SPAG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.86395034
2piRNA metabolic process (GO:0034587)8.19186764
3* axonemal dynein complex assembly (GO:0070286)7.23203121
4male meiosis (GO:0007140)7.19857690
5fusion of sperm to egg plasma membrane (GO:0007342)6.71440335
6left/right axis specification (GO:0070986)6.45847456
7epithelial cilium movement (GO:0003351)6.22419996
8multicellular organism reproduction (GO:0032504)6.03442053
9sperm motility (GO:0030317)5.94774655
10cilium movement (GO:0003341)5.92518502
11synaptonemal complex organization (GO:0070193)5.88486457
12response to xenobiotic stimulus (GO:0009410)5.74108135
13synaptonemal complex assembly (GO:0007130)5.72082719
14acrosome assembly (GO:0001675)5.67795593
15DNA methylation involved in gamete generation (GO:0043046)5.60469487
16motile cilium assembly (GO:0044458)5.54806398
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.18336586
18plasma membrane fusion (GO:0045026)5.18087551
19diterpenoid biosynthetic process (GO:0016102)5.13480779
20sperm-egg recognition (GO:0035036)5.12695007
21spermatid development (GO:0007286)5.10511133
22left/right pattern formation (GO:0060972)5.04925613
23pyrimidine-containing compound transmembrane transport (GO:0072531)4.92326731
24male meiosis I (GO:0007141)4.88147317
25meiotic cell cycle (GO:0051321)4.87157032
26regulation of meiosis I (GO:0060631)4.86991206
27acrosome reaction (GO:0007340)4.86290532
28monoubiquitinated protein deubiquitination (GO:0035520)4.69616778
29reproduction (GO:0000003)4.67546783
30binding of sperm to zona pellucida (GO:0007339)4.62157696
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.59440369
32cell-cell recognition (GO:0009988)4.51041383
33negative regulation of T cell differentiation in thymus (GO:0033085)4.42566111
34cell wall macromolecule metabolic process (GO:0044036)4.41086386
35cell wall macromolecule catabolic process (GO:0016998)4.41086386
36negative regulation of humoral immune response (GO:0002921)4.40851062
37meiotic nuclear division (GO:0007126)4.35608805
38regulation of cilium movement (GO:0003352)4.30167956
39meiosis I (GO:0007127)4.17562031
40chromosome organization involved in meiosis (GO:0070192)4.16874220
41microtubule severing (GO:0051013)4.05290328
42* single fertilization (GO:0007338)4.04899286
43negative regulation of inclusion body assembly (GO:0090084)3.98886559
44* fertilization (GO:0009566)3.98002564
45pyrimidine nucleoside salvage (GO:0043097)3.89886726
46pyrimidine-containing compound salvage (GO:0008655)3.89886726
47spermatogenesis (GO:0007283)3.88093948
48male gamete generation (GO:0048232)3.86666140
49gamete generation (GO:0007276)3.82727318
50primary alcohol catabolic process (GO:0034310)3.82032617
51microtubule depolymerization (GO:0007019)3.72930925
52ventricular system development (GO:0021591)3.70450784
53pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.65058271
54UMP metabolic process (GO:0046049)3.65058271
55pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.65058271
56UMP biosynthetic process (GO:0006222)3.65058271
57cilium morphogenesis (GO:0060271)3.61428462
58intestinal epithelial cell development (GO:0060576)3.55971735
59gene silencing by RNA (GO:0031047)3.55968703
60terpenoid biosynthetic process (GO:0016114)3.53059021
61microtubule bundle formation (GO:0001578)3.48807730
62mitotic sister chromatid cohesion (GO:0007064)3.47294019
63female gamete generation (GO:0007292)3.46561037
64germ cell development (GO:0007281)3.44172684
65regulation of meiosis (GO:0040020)3.40460277
66meiotic cell cycle process (GO:1903046)3.36419188
67cellular process involved in reproduction in multicellular organism (GO:0022412)3.36151966
68nuclear pore complex assembly (GO:0051292)3.33658588
69cysteine metabolic process (GO:0006534)3.33313720
70tolerance induction (GO:0002507)3.27839342
71regulation of centriole replication (GO:0046599)3.27036150
72seminiferous tubule development (GO:0072520)3.24727248
73cell projection assembly (GO:0030031)3.24434522
74retinoic acid metabolic process (GO:0042573)3.22283419
75response to pheromone (GO:0019236)3.20669441
76nucleotide transmembrane transport (GO:1901679)3.19400568
77macroautophagy (GO:0016236)3.17121582
78multicellular organismal water homeostasis (GO:0050891)3.15120170
79L-fucose catabolic process (GO:0042355)3.14506378
80fucose catabolic process (GO:0019317)3.14506378
81L-fucose metabolic process (GO:0042354)3.14506378
82intraciliary transport (GO:0042073)3.14127419
83regulation of germinal center formation (GO:0002634)3.11362703
84vitamin transmembrane transport (GO:0035461)3.11330219
85positive regulation of meiotic cell cycle (GO:0051446)3.11051346
86DNA methylation (GO:0006306)3.11021718
87DNA alkylation (GO:0006305)3.11021718
88hepatocyte apoptotic process (GO:0097284)3.10498629
89centriole replication (GO:0007099)3.08228119
90negative regulation of complement activation (GO:0045916)3.08096479
91establishment of skin barrier (GO:0061436)3.07853988
92protein polyglutamylation (GO:0018095)3.06892960
93negative regulation of immunoglobulin mediated immune response (GO:0002890)3.04604513
94negative regulation of B cell mediated immunity (GO:0002713)3.04604513
95sperm capacitation (GO:0048240)3.01903320
96sister chromatid cohesion (GO:0007062)2.98018619
97multicellular organismal reproductive process (GO:0048609)2.96574091
98regulation of meiotic cell cycle (GO:0051445)2.93816156
99synapsis (GO:0007129)2.92594241
100cilium organization (GO:0044782)2.90358781
101carnitine metabolic process (GO:0009437)2.89411534
102calcium ion-dependent exocytosis (GO:0017156)2.89226524
103exogenous drug catabolic process (GO:0042738)2.88835542
104phenylpropanoid metabolic process (GO:0009698)2.86515805
105ER overload response (GO:0006983)2.85305051
106regulation of autophagic vacuole assembly (GO:2000785)2.85166969
107microtubule-based movement (GO:0007018)2.83857486
108negative regulation of meiosis (GO:0045835)2.82889400
109cilium assembly (GO:0042384)2.82426021
110ethanol metabolic process (GO:0006067)2.79882599
111axoneme assembly (GO:0035082)2.79061263
112positive regulation of meiosis (GO:0045836)2.78188319
113water homeostasis (GO:0030104)2.78108750
114oocyte maturation (GO:0001556)2.77626706
115drug catabolic process (GO:0042737)2.77133667
116O-glycan processing (GO:0016266)2.75685286
117negative regulation of protein activation cascade (GO:2000258)2.75395823
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.75038734
119cytoplasmic mRNA processing body assembly (GO:0033962)2.73705351
120centriole assembly (GO:0098534)2.73492163
121positive regulation of defense response to virus by host (GO:0002230)2.73262011
122regulation of inclusion body assembly (GO:0090083)2.72491539
123pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.72240673
124negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.70399747
125glomerular epithelial cell development (GO:0072310)2.67256096
126one-carbon compound transport (GO:0019755)2.66087257
127glutathione derivative metabolic process (GO:1901685)2.65964816
128glutathione derivative biosynthetic process (GO:1901687)2.65964816
129nucleoside diphosphate phosphorylation (GO:0006165)2.64193491
130cytoplasmic microtubule organization (GO:0031122)2.64138839
131regulation of interleukin-5 production (GO:0032674)2.63326674
132histone exchange (GO:0043486)2.63228689
133mitotic chromosome condensation (GO:0007076)2.62510259
134gene silencing (GO:0016458)2.61224785
135eye photoreceptor cell differentiation (GO:0001754)2.61126110
136photoreceptor cell differentiation (GO:0046530)2.61126110
137nuclear pore organization (GO:0006999)2.59707388
138tight junction assembly (GO:0070830)2.57820263
139retinol metabolic process (GO:0042572)2.57705592
140protein K11-linked deubiquitination (GO:0035871)2.57618400
141regulation of vacuole organization (GO:0044088)2.55461275
142DNA damage response, signal transduction resulting in transcription (GO:0042772)2.54631819
143positive regulation of prostaglandin secretion (GO:0032308)2.54389866
144ear development (GO:0043583)2.54215721
145keratinocyte development (GO:0003334)2.53516178
146amino-acid betaine metabolic process (GO:0006577)2.52897114
147regulation of microtubule-based movement (GO:0060632)2.52808325
148DNA packaging (GO:0006323)2.52776306
149chromosome condensation (GO:0030261)2.52724439
150mitotic metaphase plate congression (GO:0007080)2.52579352
151protein localization to cilium (GO:0061512)2.52320305
152neural tube formation (GO:0001841)2.52232275
153negative regulation of meiotic cell cycle (GO:0051447)2.51728317
154regulation of water loss via skin (GO:0033561)2.51511237
155cellular component assembly involved in morphogenesis (GO:0010927)2.51206955
156retinal metabolic process (GO:0042574)2.51159618
157regulation of protein polyubiquitination (GO:1902914)2.50613139
158regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.49692718
159desmosome organization (GO:0002934)2.49403469
160genitalia morphogenesis (GO:0035112)2.49297515
161nucleus organization (GO:0006997)2.49038003
162L-ascorbic acid metabolic process (GO:0019852)2.48131481
163oogenesis (GO:0048477)2.47851152
164glutathione biosynthetic process (GO:0006750)2.47298542
165negative regulation of hormone metabolic process (GO:0032351)2.46556275
166negative regulation of hormone biosynthetic process (GO:0032353)2.46556275
167cell recognition (GO:0008037)2.44376534
168sphingomyelin metabolic process (GO:0006684)2.43179268
169photoreceptor cell maintenance (GO:0045494)2.41524086
170regulation of interleukin-13 production (GO:0032656)2.39592016
171hydrogen peroxide biosynthetic process (GO:0050665)2.37935867
172determination of left/right symmetry (GO:0007368)2.37753841
173negative regulation of acute inflammatory response (GO:0002674)2.35341990
174primary alcohol metabolic process (GO:0034308)2.34538359
175UDP-N-acetylglucosamine metabolic process (GO:0006047)2.34310670
176pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.29642317
177fucosylation (GO:0036065)2.29488179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.21249298
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.69697524
3EZH2_22144423_ChIP-Seq_EOC_Human4.08879930
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.82967783
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.25992196
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03959507
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.85109727
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62787765
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.61904440
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.60702897
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46633777
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35479019
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.20076358
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.19415980
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.14817010
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.10404344
17AHR_22903824_ChIP-Seq_MCF-7_Human2.06329929
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.05015124
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01327889
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98150670
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.94116487
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.92113970
23TP53_16413492_ChIP-PET_HCT116_Human1.90239872
24ARNT_22903824_ChIP-Seq_MCF-7_Human1.90033498
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87958874
26TP63_23658742_ChIP-Seq_EP156T_Human1.87644464
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87500493
28AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.82297899
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76507635
30SOX2_20726797_ChIP-Seq_SW620_Human1.75555581
31FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.74365981
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71810000
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.68708648
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.67801997
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67111144
36RNF2_27304074_Chip-Seq_NSC_Mouse1.67092438
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66100711
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66100711
39* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62998270
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62529040
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62466187
42GATA4_25053715_ChIP-Seq_YYC3_Human1.61740157
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61126569
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61097020
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.59281126
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.59119575
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.57460612
48* GATA3_24758297_ChIP-Seq_MCF-7_Human1.57275517
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56488346
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56099498
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.54630683
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54423690
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53714321
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52542708
55CJUN_26792858_Chip-Seq_BT549_Human1.52481469
56STAT3_23295773_ChIP-Seq_U87_Human1.52148786
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51105429
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51105429
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50386928
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50358510
61FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.49025665
62AR_21572438_ChIP-Seq_LNCaP_Human1.47253838
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47117061
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46112042
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44588597
66* RUNX1_27514584_Chip-Seq_MCF-7_Human1.43965579
67SMAD4_21799915_ChIP-Seq_A2780_Human1.43269826
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43105943
69REST_21632747_ChIP-Seq_MESCs_Mouse1.41394100
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.41359650
71ZNF274_21170338_ChIP-Seq_K562_Hela1.40953904
72GBX2_23144817_ChIP-Seq_PC3_Human1.40213612
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.39857116
74TCF4_23295773_ChIP-Seq_U87_Human1.38448877
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38378979
76IGF1R_20145208_ChIP-Seq_DFB_Human1.37998073
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37432629
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36485107
79* FOXA1_25552417_ChIP-Seq_VCAP_Human1.35604069
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34905189
81KLF5_25053715_ChIP-Seq_YYC3_Human1.33234285
82TP53_18474530_ChIP-ChIP_U2OS_Human1.32421907
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31726284
84TBL1_22424771_ChIP-Seq_293T_Human1.31481078
85RUNX1_26923725_Chip-Seq_HPCs_Mouse1.31268371
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31149155
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.30566452
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29658097
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28613203
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.28278324
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27795035
92VDR_22108803_ChIP-Seq_LS180_Human1.26353710
93GATA6_25053715_ChIP-Seq_YYC3_Human1.24602965
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24140523
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22506587
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22251359
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22238565
98HNFA_21074721_ChIP-Seq_CACO-2_Human1.22080257
99PHF8_20622853_ChIP-Seq_HELA_Human1.21365550
100SMRT_27268052_Chip-Seq_Bcells_Human1.20866435
101FUS_26573619_Chip-Seq_HEK293_Human1.20349045
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19820149
103LXR_22158963_ChIP-Seq_LIVER_Mouse1.18973465
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18605746
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17795189
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17248764
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16855199
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.16340238
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16043003
110* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15035742
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14141374
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14082639
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.13744242
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13638262
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.13597559
116RBPJ_21746931_ChIP-Seq_IB4_Human1.13043199
117ER_23166858_ChIP-Seq_MCF-7_Human1.12365301
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12245019
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11956897
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11927718
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.10629349
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09994614
123GATA6_21074721_ChIP-Seq_CACO-2_Human1.09975985
124P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09108264
125P53_22387025_ChIP-Seq_ESCs_Mouse1.08977371
126GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08970234
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08847100
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07754663
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06995367
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06762022
131CTCF_18555785_Chip-Seq_ESCs_Mouse1.06369320
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06041172
133KLF4_18555785_Chip-Seq_ESCs_Mouse1.05812186
134STAT3_18555785_Chip-Seq_ESCs_Mouse1.05634199
135FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05420393
136FOXA1_25329375_ChIP-Seq_VCAP_Human1.05420393
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05136838
138WDR5_24793694_ChIP-Seq_LNCAP_Human1.04924814
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04829732
140AR_25329375_ChIP-Seq_VCAP_Human1.04773684
141CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03901089
142GATA2_21666600_ChIP-Seq_HMVEC_Human1.03666527
143AR_20517297_ChIP-Seq_VCAP_Human1.03396089
144SOX2_18555785_Chip-Seq_ESCs_Mouse1.03359215
145FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02882282
146ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02865691
147SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02767494
148FLI1_21867929_ChIP-Seq_TH2_Mouse1.02172930
149* GF1B_26923725_Chip-Seq_HPCs_Mouse1.02023967
150P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01796185
151ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01464924
152RXR_22158963_ChIP-Seq_LIVER_Mouse1.01019837
153P300_18555785_Chip-Seq_ESCs_Mouse1.00816379
154CDX2_22108803_ChIP-Seq_LS180_Human1.00703557
155PIAS1_25552417_ChIP-Seq_VCAP_Human1.00579208
156SMAD3_21741376_ChIP-Seq_ESCs_Human1.00370998
157STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00007567
158TAF15_26573619_Chip-Seq_HEK293_Human0.99741072
159KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99626086
160JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99249945
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.99052599
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.99012424
163TCF4_22108803_ChIP-Seq_LS180_Human0.98937965
164IRF8_22096565_ChIP-ChIP_GC-B_Human0.98728173
165NMYC_18555785_Chip-Seq_ESCs_Mouse0.98439451
166BCAT_22108803_ChIP-Seq_LS180_Human0.97868702
167ETV1_20927104_ChIP-Seq_GIST48_Human0.97783485
168NFYB_21822215_ChIP-Seq_K562_Human0.97003761
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.95684866
170GF1_26923725_Chip-Seq_HPCs_Mouse0.95556976
171CBP_20019798_ChIP-Seq_JUKART_Human0.94952016
172IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94952016
173RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94190730
174TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93549595
175FOXA2_19822575_ChIP-Seq_HepG2_Human0.92505837
176STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91604879
177* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90240904
178CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89309983
179RXR_22108803_ChIP-Seq_LS180_Human0.89216180
180TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88359918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.33452846
2MP0005451_abnormal_body_composition4.02644302
3MP0008875_abnormal_xenobiotic_pharmacok3.91354787
4MP0008877_abnormal_DNA_methylation3.88393275
5MP0002653_abnormal_ependyma_morphology3.56384605
6MP0001929_abnormal_gametogenesis3.50495791
7MP0003698_abnormal_male_reproductive3.33553233
8MP0002796_impaired_skin_barrier3.26101229
9MP0010234_abnormal_vibrissa_follicle3.18556604
10MP0005377_hearing/vestibular/ear_phenot2.93409779
11MP0003878_abnormal_ear_physiology2.93409779
12MP0002277_abnormal_respiratory_mucosa2.84794683
13MP0003787_abnormal_imprinting2.68350144
14MP0003252_abnormal_bile_duct2.66849499
15MP0002210_abnormal_sex_determination2.62812666
16MP0002139_abnormal_hepatobiliary_system2.59898329
17MP0002928_abnormal_bile_duct2.55850022
18MP0005084_abnormal_gallbladder_morpholo2.38953277
19MP0003195_calcinosis2.37132215
20MP0000653_abnormal_sex_gland2.20075689
21MP0009046_muscle_twitch2.20022979
22MP0008057_abnormal_DNA_replication2.16439015
23MP0003718_maternal_effect2.14746931
24MP0001145_abnormal_male_reproductive2.09646015
25MP0002161_abnormal_fertility/fecundity2.09333973
26MP0002876_abnormal_thyroid_physiology2.04613860
27MP0009780_abnormal_chondrocyte_physiolo2.02151602
28MP0002138_abnormal_hepatobiliary_system2.00126761
29MP0005085_abnormal_gallbladder_physiolo1.89258838
30MP0004043_abnormal_pH_regulation1.87917034
31MP0008961_abnormal_basal_metabolism1.85733765
32MP0005365_abnormal_bile_salt1.82545850
33MP0003866_abnormal_defecation1.81699271
34MP0004270_analgesia1.78400363
35MP0004859_abnormal_synaptic_plasticity1.72140707
36MP0005501_abnormal_skin_physiology1.70749004
37MP0010678_abnormal_skin_adnexa1.68935631
38MP0000647_abnormal_sebaceous_gland1.66322009
39MP0003111_abnormal_nucleus_morphology1.55377026
40MP0010094_abnormal_chromosome_stability1.53313009
41MP0003656_abnormal_erythrocyte_physiolo1.51025242
42MP0002132_abnormal_respiratory_system1.50870694
43MP0005310_abnormal_salivary_gland1.48607736
44MP0001765_abnormal_ion_homeostasis1.48234862
45MP0005408_hypopigmentation1.47408419
46MP0004145_abnormal_muscle_electrophysio1.47103503
47MP0002168_other_aberrant_phenotype1.45904455
48MP0004133_heterotaxia1.44253087
49MP0003941_abnormal_skin_development1.43510402
50MP0003950_abnormal_plasma_membrane1.37372219
51MP0003943_abnormal_hepatobiliary_system1.35991577
52MP0003183_abnormal_peptide_metabolism1.35360739
53MP0003699_abnormal_female_reproductive1.33882499
54MP0001984_abnormal_olfaction1.31841520
55MP0005165_increased_susceptibility_to1.31161720
56MP0000613_abnormal_salivary_gland1.30185280
57MP0003121_genomic_imprinting1.29632658
58MP0002282_abnormal_trachea_morphology1.28362439
59MP0000579_abnormal_nail_morphology1.27584152
60MP0000685_abnormal_immune_system1.26674076
61MP0002102_abnormal_ear_morphology1.26122826
62MP0003890_abnormal_embryonic-extraembry1.24510275
63MP0001944_abnormal_pancreas_morphology1.24268298
64MP0005275_abnormal_skin_tensile1.22778453
65MP0002160_abnormal_reproductive_system1.21840998
66MP0001790_abnormal_immune_system1.21541650
67MP0005387_immune_system_phenotype1.21541650
68MP0002693_abnormal_pancreas_physiology1.20505908
69MP0000465_gastrointestinal_hemorrhage1.20217872
70MP0003880_abnormal_central_pattern1.20082136
71MP0001873_stomach_inflammation1.19653997
72MP0003635_abnormal_synaptic_transmissio1.19016036
73MP0003879_abnormal_hair_cell1.17892946
74MP0004947_skin_inflammation1.17392079
75MP0001270_distended_abdomen1.15262811
76MP0003136_yellow_coat_color1.14190614
77MP0003693_abnormal_embryo_hatching1.13880320
78MP0002136_abnormal_kidney_physiology1.13293669
79MP0005647_abnormal_sex_gland1.13075958
80MP0003937_abnormal_limbs/digits/tail_de1.12659069
81MP0000371_diluted_coat_color1.12214083
82MP0001119_abnormal_female_reproductive1.09390598
83MP0005220_abnormal_exocrine_pancreas1.09298564
84MP0005623_abnormal_meninges_morphology1.08578675
85MP0000569_abnormal_digit_pigmentation1.07692060
86MP0008058_abnormal_DNA_repair1.07109262
87MP0003077_abnormal_cell_cycle1.06569143
88MP0005646_abnormal_pituitary_gland1.06445317
89MP0009643_abnormal_urine_homeostasis1.06268941
90MP0003763_abnormal_thymus_physiology1.05250787
91MP0001216_abnormal_epidermal_layer1.03687649
92MP0003123_paternal_imprinting1.02318093
93MP0000383_abnormal_hair_follicle1.01827530
94MP0000462_abnormal_digestive_system1.01183336
95MP0003191_abnormal_cellular_cholesterol1.00923097
96MP0005379_endocrine/exocrine_gland_phen1.00806833
97MP0000427_abnormal_hair_cycle1.00508634
98MP0002405_respiratory_system_inflammati0.99947039
99MP0010771_integument_phenotype0.99939927
100MP0003868_abnormal_feces_composition0.99100527
101MP0008995_early_reproductive_senescence0.99046461
102MP0003646_muscle_fatigue0.98860329
103MP0005636_abnormal_mineral_homeostasis0.97825896
104MP0002877_abnormal_melanocyte_morpholog0.97044587
105MP0006072_abnormal_retinal_apoptosis0.96888639
106MP0000609_abnormal_liver_physiology0.95675239
107MP0005248_abnormal_Harderian_gland0.95325732
108MP0004264_abnormal_extraembryonic_tissu0.95091220
109MP0004019_abnormal_vitamin_homeostasis0.95022905
110MP0009785_altered_susceptibility_to0.94903374
111MP0003011_delayed_dark_adaptation0.94328066
112MP0001486_abnormal_startle_reflex0.93503845
113MP0002098_abnormal_vibrissa_morphology0.93372879
114MP0001727_abnormal_embryo_implantation0.92877040
115MP0010155_abnormal_intestine_physiology0.92781432
116MP0002909_abnormal_adrenal_gland0.92682444
117MP0005551_abnormal_eye_electrophysiolog0.92655367
118MP0001800_abnormal_humoral_immune0.91883111
119MP0002184_abnormal_innervation0.89403593
120MP0003300_gastrointestinal_ulcer0.89283708
121MP0000627_abnormal_mammary_gland0.88817055
122MP0005187_abnormal_penis_morphology0.88256090
123MP0005164_abnormal_response_to0.88192307
124MP0005389_reproductive_system_phenotype0.88184396
125MP0002063_abnormal_learning/memory/cond0.88058785
126MP0005075_abnormal_melanosome_morpholog0.87803439
127MP0000778_abnormal_nervous_system0.87157147
128MP0003861_abnormal_nervous_system0.86562855
129MP0000377_abnormal_hair_follicle0.86337637
130MP0001666_abnormal_nutrient_absorption0.86010799
131MP0000566_synostosis0.86000483
132MP0002572_abnormal_emotion/affect_behav0.85563338
133MP0005395_other_phenotype0.85496859
134MP0002084_abnormal_developmental_patter0.83844391
135MP0006082_CNS_inflammation0.83753016
136MP0002272_abnormal_nervous_system0.82852397
137MP0005076_abnormal_cell_differentiation0.82835156
138MP0003045_fibrosis0.81584131
139MP0001881_abnormal_mammary_gland0.80936467
140MP0003755_abnormal_palate_morphology0.80309584
141MP0001851_eye_inflammation0.79171310
142MP0004381_abnormal_hair_follicle0.78996968
143MP0003638_abnormal_response/metabolism_0.78800607
144MP0000955_abnormal_spinal_cord0.78226314
145MP0002152_abnormal_brain_morphology0.78172670
146MP0000367_abnormal_coat/_hair0.77945277
147MP0003453_abnormal_keratinocyte_physiol0.77712469
148MP0004782_abnormal_surfactant_physiolog0.76655297
149MP0003806_abnormal_nucleotide_metabolis0.76345208
150MP0002060_abnormal_skin_morphology0.75575221
151MP0003632_abnormal_nervous_system0.75138282
152MP0002734_abnormal_mechanical_nocicepti0.75054128
153MP0002163_abnormal_gland_morphology0.74873703
154MP0004742_abnormal_vestibular_system0.74497071
155MP0001845_abnormal_inflammatory_respons0.73846232
156MP0009745_abnormal_behavioral_response0.73448596
157MP0004885_abnormal_endolymph0.73267049
158MP0010386_abnormal_urinary_bladder0.72587449
159MP0001299_abnormal_eye_distance/0.71741017
160MP0002009_preneoplasia0.69841447
161MP0002067_abnormal_sensory_capabilities0.69811870
162MP0000631_abnormal_neuroendocrine_gland0.69794994
163MP0001485_abnormal_pinna_reflex0.69787597
164MP0002085_abnormal_embryonic_tissue0.69092866
165MP0001440_abnormal_grooming_behavior0.68252821
166MP0004957_abnormal_blastocyst_morpholog0.68132942
167MP0001346_abnormal_lacrimal_gland0.66816604
168MP0006292_abnormal_olfactory_placode0.66659978
169MP0008569_lethality_at_weaning0.66081601
170MP0002882_abnormal_neuron_morphology0.65973629
171MP0002064_seizures0.65484554
172MP0001502_abnormal_circadian_rhythm0.64591522
173MP0002557_abnormal_social/conspecific_i0.64278552

Predicted human phenotypes

RankGene SetZ-score
1* Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.74276453
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.82890762
3Absent/shortened dynein arms (HP:0200106)7.82890762
4* Abnormal respiratory motile cilium physiology (HP:0012261)6.75376844
5Abnormal ciliary motility (HP:0012262)5.73872545
6Abnormal respiratory epithelium morphology (HP:0012253)5.51621378
7Abnormal respiratory motile cilium morphology (HP:0005938)5.51621378
8* Rhinitis (HP:0012384)5.12541912
9* Chronic bronchitis (HP:0004469)4.43712073
10Infertility (HP:0000789)4.22682070
11Male infertility (HP:0003251)4.12709588
12Chronic hepatic failure (HP:0100626)3.89706044
13Chronic sinusitis (HP:0011109)3.72618134
14Nephronophthisis (HP:0000090)3.39482786
15Papillary thyroid carcinoma (HP:0002895)3.21566752
16* Bronchiectasis (HP:0002110)3.07825484
17Recurrent bronchitis (HP:0002837)3.00013343
18Nasal polyposis (HP:0100582)2.94766017
19Hyperactive renin-angiotensin system (HP:0000841)2.91498414
20Abnormality of midbrain morphology (HP:0002418)2.77493670
21Molar tooth sign on MRI (HP:0002419)2.77493670
22Lip pit (HP:0100267)2.73556640
23Abnormality of the renal medulla (HP:0100957)2.71411708
24Chronic otitis media (HP:0000389)2.57560625
25Pancreatic fibrosis (HP:0100732)2.53240863
26Genetic anticipation (HP:0003743)2.48761130
27Medial flaring of the eyebrow (HP:0010747)2.46561188
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34827118
29Progressive cerebellar ataxia (HP:0002073)2.30294596
30Furrowed tongue (HP:0000221)2.29486466
31Oligodactyly (hands) (HP:0001180)2.27620940
32Bile duct proliferation (HP:0001408)2.27041594
33Abnormal biliary tract physiology (HP:0012439)2.27041594
34Abnormality of the lower motor neuron (HP:0002366)2.24765107
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21961592
36Curly hair (HP:0002212)2.19872190
37Congenital hepatic fibrosis (HP:0002612)2.09418372
38Gaze-evoked nystagmus (HP:0000640)2.09407645
39Congenital ichthyosiform erythroderma (HP:0007431)2.08993815
40Onycholysis (HP:0001806)2.08961469
41Postaxial foot polydactyly (HP:0001830)2.08532381
42Gait imbalance (HP:0002141)2.06486031
43Microglossia (HP:0000171)2.06448017
44Congenital primary aphakia (HP:0007707)2.05981796
45Increased IgE level (HP:0003212)2.05335995
46Tubulointerstitial nephritis (HP:0001970)2.04258402
47Chromsome breakage (HP:0040012)2.03766897
48* Bronchitis (HP:0012387)2.02419528
49Abnormality of the nasal mucosa (HP:0000433)2.02163407
50Fibular hypoplasia (HP:0003038)1.99025536
51Decreased circulating renin level (HP:0003351)1.98711694
52Supernumerary spleens (HP:0009799)1.97875770
53Atelectasis (HP:0100750)1.95698137
54Volvulus (HP:0002580)1.93769708
55Tubulointerstitial abnormality (HP:0001969)1.92047442
56Aplasia/Hypoplasia of the tongue (HP:0010295)1.91495977
57Genital tract atresia (HP:0001827)1.90429388
58Bell-shaped thorax (HP:0001591)1.89940284
59Nephrogenic diabetes insipidus (HP:0009806)1.89891826
60Absent frontal sinuses (HP:0002688)1.89099122
61Impulsivity (HP:0100710)1.88728535
62Male pseudohermaphroditism (HP:0000037)1.88631064
63Taurodontia (HP:0000679)1.87546571
64Abnormality of permanent molar morphology (HP:0011071)1.87546571
65Abnormality of the dental root (HP:0006486)1.87546571
66* Recurrent otitis media (HP:0000403)1.87443265
67Nephropathy (HP:0000112)1.87425564
68True hermaphroditism (HP:0010459)1.87139147
69Hyperkalemia (HP:0002153)1.86915994
70Ectopic kidney (HP:0000086)1.84417153
71Vascular calcification (HP:0004934)1.83687073
72Abnormality of the renal cortex (HP:0011035)1.83276673
73Abnormality of ocular smooth pursuit (HP:0000617)1.82583334
74Tubular atrophy (HP:0000092)1.82009179
75Ectropion (HP:0000656)1.81748782
76Vaginal atresia (HP:0000148)1.80205467
77Adrenal hypoplasia (HP:0000835)1.79802657
78Stage 5 chronic kidney disease (HP:0003774)1.79663430
79Occipital encephalocele (HP:0002085)1.78684941
80Poor coordination (HP:0002370)1.76594597
81Short nail (HP:0001799)1.76463191
82Sclerocornea (HP:0000647)1.76064967
83Anencephaly (HP:0002323)1.75732321
84Abnormality of molar (HP:0011077)1.74898192
85Abnormality of molar morphology (HP:0011070)1.74898192
86Aplasia/Hypoplasia of the lens (HP:0008063)1.74634459
87Aplasia/Hypoplasia of the fibula (HP:0006492)1.74363395
88Oligodactyly (HP:0012165)1.73577560
89Abnormal spermatogenesis (HP:0008669)1.73492987
90Glucose intolerance (HP:0000833)1.70600930
91Abnormality of chloride homeostasis (HP:0011422)1.70026906
92Polydipsia (HP:0001959)1.69872574
93Abnormal drinking behavior (HP:0030082)1.69872574
94Heterotopia (HP:0002282)1.69314639
95Large for gestational age (HP:0001520)1.68697813
96Cystic hygroma (HP:0000476)1.68387207
97Postaxial hand polydactyly (HP:0001162)1.66841657
98Aplasia involving bones of the upper limbs (HP:0009823)1.66665286
99Aplasia of the phalanges of the hand (HP:0009802)1.66665286
100Aplasia involving bones of the extremities (HP:0009825)1.66665286
101Gonadotropin excess (HP:0000837)1.66467961
102Abnormality of the dental pulp (HP:0006479)1.65864053
103Polyuria (HP:0000103)1.64562819
104Ketoacidosis (HP:0001993)1.63764158
105Tubulointerstitial fibrosis (HP:0005576)1.63467075
106Impaired smooth pursuit (HP:0007772)1.63364953
107Thyroid carcinoma (HP:0002890)1.63298129
108Abnormality of the labia minora (HP:0012880)1.60488770
109Hypoplastic labia majora (HP:0000059)1.58976894
110Amelogenesis imperfecta (HP:0000705)1.58370461
111Abnormality of renal excretion (HP:0011036)1.58368824
112Abnormality of the fingertips (HP:0001211)1.57195790
113Widely spaced teeth (HP:0000687)1.55661857
114Cystic liver disease (HP:0006706)1.54548163
115Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53397824
116Renal salt wasting (HP:0000127)1.53371661
117Breast hypoplasia (HP:0003187)1.51062212
118Oculomotor apraxia (HP:0000657)1.50218439
119Focal motor seizures (HP:0011153)1.49337496
120Abnormality of nail color (HP:0100643)1.49298419
121Pancreatic cysts (HP:0001737)1.48335601
122Abnormality of the labia majora (HP:0012881)1.47919059
123Abnormality of renin-angiotensin system (HP:0000847)1.47827204
124Autoimmune hemolytic anemia (HP:0001890)1.46919502
125Aplasia/Hypoplasia of the sternum (HP:0006714)1.46742434
126Alveolar cell carcinoma (HP:0006519)1.46571694
127Abnormality of the distal phalanges of the toes (HP:0010182)1.46125650
128Hyperaldosteronism (HP:0000859)1.46013085
129Recurrent sinusitis (HP:0011108)1.45543139
130Parakeratosis (HP:0001036)1.44890281
131Hypodontia (HP:0000668)1.43947255
132Short ribs (HP:0000773)1.43839428
133Conjugated hyperbilirubinemia (HP:0002908)1.43112131
134Cardiovascular calcification (HP:0011915)1.42518582
135Shawl scrotum (HP:0000049)1.42305225
136Cone-rod dystrophy (HP:0000548)1.41612315
137Amyotrophic lateral sclerosis (HP:0007354)1.40215905
138Astigmatism (HP:0000483)1.38669197
139Facial cleft (HP:0002006)1.38614328
140Abnormality of monocarboxylic acid metabolism (HP:0010996)1.38379554
141Median cleft lip (HP:0000161)1.37961828
142Intrahepatic cholestasis (HP:0001406)1.35384861
143Abnormality of macular pigmentation (HP:0008002)1.34911962
144Abnormality of the frontal sinuses (HP:0002687)1.33029192
145Azoospermia (HP:0000027)1.32786658
146Neoplasm of the tracheobronchial system (HP:0100552)1.30427596
147Abnormal urine output (HP:0012590)1.29867560
148Hypoplasia of the uterus (HP:0000013)1.29058355
149Abnormality of small intestinal villus morphology (HP:0011472)1.28018467
150Villous atrophy (HP:0011473)1.28018467
151Preaxial hand polydactyly (HP:0001177)1.27390360
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.26316215
153Abnormality of calcium-phosphate metabolism (HP:0100530)1.25673569
154Flat acetabular roof (HP:0003180)1.23486224
155Abnormal rod and cone electroretinograms (HP:0008323)1.20181367
156Asplenia (HP:0001746)1.19772991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.37302770
2MST45.16367217
3LATS14.69887337
4PDK33.93120021
5PDK43.93120021
6MAP3K123.79263296
7MST1R3.32572672
8ICK2.83696952
9PRKD32.67159712
10STK38L2.59941520
11LATS22.47105208
12PDK22.44849911
13PNCK2.20391698
14NEK22.15072573
15FRK2.13545588
16STK382.12005592
17EIF2AK32.11286158
18MET1.97234974
19TYRO31.93146257
20CDC71.88199293
21STK241.87610360
22TRPM71.86498997
23MAP3K91.83895098
24TTK1.83468013
25PLK41.81380493
26MAP3K61.79969711
27LMTK21.78660361
28PINK11.75394073
29STK31.68507529
30MUSK1.67254592
31MAP3K41.59154081
32MAP3K141.57999776
33TAOK31.56917684
34BLK1.55611112
35CHEK21.53821146
36NTRK31.51878325
37MOS1.48568973
38IRAK41.45931517
39EIF2AK11.45006981
40BMPR21.43118997
41CDK121.40645777
42BRAF1.35771335
43TAOK11.34108991
44PAK61.33921410
45PRKCI1.32326063
46WNK11.31720458
47SRPK11.31627284
48ERBB41.28072254
49STK391.25564311
50MAP3K21.25549227
51KSR21.24034908
52IKBKB1.21892603
53TBK11.21791886
54MAPKAPK31.21291815
55TLK11.17703701
56NTRK21.15789494
57MELK1.11021116
58TESK11.10060539
59MAP3K31.07922411
60CHUK1.05867333
61MAP2K71.01602690
62IKBKE0.99460459
63IRAK10.97931403
64WEE10.96828443
65MARK20.95320693
66MAP3K130.94428815
67WNK40.92413810
68PLK10.91939657
69TXK0.91812795
70CAMKK20.91792563
71PTK2B0.89572085
72CDK30.88403635
73CHEK10.86863214
74ERBB30.86642525
75PRKCQ0.86395968
76JAK10.84365924
77MAPK150.82118191
78MAPKAPK50.75775581
79SIK30.75528731
80RAF10.75395253
81PTK20.74514038
82ATM0.74052232
83HIPK20.73004555
84RIPK10.72978582
85MAPK130.72742718
86PIK3CA0.72511748
87CSK0.71233303
88AURKA0.70650416
89BCR0.69620281
90BRSK10.67504084
91DYRK1A0.67359294
92CDK90.66058278
93EEF2K0.65364988
94PRKD20.64762932
95NEK90.64709239
96TNIK0.63578168
97PRPF4B0.62852979
98GRK10.61927444
99IRAK30.60887407
100MAPK100.58328605
101EPHA40.58193162
102FER0.58176452
103PIM20.56358808
104ILK0.55059588
105CSNK1A1L0.54559024
106FGFR30.54500342
107NEK60.52157530
108PRKAA10.51370367
109DMPK0.50838163
110RPS6KB20.50836609
111MYLK0.50774536
112CDK10.49717474
113AURKB0.49627313
114CDK20.49237381
115NUAK10.48016658
116PRKCE0.47970364
117ARAF0.47657426
118ROCK10.46762531
119CSF1R0.46720615
120STK100.46595553
121GSK3B0.46219670
122CSNK1G20.45701297
123CSNK1D0.45165292
124BMPR1B0.43858837
125MTOR0.43747786
126BRD40.42391576
127PKN10.42086832
128CAMK1G0.41157171
129TNK20.40119246
130NME10.38951838
131SGK10.38850292
132DYRK20.38387635
133PDK10.36867529
134PRKAA20.36639735
135ROCK20.36549240
136MAP2K40.36147151
137CAMK2A0.35670852
138ATR0.35623316
139PRKDC0.34937028
140OXSR10.34518540
141RPS6KA30.34347166
142CSNK1E0.34177488
143BRSK20.33880880
144SGK20.33636895
145ABL10.33479200
146EIF2AK20.33377974
147PRKCD0.32771182
148SGK2230.31667206
149SGK4940.31667206
150WNK30.31539710
151MAPKAPK20.31427322
152MAPK140.31392067
153MATK0.31117703
154RPS6KA40.30758988
155PDPK10.30418337
156CAMK2G0.28100456
157FGFR10.26097305
158LRRK20.24494533
159CAMK2D0.22598944
160SCYL20.22495609
161ADRBK10.19605572
162EPHB10.19112190
163SMG10.17538354
164FGR0.17050982
165INSR0.16975632
166GSK3A0.16799462

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.33720025
2Caffeine metabolism_Homo sapiens_hsa002323.33610220
3Sulfur metabolism_Homo sapiens_hsa009203.16484611
4Vitamin B6 metabolism_Homo sapiens_hsa007502.89383751
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.89366816
6Dorso-ventral axis formation_Homo sapiens_hsa043202.84934547
7Chemical carcinogenesis_Homo sapiens_hsa052042.84180644
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.75205832
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.48381634
10Linoleic acid metabolism_Homo sapiens_hsa005912.44781638
11Phenylalanine metabolism_Homo sapiens_hsa003602.44776398
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44349077
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.36967412
14Oocyte meiosis_Homo sapiens_hsa041142.27420685
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.23281137
16Nicotine addiction_Homo sapiens_hsa050332.13476277
17Basal transcription factors_Homo sapiens_hsa030222.02600320
18Ether lipid metabolism_Homo sapiens_hsa005651.94369769
19Long-term potentiation_Homo sapiens_hsa047201.92736869
20Nitrogen metabolism_Homo sapiens_hsa009101.85954177
21Fanconi anemia pathway_Homo sapiens_hsa034601.82680352
22Histidine metabolism_Homo sapiens_hsa003401.82079407
23Glutamatergic synapse_Homo sapiens_hsa047241.77223243
24Retinol metabolism_Homo sapiens_hsa008301.76699354
25Amphetamine addiction_Homo sapiens_hsa050311.75988539
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.71210542
27Sphingolipid metabolism_Homo sapiens_hsa006001.69963374
28Circadian rhythm_Homo sapiens_hsa047101.65906360
29ABC transporters_Homo sapiens_hsa020101.65753168
30Tyrosine metabolism_Homo sapiens_hsa003501.65548680
31Cell cycle_Homo sapiens_hsa041101.64244663
32Ovarian steroidogenesis_Homo sapiens_hsa049131.63774487
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60055108
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.54191240
35mRNA surveillance pathway_Homo sapiens_hsa030151.49045788
36Bile secretion_Homo sapiens_hsa049761.48187333
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.48157851
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.47902590
39Long-term depression_Homo sapiens_hsa047301.45832464
40Glutathione metabolism_Homo sapiens_hsa004801.45614196
41RNA degradation_Homo sapiens_hsa030181.41503400
42GnRH signaling pathway_Homo sapiens_hsa049121.41255937
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38655983
44Taste transduction_Homo sapiens_hsa047421.38107653
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.37790530
46Circadian entrainment_Homo sapiens_hsa047131.37018856
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36674251
48beta-Alanine metabolism_Homo sapiens_hsa004101.30873785
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29374674
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28228182
51Hepatitis C_Homo sapiens_hsa051601.24280804
52Estrogen signaling pathway_Homo sapiens_hsa049151.24183179
53Insulin secretion_Homo sapiens_hsa049111.22426717
54Synaptic vesicle cycle_Homo sapiens_hsa047211.22048165
55Protein export_Homo sapiens_hsa030601.17780773
56Olfactory transduction_Homo sapiens_hsa047401.17435834
57Fatty acid biosynthesis_Homo sapiens_hsa000611.16137874
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15296520
59Renin secretion_Homo sapiens_hsa049241.12328832
60Choline metabolism in cancer_Homo sapiens_hsa052311.12099725
61RNA transport_Homo sapiens_hsa030131.12089078
62Peroxisome_Homo sapiens_hsa041461.09713053
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09219879
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08899473
65NF-kappa B signaling pathway_Homo sapiens_hsa040641.06925043
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06521745
67Regulation of autophagy_Homo sapiens_hsa041401.05932408
68Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05645802
69ErbB signaling pathway_Homo sapiens_hsa040121.04998556
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04986863
71Dopaminergic synapse_Homo sapiens_hsa047281.04950288
72TNF signaling pathway_Homo sapiens_hsa046681.04632389
73Glucagon signaling pathway_Homo sapiens_hsa049221.03765523
74Serotonergic synapse_Homo sapiens_hsa047261.03760963
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02791930
76Salivary secretion_Homo sapiens_hsa049701.01033766
77Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00758771
78cAMP signaling pathway_Homo sapiens_hsa040240.99672214
79VEGF signaling pathway_Homo sapiens_hsa043700.98880539
80Arachidonic acid metabolism_Homo sapiens_hsa005900.98548219
81Cocaine addiction_Homo sapiens_hsa050300.98079605
82Oxytocin signaling pathway_Homo sapiens_hsa049210.97964761
83TGF-beta signaling pathway_Homo sapiens_hsa043500.97435298
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96266825
85Huntingtons disease_Homo sapiens_hsa050160.93974497
86Renal cell carcinoma_Homo sapiens_hsa052110.92975189
87Inositol phosphate metabolism_Homo sapiens_hsa005620.91243049
88Hedgehog signaling pathway_Homo sapiens_hsa043400.91051785
89Selenocompound metabolism_Homo sapiens_hsa004500.90765652
90Calcium signaling pathway_Homo sapiens_hsa040200.89978772
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88226614
92Hippo signaling pathway_Homo sapiens_hsa043900.88197244
93Endometrial cancer_Homo sapiens_hsa052130.87462784
94Morphine addiction_Homo sapiens_hsa050320.87013540
95GABAergic synapse_Homo sapiens_hsa047270.86921524
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.86437076
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85199563
98Wnt signaling pathway_Homo sapiens_hsa043100.84728412
99Axon guidance_Homo sapiens_hsa043600.84502324
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.83975801
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83578689
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82295522
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81522700
104MicroRNAs in cancer_Homo sapiens_hsa052060.80919991
105p53 signaling pathway_Homo sapiens_hsa041150.80607730
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.79747925
107Measles_Homo sapiens_hsa051620.79301959
108MAPK signaling pathway_Homo sapiens_hsa040100.79274449
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78683761
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77285183
111Gastric acid secretion_Homo sapiens_hsa049710.76981992
112Fatty acid degradation_Homo sapiens_hsa000710.76849157
113Butanoate metabolism_Homo sapiens_hsa006500.76691827
114Cholinergic synapse_Homo sapiens_hsa047250.76246916
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75602715
116Primary immunodeficiency_Homo sapiens_hsa053400.74878606
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74541180
118Ras signaling pathway_Homo sapiens_hsa040140.73936079
119Glioma_Homo sapiens_hsa052140.73593095
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.72726500
121Legionellosis_Homo sapiens_hsa051340.72615015
122Tight junction_Homo sapiens_hsa045300.71493486
123Basal cell carcinoma_Homo sapiens_hsa052170.71388669
124Type II diabetes mellitus_Homo sapiens_hsa049300.71216424
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68648718
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.64666004
127B cell receptor signaling pathway_Homo sapiens_hsa046620.64545935
128Prostate cancer_Homo sapiens_hsa052150.63597305
129Complement and coagulation cascades_Homo sapiens_hsa046100.62591746
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62546637
131Phototransduction_Homo sapiens_hsa047440.61937430
132T cell receptor signaling pathway_Homo sapiens_hsa046600.61521544
133Homologous recombination_Homo sapiens_hsa034400.61509297
134Prolactin signaling pathway_Homo sapiens_hsa049170.60982132
135PPAR signaling pathway_Homo sapiens_hsa033200.60921183
136Pancreatic secretion_Homo sapiens_hsa049720.60513657
137Sulfur relay system_Homo sapiens_hsa041220.60485258
138Pancreatic cancer_Homo sapiens_hsa052120.60285653
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59942417
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58039705
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55753206
142Alcoholism_Homo sapiens_hsa050340.55072511
143Adherens junction_Homo sapiens_hsa045200.54822026
144Melanogenesis_Homo sapiens_hsa049160.53941266
145Mineral absorption_Homo sapiens_hsa049780.53714964
146Gap junction_Homo sapiens_hsa045400.53555766
147FoxO signaling pathway_Homo sapiens_hsa040680.53025974
148Propanoate metabolism_Homo sapiens_hsa006400.52155833
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.52151052
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51331439
151Type I diabetes mellitus_Homo sapiens_hsa049400.50740323
152Insulin resistance_Homo sapiens_hsa049310.50567841
153Thyroid hormone synthesis_Homo sapiens_hsa049180.50226972
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49168787
155Lysosome_Homo sapiens_hsa041420.47371148
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46552946
157African trypanosomiasis_Homo sapiens_hsa051430.46274308
158Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45924479
159Antigen processing and presentation_Homo sapiens_hsa046120.45524736
160Collecting duct acid secretion_Homo sapiens_hsa049660.45189280
161Starch and sucrose metabolism_Homo sapiens_hsa005000.39914347
162Tryptophan metabolism_Homo sapiens_hsa003800.38166711
163Vibrio cholerae infection_Homo sapiens_hsa051100.37765494
164Influenza A_Homo sapiens_hsa051640.36666399
165Steroid biosynthesis_Homo sapiens_hsa001000.35573738
166Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35134717
167Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34786535
168Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32782899
169Cysteine and methionine metabolism_Homo sapiens_hsa002700.30442169
170Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28724182
171Folate biosynthesis_Homo sapiens_hsa007900.28592627
172Glycosaminoglycan degradation_Homo sapiens_hsa005310.27634491
173Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27537902
174Metabolic pathways_Homo sapiens_hsa011000.26961727
175Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26509457
176Small cell lung cancer_Homo sapiens_hsa052220.23661761

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