SP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.67765348
2nuclear pore organization (GO:0006999)4.67096068
3positive regulation of gamma-delta T cell activation (GO:0046645)4.41527733
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18514586
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.18514586
6modulation by symbiont of host immune response (GO:0052553)4.18514586
7positive regulation by symbiont of host defense response (GO:0052509)4.18514586
8modulation by symbiont of host defense response (GO:0052031)4.18514586
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18514586
10regulation of RNA export from nucleus (GO:0046831)4.03949789
11negative regulation of erythrocyte differentiation (GO:0045647)3.95953679
12mitotic sister chromatid cohesion (GO:0007064)3.92047819
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84723057
14positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.79698104
15positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.79698104
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.79698104
17dosage compensation (GO:0007549)3.76393316
18detection of molecule of bacterial origin (GO:0032490)3.66154692
19negative regulation of cell killing (GO:0031342)3.65137656
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65137656
21detection of other organism (GO:0098543)3.65132017
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59889760
23pore complex assembly (GO:0046931)3.58919262
24regulation of sister chromatid cohesion (GO:0007063)3.55617930
25regulation of histone H3-K9 methylation (GO:0051570)3.50074745
26pre-miRNA processing (GO:0031054)3.45010541
27regulation of gamma-delta T cell activation (GO:0046643)3.44151394
28* embryonic process involved in female pregnancy (GO:0060136)3.44065475
29negative regulation of histone methylation (GO:0031061)3.38895334
30regulation of histone H3-K27 methylation (GO:0061085)3.38395229
31antigen processing and presentation of endogenous antigen (GO:0019883)3.38205678
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37621960
33detection of external biotic stimulus (GO:0098581)3.36194439
34detection of bacterium (GO:0016045)3.34700521
35macrophage activation involved in immune response (GO:0002281)3.34502112
36regulation of gamma-delta T cell differentiation (GO:0045586)3.34458005
37regulation of posttranscriptional gene silencing (GO:0060147)3.30277894
38regulation of gene silencing by miRNA (GO:0060964)3.30277894
39regulation of gene silencing by RNA (GO:0060966)3.30277894
40meiotic chromosome segregation (GO:0045132)3.28020196
41positive regulation of chromosome segregation (GO:0051984)3.27227632
42replication fork processing (GO:0031297)3.26532636
43mitotic nuclear envelope disassembly (GO:0007077)3.26195117
44protein localization to kinetochore (GO:0034501)3.19802304
45DNA topological change (GO:0006265)3.19288760
46DNA duplex unwinding (GO:0032508)3.17927033
47establishment of apical/basal cell polarity (GO:0035089)3.17809593
48DNA geometric change (GO:0032392)3.15529143
49response to peptidoglycan (GO:0032494)3.15037991
50sister chromatid segregation (GO:0000819)3.13710126
51regulation of translational fidelity (GO:0006450)3.11101073
52DNA unwinding involved in DNA replication (GO:0006268)3.10502228
53regulation of B cell receptor signaling pathway (GO:0050855)3.09902588
54regulation of nucleobase-containing compound transport (GO:0032239)3.05574967
55membrane disassembly (GO:0030397)3.03889878
56nuclear envelope disassembly (GO:0051081)3.03889878
57cellular extravasation (GO:0045123)3.03646859
58response to host (GO:0075136)3.02367428
59response to host defenses (GO:0052200)3.02367428
60response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02367428
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99692942
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98472591
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.98468396
64somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98468396
65regulation of interferon-beta biosynthetic process (GO:0045357)2.97757743
66kinetochore organization (GO:0051383)2.96741707
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94858409
68heterochromatin organization (GO:0070828)2.94563653
69positive regulation of Cdc42 GTPase activity (GO:0043089)2.94561224
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.93283862
71response to host immune response (GO:0052572)2.93283862
72neutrophil activation involved in immune response (GO:0002283)2.93074415
73detection of biotic stimulus (GO:0009595)2.91446734
74mitotic sister chromatid segregation (GO:0000070)2.89232017
75chromatin assembly (GO:0031497)2.88292728
76histone mRNA catabolic process (GO:0071044)2.86775596
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84699088
78B cell receptor signaling pathway (GO:0050853)2.82247495
79regulation of integrin activation (GO:0033623)2.81499817
80antigen processing and presentation via MHC class Ib (GO:0002475)2.79345566
81positive regulation of SMAD protein import into nucleus (GO:0060391)2.78372537
82positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78207866
83cytoplasmic mRNA processing body assembly (GO:0033962)2.76063284
84mRNA stabilization (GO:0048255)2.74287905
85RNA stabilization (GO:0043489)2.74287905
86negative regulation of mRNA processing (GO:0050686)2.72602829
87response to laminar fluid shear stress (GO:0034616)2.71352018
88regulation of gene silencing (GO:0060968)2.70199610
89paraxial mesoderm development (GO:0048339)2.69921139
90protein localization to chromosome, centromeric region (GO:0071459)2.69267174
91mitotic chromosome condensation (GO:0007076)2.68493788
92mRNA cleavage (GO:0006379)2.67979180
93histone H3-K9 demethylation (GO:0033169)2.67868499
94hypotonic response (GO:0006971)2.67740848
953-UTR-mediated mRNA stabilization (GO:0070935)2.67584311
96regulation of telomere maintenance via telomerase (GO:0032210)2.65683070
97spliceosomal tri-snRNP complex assembly (GO:0000244)2.62922083
98histone H4-K12 acetylation (GO:0043983)2.62341018
99histone H3-K36 demethylation (GO:0070544)2.61577977
100determination of adult lifespan (GO:0008340)2.60659856
101regulation of NFAT protein import into nucleus (GO:0051532)2.60282545
102leukocyte aggregation (GO:0070486)2.60091258
103mRNA transport (GO:0051028)2.59023847
104negative regulation of RNA splicing (GO:0033119)2.58188310
105negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.58145165
106positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57999421
107regulation of necroptotic process (GO:0060544)2.56280003
108response to muramyl dipeptide (GO:0032495)2.55871643
109germinal center formation (GO:0002467)2.55106329
110regulation of stem cell maintenance (GO:2000036)2.54318892
111regulation of spindle organization (GO:0090224)2.53815670
112hepatocyte apoptotic process (GO:0097284)2.53261947
113mitotic metaphase plate congression (GO:0007080)2.53009064
114formation of translation preinitiation complex (GO:0001731)2.52812795
115response to interleukin-15 (GO:0070672)2.52508071
116proline biosynthetic process (GO:0006561)2.52349380
117phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.52124120
118* trophectodermal cell differentiation (GO:0001829)2.51963099
119DNA conformation change (GO:0071103)2.51867388
120* embryonic placenta development (GO:0001892)2.51684715
121nuclear envelope organization (GO:0006998)2.51579743
122negative regulation of mRNA metabolic process (GO:1903312)2.50753687
123mitotic G1 DNA damage checkpoint (GO:0031571)2.50289130
124establishment of monopolar cell polarity (GO:0061162)2.48945529
125establishment or maintenance of monopolar cell polarity (GO:0061339)2.48945529
126nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.47931262
127regulation of mitotic spindle organization (GO:0060236)2.47833255
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47348560
129negative regulation of lymphocyte mediated immunity (GO:0002707)2.47109977
130face development (GO:0060324)2.46975305
131regulation of DNA endoreduplication (GO:0032875)2.46459440
132regulation of double-strand break repair (GO:2000779)2.46434109
133regulation of SMAD protein import into nucleus (GO:0060390)2.46387904
134histone lysine demethylation (GO:0070076)2.44579871
135DNA strand renaturation (GO:0000733)2.43445690
136regulation of protein polyubiquitination (GO:1902914)2.43052949
137regulation of hippo signaling (GO:0035330)2.42472770
138IMP biosynthetic process (GO:0006188)2.41224300
139metaphase plate congression (GO:0051310)2.40770908
140positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40494064
141kinetochore assembly (GO:0051382)2.40146510
142positive thymic T cell selection (GO:0045059)2.40012857
143histone demethylation (GO:0016577)2.39339366
144regulation of helicase activity (GO:0051095)2.39193033
145production of molecular mediator involved in inflammatory response (GO:0002532)2.38283510
146iron ion import (GO:0097286)2.38230981
147telomere maintenance via semi-conservative replication (GO:0032201)2.37982265
148negative thymic T cell selection (GO:0045060)2.36911981
149macrophage activation (GO:0042116)2.36875738
150regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.36822981
151positive regulation of interferon-alpha production (GO:0032727)2.36791079
152negative regulation of myotube differentiation (GO:0010832)2.36259421
153regulation of chromatin silencing (GO:0031935)2.36187747
154regulation of DNA damage checkpoint (GO:2000001)2.35801487
155mitotic recombination (GO:0006312)2.35373346
156G1 DNA damage checkpoint (GO:0044783)2.35284097
157regulation of mRNA stability (GO:0043488)2.34206582
158apoptotic process involved in morphogenesis (GO:0060561)2.33587494
159JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.33239630
160peptidyl-threonine phosphorylation (GO:0018107)2.33069957
161positive regulation of cellular amide metabolic process (GO:0034250)2.32475809
162DNA strand elongation involved in DNA replication (GO:0006271)2.32154182
163establishment of RNA localization (GO:0051236)2.31259479
164megakaryocyte development (GO:0035855)2.30973812
165T cell selection (GO:0045058)2.30259850
166positive regulation of protein import into nucleus, translocation (GO:0033160)2.29741647
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.28846468
168regulation of leukocyte degranulation (GO:0043300)2.28831418
169peptidyl-threonine modification (GO:0018210)2.28633167
170microglial cell activation (GO:0001774)2.28585589
171negative regulation of interleukin-12 production (GO:0032695)2.28104784
172negative regulation of DNA repair (GO:0045738)2.26862418
173negative T cell selection (GO:0043383)2.26323232
174thymic T cell selection (GO:0045061)2.26027622
175negative regulation of T cell mediated immunity (GO:0002710)2.24416183
176positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.23791699
177response to epidermal growth factor (GO:0070849)2.22562456
178respiratory burst (GO:0045730)2.20920112
179positive T cell selection (GO:0043368)2.20282793
180protein export from nucleus (GO:0006611)2.19830318
181positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.18857146
182protein localization to endosome (GO:0036010)2.17404557
183positive regulation of B cell differentiation (GO:0045579)2.17143881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.44764650
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60991179
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19864341
4* EGR1_19374776_ChIP-ChIP_THP-1_Human3.18539566
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.90848411
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77347467
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67467864
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.45690459
9MYC_22102868_ChIP-Seq_BL_Human2.44237095
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43638406
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39216101
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39125840
13* MYC_18555785_ChIP-Seq_MESCs_Mouse2.36265825
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.34961685
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32330405
16GATA1_22025678_ChIP-Seq_K562_Human2.26415691
17* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11351088
18* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11351088
19* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11351088
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09800534
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97077038
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.96317809
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95108212
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.92501334
25* TP63_19390658_ChIP-ChIP_HaCaT_Human1.90151748
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79033624
27SPI1_23127762_ChIP-Seq_K562_Human1.77593467
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.77504585
29AR_21909140_ChIP-Seq_LNCAP_Human1.76213216
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73178555
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72189436
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.72175239
33VDR_21846776_ChIP-Seq_THP-1_Human1.69669440
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69610651
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67907438
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67905959
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66498651
38SPI1_23547873_ChIP-Seq_NB4_Human1.64355256
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62915934
40* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62847501
41RUNX_20019798_ChIP-Seq_JUKART_Human1.61119397
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60348759
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59471165
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56258123
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55807412
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.55612736
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55148243
48CLOCK_20551151_ChIP-Seq_293T_Human1.54839790
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50926718
50* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48830523
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47652169
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45385111
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44390962
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41156687
55TCF7_22412390_ChIP-Seq_EML_Mouse1.40811912
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40775578
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39864827
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39643039
59* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39629111
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.38902724
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.38304421
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37121851
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.35817045
64* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35587006
65GATA1_19941826_ChIP-Seq_K562_Human1.35540026
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34934106
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34620930
68* RACK7_27058665_Chip-Seq_MCF-7_Human1.34496615
69* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33964865
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.31502954
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.30499660
72* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29575330
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28988604
74* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28297978
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27918898
76* PU_27001747_Chip-Seq_BMDM_Mouse1.27832759
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27333973
78* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26810794
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24999762
80* NANOG_21062744_ChIP-ChIP_HESCs_Human1.22961295
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.21607622
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20728710
83* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20503325
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20215245
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19081763
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19081763
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18670299
88* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17998339
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17798034
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16882499
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16695476
92GATA2_19941826_ChIP-Seq_K562_Human1.16098302
93* MYB_26560356_Chip-Seq_TH1_Human1.15865954
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15651529
95* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15249322
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14950075
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.14943976
98* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13379881
99MAF_26560356_Chip-Seq_TH2_Human1.13366830
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.13202577
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12761206
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11886306
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11073460
104KDM5A_27292631_Chip-Seq_BREAST_Human1.10889759
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10502362
106* MAF_26560356_Chip-Seq_TH1_Human1.10427747
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10241497
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09339641
109KDM2B_26808549_Chip-Seq_K562_Human1.09263362
110TFEB_21752829_ChIP-Seq_HELA_Human1.08040922
111CHD1_26751641_Chip-Seq_LNCaP_Human1.07619157
112* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07568133
113* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07265162
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07234898
115BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06128458
116* UTX_26944678_Chip-Seq_JUKART_Human1.05406064
117* MYB_26560356_Chip-Seq_TH2_Human1.05185968
118POU5F1_16518401_ChIP-PET_MESCs_Mouse1.03684520
119* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03121987
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02608273
121* KDM2B_26808549_Chip-Seq_DND41_Human1.02406635
122* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02177940
123NCOR1_26117541_ChIP-Seq_K562_Human1.02143540
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01446742
125* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01413998
126MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01134390
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00808279
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00545937
129MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00074532
130ELK1_19687146_ChIP-ChIP_HELA_Human0.99353087
131* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99117136
132VDR_24787735_ChIP-Seq_THP-1_Human0.98984719
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98588276
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96903085
135SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96783589
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96671589
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96331764
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95458623
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95214789
140* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94996380
141PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94754460
142SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94393068
143IRF8_22096565_ChIP-ChIP_GC-B_Human0.93625498
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92529106
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.92202676
146* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91935171
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91069348
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90476578
149GATA6_25053715_ChIP-Seq_YYC3_Human0.90216008
150CIITA_25753668_ChIP-Seq_RAJI_Human0.90048028
151GATA3_27048872_Chip-Seq_THYMUS_Human0.89232296
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89168860
153SCL_19346495_ChIP-Seq_HPC-7_Human0.88921724
154ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88799311
155PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88106827
156SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87486575
157FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87366632
158VDR_24763502_ChIP-Seq_THP-1_Human0.86953584
159* XRN2_22483619_ChIP-Seq_HELA_Human0.86716977
160* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86036835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.50144246
2MP0010352_gastrointestinal_tract_polyps2.98392242
3MP0010094_abnormal_chromosome_stability2.57390507
4MP0005451_abnormal_body_composition2.37427446
5MP0009278_abnormal_bone_marrow2.37023855
6MP0003303_peritoneal_inflammation2.29694704
7MP0005076_abnormal_cell_differentiation2.18978774
8MP0003724_increased_susceptibility_to2.18473028
9MP0003111_abnormal_nucleus_morphology2.17607549
10MP0003436_decreased_susceptibility_to2.10933440
11MP0004957_abnormal_blastocyst_morpholog2.07404803
12MP0003705_abnormal_hypodermis_morpholog2.06859020
13MP0001835_abnormal_antigen_presentation2.04615483
14MP0003077_abnormal_cell_cycle2.03030407
15MP0010030_abnormal_orbit_morphology2.01309324
16MP0002009_preneoplasia1.99185099
17MP0003191_abnormal_cellular_cholesterol1.96277841
18MP0010307_abnormal_tumor_latency1.94553260
19MP0005409_darkened_coat_color1.92507892
20MP0003693_abnormal_embryo_hatching1.89914264
21MP0002396_abnormal_hematopoietic_system1.86742638
22MP0008260_abnormal_autophagy1.71394045
23* MP0004197_abnormal_fetal_growth/weight/1.64286587
24MP0004947_skin_inflammation1.63766363
25* MP0002086_abnormal_extraembryonic_tissu1.62294577
26MP0000350_abnormal_cell_proliferation1.58985522
27MP0003941_abnormal_skin_development1.58762115
28MP0004381_abnormal_hair_follicle1.58229371
29MP0003091_abnormal_cell_migration1.56450270
30MP0005380_embryogenesis_phenotype1.55499537
31MP0001672_abnormal_embryogenesis/_devel1.55499537
32MP0003566_abnormal_cell_adhesion1.53598680
33MP0002419_abnormal_innate_immunity1.52760803
34MP0008007_abnormal_cellular_replicative1.51815254
35MP0003890_abnormal_embryonic-extraembry1.50962495
36MP0002084_abnormal_developmental_patter1.48585259
37MP0001800_abnormal_humoral_immune1.47548088
38MP0001730_embryonic_growth_arrest1.47312256
39MP0004808_abnormal_hematopoietic_stem1.47242024
40MP0001545_abnormal_hematopoietic_system1.46835115
41MP0005397_hematopoietic_system_phenotyp1.46835115
42MP0003984_embryonic_growth_retardation1.46502986
43MP0008058_abnormal_DNA_repair1.45813982
44MP0002088_abnormal_embryonic_growth/wei1.45311023
45MP0000685_abnormal_immune_system1.44550311
46MP0003567_abnormal_fetal_cardiomyocyte1.42598434
47MP0002166_altered_tumor_susceptibility1.41371907
48MP0001697_abnormal_embryo_size1.39739235
49MP0000490_abnormal_crypts_of1.36921029
50* MP0002085_abnormal_embryonic_tissue1.35672232
51MP0002877_abnormal_melanocyte_morpholog1.34653187
52MP0005025_abnormal_response_to1.34330549
53MP0000858_altered_metastatic_potential1.32939422
54MP0009053_abnormal_anal_canal1.32661197
55MP0003453_abnormal_keratinocyte_physiol1.32327164
56MP0004264_abnormal_extraembryonic_tissu1.30567749
57MP0005387_immune_system_phenotype1.29507490
58MP0001790_abnormal_immune_system1.29507490
59MP0002420_abnormal_adaptive_immunity1.27875571
60MP0001819_abnormal_immune_cell1.26888069
61MP0010155_abnormal_intestine_physiology1.26663911
62MP0001851_eye_inflammation1.26037153
63MP0002452_abnormal_antigen_presenting1.24398918
64MP0005000_abnormal_immune_tolerance1.24279683
65MP0010234_abnormal_vibrissa_follicle1.22717018
66MP0003786_premature_aging1.20559515
67MP0002006_tumorigenesis1.20152459
68* MP0001293_anophthalmia1.18825153
69MP0002723_abnormal_immune_serum1.18617876
70MP0005666_abnormal_adipose_tissue1.16961755
71MP0000516_abnormal_urinary_system1.14840162
72MP0005367_renal/urinary_system_phenotyp1.14840162
73MP0005023_abnormal_wound_healing1.13823495
74MP0003300_gastrointestinal_ulcer1.12937746
75MP0008877_abnormal_DNA_methylation1.12790790
76MP0000716_abnormal_immune_system1.12589139
77MP0005248_abnormal_Harderian_gland1.12194130
78MP0003221_abnormal_cardiomyocyte_apopto1.12134070
79MP0003656_abnormal_erythrocyte_physiolo1.10804679
80MP0005464_abnormal_platelet_physiology1.10163957
81MP0001915_intracranial_hemorrhage1.08987371
82MP0002060_abnormal_skin_morphology1.08132923
83MP0008995_early_reproductive_senescence1.06180860
84MP0002080_prenatal_lethality1.05821072
85MP0002998_abnormal_bone_remodeling1.05773007
86MP0000733_abnormal_muscle_development1.04637637
87MP0001533_abnormal_skeleton_physiology1.01996623
88MP0003763_abnormal_thymus_physiology1.01986101
89MP0000432_abnormal_head_morphology1.01771861
90MP0002429_abnormal_blood_cell1.01542881
91MP0008932_abnormal_embryonic_tissue1.01325305
92MP0002925_abnormal_cardiovascular_devel1.00332551
93MP0003172_abnormal_lysosome_physiology0.99549301
94MP0003935_abnormal_craniofacial_develop0.99477860
95MP0000569_abnormal_digit_pigmentation0.99253442
96MP0003119_abnormal_digestive_system0.99098798
97MP0002019_abnormal_tumor_incidence0.98689773
98MP0006054_spinal_hemorrhage0.98051928
99MP0003123_paternal_imprinting0.97903126
100MP0001873_stomach_inflammation0.97668310
101MP0009333_abnormal_splenocyte_physiolog0.97180714
102MP0005171_absent_coat_pigmentation0.96726709
103MP0003121_genomic_imprinting0.96238601
104MP0003866_abnormal_defecation0.95661921
105MP0004883_abnormal_blood_vessel0.95499846
106MP0005621_abnormal_cell_physiology0.95102558
107MP0009115_abnormal_fat_cell0.94687005
108MP0003183_abnormal_peptide_metabolism0.92305817
109MP0000703_abnormal_thymus_morphology0.91796180
110MP0001849_ear_inflammation0.91645703
111MP0003828_pulmonary_edema0.90944848
112MP0002111_abnormal_tail_morphology0.89393982
113MP0002697_abnormal_eye_size0.89056691
114MP0009703_decreased_birth_body0.88512551
115MP0009785_altered_susceptibility_to0.87261308
116MP0002249_abnormal_larynx_morphology0.86840842
117MP0003937_abnormal_limbs/digits/tail_de0.85178910
118MP0000371_diluted_coat_color0.84773812
119MP0000313_abnormal_cell_death0.84309894
120MP0004233_abnormal_muscle_weight0.84297403
121MP0003045_fibrosis0.84234326
122MP0002282_abnormal_trachea_morphology0.84175079
123MP0002796_impaired_skin_barrier0.83827831
124MP0002098_abnormal_vibrissa_morphology0.83763100
125MP0001216_abnormal_epidermal_layer0.83305140
126* MP0002398_abnormal_bone_marrow0.83259963
127MP0003448_altered_tumor_morphology0.82553569
128MP0000377_abnormal_hair_follicle0.82052616
129MP0005058_abnormal_lysosome_morphology0.81893006
130MP0000383_abnormal_hair_follicle0.81833957
131MP0000428_abnormal_craniofacial_morphol0.80461904
132MP0005164_abnormal_response_to0.80420766
133MP0005501_abnormal_skin_physiology0.80043273
134MP0010630_abnormal_cardiac_muscle0.79994078
135MP0000689_abnormal_spleen_morphology0.79927479
136MP0010678_abnormal_skin_adnexa0.79778736
137MP0005275_abnormal_skin_tensile0.79745009
138MP0005375_adipose_tissue_phenotype0.79511413
139MP0000537_abnormal_urethra_morphology0.79378818
140* MP0002092_abnormal_eye_morphology0.79358035
141MP0003943_abnormal_hepatobiliary_system0.78425632
142MP0001845_abnormal_inflammatory_respons0.78278784
143MP0002722_abnormal_immune_system0.78121907
144MP0004185_abnormal_adipocyte_glucose0.78027147
145MP0005174_abnormal_tail_pigmentation0.77602116
146MP0005508_abnormal_skeleton_morphology0.77480472
147MP0003755_abnormal_palate_morphology0.77412747
148MP0002405_respiratory_system_inflammati0.75324941
149MP0008438_abnormal_cutaneous_collagen0.75244870
150MP0003115_abnormal_respiratory_system0.75155502
151MP0001286_abnormal_eye_development0.74251520
152MP0000465_gastrointestinal_hemorrhage0.71854093
153MP0001784_abnormal_fluid_regulation0.71515698

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.43474854
2Volvulus (HP:0002580)3.62388882
3Recurrent bacterial skin infections (HP:0005406)3.37419631
4Recurrent abscess formation (HP:0002722)3.32308939
5Spontaneous hematomas (HP:0007420)2.92151104
6Rib fusion (HP:0000902)2.87460904
7Short 4th metacarpal (HP:0010044)2.83622088
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.83622088
9Abnormality of the fingertips (HP:0001211)2.81795444
10Increased IgE level (HP:0003212)2.67835487
11Ulnar bowing (HP:0003031)2.64389466
12Gingivitis (HP:0000230)2.59261165
13Hypochromic microcytic anemia (HP:0004840)2.58938767
14Selective tooth agenesis (HP:0001592)2.56323237
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54388329
16Ankyloglossia (HP:0010296)2.50761093
17Cellulitis (HP:0100658)2.50417658
18Neoplasm of the oral cavity (HP:0100649)2.48843019
19Lip pit (HP:0100267)2.48534379
20Astrocytoma (HP:0009592)2.48471535
21Abnormality of the astrocytes (HP:0100707)2.48471535
22Intestinal fistula (HP:0100819)2.47968281
23Short humerus (HP:0005792)2.43291397
24Recurrent gram-negative bacterial infections (HP:0005420)2.41459293
25Chromsome breakage (HP:0040012)2.40690540
26Abnormality of the nasal septum (HP:0000419)2.40526703
27Facial hemangioma (HP:0000329)2.38929912
28Abnormality of macrophages (HP:0004311)2.38920437
29Asymmetry of the thorax (HP:0001555)2.37536480
30Basal cell carcinoma (HP:0002671)2.36298563
31Colitis (HP:0002583)2.36195936
32Medulloblastoma (HP:0002885)2.32872688
33Ependymoma (HP:0002888)2.29084251
34Viral hepatitis (HP:0006562)2.28318303
35Myositis (HP:0100614)2.27975888
36Orchitis (HP:0100796)2.27659564
37Long eyelashes (HP:0000527)2.27186094
38Rectovaginal fistula (HP:0000143)2.26639568
39Rectal fistula (HP:0100590)2.26639568
40Aplasia/hypoplasia of the humerus (HP:0006507)2.24843900
41Colon cancer (HP:0003003)2.23897443
42Recurrent viral infections (HP:0004429)2.23123229
43Flat acetabular roof (HP:0003180)2.21663057
44Gastrointestinal infarctions (HP:0005244)2.20180383
45Papillary thyroid carcinoma (HP:0002895)2.20110447
46Metaphyseal cupping (HP:0003021)2.19718811
47Deviation of the thumb (HP:0009603)2.19667056
48Recurrent fungal infections (HP:0002841)2.18110605
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17434553
50Abnormality of oral frenula (HP:0000190)2.16612015
51Ectopic kidney (HP:0000086)2.14053316
52T lymphocytopenia (HP:0005403)2.12022590
53Recurrent skin infections (HP:0001581)2.11378638
54Cerebral aneurysm (HP:0004944)2.10611035
55Glioma (HP:0009733)2.10123325
56Proximal placement of thumb (HP:0009623)2.09313532
57Pustule (HP:0200039)2.09264693
58Curly hair (HP:0002212)2.07903325
59Osteomyelitis (HP:0002754)2.05642715
60Abnormality of the 4th metacarpal (HP:0010012)2.04751025
61Subacute progressive viral hepatitis (HP:0006572)2.04181278
62Broad face (HP:0000283)2.03821740
63Gastrointestinal inflammation (HP:0004386)2.02653960
64Inflammation of the large intestine (HP:0002037)1.98190814
65Gastrointestinal carcinoma (HP:0002672)1.97814726
66Malignant gastrointestinal tract tumors (HP:0006749)1.97814726
67Squamous cell carcinoma (HP:0002860)1.97079946
68Fatigue (HP:0012378)1.96894218
69Absent radius (HP:0003974)1.96740305
70Polycythemia (HP:0001901)1.94519169
71Biliary tract neoplasm (HP:0100574)1.93366265
72Meningitis (HP:0001287)1.93002670
73Supernumerary ribs (HP:0005815)1.92567754
74Increased nuchal translucency (HP:0010880)1.92129001
75Urethral obstruction (HP:0000796)1.91434665
76Retrobulbar optic neuritis (HP:0100654)1.90603584
77Optic neuritis (HP:0100653)1.90603584
78Alopecia of scalp (HP:0002293)1.90355650
79Periodontitis (HP:0000704)1.90334714
80Shawl scrotum (HP:0000049)1.90005028
81Broad thumb (HP:0011304)1.89579216
82Vaginal fistula (HP:0004320)1.85554050
83Rhabdomyosarcoma (HP:0002859)1.85505918
84Spinal cord lesions (HP:0100561)1.85458072
85Syringomyelia (HP:0003396)1.85458072
86Deep philtrum (HP:0002002)1.85313897
87Absent thumb (HP:0009777)1.84501356
88Increased number of teeth (HP:0011069)1.83912635
89Germ cell neoplasia (HP:0100728)1.83443742
90Abnormal delayed hypersensitivity skin test (HP:0002963)1.83127058
91Abnormality of T cell number (HP:0011839)1.82358545
92Leiomyosarcoma (HP:0100243)1.81674934
93Uterine leiomyosarcoma (HP:0002891)1.81674934
94Keratoconjunctivitis sicca (HP:0001097)1.81653471
95Neonatal hypoglycemia (HP:0001998)1.81290802
96Impulsivity (HP:0100710)1.79605661
97Arterial thrombosis (HP:0004420)1.78985807
98Chest pain (HP:0100749)1.78941920
99Abnormal number of incisors (HP:0011064)1.78913120
100Acute myeloid leukemia (HP:0004808)1.78741022
101Hypoplastic labia majora (HP:0000059)1.78692148
102Abnormal hemoglobin (HP:0011902)1.78524623
103Dislocated radial head (HP:0003083)1.77993395
104Hypochromic anemia (HP:0001931)1.77909623
105Right ventricular cardiomyopathy (HP:0011663)1.77783186
106Mediastinal lymphadenopathy (HP:0100721)1.77780535
107Poikiloderma (HP:0001029)1.76752869
108Absent forearm bone (HP:0003953)1.76656519
109Aplasia involving forearm bones (HP:0009822)1.76656519
110Urticaria (HP:0001025)1.76610280
111Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75866293
112Dysmetric saccades (HP:0000641)1.75340850
113Recurrent cutaneous fungal infections (HP:0011370)1.75275305
114Chronic mucocutaneous candidiasis (HP:0002728)1.75275305
115Skull defect (HP:0001362)1.74716561
116Micronodular cirrhosis (HP:0001413)1.74132928
117Missing ribs (HP:0000921)1.73966460
118Heterotopia (HP:0002282)1.73700959
119Atresia of the external auditory canal (HP:0000413)1.73652308
120Arterial tortuosity (HP:0005116)1.73629839
121Segmental peripheral demyelination/remyelination (HP:0003481)1.73443303
122Patellar aplasia (HP:0006443)1.72638565
123Bladder neoplasm (HP:0009725)1.71696143
124Bladder carcinoma (HP:0002862)1.71696143
125Dilatation of the ascending aorta (HP:0005111)1.71293779
126Abnormality of chromosome stability (HP:0003220)1.71223533
127Abnormality of the peritoneum (HP:0002585)1.71083933
128Sparse lateral eyebrow (HP:0005338)1.70807380
129Abnormal foot bone ossification (HP:0010675)1.69913689
130Prolonged bleeding time (HP:0003010)1.69559209
131Slow saccadic eye movements (HP:0000514)1.69204361
132Prominent nose (HP:0000448)1.68881294
133Myelodysplasia (HP:0002863)1.68665943
134Peritonitis (HP:0002586)1.68324927
135Supernumerary bones of the axial skeleton (HP:0009144)1.68313249
136Neoplasm of striated muscle (HP:0009728)1.67698552
137Coarse hair (HP:0002208)1.67463388
138IgA deficiency (HP:0002720)1.66895356
139Esophageal atresia (HP:0002032)1.66764877
140Malnutrition (HP:0004395)1.66212085
141Rectal prolapse (HP:0002035)1.65137033
142Narrow palate (HP:0000189)1.64722842
143Increased connective tissue (HP:0009025)1.64673087
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.64169490
145Osteolytic defects of the hand bones (HP:0009699)1.64169490
146Vertebral fusion (HP:0002948)1.64053717
147Cutaneous melanoma (HP:0012056)1.63992457
148Vasculitis (HP:0002633)1.63745829
149Abnormality of the labia minora (HP:0012880)1.63744811
150Gingival bleeding (HP:0000225)1.63468371
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.63366897
152Gastrointestinal atresia (HP:0002589)1.63021154
153Disproportionate tall stature (HP:0001519)1.62610333
154Persistence of primary teeth (HP:0006335)1.62291234
155Mitral valve prolapse (HP:0001634)1.61727513
156Macroorchidism (HP:0000053)1.60924009
157Abnormal vertebral ossification (HP:0100569)1.60492524
158Aplasia/Hypoplasia of the patella (HP:0006498)1.60334765
159Abnormality of the labia majora (HP:0012881)1.60184627
160Abnormality of the ileum (HP:0001549)1.60168662
161Ankle contracture (HP:0006466)1.60054494
162Aneurysm (HP:0002617)1.59873086
163Sandal gap (HP:0001852)1.59491658
164Obstructive lung disease (HP:0006536)1.58971861
165Chronic obstructive pulmonary disease (HP:0006510)1.58971861
166Abnormality of the radial head (HP:0003995)1.58448932
167Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58394399
168Vertebral hypoplasia (HP:0008417)1.58394399
169Abnormality of the left ventricular outflow tract (HP:0011103)1.58264615
170Subaortic stenosis (HP:0001682)1.58264615
171Blepharitis (HP:0000498)1.57728720
172Broad palm (HP:0001169)1.56446077
173Low anterior hairline (HP:0000294)1.56187077
174Milia (HP:0001056)1.55657028
175Anal stenosis (HP:0002025)1.55182935
176Depressed nasal tip (HP:0000437)1.54069618
177Skin tags (HP:0010609)1.53748974
178Abnormal platelet volume (HP:0011876)1.53242917
179Transitional cell carcinoma of the bladder (HP:0006740)1.53191507
180Cutis marmorata (HP:0000965)1.52138239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.13561851
2PRPF4B3.19023046
3RIPK42.97681062
4SMG12.51411336
5LATS12.48613663
6CDC72.41627073
7ICK2.38718457
8MAP3K102.36093360
9ERN12.20024342
10CDK61.95186433
11DDR21.95125964
12EEF2K1.94886625
13STK31.93088072
14MAP2K31.88488124
15NEK21.87701317
16STK101.84769586
17MAP3K21.77214975
18EPHA21.75269610
19PIM11.72133613
20CDK71.67855812
21RPS6KB21.66868889
22KSR21.66503214
23BLK1.63706949
24MAP3K141.54510234
25IRAK41.53073164
26MAP3K131.48571185
27TRPM71.44900485
28STK41.44887350
29MKNK11.44456355
30PDGFRA1.39567790
31BRD41.36672531
32CDK41.35312050
33PKN21.33313363
34MAP4K11.30631680
35BMX1.29441116
36CSK1.28570031
37TTK1.25570087
38ZAP701.23739924
39MTOR1.23027669
40EPHB11.22262288
41WEE11.19482648
42JAK11.18640154
43* ATR1.16727029
44SGK31.15888201
45FGFR31.13697933
46CHEK21.13466766
47YES11.12545172
48CAMK1D1.10580038
49MAP3K11.10283563
50FRK1.08867337
51BTK1.08685100
52NLK1.08602189
53MKNK21.07095627
54CHUK1.05816893
55MST1R1.04954747
56CHEK11.04918059
57RPS6KA41.03803876
58SRPK11.02393301
59MAP3K61.02088047
60PLK11.01781585
61ACVR1B1.01547170
62WNK11.00744551
63RIPK11.00092965
64AURKB0.99940225
65HCK0.99791376
66ZAK0.98536383
67PASK0.97895313
68MARK20.97277295
69TRIB30.96929447
70JAK20.96152222
71MATK0.95936776
72MAPK150.95159806
73* ATM0.93450469
74FLT30.92374247
75BRSK20.91804303
76MAP3K70.91755499
77ALK0.90708357
78MELK0.88254867
79GRK60.88215145
80SGK20.86842752
81TYRO30.86634171
82SIK30.85300668
83PDGFRB0.85281944
84PTK60.84640901
85JAK30.84384822
86TTN0.82145584
87FGR0.81404304
88CDK90.81211016
89BMPR20.80182270
90HIPK20.80024920
91FGFR20.79975072
92CDK20.79899307
93DYRK1B0.79203733
94MAP3K80.78344043
95TGFBR20.77834768
96CDC42BPA0.77029644
97LRRK20.76413467
98TGFBR10.74882047
99FGFR10.74281891
100PAK40.73320082
101DYRK30.73072309
102RET0.72465429
103NUAK10.72064849
104STK38L0.70392307
105AKT30.69827926
106KSR10.69699963
107FES0.69187591
108NEK90.67564177
109SIK10.67353509
110IRAK10.67173745
111PRKD20.66447952
112SCYL20.66402184
113IKBKE0.66053478
114STK240.65798358
115PAK20.65712109
116GSK3A0.63184567
117RPS6KC10.62288483
118RPS6KL10.62288483
119TAOK10.62198552
120RAF10.61153739
121PDPK10.60995900
122PIK3CG0.59504457
123ERBB30.58974558
124MET0.58584697
125RPS6KA60.57516574
126SYK0.57429444
127CAMK1G0.56578335
128IKBKB0.56342246
129IRAK20.55770968
130DMPK0.55439019
131PDK10.53125626
132MAP3K30.52984964
133* CDK10.52075322
134* MAPK10.51984865
135PLK30.51414165
136MARK30.51268084
137CSNK1D0.50352863
138TYK20.50175211
139MAPK140.49269752
140MAP3K110.48626749
141CLK10.48404703
142FGFR40.46897597
143PRKAA20.46463958
144IRAK30.46304141
145NEK60.46005552
146AKT10.45908716
147MAPK110.43834588
148LYN0.43504501
149LCK0.42210629
150CSF1R0.41759295
151RPS6KA20.40475808

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.11808303
2DNA replication_Homo sapiens_hsa030302.79129140
3Base excision repair_Homo sapiens_hsa034102.47871799
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18561671
5RNA transport_Homo sapiens_hsa030132.14943967
6Cell cycle_Homo sapiens_hsa041102.14798223
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09559698
8mRNA surveillance pathway_Homo sapiens_hsa030152.00458764
9Spliceosome_Homo sapiens_hsa030401.99846825
10One carbon pool by folate_Homo sapiens_hsa006701.95433552
11Adherens junction_Homo sapiens_hsa045201.89043815
12Fanconi anemia pathway_Homo sapiens_hsa034601.75185847
13p53 signaling pathway_Homo sapiens_hsa041151.74681484
14Renal cell carcinoma_Homo sapiens_hsa052111.72268116
15MicroRNAs in cancer_Homo sapiens_hsa052061.71065748
16Nucleotide excision repair_Homo sapiens_hsa034201.71000216
17Homologous recombination_Homo sapiens_hsa034401.63479693
18* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.57204132
19Small cell lung cancer_Homo sapiens_hsa052221.57138587
20Notch signaling pathway_Homo sapiens_hsa043301.56980769
21Non-homologous end-joining_Homo sapiens_hsa034501.56400184
22Viral carcinogenesis_Homo sapiens_hsa052031.42004587
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41551956
24Lysine degradation_Homo sapiens_hsa003101.40385652
25Chronic myeloid leukemia_Homo sapiens_hsa052201.39968473
26Hippo signaling pathway_Homo sapiens_hsa043901.38343787
27Herpes simplex infection_Homo sapiens_hsa051681.37200885
28Basal cell carcinoma_Homo sapiens_hsa052171.36510360
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30890717
30* TGF-beta signaling pathway_Homo sapiens_hsa043501.30249703
31RNA degradation_Homo sapiens_hsa030181.28387596
32Fatty acid biosynthesis_Homo sapiens_hsa000611.25336298
33Tuberculosis_Homo sapiens_hsa051521.22140683
34Systemic lupus erythematosus_Homo sapiens_hsa053221.21994811
35Primary immunodeficiency_Homo sapiens_hsa053401.21451181
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.20854071
37Glioma_Homo sapiens_hsa052141.18618500
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18456791
39ErbB signaling pathway_Homo sapiens_hsa040121.18237612
40Staphylococcus aureus infection_Homo sapiens_hsa051501.18231737
41mTOR signaling pathway_Homo sapiens_hsa041501.18039047
42Antigen processing and presentation_Homo sapiens_hsa046121.17422469
43HTLV-I infection_Homo sapiens_hsa051661.14471435
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.10216908
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08989166
46Prostate cancer_Homo sapiens_hsa052151.08640727
47Chemokine signaling pathway_Homo sapiens_hsa040621.07417683
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07411026
49Viral myocarditis_Homo sapiens_hsa054161.07365577
50Measles_Homo sapiens_hsa051621.06724716
51Thyroid cancer_Homo sapiens_hsa052161.06663662
52Inositol phosphate metabolism_Homo sapiens_hsa005621.05190435
53Proteoglycans in cancer_Homo sapiens_hsa052051.03072032
54B cell receptor signaling pathway_Homo sapiens_hsa046621.02448441
55Colorectal cancer_Homo sapiens_hsa052101.02190954
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01430451
57Selenocompound metabolism_Homo sapiens_hsa004501.00685005
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98921605
59Acute myeloid leukemia_Homo sapiens_hsa052210.98877312
60Malaria_Homo sapiens_hsa051440.97525186
61Basal transcription factors_Homo sapiens_hsa030220.96134424
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96072254
63Hedgehog signaling pathway_Homo sapiens_hsa043400.95305915
64Insulin signaling pathway_Homo sapiens_hsa049100.94728821
65Legionellosis_Homo sapiens_hsa051340.94266462
66* Choline metabolism in cancer_Homo sapiens_hsa052310.93893034
67Focal adhesion_Homo sapiens_hsa045100.92507449
68Amoebiasis_Homo sapiens_hsa051460.92112612
69Hepatitis B_Homo sapiens_hsa051610.92102033
70Endometrial cancer_Homo sapiens_hsa052130.90997067
71Other glycan degradation_Homo sapiens_hsa005110.90738974
72GnRH signaling pathway_Homo sapiens_hsa049120.87041462
73ECM-receptor interaction_Homo sapiens_hsa045120.84780483
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.84429429
75Pancreatic cancer_Homo sapiens_hsa052120.83236414
76Pathways in cancer_Homo sapiens_hsa052000.83235035
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.82823349
78Epstein-Barr virus infection_Homo sapiens_hsa051690.82016016
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.81258013
80Bladder cancer_Homo sapiens_hsa052190.80698909
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.80003761
82Apoptosis_Homo sapiens_hsa042100.79743479
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78689245
84Wnt signaling pathway_Homo sapiens_hsa043100.76580366
85Hematopoietic cell lineage_Homo sapiens_hsa046400.75762663
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.75638224
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72470305
88Toxoplasmosis_Homo sapiens_hsa051450.71945184
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71325783
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70657680
91Leishmaniasis_Homo sapiens_hsa051400.69708564
92Shigellosis_Homo sapiens_hsa051310.69406283
93* Estrogen signaling pathway_Homo sapiens_hsa049150.67588596
94Dorso-ventral axis formation_Homo sapiens_hsa043200.67237402
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67191773
96Influenza A_Homo sapiens_hsa051640.65339059
97Tight junction_Homo sapiens_hsa045300.63822790
98FoxO signaling pathway_Homo sapiens_hsa040680.63079545
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62011097
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60776493
101Non-small cell lung cancer_Homo sapiens_hsa052230.60586127
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60467573
103T cell receptor signaling pathway_Homo sapiens_hsa046600.59641656
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.59583301
105Endocytosis_Homo sapiens_hsa041440.59444556
106Ribosome_Homo sapiens_hsa030100.57847047
107Graft-versus-host disease_Homo sapiens_hsa053320.57213737
108Osteoclast differentiation_Homo sapiens_hsa043800.56684294
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55097502
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54975806
111Allograft rejection_Homo sapiens_hsa053300.54954138
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54476529
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.54453160
114Type II diabetes mellitus_Homo sapiens_hsa049300.54144928
115Autoimmune thyroid disease_Homo sapiens_hsa053200.53415473
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52724240
117African trypanosomiasis_Homo sapiens_hsa051430.52413190
118Platelet activation_Homo sapiens_hsa046110.51231074
119Long-term potentiation_Homo sapiens_hsa047200.51172707
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50410102
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50362432
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49637992
123Rap1 signaling pathway_Homo sapiens_hsa040150.48854302
124HIF-1 signaling pathway_Homo sapiens_hsa040660.48554962
125TNF signaling pathway_Homo sapiens_hsa046680.47627733
126Melanoma_Homo sapiens_hsa052180.46939220
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45169122
128Prolactin signaling pathway_Homo sapiens_hsa049170.44304615
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41403914
130Hepatitis C_Homo sapiens_hsa051600.39834885
131RNA polymerase_Homo sapiens_hsa030200.39490518
132AMPK signaling pathway_Homo sapiens_hsa041520.38702864
133Insulin resistance_Homo sapiens_hsa049310.37204450
134VEGF signaling pathway_Homo sapiens_hsa043700.37053602
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37042041

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