SOX18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)8.34418365
2vascular endothelial growth factor signaling pathway (GO:0038084)7.23606167
3cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.84748141
4endothelium development (GO:0003158)5.61647755
5angiogenesis involved in wound healing (GO:0060055)5.32935348
6surfactant homeostasis (GO:0043129)5.30741385
7heart trabecula formation (GO:0060347)5.08911145
8cardiac myofibril assembly (GO:0055003)4.80804222
9positive regulation of vasculogenesis (GO:2001214)4.78401371
10endothelial tube morphogenesis (GO:0061154)4.72156396
11morphogenesis of an endothelium (GO:0003159)4.72156396
12vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.59000994
13blood vessel maturation (GO:0001955)4.55735741
14retina vasculature morphogenesis in camera-type eye (GO:0061299)4.51673388
15* lymphangiogenesis (GO:0001946)4.47351465
16sarcomere organization (GO:0045214)4.46588142
17Notch signaling involved in heart development (GO:0061314)4.42772007
18regulation of vasculogenesis (GO:2001212)4.31908049
19chemical homeostasis within a tissue (GO:0048875)4.22787724
20bundle of His cell to Purkinje myocyte communication (GO:0086069)4.21724478
21regulation of endothelial cell differentiation (GO:0045601)4.19246732
22transcytosis (GO:0045056)4.16223632
23basement membrane organization (GO:0071711)4.14117700
24plasma membrane repair (GO:0001778)4.11691603
25myofibril assembly (GO:0030239)4.08036605
26regulation of blood vessel endothelial cell migration (GO:0043535)4.01002289
27cell migration involved in sprouting angiogenesis (GO:0002042)3.84309219
28venous blood vessel morphogenesis (GO:0048845)3.74768428
29patterning of blood vessels (GO:0001569)3.71320822
30sprouting angiogenesis (GO:0002040)3.69259975
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.69127083
32ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.65161318
33* embryonic heart tube development (GO:0035050)3.60943171
34trabecula formation (GO:0060343)3.57108129
35peptidyl-tyrosine autophosphorylation (GO:0038083)3.52252983
36regulation of cardioblast differentiation (GO:0051890)3.52091761
37positive regulation of protein kinase C signaling (GO:0090037)3.42340934
38negative regulation of epithelial cell migration (GO:0010633)3.38226341
39cardiac muscle tissue morphogenesis (GO:0055008)3.37536821
40negative regulation of potassium ion transmembrane transport (GO:1901380)3.36797356
41regulation of actin filament-based movement (GO:1903115)3.36502933
42endothelial cell morphogenesis (GO:0001886)3.31227942
43* endothelial cell differentiation (GO:0045446)3.29827564
44negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.27260577
45cardiac muscle cell development (GO:0055013)3.22017041
46actin-myosin filament sliding (GO:0033275)3.20045958
47muscle filament sliding (GO:0030049)3.20045958
48* vasculogenesis (GO:0001570)3.19934780
49cell migration involved in heart development (GO:0060973)3.19287182
50regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.18936744
51wound healing, spreading of epidermal cells (GO:0035313)3.15756152
52negative regulation of blood vessel endothelial cell migration (GO:0043537)3.15675586
53endothelial cell proliferation (GO:0001935)3.15426236
54cardiac muscle contraction (GO:0060048)3.15368671
55positive regulation of glomerulus development (GO:0090193)3.14892730
56negative regulation of nitric-oxide synthase activity (GO:0051001)3.14382802
57fatty acid transmembrane transport (GO:1902001)3.12953226
58carnitine shuttle (GO:0006853)3.11796207
59low-density lipoprotein particle clearance (GO:0034383)3.11120831
60actomyosin structure organization (GO:0031032)3.10542727
61cardiac cell development (GO:0055006)3.09888894
62positive regulation of odontogenesis (GO:0042482)3.08180102
63glomerular filtration (GO:0003094)3.08167796
64muscle tissue morphogenesis (GO:0060415)3.08065002
65nephron epithelium development (GO:0072009)3.06933860
66ventricular cardiac muscle cell action potential (GO:0086005)3.06793093
67regulation of glomerular filtration (GO:0003093)3.05449911
68negative regulation of adherens junction organization (GO:1903392)3.05361158
69negative regulation of focal adhesion assembly (GO:0051895)3.05361158
70negative regulation of cell junction assembly (GO:1901889)3.05361158
71regulation of endothelial cell migration (GO:0010594)3.05156075
72* blood vessel endothelial cell migration (GO:0043534)3.03807028
73negative regulation of angiogenesis (GO:0016525)3.02498525
74positive regulation of endothelial cell differentiation (GO:0045603)3.01662262
75regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.00637828
76regulation of vascular permeability (GO:0043114)2.99432029
77renal filtration (GO:0097205)2.98990788
78negative regulation of actin filament bundle assembly (GO:0032232)2.98518712
79coronary vasculature morphogenesis (GO:0060977)2.97387266
80ventricular trabecula myocardium morphogenesis (GO:0003222)2.96413188
81regulation of sarcomere organization (GO:0060297)2.94956588
82regulation of sequestering of triglyceride (GO:0010889)2.92486396
83cardiac muscle cell proliferation (GO:0060038)2.91363721
84apoptotic process involved in morphogenesis (GO:0060561)2.90591548
85cardiac muscle hypertrophy (GO:0003300)2.90184471
86negative regulation of blood vessel morphogenesis (GO:2000181)2.88729130
87negative regulation of endothelial cell migration (GO:0010596)2.87722823
88adult heart development (GO:0007512)2.87621833
89negative regulation of endothelial cell apoptotic process (GO:2000352)2.87337097
90positive regulation of urine volume (GO:0035810)2.84731579
91regulation of synapse maturation (GO:0090128)2.84681866
92negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.84308013
93positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.83511545
94cAMP biosynthetic process (GO:0006171)2.83226871
95heart valve formation (GO:0003188)2.82538830
96labyrinthine layer development (GO:0060711)2.82097120
97adherens junction assembly (GO:0034333)2.81985537
98ovulation from ovarian follicle (GO:0001542)2.80464182
99negative regulation of vasculature development (GO:1901343)2.79853135
100regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79342389
101tricarboxylic acid cycle (GO:0006099)2.79038933
102aorta morphogenesis (GO:0035909)2.78338700
103regulation of skeletal muscle contraction (GO:0014819)2.78148805
104negative regulation of platelet activation (GO:0010544)2.77641059
105atrioventricular valve morphogenesis (GO:0003181)2.77501613
106potassium ion import (GO:0010107)2.77432905
107hyaluronan catabolic process (GO:0030214)2.77403000
108Notch receptor processing (GO:0007220)2.76970247
109semaphorin-plexin signaling pathway (GO:0071526)2.76156098
110negative regulation of DNA biosynthetic process (GO:2000279)2.75336941
111heart trabecula morphogenesis (GO:0061384)2.75289531
112regulation of p38MAPK cascade (GO:1900744)2.73996824
113cell volume homeostasis (GO:0006884)2.73659763
114regulation of the force of heart contraction (GO:0002026)2.72963932
115striated muscle hypertrophy (GO:0014897)2.72428428
116actin-mediated cell contraction (GO:0070252)2.70197204
117blood vessel morphogenesis (GO:0048514)2.69482066
118cell proliferation involved in metanephros development (GO:0072203)2.69150068
119positive regulation of endothelial cell proliferation (GO:0001938)2.69070194
120trabecula morphogenesis (GO:0061383)2.68821367
121regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.67704279
122regulation of urine volume (GO:0035809)2.65921238
123endothelial cell chemotaxis (GO:0035767)2.65591500
124* angiogenesis (GO:0001525)2.65341971
125negative regulation of vascular permeability (GO:0043116)2.65228190
126positive regulation of endothelial cell apoptotic process (GO:2000353)2.62905278
127negative regulation of erythrocyte differentiation (GO:0045647)2.62832167
128regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.62636417
129blood vessel remodeling (GO:0001974)2.61715439
130heart morphogenesis (GO:0003007)2.60812835
131negative regulation of Rho protein signal transduction (GO:0035024)2.59253421
132regulation of cardiac muscle cell contraction (GO:0086004)2.59016667
133axon extension involved in axon guidance (GO:0048846)2.57477750
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.57477750
135regulation of fatty acid oxidation (GO:0046320)2.57429956
136NADH metabolic process (GO:0006734)2.57097026
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.56097452
138positive regulation of blood vessel endothelial cell migration (GO:0043536)2.55885462
139positive regulation of cell junction assembly (GO:1901890)2.55741455
140positive regulation of focal adhesion assembly (GO:0051894)2.55741455
141glomerular basement membrane development (GO:0032836)2.55549265
142negative regulation of myoblast differentiation (GO:0045662)2.55441529
143gap junction assembly (GO:0016264)2.55068466
144positive regulation of endothelial cell migration (GO:0010595)2.53904383
145positive regulation of triglyceride lipase activity (GO:0061365)2.51493949
146positive regulation of lipoprotein lipase activity (GO:0051006)2.51493949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.25407426
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.72330830
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.98518112
4CLOCK_20551151_ChIP-Seq_293T_Human2.97708730
5GATA2_21666600_ChIP-Seq_HMVEC_Human2.89237342
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.88812353
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.82419411
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78163134
9ZNF263_19887448_ChIP-Seq_K562_Human2.66885513
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.46924445
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.42218720
12TBX20_22328084_ChIP-Seq_HEART_Mouse2.42218720
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.37946350
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22531335
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13344189
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.12021257
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.09911200
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09319177
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.00734164
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94904679
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.94101813
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88327301
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87151857
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.85224574
25* ESR2_21235772_ChIP-Seq_MCF-7_Human1.84160911
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71590219
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70721991
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69993128
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69269147
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69074784
31* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63838968
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.63464017
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.61970964
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55357605
35GATA1_19941826_ChIP-Seq_K562_Human1.54748126
36* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51195245
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50788595
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49366785
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45853109
40LXR_22292898_ChIP-Seq_THP-1_Human1.43240161
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42290514
42SMC3_22415368_ChIP-Seq_MEFs_Mouse1.41275685
43* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40101434
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39886999
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.38447505
46* EED_16625203_ChIP-ChIP_MESCs_Mouse1.38434630
47VDR_21846776_ChIP-Seq_THP-1_Human1.37128890
48* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35250575
49* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35250575
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34582464
51GATA1_22025678_ChIP-Seq_K562_Human1.34374702
52P68_20966046_ChIP-Seq_HELA_Human1.33730219
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33287999
54* TP53_20018659_ChIP-ChIP_R1E_Mouse1.33172146
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31556598
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31277265
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28950279
58* KDM2B_26808549_Chip-Seq_K562_Human1.27975203
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27844916
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24507523
61* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22551701
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.21957016
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21706165
64RACK7_27058665_Chip-Seq_MCF-7_Human1.20660660
65DROSHA_22980978_ChIP-Seq_HELA_Human1.18485913
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16810330
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16575216
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15929725
69* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15653427
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15398543
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14926321
72STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14790823
73* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12635656
74* KDM2B_26808549_Chip-Seq_DND41_Human1.12341757
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12162915
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.12101248
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12003863
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.11532345
79CJUN_26792858_Chip-Seq_BT549_Human1.11047858
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10405994
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.09942698
82* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09288856
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08958827
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08728424
85SMC4_20622854_ChIP-Seq_HELA_Human1.08586449
86* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07781102
87MYC_27129775_Chip-Seq_CORNEA_Mouse1.07543545
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06688652
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.06418363
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.06406742
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05520298
92RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04994306
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04912795
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04526456
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.04215656
96* RNF2_27304074_Chip-Seq_ESCs_Mouse1.03411385
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03130014
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01995857
99* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01937852
100* RING1B_27294783_Chip-Seq_NPCs_Mouse1.01735634
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01342743
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00649855
103* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99787726
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99580365
105* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98655445
106SOX2_20726797_ChIP-Seq_SW620_Human0.98509877
107TET1_21490601_ChIP-Seq_MESCs_Mouse0.98304986
108SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97436252
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96311993
110FOXA2_19822575_ChIP-Seq_HepG2_Human0.96228308
111* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95270886
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.95124403
113EZH2_27294783_Chip-Seq_ESCs_Mouse0.95041989
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94840707
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94574986
116CTCF_27219007_Chip-Seq_Bcells_Human0.94451928
117* EZH2_27304074_Chip-Seq_ESCs_Mouse0.92618126
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91790921
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91630056
120SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90646744
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.89744163
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.89598179
123AHR_22903824_ChIP-Seq_MCF-7_Human0.89404990
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88949237
125GATA2_19941826_ChIP-Seq_K562_Human0.86853284
126* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85918245
127TP63_22573176_ChIP-Seq_HFKS_Human0.85086152
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83881662
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81940341
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.81895563
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81725338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.81735852
2* MP0001879_abnormal_lymphatic_vessel4.71485481
3MP0004084_abnormal_cardiac_muscle4.02853876
4MP0004272_abnormal_basement_membrane3.89187383
5MP0002837_dystrophic_cardiac_calcinosis3.48694595
6MP0005167_abnormal_blood-brain_barrier3.43207377
7MP0006054_spinal_hemorrhage3.41922016
8MP0004215_abnormal_myocardial_fiber3.30786767
9MP0000751_myopathy3.10142249
10MP0003828_pulmonary_edema2.73777818
11MP0004036_abnormal_muscle_relaxation2.72809358
12MP0006138_congestive_heart_failure2.59873227
13MP0003724_increased_susceptibility_to2.59159447
14MP0005330_cardiomyopathy2.48434910
15MP0000013_abnormal_adipose_tissue2.38779933
16MP0001544_abnormal_cardiovascular_syste2.22607180
17MP0005385_cardiovascular_system_phenoty2.22607180
18MP0008775_abnormal_heart_ventricle2.18191161
19MP0003646_muscle_fatigue2.07635958
20MP0003279_aneurysm2.06359478
21MP0002972_abnormal_cardiac_muscle2.06335006
22MP0010630_abnormal_cardiac_muscle2.00666174
23MP0004130_abnormal_muscle_cell1.93860003
24MP0003705_abnormal_hypodermis_morpholog1.90886961
25MP0008438_abnormal_cutaneous_collagen1.83118690
26MP0000749_muscle_degeneration1.82644221
27MP0000767_abnormal_smooth_muscle1.82471128
28MP0004087_abnormal_muscle_fiber1.77471493
29MP0004085_abnormal_heartbeat1.72355631
30MP0005620_abnormal_muscle_contractility1.70678019
31MP0000750_abnormal_muscle_regeneration1.69324334
32MP0002127_abnormal_cardiovascular_syste1.68481378
33MP0004484_altered_response_of1.67855695
34MP0005670_abnormal_white_adipose1.67619452
35MP0001958_emphysema1.57568475
36MP0010030_abnormal_orbit_morphology1.52514766
37MP0005623_abnormal_meninges_morphology1.50488244
38MP0002332_abnormal_exercise_endurance1.46235738
39MP0003137_abnormal_impulse_conducting1.45367987
40MP0005165_increased_susceptibility_to1.44126043
41MP0003567_abnormal_fetal_cardiomyocyte1.39370828
42MP0002933_joint_inflammation1.38923360
43MP0002106_abnormal_muscle_physiology1.37218712
44MP0000343_altered_response_to1.33062381
45MP0004145_abnormal_muscle_electrophysio1.33059826
46* MP0002128_abnormal_blood_circulation1.32119274
47MP0008004_abnormal_stomach_pH1.26936340
48MP0002877_abnormal_melanocyte_morpholog1.26221984
49MP0005595_abnormal_vascular_smooth1.26095611
50MP0004147_increased_porphyrin_level1.24020173
51MP0000003_abnormal_adipose_tissue1.21992713
52MP0003300_gastrointestinal_ulcer1.21128674
53MP0002796_impaired_skin_barrier1.20846367
54MP0005666_abnormal_adipose_tissue1.20819482
55MP0003566_abnormal_cell_adhesion1.19797293
56MP0002925_abnormal_cardiovascular_devel1.19290309
57MP0000266_abnormal_heart_morphology1.19207290
58MP0005275_abnormal_skin_tensile1.18075480
59MP0005369_muscle_phenotype1.14797199
60MP0000678_abnormal_parathyroid_gland1.14752333
61MP0005375_adipose_tissue_phenotype1.14696698
62MP0002249_abnormal_larynx_morphology1.10683405
63MP0002295_abnormal_pulmonary_circulatio1.10160276
64MP0002138_abnormal_hepatobiliary_system1.09957239
65MP0002971_abnormal_brown_adipose1.05000917
66* MP0000249_abnormal_blood_vessel1.03929498
67* MP0001614_abnormal_blood_vessel1.02894035
68MP0000230_abnormal_systemic_arterial1.00442169
69MP0004858_abnormal_nervous_system1.00178950
70MP0004510_myositis0.99817196
71MP0003191_abnormal_cellular_cholesterol0.99601732
72MP0000759_abnormal_skeletal_muscle0.97959963
73MP0004233_abnormal_muscle_weight0.96916002
74MP0005187_abnormal_penis_morphology0.96574226
75MP0004185_abnormal_adipocyte_glucose0.92930245
76MP0009840_abnormal_foam_cell0.91432053
77MP0001851_eye_inflammation0.88623787
78MP0002269_muscular_atrophy0.83319919
79MP0003221_abnormal_cardiomyocyte_apopto0.80175143
80MP0005501_abnormal_skin_physiology0.78660127
81* MP0001784_abnormal_fluid_regulation0.77511500
82MP0001915_intracranial_hemorrhage0.76677367
83MP0002108_abnormal_muscle_morphology0.76116109
84MP0009115_abnormal_fat_cell0.75431056
85MP0003011_delayed_dark_adaptation0.74140833
86MP0000049_abnormal_middle_ear0.73616020
87MP0003045_fibrosis0.73296562
88MP0010329_abnormal_lipoprotein_level0.72627850
89MP0003950_abnormal_plasma_membrane0.72321389
90MP0000747_muscle_weakness0.71633166
91MP0005360_urolithiasis0.70967151
92MP0001502_abnormal_circadian_rhythm0.68962495
93* MP0003948_abnormal_gas_homeostasis0.68239050
94MP0002932_abnormal_joint_morphology0.68136280
95MP0004883_abnormal_blood_vessel0.67875200
96MP0000467_abnormal_esophagus_morphology0.65789591
97MP0001849_ear_inflammation0.65781139
98MP0003943_abnormal_hepatobiliary_system0.63921744
99MP0005164_abnormal_response_to0.63134814
100MP0004782_abnormal_surfactant_physiolog0.62778618
101MP0003091_abnormal_cell_migration0.62352598
102MP0003303_peritoneal_inflammation0.61075433
103MP0002133_abnormal_respiratory_system0.60087723
104MP0005388_respiratory_system_phenotype0.60087723
105MP0005085_abnormal_gallbladder_physiolo0.58867809
106MP0001661_extended_life_span0.57897250
107MP0009278_abnormal_bone_marrow0.57828564
108MP0005451_abnormal_body_composition0.57584166
109MP0005023_abnormal_wound_healing0.57161848
110MP0000733_abnormal_muscle_development0.56613872
111MP0003385_abnormal_body_wall0.56454254
112MP0002088_abnormal_embryonic_growth/wei0.53605879
113MP0005319_abnormal_enzyme/_coenzyme0.53455583
114MP0003252_abnormal_bile_duct0.53407537
115MP0002896_abnormal_bone_mineralization0.51621885
116MP0005508_abnormal_skeleton_morphology0.50902938
117MP0005083_abnormal_biliary_tract0.50790951
118MP0003984_embryonic_growth_retardation0.50572591
119MP0000465_gastrointestinal_hemorrhage0.50408679
120MP0002970_abnormal_white_adipose0.50218502
121MP0005503_abnormal_tendon_morphology0.50097473
122MP0005334_abnormal_fat_pad0.49935063
123MP0005084_abnormal_gallbladder_morpholo0.48968688
124MP0003959_abnormal_lean_body0.48766518
125MP0009053_abnormal_anal_canal0.47986667
126MP0003935_abnormal_craniofacial_develop0.47527830
127MP0003075_altered_response_to0.47266015
128MP0009384_cardiac_valve_regurgitation0.46836514
129MP0008875_abnormal_xenobiotic_pharmacok0.46558753
130MP0009643_abnormal_urine_homeostasis0.46547239

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.68043980
2Ventricular tachycardia (HP:0004756)5.66390612
3Muscle fiber splitting (HP:0003555)5.03036709
4Polycythemia (HP:0001901)4.91422542
5Increased connective tissue (HP:0009025)4.62256278
6Atrial fibrillation (HP:0005110)4.57870495
7Broad metatarsal (HP:0001783)4.33410440
8Primary atrial arrhythmia (HP:0001692)4.25959155
9Supraventricular arrhythmia (HP:0005115)4.24068853
10Supraventricular tachycardia (HP:0004755)4.07420301
11Right ventricular cardiomyopathy (HP:0011663)3.95661121
12Lipoatrophy (HP:0100578)3.90550877
13Hyporeflexia of lower limbs (HP:0002600)3.85707656
14Exercise-induced muscle cramps (HP:0003710)3.75369963
15Hematochezia (HP:0002573)3.60267520
16Spontaneous hematomas (HP:0007420)3.60093924
17Cerebral aneurysm (HP:0004944)3.52414802
18Calf muscle hypertrophy (HP:0008981)3.50988462
19Exercise-induced myalgia (HP:0003738)3.32285438
20Esophageal varix (HP:0002040)3.31328574
21Subaortic stenosis (HP:0001682)3.26135083
22Abnormality of the left ventricular outflow tract (HP:0011103)3.26135083
23Syncope (HP:0001279)3.25145676
24Increased variability in muscle fiber diameter (HP:0003557)3.23329888
25Atrioventricular block (HP:0001678)3.16708370
26Muscle hypertrophy of the lower extremities (HP:0008968)3.14975317
27Difficulty running (HP:0009046)3.14565146
28Abnormality of the calf musculature (HP:0001430)3.13756972
29Dilated cardiomyopathy (HP:0001644)3.11921676
30Cerebral hemorrhage (HP:0001342)3.09784186
31Abnormality of skeletal muscle fiber size (HP:0012084)2.92602035
32Asymmetric septal hypertrophy (HP:0001670)2.92191026
33Wrist flexion contracture (HP:0001239)2.91694539
34Pulmonary artery stenosis (HP:0004415)2.90012029
35Myotonia (HP:0002486)2.89392459
36Prolonged QT interval (HP:0001657)2.89054608
37Deep venous thrombosis (HP:0002625)2.88390380
38Hypoglycemic coma (HP:0001325)2.85311138
39EMG: myopathic abnormalities (HP:0003458)2.84396162
40Myoglobinuria (HP:0002913)2.84351644
41Bundle branch block (HP:0011710)2.82628562
42Heart block (HP:0012722)2.82079246
43Protrusio acetabuli (HP:0003179)2.80284358
44Palpitations (HP:0001962)2.76697194
45Abnormal atrioventricular conduction (HP:0005150)2.73031068
46Visceral angiomatosis (HP:0100761)2.72675741
47Joint hemorrhage (HP:0005261)2.70279927
48Abnormality of the nasal mucosa (HP:0000433)2.65749143
49Bulbar palsy (HP:0001283)2.64791475
50Type 1 muscle fiber predominance (HP:0003803)2.64003122
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.63516330
52Premature rupture of membranes (HP:0001788)2.57996847
53Difficulty climbing stairs (HP:0003551)2.56307260
54Hemangiomatosis (HP:0007461)2.54455954
55Mesangial abnormality (HP:0001966)2.54208648
56Abnormality of the hepatic vasculature (HP:0006707)2.52195530
57Distal lower limb amyotrophy (HP:0008944)2.50726195
58Spinal rigidity (HP:0003306)2.49725017
59Acanthosis nigricans (HP:0000956)2.47886024
60Ventricular arrhythmia (HP:0004308)2.44729245
61Aneurysm (HP:0002617)2.41936105
62Muscle fiber inclusion bodies (HP:0100299)2.41355271
63Ventricular fibrillation (HP:0001663)2.40043359
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.38954134
65Neonatal death (HP:0003811)2.38295943
66Short 4th metacarpal (HP:0010044)2.37987037
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37987037
68Stroke (HP:0001297)2.37945843
69Short hallux (HP:0010109)2.37724361
70Round ear (HP:0100830)2.35952185
71Mildly elevated creatine phosphokinase (HP:0008180)2.35768961
72Cavernous hemangioma (HP:0001048)2.33807258
73* Nonimmune hydrops fetalis (HP:0001790)2.33296811
74Obstructive sleep apnea (HP:0002870)2.32932817
75Hypoplastic ischia (HP:0003175)2.31275809
76Abnormality of the 4th metacarpal (HP:0010012)2.31011003
77Nemaline bodies (HP:0003798)2.29499331
78Congenital, generalized hypertrichosis (HP:0004540)2.28108605
79Delayed CNS myelination (HP:0002188)2.27065758
80Aortic dissection (HP:0002647)2.26415110
81Areflexia of lower limbs (HP:0002522)2.25026812
82Polygenic inheritance (HP:0010982)2.23927322
83Ankle contracture (HP:0006466)2.21540310
84Aplasia/Hypoplasia of the hallux (HP:0008362)2.19168314
85Large for gestational age (HP:0001520)2.18879292
86Complement deficiency (HP:0004431)2.14747441
87Hyperinsulinemic hypoglycemia (HP:0000825)2.12443772
88Hip contracture (HP:0003273)2.11543039
89Ketoacidosis (HP:0001993)2.11505150
90Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09974914
91Hydroureter (HP:0000072)2.09497193
92Abnormality of complement system (HP:0005339)2.09288869
93Systemic lupus erythematosus (HP:0002725)2.09207784
94Abnormality of the ischium (HP:0003174)2.08936984
95Conjunctival telangiectasia (HP:0000524)2.07581314
96Rhabdomyolysis (HP:0003201)2.07574083
97Pigmentary retinal degeneration (HP:0001146)2.07118593
98Neck muscle weakness (HP:0000467)2.04801190
99Bladder diverticulum (HP:0000015)2.03981282
100Shallow orbits (HP:0000586)2.02787233
101Adactyly (HP:0009776)2.00129657
102Distal lower limb muscle weakness (HP:0009053)1.99889168
103Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99389121
104Abnormality of the sella turcica (HP:0002679)1.98322453
105Fragile skin (HP:0001030)1.98287950
106Distal arthrogryposis (HP:0005684)1.96994159
107Muscle stiffness (HP:0003552)1.96736471
108Pancreatic islet-cell hyperplasia (HP:0004510)1.96287867
109Growth hormone excess (HP:0000845)1.95967541
110Skull defect (HP:0001362)1.95848515
111Testicular atrophy (HP:0000029)1.94915417
112Absent hand (HP:0004050)1.94160258
113Vascular tortuosity (HP:0004948)1.92937038
114Hypertriglyceridemia (HP:0002155)1.92170947
115Milia (HP:0001056)1.91879029
116Abnormal EKG (HP:0003115)1.91825798
117Abnormality of the anterior chamber (HP:0000593)1.91519948
118Capillary hemangiomas (HP:0005306)1.90942924
119Porencephaly (HP:0002132)1.89641111
120* Lymphangioma (HP:0100764)1.88311540
121Atrophic scars (HP:0001075)1.87281495
122Hypoplasia of the iris (HP:0007676)1.83631488
123Facial diplegia (HP:0001349)1.83255793
124* Venous abnormality (HP:0002624)1.83217992
125Hemorrhage of the eye (HP:0011885)1.82562876
126Pulmonary hypertension (HP:0002092)1.81588728
127Ectopia lentis (HP:0001083)1.81191590
128Aortic aneurysm (HP:0004942)1.81168595
129Aortic valve stenosis (HP:0001650)1.81156885
130Congestive heart failure (HP:0001635)1.81020408
131Abnormality of fatty-acid metabolism (HP:0004359)1.80390559
132Reduced subcutaneous adipose tissue (HP:0003758)1.80214139
133Portal hypertension (HP:0001409)1.79472817
134Limb-girdle muscle atrophy (HP:0003797)1.79251066
135Axonal loss (HP:0003447)1.79222275
136* Venous insufficiency (HP:0005293)1.78685611
137Myopathic facies (HP:0002058)1.78660335
138Abnormality of the tricuspid valve (HP:0001702)1.78641177
139Neoplasm of the heart (HP:0100544)1.78300981
140Ulnar deviation of the wrist (HP:0003049)1.77065268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.65370315
2KDR8.12089719
3TGFBR23.61932843
4TTN2.53645655
5TGFBR12.31478075
6MYLK2.22945000
7EPHB22.02328764
8RIPK11.99887893
9TRIB31.89308165
10PKN21.79527098
11FES1.76843664
12ERN11.68675713
13DMPK1.59420364
14LMTK21.54996535
15PTK2B1.52385593
16GRK11.49021844
17PDK21.48011823
18TSSK61.45132262
19PHKG11.37838860
20PHKG21.37838860
21BCKDK1.32977734
22EPHB11.24253179
23PTK61.22727185
24FER1.17647039
25EEF2K1.08153710
26PRKD11.06395910
27PDGFRA1.04107495
28MAPK121.01427636
29PRPF4B0.96608177
30MAP3K60.96209368
31PDK40.94406317
32PDK30.94406317
33FGFR40.93816053
34TESK10.93776876
35INSRR0.91786616
36WNK40.91614049
37NTRK10.90612520
38MAP2K30.84023167
39CAMK40.82010137
40OBSCN0.81594588
41SIK10.79454996
42PIK3CA0.77662745
43PAK40.73832733
44MAP4K10.71105343
45PRKCH0.66205148
46TRPM70.65013893
47IRAK30.64548932
48PRKAA20.64465016
49PRKG20.64029528
50SMG10.63704938
51MAPK40.63126424
52CAMK1D0.62252805
53MAPK150.58127890
54EPHA20.57993487
55JAK10.57427610
56DDR20.56789998
57ARAF0.55995072
58MAP3K70.55225620
59LRRK20.54694385
60CAMK1G0.53989745
61MAP3K110.53177187
62ABL20.52925746
63MUSK0.52019681
64ZAP700.51834382
65MAP3K10.51478491
66RPS6KA20.51146410
67MAP3K100.50514519
68ILK0.50507223
69MAP3K30.49935933
70PRKD30.48659080
71PRKD20.48602070
72PAK30.47868809
73PTK20.47671263
74ROCK10.46732790
75AKT20.45161366
76FGFR20.44137591
77MAP2K10.43367372
78RPS6KL10.43240879
79RPS6KC10.43240879
80RET0.42836242
81JAK20.42108355
82MAPK70.41893580
83LATS10.39842799
84MOS0.39366123
85CSK0.39316828
86GRK70.39140801
87MAP2K20.38973186
88PDPK10.38417508
89LIMK10.38382958
90MET0.36460518
91ITK0.35880342
92TYRO30.35159092
93BMX0.34686169
94CDK90.34683196
95BLK0.34127705
96PRKAA10.34068141
97PRKCE0.33493607
98PINK10.32906680
99MAPKAPK30.32660249
100DAPK20.32418039
101CAMK10.31305657
102EPHA30.31216489
103FLT30.31056769
104NEK90.30747403
105MAP3K130.30710294
106PDGFRB0.30633273
107ICK0.30407479
108GSK3A0.30317380
109STK240.29857691
110SRC0.29513261
111AKT30.28620131
112IGF1R0.28378102
113DAPK30.27482645
114PAK20.26527221
115LATS20.26482310
116HIPK20.25827064
117CDK120.25784845
118GRK50.24934506
119STK390.24290767
120CDC42BPA0.24143908
121FGFR30.23936337
122EGFR0.22964089
123JAK30.22116186
124MTOR0.22005560
125MARK20.20976390
126TBK10.20563618
127ROCK20.20074156
128PKN10.19604545
129TEC0.19578175
130PRKACB0.17654257
131CAMK2D0.16042194
132RPS6KA60.13960676

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.37988213
2Dilated cardiomyopathy_Homo sapiens_hsa054142.89089472
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.63957474
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.62348381
5Prion diseases_Homo sapiens_hsa050202.59558241
6Fatty acid degradation_Homo sapiens_hsa000712.56272397
7Propanoate metabolism_Homo sapiens_hsa006402.35264174
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28077731
9ECM-receptor interaction_Homo sapiens_hsa045122.18732566
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.09840262
11Cardiac muscle contraction_Homo sapiens_hsa042602.09511744
12Sulfur relay system_Homo sapiens_hsa041221.98072835
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97124798
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94419678
15Focal adhesion_Homo sapiens_hsa045101.93753778
16PPAR signaling pathway_Homo sapiens_hsa033201.93450041
17Fatty acid metabolism_Homo sapiens_hsa012121.79079805
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.59673880
19Adherens junction_Homo sapiens_hsa045201.55720144
20Complement and coagulation cascades_Homo sapiens_hsa046101.47031187
21Arginine biosynthesis_Homo sapiens_hsa002201.45394881
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41605698
23Bile secretion_Homo sapiens_hsa049761.37195129
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.36963879
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35853383
26Tryptophan metabolism_Homo sapiens_hsa003801.29931977
27Viral myocarditis_Homo sapiens_hsa054161.29154615
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28768281
29Protein digestion and absorption_Homo sapiens_hsa049741.28116355
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22994573
31Insulin resistance_Homo sapiens_hsa049311.22417748
32Notch signaling pathway_Homo sapiens_hsa043301.21911314
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20562542
34Carbon metabolism_Homo sapiens_hsa012001.16913774
35Rap1 signaling pathway_Homo sapiens_hsa040151.16815436
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.16034259
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09120528
38Amoebiasis_Homo sapiens_hsa051461.06499186
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06070292
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.02731955
41Butanoate metabolism_Homo sapiens_hsa006501.02726271
42Tight junction_Homo sapiens_hsa045300.97743768
43Dorso-ventral axis formation_Homo sapiens_hsa043200.97703071
44GnRH signaling pathway_Homo sapiens_hsa049120.97345943
45Nitrogen metabolism_Homo sapiens_hsa009100.97255042
46Basal cell carcinoma_Homo sapiens_hsa052170.96843240
47Renin secretion_Homo sapiens_hsa049240.95949256
48Pyruvate metabolism_Homo sapiens_hsa006200.94389327
49Histidine metabolism_Homo sapiens_hsa003400.92630667
50Malaria_Homo sapiens_hsa051440.92576752
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92222268
52Proteoglycans in cancer_Homo sapiens_hsa052050.91631521
53Platelet activation_Homo sapiens_hsa046110.90153150
54Parkinsons disease_Homo sapiens_hsa050120.90117522
55Tyrosine metabolism_Homo sapiens_hsa003500.89254748
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88528499
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87261443
58HIF-1 signaling pathway_Homo sapiens_hsa040660.84813478
59Small cell lung cancer_Homo sapiens_hsa052220.83315427
60Ovarian steroidogenesis_Homo sapiens_hsa049130.83260443
61Glycerolipid metabolism_Homo sapiens_hsa005610.80877679
62Lysine degradation_Homo sapiens_hsa003100.80830007
63Fatty acid elongation_Homo sapiens_hsa000620.80271352
64Caffeine metabolism_Homo sapiens_hsa002320.80110146
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79396932
66Renal cell carcinoma_Homo sapiens_hsa052110.78283083
67VEGF signaling pathway_Homo sapiens_hsa043700.78159232
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77941053
69ABC transporters_Homo sapiens_hsa020100.77114748
70Pertussis_Homo sapiens_hsa051330.76586049
71beta-Alanine metabolism_Homo sapiens_hsa004100.75549227
72Alzheimers disease_Homo sapiens_hsa050100.73140265
73African trypanosomiasis_Homo sapiens_hsa051430.73081639
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.70477944
75Other glycan degradation_Homo sapiens_hsa005110.69791651
76Axon guidance_Homo sapiens_hsa043600.67940847
77cAMP signaling pathway_Homo sapiens_hsa040240.66937145
78MAPK signaling pathway_Homo sapiens_hsa040100.66554693
79Renin-angiotensin system_Homo sapiens_hsa046140.66065387
80Gap junction_Homo sapiens_hsa045400.65994520
81AMPK signaling pathway_Homo sapiens_hsa041520.65413899
82Pathways in cancer_Homo sapiens_hsa052000.64686399
83Glucagon signaling pathway_Homo sapiens_hsa049220.64414612
84Oxidative phosphorylation_Homo sapiens_hsa001900.63168663
85Bladder cancer_Homo sapiens_hsa052190.63135888
86Fat digestion and absorption_Homo sapiens_hsa049750.62647553
87Hedgehog signaling pathway_Homo sapiens_hsa043400.62537514
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61540992
89Gastric acid secretion_Homo sapiens_hsa049710.60901653
90Toxoplasmosis_Homo sapiens_hsa051450.60018696
91Melanogenesis_Homo sapiens_hsa049160.59986351
92Glioma_Homo sapiens_hsa052140.59874057
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59280336
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58434332
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58314689
96Ras signaling pathway_Homo sapiens_hsa040140.58013642
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57986156
98Choline metabolism in cancer_Homo sapiens_hsa052310.57596605
99Peroxisome_Homo sapiens_hsa041460.56721318
100Oxytocin signaling pathway_Homo sapiens_hsa049210.54296951
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54280473
102Insulin signaling pathway_Homo sapiens_hsa049100.53438299
103Starch and sucrose metabolism_Homo sapiens_hsa005000.51106647
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.50459859
105Circadian rhythm_Homo sapiens_hsa047100.48426270
106Arginine and proline metabolism_Homo sapiens_hsa003300.47140915
107Chronic myeloid leukemia_Homo sapiens_hsa052200.46439774
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46146641
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46009157
110Acute myeloid leukemia_Homo sapiens_hsa052210.45270062
111Estrogen signaling pathway_Homo sapiens_hsa049150.45152402
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.45001870
113Galactose metabolism_Homo sapiens_hsa000520.44943997
114Phenylalanine metabolism_Homo sapiens_hsa003600.44408196
115Staphylococcus aureus infection_Homo sapiens_hsa051500.43774826
116Pancreatic secretion_Homo sapiens_hsa049720.42531435
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42264605
118TNF signaling pathway_Homo sapiens_hsa046680.41939222
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41559094
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.41273564
121TGF-beta signaling pathway_Homo sapiens_hsa043500.41202079
122Calcium signaling pathway_Homo sapiens_hsa040200.40330975
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40242713
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38694879
125Thyroid hormone synthesis_Homo sapiens_hsa049180.37996260
126Fatty acid biosynthesis_Homo sapiens_hsa000610.37450984
127Huntingtons disease_Homo sapiens_hsa050160.36416807
128Fructose and mannose metabolism_Homo sapiens_hsa000510.36280898
129Vitamin digestion and absorption_Homo sapiens_hsa049770.34504629
130Hippo signaling pathway_Homo sapiens_hsa043900.32982018
131Endocytosis_Homo sapiens_hsa041440.31669956

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