
33spermatid nucleus differentiation (GO:0007289)5.00893101
34regulation of microtubule-based movement (GO:0060632)4.99362848
35* germ cell development (GO:0007281)4.96555238
36microtubule severing (GO:0051013)4.91727648
37DNA methylation involved in gamete generation (GO:0043046)4.79323475
38male meiosis I (GO:0007141)4.71984852
39chromosome organization involved in meiosis (GO:0070192)4.70158869
40cell projection assembly (GO:0030031)4.58473136
41lung epithelium development (GO:0060428)4.57472341
42response to xenobiotic stimulus (GO:0009410)4.57291579
43multicellular organismal reproductive process (GO:0048609)4.46269200
44one-carbon compound transport (GO:0019755)4.45796869
45pyrimidine-containing compound transmembrane transport (GO:0072531)4.44271935
46tolerance induction (GO:0002507)4.38734672
47meiotic nuclear division (GO:0007126)4.26310717
48seminiferous tubule development (GO:0072520)4.23980405
49glycerol ether metabolic process (GO:0006662)4.19777106
50left/right pattern formation (GO:0060972)4.17098244
51establishment of apical/basal cell polarity (GO:0035089)4.10778922
52negative regulation of T cell differentiation in thymus (GO:0033085)4.07232629
53glomerular epithelial cell development (GO:0072310)4.04542868
54regulation of interleukin-5 production (GO:0032674)4.03001659
55chromosome condensation (GO:0030261)4.02539302
56ethanol oxidation (GO:0006069)3.99996422
57negative regulation of immunoglobulin mediated immune response (GO:0002890)3.91519469
58negative regulation of B cell mediated immunity (GO:0002713)3.91519469
59ether metabolic process (GO:0018904)3.87617418
60protein polyglutamylation (GO:0018095)3.84108303
61terpenoid biosynthetic process (GO:0016114)3.83798936
62protein localization to cilium (GO:0061512)3.83173015
63DNA packaging (GO:0006323)3.81539073
64meiosis I (GO:0007127)3.75550956
65cytoplasmic microtubule organization (GO:0031122)3.75471146
66retinoic acid metabolic process (GO:0042573)3.75276462
67chaperone-mediated protein complex assembly (GO:0051131)3.74582339
68negative regulation of humoral immune response (GO:0002921)3.73010115
69multicellular organismal development (GO:0007275)3.63717142
70monoubiquitinated protein deubiquitination (GO:0035520)3.63201821
71establishment of monopolar cell polarity (GO:0061162)3.63141304
72establishment or maintenance of monopolar cell polarity (GO:0061339)3.63141304
73regulation of interleukin-13 production (GO:0032656)3.61633716
74regulation of germinal center formation (GO:0002634)3.54192649
75negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.52368756
76lateral ventricle development (GO:0021670)3.51029029
77positive regulation of tolerance induction (GO:0002645)3.41460273
78determination of left/right symmetry (GO:0007368)3.36316963
79genitalia morphogenesis (GO:0035112)3.30371360
80determination of bilateral symmetry (GO:0009855)3.29258130
81protein K11-linked deubiquitination (GO:0035871)3.27284228
82smoothened signaling pathway (GO:0007224)3.25742236
83meiotic cell cycle (GO:0051321)3.23832524
84specification of symmetry (GO:0009799)3.21753447
85establishment of tissue polarity (GO:0007164)3.18490404
86establishment of planar polarity (GO:0001736)3.18490404
87microtubule polymerization or depolymerization (GO:0031109)3.18386563
88carnitine transport (GO:0015879)3.11741357
89amino-acid betaine transport (GO:0015838)3.11741357
90retinal rod cell development (GO:0046548)3.11374469
91intraciliary transport (GO:0042073)3.09408339
92polyol catabolic process (GO:0046174)3.08738090
93single strand break repair (GO:0000012)3.06983252
94positive regulation of smoothened signaling pathway (GO:0045880)3.03979961
95sexual reproduction (GO:0019953)3.03014189
96microtubule-based process (GO:0007017)3.02692068
97carnitine transmembrane transport (GO:1902603)2.99399729
98microtubule-based movement (GO:0007018)2.99330567
99cilium organization (GO:0044782)2.98710719
100regulation of spindle checkpoint (GO:0090231)2.97428353
101nucleoside diphosphate phosphorylation (GO:0006165)2.97328264
102glycolytic process (GO:0006096)2.94827430
103cilium morphogenesis (GO:0060271)2.92705262
104organelle assembly (GO:0070925)2.91282905
105exogenous drug catabolic process (GO:0042738)2.91000239
106axoneme assembly (GO:0035082)2.88268295
107cilium assembly (GO:0042384)2.88039086
108retinol metabolic process (GO:0042572)2.87050972
109cellular component assembly involved in morphogenesis (GO:0010927)2.86964224
110protein refolding (GO:0042026)2.85297787
111primary alcohol metabolic process (GO:0034308)2.84502130
112synapsis (GO:0007129)2.83024208
113negative regulation of organelle assembly (GO:1902116)2.81615161
114sequestering of actin monomers (GO:0042989)2.80933216
115alditol metabolic process (GO:0019400)2.80624474
116positive regulation of macrophage activation (GO:0043032)2.78470756
117lateral sprouting from an epithelium (GO:0060601)2.77171432
118lactate metabolic process (GO:0006089)2.76914870
119centriole assembly (GO:0098534)2.76241165
120O-glycan processing (GO:0016266)2.75370122
121GTP biosynthetic process (GO:0006183)2.73944718
122embryonic camera-type eye development (GO:0031076)2.73488588
123regulation of microtubule depolymerization (GO:0031114)2.72283000
124carnitine metabolic process (GO:0009437)2.71407443
125intra-S DNA damage checkpoint (GO:0031573)2.71283741
126glutathione derivative biosynthetic process (GO:1901687)2.71250305
127glutathione derivative metabolic process (GO:1901685)2.71250305
128nucleus organization (GO:0006997)2.71004165
129apical protein localization (GO:0045176)2.68247896
130meiotic cell cycle process (GO:1903046)2.68134256
131gene silencing by RNA (GO:0031047)2.64605726
132photoreceptor cell maintenance (GO:0045494)2.62682269
133heart looping (GO:0001947)2.61418494
134phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.59520235
135peptidyl-glutamic acid modification (GO:0018200)2.57494023
136centriole replication (GO:0007099)2.54307368
137nonmotile primary cilium assembly (GO:0035058)2.51864999
138CDP-diacylglycerol biosynthetic process (GO:0016024)2.50807588
139interferon-gamma secretion (GO:0072643)2.49948216
140calcium ion import (GO:0070509)2.49616830
141hydrogen peroxide biosynthetic process (GO:0050665)2.49602217
142regulation of centriole replication (GO:0046599)2.48189792
143aldehyde catabolic process (GO:0046185)2.48154343
144mitotic sister chromatid cohesion (GO:0007064)2.48043071
145regulation of autophagic vacuole assembly (GO:2000785)2.47015811
146regulation of cilium assembly (GO:1902017)2.45263802
147glycerol metabolic process (GO:0006071)2.44928582
148regulation of tolerance induction (GO:0002643)2.43802599
149UTP biosynthetic process (GO:0006228)2.40564028
150multicellular organismal water homeostasis (GO:0050891)2.39908532
151progesterone metabolic process (GO:0042448)2.38361116
152regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.37678321
153embryonic heart tube morphogenesis (GO:0003143)2.35595265
154phosphatidylcholine biosynthetic process (GO:0006656)2.34662768
155regulation of collateral sprouting (GO:0048670)2.34328020
156asymmetric protein localization (GO:0008105)2.30649308
157regulation of smoothened signaling pathway (GO:0008589)2.30193183
158excretion (GO:0007588)2.26814772
159drug catabolic process (GO:0042737)2.26245462
160cell wall macromolecule catabolic process (GO:0016998)14.5769010
161cell wall macromolecule metabolic process (GO:0044036)14.5769010
162fusion of sperm to egg plasma membrane (GO:0007342)14.4185314
163sperm motility (GO:0030317)12.7943080
164acrosome assembly (GO:0001675)12.2890895
165multicellular organism reproduction (GO:0032504)11.9041250
166sperm-egg recognition (GO:0035036)11.8582305
167acrosome reaction (GO:0007340)11.3329634
168plasma membrane fusion (GO:0045026)11.0889238
169cilium or flagellum-dependent cell motility (GO:0001539)11.0023588
170cell-cell recognition (GO:0009988)10.6167131
171binding of sperm to zona pellucida (GO:0007339)10.3536192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.29013656
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.73861025
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.64725159
4EZH2_22144423_ChIP-Seq_EOC_Human4.50580184
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.83015882
6DROSHA_22980978_ChIP-Seq_HELA_Human3.19145952
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.14835592
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77737787
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63769098
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52426109
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31517134
12VDR_22108803_ChIP-Seq_LS180_Human2.25906160
13ZNF274_21170338_ChIP-Seq_K562_Hela2.20889936
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.16456368
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.15885762
16* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08543532
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05202391
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02514970
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.98134241
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96388618
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94228776
22AHR_22903824_ChIP-Seq_MCF-7_Human1.93406994
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92661029
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.91021085
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.88061506
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.87288316
27* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.83744360
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.83592951
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.83496855
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.80299941
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.79976022
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72532949
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67440360
34SMC4_20622854_ChIP-Seq_HELA_Human1.67144373
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.65612646
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64911851
37STAT1_17558387_ChIP-Seq_HELA_Human1.63335385
38GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.61378000
39KDM2B_26808549_Chip-Seq_REH_Human1.60467599
40TP63_23658742_ChIP-Seq_EP156T_Human1.58034975
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.57462339
42STAT1_20625510_ChIP-Seq_HELA_Human1.55575203
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54102439
44KAP1_22055183_ChIP-Seq_ESCs_Mouse1.53551858
45FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53374159
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52822119
47ETV1_20927104_ChIP-Seq_GIST48_Human1.51235975
48FOXA1_25552417_ChIP-Seq_VCAP_Human1.50437745
49REST_21632747_ChIP-Seq_MESCs_Mouse1.50347329
50CBP_20019798_ChIP-Seq_JUKART_Human1.50081411
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50081411
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.49588835
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49348959
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46955470
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45767748
56* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42705341
57PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.41649810
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41461281
59* RUNX1_27514584_Chip-Seq_MCF-7_Human1.40854666
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.39593533
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.39589127
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39423004
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39390908
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.39133238
65* PHF8_20622853_ChIP-Seq_HELA_Human1.38574655
66SMAD4_21799915_ChIP-Seq_A2780_Human1.38039026
67* GATA3_21867929_ChIP-Seq_CD8_Mouse1.37942835
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37187027
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37177125
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37017019
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35437075
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35342043
73SMRT_27268052_Chip-Seq_Bcells_Human1.33319674
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33258773
75KLF5_25053715_ChIP-Seq_YYC3_Human1.32437748
76LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31735816
77TP53_18474530_ChIP-ChIP_U2OS_Human1.31502004
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31335728
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31128940
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30828621
81* HNFA_21074721_ChIP-Seq_CACO-2_Human1.30277652
82TP63_22573176_ChIP-Seq_HFKS_Human1.26581141
83TDRD3_21172665_ChIP-Seq_MCF-7_Human1.24671426
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24608835
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.24571246
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24119969
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23319957
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.22917445
89RBPJ_21746931_ChIP-Seq_IB4_Human1.22352840
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21667520
91AR_21572438_ChIP-Seq_LNCaP_Human1.21060353
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20494085
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.19691627
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.19542701
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.18498580
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18065249
97GF1_26923725_Chip-Seq_HPCs_Mouse1.17600442
98FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17194282
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17082058
100P53_21459846_ChIP-Seq_SAOS-2_Human1.16911243
101CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16048751
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.15123143
103BCAT_22108803_ChIP-Seq_LS180_Human1.14828697
104P53_22387025_ChIP-Seq_ESCs_Mouse1.13957838
105STAT3_23295773_ChIP-Seq_U87_Human1.13574512
106GATA6_21074721_ChIP-Seq_CACO-2_Human1.13474211
107* NFYA_21822215_ChIP-Seq_K562_Human1.13385806
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13269962
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13236076
110RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13111855
111RNF2_27304074_Chip-Seq_NSC_Mouse1.12894278
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.12166693
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11455719
114* NFYB_21822215_ChIP-Seq_K562_Human1.11182193
115TAF15_26573619_Chip-Seq_HEK293_Human1.09952650
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09910766
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09910766
118SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09547938
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09334548
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08840878
121* TBL1_22424771_ChIP-Seq_293T_Human1.07874067
122P300_18555785_Chip-Seq_ESCs_Mouse1.07660742
123CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07392864
124GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07294463
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.07259132
126TP53_16413492_ChIP-PET_HCT116_Human1.07116644
127YY1_22570637_ChIP-Seq_MALME-3M_Human1.06834119
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.06363515
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.05529147
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04844389
131SOX2_20726797_ChIP-Seq_SW620_Human1.04319722
132P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03937389
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03728710
134RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03360944
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02855132
136ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02611623
137SPI1_26923725_Chip-Seq_HPCs_Mouse1.02558906
138GATA1_19941826_ChIP-Seq_K562_Human1.02515167
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02513816
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02179444
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02113336
142TCF4_22108803_ChIP-Seq_LS180_Human1.01994811
143CEBPB_22108803_ChIP-Seq_LS180_Human1.01871147
144SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01328280
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01226016
146OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00628026
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99501174
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.99463308
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.99345001
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99207022
151EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98704324
152CTCF_20526341_ChIP-Seq_ESCs_Human0.98555089
153AR_20517297_ChIP-Seq_VCAP_Human0.96553223
154SOX2_18555785_Chip-Seq_ESCs_Mouse0.95884733
155STAT3_18555785_Chip-Seq_ESCs_Mouse0.95612816
156SOX9_26525672_Chip-Seq_HEART_Mouse0.95379940
157PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93880385
158CTCF_18555785_Chip-Seq_ESCs_Mouse0.93321631
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93249178
160GATA4_25053715_ChIP-Seq_YYC3_Human0.93158564
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.93144573
162PU1_27457419_Chip-Seq_LIVER_Mouse0.92342938
163FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92276313
164FOXA1_25329375_ChIP-Seq_VCAP_Human0.92276313
165GATA3_24758297_ChIP-Seq_MCF-7_Human0.92263424
166CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92193665
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92180235
168TCF4_23295773_ChIP-Seq_U87_Human0.92113745
169BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92096402
170RARA_24833708_ChIP-Seq_LIVER_Mouse0.91959695
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.91896866
172FOXA2_19822575_ChIP-Seq_HepG2_Human0.91836684
173ESET_19884257_ChIP-Seq_ESCs_Mouse0.91757635
174CTCF_27219007_Chip-Seq_Bcells_Human0.91502909
175STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91406500
176MYC_27129775_Chip-Seq_CORNEA_Mouse0.91280714
177GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90851741
178VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90555314
179RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90255977
180LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89984477
181FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89820152
182ERG_20517297_ChIP-Seq_VCAP_Human0.89265007
183FLI1_21867929_ChIP-Seq_CD8_Mouse0.89184306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.91869662
2MP0008875_abnormal_xenobiotic_pharmacok5.69617085
3* MP0001929_abnormal_gametogenesis5.32867990
4MP0002132_abnormal_respiratory_system4.77244884
5MP0008877_abnormal_DNA_methylation4.43163288
6MP0008789_abnormal_olfactory_epithelium3.76106096
7MP0002277_abnormal_respiratory_mucosa3.49830121
8MP0009780_abnormal_chondrocyte_physiolo3.44974350
9MP0002210_abnormal_sex_determination3.38451428
10MP0000566_synostosis3.33114823
11* MP0002161_abnormal_fertility/fecundity3.18795430
12MP0002653_abnormal_ependyma_morphology3.08341714
13MP0001145_abnormal_male_reproductive2.87505391
14MP0005499_abnormal_olfactory_system2.71845290
15MP0005394_taste/olfaction_phenotype2.71845290
16MP0000383_abnormal_hair_follicle2.65828471
17MP0000653_abnormal_sex_gland2.52763414
18MP0000678_abnormal_parathyroid_gland2.40771291
19MP0005670_abnormal_white_adipose2.35893045
20MP0010678_abnormal_skin_adnexa2.28247702
21MP0004019_abnormal_vitamin_homeostasis2.00060585
22MP0005410_abnormal_fertilization15.9050147
23MP0005623_abnormal_meninges_morphology1.91323009
24MP0002638_abnormal_pupillary_reflex1.85593677
25MP0002249_abnormal_larynx_morphology1.85112942
26MP0009046_muscle_twitch1.76134621
27MP0003136_yellow_coat_color1.72446665
28MP0004233_abnormal_muscle_weight1.72412462
29MP0001485_abnormal_pinna_reflex1.71763334
30MP0003646_muscle_fatigue1.68947342
31MP0002160_abnormal_reproductive_system1.64277018
32MP0002168_other_aberrant_phenotype1.63188486
33MP0010030_abnormal_orbit_morphology1.62585286
34MP0001984_abnormal_olfaction1.51345159
35MP0003656_abnormal_erythrocyte_physiolo1.47267022
36MP0005083_abnormal_biliary_tract1.42371072
37MP0002233_abnormal_nose_morphology1.34181752
38MP0001346_abnormal_lacrimal_gland1.31484771
39MP0002282_abnormal_trachea_morphology1.28491935
40MP0001765_abnormal_ion_homeostasis1.20696954
41MP0010234_abnormal_vibrissa_follicle1.18300288
42MP0005395_other_phenotype1.18061371
43MP0000026_abnormal_inner_ear1.17319964
44MP0005248_abnormal_Harderian_gland1.10685666
45MP0003938_abnormal_ear_development1.04801433
46MP0000049_abnormal_middle_ear0.99597782
47MP0000681_abnormal_thyroid_gland0.96270387
48MP0002234_abnormal_pharynx_morphology0.90764939
49MP0005220_abnormal_exocrine_pancreas0.88219979
50MP0005365_abnormal_bile_salt0.86671013
51MP0004885_abnormal_endolymph0.86539210
52MP0008058_abnormal_DNA_repair0.84323682
53MP0005647_abnormal_sex_gland0.83635582
54MP0002876_abnormal_thyroid_physiology0.83263577
55MP0008995_early_reproductive_senescence0.82539542
56MP0002736_abnormal_nociception_after0.81197324
57MP0001963_abnormal_hearing_physiology0.80987274
58MP0000631_abnormal_neuroendocrine_gland0.79069503
59MP0001502_abnormal_circadian_rhythm0.78912656
60MP0005389_reproductive_system_phenotype0.78325125
61MP0004859_abnormal_synaptic_plasticity0.77540094
62MP0009703_decreased_birth_body0.76311476
63MP0003937_abnormal_limbs/digits/tail_de0.76078559
64MP0002116_abnormal_craniofacial_bone0.72316558
65MP0001270_distended_abdomen0.70858979
66MP0000467_abnormal_esophagus_morphology0.70807886
67MP0001968_abnormal_touch/_nociception0.69994585
68MP0003115_abnormal_respiratory_system0.68171225
69MP0005165_increased_susceptibility_to0.66695475
70MP0005391_vision/eye_phenotype0.66567821
71MP0002098_abnormal_vibrissa_morphology0.62987544
72MP0004036_abnormal_muscle_relaxation0.62437556
73MP0005085_abnormal_gallbladder_physiolo0.62316958
74MP0001299_abnormal_eye_distance/0.61925985
75MP0003329_amyloid_beta_deposits0.61606598
76MP0001944_abnormal_pancreas_morphology0.61369723
77MP0003635_abnormal_synaptic_transmissio0.61081115
78MP0004270_analgesia0.60523908
79MP0000569_abnormal_digit_pigmentation0.60147145
80MP0002084_abnormal_developmental_patter0.59880046
81MP0002735_abnormal_chemical_nociception0.59738006
82MP0005636_abnormal_mineral_homeostasis0.58551056
83MP0009643_abnormal_urine_homeostasis0.58189020
84MP0005195_abnormal_posterior_eye0.57600354
85MP0002102_abnormal_ear_morphology0.56983177
86MP0003890_abnormal_embryonic-extraembry0.56730015
87MP0005551_abnormal_eye_electrophysiolog0.56521506
88MP0002139_abnormal_hepatobiliary_system0.54268663
89MP0002572_abnormal_emotion/affect_behav0.53839385
90MP0001324_abnormal_eye_pigmentation0.52911273
91MP0002928_abnormal_bile_duct0.52834245
92MP0001849_ear_inflammation0.52785550
93MP0009379_abnormal_foot_pigmentation0.52542057
94MP0010155_abnormal_intestine_physiology0.52247820
95MP0001440_abnormal_grooming_behavior0.52097557
96MP0003879_abnormal_hair_cell0.51528634
97MP0008569_lethality_at_weaning0.50805899
98MP0001664_abnormal_digestion0.50315827
99MP0002136_abnormal_kidney_physiology0.50006404
100MP0003718_maternal_effect0.49904843
101MP0005503_abnormal_tendon_morphology0.49784185
102MP0002092_abnormal_eye_morphology0.49587838
103MP0004811_abnormal_neuron_physiology0.48681745
104MP0000465_gastrointestinal_hemorrhage0.48382539
105MP0002063_abnormal_learning/memory/cond0.48360035
106MP0003787_abnormal_imprinting0.47961713
107MP0002269_muscular_atrophy0.46788696
108MP0003633_abnormal_nervous_system0.46606970
109MP0010094_abnormal_chromosome_stability0.46330123
110MP0008961_abnormal_basal_metabolism0.46010907
111MP0004264_abnormal_extraembryonic_tissu0.45891732
112MP0009745_abnormal_behavioral_response0.44239359
113MP0006036_abnormal_mitochondrial_physio0.44226431
114MP0002133_abnormal_respiratory_system0.43757836
115MP0005388_respiratory_system_phenotype0.43757836
116MP0000358_abnormal_cell_content/0.43638860
117MP0003011_delayed_dark_adaptation0.43239346
118MP0002896_abnormal_bone_mineralization0.42601423
119MP0002064_seizures0.41196734
120MP0001188_hyperpigmentation0.40778970
121MP0003878_abnormal_ear_physiology0.40661424
122MP0005377_hearing/vestibular/ear_phenot0.40661424
123MP0005666_abnormal_adipose_tissue0.40422349
124MP0002272_abnormal_nervous_system0.39105058
125MP0004130_abnormal_muscle_cell0.38244710
126MP0005253_abnormal_eye_physiology0.38024097
127MP0004145_abnormal_muscle_electrophysio0.37362789
128MP0000751_myopathy0.36831803
129* MP0003699_abnormal_female_reproductive0.36810540
130MP0003631_nervous_system_phenotype0.34193213
131MP0002909_abnormal_adrenal_gland0.34182042
132MP0002837_dystrophic_cardiac_calcinosis0.34081482
133MP0003880_abnormal_central_pattern0.32774976
134MP0002734_abnormal_mechanical_nocicepti0.32121086
135MP0003950_abnormal_plasma_membrane0.31916968
136* MP0002152_abnormal_brain_morphology0.31645176
137MP0002971_abnormal_brown_adipose0.31607927
138MP0005535_abnormal_body_temperature0.30293436
139MP0000604_amyloidosis0.30273124
140MP0001764_abnormal_homeostasis0.30124379
141MP0001293_anophthalmia0.27925898
142MP0001119_abnormal_female_reproductive0.27860092
143MP0002557_abnormal_social/conspecific_i0.27642324
144MP0001545_abnormal_hematopoietic_system0.26997238
145MP0005397_hematopoietic_system_phenotyp0.26997238
146MP0010307_abnormal_tumor_latency0.26565694
147MP0005423_abnormal_somatic_nervous0.26530826
148MP0003786_premature_aging0.26369349
149MP0006035_abnormal_mitochondrial_morpho0.26308615
150MP0000534_abnormal_ureter_morphology0.25648768
151MP0001486_abnormal_startle_reflex0.25278776
152MP0002229_neurodegeneration0.24533252
153MP0009115_abnormal_fat_cell0.24504741
154MP0004043_abnormal_pH_regulation0.24099831
155MP0004133_heterotaxia0.23183489
156MP0002067_abnormal_sensory_capabilities0.22563179
157MP0002169_no_abnormal_phenotype0.22446595
158MP0002873_normal_phenotype0.22348211
159MP0004084_abnormal_cardiac_muscle0.22197446
160* MP0003861_abnormal_nervous_system0.21909154
161MP0004808_abnormal_hematopoietic_stem0.21748847
162MP0000955_abnormal_spinal_cord0.21198116
163MP0003942_abnormal_urinary_system0.21132469
164MP0002882_abnormal_neuron_morphology0.19974969
165MP0003183_abnormal_peptide_metabolism0.19963416
166MP0002066_abnormal_motor_capabilities/c0.19582075
167MP0003948_abnormal_gas_homeostasis0.19251690

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.31601766
2Abnormal respiratory motile cilium morphology (HP:0005938)8.95023185
3Abnormal respiratory epithelium morphology (HP:0012253)8.95023185
4Rhinitis (HP:0012384)7.72885715
5Abnormal ciliary motility (HP:0012262)7.50959939
6Chronic bronchitis (HP:0004469)7.15374163
7Infertility (HP:0000789)6.50358858
8Nasal polyposis (HP:0100582)6.41964684
9Abnormality of the nasal mucosa (HP:0000433)5.24228055
10Bronchitis (HP:0012387)4.53918509
11Bronchiectasis (HP:0002110)4.47047195
12Nephronophthisis (HP:0000090)4.24758132
13Male infertility (HP:0003251)4.23259104
14Occipital encephalocele (HP:0002085)4.01697526
15True hermaphroditism (HP:0010459)3.71516545
16Abnormal spermatogenesis (HP:0008669)3.42495150
17Recurrent sinusitis (HP:0011108)3.27559014
18Recurrent otitis media (HP:0000403)3.22785197
19Medial flaring of the eyebrow (HP:0010747)3.21894830
20Abnormality of the renal medulla (HP:0100957)3.16526452
21Atelectasis (HP:0100750)3.11180430
22Pancreatic cysts (HP:0001737)3.00677548
23Chronic hepatic failure (HP:0100626)2.92489537
24Chronic otitis media (HP:0000389)2.90045445
25Recurrent bronchitis (HP:0002837)2.79614739
26Abnormality of midbrain morphology (HP:0002418)2.77531361
27Molar tooth sign on MRI (HP:0002419)2.77531361
28Tubulointerstitial nephritis (HP:0001970)2.64737889
29Tubular atrophy (HP:0000092)2.56452542
30Hyperactive renin-angiotensin system (HP:0000841)2.53920136
31Tubulointerstitial abnormality (HP:0001969)2.42460692
32Azoospermia (HP:0000027)2.38301215
33Impulsivity (HP:0100710)2.36834809
34Cholecystitis (HP:0001082)2.25451307
35Abnormal gallbladder physiology (HP:0012438)2.25451307
36Gait imbalance (HP:0002141)2.14512577
37Congenital primary aphakia (HP:0007707)2.13740626
38Anencephaly (HP:0002323)2.12559033
39Gonadotropin excess (HP:0000837)2.12357247
40Tubulointerstitial fibrosis (HP:0005576)2.08136694
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3575906
42Dynein arm defect of respiratory motile cilia (HP:0012255)12.8802711
43Absent/shortened dynein arms (HP:0200106)12.8802711
44Male pseudohermaphroditism (HP:0000037)1.98586513
45Postaxial foot polydactyly (HP:0001830)1.96070309
46Sclerocornea (HP:0000647)1.88889659
47Polydipsia (HP:0001959)1.88718075
48Abnormal drinking behavior (HP:0030082)1.88718075
49Congenital hepatic fibrosis (HP:0002612)1.88358505
50Nephrogenic diabetes insipidus (HP:0009806)1.81849806
51Chronic sinusitis (HP:0011109)1.81517805
52Dyschromatopsia (HP:0007641)1.77846209
53Stage 5 chronic kidney disease (HP:0003774)1.76596586
54Abnormality of the lower motor neuron (HP:0002366)1.76539732
55Spastic tetraparesis (HP:0001285)1.76236766
56Furrowed tongue (HP:0000221)1.75498705
57Aplasia/Hypoplasia of the lens (HP:0008063)1.74548498
58Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73815584
59Postaxial hand polydactyly (HP:0001162)1.73469888
60Decreased central vision (HP:0007663)1.73309078
61Abnormality of the renal cortex (HP:0011035)1.72306769
62Pancreatic fibrosis (HP:0100732)1.71621777
63Facial cleft (HP:0002006)1.69550856
64Abnormality of saccadic eye movements (HP:0000570)1.69283183
65Genital tract atresia (HP:0001827)1.63026260
66Short ribs (HP:0000773)1.62835165
67Choroideremia (HP:0001139)1.62594427
68Heterotopia (HP:0002282)1.62263563
69Abnormality of ocular smooth pursuit (HP:0000617)1.60943623
70Abnormality of renal excretion (HP:0011036)1.60889828
71Poor coordination (HP:0002370)1.60579858
72Decreased circulating renin level (HP:0003351)1.59781770
73J-shaped sella turcica (HP:0002680)1.59324035
74Vaginal atresia (HP:0000148)1.59118500
75Oculomotor apraxia (HP:0000657)1.58445912
76Asplenia (HP:0001746)1.58156084
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.57104371
78Fibular hypoplasia (HP:0003038)1.56653849
79Renal salt wasting (HP:0000127)1.52896564
80Absent frontal sinuses (HP:0002688)1.50532995
81Microglossia (HP:0000171)1.49124768
82Tongue fasciculations (HP:0001308)1.48834843
83Preaxial hand polydactyly (HP:0001177)1.47073825
84Amyotrophic lateral sclerosis (HP:0007354)1.46990538
85Impaired smooth pursuit (HP:0007772)1.46342269
86Renal dysplasia (HP:0000110)1.45233953
87Hyperkalemia (HP:0002153)1.42511722
88Cystic liver disease (HP:0006706)1.39607077
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.38972059
90Retinal dysplasia (HP:0007973)1.38940825
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.38116669
92Deformed sella turcica (HP:0002681)1.37380085
93Supernumerary spleens (HP:0009799)1.37083136
94Muscle fibrillation (HP:0010546)1.36555667
95Abnormality of the dental root (HP:0006486)1.36512892
96Taurodontia (HP:0000679)1.36512892
97Abnormality of permanent molar morphology (HP:0011071)1.36512892
98Bell-shaped thorax (HP:0001591)1.36175920
99Bundle branch block (HP:0011710)1.36009933
100Bile duct proliferation (HP:0001408)1.35535634
101Abnormal biliary tract physiology (HP:0012439)1.35535634
102Median cleft lip (HP:0000161)1.35366644
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.35265663
104Absent epiphyses (HP:0010577)1.34399523
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.34399523
106Cerebellar dysplasia (HP:0007033)1.34292744
107Abnormal urine output (HP:0012590)1.32420347
108Hemiparesis (HP:0001269)1.31872615
109Easy fatigability (HP:0003388)1.31754793
110Type II lissencephaly (HP:0007260)1.31725068
111Hyperaldosteronism (HP:0000859)1.31599495
112Neurofibrillary tangles (HP:0002185)1.30134961
113Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29641930
114Abnormality of dentin (HP:0010299)1.27983891
115Pachygyria (HP:0001302)1.27565583
116Abnormality of molar (HP:0011077)1.26540365
117Abnormality of molar morphology (HP:0011070)1.26540365
118Short thorax (HP:0010306)1.25841363
119Nephropathy (HP:0000112)1.24945124
120Short nail (HP:0001799)1.24787321
121Abnormality of the dental pulp (HP:0006479)1.24704831
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.24153919
123Abnormality of renin-angiotensin system (HP:0000847)1.18988684
124Abnormality of chloride homeostasis (HP:0011422)1.17955792
125Bifid scrotum (HP:0000048)1.15738994
126Broad distal phalanx of finger (HP:0009836)1.14025917
127Abnormality of the frontal sinuses (HP:0002687)1.08227906
128Cone-rod dystrophy (HP:0000548)1.07924595
129Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.07552750
130Hypokalemic alkalosis (HP:0001949)1.07087506
131Narrow forehead (HP:0000341)1.03550498
132Prominent nasal bridge (HP:0000426)1.01866033
133Retinitis pigmentosa (HP:0000510)1.00625594
134Fetal akinesia sequence (HP:0001989)0.99137657
135Multicystic kidney dysplasia (HP:0000003)0.97657802
136Abnormality of the distal phalanges of the toes (HP:0010182)0.97499982
137Aganglionic megacolon (HP:0002251)0.97171301
138Abnormal rod and cone electroretinograms (HP:0008323)0.95610281
139Hand muscle atrophy (HP:0009130)0.95259803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.34378309
2PDK48.34378309
3TESK15.77618168
4PDK25.34721017
5MST45.08953263
6PRKD34.79993311
7EPHA23.89299696
8ICK3.88008127
9PTK2B2.75192121
10CDK192.40680956
11WNK42.24062774
12STK392.16479298
13PNCK2.12513365
14MAP3K22.07903081
15STK381.97746909
16MAPKAPK31.83350589
17STK241.69399694
18NME11.67817287
19BCR1.62044157
20NEK21.52824214
21CSK1.28214656
22PDK11.22682896
23SMG11.22333268
24DYRK1B1.22154770
25RIPK41.18882304
26TLK11.18211014
27TSSK61.16236204
28EPHA31.13378702
29CCNB11.10673781
30MAP3K31.02129938
31TYRO30.96134948
32LRRK20.94373076
33EPHB10.86769532
34PRKCI0.86127721
35STK100.85182780
36MST1R0.83245501
37WNK10.79505050
38MAP3K70.79339072
39TRPM70.78561530
40ERBB20.78083268
41MAP4K20.75094840
42MET0.74885036
43EEF2K0.74342572
44LMTK20.74199219
45PDPK10.72219211
46DYRK30.70571301
47STK38L0.64251197
48IRAK10.59742543
49MAPK150.59279667
50CHEK20.58190849
51STK30.58021208
52MAP2K70.56356195
53ERBB30.55236314
54PASK0.54014887
55NLK0.53240487
56TESK20.49377365
57CAMK1G0.49343439
58STK160.48170946
59PINK10.47970123
60PRKCG0.47726915
61AURKA0.47697154
62MAP2K60.47331748
63SGK10.47080648
64MAP3K40.43704057
65PLK40.42194481
66WEE10.41505252
67TTK0.40440539
68TBK10.40378488
69CDK120.38288835
70CAMKK10.37327255
71NEK90.37298533
72NTRK20.36925173
73CDK30.36212282
74AKT20.35525127
75PRKCD0.34990634
76LATS10.34338366
77CAMK2G0.32809872
78MAPK130.32709344
79INSRR0.32664061
80CHEK10.32644901
81RET0.32264433
82FGFR30.30793121
83DYRK1A0.30564671
84PAK10.30443216
85MAP3K120.30318477
86NEK60.30096520
87PTK60.29865966
88ROCK10.28390940
89BRSK20.27713055
90MUSK0.27353944
91HIPK20.26634259
92SGK2230.26421391
93SGK4940.26421391
94EPHA40.25081103
95FER0.24989646
96DAPK20.24766665
97PLK20.24414462
98MAP2K20.24302968
99PRKAA20.23398534
100BRSK10.23035285
101RIPK10.22931125
102MAPKAPK50.22924777
103ATM0.22758357
104ATR0.22553493
105MAP3K90.22458989
106RPS6KB20.21237669
107OXSR10.21090367
108SGK20.20922595
109PRKACA0.20441224
110MARK20.19846376
111ROCK20.19777544
112EGFR0.19750680
113IRAK20.19676257
114ADRBK10.18425520
115RPS6KB10.17966847
116ABL10.17667645
117MTOR0.16664708
118MINK10.16590597
119NTRK30.16396786
120ADRBK20.16178915
121PRKCQ0.15632972
122CDK150.15256222
123CHUK0.15045235
124CDK60.14624319
125MAP2K10.14326480
126FGR0.14257275
127PRKDC0.14236359
128CAMK2A0.14088326
129KSR20.13797493
130PRKAA10.13434992
131CDK180.12885458
132PLK10.12625819
133PRKG20.12439872
134PAK60.11815922
135PRKCZ0.11787657
136ACVR1B0.11417348
137CDK11A0.11371522
138PAK20.11316535
139PRKG10.11226911
140GRK10.11174684
141BRAF0.11066503
142CDK140.09523246
143CSF1R0.08635027
144STK110.08414449
145PKN10.08059941
146MARK30.07919596
147CDC70.07848607
148PAK40.07835586
149DAPK10.07772446
150PDGFRB0.06116954
151MAP3K10.05409233
152GRK50.05062107
153GSK3B0.04434649
154PRKCA0.03337034
155YES10.02911969
156ZAP700.02574433
157PRKACG0.02528056
158MAPK80.02140016
159CDK50.02127925
160CSNK2A10.02013632
161CSNK2A20.01717933
162PRKCB0.01125483
163RPS6KA30.00526699
164MAP3K100.00410768
165MAP2K40.00242633
166RPS6KA10.00107890
167WNK3-0.0003829

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.90409800
2Histidine metabolism_Homo sapiens_hsa003404.44794659
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.07575781
4Fatty acid biosynthesis_Homo sapiens_hsa000613.81075196
5Tyrosine metabolism_Homo sapiens_hsa003503.78054278
6Pyruvate metabolism_Homo sapiens_hsa006203.53338965
7Vitamin B6 metabolism_Homo sapiens_hsa007503.42074782
8beta-Alanine metabolism_Homo sapiens_hsa004103.15298480
9Propanoate metabolism_Homo sapiens_hsa006402.74244587
10Glucagon signaling pathway_Homo sapiens_hsa049222.68126815
11Basal transcription factors_Homo sapiens_hsa030222.41832444
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40844057
13Linoleic acid metabolism_Homo sapiens_hsa005912.33572559
14Retinol metabolism_Homo sapiens_hsa008302.33561674
15Caffeine metabolism_Homo sapiens_hsa002322.26194552
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24133345
17Pentose phosphate pathway_Homo sapiens_hsa000302.10759094
18Amphetamine addiction_Homo sapiens_hsa050312.08883035
19Carbohydrate digestion and absorption_Homo sapiens_hsa049732.05273936
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.94493162
21Oocyte meiosis_Homo sapiens_hsa041141.93461598
22Glycerolipid metabolism_Homo sapiens_hsa005611.84537265
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82088860
24Selenocompound metabolism_Homo sapiens_hsa004501.73521308
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69985617
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69930700
27Collecting duct acid secretion_Homo sapiens_hsa049661.68573601
28PPAR signaling pathway_Homo sapiens_hsa033201.66274547
29Dorso-ventral axis formation_Homo sapiens_hsa043201.63635293
30Synaptic vesicle cycle_Homo sapiens_hsa047211.63392453
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.63119655
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63106966
33Cardiac muscle contraction_Homo sapiens_hsa042601.62664526
34Huntingtons disease_Homo sapiens_hsa050161.60400395
35Fructose and mannose metabolism_Homo sapiens_hsa000511.59408127
36Renin secretion_Homo sapiens_hsa049241.57205912
37Sphingolipid metabolism_Homo sapiens_hsa006001.53919736
38Fanconi anemia pathway_Homo sapiens_hsa034601.45772288
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.42246041
40Long-term potentiation_Homo sapiens_hsa047201.41639431
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.38605557
42Tight junction_Homo sapiens_hsa045301.38426443
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35564958
44Carbon metabolism_Homo sapiens_hsa012001.33288713
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28787788
46Mineral absorption_Homo sapiens_hsa049781.27751647
47Peroxisome_Homo sapiens_hsa041461.25359319
48Insulin secretion_Homo sapiens_hsa049111.25073967
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17082701
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12858910
51Circadian rhythm_Homo sapiens_hsa047101.12339690
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.09984529
53Calcium signaling pathway_Homo sapiens_hsa040201.05201566
54Fat digestion and absorption_Homo sapiens_hsa049751.04874723
55Ether lipid metabolism_Homo sapiens_hsa005651.03315584
56Notch signaling pathway_Homo sapiens_hsa043300.95227849
57Fatty acid metabolism_Homo sapiens_hsa012120.92541275
58Phototransduction_Homo sapiens_hsa047440.92208896
59Circadian entrainment_Homo sapiens_hsa047130.90528155
60Purine metabolism_Homo sapiens_hsa002300.89775599
61Renin-angiotensin system_Homo sapiens_hsa046140.86232849
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86037915
63Biosynthesis of amino acids_Homo sapiens_hsa012300.85690136
64Salivary secretion_Homo sapiens_hsa049700.85270626
65Starch and sucrose metabolism_Homo sapiens_hsa005000.85207687
66Fatty acid degradation_Homo sapiens_hsa000710.84078323
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84058379
68Estrogen signaling pathway_Homo sapiens_hsa049150.83165106
69Taste transduction_Homo sapiens_hsa047420.81880046
70Basal cell carcinoma_Homo sapiens_hsa052170.81699253
71Gastric acid secretion_Homo sapiens_hsa049710.80068293
72mRNA surveillance pathway_Homo sapiens_hsa030150.80045740
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79293085
74Choline metabolism in cancer_Homo sapiens_hsa052310.75453873
75Thyroid hormone synthesis_Homo sapiens_hsa049180.75218958
76Antigen processing and presentation_Homo sapiens_hsa046120.74444527
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73223897
78Olfactory transduction_Homo sapiens_hsa047400.71636377
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.71606254
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69187629
81Glutathione metabolism_Homo sapiens_hsa004800.69171578
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66414428
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66039112
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64746898
85Glutamatergic synapse_Homo sapiens_hsa047240.62971767
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62866287
87Inositol phosphate metabolism_Homo sapiens_hsa005620.62733809
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62695358
89Pancreatic secretion_Homo sapiens_hsa049720.62252559
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.61833853
91Nicotine addiction_Homo sapiens_hsa050330.61647270
92RNA transport_Homo sapiens_hsa030130.60952530
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.60927647
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.60560727
95Systemic lupus erythematosus_Homo sapiens_hsa053220.60256007
96Adherens junction_Homo sapiens_hsa045200.60068153
97Hedgehog signaling pathway_Homo sapiens_hsa043400.59736945
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59143206
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58015533
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57638800
101N-Glycan biosynthesis_Homo sapiens_hsa005100.53721693
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52603990
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.51878558
104Bile secretion_Homo sapiens_hsa049760.51239350
105cAMP signaling pathway_Homo sapiens_hsa040240.50870442
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.50868197
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49460744
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48710188
109Chemical carcinogenesis_Homo sapiens_hsa052040.47568723
110Dopaminergic synapse_Homo sapiens_hsa047280.47213431
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46212130
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.45818156
113Cocaine addiction_Homo sapiens_hsa050300.45560415
114Hepatitis C_Homo sapiens_hsa051600.45408207
115Endocytosis_Homo sapiens_hsa041440.44860912
116AMPK signaling pathway_Homo sapiens_hsa041520.44468448
117Hippo signaling pathway_Homo sapiens_hsa043900.43761322
118VEGF signaling pathway_Homo sapiens_hsa043700.43700747
119Arachidonic acid metabolism_Homo sapiens_hsa005900.42800793
120Vibrio cholerae infection_Homo sapiens_hsa051100.40905679
121Oxytocin signaling pathway_Homo sapiens_hsa049210.37104936
122Protein digestion and absorption_Homo sapiens_hsa049740.36516401
123Alcoholism_Homo sapiens_hsa050340.36056399
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35166401
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35052839
126Arginine and proline metabolism_Homo sapiens_hsa003300.34562522
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34199017
128Metabolic pathways_Homo sapiens_hsa011000.33935339
129Butanoate metabolism_Homo sapiens_hsa006500.31559990
130ABC transporters_Homo sapiens_hsa020100.29866834
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29436825
132Morphine addiction_Homo sapiens_hsa050320.28337477
133Complement and coagulation cascades_Homo sapiens_hsa046100.28101882
134Type II diabetes mellitus_Homo sapiens_hsa049300.27742417
135Ovarian steroidogenesis_Homo sapiens_hsa049130.27611621
136Serotonergic synapse_Homo sapiens_hsa047260.27573451
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26688987
138Tryptophan metabolism_Homo sapiens_hsa003800.25008394
139Legionellosis_Homo sapiens_hsa051340.24732014
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21769142
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21456206
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21427088
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20831263
144Regulation of autophagy_Homo sapiens_hsa041400.20779745
145Melanogenesis_Homo sapiens_hsa049160.19493906
146Vitamin digestion and absorption_Homo sapiens_hsa049770.18359046
147Axon guidance_Homo sapiens_hsa043600.17444404
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16885269
149Wnt signaling pathway_Homo sapiens_hsa043100.15335314
150Nitrogen metabolism_Homo sapiens_hsa009100.14558035
151Hematopoietic cell lineage_Homo sapiens_hsa046400.13883980
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12377050
153Amoebiasis_Homo sapiens_hsa051460.11745010
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.11736562
155Nucleotide excision repair_Homo sapiens_hsa034200.10962599
156Lysosome_Homo sapiens_hsa041420.08732102
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.08451827
158Prostate cancer_Homo sapiens_hsa052150.07169392
159Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06128258

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