SPACA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.74161239
2acrosome assembly (GO:0001675)9.23493857
3sperm-egg recognition (GO:0035036)8.99164451
4reproduction (GO:0000003)8.42427714
5cell-cell recognition (GO:0009988)8.10914808
6motile cilium assembly (GO:0044458)7.83995894
7sperm motility (GO:0030317)7.77841002
8epithelial cilium movement (GO:0003351)7.58022060
9acrosome reaction (GO:0007340)7.20206280
10axonemal dynein complex assembly (GO:0070286)7.08015452
11binding of sperm to zona pellucida (GO:0007339)7.06791265
12spermatid development (GO:0007286)6.99305785
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.29349605
14cilium movement (GO:0003341)6.25459194
15single fertilization (GO:0007338)5.97049440
16male meiosis (GO:0007140)5.26718988
17microtubule depolymerization (GO:0007019)4.98883397
18piRNA metabolic process (GO:0034587)4.91567665
19regulation of cilium movement (GO:0003352)4.77426320
20calcium ion-dependent exocytosis (GO:0017156)4.72232012
21organic cation transport (GO:0015695)4.65567743
22cell recognition (GO:0008037)4.63587440
23fertilization (GO:0009566)4.46345366
24ventricular system development (GO:0021591)4.33608401
25sperm capacitation (GO:0048240)4.29683166
26polyketide metabolic process (GO:0030638)4.29601662
27doxorubicin metabolic process (GO:0044598)4.29601662
28daunorubicin metabolic process (GO:0044597)4.29601662
29synaptonemal complex organization (GO:0070193)4.00617894
30positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.83505917
31spermatogenesis (GO:0007283)3.77647003
32male gamete generation (GO:0048232)3.76655467
33protein localization to cilium (GO:0061512)3.72624293
34cellular process involved in reproduction in multicellular organism (GO:0022412)3.64098597
35germ cell development (GO:0007281)3.60898312
36synaptonemal complex assembly (GO:0007130)3.56320697
37fat-soluble vitamin biosynthetic process (GO:0042362)3.55548609
38gamete generation (GO:0007276)3.51770282
39inositol phosphate-mediated signaling (GO:0048016)3.48691359
40regulation of inositol phosphate biosynthetic process (GO:0010919)3.37874402
41regulation of inclusion body assembly (GO:0090083)3.37325242
42DNA methylation involved in gamete generation (GO:0043046)3.32552866
43male meiosis I (GO:0007141)3.27052496
44negative regulation of inclusion body assembly (GO:0090084)3.21463640
45glycerol metabolic process (GO:0006071)3.16650666
46spermatid nucleus differentiation (GO:0007289)3.16073357
47GTP biosynthetic process (GO:0006183)3.15126034
48intraciliary transport (GO:0042073)3.08197531
49regulation of meiosis I (GO:0060631)3.06053259
50alditol metabolic process (GO:0019400)3.02526912
51centriole assembly (GO:0098534)2.99503306
52glycerol ether metabolic process (GO:0006662)2.97289501
53atrial cardiac muscle cell action potential (GO:0086014)2.92606393
54chromosome organization involved in meiosis (GO:0070192)2.89027672
55centriole replication (GO:0007099)2.84489194
56left/right pattern formation (GO:0060972)2.83536238
57negative regulation of skeletal muscle tissue development (GO:0048642)2.83488329
58meiotic nuclear division (GO:0007126)2.79326291
59ether metabolic process (GO:0018904)2.76326486
60lactate metabolic process (GO:0006089)2.75783342
61UTP biosynthetic process (GO:0006228)2.72431573
62nucleoside diphosphate phosphorylation (GO:0006165)2.71809692
63multicellular organismal reproductive process (GO:0048609)2.70974303
64aminoglycoside antibiotic metabolic process (GO:0030647)2.70952610
65glutamate receptor signaling pathway (GO:0007215)2.69778707
66regulation of microtubule-based movement (GO:0060632)2.65652432
67UTP metabolic process (GO:0046051)2.63599478
68regulation of beta-amyloid formation (GO:1902003)2.61983999
69meiotic cell cycle (GO:0051321)2.60048969
70potassium ion export (GO:0071435)2.59857684
71synapsis (GO:0007129)2.58560565
72response to epinephrine (GO:0071871)2.57779056
73polyol catabolic process (GO:0046174)2.57480312
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.56630598
75ATP hydrolysis coupled proton transport (GO:0015991)2.56483053
76energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.56483053
77response to gravity (GO:0009629)2.56452346
78cellular ketone body metabolic process (GO:0046950)2.55638082
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53070372
80cilium morphogenesis (GO:0060271)2.53045166
81cilium assembly (GO:0042384)2.51545634
82single strand break repair (GO:0000012)2.50572129
83cellular component assembly involved in morphogenesis (GO:0010927)2.46690916
84microtubule polymerization or depolymerization (GO:0031109)2.45787169
85cilium organization (GO:0044782)2.45046795
86fructose metabolic process (GO:0006000)2.44731983
87cellular response to epinephrine stimulus (GO:0071872)2.43042197
88visual behavior (GO:0007632)2.41951365
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40008606
90cellular extravasation (GO:0045123)2.37325029
91meiosis I (GO:0007127)2.37080536
92phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)2.36471330
93chaperone-mediated protein complex assembly (GO:0051131)2.33831128
94negative regulation of epidermal cell differentiation (GO:0045605)2.33121477
95axoneme assembly (GO:0035082)2.32482817
96* cell wall macromolecule catabolic process (GO:0016998)14.6705823
97* cell wall macromolecule metabolic process (GO:0044036)14.6705823
98fusion of sperm to egg plasma membrane (GO:0007342)13.7681402
99plasma membrane fusion (GO:0045026)10.9530929
100multicellular organism reproduction (GO:0032504)10.5161517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.50869016
2EZH2_22144423_ChIP-Seq_EOC_Human4.57689096
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.83048449
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69973315
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.66570578
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.62490316
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60526157
8GBX2_23144817_ChIP-Seq_PC3_Human2.42996469
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41090529
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.40551988
11TAF15_26573619_Chip-Seq_HEK293_Human2.25544435
12ZNF274_21170338_ChIP-Seq_K562_Hela2.11391655
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10880446
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03337682
15REST_21632747_ChIP-Seq_MESCs_Mouse1.99018027
16TAL1_26923725_Chip-Seq_HPCs_Mouse1.94758134
17MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.88753140
18KAP1_22055183_ChIP-Seq_ESCs_Mouse1.88675939
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87352433
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.86834950
21FUS_26573619_Chip-Seq_HEK293_Human1.79591687
22CMYC_18555785_Chip-Seq_ESCs_Mouse1.75438535
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.75407845
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.73947534
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.72801082
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70467310
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.68212096
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.67595503
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65630747
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64396177
31KDM2B_26808549_Chip-Seq_REH_Human1.62954191
32OCT4_18555785_Chip-Seq_ESCs_Mouse1.60453107
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60376728
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.59410747
35KLF4_18555785_Chip-Seq_ESCs_Mouse1.57996473
36E2F1_18555785_Chip-Seq_ESCs_Mouse1.56072193
37SOX2_18555785_Chip-Seq_ESCs_Mouse1.55898091
38P53_22387025_ChIP-Seq_ESCs_Mouse1.52792878
39EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51692584
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50178635
41P300_18555785_Chip-Seq_ESCs_Mouse1.48555144
42SMAD4_21799915_ChIP-Seq_A2780_Human1.48358156
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47451561
44STAT3_18555785_Chip-Seq_ESCs_Mouse1.46962156
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46923917
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45480649
47TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.45077335
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45074262
49SMAD1_18555785_Chip-Seq_ESCs_Mouse1.44409528
50ESRRB_18555785_Chip-Seq_ESCs_Mouse1.42996626
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.42038038
52CTCF_18555785_Chip-Seq_ESCs_Mouse1.41880912
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41705035
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40293448
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40293448
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.38556855
57ZFX_18555785_Chip-Seq_ESCs_Mouse1.36854271
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35201101
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33402573
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33369281
61CBP_20019798_ChIP-Seq_JUKART_Human1.33369281
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33355564
63CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.32751588
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32360749
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32081572
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30894473
67RUNX1_27457419_Chip-Seq_LIVER_Mouse1.30782054
68PU1_27457419_Chip-Seq_LIVER_Mouse1.29497504
69IGF1R_20145208_ChIP-Seq_DFB_Human1.29443353
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29275241
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28424358
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25934535
73RNF2_27304074_Chip-Seq_NSC_Mouse1.24914155
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23749430
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23183625
76P300_19829295_ChIP-Seq_ESCs_Human1.22876857
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.22656734
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21037678
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18627724
80ER_23166858_ChIP-Seq_MCF-7_Human1.18062119
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16047136
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14739775
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13326360
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.13258760
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.12583137
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.11974897
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.10884991
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.09136681
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08373969
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07747831
91AR_25329375_ChIP-Seq_VCAP_Human1.07363314
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.07039757
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06508539
94GF1_26923725_Chip-Seq_HPCs_Mouse1.06306120
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05950161
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04124864
97VDR_22108803_ChIP-Seq_LS180_Human1.03864103
98SOX2_22085726_ChIP-Seq_NPCs_Mouse1.03456975
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.03209713
100STAT1_17558387_ChIP-Seq_HELA_Human1.03136183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.14635829
2MP0008004_abnormal_stomach_pH4.72758322
3MP0003698_abnormal_male_reproductive3.79975513
4MP0002736_abnormal_nociception_after3.57446365
5MP0001929_abnormal_gametogenesis3.24276106
6MP0008877_abnormal_DNA_methylation3.14865652
7MP0001502_abnormal_circadian_rhythm3.06883651
8MP0001968_abnormal_touch/_nociception2.94199420
9MP0009046_muscle_twitch2.40128440
10MP0008872_abnormal_physiological_respon2.11344529
11MP0002837_dystrophic_cardiac_calcinosis2.10249707
12MP0001440_abnormal_grooming_behavior2.07927973
13MP0002161_abnormal_fertility/fecundity2.00370645
14MP0004859_abnormal_synaptic_plasticity1.98801086
15MP0002210_abnormal_sex_determination1.93384838
16MP0003329_amyloid_beta_deposits1.88935771
17MP0003635_abnormal_synaptic_transmissio1.85627979
18MP0001984_abnormal_olfaction1.84401113
19MP0003941_abnormal_skin_development1.83904439
20MP0005535_abnormal_body_temperature1.75097044
21MP0004233_abnormal_muscle_weight1.73442519
22MP0001145_abnormal_male_reproductive1.72703547
23MP0002734_abnormal_mechanical_nocicepti1.70100252
24MP0000653_abnormal_sex_gland1.66571506
25MP0009745_abnormal_behavioral_response1.63593725
26MP0005623_abnormal_meninges_morphology1.62213045
27MP0004215_abnormal_myocardial_fiber1.61312723
28MP0001486_abnormal_startle_reflex1.61141525
29MP0002064_seizures1.60031415
30MP0002102_abnormal_ear_morphology1.57794049
31MP0002063_abnormal_learning/memory/cond1.56450754
32MP0002127_abnormal_cardiovascular_syste1.52373237
33MP0003011_delayed_dark_adaptation1.51566541
34MP0002572_abnormal_emotion/affect_behav1.48019165
35MP0004484_altered_response_of1.46754237
36MP0001485_abnormal_pinna_reflex1.44942143
37MP0005551_abnormal_eye_electrophysiolog1.44635293
38MP0004264_abnormal_extraembryonic_tissu1.41703881
39MP0001348_abnormal_lacrimal_gland1.40766024
40MP0002733_abnormal_thermal_nociception1.35500096
41MP0004742_abnormal_vestibular_system1.35484739
42MP0000462_abnormal_digestive_system1.34189002
43MP0002254_reproductive_system_inflammat1.29535603
44MP0002735_abnormal_chemical_nociception1.26551972
45MP0002557_abnormal_social/conspecific_i1.23114730
46MP0004270_analgesia1.20959563
47MP0000751_myopathy1.17808635
48MP0005365_abnormal_bile_salt1.16707513
49MP0001501_abnormal_sleep_pattern1.14220598
50MP0002272_abnormal_nervous_system1.13606206
51MP0001970_abnormal_pain_threshold1.12385913
52MP0005646_abnormal_pituitary_gland1.10101563
53MP0002067_abnormal_sensory_capabilities1.09634238
54MP0003880_abnormal_central_pattern1.07658425
55MP0001765_abnormal_ion_homeostasis1.04714908
56MP0002249_abnormal_larynx_morphology1.02025976
57MP0008875_abnormal_xenobiotic_pharmacok1.00966028
58MP0000566_synostosis0.99159292
59MP0004134_abnormal_chest_morphology0.96858192
60MP0000026_abnormal_inner_ear0.89514192
61MP0005647_abnormal_sex_gland0.89171019
62MP0006276_abnormal_autonomic_nervous0.88860070
63MP0003879_abnormal_hair_cell0.86422092
64MP0000604_amyloidosis0.85459520
65MP0004858_abnormal_nervous_system0.85236097
66MP0001963_abnormal_hearing_physiology0.84288727
67MP0009780_abnormal_chondrocyte_physiolo0.82558440
68MP0002066_abnormal_motor_capabilities/c0.81886138
69MP0006292_abnormal_olfactory_placode0.81371041
70MP0004924_abnormal_behavior0.81006691
71MP0005386_behavior/neurological_phenoty0.81006691
72MP0003183_abnormal_peptide_metabolism0.80867559
73MP0004883_abnormal_blood_vessel0.79980458
74MP0002282_abnormal_trachea_morphology0.79070593
75MP0002160_abnormal_reproductive_system0.78869503
76MP0002139_abnormal_hepatobiliary_system0.78768853
77MP0003690_abnormal_glial_cell0.76811305
78MP0005381_digestive/alimentary_phenotyp0.75065447
79MP0005253_abnormal_eye_physiology0.74860287
80MP0002069_abnormal_eating/drinking_beha0.74271610
81MP0005379_endocrine/exocrine_gland_phen0.73932122
82MP0003137_abnormal_impulse_conducting0.71896969
83MP0001986_abnormal_taste_sensitivity0.71769078
84MP0001664_abnormal_digestion0.71106048
85MP0009697_abnormal_copulation0.71077413
86MP0005165_increased_susceptibility_to0.69404800
87MP0002132_abnormal_respiratory_system0.68868865
88MP0002653_abnormal_ependyma_morphology0.67608310
89MP0005310_abnormal_salivary_gland0.67374543
90MP0002928_abnormal_bile_duct0.66676974
91MP0005394_taste/olfaction_phenotype0.65874140
92MP0005499_abnormal_olfactory_system0.65874140
93MP0001529_abnormal_vocalization0.62690196
94MP0003959_abnormal_lean_body0.61476614
95MP0002876_abnormal_thyroid_physiology0.60745216
96MP0001905_abnormal_dopamine_level0.60578983
97MP0001663_abnormal_digestive_system0.60431043
98MP0003787_abnormal_imprinting0.59895934
99MP0004019_abnormal_vitamin_homeostasis0.56974219
100MP0002234_abnormal_pharynx_morphology0.56700296

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.38695589
2Abnormal respiratory motile cilium morphology (HP:0005938)7.35306207
3Abnormal respiratory epithelium morphology (HP:0012253)7.35306207
4Abnormal ciliary motility (HP:0012262)6.66628605
5Rhinitis (HP:0012384)5.96633004
6Chronic bronchitis (HP:0004469)5.62726992
7Ventricular fibrillation (HP:0001663)4.06070937
8Infertility (HP:0000789)3.86756452
9Focal motor seizures (HP:0011153)3.84996420
10Nasal polyposis (HP:0100582)3.81214060
11Renal cortical cysts (HP:0000803)3.43703879
12Medial flaring of the eyebrow (HP:0010747)3.36395549
13Bronchiectasis (HP:0002110)3.23926062
14Bronchitis (HP:0012387)3.17705943
15Gait imbalance (HP:0002141)3.13654710
16Congenital primary aphakia (HP:0007707)3.02916493
17Abnormality of the nasal mucosa (HP:0000433)2.95499482
18Nephronophthisis (HP:0000090)2.92532397
19Bundle branch block (HP:0011710)2.68242133
20Abnormality of renal resorption (HP:0011038)2.63040465
21Widely patent fontanelles and sutures (HP:0004492)2.62736743
22Generalized aminoaciduria (HP:0002909)2.61179208
23Hepatic necrosis (HP:0002605)2.60860487
24Recurrent sinusitis (HP:0011108)2.60519247
25Abnormality of the renal cortex (HP:0011035)2.60089651
26Abnormal gallbladder physiology (HP:0012438)2.59616117
27Cholecystitis (HP:0001082)2.59616117
28Cerebellar dysplasia (HP:0007033)2.54834510
29Supernumerary spleens (HP:0009799)2.54148959
30Nephrogenic diabetes insipidus (HP:0009806)2.51437231
31Visual hallucinations (HP:0002367)2.51241701
32Neurofibrillary tangles (HP:0002185)2.33621534
33Tubulointerstitial nephritis (HP:0001970)2.30198779
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28722383
35Abnormality of the renal medulla (HP:0100957)2.27615031
36Vaginal atresia (HP:0000148)2.23888467
37Proximal tubulopathy (HP:0000114)2.22488084
38Male infertility (HP:0003251)2.22348418
39Genital tract atresia (HP:0001827)2.20653698
40Diplopia (HP:0000651)2.18760952
41Abnormality of binocular vision (HP:0011514)2.18760952
42Type II lissencephaly (HP:0007260)2.17341319
43Cerebral inclusion bodies (HP:0100314)2.14795322
44Polygenic inheritance (HP:0010982)2.12352494
45Chronic sinusitis (HP:0011109)2.12004626
46Tongue fasciculations (HP:0001308)2.05212929
47Hypoglycemic coma (HP:0001325)2.01869931
48Impaired smooth pursuit (HP:0007772)2.01015869
49Vascular calcification (HP:0004934)2.00385654
50Hemiparesis (HP:0001269)2.00351381
51Dynein arm defect of respiratory motile cilia (HP:0012255)10.3647154
52Absent/shortened dynein arms (HP:0200106)10.3647154
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1925732
54Epileptic encephalopathy (HP:0200134)1.96529508
55Abnormality of the costochondral junction (HP:0000919)1.96065037
56Congenital sensorineural hearing impairment (HP:0008527)1.95560101
57Hepatocellular necrosis (HP:0001404)1.94610445
58Poor coordination (HP:0002370)1.93213533
59Abnormality of ocular smooth pursuit (HP:0000617)1.92087465
60Muscle fibrillation (HP:0010546)1.91987368
61Limb ataxia (HP:0002070)1.90515701
62Decreased muscle mass (HP:0003199)1.90329948
63Methylmalonic acidemia (HP:0002912)1.88375071
64Thin bony cortex (HP:0002753)1.88086112
65Fatigable weakness (HP:0003473)1.87399577
66Abnormality of the neuromuscular junction (HP:0003398)1.87399577
67Pachygyria (HP:0001302)1.83618930
68Heart block (HP:0012722)1.83118666
69Molar tooth sign on MRI (HP:0002419)1.80683824
70Abnormality of midbrain morphology (HP:0002418)1.80683824
71Cardiovascular calcification (HP:0011915)1.79937518
72Recurrent otitis media (HP:0000403)1.76794108
73Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76514726
74Dicarboxylic aciduria (HP:0003215)1.76514726
75Methylmalonic aciduria (HP:0012120)1.74797360
76Type 2 muscle fiber atrophy (HP:0003554)1.73186309
77Broad foot (HP:0001769)1.70731644
78Abnormal biliary tract physiology (HP:0012439)1.70546941
79Bile duct proliferation (HP:0001408)1.70546941
80Left ventricular hypertrophy (HP:0001712)1.70023541
81Decreased central vision (HP:0007663)1.69438365
82Abnormal spermatogenesis (HP:0008669)1.69003049
83Poor suck (HP:0002033)1.68516434
84Opisthotonus (HP:0002179)1.67902739
85Aplasia/Hypoplasia of the lens (HP:0008063)1.65602283
86Delayed epiphyseal ossification (HP:0002663)1.62875871
87Impulsivity (HP:0100710)1.62423548
88Enlarged epiphyses (HP:0010580)1.62419968
89Abnormal atrioventricular conduction (HP:0005150)1.61962747
90Generalized muscle weakness (HP:0003324)1.61025093
91Abnormality of saccadic eye movements (HP:0000570)1.59252698
92Recurrent bronchitis (HP:0002837)1.54358577
93Fair hair (HP:0002286)1.53207378
94Hyperphosphatemia (HP:0002905)1.52210367
95Focal seizures (HP:0007359)1.51306587
96Abnormal EKG (HP:0003115)1.50871627
97Prolonged QT interval (HP:0001657)1.50613242
98Azoospermia (HP:0000027)1.49679553
99Buphthalmos (HP:0000557)1.47032330
100Syncope (HP:0001279)1.44380970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.02318098
2PDK46.02318098
3MAP3K64.68786156
4RIPK43.76698271
5PDK23.65123913
6BMPR22.50067124
7MAP2K42.42071617
8EPHA42.28091942
9MAP2K62.14347678
10MAP3K122.11152359
11PNCK2.08715983
12FRK2.05069039
13MAP2K31.89686220
14MAP3K91.89535114
15PBK1.82288936
16RIPK11.79746031
17AKT31.77208695
18LMTK21.64979611
19PTK2B1.61379023
20MINK11.60246808
21NTRK31.57970482
22STK391.57518122
23MUSK1.51320045
24PRKD21.38849093
25ADRBK11.32339313
26ADRBK21.30546165
27PRKCG1.23449110
28DAPK21.22182550
29OBSCN1.20088433
30MYLK1.15136706
31TESK11.13571535
32TNIK1.10566910
33CDK81.04588349
34CCNB11.03275479
35WNK41.02818491
36CASK0.98305760
37TTK0.97216131
38NME10.90373191
39PRKCH0.84506285
40FES0.84250947
41ZAP700.80790941
42NTRK20.79296578
43PLK20.78381722
44TYRO30.71683274
45INSRR0.70183841
46MAP3K40.69367595
47CAMK2A0.69328818
48PRKD30.68018433
49IRAK10.67684372
50MAP2K70.66668664
51GRK60.65834436
52STK380.63225419
53MOS0.61528293
54PIK3CG0.61397194
55RET0.60956518
56DAPK10.58662964
57GRK50.56667334
58PRKCE0.55349887
59TAOK30.54359612
60PLK40.51568811
61SYK0.51376549
62PKN10.50982004
63PDK10.50491159
64NUAK10.49002048
65PRKCA0.46433859
66MAP3K130.46375665
67PDPK10.45483112
68TIE10.43402938
69MAP3K50.43137069
70CAMK1G0.43039822
71PRKACA0.42608701
72BUB10.42017089
73BRAF0.41438308
74OXSR10.40802195
75ICK0.38571924
76MARK10.37102409
77PRKG10.37016529
78CHEK20.34309863
79ROCK20.34031407
80PAK40.30544881
81CDK120.29639497
82PRKCB0.28239253
83CLK10.26992943
84PASK0.24058498
85PRKACG0.23348865
86WNK10.22570468
87CDK50.21991535
88CSNK1D0.21122109
89CDK150.20906292
90CAMK10.20840428
91HCK0.19694059
92CDK180.19100474
93GRK10.18704290
94PAK10.18555128
95PRKD10.17890156
96FYN0.17606971
97CSNK1G20.17343602
98ERBB20.17044493
99CDK11A0.16637116
100PAK60.15930357

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006402.89173240
2Steroid biosynthesis_Homo sapiens_hsa001002.66525463
3Nicotine addiction_Homo sapiens_hsa050332.60119511
4Oxidative phosphorylation_Homo sapiens_hsa001902.59273423
5Synaptic vesicle cycle_Homo sapiens_hsa047212.40666844
6Pentose phosphate pathway_Homo sapiens_hsa000302.40550667
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.37509680
8Vitamin B6 metabolism_Homo sapiens_hsa007502.35624245
9Pyruvate metabolism_Homo sapiens_hsa006202.29470352
10Fatty acid biosynthesis_Homo sapiens_hsa000612.19462787
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19123699
12Huntingtons disease_Homo sapiens_hsa050162.17697155
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.13476835
14Collecting duct acid secretion_Homo sapiens_hsa049662.09160857
15Cardiac muscle contraction_Homo sapiens_hsa042602.02862203
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88398716
17Amphetamine addiction_Homo sapiens_hsa050311.86156120
18Parkinsons disease_Homo sapiens_hsa050121.74292767
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71244826
20Gastric acid secretion_Homo sapiens_hsa049711.70656945
21Alzheimers disease_Homo sapiens_hsa050101.66863325
22Glutamatergic synapse_Homo sapiens_hsa047241.65401786
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60112886
24Calcium signaling pathway_Homo sapiens_hsa040201.57912521
25Long-term potentiation_Homo sapiens_hsa047201.56577076
26Circadian entrainment_Homo sapiens_hsa047131.51377436
27Renin secretion_Homo sapiens_hsa049241.49057698
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40650318
29Salivary secretion_Homo sapiens_hsa049701.40109723
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.39726789
31Morphine addiction_Homo sapiens_hsa050321.33663508
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.29347216
33Olfactory transduction_Homo sapiens_hsa047401.28673909
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27737594
35Insulin secretion_Homo sapiens_hsa049111.27326081
36Vibrio cholerae infection_Homo sapiens_hsa051101.27305149
37Fructose and mannose metabolism_Homo sapiens_hsa000511.18854744
38Carbon metabolism_Homo sapiens_hsa012001.18751691
39Glucagon signaling pathway_Homo sapiens_hsa049221.17176219
40Dorso-ventral axis formation_Homo sapiens_hsa043201.15584832
41Taste transduction_Homo sapiens_hsa047421.12757853
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12682763
43Fatty acid metabolism_Homo sapiens_hsa012121.11931374
44N-Glycan biosynthesis_Homo sapiens_hsa005101.11025319
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02677142
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02607252
47GABAergic synapse_Homo sapiens_hsa047271.01314047
48Oocyte meiosis_Homo sapiens_hsa041140.99207254
49African trypanosomiasis_Homo sapiens_hsa051430.97410067
50Fatty acid degradation_Homo sapiens_hsa000710.97142286
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96863244
52Dopaminergic synapse_Homo sapiens_hsa047280.96552294
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96292714
54Long-term depression_Homo sapiens_hsa047300.92696773
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90744299
56Bile secretion_Homo sapiens_hsa049760.88118021
57PPAR signaling pathway_Homo sapiens_hsa033200.85297222
58Nitrogen metabolism_Homo sapiens_hsa009100.83654507
59Mineral absorption_Homo sapiens_hsa049780.82455365
60Biosynthesis of amino acids_Homo sapiens_hsa012300.79526496
61Serotonergic synapse_Homo sapiens_hsa047260.77125462
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76237356
63cAMP signaling pathway_Homo sapiens_hsa040240.73634550
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72806978
65Metabolic pathways_Homo sapiens_hsa011000.72322991
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68250167
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67683311
68Butanoate metabolism_Homo sapiens_hsa006500.65540193
69Phototransduction_Homo sapiens_hsa047440.65005358
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64834083
71Cocaine addiction_Homo sapiens_hsa050300.63344673
72Glycerolipid metabolism_Homo sapiens_hsa005610.61541063
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60185904
74Fatty acid elongation_Homo sapiens_hsa000620.59629060
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58952307
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.55991967
77Chemical carcinogenesis_Homo sapiens_hsa052040.52056154
78Renin-angiotensin system_Homo sapiens_hsa046140.50554245
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.48278251
80Sulfur relay system_Homo sapiens_hsa041220.47756326
81Arginine and proline metabolism_Homo sapiens_hsa003300.46325869
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45170822
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44666650
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43992655
85Starch and sucrose metabolism_Homo sapiens_hsa005000.42135576
86Cholinergic synapse_Homo sapiens_hsa047250.41476522
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40511386
88Purine metabolism_Homo sapiens_hsa002300.40043058
89Estrogen signaling pathway_Homo sapiens_hsa049150.40011178
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38297034
91Linoleic acid metabolism_Homo sapiens_hsa005910.38285269
92Pancreatic secretion_Homo sapiens_hsa049720.38039591
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37638650
94Thyroid hormone synthesis_Homo sapiens_hsa049180.37115261
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.36944537
96beta-Alanine metabolism_Homo sapiens_hsa004100.35852988
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33144514
98Glutathione metabolism_Homo sapiens_hsa004800.32770084
99GnRH signaling pathway_Homo sapiens_hsa049120.32635409
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31885102

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