SORBS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)4.31323314
2adhesion of symbiont to host cell (GO:0044650)3.75801155
3virion attachment to host cell (GO:0019062)3.75801155
4blood vessel maturation (GO:0001955)3.69114510
5basement membrane organization (GO:0071711)3.67540790
6vascular endothelial growth factor signaling pathway (GO:0038084)3.47922361
7renal filtration (GO:0097205)3.39403352
8alpha-linolenic acid metabolic process (GO:0036109)3.38647239
9glomerular filtration (GO:0003094)3.36814671
10protein retention in ER lumen (GO:0006621)3.35162491
11glomerular basement membrane development (GO:0032836)3.35137070
12tooth mineralization (GO:0034505)3.33238431
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32083008
14regulation of extracellular matrix disassembly (GO:0010715)3.23942033
15extracellular fibril organization (GO:0043206)3.22244747
16apoptotic cell clearance (GO:0043277)3.20392097
17lymphangiogenesis (GO:0001946)3.16850853
18surfactant homeostasis (GO:0043129)3.13244365
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.11018361
20skin morphogenesis (GO:0043589)3.10867787
21regulation of early endosome to late endosome transport (GO:2000641)3.07363651
22cytoskeletal anchoring at plasma membrane (GO:0007016)3.07054077
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07005759
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06644005
25endothelial cell chemotaxis (GO:0035767)3.06158530
26hyaluronan catabolic process (GO:0030214)3.05524180
27cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.05325538
28positive regulation of extracellular matrix organization (GO:1903055)3.04849623
29fibril organization (GO:0097435)3.04410287
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.00966390
31cell-cell junction maintenance (GO:0045217)3.00151226
32endothelial cell morphogenesis (GO:0001886)2.97403343
33protein localization to endosome (GO:0036010)2.96191054
34adherens junction assembly (GO:0034333)2.93437447
35cell volume homeostasis (GO:0006884)2.91653147
36extracellular matrix assembly (GO:0085029)2.90376688
37endocardial cushion development (GO:0003197)2.90245576
38branching involved in salivary gland morphogenesis (GO:0060445)2.86737925
39atrioventricular valve morphogenesis (GO:0003181)2.83726120
40lymph vessel development (GO:0001945)2.82924593
41positive regulation of fatty acid beta-oxidation (GO:0032000)2.82714316
42positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.82697095
43adhesion of symbiont to host (GO:0044406)2.82519228
44retina vasculature morphogenesis in camera-type eye (GO:0061299)2.79272750
45collagen metabolic process (GO:0032963)2.78698218
46negative regulation of smooth muscle cell migration (GO:0014912)2.77710104
47mannose metabolic process (GO:0006013)2.77656961
48peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.77617974
49regulation of cholesterol homeostasis (GO:2000188)2.76913311
50kidney mesenchyme development (GO:0072074)2.74522904
51cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.73734778
52regulation of skeletal muscle contraction (GO:0014819)2.70955185
53regulation of endothelial cell chemotaxis (GO:2001026)2.69876666
54cell-substrate adherens junction assembly (GO:0007045)2.69244183
55focal adhesion assembly (GO:0048041)2.69244183
56response to mercury ion (GO:0046689)2.68325756
57sexual reproduction (GO:0019953)2.68031196
58multicellular organismal macromolecule metabolic process (GO:0044259)2.66977794
59response to acidic pH (GO:0010447)2.66950490
60sperm capacitation (GO:0048240)2.66438618
61epoxygenase P450 pathway (GO:0019373)2.66017884
62collagen catabolic process (GO:0030574)2.65880847
63protein heterotrimerization (GO:0070208)2.64885179
64venous blood vessel morphogenesis (GO:0048845)2.64233016
65plasma membrane repair (GO:0001778)2.63980575
66semaphorin-plexin signaling pathway (GO:0071526)2.61803243
67negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61329336
68positive regulation of triglyceride biosynthetic process (GO:0010867)2.60490798
69cell migration involved in heart development (GO:0060973)2.59947205
70positive regulation of receptor recycling (GO:0001921)2.59872110
71ethanol oxidation (GO:0006069)2.59062483
72regulation of cardioblast differentiation (GO:0051890)2.58364749
73fibroblast migration (GO:0010761)2.58305491
74positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57897102
75negative regulation of fibrinolysis (GO:0051918)2.56491243
76pinocytosis (GO:0006907)2.56012813
77extracellular matrix disassembly (GO:0022617)2.55594900
78peptidyl-proline hydroxylation (GO:0019511)2.55053185
79multicellular organismal catabolic process (GO:0044243)2.52809102
80positive regulation of fatty acid oxidation (GO:0046321)2.52207603
81regulation of extracellular matrix organization (GO:1903053)2.52196067
82keratan sulfate catabolic process (GO:0042340)2.52158938
83positive regulation of glycogen biosynthetic process (GO:0045725)2.51683521
84chondrocyte proliferation (GO:0035988)2.51440570
85UV protection (GO:0009650)2.50938851
86myelination in peripheral nervous system (GO:0022011)2.50735753
87peripheral nervous system axon ensheathment (GO:0032292)2.50735753
88complement activation, alternative pathway (GO:0006957)2.50252822
89multicellular organismal metabolic process (GO:0044236)2.49744006
90cochlea morphogenesis (GO:0090103)2.49343725
91regulation of endothelial cell differentiation (GO:0045601)2.49335771
92embryo implantation (GO:0007566)2.48891356
93cortical actin cytoskeleton organization (GO:0030866)2.46007915
94cellular response to pH (GO:0071467)2.45865361
95regulation of complement activation (GO:0030449)2.44968383
96metanephric mesenchyme development (GO:0072075)2.43974315
97L-phenylalanine catabolic process (GO:0006559)2.43239166
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.43239166
99negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.42516686
100cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.42372043
101positive regulation of endothelial cell apoptotic process (GO:2000353)2.41598665
102regulation of protein activation cascade (GO:2000257)2.40947801
103sulfur amino acid catabolic process (GO:0000098)2.39392824
104regulation of plasminogen activation (GO:0010755)2.39221406
105chondroitin sulfate catabolic process (GO:0030207)2.39101836
106fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.39062098
107vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.38549065
108blood vessel endothelial cell migration (GO:0043534)2.38521417
109epithelial cell-cell adhesion (GO:0090136)2.38488984
110toxin metabolic process (GO:0009404)2.38354874
111cell migration involved in sprouting angiogenesis (GO:0002042)2.38251921
112L-phenylalanine metabolic process (GO:0006558)2.37627136
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37627136
114regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.37349574
115cortical cytoskeleton organization (GO:0030865)2.37025729
116fatty acid transmembrane transport (GO:1902001)2.36513971
117positive regulation of triglyceride metabolic process (GO:0090208)2.35699518
118stress fiber assembly (GO:0043149)2.35600327
119collagen fibril organization (GO:0030199)2.35441743
120negative regulation of catenin import into nucleus (GO:0035414)2.35276022
121hormone catabolic process (GO:0042447)2.34611721
122carnitine shuttle (GO:0006853)2.34555781
123cell proliferation involved in metanephros development (GO:0072203)2.34176973
124regulation of p38MAPK cascade (GO:1900744)2.34157949
125glycosaminoglycan catabolic process (GO:0006027)2.34013762
126lung lobe morphogenesis (GO:0060463)2.33757972
127bone trabecula formation (GO:0060346)2.32271846
128regulation of fatty acid beta-oxidation (GO:0031998)2.31418847
129regulation of apoptotic cell clearance (GO:2000425)2.31133849
130regulation of fatty acid oxidation (GO:0046320)2.30841210
131high-density lipoprotein particle remodeling (GO:0034375)2.30720796
132substrate adhesion-dependent cell spreading (GO:0034446)2.30677929
133fatty acid beta-oxidation (GO:0006635)2.30600811
134negative regulation of chondrocyte differentiation (GO:0032331)2.30419071
135regulation of ARF GTPase activity (GO:0032312)2.30073956
136neuron projection extension involved in neuron projection guidance (GO:1902284)2.29568027
137axon extension involved in axon guidance (GO:0048846)2.29568027
138regulation of apoptotic process involved in morphogenesis (GO:1902337)2.29445016
139xenobiotic catabolic process (GO:0042178)2.29330783
140heart trabecula formation (GO:0060347)2.29175229
141regulation of membrane protein ectodomain proteolysis (GO:0051043)2.28582817
142sarcomere organization (GO:0045214)2.28222792
143reverse cholesterol transport (GO:0043691)2.28202207
144cardiac myofibril assembly (GO:0055003)2.28190818
145positive regulation of Rho protein signal transduction (GO:0035025)2.27640870
146type B pancreatic cell proliferation (GO:0044342)2.27493485
147endocytic recycling (GO:0032456)2.27409170
148insulin-like growth factor receptor signaling pathway (GO:0048009)2.27260473
149hemidesmosome assembly (GO:0031581)2.27098914
150negative regulation of heart growth (GO:0061117)2.27020701
151negative regulation of cardiac muscle tissue growth (GO:0055022)2.27020701
152positive regulation of glycogen metabolic process (GO:0070875)2.26874891
153endodermal cell differentiation (GO:0035987)2.26228576
154negative regulation of cartilage development (GO:0061037)2.25240097
155cell-substrate junction assembly (GO:0007044)2.25087392
156low-density lipoprotein particle clearance (GO:0034383)2.24582864
157response to laminar fluid shear stress (GO:0034616)2.24253542
158regulation of glucose import in response to insulin stimulus (GO:2001273)2.24064322
159triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.23864207
160lysine catabolic process (GO:0006554)2.23331482
161lysine metabolic process (GO:0006553)2.23331482
162receptor recycling (GO:0001881)2.22797221
163regulation of cholesterol biosynthetic process (GO:0045540)2.22165073
164protein carboxylation (GO:0018214)2.22130377
165peptidyl-glutamic acid carboxylation (GO:0017187)2.22130377
166regulation of T-helper 2 cell differentiation (GO:0045628)2.21941980
167positive regulation of p38MAPK cascade (GO:1900745)2.21219832
168cellular response to growth hormone stimulus (GO:0071378)2.21082936
169opsonization (GO:0008228)2.20188437
170regulation of cholesterol metabolic process (GO:0090181)2.19906247
171morphogenesis of an endothelium (GO:0003159)2.18983016
172endothelial tube morphogenesis (GO:0061154)2.18983016
173positive regulation of blood coagulation (GO:0030194)2.18056338
174positive regulation of hemostasis (GO:1900048)2.18056338
175plasma lipoprotein particle clearance (GO:0034381)2.18032808
176midgut development (GO:0007494)2.17779566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.37112503
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.88193861
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.58668190
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.50946150
5* RXR_22158963_ChIP-Seq_LIVER_Mouse2.95528852
6CLOCK_20551151_ChIP-Seq_293T_Human2.90209053
7* LXR_22158963_ChIP-Seq_LIVER_Mouse2.67232319
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54529021
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.49326007
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.41351735
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.31900312
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16530697
13* GATA2_21666600_ChIP-Seq_HMVEC_Human2.15098229
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.12165481
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09037945
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05779991
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.05451353
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04331089
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96958089
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93390710
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92714413
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85799688
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.84726618
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.77497359
25TBX20_22328084_ChIP-Seq_HEART_Mouse1.77010669
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.77010669
27* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76234991
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73709157
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69285149
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65314401
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63857408
32CTCF_27219007_Chip-Seq_Bcells_Human1.61238739
33SMC4_20622854_ChIP-Seq_HELA_Human1.60962242
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.60779173
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60162496
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58931471
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.58128336
38P68_20966046_ChIP-Seq_HELA_Human1.55912233
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.55438640
40VDR_21846776_ChIP-Seq_THP-1_Human1.52886532
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52060106
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49867112
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.48326382
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46633022
45TCF7_22412390_ChIP-Seq_EML_Mouse1.46546085
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43799258
47TP53_22127205_ChIP-Seq_IMR90_Human1.41908382
48CJUN_26792858_Chip-Seq_BT549_Human1.41152074
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37976197
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.37440697
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37306414
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35352916
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33322541
54* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33233068
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31490612
56* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30625079
57RACK7_27058665_Chip-Seq_MCF-7_Human1.28895586
58* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27661648
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26208649
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25912215
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25787604
62TP63_22573176_ChIP-Seq_HFKS_Human1.25395260
63* LXR_22292898_ChIP-Seq_THP-1_Human1.24988494
64* FOXA2_19822575_ChIP-Seq_HepG2_Human1.24751562
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.24383180
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23773114
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.20692241
68* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20076095
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18509413
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.15999087
71CREB1_26743006_Chip-Seq_LNCaP_Human1.15824340
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15251869
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14520578
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14142876
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13372353
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12502164
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12502164
78* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11539528
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10634336
80BCL6_27268052_Chip-Seq_Bcells_Human1.09802170
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09724976
82* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07975484
83ZNF263_19887448_ChIP-Seq_K562_Human1.07083914
84BCOR_27268052_Chip-Seq_Bcells_Human1.07077750
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06497666
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05788494
87GATA1_19941826_ChIP-Seq_K562_Human1.05633078
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05223066
89ATF3_27146783_Chip-Seq_COLON_Human1.04848405
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03570417
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02966468
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02430396
93SA1_27219007_Chip-Seq_Bcells_Human1.01720411
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00361939
95SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00306381
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00126464
97P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99761539
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98972545
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97916175
100JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95944204
101KDM2B_26808549_Chip-Seq_K562_Human0.95810698
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95667932
103* VDR_24763502_ChIP-Seq_THP-1_Human0.95414462
104CTCF_20526341_ChIP-Seq_ESCs_Human0.95376997
105SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94742013
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94631486
107* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94109081
108SOX2_20726797_ChIP-Seq_SW620_Human0.94051785
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93858506
110EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93788014
111JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93576111
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93435745
113DROSHA_22980978_ChIP-Seq_HELA_Human0.93133160
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92648957
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92457478
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92207170
117MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92165707
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90539152
119BP1_19119308_ChIP-ChIP_Hs578T_Human0.90273702
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89424465
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.89215882
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89094844
123EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89094844
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87443716
125EED_16625203_ChIP-ChIP_MESCs_Mouse0.87283465
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87171812
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85716201
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85716201
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84794608
130KDM2B_26808549_Chip-Seq_DND41_Human0.84412738
131ISL1_27105846_Chip-Seq_CPCs_Mouse0.84146281
132GATA2_19941826_ChIP-Seq_K562_Human0.84015956
133AHR_22903824_ChIP-Seq_MCF-7_Human0.83466017
134CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83453938
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83278284
136UBF1/2_26484160_Chip-Seq_HMECs_Human0.81620014
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.81302246
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80488567
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79852379
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79539568
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.78935788
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.78725761
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77730655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.38296932
2MP0008438_abnormal_cutaneous_collagen4.14784555
3MP0004272_abnormal_basement_membrane3.34284294
4MP0003705_abnormal_hypodermis_morpholog3.15067774
5MP0005257_abnormal_intraocular_pressure2.81601017
6MP0003279_aneurysm2.80353264
7MP0001958_emphysema2.72729657
8MP0005503_abnormal_tendon_morphology2.69326505
9MP0001879_abnormal_lymphatic_vessel2.47329586
10MP0005275_abnormal_skin_tensile2.21464754
11MP0000751_myopathy2.09992884
12MP0008875_abnormal_xenobiotic_pharmacok2.09479187
13MP0001849_ear_inflammation2.07594564
14MP0003191_abnormal_cellular_cholesterol2.07398606
15MP0004084_abnormal_cardiac_muscle2.03486419
16MP0009384_cardiac_valve_regurgitation1.99098170
17MP0005623_abnormal_meninges_morphology1.98108056
18MP0005670_abnormal_white_adipose1.93024807
19MP0009840_abnormal_foam_cell1.89928293
20MP0005365_abnormal_bile_salt1.86684457
21MP0004858_abnormal_nervous_system1.85885856
22MP0003566_abnormal_cell_adhesion1.78434282
23MP0002139_abnormal_hepatobiliary_system1.70421082
24MP0005410_abnormal_fertilization1.68129605
25MP0004036_abnormal_muscle_relaxation1.67491605
26MP0003950_abnormal_plasma_membrane1.66765502
27MP0000678_abnormal_parathyroid_gland1.64198363
28MP0000767_abnormal_smooth_muscle1.61262129
29MP0006138_congestive_heart_failure1.60840731
30MP0000749_muscle_degeneration1.59478664
31MP0005360_urolithiasis1.53431785
32MP0001348_abnormal_lacrimal_gland1.48582534
33MP0001542_abnormal_bone_strength1.47997068
34MP0009278_abnormal_bone_marrow1.47533084
35MP0006054_spinal_hemorrhage1.47172319
36MP0003172_abnormal_lysosome_physiology1.46302286
37MP0010030_abnormal_orbit_morphology1.45020293
38MP0003329_amyloid_beta_deposits1.43244538
39MP0002295_abnormal_pulmonary_circulatio1.41371290
40MP0002108_abnormal_muscle_morphology1.39629478
41MP0005409_darkened_coat_color1.39612188
42MP0004087_abnormal_muscle_fiber1.39382103
43MP0005330_cardiomyopathy1.35774578
44MP0005451_abnormal_body_composition1.35668613
45MP0010329_abnormal_lipoprotein_level1.33098343
46MP0003828_pulmonary_edema1.32992667
47MP0009780_abnormal_chondrocyte_physiolo1.32282844
48MP0010630_abnormal_cardiac_muscle1.29692510
49MP0005167_abnormal_blood-brain_barrier1.27831383
50MP0002998_abnormal_bone_remodeling1.27250122
51MP0000733_abnormal_muscle_development1.26027053
52MP0002128_abnormal_blood_circulation1.25540541
53MP0002837_dystrophic_cardiac_calcinosis1.25375787
54MP0004130_abnormal_muscle_cell1.24879912
55MP0004510_myositis1.24285800
56MP0002933_joint_inflammation1.20977308
57MP0001544_abnormal_cardiovascular_syste1.20080720
58MP0005385_cardiovascular_system_phenoty1.20080720
59MP0005085_abnormal_gallbladder_physiolo1.19093497
60MP0005508_abnormal_skeleton_morphology1.19037460
61MP0000750_abnormal_muscle_regeneration1.18883480
62MP0000534_abnormal_ureter_morphology1.16555076
63MP0005595_abnormal_vascular_smooth1.14145309
64MP0000604_amyloidosis1.13730303
65MP0003075_altered_response_to1.10347704
66MP0005390_skeleton_phenotype1.10153860
67MP0003252_abnormal_bile_duct1.07405007
68* MP0003091_abnormal_cell_migration1.06258783
69MP0005083_abnormal_biliary_tract1.03218668
70MP0003115_abnormal_respiratory_system1.02434106
71MP0003453_abnormal_keratinocyte_physiol1.02103360
72MP0001614_abnormal_blood_vessel1.02065194
73MP0000343_altered_response_to1.02016732
74MP0005666_abnormal_adipose_tissue1.00604916
75MP0003879_abnormal_hair_cell1.00594909
76MP0002269_muscular_atrophy1.00275343
77MP0000747_muscle_weakness0.99585049
78MP0005620_abnormal_muscle_contractility0.98795697
79MP0005165_increased_susceptibility_to0.98438429
80MP0003385_abnormal_body_wall0.98257732
81MP0009250_abnormal_appendicular_skeleto0.96595056
82MP0001533_abnormal_skeleton_physiology0.95966505
83MP0003300_gastrointestinal_ulcer0.95396558
84MP0000681_abnormal_thyroid_gland0.94952306
85MP0005332_abnormal_amino_acid0.94888484
86MP0000249_abnormal_blood_vessel0.94718645
87MP0005377_hearing/vestibular/ear_phenot0.94660478
88MP0003878_abnormal_ear_physiology0.94660478
89MP0003942_abnormal_urinary_system0.94580163
90MP0003690_abnormal_glial_cell0.93765653
91* MP0005023_abnormal_wound_healing0.93194331
92MP0005375_adipose_tissue_phenotype0.92658326
93MP0002972_abnormal_cardiac_muscle0.92550521
94MP0005369_muscle_phenotype0.92537136
95MP0000759_abnormal_skeletal_muscle0.91799054
96MP0002877_abnormal_melanocyte_morpholog0.91759604
97MP0008775_abnormal_heart_ventricle0.90385302
98MP0000013_abnormal_adipose_tissue0.90322177
99MP0002168_other_aberrant_phenotype0.89963405
100MP0002118_abnormal_lipid_homeostasis0.89744776
101MP0004145_abnormal_muscle_electrophysio0.88850376
102MP0000566_synostosis0.87771180
103MP0000003_abnormal_adipose_tissue0.86760824
104MP0002089_abnormal_postnatal_growth/wei0.86014576
105MP0002106_abnormal_muscle_physiology0.85749992
106MP0004883_abnormal_blood_vessel0.85184321
107MP0002925_abnormal_cardiovascular_devel0.85153578
108MP0002254_reproductive_system_inflammat0.85069302
109MP0009053_abnormal_anal_canal0.84800594
110MP0000163_abnormal_cartilage_morphology0.84726545
111MP0001243_abnormal_dermal_layer0.84657022
112MP0005388_respiratory_system_phenotype0.84621048
113MP0002133_abnormal_respiratory_system0.84621048
114MP0002249_abnormal_larynx_morphology0.84457432
115MP0000858_altered_metastatic_potential0.84345625
116MP0003724_increased_susceptibility_to0.84172946
117MP0005076_abnormal_cell_differentiation0.84024715
118MP0002060_abnormal_skin_morphology0.83370580
119MP0002896_abnormal_bone_mineralization0.82988070
120MP0001270_distended_abdomen0.80480488
121MP0000230_abnormal_systemic_arterial0.80418980
122MP0008260_abnormal_autophagy0.80175171
123MP0002971_abnormal_brown_adipose0.79395103
124MP0005058_abnormal_lysosome_morphology0.79371615
125MP0000266_abnormal_heart_morphology0.79285179
126MP0004484_altered_response_of0.78821441
127MP0005319_abnormal_enzyme/_coenzyme0.77513866
128MP0000762_abnormal_tongue_morphology0.77476676
129MP0003634_abnormal_glial_cell0.75950341
130MP0001299_abnormal_eye_distance/0.75210897
131MP0005164_abnormal_response_to0.75035618
132MP0004233_abnormal_muscle_weight0.73113290
133MP0005171_absent_coat_pigmentation0.68618640
134MP0002113_abnormal_skeleton_development0.68344055
135MP0002115_abnormal_skeleton_extremities0.68309548
136MP0003303_peritoneal_inflammation0.68013709
137MP0003448_altered_tumor_morphology0.67811658
138MP0001915_intracranial_hemorrhage0.66835759
139MP0002932_abnormal_joint_morphology0.66791504
140MP0000049_abnormal_middle_ear0.65835111

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.73446749
2Broad metatarsal (HP:0001783)4.59599765
3Premature rupture of membranes (HP:0001788)4.16256117
4Shallow orbits (HP:0000586)3.77425361
5Deep venous thrombosis (HP:0002625)3.39981502
6Muscle fiber splitting (HP:0003555)3.35752873
7Vertebral compression fractures (HP:0002953)3.23718613
8Hyporeflexia of lower limbs (HP:0002600)3.22400588
9Cerebral aneurysm (HP:0004944)3.18575515
10Spinal rigidity (HP:0003306)3.08757939
11Increased connective tissue (HP:0009025)3.07722324
12Type 1 muscle fiber predominance (HP:0003803)3.04350669
13Aortic dissection (HP:0002647)3.01453670
14Ankle contracture (HP:0006466)2.97917874
15Asymmetric septal hypertrophy (HP:0001670)2.89663770
16Obstructive sleep apnea (HP:0002870)2.88748665
17Aortic aneurysm (HP:0004942)2.83894927
18Polycythemia (HP:0001901)2.72235494
19Mesangial abnormality (HP:0001966)2.69867620
20Bronchomalacia (HP:0002780)2.68481368
21Nuclear cataract (HP:0100018)2.62978418
22Joint stiffness (HP:0001387)2.60790490
23Upper limb amyotrophy (HP:0009129)2.58613652
24Distal upper limb amyotrophy (HP:0007149)2.58613652
25Right ventricular cardiomyopathy (HP:0011663)2.55952519
26Exercise-induced myalgia (HP:0003738)2.53927895
27Difficulty running (HP:0009046)2.53600834
28Abnormality of complement system (HP:0005339)2.51807528
29Atrophic scars (HP:0001075)2.47831214
30Increased variability in muscle fiber diameter (HP:0003557)2.47063807
31Bladder diverticulum (HP:0000015)2.47028844
32Achilles tendon contracture (HP:0001771)2.45125467
33Distal lower limb muscle weakness (HP:0009053)2.42995467
34Mitral regurgitation (HP:0001653)2.39977643
35Esophageal varix (HP:0002040)2.39687859
36Dysostosis multiplex (HP:0000943)2.39438893
37Biconcave vertebral bodies (HP:0004586)2.39294081
38Vascular tortuosity (HP:0004948)2.38972946
39Osteolytic defects of the hand bones (HP:0009699)2.35846855
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.35846855
41Dilatation of the ascending aorta (HP:0005111)2.35571147
42Round ear (HP:0100830)2.34785849
43Cardiovascular calcification (HP:0011915)2.34558227
44Genu recurvatum (HP:0002816)2.32745361
45Abnormality of skeletal muscle fiber size (HP:0012084)2.30857513
46Abnormality of liposaccharide metabolism (HP:0010968)2.29947671
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.29947671
48Abnormality of glycolipid metabolism (HP:0010969)2.29947671
49Abnormality of the Achilles tendon (HP:0005109)2.29805885
50Hypoalphalipoproteinemia (HP:0003233)2.27807918
51Slender build (HP:0001533)2.26942249
52Urinary glycosaminoglycan excretion (HP:0003541)2.26799949
53Mucopolysacchariduria (HP:0008155)2.26799949
54Exercise-induced muscle cramps (HP:0003710)2.26056070
55Aneurysm (HP:0002617)2.23180709
56Pulmonary artery stenosis (HP:0004415)2.22901207
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22002196
58Abnormality of polysaccharide metabolism (HP:0011012)2.22002196
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22002196
60Arterial tortuosity (HP:0005116)2.20794315
61Hyperextensible skin (HP:0000974)2.18474535
62Hypoglycemic coma (HP:0001325)2.17479564
63Hyperacusis (HP:0010780)2.16546897
64Thin bony cortex (HP:0002753)2.16250478
65Complement deficiency (HP:0004431)2.15315841
66Peritonitis (HP:0002586)2.15248699
67Xanthomatosis (HP:0000991)2.14123770
68Turricephaly (HP:0000262)2.13277238
69Distal lower limb amyotrophy (HP:0008944)2.11345343
70Joint laxity (HP:0001388)2.10556464
71Myoglobinuria (HP:0002913)2.09976697
72Lymphangioma (HP:0100764)2.09909784
73Aortic regurgitation (HP:0001659)2.08362875
74Abnormality of the acetabulum (HP:0003170)2.06061083
75Hematochezia (HP:0002573)2.05382532
76Nonimmune hydrops fetalis (HP:0001790)2.04727918
77Vascular calcification (HP:0004934)2.04431272
78Lipoatrophy (HP:0100578)2.04195494
79Follicular hyperkeratosis (HP:0007502)2.04168843
80Broad face (HP:0000283)2.03371484
81Ventricular tachycardia (HP:0004756)2.01812050
82Hand muscle atrophy (HP:0009130)2.00382747
83Wormian bones (HP:0002645)2.00263768
84Mitral valve prolapse (HP:0001634)1.98827288
85Abnormality of the nasal mucosa (HP:0000433)1.98123332
86Short nail (HP:0001799)1.97667144
87Ectopia lentis (HP:0001083)1.97206985
88Coronal craniosynostosis (HP:0004440)1.97149008
89Mildly elevated creatine phosphokinase (HP:0008180)1.96711659
90Short hallux (HP:0010109)1.94563738
91Generalized amyotrophy (HP:0003700)1.94087796
92Blue sclerae (HP:0000592)1.94002541
93Visceral angiomatosis (HP:0100761)1.93636650
94Abnormality of dentin (HP:0010299)1.93233068
95Natal tooth (HP:0000695)1.92783255
96Myotonia (HP:0002486)1.92739455
97Wide anterior fontanel (HP:0000260)1.91928785
98Sudden death (HP:0001699)1.91889037
99Cervical subluxation (HP:0003308)1.91416814
100Muscle stiffness (HP:0003552)1.90606196
101Acanthosis nigricans (HP:0000956)1.90250197
102Elbow flexion contracture (HP:0002987)1.90212318
103Aplasia of the phalanges of the hand (HP:0009802)1.90198454
104Aplasia involving bones of the extremities (HP:0009825)1.90198454
105Aplasia involving bones of the upper limbs (HP:0009823)1.90198454
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.90041397
107Neonatal death (HP:0003811)1.89871012
108Enlarged penis (HP:0000040)1.89857196
109Atelectasis (HP:0100750)1.88636302
110EMG: myopathic abnormalities (HP:0003458)1.88144577
111Mitral stenosis (HP:0001718)1.87593936
112Axonal loss (HP:0003447)1.87518543
113Muscle fiber inclusion bodies (HP:0100299)1.86702511
114Bell-shaped thorax (HP:0001591)1.86112601
115Neurofibrillary tangles (HP:0002185)1.85515863
116Wrist flexion contracture (HP:0001239)1.85367656
117Humeroradial synostosis (HP:0003041)1.85102066
118Synostosis involving the elbow (HP:0003938)1.85102066
119Spontaneous hematomas (HP:0007420)1.84738320
120Systemic lupus erythematosus (HP:0002725)1.84395444
121Abnormality of the calf musculature (HP:0001430)1.83772851
122Disproportionate tall stature (HP:0001519)1.83389909
123Hemangiomatosis (HP:0007461)1.83027433
124Fragile skin (HP:0001030)1.82450821
125Hyperlipoproteinemia (HP:0010980)1.82349142
126Atrioventricular block (HP:0001678)1.82279100
127Stridor (HP:0010307)1.82184544
128Abnormality of fatty-acid metabolism (HP:0004359)1.82040297
129Tarsal synostosis (HP:0008368)1.81906734
130Hemorrhage of the eye (HP:0011885)1.80341582
131Ulnar bowing (HP:0003031)1.79011423
132Venous abnormality (HP:0002624)1.78691840
133Cerebral inclusion bodies (HP:0100314)1.78416123
134Hyperkalemia (HP:0002153)1.78047686
135Long toe (HP:0010511)1.77423028
136Atrial fibrillation (HP:0005110)1.77252845
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.77181990
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.76968580
139Hypoplastic left heart (HP:0004383)1.76887747
140Bowel diverticulosis (HP:0005222)1.76400896
141Bowing of the arm (HP:0006488)1.76094509
142Bowed forearm bones (HP:0003956)1.76094509
143Spondylolisthesis (HP:0003302)1.75112208
144Hypoventilation (HP:0002791)1.74970447
145Neonatal short-limb short stature (HP:0008921)1.74551457
146Coxa vara (HP:0002812)1.74362849
147Soft skin (HP:0000977)1.74257916
148Glomerulonephritis (HP:0000099)1.74134256
149Ulnar deviation of the wrist (HP:0003049)1.73448182
150Difficulty climbing stairs (HP:0003551)1.72966593
151Nasal polyposis (HP:0100582)1.71939952
152Abnormal delivery (HP:0001787)1.71761111
153Aortic valve stenosis (HP:0001650)1.71575287
154Camptodactyly of toe (HP:0001836)1.71531430
155Myocardial infarction (HP:0001658)1.69668403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.67292722
2TRIB34.03769907
3TTN3.22873160
4TGFBR23.01754773
5ERN12.63207168
6EPHB12.62537616
7RIPK12.57406900
8SIK12.39254934
9KDR2.22102035
10EPHB22.21723383
11MYLK1.93836646
12MAP2K31.93343638
13MET1.92168894
14PTK61.75807551
15BCKDK1.73383022
16PKN21.69152686
17LATS11.68694235
18CDC42BPA1.67332209
19PRPF4B1.67271414
20SMG11.66400390
21LMTK21.61710655
22DMPK1.58099485
23PTK2B1.52592913
24STK381.52544400
25IRAK31.52399008
26PDGFRA1.52134314
27MST1R1.51017695
28WNK41.50780675
29EEF2K1.50222392
30PHKG11.49612812
31PHKG21.49612812
32EPHA21.48671555
33PAK41.48638415
34DDR21.41631832
35FGFR21.41500113
36BMX1.37936186
37ARAF1.36190574
38PRKD31.33810846
39NME21.32140972
40MOS1.25278882
41LRRK21.25216564
42ILK1.24861105
43CAMK1D1.23850742
44TGFBR11.22513415
45RPS6KA21.20466781
46PTK21.18172035
47MAP3K71.17684045
48STK391.17206383
49MAP3K111.17180069
50LIMK11.14665061
51ICK1.12504175
52FGFR41.12382604
53ABL21.12012023
54CAMK1G1.11440901
55PDK21.10789150
56MAP3K131.06327066
57CDK121.02919699
58TAOK21.00852119
59OBSCN0.99848605
60PAK20.98493770
61INSRR0.97866836
62PDK40.97527754
63PDK30.97527754
64NEK90.93952896
65PIK3CA0.92122763
66PRKD10.91321962
67MAP2K20.87957999
68MUSK0.87010742
69MAP3K30.81986034
70FER0.81897837
71FGFR10.81440371
72PAK30.81073568
73RPS6KL10.79383516
74RPS6KC10.79383516
75MAP3K10.79318008
76MAPK120.78672382
77KSR20.78021658
78NTRK10.75993147
79ROCK10.75014836
80WNK10.74563159
81BRD40.74298818
82TBK10.73094668
83PRKCH0.71531314
84EPHA30.70633547
85MAPK150.70549305
86LATS20.69732068
87MARK20.68425097
88MAPKAPK30.68215546
89ROCK20.66852212
90RET0.66806662
91PIK3CG0.64845815
92MTOR0.64711626
93PDGFRB0.64218236
94PDPK10.63408301
95HIPK20.59202221
96MAPK70.58561957
97ZAP700.57288093
98PRKG20.56644537
99RPS6KA60.56428722
100PIM20.55242935
101PDK10.54788974
102TESK20.54694299
103BRAF0.53186158
104GSK3A0.52226134
105CAMK2G0.49798451
106TRPM70.48907558
107NLK0.48527056
108TESK10.45245552
109PRKD20.44930022
110TAOK10.44875351
111ERBB20.44263491
112MAPK40.44059875
113PRKAA20.42835813
114CAMK40.42045293
115KIT0.41958928
116STK30.41785175
117MAP3K80.41666824
118TYK20.40688511
119MAPK110.38730720
120MAPKAPK50.38546202
121SRC0.38391948
122PKN10.38320624
123PAK10.37976825
124SGK2230.37740839
125SGK4940.37740839
126FLT30.37585879
127PAK60.36435307
128STK100.36418635
129IGF1R0.35881659
130SGK30.35748432
131TYRO30.34258166
132MAP2K60.33623204
133CAMK10.33500901
134GRK70.33265473
135MAPKAPK20.33245361
136MAP2K40.33055848
137DYRK1B0.32887858
138MAP2K10.32079078
139DAPK30.31597860
140MAP3K60.31274810
141OXSR10.31172122

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.50644374
2Other glycan degradation_Homo sapiens_hsa005113.10851747
3Caffeine metabolism_Homo sapiens_hsa002322.80758752
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54709724
5Fatty acid degradation_Homo sapiens_hsa000712.50323462
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.36635300
7Fatty acid metabolism_Homo sapiens_hsa012122.24431750
8PPAR signaling pathway_Homo sapiens_hsa033202.08041404
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.06149814
10Complement and coagulation cascades_Homo sapiens_hsa046102.05814910
11Propanoate metabolism_Homo sapiens_hsa006402.03933576
12ECM-receptor interaction_Homo sapiens_hsa045121.92032769
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91525408
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73836205
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67154680
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59197709
17Fatty acid elongation_Homo sapiens_hsa000621.59158571
18Chemical carcinogenesis_Homo sapiens_hsa052041.53008279
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.51574811
20Tryptophan metabolism_Homo sapiens_hsa003801.51429198
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50751023
22Arginine biosynthesis_Homo sapiens_hsa002201.50531691
23Focal adhesion_Homo sapiens_hsa045101.49392470
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48779904
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46931258
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40904853
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.36788134
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32268381
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28458543
30Dilated cardiomyopathy_Homo sapiens_hsa054141.28389276
31Bile secretion_Homo sapiens_hsa049761.26024958
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22740699
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20813671
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20347472
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19819987
36Fatty acid biosynthesis_Homo sapiens_hsa000611.14838011
37VEGF signaling pathway_Homo sapiens_hsa043701.09844321
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09502210
39Amoebiasis_Homo sapiens_hsa051461.09266489
40Butanoate metabolism_Homo sapiens_hsa006501.09204290
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09086646
42Peroxisome_Homo sapiens_hsa041461.07916590
43Pyruvate metabolism_Homo sapiens_hsa006201.07742435
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07148251
45Galactose metabolism_Homo sapiens_hsa000521.04128713
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.01337015
47Proteoglycans in cancer_Homo sapiens_hsa052051.00880994
48Staphylococcus aureus infection_Homo sapiens_hsa051501.00778208
49Fructose and mannose metabolism_Homo sapiens_hsa000511.00646624
50Adherens junction_Homo sapiens_hsa045201.00626488
51beta-Alanine metabolism_Homo sapiens_hsa004100.99349510
52Histidine metabolism_Homo sapiens_hsa003400.97447909
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.97415243
54Starch and sucrose metabolism_Homo sapiens_hsa005000.97148974
55Protein digestion and absorption_Homo sapiens_hsa049740.96306035
56Endocytosis_Homo sapiens_hsa041440.96242284
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94107249
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.92313970
59Vitamin digestion and absorption_Homo sapiens_hsa049770.91266233
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91109256
61Chronic myeloid leukemia_Homo sapiens_hsa052200.90882641
62Insulin resistance_Homo sapiens_hsa049310.88890529
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88508542
64Acute myeloid leukemia_Homo sapiens_hsa052210.88231415
65Lysine degradation_Homo sapiens_hsa003100.88191124
66Tyrosine metabolism_Homo sapiens_hsa003500.87787529
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86979995
68Carbon metabolism_Homo sapiens_hsa012000.85244277
69Estrogen signaling pathway_Homo sapiens_hsa049150.84902350
70Basal cell carcinoma_Homo sapiens_hsa052170.84761326
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.83700880
72Ovarian steroidogenesis_Homo sapiens_hsa049130.82284492
73Malaria_Homo sapiens_hsa051440.81163284
74Retinol metabolism_Homo sapiens_hsa008300.80843970
75GnRH signaling pathway_Homo sapiens_hsa049120.79538830
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78240205
77Melanogenesis_Homo sapiens_hsa049160.78238621
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77410152
79Tight junction_Homo sapiens_hsa045300.77083403
80Pentose phosphate pathway_Homo sapiens_hsa000300.76207692
81Insulin signaling pathway_Homo sapiens_hsa049100.74230584
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.73368681
83Osteoclast differentiation_Homo sapiens_hsa043800.73334342
84Renin-angiotensin system_Homo sapiens_hsa046140.72972818
85Small cell lung cancer_Homo sapiens_hsa052220.72127632
86Sulfur metabolism_Homo sapiens_hsa009200.72045945
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72035664
88Hippo signaling pathway_Homo sapiens_hsa043900.68969857
89Arginine and proline metabolism_Homo sapiens_hsa003300.68078882
90TNF signaling pathway_Homo sapiens_hsa046680.66258550
91Gap junction_Homo sapiens_hsa045400.65917621
92Glutathione metabolism_Homo sapiens_hsa004800.65724156
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64987493
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64189530
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64131458
96Glioma_Homo sapiens_hsa052140.63320700
97Notch signaling pathway_Homo sapiens_hsa043300.63222277
98Steroid biosynthesis_Homo sapiens_hsa001000.62844495
99Biosynthesis of amino acids_Homo sapiens_hsa012300.62831924
100Vibrio cholerae infection_Homo sapiens_hsa051100.61932886
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60664995
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60513083
103Fat digestion and absorption_Homo sapiens_hsa049750.60345047
104Selenocompound metabolism_Homo sapiens_hsa004500.60192935
105Salmonella infection_Homo sapiens_hsa051320.59964823
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59491581
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58009899
108Glycerolipid metabolism_Homo sapiens_hsa005610.57188374
109Renin secretion_Homo sapiens_hsa049240.56165644
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55735528
111TGF-beta signaling pathway_Homo sapiens_hsa043500.55546597
112Rap1 signaling pathway_Homo sapiens_hsa040150.54402548
113Platelet activation_Homo sapiens_hsa046110.52541606
114Hedgehog signaling pathway_Homo sapiens_hsa043400.51987491
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51074409
116mTOR signaling pathway_Homo sapiens_hsa041500.50875693
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.50759709
118MicroRNAs in cancer_Homo sapiens_hsa052060.50495446
119Phenylalanine metabolism_Homo sapiens_hsa003600.50405543
120AMPK signaling pathway_Homo sapiens_hsa041520.49831452
121Choline metabolism in cancer_Homo sapiens_hsa052310.49365036
122Lysosome_Homo sapiens_hsa041420.48972497
123Phagosome_Homo sapiens_hsa041450.48899503
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48513188
125Bladder cancer_Homo sapiens_hsa052190.47982414
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47829959
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47569512
128Viral myocarditis_Homo sapiens_hsa054160.47159452
129ABC transporters_Homo sapiens_hsa020100.47128936
130MAPK signaling pathway_Homo sapiens_hsa040100.47053352
131Axon guidance_Homo sapiens_hsa043600.45483622
132Glucagon signaling pathway_Homo sapiens_hsa049220.45372752
133Gastric acid secretion_Homo sapiens_hsa049710.44798249
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.44724652
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.44653422
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42026298
137Toxoplasmosis_Homo sapiens_hsa051450.40427681
138Prion diseases_Homo sapiens_hsa050200.39613715
139Renal cell carcinoma_Homo sapiens_hsa052110.39206923
140Pertussis_Homo sapiens_hsa051330.38668991
141Pathways in cancer_Homo sapiens_hsa052000.38467840
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.37922954
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.37562270
144Sulfur relay system_Homo sapiens_hsa041220.34515384

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