SPA17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.89958701
2* cilium movement (GO:0003341)9.87969847
3reproduction (GO:0000003)9.19557315
4* binding of sperm to zona pellucida (GO:0007339)9.09455751
5* cell-cell recognition (GO:0009988)9.07061385
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.06426672
7spermatid development (GO:0007286)9.00123001
8regulation of cilium movement (GO:0003352)8.00480030
9piRNA metabolic process (GO:0034587)7.91439026
10male meiosis (GO:0007140)7.77932786
11synaptonemal complex organization (GO:0070193)7.23267121
12* single fertilization (GO:0007338)6.99478861
13synaptonemal complex assembly (GO:0007130)6.86374802
14sperm capacitation (GO:0048240)6.50137947
15negative regulation of inclusion body assembly (GO:0090084)6.24284819
16ventricular system development (GO:0021591)6.09774075
17* fertilization (GO:0009566)5.98487756
18* spermatogenesis (GO:0007283)5.88915228
19spermatid nucleus differentiation (GO:0007289)5.88448992
20* male gamete generation (GO:0048232)5.86689341
21axoneme assembly (GO:0035082)5.67688749
22microtubule depolymerization (GO:0007019)5.64738045
23* gamete generation (GO:0007276)5.41489429
24GTP biosynthetic process (GO:0006183)5.40814852
25DNA methylation involved in gamete generation (GO:0043046)5.31280233
26regulation of inclusion body assembly (GO:0090083)5.22556563
27male meiosis I (GO:0007141)5.16564284
28organic cation transport (GO:0015695)5.09742200
29germ cell development (GO:0007281)5.03904321
30nucleoside diphosphate phosphorylation (GO:0006165)5.03799328
31calcium ion-dependent exocytosis (GO:0017156)5.02806676
32cellular process involved in reproduction in multicellular organism (GO:0022412)4.94708896
33microtubule severing (GO:0051013)4.85147076
34UTP biosynthetic process (GO:0006228)4.76500440
35regulation of microtubule-based movement (GO:0060632)4.74451535
36chromosome organization involved in meiosis (GO:0070192)4.72067354
37intraciliary transport (GO:0042073)4.69705080
38* cell recognition (GO:0008037)4.45913136
39meiotic nuclear division (GO:0007126)4.45490800
40protein localization to cilium (GO:0061512)4.29138960
41UTP metabolic process (GO:0046051)4.26586646
42* multicellular organismal reproductive process (GO:0048609)4.26110980
43glycerol ether metabolic process (GO:0006662)4.24244189
44primary alcohol catabolic process (GO:0034310)4.18653022
45meiosis I (GO:0007127)4.14596732
46left/right pattern formation (GO:0060972)4.13847910
47cilium organization (GO:0044782)4.13716625
48protein polyglutamylation (GO:0018095)4.03260934
49cilium assembly (GO:0042384)3.97190791
50ether metabolic process (GO:0018904)3.94565359
51seminiferous tubule development (GO:0072520)3.91813450
52single strand break repair (GO:0000012)3.90648489
53meiotic cell cycle (GO:0051321)3.89231776
54guanosine-containing compound biosynthetic process (GO:1901070)3.88088263
55sexual reproduction (GO:0019953)3.75794754
56protein K11-linked deubiquitination (GO:0035871)3.75638860
57centriole assembly (GO:0098534)3.75491471
58cilium morphogenesis (GO:0060271)3.75318485
59cellular component assembly involved in morphogenesis (GO:0010927)3.70199115
60CTP biosynthetic process (GO:0006241)3.67726607
61CTP metabolic process (GO:0046036)3.67726607
62smoothened signaling pathway (GO:0007224)3.65435167
63cell projection assembly (GO:0030031)3.60530807
64centriole replication (GO:0007099)3.57310406
65nonmotile primary cilium assembly (GO:0035058)3.46723731
66left/right axis specification (GO:0070986)3.45921383
67monoubiquitinated protein deubiquitination (GO:0035520)3.44969798
68multicellular organismal development (GO:0007275)3.42888563
69chaperone-mediated protein complex assembly (GO:0051131)3.39411506
70determination of left/right symmetry (GO:0007368)3.38799025
71* microtubule-based movement (GO:0007018)3.36232756
72vitamin transmembrane transport (GO:0035461)3.34247467
73chromosome condensation (GO:0030261)3.32402673
74pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.32101921
75determination of bilateral symmetry (GO:0009855)3.26900356
76genitalia morphogenesis (GO:0035112)3.24966216
77specification of symmetry (GO:0009799)3.22004184
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.20410569
79protein refolding (GO:0042026)3.18100885
80DNA packaging (GO:0006323)3.10211084
81sequestering of actin monomers (GO:0042989)3.09645460
82lateral sprouting from an epithelium (GO:0060601)3.08221736
83microtubule polymerization or depolymerization (GO:0031109)3.06886512
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06510253
85lateral ventricle development (GO:0021670)3.05807178
86lactate metabolic process (GO:0006089)3.04241529
87pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.03691483
88aldehyde catabolic process (GO:0046185)3.02181034
89DNA ligation (GO:0006266)3.02150300
90diterpenoid biosynthetic process (GO:0016102)3.01722468
91establishment of planar polarity (GO:0001736)3.00833117
92establishment of tissue polarity (GO:0007164)3.00833117
93ethanol metabolic process (GO:0006067)2.91241276
94pyrimidine-containing compound transmembrane transport (GO:0072531)2.91025404
95polyol catabolic process (GO:0046174)2.88026428
96glutathione derivative metabolic process (GO:1901685)2.86174526
97glutathione derivative biosynthetic process (GO:1901687)2.86174526
98terpenoid biosynthetic process (GO:0016114)2.86084317
99* microtubule-based process (GO:0007017)2.85130864
100regulation of meiosis I (GO:0060631)2.82255270
101negative regulation of T cell differentiation in thymus (GO:0033085)2.80635286
102CENP-A containing nucleosome assembly (GO:0034080)2.80403592
103microtubule bundle formation (GO:0001578)2.80083842
104pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.78217665
105meiotic cell cycle process (GO:1903046)2.76902152
106organelle assembly (GO:0070925)2.76688279
107alditol metabolic process (GO:0019400)2.72803361
108energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72279409
109ATP synthesis coupled proton transport (GO:0015986)2.72279409
110chromatin remodeling at centromere (GO:0031055)2.71086628
111synapsis (GO:0007129)2.68749116
112establishment of protein localization to mitochondrial membrane (GO:0090151)2.68014905
113mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67961667
114nucleoside diphosphate metabolic process (GO:0009132)2.67707013
115nucleotide phosphorylation (GO:0046939)2.65480641
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62911694
117gene silencing by RNA (GO:0031047)2.57841346
118nucleus organization (GO:0006997)2.57555914
119organelle disassembly (GO:1903008)2.57226449
120lung epithelium development (GO:0060428)2.57144452
121glycolytic process (GO:0006096)2.56257224
122regulation of microtubule depolymerization (GO:0031114)2.55709927
123retinoic acid metabolic process (GO:0042573)2.54136494
124limb development (GO:0060173)2.53278895
125appendage development (GO:0048736)2.53278895
126regulation of collateral sprouting (GO:0048670)2.53147512
127one-carbon compound transport (GO:0019755)2.50446522
128cytoplasmic microtubule organization (GO:0031122)2.49874346
129protein neddylation (GO:0045116)2.44013684
130neuron fate determination (GO:0048664)2.43909903
131histone H2A acetylation (GO:0043968)2.43020856
132photoreceptor cell maintenance (GO:0045494)2.42806925
133kinetochore organization (GO:0051383)2.40922073
134resolution of meiotic recombination intermediates (GO:0000712)2.38857742
135negative regulation of microtubule depolymerization (GO:0007026)2.38304347
136apical protein localization (GO:0045176)2.34818959
137electron transport chain (GO:0022900)2.32705515
138glomerular epithelial cell development (GO:0072310)2.29304313
139retinal ganglion cell axon guidance (GO:0031290)2.29260208
140response to xenobiotic stimulus (GO:0009410)2.28336109
141positive regulation of smoothened signaling pathway (GO:0045880)2.27910399
142establishment of monopolar cell polarity (GO:0061162)2.27793913
143establishment or maintenance of monopolar cell polarity (GO:0061339)2.27793913
144intra-S DNA damage checkpoint (GO:0031573)2.27329151
145histone exchange (GO:0043486)2.26330724
146regulation of smoothened signaling pathway (GO:0008589)2.25051442
147substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.24355154
148substrate-independent telencephalic tangential migration (GO:0021826)2.24355154
149respiratory electron transport chain (GO:0022904)2.22491032
150spindle assembly involved in mitosis (GO:0090307)2.20873085
151dorsal/ventral pattern formation (GO:0009953)2.20211989
152kinetochore assembly (GO:0051382)2.20151108
153metaphase plate congression (GO:0051310)2.18708715
154retinal rod cell development (GO:0046548)2.16649932
155cornea development in camera-type eye (GO:0061303)2.15585908
156fusion of sperm to egg plasma membrane (GO:0007342)13.2479912
157cell wall macromolecule catabolic process (GO:0016998)12.5803715
158cell wall macromolecule metabolic process (GO:0044036)12.5803715
159sperm motility (GO:0030317)12.3391788
160cilium or flagellum-dependent cell motility (GO:0001539)12.0120926
161axonemal dynein complex assembly (GO:0070286)11.9315238
162acrosome assembly (GO:0001675)11.1305295
163multicellular organism reproduction (GO:0032504)10.7491804
164* epithelial cilium movement (GO:0003351)10.3639097
165acrosome reaction (GO:0007340)10.2298833
166* sperm-egg recognition (GO:0035036)10.1963524
167plasma membrane fusion (GO:0045026)10.0521715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.51906841
2EZH2_22144423_ChIP-Seq_EOC_Human4.50481507
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.26028534
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20064092
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.99329241
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81068610
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80698718
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74175709
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.63474924
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60684608
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.30894719
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25640640
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.19040221
14EWS_26573619_Chip-Seq_HEK293_Human2.17928855
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.17731430
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13067548
17VDR_22108803_ChIP-Seq_LS180_Human2.10344522
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.05992681
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03488649
20IGF1R_20145208_ChIP-Seq_DFB_Human1.99920788
21RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.91321669
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88973956
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.87818974
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.87159579
25ZNF274_21170338_ChIP-Seq_K562_Hela1.86274335
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83356190
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.78966586
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78683369
29CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.75637866
30* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.75594243
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73295673
32TAL1_26923725_Chip-Seq_HPCs_Mouse1.72267457
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.71245888
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.68534435
35ELK1_19687146_ChIP-ChIP_HELA_Human1.67866016
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66250141
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63638197
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63314661
39FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62215771
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61762875
41KDM2B_26808549_Chip-Seq_REH_Human1.59340428
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59169448
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58853927
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.57833208
45STAT1_17558387_ChIP-Seq_HELA_Human1.57047011
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56518775
47P300_19829295_ChIP-Seq_ESCs_Human1.56183945
48TAF15_26573619_Chip-Seq_HEK293_Human1.55461582
49RNF2_27304074_Chip-Seq_NSC_Mouse1.55450147
50ELK4_26923725_Chip-Seq_MESODERM_Mouse1.54841495
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54215814
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47759546
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47301282
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.47223459
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45714024
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44893172
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.43742247
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43207538
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41293973
60CBP_20019798_ChIP-Seq_JUKART_Human1.41293973
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41060179
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40976344
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40434448
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.40273972
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40030550
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.38665309
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38636654
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38368197
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38368197
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37489033
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.36972949
72REST_21632747_ChIP-Seq_MESCs_Mouse1.36914694
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35131081
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34821229
75P53_22387025_ChIP-Seq_ESCs_Mouse1.33565081
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.33275202
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32778802
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31339856
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.28997934
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.27545418
81OCT4_18555785_Chip-Seq_ESCs_Mouse1.27483485
82GATA3_21867929_ChIP-Seq_TH1_Mouse1.27457695
83MYC_18940864_ChIP-ChIP_HL60_Human1.26882560
84P300_18555785_Chip-Seq_ESCs_Mouse1.23504600
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23143883
86GBX2_23144817_ChIP-Seq_PC3_Human1.22658311
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21501370
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21007640
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19992701
90PHF8_20622853_ChIP-Seq_HELA_Human1.19773795
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.19659938
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.19154220
93GF1_26923725_Chip-Seq_HPCs_Mouse1.19011492
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18940667
95KLF4_18555785_Chip-Seq_ESCs_Mouse1.17459658
96AR_21909140_ChIP-Seq_LNCAP_Human1.17318541
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17232122
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17160774
99LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16892132
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16698352
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15803953
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15499760
103BCAT_22108803_ChIP-Seq_LS180_Human1.15427414
104TCF4_22108803_ChIP-Seq_LS180_Human1.15305467
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.14361995
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13672188
107TP53_18474530_ChIP-ChIP_U2OS_Human1.13366422
108FUS_26573619_Chip-Seq_HEK293_Human1.12267096
109ER_23166858_ChIP-Seq_MCF-7_Human1.11582623
110ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11369545
111TBL1_22424771_ChIP-Seq_293T_Human1.10320050
112STAT3_23295773_ChIP-Seq_U87_Human1.09378579
113P53_21459846_ChIP-Seq_SAOS-2_Human1.09227809
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09009331
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08893741
116PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08603901
117IRF1_19129219_ChIP-ChIP_H3396_Human1.08602426
118FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08394532
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08059580
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07436570
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07241645
122E2F1_18555785_Chip-Seq_ESCs_Mouse1.07170954
123CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06361336
124SOX9_26525672_Chip-Seq_HEART_Mouse1.06356316
125ETV1_20927104_ChIP-Seq_GIST48_Human1.05978689
126CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04647691
127* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04326226
128RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04156776
129NFYB_21822215_ChIP-Seq_K562_Human1.03547247
130* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03266867
131* FOXA1_25329375_ChIP-Seq_VCAP_Human1.03266867
132PU1_27457419_Chip-Seq_LIVER_Mouse1.03151784
133RUNX2_22187159_ChIP-Seq_PCA_Human1.03012899
134NFYA_21822215_ChIP-Seq_K562_Human1.02867617
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02689417
136SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01831129
137ZFX_18555785_Chip-Seq_ESCs_Mouse1.01709045
138POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01615098
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01262118
140AR_25329375_ChIP-Seq_VCAP_Human1.01178520
141* GF1B_26923725_Chip-Seq_HPCs_Mouse1.01034667
142CTCF_18555785_Chip-Seq_ESCs_Mouse1.00771507
143HNFA_21074721_ChIP-Seq_CACO-2_Human1.00423877
144RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00092755
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.99704402
146ERG_20517297_ChIP-Seq_VCAP_Human0.99579378
147* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99083694
148RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97758661
149SMAD4_21799915_ChIP-Seq_A2780_Human0.96303672
150RBPJ_21746931_ChIP-Seq_IB4_Human0.96210936
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95336386
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95032449
153NANOG_19829295_ChIP-Seq_ESCs_Human0.94594823
154SOX2_19829295_ChIP-Seq_ESCs_Human0.94594823
155LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94504970
156* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94503044
157JUN_21703547_ChIP-Seq_K562_Human0.94122222
158SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93192838
159CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92364746
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91792702
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.91514767
162FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90892911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.84507590
2MP0001929_abnormal_gametogenesis5.39140250
3MP0008877_abnormal_DNA_methylation4.71743923
4MP0000566_synostosis3.68975040
5MP0002210_abnormal_sex_determination3.66179837
6MP0008875_abnormal_xenobiotic_pharmacok3.21946684
7MP0002653_abnormal_ependyma_morphology3.19007469
8MP0002161_abnormal_fertility/fecundity3.14443457
9MP0001145_abnormal_male_reproductive2.99340776
10MP0010030_abnormal_orbit_morphology2.91252087
11MP0001984_abnormal_olfaction2.80888588
12MP0000653_abnormal_sex_gland2.65469449
13MP0005248_abnormal_Harderian_gland2.21326911
14MP0002160_abnormal_reproductive_system2.14981593
15MP0005623_abnormal_meninges_morphology2.10920541
16MP0005670_abnormal_white_adipose2.08933869
17MP0005410_abnormal_fertilization14.5413869
18MP0006292_abnormal_olfactory_placode1.94057039
19MP0001529_abnormal_vocalization1.86072631
20MP0001346_abnormal_lacrimal_gland1.84697771
21MP0002638_abnormal_pupillary_reflex1.79864657
22MP0009379_abnormal_foot_pigmentation1.72863308
23MP0002282_abnormal_trachea_morphology1.69365329
24MP0003937_abnormal_limbs/digits/tail_de1.63883328
25MP0002277_abnormal_respiratory_mucosa1.45720726
26MP0003646_muscle_fatigue1.45625910
27MP0000383_abnormal_hair_follicle1.36629320
28MP0000372_irregular_coat_pigmentation1.35343178
29MP0003890_abnormal_embryonic-extraembry1.34601363
30MP0008995_early_reproductive_senescence1.34426897
31MP0001485_abnormal_pinna_reflex1.29487365
32MP0009046_muscle_twitch1.28264912
33MP0004019_abnormal_vitamin_homeostasis1.28220336
34MP0008058_abnormal_DNA_repair1.27534793
35MP0003718_maternal_effect1.27417380
36MP0005408_hypopigmentation1.23908398
37MP0001765_abnormal_ion_homeostasis1.18677217
38MP0005389_reproductive_system_phenotype1.15582261
39MP0009780_abnormal_chondrocyte_physiolo1.15269840
40MP0002234_abnormal_pharynx_morphology1.13969992
41MP0004233_abnormal_muscle_weight1.12010439
42MP0003693_abnormal_embryo_hatching1.10446340
43MP0003938_abnormal_ear_development1.06110695
44MP0001286_abnormal_eye_development1.05374780
45MP0005187_abnormal_penis_morphology1.04100148
46MP0005646_abnormal_pituitary_gland1.02403580
47MP0002102_abnormal_ear_morphology1.00246597
48MP0010678_abnormal_skin_adnexa1.00113593
49MP0003119_abnormal_digestive_system0.98113439
50MP0003755_abnormal_palate_morphology0.96766728
51MP0003136_yellow_coat_color0.95797223
52MP0005647_abnormal_sex_gland0.94448455
53MP0003122_maternal_imprinting0.93557550
54MP0002084_abnormal_developmental_patter0.92705113
55MP0003283_abnormal_digestive_organ0.91434975
56MP0008057_abnormal_DNA_replication0.87213792
57MP0008961_abnormal_basal_metabolism0.86130645
58MP0008932_abnormal_embryonic_tissue0.83868156
59MP0000955_abnormal_spinal_cord0.83229498
60MP0003786_premature_aging0.82063424
61MP0005551_abnormal_eye_electrophysiolog0.81350461
62MP0004957_abnormal_blastocyst_morpholog0.80328780
63MP0002822_catalepsy0.80049244
64MP0000647_abnormal_sebaceous_gland0.78879785
65MP0005083_abnormal_biliary_tract0.78637568
66MP0002111_abnormal_tail_morphology0.77535254
67MP0000427_abnormal_hair_cycle0.77517450
68MP0001486_abnormal_startle_reflex0.77229360
69MP0004142_abnormal_muscle_tone0.76058291
70MP0008789_abnormal_olfactory_epithelium0.75377510
71MP0005084_abnormal_gallbladder_morpholo0.75211277
72MP0005171_absent_coat_pigmentation0.73934741
73MP0003121_genomic_imprinting0.73900860
74MP0002085_abnormal_embryonic_tissue0.73064644
75MP0005253_abnormal_eye_physiology0.72577661
76MP0001299_abnormal_eye_distance/0.72144164
77MP0004043_abnormal_pH_regulation0.72120577
78MP0003077_abnormal_cell_cycle0.71379944
79MP0005395_other_phenotype0.71271184
80MP0002928_abnormal_bile_duct0.70903225
81MP0005636_abnormal_mineral_homeostasis0.70835054
82MP0004133_heterotaxia0.68794171
83MP0006072_abnormal_retinal_apoptosis0.68248689
84MP0003878_abnormal_ear_physiology0.65115425
85MP0005377_hearing/vestibular/ear_phenot0.65115425
86MP0002736_abnormal_nociception_after0.61914501
87MP0001270_distended_abdomen0.61692919
88MP0009250_abnormal_appendicular_skeleto0.61435281
89MP0004134_abnormal_chest_morphology0.61374002
90MP0005499_abnormal_olfactory_system0.59979074
91MP0005394_taste/olfaction_phenotype0.59979074
92MP0001986_abnormal_taste_sensitivity0.56577525
93MP0006036_abnormal_mitochondrial_physio0.53117870
94MP0001293_anophthalmia0.52454143
95MP0000049_abnormal_middle_ear0.52022714
96MP0005645_abnormal_hypothalamus_physiol0.51928597
97MP0002735_abnormal_chemical_nociception0.51912881
98MP0001968_abnormal_touch/_nociception0.51710787
99MP0002557_abnormal_social/conspecific_i0.49188506
100MP0003011_delayed_dark_adaptation0.48823934
101MP0001324_abnormal_eye_pigmentation0.46911340
102MP0005391_vision/eye_phenotype0.46353259
103MP0002752_abnormal_somatic_nervous0.45700966
104MP0001119_abnormal_female_reproductive0.45553348
105MP0004742_abnormal_vestibular_system0.44973610
106MP0000631_abnormal_neuroendocrine_gland0.44750566
107MP0004036_abnormal_muscle_relaxation0.44136880
108MP0010094_abnormal_chromosome_stability0.43114432
109MP0003699_abnormal_female_reproductive0.43090767
110MP0002152_abnormal_brain_morphology0.41870358
111MP0003861_abnormal_nervous_system0.41366059
112MP0000358_abnormal_cell_content/0.40890202
113MP0006276_abnormal_autonomic_nervous0.39350776
114MP0004145_abnormal_muscle_electrophysio0.38746198
115MP0000778_abnormal_nervous_system0.38740601
116MP0002971_abnormal_brown_adipose0.38726410
117MP0001727_abnormal_embryo_implantation0.38254002
118MP0002572_abnormal_emotion/affect_behav0.37585458
119MP0006035_abnormal_mitochondrial_morpho0.37427957
120MP0002272_abnormal_nervous_system0.36413534
121MP0001764_abnormal_homeostasis0.36171195
122MP0003880_abnormal_central_pattern0.35260000
123MP0004270_analgesia0.34983766
124MP0002132_abnormal_respiratory_system0.34482860
125MP0002233_abnormal_nose_morphology0.34287334
126MP0005195_abnormal_posterior_eye0.33952175
127MP0001502_abnormal_circadian_rhythm0.33351879
128MP0002693_abnormal_pancreas_physiology0.33319756
129MP0003942_abnormal_urinary_system0.32654570
130MP0001440_abnormal_grooming_behavior0.32605895
131MP0003115_abnormal_respiratory_system0.31988592
132MP0009115_abnormal_fat_cell0.31389408
133MP0002882_abnormal_neuron_morphology0.31093014
134MP0000026_abnormal_inner_ear0.30817947
135MP0003633_abnormal_nervous_system0.30087770
136MP0009697_abnormal_copulation0.29801319
137MP0001963_abnormal_hearing_physiology0.29327723
138MP0002938_white_spotting0.29116483
139MP0001944_abnormal_pancreas_morphology0.28144744
140MP0002229_neurodegeneration0.28106085
141MP0002909_abnormal_adrenal_gland0.27863269
142MP0003634_abnormal_glial_cell0.27670593
143MP0002734_abnormal_mechanical_nocicepti0.27550108
144MP0004811_abnormal_neuron_physiology0.26923645
145MP0002109_abnormal_limb_morphology0.25876894
146MP0000534_abnormal_ureter_morphology0.25836324
147MP0002116_abnormal_craniofacial_bone0.25830249

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.74874227
2Abnormal respiratory epithelium morphology (HP:0012253)9.74874227
3Abnormal ciliary motility (HP:0012262)9.49002106
4Rhinitis (HP:0012384)8.55872762
5Chronic bronchitis (HP:0004469)7.35059296
6Nasal polyposis (HP:0100582)5.63079027
7Infertility (HP:0000789)5.45810167
8Bronchiectasis (HP:0002110)4.91628555
9Abnormality of the nasal mucosa (HP:0000433)4.56981269
10Nephronophthisis (HP:0000090)4.40572911
11Bronchitis (HP:0012387)4.12215580
12Recurrent sinusitis (HP:0011108)3.70656050
13Abnormality of the renal medulla (HP:0100957)3.37904908
14Medial flaring of the eyebrow (HP:0010747)3.35070998
15Abnormality of midbrain morphology (HP:0002418)3.34063908
16Molar tooth sign on MRI (HP:0002419)3.34063908
17Tubulointerstitial nephritis (HP:0001970)3.13607118
18Recurrent otitis media (HP:0000403)3.02577145
19Male infertility (HP:0003251)2.96885095
20Pancreatic fibrosis (HP:0100732)2.69195959
21True hermaphroditism (HP:0010459)2.60276572
22Tubular atrophy (HP:0000092)2.51901223
23Congenital primary aphakia (HP:0007707)2.48574121
24Gait imbalance (HP:0002141)2.46341285
25Abnormal spermatogenesis (HP:0008669)2.43266869
26Chronic sinusitis (HP:0011109)2.34807707
27Postaxial foot polydactyly (HP:0001830)2.25820725
28Tubulointerstitial abnormality (HP:0001969)2.25574127
29Nephrogenic diabetes insipidus (HP:0009806)2.23908591
30Congenital hepatic fibrosis (HP:0002612)2.23592275
31Fibular hypoplasia (HP:0003038)2.12315015
32Furrowed tongue (HP:0000221)2.10486314
33Pancreatic cysts (HP:0001737)2.02159752
34Stage 5 chronic kidney disease (HP:0003774)2.01475303
35Atelectasis (HP:0100750)2.00460670
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2336082
37Dynein arm defect of respiratory motile cilia (HP:0012255)12.4299080
38Absent/shortened dynein arms (HP:0200106)12.4299080
39Abnormal respiratory motile cilium physiology (HP:0012261)10.6330480
40Cystic liver disease (HP:0006706)1.98148532
41Recurrent bronchitis (HP:0002837)1.96986436
42Chronic otitis media (HP:0000389)1.95163887
43Postaxial hand polydactyly (HP:0001162)1.92490971
44Median cleft lip (HP:0000161)1.91411697
45Aplasia/Hypoplasia of the tongue (HP:0010295)1.90752926
46Genital tract atresia (HP:0001827)1.90384156
47Vaginal atresia (HP:0000148)1.88755273
48Supernumerary spleens (HP:0009799)1.88081196
49Hyperactive renin-angiotensin system (HP:0000841)1.86738993
50Aplasia/Hypoplasia of the lens (HP:0008063)1.86211283
51Gonadotropin excess (HP:0000837)1.85580673
52Facial cleft (HP:0002006)1.85409965
53Poor coordination (HP:0002370)1.84618163
54Taurodontia (HP:0000679)1.84361793
55Abnormality of permanent molar morphology (HP:0011071)1.84361793
56Abnormality of the dental root (HP:0006486)1.84361793
57Oculomotor apraxia (HP:0000657)1.81675610
58Abnormality of the renal cortex (HP:0011035)1.80319623
59Abnormal drinking behavior (HP:0030082)1.80316448
60Polydipsia (HP:0001959)1.80316448
61Aplasia/Hypoplasia of the spleen (HP:0010451)1.79339935
62Azoospermia (HP:0000027)1.77753245
63Abnormality of dentin (HP:0010299)1.73844328
64Occipital encephalocele (HP:0002085)1.73839344
65Abnormality of molar morphology (HP:0011070)1.72885134
66Abnormality of molar (HP:0011077)1.72885134
67Asplenia (HP:0001746)1.71704820
68Narrow forehead (HP:0000341)1.71517133
69Abnormality of the dental pulp (HP:0006479)1.69066091
70Chronic hepatic failure (HP:0100626)1.67522683
71Bile duct proliferation (HP:0001408)1.65221242
72Abnormal biliary tract physiology (HP:0012439)1.65221242
73Retinal dysplasia (HP:0007973)1.61374093
74Broad distal phalanx of finger (HP:0009836)1.60837840
75Holoprosencephaly (HP:0001360)1.56599827
76Abnormality of renal excretion (HP:0011036)1.56364293
77Septo-optic dysplasia (HP:0100842)1.55894333
78Prominent nasal bridge (HP:0000426)1.52518131
79Tubulointerstitial fibrosis (HP:0005576)1.51417959
80Dyschromatopsia (HP:0007641)1.49655518
81Bell-shaped thorax (HP:0001591)1.47594804
82Multicystic kidney dysplasia (HP:0000003)1.46536306
83Impulsivity (HP:0100710)1.46078592
84Short ribs (HP:0000773)1.45740677
85Bifid tongue (HP:0010297)1.45392796
86Acute necrotizing encephalopathy (HP:0006965)1.44487189
87Renal dysplasia (HP:0000110)1.39179007
88Aplasia/Hypoplasia of the fibula (HP:0006492)1.38221387
89Anencephaly (HP:0002323)1.35521466
90Decreased central vision (HP:0007663)1.35039278
91Abnormality of abdominal situs (HP:0011620)1.34974881
92Abdominal situs inversus (HP:0003363)1.34974881
93Dandy-Walker malformation (HP:0001305)1.34913649
94Constricted visual fields (HP:0001133)1.32990325
95Absent rod-and cone-mediated responses on ERG (HP:0007688)1.32776451
96Mitochondrial inheritance (HP:0001427)1.31326442
97Decreased testicular size (HP:0008734)1.31189135
98Renal salt wasting (HP:0000127)1.30859472
99Chorioretinal coloboma (HP:0000567)1.29967606
100Highly arched eyebrow (HP:0002553)1.29890017
101Bifid scrotum (HP:0000048)1.29687259
10211 pairs of ribs (HP:0000878)1.29511668
103Sclerocornea (HP:0000647)1.29313821
104Male pseudohermaphroditism (HP:0000037)1.27896183
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.27468355
106Acute encephalopathy (HP:0006846)1.27177474
107Short thorax (HP:0010306)1.25764357
108Sloping forehead (HP:0000340)1.25380426
109Preaxial hand polydactyly (HP:0001177)1.25135138
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.25123243
111Anophthalmia (HP:0000528)1.24868526
112Nephropathy (HP:0000112)1.24091904
113Abnormal urine output (HP:0012590)1.24053218
114Microglossia (HP:0000171)1.23377987
115Rib fusion (HP:0000902)1.22672896
116Specific learning disability (HP:0001328)1.20259665
117Abnormal mitochondria in muscle tissue (HP:0008316)1.19052782
118Increased hepatocellular lipid droplets (HP:0006565)1.18878784
119Polyuria (HP:0000103)1.17287586
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.16926004
121Absent epiphyses (HP:0010577)1.16926004
122Congenital, generalized hypertrichosis (HP:0004540)1.16674587
123Retinitis pigmentosa (HP:0000510)1.15071523
124Abnormality of renal resorption (HP:0011038)1.11769910
125Optic nerve hypoplasia (HP:0000609)1.09173811
126Short nail (HP:0001799)1.08749874
127Abnormality of macular pigmentation (HP:0008002)1.06700774
128Astigmatism (HP:0000483)1.06388813
129Aganglionic megacolon (HP:0002251)1.05832151
130Broad foot (HP:0001769)1.03840391
131Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.03803352
132Polycystic ovaries (HP:0000147)1.03618028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.27957078
2PDK49.27957078
3PDK26.06854788
4TESK13.74786084
5PRKD33.29059092
6BUB13.23353832
7ICK2.73258425
8PNCK2.63805488
9BCR2.31908505
10PBK2.27587569
11MAPK152.18835756
12WNK42.14820537
13STK392.06703816
14NEK11.94079570
15MAP3K41.93128804
16EPHA21.93049633
17PTK2B1.92582372
18TRIM281.78807085
19PLK31.51014170
20VRK21.43876052
21IRAK11.36949031
22MAP4K21.27025837
23ZAK1.24197114
24NME11.23704342
25FRK1.12799404
26EPHA41.07791350
27DYRK1B1.05313676
28STK241.04631949
29MKNK10.99139490
30NEK20.98763223
31DYRK30.98587938
32INSRR0.96652596
33STK380.93485503
34EPHA30.91001877
35CSNK1G20.90844794
36BRSK10.90347430
37NUAK10.90232627
38TLK10.89483479
39PDK10.85898483
40EPHB20.84973873
41MAP3K120.81274145
42MUSK0.81099053
43WNK10.80826582
44AURKB0.80759066
45EIF2AK10.79149944
46CSNK1G10.78955484
47TSSK60.76913914
48CSNK1G30.76312910
49PLK40.74946193
50FGFR20.69970738
51STK38L0.68842138
52CSNK1A1L0.68285298
53UHMK10.65779500
54LMTK20.64446704
55PRKCI0.63440216
56PINK10.62824175
57CCNB10.61979776
58LIMK10.60798520
59PAK30.59768237
60PASK0.59402879
61MAP3K20.59112067
62BMPR1B0.58350586
63ACVR1B0.57990931
64IRAK20.57248397
65STK100.56443107
66MAP2K60.56079861
67LRRK20.55001302
68ERBB20.54790182
69CDK190.54285709
70TAF10.53419549
71WNK30.52392566
72PRKCE0.51681278
73CHEK20.50342776
74STK160.49643526
75TGFBR10.48733738
76MAP2K40.48257999
77STK30.46919234
78TTK0.46651633
79EIF2AK30.45296156
80WEE10.45226452
81LATS10.45120272
82MAPKAPK30.44211725
83CDK80.43727121
84PRKCG0.42746207
85MINK10.41967690
86MAPKAPK50.41181150
87BCKDK0.39400116
88CDK30.39064579
89CASK0.38360313
90NEK60.37688195
91BRAF0.35751656
92STK40.34309867
93DYRK1A0.34196705
94ADRBK10.33894893
95CAMK1G0.33803680
96ERBB40.33655387
97PDPK10.33430235
98YES10.31083409
99NTRK20.30825039
100CHEK10.29855238
101MAP2K70.28966178
102TYRO30.28010736
103ATM0.26452135
104MKNK20.25784538
105CDC70.25053377
106BRSK20.23429374
107ERBB30.21499450
108AKT30.19769475
109PHKG10.19392318
110PHKG20.19392318
111PAK10.19389791
112PRKG10.19360868
113ATR0.19212120
114CAMK2A0.17899702
115OXSR10.17813555
116RPS6KB10.17643187
117ADRBK20.17041443
118PRKG20.16729807
119PRKAA10.15257837
120PLK10.14936599
121PKN10.12707472
122AURKA0.12587415
123PRKCQ0.12149190
124CSNK2A10.11510831
125GRK10.11190155
126DYRK20.11150298
127PRKACA0.11043662
128VRK10.10517150
129PRKACG0.10152044
130CAMK2G0.08959815
131PRKCZ0.07836905
132CAMK2D0.07739721
133PAK20.07192041
134OBSCN0.06646215
135CSNK2A20.06609640
136MAPK130.05854928
137EEF2K0.05790657
138MARK30.05545003
139CAMK2B0.05150330
140TESK20.04679752
141MST40.04227558
142PLK20.03824250
143MARK20.03666648
144MARK10.03135074
145PRKCA0.03129605
146CDK150.02783680
147TNIK0.02707133
148GSK3B0.02574574
149MTOR0.02376021
150PRKACB0.02205153
151MYLK0.02070430
152SRPK10.02063101
153CDK180.01992349
154CDK140.01891317
155RPS6KA20.01657130

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.84013918
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.70811213
3Pyruvate metabolism_Homo sapiens_hsa006203.70300981
4Basal transcription factors_Homo sapiens_hsa030222.94901481
5Propanoate metabolism_Homo sapiens_hsa006402.74427512
6Huntingtons disease_Homo sapiens_hsa050162.68016814
7Fatty acid biosynthesis_Homo sapiens_hsa000612.59761507
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59579808
9Glucagon signaling pathway_Homo sapiens_hsa049222.52829784
10Linoleic acid metabolism_Homo sapiens_hsa005912.47429368
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41987642
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.37298029
13Ribosome_Homo sapiens_hsa030102.04030924
14Cardiac muscle contraction_Homo sapiens_hsa042601.93470631
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.88577722
16Fanconi anemia pathway_Homo sapiens_hsa034601.88190097
17Histidine metabolism_Homo sapiens_hsa003401.86848476
18Phenylalanine metabolism_Homo sapiens_hsa003601.86273929
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81570404
20Selenocompound metabolism_Homo sapiens_hsa004501.81120434
21Oocyte meiosis_Homo sapiens_hsa041141.79862650
22Olfactory transduction_Homo sapiens_hsa047401.77804771
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76706204
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76280583
25Tyrosine metabolism_Homo sapiens_hsa003501.75912292
26beta-Alanine metabolism_Homo sapiens_hsa004101.72272397
27Dorso-ventral axis formation_Homo sapiens_hsa043201.72128680
28Amphetamine addiction_Homo sapiens_hsa050311.67266892
29Steroid biosynthesis_Homo sapiens_hsa001001.64223301
30Nucleotide excision repair_Homo sapiens_hsa034201.63768122
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59107367
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55847791
33Basal cell carcinoma_Homo sapiens_hsa052171.54847903
34Purine metabolism_Homo sapiens_hsa002301.54236947
35Glycerolipid metabolism_Homo sapiens_hsa005611.53086948
36Caffeine metabolism_Homo sapiens_hsa002321.51794455
37Mismatch repair_Homo sapiens_hsa034301.48319281
38Oxidative phosphorylation_Homo sapiens_hsa001901.45678644
39Collecting duct acid secretion_Homo sapiens_hsa049661.45510367
40RNA polymerase_Homo sapiens_hsa030201.38950146
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38120661
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37740676
43Sulfur metabolism_Homo sapiens_hsa009201.37634755
44Ether lipid metabolism_Homo sapiens_hsa005651.37541421
45Retinol metabolism_Homo sapiens_hsa008301.36444241
46Mineral absorption_Homo sapiens_hsa049781.36248728
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.32728044
48Non-homologous end-joining_Homo sapiens_hsa034501.31040629
49Pentose phosphate pathway_Homo sapiens_hsa000301.29842106
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27887058
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26924512
52Butanoate metabolism_Homo sapiens_hsa006501.26880254
53Insulin secretion_Homo sapiens_hsa049111.26737750
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25726037
55Folate biosynthesis_Homo sapiens_hsa007901.25681461
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24887922
57Renin secretion_Homo sapiens_hsa049241.24415241
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22916040
59Peroxisome_Homo sapiens_hsa041461.16485824
60Arachidonic acid metabolism_Homo sapiens_hsa005901.12724753
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.11616949
62Parkinsons disease_Homo sapiens_hsa050121.10440589
63Taste transduction_Homo sapiens_hsa047421.07826562
64Primary bile acid biosynthesis_Homo sapiens_hsa001201.06608933
65PPAR signaling pathway_Homo sapiens_hsa033201.06519369
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00900729
67Fructose and mannose metabolism_Homo sapiens_hsa000510.99940181
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98531295
69Alzheimers disease_Homo sapiens_hsa050100.97357731
70Cell cycle_Homo sapiens_hsa041100.95600603
71Protein export_Homo sapiens_hsa030600.92825502
72Hippo signaling pathway_Homo sapiens_hsa043900.92786575
73mRNA surveillance pathway_Homo sapiens_hsa030150.92281122
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90309828
75Glutathione metabolism_Homo sapiens_hsa004800.90000698
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89099770
77Spliceosome_Homo sapiens_hsa030400.88597346
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88114396
79Calcium signaling pathway_Homo sapiens_hsa040200.87318211
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86979293
81RNA degradation_Homo sapiens_hsa030180.85942473
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.84709034
83Base excision repair_Homo sapiens_hsa034100.84458449
84Hedgehog signaling pathway_Homo sapiens_hsa043400.81601422
85Thyroid hormone synthesis_Homo sapiens_hsa049180.80240090
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79541511
87Nitrogen metabolism_Homo sapiens_hsa009100.78887742
88Carbon metabolism_Homo sapiens_hsa012000.78327543
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77071183
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76804701
91Tryptophan metabolism_Homo sapiens_hsa003800.75798506
92Long-term potentiation_Homo sapiens_hsa047200.74081232
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71528945
94p53 signaling pathway_Homo sapiens_hsa041150.71113136
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70803964
96Circadian entrainment_Homo sapiens_hsa047130.69254532
97Synaptic vesicle cycle_Homo sapiens_hsa047210.68536255
98RNA transport_Homo sapiens_hsa030130.68064492
99Sphingolipid metabolism_Homo sapiens_hsa006000.67895299
100Pyrimidine metabolism_Homo sapiens_hsa002400.66978108
101Circadian rhythm_Homo sapiens_hsa047100.65418154
102Estrogen signaling pathway_Homo sapiens_hsa049150.64501186
103Metabolic pathways_Homo sapiens_hsa011000.64442129
104Chemical carcinogenesis_Homo sapiens_hsa052040.63944183
105Antigen processing and presentation_Homo sapiens_hsa046120.63091031
106Gastric acid secretion_Homo sapiens_hsa049710.62651173
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62270160
108Tight junction_Homo sapiens_hsa045300.61976359
109Vibrio cholerae infection_Homo sapiens_hsa051100.61973241
110DNA replication_Homo sapiens_hsa030300.61300648
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60449661
112Pancreatic secretion_Homo sapiens_hsa049720.60436615
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59489300
114Fat digestion and absorption_Homo sapiens_hsa049750.59218531
115Phototransduction_Homo sapiens_hsa047440.57977966
116Salivary secretion_Homo sapiens_hsa049700.57527680
117Arginine and proline metabolism_Homo sapiens_hsa003300.56507457
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55061440
119cAMP signaling pathway_Homo sapiens_hsa040240.53950382
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52822576
121ABC transporters_Homo sapiens_hsa020100.52028458
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51826715
123Protein digestion and absorption_Homo sapiens_hsa049740.51633771
124Axon guidance_Homo sapiens_hsa043600.50781680
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49604519
126Inositol phosphate metabolism_Homo sapiens_hsa005620.49427534
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48797137
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.47264398
129TGF-beta signaling pathway_Homo sapiens_hsa043500.46051558
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46014743
131Homologous recombination_Homo sapiens_hsa034400.45545664
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44759822
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42298902
134Glutamatergic synapse_Homo sapiens_hsa047240.41133636
135Systemic lupus erythematosus_Homo sapiens_hsa053220.40655592
136Alcoholism_Homo sapiens_hsa050340.38988807
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.38189819
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37855867
139N-Glycan biosynthesis_Homo sapiens_hsa005100.37769199
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37508824
141Fatty acid metabolism_Homo sapiens_hsa012120.37037732
142Fatty acid degradation_Homo sapiens_hsa000710.35382753
143Bile secretion_Homo sapiens_hsa049760.35282909
144Cocaine addiction_Homo sapiens_hsa050300.34840673
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.34810602
146Regulation of autophagy_Homo sapiens_hsa041400.33895644
147Fatty acid elongation_Homo sapiens_hsa000620.33416005
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31872926
149Serotonergic synapse_Homo sapiens_hsa047260.31350790
150Dopaminergic synapse_Homo sapiens_hsa047280.30948168
151Melanogenesis_Homo sapiens_hsa049160.29910392
152Morphine addiction_Homo sapiens_hsa050320.29471656
153Nicotine addiction_Homo sapiens_hsa050330.27841846
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27355414
155Wnt signaling pathway_Homo sapiens_hsa043100.26643193
156Proteasome_Homo sapiens_hsa030500.25988955

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