SPAG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.68217565
2binding of sperm to zona pellucida (GO:0007339)9.65128795
3cilium or flagellum-dependent cell motility (GO:0001539)9.46505748
4epithelial cilium movement (GO:0003351)9.28439346
5axonemal dynein complex assembly (GO:0070286)9.06434867
6motile cilium assembly (GO:0044458)8.98613771
7plasma membrane fusion (GO:0045026)8.84464476
8reproduction (GO:0000003)8.72559660
9spermatid development (GO:0007286)8.53803624
10regulation of cilium movement (GO:0003352)8.08748399
11cilium movement (GO:0003341)7.56449040
12single fertilization (GO:0007338)6.92049093
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.90931285
14sperm capacitation (GO:0048240)6.85216862
15male meiosis (GO:0007140)6.78378569
16microtubule depolymerization (GO:0007019)6.71539431
17piRNA metabolic process (GO:0034587)6.46880543
18synaptonemal complex organization (GO:0070193)6.35650624
19synaptonemal complex assembly (GO:0007130)6.26026129
20* spermatogenesis (GO:0007283)5.89121435
21* male gamete generation (GO:0048232)5.87835857
22organic cation transport (GO:0015695)5.63158898
23fertilization (GO:0009566)5.61239781
24* gamete generation (GO:0007276)5.40013300
25rRNA methylation (GO:0031167)5.33201717
26ventricular system development (GO:0021591)4.91219129
27protein carboxylation (GO:0018214)4.87648715
28peptidyl-glutamic acid carboxylation (GO:0017187)4.87648715
29negative regulation of inclusion body assembly (GO:0090084)4.86906869
30calcium ion-dependent exocytosis (GO:0017156)4.86805688
31chromosome organization involved in meiosis (GO:0070192)4.86666884
32spermatid nucleus differentiation (GO:0007289)4.86019948
33response to pheromone (GO:0019236)4.83816826
34intestinal cholesterol absorption (GO:0030299)4.80366874
35cellular process involved in reproduction in multicellular organism (GO:0022412)4.78734700
36peptidyl-proline hydroxylation (GO:0019511)4.76330086
37germ cell development (GO:0007281)4.74226249
384-hydroxyproline metabolic process (GO:0019471)4.67084210
39rRNA modification (GO:0000154)4.64396393
40phosphatidylethanolamine biosynthetic process (GO:0006646)4.63484681
41cell recognition (GO:0008037)4.60802992
42regulation of inclusion body assembly (GO:0090083)4.47607581
43male meiosis I (GO:0007141)4.37608935
44protein hydroxylation (GO:0018126)4.33737842
45microtubule severing (GO:0051013)4.33069442
46phosphatidylethanolamine metabolic process (GO:0046337)4.32284389
47DNA methylation involved in gamete generation (GO:0043046)4.31293604
48cellular ketone body metabolic process (GO:0046950)4.29194699
49L-phenylalanine metabolic process (GO:0006558)4.20419255
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.20419255
51* multicellular organismal reproductive process (GO:0048609)4.18254521
52regulation of microtubule-based movement (GO:0060632)4.12739162
53DNA packaging (GO:0006323)4.11991532
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.11694832
55L-phenylalanine catabolic process (GO:0006559)4.11694832
56chromosome condensation (GO:0030261)4.09428327
57meiotic nuclear division (GO:0007126)4.06054507
58sequestering of actin monomers (GO:0042989)4.04816539
59single strand break repair (GO:0000012)4.00179306
60nephron tubule morphogenesis (GO:0072078)3.87349811
61nephron epithelium morphogenesis (GO:0072088)3.87349811
62glycerol ether metabolic process (GO:0006662)3.83856296
63centriole assembly (GO:0098534)3.81461867
64monoubiquitinated protein deubiquitination (GO:0035520)3.79991363
65GDP-mannose metabolic process (GO:0019673)3.75884459
66ketone body metabolic process (GO:1902224)3.74599545
67peptidyl-glutamic acid modification (GO:0018200)3.67305549
68synapsis (GO:0007129)3.64985019
69protein polyglutamylation (GO:0018095)3.60316212
70left/right pattern formation (GO:0060972)3.55527892
71ether metabolic process (GO:0018904)3.55023513
72microtubule polymerization or depolymerization (GO:0031109)3.46776117
73multicellular organismal development (GO:0007275)3.43846367
74meiotic cell cycle (GO:0051321)3.41994418
75meiosis I (GO:0007127)3.41154030
76regulation of spindle checkpoint (GO:0090231)3.37248462
77protein localization to cilium (GO:0061512)3.31643236
78transepithelial transport (GO:0070633)3.31093347
79seminiferous tubule development (GO:0072520)3.27390953
80coenzyme catabolic process (GO:0009109)3.24961487
81cilium organization (GO:0044782)3.23067451
82positive regulation of macrophage activation (GO:0043032)3.22720036
83protein localization to Golgi apparatus (GO:0034067)3.22703092
84protein K11-linked deubiquitination (GO:0035871)3.17821148
85cilium assembly (GO:0042384)3.16357926
86cellular zinc ion homeostasis (GO:0006882)3.14289036
87very-low-density lipoprotein particle assembly (GO:0034379)3.11338686
88meiotic cell cycle process (GO:1903046)3.01118187
89intraciliary transport (GO:0042073)3.00555904
90mesenchymal cell differentiation involved in kidney development (GO:0072161)2.97867326
91mesenchymal cell differentiation involved in renal system development (GO:2001012)2.97867326
92nucleotide-sugar biosynthetic process (GO:0009226)2.97003559
93protein targeting to Golgi (GO:0000042)2.96094780
94glycolytic process (GO:0006096)2.95048889
95plasma lipoprotein particle assembly (GO:0034377)2.94516573
96nucleus organization (GO:0006997)2.94258985
97chaperone-mediated protein complex assembly (GO:0051131)2.92183094
98negative regulation of protein activation cascade (GO:2000258)2.89010642
99centriole replication (GO:0007099)2.88713620
100regulation of cholesterol homeostasis (GO:2000188)2.87186742
101histone exchange (GO:0043486)2.86908418
102proline biosynthetic process (GO:0006561)2.82884250
103protein refolding (GO:0042026)2.79820636
104protein retention in ER lumen (GO:0006621)2.79600495
105cellular component assembly involved in morphogenesis (GO:0010927)2.78710792
106regulation of complement activation (GO:0030449)2.78316380
107negative regulation of Rho protein signal transduction (GO:0035024)2.78313739
108detection of light stimulus involved in visual perception (GO:0050908)2.78132650
109detection of light stimulus involved in sensory perception (GO:0050962)2.78132650
110establishment of protein localization to Golgi (GO:0072600)2.78025022
111negative regulation of complement activation (GO:0045916)2.77454079
112NAD biosynthetic process (GO:0009435)2.76054910
113DNA deamination (GO:0045006)2.75277157
114pattern specification involved in kidney development (GO:0061004)2.74112559
115high-density lipoprotein particle remodeling (GO:0034375)2.73681012
116regulation of protein activation cascade (GO:2000257)2.73319579
117estrogen biosynthetic process (GO:0006703)2.71917910
118cholesterol efflux (GO:0033344)2.71877389
119reverse cholesterol transport (GO:0043691)2.71353370
120maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71023323
121RNA localization (GO:0006403)2.70869437
122GTP biosynthetic process (GO:0006183)2.70748131
123nephron tubule formation (GO:0072079)2.70261586
124negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.70072578
125COPII vesicle coating (GO:0048208)2.69910792
126mannosylation (GO:0097502)2.68798817
127negative regulation of metanephros development (GO:0072217)2.67859080
128retrograde transport, vesicle recycling within Golgi (GO:0000301)2.67138204
129regulation of type B pancreatic cell apoptotic process (GO:2000674)2.66434777
130glomerular visceral epithelial cell development (GO:0072015)2.66052991
131proline metabolic process (GO:0006560)2.65805181
132intestinal absorption (GO:0050892)2.64864076
133cilium morphogenesis (GO:0060271)2.64597995
134genitalia morphogenesis (GO:0035112)2.64361706
135negative regulation of fibrinolysis (GO:0051918)2.60340409
136polyamine biosynthetic process (GO:0006596)2.58937256
137protein K6-linked ubiquitination (GO:0085020)2.55665772
138regulation of centriole replication (GO:0046599)2.54738469
139RNA destabilization (GO:0050779)2.54642959
140positive regulation of mitochondrial fission (GO:0090141)2.54618794
141regulation of fibrinolysis (GO:0051917)2.54508747
142nucleoside diphosphate phosphorylation (GO:0006165)2.53462719
143zinc ion transmembrane transport (GO:0071577)2.53109668
144inner ear receptor cell differentiation (GO:0060113)2.52402474
145sexual reproduction (GO:0019953)2.50546747
146zinc ion homeostasis (GO:0055069)2.50258730
147regulation of acrosome reaction (GO:0060046)2.50078827
148lactate metabolic process (GO:0006089)2.49779549
149mitotic sister chromatid cohesion (GO:0007064)2.49477520
150renal tubule morphogenesis (GO:0061333)2.49262003
151regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.48871852
152arginine metabolic process (GO:0006525)2.48697086
153aromatic amino acid family catabolic process (GO:0009074)2.48391142
154pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.45021432
155microtubule-based movement (GO:0007018)2.44322427
156left/right axis specification (GO:0070986)2.43641612
157interferon-gamma secretion (GO:0072643)2.40088686
158axoneme assembly (GO:0035082)2.38462938
159reciprocal meiotic recombination (GO:0007131)2.34793271
160reciprocal DNA recombination (GO:0035825)2.34793271
161protein localization to chromosome, centromeric region (GO:0071459)2.34651859
162UTP biosynthetic process (GO:0006228)2.33122439
163negative regulation of skeletal muscle tissue development (GO:0048642)2.32769202
164sperm motility (GO:0030317)12.3153373
165cell wall macromolecule catabolic process (GO:0016998)11.9517108
166cell wall macromolecule metabolic process (GO:0044036)11.9517108
167fusion of sperm to egg plasma membrane (GO:0007342)11.5230721
168acrosome reaction (GO:0007340)11.1574557
169sperm-egg recognition (GO:0035036)10.8527349
170acrosome assembly (GO:0001675)10.5314887
171multicellular organism reproduction (GO:0032504)10.5027763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.55386313
2* HIF1A_21447827_ChIP-Seq_MCF-7_Human5.12581839
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.85073357
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.26115372
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.48232476
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.30721730
7EZH2_22144423_ChIP-Seq_EOC_Human3.16820702
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95360904
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81551452
10DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.71907182
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.70202542
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.59993935
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.51455513
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.34106610
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.32633781
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31256958
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22038246
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21571341
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21300615
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20771239
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14680185
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.14274355
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.10422481
24VDR_22108803_ChIP-Seq_LS180_Human2.06847751
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03773430
26E2F1_20622854_ChIP-Seq_HELA_Human2.03436689
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.97420604
28ERA_21632823_ChIP-Seq_H3396_Human1.97324725
29* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.95516093
30* P68_20966046_ChIP-Seq_HELA_Human1.91808318
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.90040760
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89140493
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89078981
34BCL6_27268052_Chip-Seq_Bcells_Human1.85930672
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.85313230
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.83158773
37BCOR_27268052_Chip-Seq_Bcells_Human1.82832955
38* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.81703089
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81515188
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.81404699
41EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.81365057
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80741248
43PHF8_20622854_ChIP-Seq_HELA_Human1.76588534
44KAP1_22055183_ChIP-Seq_ESCs_Mouse1.72697298
45* LXR_22292898_ChIP-Seq_THP-1_Human1.72008364
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.71490133
47STAT1_17558387_ChIP-Seq_HELA_Human1.71367623
48RAC3_21632823_ChIP-Seq_H3396_Human1.70758222
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.69491279
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.68042013
51* FOXP1_21924763_ChIP-Seq_HESCs_Human1.66538000
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.65588893
53MYC_19829295_ChIP-Seq_ESCs_Human1.63905565
54NANOG_20526341_ChIP-Seq_ESCs_Human1.63269226
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.61765336
56RARB_24833708_ChIP-Seq_LIVER_Mouse1.60624124
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.60249387
58P53_21459846_ChIP-Seq_SAOS-2_Human1.58424231
59ZNF274_21170338_ChIP-Seq_K562_Hela1.57525395
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57158268
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56622554
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56153306
63RNF2_27304074_Chip-Seq_NSC_Mouse1.54998075
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53763983
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.52574233
66CTCF_20526341_ChIP-Seq_ESCs_Human1.52020992
67TP53_22127205_ChIP-Seq_IMR90_Human1.51277366
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.49612160
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.49430587
70P53_22387025_ChIP-Seq_ESCs_Mouse1.49031534
71CTCF_27219007_Chip-Seq_Bcells_Human1.48759106
72* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47116388
73OCT4_18555785_Chip-Seq_ESCs_Mouse1.45303468
74ATF3_27146783_Chip-Seq_COLON_Human1.44164458
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.43680995
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42375565
77OCT4_20526341_ChIP-Seq_ESCs_Human1.42262082
78GATA3_21867929_ChIP-Seq_CD8_Mouse1.42082404
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.41631858
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.40626418
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38960358
82KDM2B_26808549_Chip-Seq_REH_Human1.38938110
83P300_18555785_Chip-Seq_ESCs_Mouse1.38194075
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37929011
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37896485
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37456958
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37303587
88TAF2_19829295_ChIP-Seq_ESCs_Human1.37172268
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36544456
90* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.36533413
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36278185
92* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.35784542
93P300_27268052_Chip-Seq_Bcells_Human1.35395325
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.35063732
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34285239
96HNF4A_19822575_ChIP-Seq_HepG2_Human1.34189806
97GATA6_25053715_ChIP-Seq_YYC3_Human1.34067567
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.33022438
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32144377
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.31795120
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30831218
102GATA4_25053715_ChIP-Seq_YYC3_Human1.30133953
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29459725
104SMC4_20622854_ChIP-Seq_HELA_Human1.29243856
105SOX2_22085726_ChIP-Seq_NPCs_Mouse1.28410816
106NMYC_18555785_Chip-Seq_ESCs_Mouse1.27188859
107* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26686928
108P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26592123
109* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.26269328
110ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26101060
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.26072740
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25961798
113HOXB7_26014856_ChIP-Seq_BT474_Human1.25838398
114GABP_17652178_ChIP-ChIP_JURKAT_Human1.25505319
115TET1_21451524_ChIP-Seq_MESCs_Mouse1.25310309
116PU1_27457419_Chip-Seq_LIVER_Mouse1.25288321
117NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24979820
118TP63_22573176_ChIP-Seq_HFKS_Human1.24283037
119GABP_19822575_ChIP-Seq_HepG2_Human1.23748879
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23667481
121GATA3_21867929_ChIP-Seq_TH1_Mouse1.23577454
122CBP_20019798_ChIP-Seq_JUKART_Human1.23536063
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23536063
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.22993545
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22987647
126RACK7_27058665_Chip-Seq_MCF-7_Human1.22631180
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21315881
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.21193450
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20975498
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20099251
131TAF15_26573619_Chip-Seq_HEK293_Human1.19249663
132KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19127554
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18177178
134WDR5_24793694_ChIP-Seq_LNCAP_Human1.18128410
135CTCF_18555785_Chip-Seq_ESCs_Mouse1.17834792
136SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16168033
137ZFX_18555785_Chip-Seq_ESCs_Mouse1.16069996
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15584066
139RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14675794
140GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.14594270
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.14138548
142FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13599690
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13166630
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12190398
145MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10820464
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09879808
147SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09561732
148* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09191169
149PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08378262
150FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08033258
151FLI1_21867929_ChIP-Seq_TH2_Mouse1.07763386
152GF1_26923725_Chip-Seq_HPCs_Mouse1.07697091
153* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07140470
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06156132
155CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06141856
156ERG_20517297_ChIP-Seq_VCAP_Human1.06025071
157FOXM1_23109430_ChIP-Seq_U2OS_Human1.05599355
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05548838
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05548838
160P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04847764
161ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04497882
162FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03036796
163FUS_26573619_Chip-Seq_HEK293_Human1.02304767
164ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01845647
165E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01006065
166SOX9_26525672_Chip-Seq_HEART_Mouse1.00891712
167LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.00639991
168REST_21632747_ChIP-Seq_MESCs_Mouse0.99986222
169BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98580405
170CTCF_21964334_Chip-Seq_Bcells_Human0.96596682
171HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96549974
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95244071
173SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94837701
174ETS1_20019798_ChIP-Seq_JURKAT_Human0.94316859
175SOX2_21211035_ChIP-Seq_LN229_Human0.94303990
176* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93742054
177LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93599429
178TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93582381
179PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93042039
180* FOXH1_21741376_ChIP-Seq_ESCs_Human0.93011186
181MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92631877
182SA1_27219007_Chip-Seq_Bcells_Human0.92031133
183CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90917069
184E2F7_22180533_ChIP-Seq_HELA_Human0.90020134
185RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88704388
186RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88294865
187KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87898538
188* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87506245
189PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85946453
190RARA_24833708_ChIP-Seq_LIVER_Mouse0.84901103
191SPI1_26923725_Chip-Seq_HPCs_Mouse0.84737748
192* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82932577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.30517421
2MP0001929_abnormal_gametogenesis4.82011597
3MP0003195_calcinosis4.24065715
4MP0008877_abnormal_DNA_methylation4.23328301
5MP0008875_abnormal_xenobiotic_pharmacok3.67576893
6MP0002210_abnormal_sex_determination3.34336575
7MP0005365_abnormal_bile_salt3.04214252
8MP0005360_urolithiasis3.02437317
9MP0002139_abnormal_hepatobiliary_system2.94527554
10MP0002161_abnormal_fertility/fecundity2.84568376
11MP0001145_abnormal_male_reproductive2.72089753
12MP0009780_abnormal_chondrocyte_physiolo2.63794219
13MP0003122_maternal_imprinting2.62986354
14MP0008058_abnormal_DNA_repair2.57406054
15MP0003950_abnormal_plasma_membrane2.49777342
16MP0006054_spinal_hemorrhage2.41056422
17MP0000653_abnormal_sex_gland2.39708265
18MP0002653_abnormal_ependyma_morphology2.28895871
19MP0001666_abnormal_nutrient_absorption2.21860408
20MP0002160_abnormal_reproductive_system2.11564868
21MP0010329_abnormal_lipoprotein_level2.02001155
22MP0005410_abnormal_fertilization13.5603483
23MP0005083_abnormal_biliary_tract1.89218127
24MP0005084_abnormal_gallbladder_morpholo1.85508163
25MP0005332_abnormal_amino_acid1.84807208
26MP0005670_abnormal_white_adipose1.81394398
27MP0003123_paternal_imprinting1.80948937
28MP0003111_abnormal_nucleus_morphology1.79828070
29MP0005379_endocrine/exocrine_gland_phen1.77302094
30MP0005257_abnormal_intraocular_pressure1.74540740
31MP0010094_abnormal_chromosome_stability1.74415390
32MP0000566_synostosis1.66303572
33MP0004272_abnormal_basement_membrane1.66300880
34MP0001756_abnormal_urination1.66242629
35MP0005085_abnormal_gallbladder_physiolo1.64273293
36MP0002138_abnormal_hepatobiliary_system1.60034434
37MP0008995_early_reproductive_senescence1.55794714
38MP0005408_hypopigmentation1.53911309
39MP0005551_abnormal_eye_electrophysiolog1.53096126
40MP0003646_muscle_fatigue1.51728953
41MP0003786_premature_aging1.50948428
42MP0001348_abnormal_lacrimal_gland1.49475117
43MP0000003_abnormal_adipose_tissue1.49282190
44MP0003718_maternal_effect1.47299713
45MP0002132_abnormal_respiratory_system1.46628318
46MP0000678_abnormal_parathyroid_gland1.42465699
47MP0009046_muscle_twitch1.39956859
48MP0004019_abnormal_vitamin_homeostasis1.39807313
49MP0009697_abnormal_copulation1.38675667
50MP0002102_abnormal_ear_morphology1.36587154
51MP0008007_abnormal_cellular_replicative1.35667199
52MP0001984_abnormal_olfaction1.33628040
53MP0003172_abnormal_lysosome_physiology1.31526668
54MP0005623_abnormal_meninges_morphology1.29443627
55MP0000569_abnormal_digit_pigmentation1.29129330
56MP0005389_reproductive_system_phenotype1.28858441
57MP0005220_abnormal_exocrine_pancreas1.25734602
58MP0001661_extended_life_span1.22685540
59MP0005636_abnormal_mineral_homeostasis1.22239304
60MP0002282_abnormal_trachea_morphology1.21448441
61MP0005647_abnormal_sex_gland1.21301681
62MP0010234_abnormal_vibrissa_follicle1.19431864
63MP0000639_abnormal_adrenal_gland1.18775271
64MP0008057_abnormal_DNA_replication1.18156766
65MP0000013_abnormal_adipose_tissue1.17696294
66MP0003252_abnormal_bile_duct1.16449046
67MP0009643_abnormal_urine_homeostasis1.10861756
68MP0005451_abnormal_body_composition1.09894814
69MP0001835_abnormal_antigen_presentation1.08126862
70MP0002118_abnormal_lipid_homeostasis1.04841331
71MP0000609_abnormal_liver_physiology1.02219161
72MP0002234_abnormal_pharynx_morphology1.01014851
73MP0005395_other_phenotype1.00688463
74MP0010386_abnormal_urinary_bladder0.99254192
75MP0008775_abnormal_heart_ventricle0.98626729
76MP0002909_abnormal_adrenal_gland0.98330217
77MP0009840_abnormal_foam_cell0.98254547
78MP0002938_white_spotting0.97956280
79MP0001119_abnormal_female_reproductive0.96773478
80MP0000015_abnormal_ear_pigmentation0.95900578
81MP0002933_joint_inflammation0.95605477
82MP0002163_abnormal_gland_morphology0.95225169
83MP0003693_abnormal_embryo_hatching0.93783767
84MP0000372_irregular_coat_pigmentation0.90932355
85MP0005646_abnormal_pituitary_gland0.88839595
86MP0001944_abnormal_pancreas_morphology0.88024361
87MP0000613_abnormal_salivary_gland0.87622399
88MP0003077_abnormal_cell_cycle0.87354782
89MP0006292_abnormal_olfactory_placode0.87145515
90MP0001188_hyperpigmentation0.84186746
91MP0002693_abnormal_pancreas_physiology0.83362961
92MP0003121_genomic_imprinting0.82491331
93MP0002009_preneoplasia0.82121124
94MP0005367_renal/urinary_system_phenotyp0.80547879
95MP0000516_abnormal_urinary_system0.80547879
96MP0001324_abnormal_eye_pigmentation0.80445787
97MP0000538_abnormal_urinary_bladder0.78822337
98MP0003787_abnormal_imprinting0.77694581
99MP0005330_cardiomyopathy0.77647860
100MP0001919_abnormal_reproductive_system0.77390036
101MP0002136_abnormal_kidney_physiology0.76269201
102MP0010030_abnormal_orbit_morphology0.75222706
103MP0009384_cardiac_valve_regurgitation0.73897961
104MP0003878_abnormal_ear_physiology0.71027620
105MP0005377_hearing/vestibular/ear_phenot0.71027620
106MP0004264_abnormal_extraembryonic_tissu0.70919156
107MP0003011_delayed_dark_adaptation0.70686533
108MP0004484_altered_response_of0.68943351
109MP0003136_yellow_coat_color0.68245060
110MP0008438_abnormal_cutaneous_collagen0.67549861
111MP0002168_other_aberrant_phenotype0.67506440
112MP0002254_reproductive_system_inflammat0.66334775
113MP0003656_abnormal_erythrocyte_physiolo0.66332661
114MP0000681_abnormal_thyroid_gland0.65977418
115MP0001293_anophthalmia0.65789944
116MP0004233_abnormal_muscle_weight0.64851653
117MP0002089_abnormal_postnatal_growth/wei0.64213277
118MP0001764_abnormal_homeostasis0.63642048
119MP0000049_abnormal_middle_ear0.63561316
120MP0004742_abnormal_vestibular_system0.63212125
121MP0008789_abnormal_olfactory_epithelium0.62392513
122MP0002078_abnormal_glucose_homeostasis0.61679779
123MP0005171_absent_coat_pigmentation0.61642768
124MP0003953_abnormal_hormone_level0.61258496
125MP0002405_respiratory_system_inflammati0.61021782
126MP0002736_abnormal_nociception_after0.59218783
127MP0005167_abnormal_blood-brain_barrier0.59098572
128MP0006276_abnormal_autonomic_nervous0.57293002
129MP0003699_abnormal_female_reproductive0.56794825
130MP0002148_abnormal_hypersensitivity_rea0.56278708
131MP0003315_abnormal_perineum_morphology0.56246269
132MP0005645_abnormal_hypothalamus_physiol0.56215101
133MP0009785_altered_susceptibility_to0.55161087
134MP0002928_abnormal_bile_duct0.54776135
135MP0001986_abnormal_taste_sensitivity0.54266335
136MP0005499_abnormal_olfactory_system0.53603221
137MP0005394_taste/olfaction_phenotype0.53603221
138MP0005397_hematopoietic_system_phenotyp0.53516177
139MP0001545_abnormal_hematopoietic_system0.53516177
140MP0003115_abnormal_respiratory_system0.52990318
141MP0001270_distended_abdomen0.51194911
142MP0005423_abnormal_somatic_nervous0.49855868
143MP0003763_abnormal_thymus_physiology0.49064070
144MP0001529_abnormal_vocalization0.47087292
145MP0000026_abnormal_inner_ear0.46635361
146MP0002396_abnormal_hematopoietic_system0.45821509
147MP0001873_stomach_inflammation0.45422637
148MP0002638_abnormal_pupillary_reflex0.44979532
149MP0005174_abnormal_tail_pigmentation0.43954852
150MP0008932_abnormal_embryonic_tissue0.43479022
151MP0005671_abnormal_response_to0.42828546
152MP0004808_abnormal_hematopoietic_stem0.41560521
153MP0005253_abnormal_eye_physiology0.41546496
154MP0002398_abnormal_bone_marrow0.41449023
155MP0000313_abnormal_cell_death0.41161150
156MP0001502_abnormal_circadian_rhythm0.39887603
157MP0004133_heterotaxia0.39862539
158MP0002723_abnormal_immune_serum0.39562443
159MP0003942_abnormal_urinary_system0.39113455
160MP0000358_abnormal_cell_content/0.38633133
161MP0001765_abnormal_ion_homeostasis0.37861884
162MP0005025_abnormal_response_to0.37576747
163MP0002735_abnormal_chemical_nociception0.37025978
164MP0009278_abnormal_bone_marrow0.36415153
165MP0002452_abnormal_antigen_presenting0.35333284
166MP0002876_abnormal_thyroid_physiology0.35049382
167MP0000703_abnormal_thymus_morphology0.34755893
168MP0002277_abnormal_respiratory_mucosa0.34292404
169MP0002419_abnormal_innate_immunity0.32259790
170MP0005391_vision/eye_phenotype0.32225678
171MP0001819_abnormal_immune_cell0.31810391
172MP0002420_abnormal_adaptive_immunity0.31269925

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.95885136
2Abnormal respiratory motile cilium morphology (HP:0005938)7.90503656
3Abnormal respiratory epithelium morphology (HP:0012253)7.90503656
4Abnormal ciliary motility (HP:0012262)6.53713585
5Rhinitis (HP:0012384)6.27866774
6Chronic bronchitis (HP:0004469)5.63187319
7Infertility (HP:0000789)5.44999953
8Nasal polyposis (HP:0100582)5.30814925
9Prolonged partial thromboplastin time (HP:0003645)4.68185049
10Nephronophthisis (HP:0000090)4.38953106
11Attenuation of retinal blood vessels (HP:0007843)4.38804719
12Abnormal spermatogenesis (HP:0008669)4.25497511
13Abnormality of the nasal mucosa (HP:0000433)4.04313609
14Deep venous thrombosis (HP:0002625)3.92752958
15Severe visual impairment (HP:0001141)3.89791189
16Bronchitis (HP:0012387)3.81166502
17Joint hemorrhage (HP:0005261)3.76666582
18Bronchiectasis (HP:0002110)3.73755125
19Abnormal gallbladder physiology (HP:0012438)3.72101477
20Cholecystitis (HP:0001082)3.72101477
21Bony spicule pigmentary retinopathy (HP:0007737)3.53371527
22Male infertility (HP:0003251)3.45772347
23Hypophosphatemic rickets (HP:0004912)3.42049675
24Abnormality of the renal medulla (HP:0100957)3.35210950
25Renal Fanconi syndrome (HP:0001994)3.33665117
26Medial flaring of the eyebrow (HP:0010747)3.22031746
27Recurrent sinusitis (HP:0011108)3.21464959
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.14079473
29Impulsivity (HP:0100710)3.12247948
30Azoospermia (HP:0000027)3.11990930
31Abnormality of the intrinsic pathway (HP:0010989)3.01462521
32Tubulointerstitial nephritis (HP:0001970)3.00889142
33Molar tooth sign on MRI (HP:0002419)2.94370059
34Abnormality of midbrain morphology (HP:0002418)2.94370059
35Recurrent otitis media (HP:0000403)2.93505472
36Small epiphyses (HP:0010585)2.90663161
37Abnormality of the common coagulation pathway (HP:0010990)2.86602540
38Abnormal rod and cone electroretinograms (HP:0008323)2.82494593
39Popliteal pterygium (HP:0009756)2.81565500
40Potter facies (HP:0002009)2.73116772
41Facial shape deformation (HP:0011334)2.73116772
42Testicular atrophy (HP:0000029)2.69245697
43Hemorrhage of the eye (HP:0011885)2.67840897
44Vaginal fistula (HP:0004320)2.62556318
45Recurrent bronchitis (HP:0002837)2.59819290
46Hypercholesterolemia (HP:0003124)2.59289518
47Generalized aminoaciduria (HP:0002909)2.57780289
48Postaxial foot polydactyly (HP:0001830)2.55588913
49Abnormality of urine glucose concentration (HP:0011016)2.54165825
50Glycosuria (HP:0003076)2.54165825
51Tubular atrophy (HP:0000092)2.53897355
52Bile duct proliferation (HP:0001408)2.51829525
53Abnormal biliary tract physiology (HP:0012439)2.51829525
54Pancreatic fibrosis (HP:0100732)2.50671960
55Gonadotropin excess (HP:0000837)2.49669161
56Mesangial abnormality (HP:0001966)2.47702590
57Abnormal urine output (HP:0012590)2.45546788
58Retrobulbar optic neuritis (HP:0100654)2.43027325
59Optic neuritis (HP:0100653)2.43027325
60Pancreatic islet-cell hyperplasia (HP:0004510)2.41215855
61Abnormality of glycolysis (HP:0004366)2.40944304
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40909489
63Increased hepatocellular lipid droplets (HP:0006565)2.39598445
64Tubulointerstitial abnormality (HP:0001969)2.35635747
65Abnormal tarsal ossification (HP:0008369)2.29210222
66Epiphyseal dysplasia (HP:0002656)2.26085296
67Hypobetalipoproteinemia (HP:0003563)2.25350836
68Rectal fistula (HP:0100590)2.25089952
69Rectovaginal fistula (HP:0000143)2.25089952
70Decreased central vision (HP:0007663)2.24872022
71Zonular cataract (HP:0010920)2.23322816
72True hermaphroditism (HP:0010459)2.22379073
73Xanthomatosis (HP:0000991)2.21894381
74Hypolipoproteinemia (HP:0010981)2.21873279
75Chromsome breakage (HP:0040012)2.20809155
76Type I transferrin isoform profile (HP:0003642)2.18553393
77Abnormality of renal excretion (HP:0011036)2.18345857
78Hypoalphalipoproteinemia (HP:0003233)2.13815600
79Congenital hepatic fibrosis (HP:0002612)2.13162955
80Renal dysplasia (HP:0000110)2.12834446
81Congenital stationary night blindness (HP:0007642)2.12580105
82Dyschromatopsia (HP:0007641)2.12550785
83Lipid accumulation in hepatocytes (HP:0006561)2.12125071
84Ketosis (HP:0001946)2.11399883
85Bifid uvula (HP:0000193)2.11395475
86Abnormality of the vitreous humor (HP:0004327)2.06877613
87Reduced antithrombin III activity (HP:0001976)2.06769870
88Congenital primary aphakia (HP:0007707)2.06453382
89Abnormality of dental color (HP:0011073)2.05032655
90Abnormality of the renal cortex (HP:0011035)2.04218077
91Ketoacidosis (HP:0001993)2.03157196
92Optic nerve hypoplasia (HP:0000609)2.02712728
93Gait imbalance (HP:0002141)2.01505747
94Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01118387
95Menorrhagia (HP:0000132)2.00968635
96Polyuria (HP:0000103)2.00697836
97Abnormality of renal resorption (HP:0011038)2.00240389
98Cholelithiasis (HP:0001081)2.00106119
99Abnormal gallbladder morphology (HP:0012437)2.00077585
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6911254
101Dynein arm defect of respiratory motile cilia (HP:0012255)11.3496086
102Absent/shortened dynein arms (HP:0200106)11.3496086
103Abnormality of endocrine pancreas physiology (HP:0012093)1.99226254
104Abnormality of the pancreatic islet cells (HP:0006476)1.99226254
105Facial cleft (HP:0002006)1.98676035
106Nuclear cataract (HP:0100018)1.95675077
107Median cleft lip (HP:0000161)1.94695328
108Flattened epiphyses (HP:0003071)1.94096202
109Hypoalbuminemia (HP:0003073)1.91053131
110Abnormal albumin level (HP:0012116)1.91053131
111Nephrogenic diabetes insipidus (HP:0009806)1.89997686
112Vascular calcification (HP:0004934)1.87935200
113Intestinal fistula (HP:0100819)1.87866653
114Increased serum pyruvate (HP:0003542)1.86411794
115Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84610887
116Abnormality of the femoral head (HP:0003368)1.84569601
117Hyperinsulinemic hypoglycemia (HP:0000825)1.83885621
118Glomerulosclerosis (HP:0000096)1.83739801
119Orchitis (HP:0100796)1.83560379
120Late onset (HP:0003584)1.83197375
121Pancreatic cysts (HP:0001737)1.82983620
122Aplasia/Hypoplasia of the lens (HP:0008063)1.82857111
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.82547566
124Abnormality of macular pigmentation (HP:0008002)1.79518756
125Postaxial hand polydactyly (HP:0001162)1.79445334
126Unilateral renal agenesis (HP:0000122)1.78440569
127Tongue fasciculations (HP:0001308)1.78122276
128Cystic liver disease (HP:0006706)1.77006718
129Pigmentary retinal degeneration (HP:0001146)1.76753491
130Choroideremia (HP:0001139)1.76661245
131Chronic hepatic failure (HP:0100626)1.75952715
132Poikiloderma (HP:0001029)1.75388538
133Hyperphosphaturia (HP:0003109)1.74334993
134Neonatal respiratory distress (HP:0002643)1.73663568
135Abnormality of proline metabolism (HP:0010907)1.73225286
136Hydroxyprolinuria (HP:0003080)1.73225286
137Epiphyseal stippling (HP:0010655)1.72810898
138Broad alveolar ridges (HP:0000187)1.72587397
139Spontaneous abortion (HP:0005268)1.72014654
140Ectopic kidney (HP:0000086)1.71793147
141Abnormal urine phosphate concentration (HP:0012599)1.71087222
142Abnormality of permanent molar morphology (HP:0011071)1.70467027
143Abnormality of the dental root (HP:0006486)1.70467027
144Taurodontia (HP:0000679)1.70467027
145Pterygium (HP:0001059)1.70111523
146Hypoglycemic coma (HP:0001325)1.70077055
147Abnormal drinking behavior (HP:0030082)1.69750939
148Polydipsia (HP:0001959)1.69750939
149Hypothermia (HP:0002045)1.69589524
150Asymmetric septal hypertrophy (HP:0001670)1.69546393
151Preaxial hand polydactyly (HP:0001177)1.69080329
152Abnormality of molar (HP:0011077)1.68276681
153Abnormality of molar morphology (HP:0011070)1.68276681
154Oculomotor apraxia (HP:0000657)1.67383720
155Occipital encephalocele (HP:0002085)1.66781671
156Tubulointerstitial fibrosis (HP:0005576)1.64152389
157Supernumerary spleens (HP:0009799)1.63725479
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.62450688
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62093438
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.59952400
161Absent epiphyses (HP:0010577)1.59649295
162Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59649295
163Poor coordination (HP:0002370)1.59210574
164Stage 5 chronic kidney disease (HP:0003774)1.56919782
165Fibular hypoplasia (HP:0003038)1.56515405
166Abnormality of the dental pulp (HP:0006479)1.54770631
167Short femoral neck (HP:0100864)1.54339644
168Type 2 muscle fiber atrophy (HP:0003554)1.53473599
169Short thorax (HP:0010306)1.53266194
170Microglossia (HP:0000171)1.52423100
171Sloping forehead (HP:0000340)1.49810008
172Myositis (HP:0100614)1.49078434
173Bell-shaped thorax (HP:0001591)1.48566663
174Meckel diverticulum (HP:0002245)1.46288502
175Abnormality of the ileum (HP:0001549)1.45718752
176Chronic sinusitis (HP:0011109)1.43517906
177Constricted visual fields (HP:0001133)1.42639555
178Nephropathy (HP:0000112)1.41735958
179Abnormality of the preputium (HP:0100587)1.40931260
180Muscle fibrillation (HP:0010546)1.40581917
181Short ribs (HP:0000773)1.38833276
182Anencephaly (HP:0002323)1.37927557
183Genital tract atresia (HP:0001827)1.37763816
184Lissencephaly (HP:0001339)1.37618039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.24761995
2PDK47.24761995
3TESK15.43354997
4PDK24.89667602
5MAP4K24.01435833
6INSRR3.64483057
7EPHA23.64128359
8PRKD33.60342732
9BCKDK3.55546784
10ICK3.53113645
11FRK2.82588097
12MAPK152.69553849
13DDR22.51392608
14MST1R2.47012064
15EIF2AK32.22478688
16PKN22.21370144
17MST41.99034516
18PTK2B1.95581029
19VRK21.93203722
20CCNB11.79732071
21FGFR41.79315536
22TRIM281.78438753
23NEK21.68647520
24FLT31.67312006
25FGFR21.60678667
26CASK1.58536566
27ARAF1.55951481
28ZAK1.52829398
29MAPKAPK31.42037668
30PLK41.39284863
31STK38L1.34781064
32PLK21.29755931
33STK381.28479256
34BUB11.27051210
35FGFR31.23999724
36TXK1.22701039
37STK161.21704161
38PNCK1.20535008
39EIF2AK11.14250059
40ERN11.12337648
41MAP3K21.11358869
42IRAK21.06325568
43ATR1.04725253
44WEE11.02298201
45FGFR11.02218147
46TTK1.01907590
47MET1.01337422
48SRPK11.01323118
49IRAK11.00374079
50MAPK110.98096134
51FER0.93157411
52CHEK20.92180789
53WNK40.89719913
54PASK0.88076652
55MAP2K70.85274511
56STK390.84916058
57DYRK30.84612478
58SIK20.84401927
59PIM20.84102478
60TLK10.83491425
61MUSK0.82170758
62DYRK1B0.82057172
63AKT30.82011342
64PRKAA20.80441703
65PRKG20.80006743
66MAP3K90.79457837
67NME20.78606992
68YES10.78379196
69PDK10.76651028
70MAP3K120.74352517
71PLK10.72738164
72PRKCI0.71927073
73EIF2AK20.71759088
74TAOK20.71259259
75CDC70.70137676
76SIK30.70035133
77NEK60.68868718
78NME10.67416754
79PINK10.67000058
80GRK10.63414878
81BMPR20.62149251
82IRAK30.60003971
83PTK20.59417379
84CLK10.59258063
85ERBB30.57994431
86BRAF0.57467706
87STK30.56991471
88CHEK10.56779535
89RPS6KB10.55975184
90MAP2K60.55727866
91IRAK40.53770597
92PHKG20.53415257
93PHKG10.53415257
94TSSK60.51849102
95BCR0.51833415
96MKNK20.51396656
97CDK30.51371520
98BMPR1B0.50720152
99VRK10.49431510
100PRPF4B0.48049615
101CDK120.47779262
102PIM10.47535703
103LIMK10.47467403
104WNK30.47132285
105ATM0.46136856
106PRKAA10.45921694
107PLK30.45206595
108PRKCE0.45177762
109RIPK40.45120202
110BRSK10.44535441
111ROCK10.41982256
112NEK10.40820157
113MAP3K30.40667387
114MAP3K140.40479640
115BRSK20.39060753
116HIPK20.37458629
117ZAP700.36790524
118SIK10.36633827
119TESK20.36468994
120TGFBR20.35884090
121CDK70.34005537
122PRKCG0.33943882
123CSNK2A10.33593337
124CDK80.32186680
125GRK50.31663675
126AKT20.31135777
127PAK40.28545635
128WNK10.28511386
129AURKA0.27570118
130PAK10.27084002
131MAPKAPK50.26385691
132ADRBK20.26349033
133CDK90.25667906
134MKNK10.24623420
135MYLK0.23521513
136ADRBK10.23382585
137SGK20.23332498
138KIT0.23209824
139PRKCD0.22730538
140IKBKB0.22582523
141CHUK0.21707097
142PRKG10.21054105
143STK40.20817643
144AURKB0.20574176
145MAP3K50.20214194
146DAPK10.19120953
147PDPK10.18650387
148BMX0.18544447
149NTRK30.18000643
150MAP3K70.17779177
151EPHB20.17745093
152BRD40.17346540
153NUAK10.17075565
154TNK20.16976407
155CDK10.16039302
156MAP4K10.14799858
157LMTK20.13185102
158IKBKE0.12835740
159CSNK2A20.12603269
160BTK0.12567805

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.67297742
2Fanconi anemia pathway_Homo sapiens_hsa034603.63535150
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.41825220
4Basal transcription factors_Homo sapiens_hsa030223.40755532
5Fatty acid biosynthesis_Homo sapiens_hsa000613.06475561
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.78962159
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.77149975
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.75766532
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.72400311
10Homologous recombination_Homo sapiens_hsa034402.69341717
11Complement and coagulation cascades_Homo sapiens_hsa046102.29073395
12DNA replication_Homo sapiens_hsa030302.20508698
13Butanoate metabolism_Homo sapiens_hsa006502.13929477
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06170270
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.04228650
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04132912
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.98464811
18Linoleic acid metabolism_Homo sapiens_hsa005911.95442202
19Base excision repair_Homo sapiens_hsa034101.93442049
20RNA transport_Homo sapiens_hsa030131.91643460
21Steroid biosynthesis_Homo sapiens_hsa001001.90245242
22Arginine and proline metabolism_Homo sapiens_hsa003301.85450111
23mRNA surveillance pathway_Homo sapiens_hsa030151.84380101
24Purine metabolism_Homo sapiens_hsa002301.83453029
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.76217889
26Pyrimidine metabolism_Homo sapiens_hsa002401.74337018
27Sulfur relay system_Homo sapiens_hsa041221.67822865
28Fatty acid degradation_Homo sapiens_hsa000711.66912254
29Pyruvate metabolism_Homo sapiens_hsa006201.62651272
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62472210
31Fat digestion and absorption_Homo sapiens_hsa049751.61025520
32Other glycan degradation_Homo sapiens_hsa005111.60006116
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57362112
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.55990445
35Arginine biosynthesis_Homo sapiens_hsa002201.52009787
36Cell cycle_Homo sapiens_hsa041101.50543647
37Non-homologous end-joining_Homo sapiens_hsa034501.48910161
38Galactose metabolism_Homo sapiens_hsa000521.46928811
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42608521
40Legionellosis_Homo sapiens_hsa051341.41184889
41Fatty acid elongation_Homo sapiens_hsa000621.39448258
42Pentose phosphate pathway_Homo sapiens_hsa000301.39061271
43Glucagon signaling pathway_Homo sapiens_hsa049221.38044291
44Nucleotide excision repair_Homo sapiens_hsa034201.36169511
45Nitrogen metabolism_Homo sapiens_hsa009101.34636495
46ABC transporters_Homo sapiens_hsa020101.32773383
47Proteasome_Homo sapiens_hsa030501.31789404
48RNA degradation_Homo sapiens_hsa030181.31121394
49Antigen processing and presentation_Homo sapiens_hsa046121.30820800
50Peroxisome_Homo sapiens_hsa041461.29601899
51Sphingolipid metabolism_Homo sapiens_hsa006001.28491078
52Starch and sucrose metabolism_Homo sapiens_hsa005001.27469910
53Mismatch repair_Homo sapiens_hsa034301.27286900
54Collecting duct acid secretion_Homo sapiens_hsa049661.26355145
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24670165
56Oocyte meiosis_Homo sapiens_hsa041141.22508203
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21731063
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21666515
59Spliceosome_Homo sapiens_hsa030401.20944616
60Protein export_Homo sapiens_hsa030601.18192461
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16681238
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16448501
63Vitamin digestion and absorption_Homo sapiens_hsa049771.15603485
64Allograft rejection_Homo sapiens_hsa053301.13833163
65Arachidonic acid metabolism_Homo sapiens_hsa005901.12260163
66Fructose and mannose metabolism_Homo sapiens_hsa000511.12193032
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11972364
68Graft-versus-host disease_Homo sapiens_hsa053321.11649366
69Circadian rhythm_Homo sapiens_hsa047101.10802626
70Ether lipid metabolism_Homo sapiens_hsa005651.08553363
71Selenocompound metabolism_Homo sapiens_hsa004501.08260611
72Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08112872
73Intestinal immune network for IgA production_Homo sapiens_hsa046721.07032833
74Huntingtons disease_Homo sapiens_hsa050161.06301677
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05901716
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05601128
77Cyanoamino acid metabolism_Homo sapiens_hsa004601.05447956
78Glycerophospholipid metabolism_Homo sapiens_hsa005641.04812020
79Phenylalanine metabolism_Homo sapiens_hsa003601.04090350
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03700612
81Propanoate metabolism_Homo sapiens_hsa006400.99082231
82Systemic lupus erythematosus_Homo sapiens_hsa053220.99008578
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96399154
84Tyrosine metabolism_Homo sapiens_hsa003500.93928065
85Autoimmune thyroid disease_Homo sapiens_hsa053200.91980506
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87561777
87Tryptophan metabolism_Homo sapiens_hsa003800.84206447
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84060555
89Lysine degradation_Homo sapiens_hsa003100.83315799
90Mineral absorption_Homo sapiens_hsa049780.82958475
91Herpes simplex infection_Homo sapiens_hsa051680.82919470
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82805342
93Rheumatoid arthritis_Homo sapiens_hsa053230.82593271
94Type I diabetes mellitus_Homo sapiens_hsa049400.81114904
95Measles_Homo sapiens_hsa051620.80773867
96Bile secretion_Homo sapiens_hsa049760.74317296
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72306522
98Glycerolipid metabolism_Homo sapiens_hsa005610.71112759
99Primary immunodeficiency_Homo sapiens_hsa053400.70513330
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68758712
101Hedgehog signaling pathway_Homo sapiens_hsa043400.68163336
102Amphetamine addiction_Homo sapiens_hsa050310.66920959
103Renin-angiotensin system_Homo sapiens_hsa046140.66903804
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.66406643
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65180526
106Caffeine metabolism_Homo sapiens_hsa002320.62233819
107Folate biosynthesis_Homo sapiens_hsa007900.61763686
108Epstein-Barr virus infection_Homo sapiens_hsa051690.61395841
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60066214
110Glutathione metabolism_Homo sapiens_hsa004800.59737968
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.59686569
112RNA polymerase_Homo sapiens_hsa030200.58567234
113Nicotine addiction_Homo sapiens_hsa050330.57789918
114Chemical carcinogenesis_Homo sapiens_hsa052040.57682691
115PPAR signaling pathway_Homo sapiens_hsa033200.56729452
116One carbon pool by folate_Homo sapiens_hsa006700.56296212
117Thyroid hormone synthesis_Homo sapiens_hsa049180.56040088
118Influenza A_Homo sapiens_hsa051640.56023843
119beta-Alanine metabolism_Homo sapiens_hsa004100.55703644
120Histidine metabolism_Homo sapiens_hsa003400.55655582
121Asthma_Homo sapiens_hsa053100.54625526
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.53573690
123Phagosome_Homo sapiens_hsa041450.53026658
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52321270
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52074343
126Synaptic vesicle cycle_Homo sapiens_hsa047210.51332142
127N-Glycan biosynthesis_Homo sapiens_hsa005100.50882686
128Metabolic pathways_Homo sapiens_hsa011000.49679524
129Phototransduction_Homo sapiens_hsa047440.48937992
130p53 signaling pathway_Homo sapiens_hsa041150.48129800
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46517179
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45725083
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44199741
134HIF-1 signaling pathway_Homo sapiens_hsa040660.43703018
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.43031074
136Fatty acid metabolism_Homo sapiens_hsa012120.42956884
137Carbon metabolism_Homo sapiens_hsa012000.41221292
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40965264
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40723578
140Viral carcinogenesis_Homo sapiens_hsa052030.39511626
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38863006
142Insulin resistance_Homo sapiens_hsa049310.38853964
143Salivary secretion_Homo sapiens_hsa049700.37787961
144Basal cell carcinoma_Homo sapiens_hsa052170.37415746
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35296405
146Retinol metabolism_Homo sapiens_hsa008300.34312328
147Protein digestion and absorption_Homo sapiens_hsa049740.34153167
148Oxidative phosphorylation_Homo sapiens_hsa001900.33802273
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32861963
150Biosynthesis of amino acids_Homo sapiens_hsa012300.32248893
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31992931
152Sulfur metabolism_Homo sapiens_hsa009200.31610181
153Salmonella infection_Homo sapiens_hsa051320.28119933
154HTLV-I infection_Homo sapiens_hsa051660.27485686

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