SOX11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebral cortex radially oriented cell migration (GO:0021799)7.27229675
2pyrimidine nucleobase catabolic process (GO:0006208)7.01854334
3central nervous system projection neuron axonogenesis (GO:0021952)5.41611694
4nucleobase catabolic process (GO:0046113)5.12697226
5ganglion development (GO:0061548)4.98321153
6cerebral cortex cell migration (GO:0021795)4.74152370
7olfactory bulb development (GO:0021772)4.58526829
8microtubule depolymerization (GO:0007019)4.57797286
9negative regulation of axon extension involved in axon guidance (GO:0048843)4.37677232
10facial nerve structural organization (GO:0021612)4.36993186
11axonal fasciculation (GO:0007413)4.34802689
12protein-DNA complex disassembly (GO:0032986)4.31505646
13nucleosome disassembly (GO:0006337)4.31505646
14* limb bud formation (GO:0060174)4.31350510
15cell proliferation in forebrain (GO:0021846)4.26136986
16sequestering of actin monomers (GO:0042989)4.24985065
17central nervous system neuron axonogenesis (GO:0021955)4.11971066
18negative regulation of axon guidance (GO:1902668)4.10966259
19hindbrain development (GO:0030902)4.09445870
20establishment of mitochondrion localization (GO:0051654)4.03648842
21negative regulation of stem cell proliferation (GO:2000647)4.03425559
22behavioral response to nicotine (GO:0035095)3.94524583
23retinal ganglion cell axon guidance (GO:0031290)3.94431966
24regulation of NFAT protein import into nucleus (GO:0051532)3.88881466
25neuron recognition (GO:0008038)3.87624957
26cellular response to prostaglandin stimulus (GO:0071379)3.84758610
27* neural tube formation (GO:0001841)3.76838169
28regulation of development, heterochronic (GO:0040034)3.70896373
29hippocampus development (GO:0021766)3.67710963
30* spinal cord development (GO:0021510)3.67547500
31cranial nerve morphogenesis (GO:0021602)3.67458966
32cell migration in hindbrain (GO:0021535)3.66199238
33head development (GO:0060322)3.65310040
34* sympathetic nervous system development (GO:0048485)3.60698081
35neuron cell-cell adhesion (GO:0007158)3.58871637
36regulation of timing of cell differentiation (GO:0048505)3.57957590
37kidney morphogenesis (GO:0060993)3.57762152
38centriole replication (GO:0007099)3.56821423
39microtubule polymerization or depolymerization (GO:0031109)3.56710821
40proximal/distal pattern formation (GO:0009954)3.49653252
41regulation of collateral sprouting (GO:0048670)3.44767410
42axon extension (GO:0048675)3.43356769
43histone H3-K4 trimethylation (GO:0080182)3.43088880
44regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.42612727
45DNA double-strand break processing (GO:0000729)3.39886674
46dentate gyrus development (GO:0021542)3.39526456
47vocalization behavior (GO:0071625)3.38744071
48mRNA splice site selection (GO:0006376)3.36461150
49lung secretory cell differentiation (GO:0061140)3.30382409
50telencephalon cell migration (GO:0022029)3.29770002
51cranial nerve structural organization (GO:0021604)3.28962647
52synapse assembly (GO:0007416)3.26604362
53nonmotile primary cilium assembly (GO:0035058)3.26517764
54histone H2A acetylation (GO:0043968)3.26211717
55regulation of mRNA splicing, via spliceosome (GO:0048024)3.25936281
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24974085
57forebrain neuron differentiation (GO:0021879)3.24119878
58adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.21827369
59regulation of centriole replication (GO:0046599)3.20388556
60neuronal stem cell maintenance (GO:0097150)3.20170032
61positive regulation of neuroblast proliferation (GO:0002052)3.18948260
62forebrain cell migration (GO:0021885)3.18858239
63regulation of chromatin binding (GO:0035561)3.18837848
64substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.18450309
65substrate-independent telencephalic tangential migration (GO:0021826)3.18450309
66regulation of gene expression by genetic imprinting (GO:0006349)3.16721944
67protein localization to microtubule (GO:0035372)3.15853778
68neuron projection extension involved in neuron projection guidance (GO:1902284)3.15299933
69axon extension involved in axon guidance (GO:0048846)3.15299933
70transmission of nerve impulse (GO:0019226)3.14140654
71behavioral response to ethanol (GO:0048149)3.13908155
72viral mRNA export from host cell nucleus (GO:0046784)3.13544303
73mitochondrion transport along microtubule (GO:0047497)3.13426687
74establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.13426687
75gamma-aminobutyric acid transport (GO:0015812)3.10794357
76centriole assembly (GO:0098534)3.09094677
77dendritic spine morphogenesis (GO:0060997)3.03007282
78cell differentiation involved in kidney development (GO:0061005)3.01112852
79neurotransmitter-gated ion channel clustering (GO:0072578)3.01072684
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99877603
81regulation of axon extension involved in axon guidance (GO:0048841)2.98950654
82regulation of axon guidance (GO:1902667)2.97987857
83positive regulation of neural precursor cell proliferation (GO:2000179)2.97837288
84regulation of telomere maintenance (GO:0032204)2.96009881
85peptidyl-arginine methylation (GO:0018216)2.94935904
86peptidyl-arginine N-methylation (GO:0035246)2.94935904
87dendrite morphogenesis (GO:0048813)2.94741122
88glycosphingolipid biosynthetic process (GO:0006688)2.94626752
89dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.93399473
90presynaptic membrane assembly (GO:0097105)2.88970962
91neuron projection extension (GO:1990138)2.88612573
92positive regulation of mitochondrial fission (GO:0090141)2.87928727
93histone H3-K9 methylation (GO:0051567)2.87388378
94protein localization to cilium (GO:0061512)2.85848076
95positive regulation of synapse assembly (GO:0051965)2.83852631
96regulation of G0 to G1 transition (GO:0070316)2.83065455
97DNA damage response, detection of DNA damage (GO:0042769)2.82681796
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81966531
99negative regulation of translation, ncRNA-mediated (GO:0040033)2.81966531
100regulation of translation, ncRNA-mediated (GO:0045974)2.81966531
101neuron fate determination (GO:0048664)2.81894236
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.81813685
103peptidyl-lysine trimethylation (GO:0018023)2.80097267
104negative regulation of microtubule polymerization (GO:0031115)2.80060158
105protein polyglutamylation (GO:0018095)2.79454623
106protein localization to synapse (GO:0035418)2.78786168
107calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78473080
108epithelial cilium movement (GO:0003351)2.78357326
109negative regulation of glycogen biosynthetic process (GO:0045719)2.77161516
110positive regulation of cell cycle checkpoint (GO:1901978)2.76712536
111positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.74889968
112negative regulation of oligodendrocyte differentiation (GO:0048715)2.74791006
113neuron migration (GO:0001764)2.74031216
114intraciliary transport (GO:0042073)2.73930892
115cilium morphogenesis (GO:0060271)2.73179206
116negative regulation of dendrite development (GO:2000171)2.72270076
117presynaptic membrane organization (GO:0097090)2.67830690
118mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.67760406
119positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.67760406
120postsynaptic membrane organization (GO:0001941)2.67188651
121positive regulation of DNA-templated transcription, elongation (GO:0032786)2.66630951
122negative regulation of axon extension (GO:0030517)2.66373540
123DNA integration (GO:0015074)2.66092646
124regulation of glycogen (starch) synthase activity (GO:2000465)2.64836221
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64253038
126positive regulation of amino acid transport (GO:0051957)2.63863869
127dosage compensation (GO:0007549)2.63049310
128snRNA transcription (GO:0009301)2.61877933
129pyrimidine dimer repair (GO:0006290)2.60885268
130neuronal action potential propagation (GO:0019227)2.60432192
131regulation of dendritic spine morphogenesis (GO:0061001)2.60325981
132DNA demethylation (GO:0080111)2.60075602
133artery development (GO:0060840)2.58688458
134regulation of feeding behavior (GO:0060259)2.57679488
135ephrin receptor signaling pathway (GO:0048013)2.56937517
136adult walking behavior (GO:0007628)2.56878699
137negative chemotaxis (GO:0050919)2.56772840
138G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56754340
139auditory behavior (GO:0031223)2.56441903
140ionotropic glutamate receptor signaling pathway (GO:0035235)2.56050060
141cell differentiation involved in metanephros development (GO:0072202)2.56002469
142dendrite development (GO:0016358)2.56000914
143cilium assembly (GO:0042384)2.54731511
144synaptic transmission, cholinergic (GO:0007271)2.54625995
145axonogenesis (GO:0007409)2.54274282
146cilium organization (GO:0044782)2.54094355
147regulation of neuroblast proliferation (GO:1902692)2.54084959
148negative regulation of glycogen metabolic process (GO:0070874)2.53921617
149viral genome replication (GO:0019079)2.53004797
150mechanosensory behavior (GO:0007638)2.51740326
151regulation of synapse maturation (GO:0090128)2.51563921
152genetic imprinting (GO:0071514)2.51502212
153cell differentiation in spinal cord (GO:0021515)2.51331517
154inner ear receptor stereocilium organization (GO:0060122)2.49825435
155response to pheromone (GO:0019236)2.49159696
156positive regulation of oligodendrocyte differentiation (GO:0048714)2.49100283
157startle response (GO:0001964)2.47807288
158limb development (GO:0060173)2.47641867
159specification of organ identity (GO:0010092)2.47193241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.53143965
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.54476708
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.02422067
4CBX2_27304074_Chip-Seq_ESCs_Mouse2.91558247
5POU5F1_16153702_ChIP-ChIP_HESCs_Human2.80548313
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77039355
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.62269674
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59350303
9GBX2_23144817_ChIP-Seq_PC3_Human2.54103615
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.39679783
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28053133
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27723002
13IGF1R_20145208_ChIP-Seq_DFB_Human2.14019456
14* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.13428987
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.13264352
16EWS_26573619_Chip-Seq_HEK293_Human2.12618663
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08219305
18* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98351105
19* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98351105
20* RNF2_27304074_Chip-Seq_NSC_Mouse1.98034884
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95394613
22* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95029183
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93525232
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.93375065
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.92538264
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91978466
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90456205
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88516167
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.88358965
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87073114
31* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85355984
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.80544200
33SOX2_16153702_ChIP-ChIP_HESCs_Human1.73288297
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66893800
35SOX2_18555785_ChIP-Seq_MESCs_Mouse1.66768445
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66437176
37* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66270305
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63443016
39* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62996552
40* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61132245
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59755171
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59755171
43TAF15_26573619_Chip-Seq_HEK293_Human1.56223818
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.55199634
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54901175
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54046555
47REST_21632747_ChIP-Seq_MESCs_Mouse1.53392496
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51764318
49* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50496805
50* P300_19829295_ChIP-Seq_ESCs_Human1.47780218
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46281328
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44542718
53AHR_22903824_ChIP-Seq_MCF-7_Human1.44111676
54* AR_25329375_ChIP-Seq_VCAP_Human1.43235893
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43220281
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43021691
57CBP_20019798_ChIP-Seq_JUKART_Human1.43021691
58* SOX9_26525672_Chip-Seq_HEART_Mouse1.42080130
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39452582
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39201610
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37797771
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36223279
63* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32168316
64STAT3_23295773_ChIP-Seq_U87_Human1.30780051
65ZNF274_21170338_ChIP-Seq_K562_Hela1.30003773
66TP53_18474530_ChIP-ChIP_U2OS_Human1.29901948
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.29178916
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.28468734
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27790476
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.25160966
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24340738
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23814326
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22871503
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21967443
75* TCF4_23295773_ChIP-Seq_U87_Human1.21372047
76BCAT_22108803_ChIP-Seq_LS180_Human1.20514025
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20484779
78* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20318447
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20004237
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19459889
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18556347
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18366661
83* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18289840
84AR_21572438_ChIP-Seq_LNCaP_Human1.17903117
85* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17765715
86IRF1_19129219_ChIP-ChIP_H3396_Human1.15118357
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.14139392
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12534678
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12515113
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.12493668
91VDR_22108803_ChIP-Seq_LS180_Human1.11930368
92SMAD4_21799915_ChIP-Seq_A2780_Human1.11795338
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07916976
94MYC_18940864_ChIP-ChIP_HL60_Human1.07128459
95NANOG_16153702_ChIP-ChIP_HESCs_Human1.07015171
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.06802525
97FUS_26573619_Chip-Seq_HEK293_Human1.06254527
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.05820987
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05594457
100* RUNX2_22187159_ChIP-Seq_PCA_Human1.05315139
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05269997
102* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05004391
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04451406
104TCF4_22108803_ChIP-Seq_LS180_Human1.04394130
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04040615
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03799278
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03083437
108* FLI1_21867929_ChIP-Seq_TH2_Mouse1.02585603
109JUN_21703547_ChIP-Seq_K562_Human1.02463383
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02039266
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01958822
112* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01792270
113* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01102176
114* ER_23166858_ChIP-Seq_MCF-7_Human1.00614372
115* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00387739
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00211259
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.99892495
118* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99212179
119ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99209440
120GF1B_26923725_Chip-Seq_HPCs_Mouse0.99074854
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98394870
122* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98266353
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98094851
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96410731
125KDM2B_26808549_Chip-Seq_REH_Human0.96115193
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95683327
127TP53_22573176_ChIP-Seq_HFKS_Human0.95633992
128* TP53_20018659_ChIP-ChIP_R1E_Mouse0.95326261
129* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94153523
130P53_22387025_ChIP-Seq_ESCs_Mouse0.93943712
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93705244
132* GATA1_26923725_Chip-Seq_HPCs_Mouse0.93513104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium5.04756513
2MP0003787_abnormal_imprinting4.99036284
3MP0006292_abnormal_olfactory_placode4.96835836
4MP0005394_taste/olfaction_phenotype4.24705257
5MP0005499_abnormal_olfactory_system4.24705257
6MP0000778_abnormal_nervous_system3.15057514
7MP0000566_synostosis2.81695677
8MP0001188_hyperpigmentation2.60872326
9MP0010030_abnormal_orbit_morphology2.55895399
10MP0006276_abnormal_autonomic_nervous2.46061955
11MP0001529_abnormal_vocalization2.39793412
12MP0003121_genomic_imprinting2.38179045
13MP0005645_abnormal_hypothalamus_physiol2.23458560
14MP0000049_abnormal_middle_ear2.22283382
15MP0002822_catalepsy2.05690504
16MP0002233_abnormal_nose_morphology1.99825940
17MP0002249_abnormal_larynx_morphology1.99368547
18MP0000631_abnormal_neuroendocrine_gland1.84938669
19MP0002102_abnormal_ear_morphology1.82282466
20MP0008058_abnormal_DNA_repair1.81765591
21MP0003938_abnormal_ear_development1.75420607
22MP0006072_abnormal_retinal_apoptosis1.72958558
23MP0002736_abnormal_nociception_after1.71540336
24* MP0003755_abnormal_palate_morphology1.68832107
25MP0003880_abnormal_central_pattern1.66712332
26MP0002938_white_spotting1.66278429
27MP0003890_abnormal_embryonic-extraembry1.62648864
28MP0001968_abnormal_touch/_nociception1.62612157
29MP0001984_abnormal_olfaction1.61349127
30MP0005248_abnormal_Harderian_gland1.60965426
31* MP0003861_abnormal_nervous_system1.57116880
32MP0009745_abnormal_behavioral_response1.55285810
33* MP0002184_abnormal_innervation1.53829548
34MP0004885_abnormal_endolymph1.52595809
35MP0009046_muscle_twitch1.52294649
36MP0001293_anophthalmia1.51945960
37MP0002272_abnormal_nervous_system1.49667448
38MP0002638_abnormal_pupillary_reflex1.48908017
39MP0005253_abnormal_eye_physiology1.48840684
40MP0005551_abnormal_eye_electrophysiolog1.46785011
41MP0003937_abnormal_limbs/digits/tail_de1.44486193
42MP0000015_abnormal_ear_pigmentation1.44342037
43* MP0003385_abnormal_body_wall1.41374738
44MP0002177_abnormal_outer_ear1.41050229
45MP0005386_behavior/neurological_phenoty1.36901824
46MP0004924_abnormal_behavior1.36901824
47MP0005423_abnormal_somatic_nervous1.36137109
48MP0001286_abnormal_eye_development1.34604251
49* MP0002751_abnormal_autonomic_nervous1.33247544
50MP0004270_analgesia1.32061756
51MP0004133_heterotaxia1.30133608
52* MP0002116_abnormal_craniofacial_bone1.29532387
53MP0003942_abnormal_urinary_system1.29351532
54MP0002557_abnormal_social/conspecific_i1.27265492
55MP0009053_abnormal_anal_canal1.26202087
56MP0009250_abnormal_appendicular_skeleto1.25401794
57MP0008877_abnormal_DNA_methylation1.22054303
58MP0000569_abnormal_digit_pigmentation1.21692631
59MP0002152_abnormal_brain_morphology1.20861236
60MP0004811_abnormal_neuron_physiology1.20713099
61MP0002064_seizures1.19031979
62* MP0003935_abnormal_craniofacial_develop1.18922984
63MP0005646_abnormal_pituitary_gland1.18783192
64MP0002277_abnormal_respiratory_mucosa1.17057129
65MP0000537_abnormal_urethra_morphology1.15862721
66MP0002234_abnormal_pharynx_morphology1.14956648
67MP0001177_atelectasis1.13726980
68MP0005187_abnormal_penis_morphology1.13422318
69MP0004142_abnormal_muscle_tone1.12878642
70MP0005257_abnormal_intraocular_pressure1.12812883
71* MP0002081_perinatal_lethality1.12489650
72MP0008995_early_reproductive_senescence1.11305776
73MP0001970_abnormal_pain_threshold1.10384564
74MP0003567_abnormal_fetal_cardiomyocyte1.07864954
75MP0002733_abnormal_thermal_nociception1.07645147
76MP0002063_abnormal_learning/memory/cond1.05416376
77MP0003119_abnormal_digestive_system1.00489882
78MP0001485_abnormal_pinna_reflex1.00125551
79MP0002653_abnormal_ependyma_morphology0.99708278
80MP0000516_abnormal_urinary_system0.99229650
81MP0005367_renal/urinary_system_phenotyp0.99229650
82MP0000026_abnormal_inner_ear0.99150499
83MP0004742_abnormal_vestibular_system0.97884859
84MP0002697_abnormal_eye_size0.97884637
85MP0000428_abnormal_craniofacial_morphol0.97064865
86MP0005409_darkened_coat_color0.95008415
87MP0002160_abnormal_reproductive_system0.94199362
88MP0002282_abnormal_trachea_morphology0.93691868
89MP0000955_abnormal_spinal_cord0.92647324
90* MP0002882_abnormal_neuron_morphology0.92058072
91MP0001486_abnormal_startle_reflex0.90633206
92MP0005408_hypopigmentation0.90632512
93MP0000534_abnormal_ureter_morphology0.90403529
94MP0002734_abnormal_mechanical_nocicepti0.88720504
95MP0001324_abnormal_eye_pigmentation0.88233951
96MP0003315_abnormal_perineum_morphology0.87830782
97MP0002092_abnormal_eye_morphology0.87103634
98* MP0002752_abnormal_somatic_nervous0.85798521
99MP0001299_abnormal_eye_distance/0.85594362
100MP0003635_abnormal_synaptic_transmissio0.84314838
101MP0008007_abnormal_cellular_replicative0.83399395
102MP0002932_abnormal_joint_morphology0.83148726
103MP0000678_abnormal_parathyroid_gland0.82625542
104MP0003122_maternal_imprinting0.82184507
105MP0002069_abnormal_eating/drinking_beha0.81072012
106MP0002735_abnormal_chemical_nociception0.80902843
107MP0004145_abnormal_muscle_electrophysio0.80539238
108MP0002066_abnormal_motor_capabilities/c0.80234523
109MP0004859_abnormal_synaptic_plasticity0.79629135
110MP0003718_maternal_effect0.79373347
111MP0001963_abnormal_hearing_physiology0.79171418
112MP0003221_abnormal_cardiomyocyte_apopto0.79149496
113MP0002572_abnormal_emotion/affect_behav0.78107298
114MP0003011_delayed_dark_adaptation0.77609417
115MP0005171_absent_coat_pigmentation0.77149829
116* MP0000432_abnormal_head_morphology0.76938021
117* MP0002114_abnormal_axial_skeleton0.76665342
118MP0003698_abnormal_male_reproductive0.74474519
119MP0003137_abnormal_impulse_conducting0.72689355
120MP0001502_abnormal_circadian_rhythm0.69870005
121MP0005391_vision/eye_phenotype0.68639007
122MP0005195_abnormal_posterior_eye0.68266036
123MP0002067_abnormal_sensory_capabilities0.66161136
124MP0005197_abnormal_uvea_morphology0.65808810
125MP0010094_abnormal_chromosome_stability0.63877142
126MP0005389_reproductive_system_phenotype0.62322448
127MP0003115_abnormal_respiratory_system0.62161479
128MP0004858_abnormal_nervous_system0.60917079
129MP0010770_preweaning_lethality0.60744840
130MP0002082_postnatal_lethality0.60744840
131MP0008932_abnormal_embryonic_tissue0.60729161

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the sternum (HP:0006714)3.84124808
2Abnormality of the aortic arch (HP:0012303)3.48781377
3Morphological abnormality of the middle ear (HP:0008609)3.43673798
4Abnormality of the metopic suture (HP:0005556)3.40052923
5Nephronophthisis (HP:0000090)3.12210272
6Meningioma (HP:0002858)3.11420714
7Hepatoblastoma (HP:0002884)3.08509986
8Pancreatic cysts (HP:0001737)3.06110591
9Protruding tongue (HP:0010808)3.03001961
10* Abnormality of the intervertebral disk (HP:0005108)3.02140489
11Facial hemangioma (HP:0000329)3.00653646
12Pelvic girdle muscle weakness (HP:0003749)2.98795989
13Molar tooth sign on MRI (HP:0002419)2.91486992
14Abnormality of midbrain morphology (HP:0002418)2.91486992
15Broad-based gait (HP:0002136)2.91463191
16Abnormality of the phalanges of the hallux (HP:0010057)2.90835654
17Asymmetry of the thorax (HP:0001555)2.88220744
18Absent eyebrow (HP:0002223)2.85244705
19Hyperventilation (HP:0002883)2.84581926
20Absent speech (HP:0001344)2.82657020
21Intestinal atresia (HP:0011100)2.66133187
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64620759
23Tented upper lip vermilion (HP:0010804)2.64465544
24Febrile seizures (HP:0002373)2.63139756
25Short 4th metacarpal (HP:0010044)2.62848493
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62848493
27Abnormality of the hip-girdle musculature (HP:0001445)2.62521509
28Abnormality of the musculature of the pelvis (HP:0001469)2.62521509
29Abnormality of the renal medulla (HP:0100957)2.57962843
30Pendular nystagmus (HP:0012043)2.54136824
31Progressive sensorineural hearing impairment (HP:0000408)2.53220380
32Volvulus (HP:0002580)2.51979705
33Intellectual disability, moderate (HP:0002342)2.48424145
34Palpebral edema (HP:0100540)2.48298298
35Oligodactyly (hands) (HP:0001180)2.43483416
36Microglossia (HP:0000171)2.42846117
37Pancreatic fibrosis (HP:0100732)2.42250463
38Vaginal atresia (HP:0000148)2.40635457
39Focal seizures (HP:0007359)2.38096063
40Focal motor seizures (HP:0011153)2.37880819
41Benign neoplasm of the central nervous system (HP:0100835)2.37456607
42Amyotrophic lateral sclerosis (HP:0007354)2.37065507
43Natal tooth (HP:0000695)2.35913908
44Optic nerve hypoplasia (HP:0000609)2.33035205
45Lissencephaly (HP:0001339)2.32763312
46Thyroid-stimulating hormone excess (HP:0002925)2.31391202
47Progressive cerebellar ataxia (HP:0002073)2.29070462
48Abnormality of the nasal septum (HP:0000419)2.28866264
49* Slow-growing hair (HP:0002217)2.28066849
50* Abnormality of hair growth rate (HP:0011363)2.28066849
51Embryonal neoplasm (HP:0002898)2.25831008
52Abnormal lung lobation (HP:0002101)2.23752946
53Anencephaly (HP:0002323)2.22645307
54Polyphagia (HP:0002591)2.21415352
55Alacrima (HP:0000522)2.20833446
56Deep philtrum (HP:0002002)2.20528489
57Cortical dysplasia (HP:0002539)2.19531620
58Sclerocornea (HP:0000647)2.18804356
59Narrow forehead (HP:0000341)2.18641168
60Inability to walk (HP:0002540)2.18435693
61Thickened helices (HP:0000391)2.18099474
62Midline defect of the nose (HP:0004122)2.16917186
63Abnormality of the labia minora (HP:0012880)2.16682123
64Retinal dysplasia (HP:0007973)2.15528906
65Broad alveolar ridges (HP:0000187)2.15467056
66Facial cleft (HP:0002006)2.14781008
67Shoulder girdle muscle weakness (HP:0003547)2.13161035
68Wrist flexion contracture (HP:0001239)2.12574856
69Preaxial hand polydactyly (HP:0001177)2.12326436
70Ectopic kidney (HP:0000086)2.10049479
71Postaxial foot polydactyly (HP:0001830)2.09900162
72Capillary hemangiomas (HP:0005306)2.09371485
73Absent eyelashes (HP:0000561)2.08500220
74Scrotal hypoplasia (HP:0000046)2.08432197
75Specific learning disability (HP:0001328)2.07276579
76Abnormal hair whorl (HP:0010721)2.06163411
77Adrenal hypoplasia (HP:0000835)2.05900748
78Cupped ear (HP:0000378)2.05846846
79Gait imbalance (HP:0002141)2.04692756
80Pachygyria (HP:0001302)2.03897180
81Cystic liver disease (HP:0006706)2.03233988
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03020134
83Labial hypoplasia (HP:0000066)2.02953254
84Trigonocephaly (HP:0000243)2.01927394
85Renal hypoplasia (HP:0000089)2.01078398
86Gastroesophageal reflux (HP:0002020)1.99322725
87Hypothermia (HP:0002045)1.98020128
88Nephrogenic diabetes insipidus (HP:0009806)1.97990308
89Megalencephaly (HP:0001355)1.96948622
90Advanced eruption of teeth (HP:0006288)1.96797299
91Congenital stationary night blindness (HP:0007642)1.96432816
92Agitation (HP:0000713)1.93780609
93Progressive inability to walk (HP:0002505)1.93297277
94Germ cell neoplasia (HP:0100728)1.93190405
95Medial flaring of the eyebrow (HP:0010747)1.92851496
96Decreased lacrimation (HP:0000633)1.92450537
97Obstructive sleep apnea (HP:0002870)1.91890019
98Shallow orbits (HP:0000586)1.90700322
99True hermaphroditism (HP:0010459)1.90444287
100* Spina bifida occulta (HP:0003298)1.90124109
101Abnormality of salivation (HP:0100755)1.89971102
102Limb dystonia (HP:0002451)1.89819251
103Cutaneous syndactyly (HP:0012725)1.89790022
104Chromsome breakage (HP:0040012)1.88160947
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88158933
106Poor coordination (HP:0002370)1.87690701
107Dyskinesia (HP:0100660)1.87581169
108Long clavicles (HP:0000890)1.87552683
109Choanal stenosis (HP:0000452)1.87183805
110Cutaneous finger syndactyly (HP:0010554)1.86658511
111Hip dysplasia (HP:0001385)1.86639177
112Hyperglycinemia (HP:0002154)1.85933760
113Curly hair (HP:0002212)1.85646752
114Abnormality of the antihelix (HP:0009738)1.85460366
115* Patellar aplasia (HP:0006443)1.85212548
116Hypoplastic female external genitalia (HP:0012815)1.84477721
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.83847202
118Anophthalmia (HP:0000528)1.83723944
119Type II lissencephaly (HP:0007260)1.82945483
120Hamartoma (HP:0010566)1.82461583
121Wide cranial sutures (HP:0010537)1.82242601
122Micropenis (HP:0000054)1.81505240
123Chronic hepatic failure (HP:0100626)1.81096512
124Congenital primary aphakia (HP:0007707)1.80894844
125Postaxial hand polydactyly (HP:0001162)1.80528965
126Nephroblastoma (Wilms tumor) (HP:0002667)1.80366022
127Fetal akinesia sequence (HP:0001989)1.80275052
128Decreased testicular size (HP:0008734)1.80138613
129Hypsarrhythmia (HP:0002521)1.79729075
130Exotropia (HP:0000577)1.79610264
131Tracheomalacia (HP:0002779)1.78793507
132Polymicrogyria (HP:0002126)1.77894318
133Septo-optic dysplasia (HP:0100842)1.77777680
134Embryonal renal neoplasm (HP:0011794)1.77533232
135Abnormality of incisor morphology (HP:0011063)1.77105844
136Small hand (HP:0200055)1.76907024
137Bicornuate uterus (HP:0000813)1.76288025
138* Aplasia/Hypoplasia of the patella (HP:0006498)1.75391605
139Bilateral microphthalmos (HP:0007633)1.74782048
140Oligodactyly (HP:0012165)1.74654771
141Colon cancer (HP:0003003)1.74399902
142Genital tract atresia (HP:0001827)1.74056358
143Myelomeningocele (HP:0002475)1.73807842
144Rimmed vacuoles (HP:0003805)1.73687868
145Abnormality of the 4th metacarpal (HP:0010012)1.73158130
146Open mouth (HP:0000194)1.72863429
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72381083
148Hypoplasia of the brainstem (HP:0002365)1.72381083
149Abnormality of the pubic bones (HP:0003172)1.72103786
150Methylmalonic acidemia (HP:0002912)1.71436073
151Stereotypic behavior (HP:0000733)1.71395670
152Short 1st metacarpal (HP:0010034)1.71388575
153Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.71388575
154Excessive salivation (HP:0003781)1.71159183
155Drooling (HP:0002307)1.71159183
156Short foot (HP:0001773)1.70373556
157Growth hormone deficiency (HP:0000824)1.68258215
158High anterior hairline (HP:0009890)1.68015266
159Astigmatism (HP:0000483)1.67454805
160Vitreoretinal degeneration (HP:0000655)1.67216112
161EEG with generalized epileptiform discharges (HP:0011198)1.66679643
162Aganglionic megacolon (HP:0002251)1.65741950
163Abnormality of the renal cortex (HP:0011035)1.64422077
164Occipital encephalocele (HP:0002085)1.63938581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB34.94491255
2MARK14.70545582
3AKT33.64317071
4PLK43.57750755
5TRIM283.34163576
6SRPK13.11728434
7MAP4K23.11308684
8MAPK132.83483669
9YES12.80856188
10CASK2.76388078
11BMPR22.74282780
12SGK22.68963041
13PRPF4B2.65269035
14MAP2K72.59808633
15DYRK22.56553003
16SGK2232.16420822
17SGK4942.16420822
18FRK2.09055450
19MAP3K42.00360805
20SGK31.73631864
21PLK21.71179358
22EPHA41.70289693
23EPHB21.66778242
24NTRK21.55068673
25UHMK11.46716812
26SIK21.43684236
27MKNK11.38026384
28VRK11.35397011
29NUAK11.31145382
30PLK31.30075076
31WNK31.28107871
32SIK31.26822291
33PAK31.23906871
34BRAF1.23605215
35PNCK1.23028224
36EPHA31.18558328
37INSRR1.11951137
38GRK11.10266537
39BMPR1B1.04687839
40LATS11.03721074
41RPS6KA21.03628657
42CAMK41.03174770
43CCNB10.98281252
44KSR10.97948521
45MKNK20.95378638
46ADRBK20.95225427
47ZAK0.91401107
48LIMK10.84836303
49BRD40.83618219
50DYRK30.79850014
51BCR0.79685332
52MAP2K40.79544267
53RPS6KA40.78083630
54CAMK1G0.74303806
55EIF2AK20.72136348
56PRKCE0.69860683
57DYRK1A0.69527516
58ROCK10.66026567
59STK38L0.64734307
60BUB10.64686047
61PKN10.63928867
62RPS6KB10.62439343
63MINK10.59115809
64OXSR10.58722018
65MARK20.57787698
66CDK30.57353455
67* MAPK80.57335157
68MAP3K60.56383794
69CAMK1D0.55317020
70CSNK1G20.54466409
71TNIK0.53908585
72AURKA0.52621264
73CDK10.51859583
74CAMK2A0.51331111
75CAMK2B0.51167191
76CDK50.50598643
77PRKCG0.50003330
78CSNK1A10.48602022
79CAMKK20.48291275
80STK240.48248520
81CSNK1G30.48008225
82CSNK1D0.45286386
83DAPK20.44970114
84MAPK90.44158439
85WEE10.44041212
86STK390.42642657
87EEF2K0.42363794
88CDK140.41791182
89CDC70.41050895
90CAMK10.40077834
91BCKDK0.39674403
92PRKCH0.39462489
93ATR0.38919667
94CSNK1A1L0.38811583
95* GSK3B0.38746348
96SGK10.38719900
97PRKAA10.38694601
98ERBB20.38681162
99PRKACA0.38305204
100DYRK1B0.38302446
101RPS6KL10.37430964
102RPS6KC10.37430964
103CHEK20.37390871
104PAK60.36929492
105PINK10.34800356
106STK110.34439972
107ADRBK10.34287506
108CSNK1E0.33917682
109CHEK10.33843729
110CSNK1G10.33171813
111RPS6KA60.32738750
112MAPK40.31655138
113MAPK140.31515736
114PRKCZ0.31486731
115CDK190.31375951
116NTRK30.30421178
117GSK3A0.29752214
118PRKDC0.29623853
119CDK150.29497993
120* CDK20.29000788
121AKT10.28871507
122PRKG10.28398258
123ACVR1B0.27880212
124PLK10.27854774
125CDK11A0.26562070
126ATM0.26379291
127BRSK10.25981978
128ROCK20.25702739
129CHUK0.25398281
130CDK180.25291875
131FGFR20.25196332
132PHKG10.25029180
133PHKG20.25029180
134RPS6KA10.24812404
135RPS6KA50.24242878

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.94215136
2Spliceosome_Homo sapiens_hsa030402.74433817
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47626439
4Olfactory transduction_Homo sapiens_hsa047402.29667982
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28066732
6Phototransduction_Homo sapiens_hsa047442.25554217
7Fanconi anemia pathway_Homo sapiens_hsa034602.17563517
8Protein export_Homo sapiens_hsa030602.13399149
9Basal cell carcinoma_Homo sapiens_hsa052172.13327026
10Hedgehog signaling pathway_Homo sapiens_hsa043402.13173585
11mRNA surveillance pathway_Homo sapiens_hsa030152.08577305
12Endometrial cancer_Homo sapiens_hsa052132.03563167
13One carbon pool by folate_Homo sapiens_hsa006701.94618816
14Base excision repair_Homo sapiens_hsa034101.89290679
15Colorectal cancer_Homo sapiens_hsa052101.85995526
16Notch signaling pathway_Homo sapiens_hsa043301.82878398
17Serotonergic synapse_Homo sapiens_hsa047261.81920132
18Nicotine addiction_Homo sapiens_hsa050331.69327599
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68709156
20Wnt signaling pathway_Homo sapiens_hsa043101.66542856
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63541846
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63462105
23Propanoate metabolism_Homo sapiens_hsa006401.57802657
24ErbB signaling pathway_Homo sapiens_hsa040121.54186337
25Cell cycle_Homo sapiens_hsa041101.51149260
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46191159
27Lysine degradation_Homo sapiens_hsa003101.45842036
28Mismatch repair_Homo sapiens_hsa034301.44333532
29Dopaminergic synapse_Homo sapiens_hsa047281.44316567
30Non-homologous end-joining_Homo sapiens_hsa034501.42216184
31Taste transduction_Homo sapiens_hsa047421.42186097
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34853808
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.34799433
34Morphine addiction_Homo sapiens_hsa050321.31365829
35Homologous recombination_Homo sapiens_hsa034401.28851808
36FoxO signaling pathway_Homo sapiens_hsa040681.28793565
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28245416
38Linoleic acid metabolism_Homo sapiens_hsa005911.27768567
39Alcoholism_Homo sapiens_hsa050341.24909851
40Cholinergic synapse_Homo sapiens_hsa047251.24580178
41Hippo signaling pathway_Homo sapiens_hsa043901.20313351
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17430126
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16819773
44Glutamatergic synapse_Homo sapiens_hsa047241.16165945
45Nucleotide excision repair_Homo sapiens_hsa034201.15207882
46Ether lipid metabolism_Homo sapiens_hsa005651.13929149
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11682089
48RNA transport_Homo sapiens_hsa030131.09646501
49DNA replication_Homo sapiens_hsa030301.08710545
50Circadian entrainment_Homo sapiens_hsa047131.08121895
51GABAergic synapse_Homo sapiens_hsa047271.07207718
52MicroRNAs in cancer_Homo sapiens_hsa052061.07189304
53Oxidative phosphorylation_Homo sapiens_hsa001901.05631165
54Basal transcription factors_Homo sapiens_hsa030221.04972954
55RNA polymerase_Homo sapiens_hsa030201.03794860
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02631202
57RNA degradation_Homo sapiens_hsa030181.00596413
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99402163
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98733699
60Caffeine metabolism_Homo sapiens_hsa002320.95966378
61Prostate cancer_Homo sapiens_hsa052150.95680764
62Parkinsons disease_Homo sapiens_hsa050120.95022075
63Selenocompound metabolism_Homo sapiens_hsa004500.94644938
64Adherens junction_Homo sapiens_hsa045200.93862627
65Tryptophan metabolism_Homo sapiens_hsa003800.93805313
66Insulin secretion_Homo sapiens_hsa049110.92715044
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90280041
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89830403
69Melanoma_Homo sapiens_hsa052180.89280088
70Melanogenesis_Homo sapiens_hsa049160.88616349
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87892768
72Long-term depression_Homo sapiens_hsa047300.86531188
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.86137989
74Nitrogen metabolism_Homo sapiens_hsa009100.85807735
75Chronic myeloid leukemia_Homo sapiens_hsa052200.85463012
76Prolactin signaling pathway_Homo sapiens_hsa049170.85054004
77Collecting duct acid secretion_Homo sapiens_hsa049660.84274454
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84026753
79Glioma_Homo sapiens_hsa052140.83172747
80Regulation of autophagy_Homo sapiens_hsa041400.80566285
81Epstein-Barr virus infection_Homo sapiens_hsa051690.78500090
82Renal cell carcinoma_Homo sapiens_hsa052110.77342368
83Cardiac muscle contraction_Homo sapiens_hsa042600.76567670
84MAPK signaling pathway_Homo sapiens_hsa040100.76210319
85Steroid biosynthesis_Homo sapiens_hsa001000.74986974
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74583911
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71035132
88Salivary secretion_Homo sapiens_hsa049700.70346500
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69713660
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68280200
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67935576
92Ras signaling pathway_Homo sapiens_hsa040140.66478327
93Pathways in cancer_Homo sapiens_hsa052000.66123957
94Huntingtons disease_Homo sapiens_hsa050160.65099310
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64825545
96Non-small cell lung cancer_Homo sapiens_hsa052230.64789627
97Peroxisome_Homo sapiens_hsa041460.64727818
98Retinol metabolism_Homo sapiens_hsa008300.64571064
99Gap junction_Homo sapiens_hsa045400.64168924
100Pancreatic cancer_Homo sapiens_hsa052120.63411303
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62997291
102Viral myocarditis_Homo sapiens_hsa054160.62808767
103cAMP signaling pathway_Homo sapiens_hsa040240.61872961
104beta-Alanine metabolism_Homo sapiens_hsa004100.61652921
105Hepatitis C_Homo sapiens_hsa051600.61092420
106Cocaine addiction_Homo sapiens_hsa050300.60140640
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59978484
108Tight junction_Homo sapiens_hsa045300.59819714
109Systemic lupus erythematosus_Homo sapiens_hsa053220.58443206
110Long-term potentiation_Homo sapiens_hsa047200.58321982
111Thyroid cancer_Homo sapiens_hsa052160.57984802
112TGF-beta signaling pathway_Homo sapiens_hsa043500.54324369
113HTLV-I infection_Homo sapiens_hsa051660.53238455
114Fatty acid metabolism_Homo sapiens_hsa012120.52635770
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.52232691
116Fatty acid elongation_Homo sapiens_hsa000620.51533516
117Chemical carcinogenesis_Homo sapiens_hsa052040.51002979
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50124765
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48691315
120Circadian rhythm_Homo sapiens_hsa047100.48197606
121Ovarian steroidogenesis_Homo sapiens_hsa049130.48167943
122Butanoate metabolism_Homo sapiens_hsa006500.47729535
123Alzheimers disease_Homo sapiens_hsa050100.47596286
124ABC transporters_Homo sapiens_hsa020100.47165085
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.45756765
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45504414
127Calcium signaling pathway_Homo sapiens_hsa040200.45315994
128T cell receptor signaling pathway_Homo sapiens_hsa046600.45098137
129Viral carcinogenesis_Homo sapiens_hsa052030.44366146
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44058352
131Autoimmune thyroid disease_Homo sapiens_hsa053200.42934254
132p53 signaling pathway_Homo sapiens_hsa041150.42437742
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42017501
134Gastric acid secretion_Homo sapiens_hsa049710.42009418
135Glycerolipid metabolism_Homo sapiens_hsa005610.40245704
136Renin secretion_Homo sapiens_hsa049240.39429507
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38446356
138Fat digestion and absorption_Homo sapiens_hsa049750.38390897
139Oxytocin signaling pathway_Homo sapiens_hsa049210.38225015
140GnRH signaling pathway_Homo sapiens_hsa049120.37740775
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36923887
142Amphetamine addiction_Homo sapiens_hsa050310.36810715
143Oocyte meiosis_Homo sapiens_hsa041140.36389106
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36022601
145Synaptic vesicle cycle_Homo sapiens_hsa047210.35375805
146Bladder cancer_Homo sapiens_hsa052190.35263196
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34326476

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