SON

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.04280576
2mitotic sister chromatid cohesion (GO:0007064)4.67547499
3negative regulation of histone methylation (GO:0031061)4.61538645
4regulation of RNA export from nucleus (GO:0046831)4.61302829
5histone H3-K36 demethylation (GO:0070544)4.55135110
6monoubiquitinated protein deubiquitination (GO:0035520)4.40254627
7nuclear pore organization (GO:0006999)4.36854993
8regulation of histone H3-K27 methylation (GO:0061085)4.29147412
9pre-miRNA processing (GO:0031054)4.28921197
10histone H3-K4 trimethylation (GO:0080182)4.23533979
11negative regulation of DNA repair (GO:0045738)3.97440619
12axon ensheathment in central nervous system (GO:0032291)3.84622596
13central nervous system myelination (GO:0022010)3.84622596
14regulation of histone H3-K4 methylation (GO:0051569)3.76499553
15positive regulation by host of viral transcription (GO:0043923)3.55715481
16regulation of histone methylation (GO:0031060)3.51783979
17regulation of nucleobase-containing compound transport (GO:0032239)3.43376817
18pore complex assembly (GO:0046931)3.42207735
19histone H3-K9 methylation (GO:0051567)3.34339292
20regulation of DNA endoreduplication (GO:0032875)3.25031506
21cytoplasmic mRNA processing body assembly (GO:0033962)3.19933926
22histone H4-K16 acetylation (GO:0043984)3.19141893
23locomotory exploration behavior (GO:0035641)3.17750854
24V(D)J recombination (GO:0033151)3.17408683
25histone H3-K9 modification (GO:0061647)3.15709469
26presynaptic membrane assembly (GO:0097105)3.09773394
27translational termination (GO:0006415)3.09764884
28glucocorticoid receptor signaling pathway (GO:0042921)3.08055451
29maturation of SSU-rRNA (GO:0030490)3.05559056
30viral transcription (GO:0019083)3.05535902
31heterochromatin organization (GO:0070828)3.05513589
32histone deubiquitination (GO:0016578)3.05160921
33neuron cell-cell adhesion (GO:0007158)3.00552188
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.00173526
35regulation of translation, ncRNA-mediated (GO:0045974)3.00173526
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00173526
37positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.99122249
38positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.98371169
39activated T cell proliferation (GO:0050798)2.98164608
40ionotropic glutamate receptor signaling pathway (GO:0035235)2.98114227
41sister chromatid segregation (GO:0000819)2.97899931
42histone lysine demethylation (GO:0070076)2.97520334
43L-amino acid import (GO:0043092)2.97394323
44positive regulation of histone H3-K4 methylation (GO:0051571)2.97126685
45myelination (GO:0042552)2.91744032
46mitotic chromosome condensation (GO:0007076)2.89479268
47sister chromatid cohesion (GO:0007062)2.88500346
48layer formation in cerebral cortex (GO:0021819)2.86989670
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86925437
50ensheathment of neurons (GO:0007272)2.86702679
51axon ensheathment (GO:0008366)2.86702679
52neuron recognition (GO:0008038)2.86557812
53presynaptic membrane organization (GO:0097090)2.86282099
54negative T cell selection (GO:0043383)2.86157778
55kinetochore organization (GO:0051383)2.85986646
56transmission of nerve impulse (GO:0019226)2.85613183
57dendrite morphogenesis (GO:0048813)2.84826641
58histone demethylation (GO:0016577)2.83841655
59negative regulation of histone modification (GO:0031057)2.82993508
60DNA topological change (GO:0006265)2.82945639
61negative regulation of RNA splicing (GO:0033119)2.81458490
62interkinetic nuclear migration (GO:0022027)2.81304260
63regulation of histone H3-K9 methylation (GO:0051570)2.81204783
64positive regulation of gene expression, epigenetic (GO:0045815)2.80764061
65negative thymic T cell selection (GO:0045060)2.80478219
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79497441
67cerebellar Purkinje cell differentiation (GO:0021702)2.79438021
68histone methylation (GO:0016571)2.77144754
69glutamate receptor signaling pathway (GO:0007215)2.76330946
70positive regulation of DNA-templated transcription, initiation (GO:2000144)2.75056475
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74941615
72protein targeting to Golgi (GO:0000042)2.74736266
73dendritic spine morphogenesis (GO:0060997)2.73361909
74axonal fasciculation (GO:0007413)2.71826771
75phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.70933265
76positive regulation of histone methylation (GO:0031062)2.70503935
77retrograde transport, vesicle recycling within Golgi (GO:0000301)2.70459555
78negative regulation of chromatin modification (GO:1903309)2.70336339
79asymmetric protein localization (GO:0008105)2.69578367
80peptidyl-lysine trimethylation (GO:0018023)2.69161782
81DNA synthesis involved in DNA repair (GO:0000731)2.68992520
82ribosomal small subunit biogenesis (GO:0042274)2.68195857
83establishment of protein localization to Golgi (GO:0072600)2.68026980
84mitotic sister chromatid segregation (GO:0000070)2.67130575
85spliceosomal complex assembly (GO:0000245)2.66008940
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65210288
87alternative mRNA splicing, via spliceosome (GO:0000380)2.64773168
88positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.61986484
89regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.61986484
90DNA duplex unwinding (GO:0032508)2.61527035
91nucleus localization (GO:0051647)2.60691096
92eye photoreceptor cell differentiation (GO:0001754)2.60488856
93photoreceptor cell differentiation (GO:0046530)2.60488856
94establishment of nucleus localization (GO:0040023)2.59837560
95positive regulation of mRNA catabolic process (GO:0061014)2.59329461
96cellular potassium ion homeostasis (GO:0030007)2.59150470
97negative regulation of neurotransmitter secretion (GO:0046929)2.58490926
98peptidyl-tyrosine autophosphorylation (GO:0038083)2.57914819
99negative regulation of neurotransmitter transport (GO:0051589)2.57552150
100DNA geometric change (GO:0032392)2.57476335
101stress granule assembly (GO:0034063)2.56493819
102regulation of gene silencing by RNA (GO:0060966)2.56253850
103regulation of posttranscriptional gene silencing (GO:0060147)2.56253850
104regulation of gene silencing by miRNA (GO:0060964)2.56253850
105nerve growth factor signaling pathway (GO:0038180)2.56190659
106histone H3-K4 methylation (GO:0051568)2.56074572
107regulation of protein polyubiquitination (GO:1902914)2.55309099
108embryonic camera-type eye morphogenesis (GO:0048596)2.54389789
109regulation of NFAT protein import into nucleus (GO:0051532)2.53934688
110corticosteroid receptor signaling pathway (GO:0031958)2.53551620
111prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.53426286
112negative regulation of mRNA processing (GO:0050686)2.53146016
113histone H4 acetylation (GO:0043967)2.52059156
114otic vesicle formation (GO:0030916)2.52024605
115cerebellar granule cell differentiation (GO:0021707)2.51355358
116histone H3-K9 demethylation (GO:0033169)2.50752184
117amino acid import (GO:0043090)2.49886186
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47688747
119dosage compensation (GO:0007549)2.47682785
120regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.47408383
121positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.47408383
122regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46089919
123radial glial cell differentiation (GO:0060019)2.45463479
124negative regulation of cell killing (GO:0031342)2.45195357
125negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45195357
126positive regulation of RNA splicing (GO:0033120)2.45126620
127genitalia morphogenesis (GO:0035112)2.44198605
128tongue development (GO:0043586)2.41959218
129gamma-aminobutyric acid signaling pathway (GO:0007214)2.40965510
130positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.40124539
131branching involved in prostate gland morphogenesis (GO:0060442)2.40006507
132mRNA transport (GO:0051028)2.39270105
133potassium ion import (GO:0010107)2.39092478
134protein demethylation (GO:0006482)2.38796122
135protein dealkylation (GO:0008214)2.38796122
136modulation by host of symbiont transcription (GO:0052472)2.38507745
137mating behavior (GO:0007617)2.35139132
138mRNA splice site selection (GO:0006376)2.34901025
139myelination in peripheral nervous system (GO:0022011)2.34790512
140peripheral nervous system axon ensheathment (GO:0032292)2.34790512
141positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.33577922
142neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.33541154
143cytoskeletal anchoring at plasma membrane (GO:0007016)2.32645636
144sodium ion export (GO:0071436)2.31851129
145neuronal ion channel clustering (GO:0045161)2.30861879
146cell differentiation in hindbrain (GO:0021533)2.30577377
147negative regulation of synaptic transmission, GABAergic (GO:0032229)2.30410697
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.28165472
149lateral sprouting from an epithelium (GO:0060601)2.27362626
150regulation of dendritic spine morphogenesis (GO:0061001)2.25243604
151Golgi to endosome transport (GO:0006895)2.24466556
152negative regulation of axon extension (GO:0030517)2.23730223
153neuronal stem cell maintenance (GO:0097150)2.23590034
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.22428874
155regulation of mRNA 3-end processing (GO:0031440)2.21755717
156oligodendrocyte differentiation (GO:0048709)2.20388035
157suckling behavior (GO:0001967)2.18868672
158L-serine transport (GO:0015825)2.17878009
159regulation of ARF protein signal transduction (GO:0032012)2.17758102
160cerebral cortex radially oriented cell migration (GO:0021799)2.16432606
161histone lysine methylation (GO:0034968)2.13720879
162limb bud formation (GO:0060174)2.13603782
163neuron remodeling (GO:0016322)2.12867441
164positive regulation of mRNA processing (GO:0050685)2.12489773
165synaptic transmission, glutamatergic (GO:0035249)2.11997138
166peptidyl-lysine methylation (GO:0018022)2.10928588
167positive regulation of synapse assembly (GO:0051965)2.09472741
168innervation (GO:0060384)2.08590445
169vocalization behavior (GO:0071625)2.08452892
170exploration behavior (GO:0035640)2.07944904
171membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.07634495
172negative regulation of protein localization to cell surface (GO:2000009)2.07610892
173regulation of respiratory system process (GO:0044065)2.06289758
174protein localization to synapse (GO:0035418)2.05126273
175apical protein localization (GO:0045176)2.04706513
176negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.03604974
177negative regulation of cytosolic calcium ion concentration (GO:0051481)2.03518195
178synapse organization (GO:0050808)2.02878453
179regulation of glutamate receptor signaling pathway (GO:1900449)2.02776436
180regulation of beta-amyloid formation (GO:1902003)2.02720198
181central nervous system projection neuron axonogenesis (GO:0021952)2.02693204
182regulation of axon extension involved in axon guidance (GO:0048841)2.02352169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.24264429
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.49731869
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71006326
4EZH2_22144423_ChIP-Seq_EOC_Human3.69520712
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.59694540
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.27971761
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.10312006
8GBX2_23144817_ChIP-Seq_PC3_Human2.90323090
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34721639
10* MYC_22102868_ChIP-Seq_BL_Human2.31686706
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30850538
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29515682
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28365802
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.28113751
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22033579
16* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20865489
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19905175
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16906136
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14871983
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13628207
21DROSHA_22980978_ChIP-Seq_HELA_Human2.07263732
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04096319
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04096319
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98832962
25AR_21572438_ChIP-Seq_LNCaP_Human1.96647412
26CIITA_25753668_ChIP-Seq_RAJI_Human1.93949728
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.92554727
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91466988
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90428660
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90375911
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.89509769
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88611580
33GATA1_22025678_ChIP-Seq_K562_Human1.88486463
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87306087
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.82885212
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82381436
37TAF15_26573619_Chip-Seq_HEK293_Human1.81876669
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77421065
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.77120037
40TP53_16413492_ChIP-PET_HCT116_Human1.75029316
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74302580
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74140186
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71652010
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60763212
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60712851
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59206399
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59071505
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.58129068
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56727240
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.56331411
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55986312
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55751659
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52959717
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52959717
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52959717
56FUS_26573619_Chip-Seq_HEK293_Human1.52489923
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.51428071
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51041242
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48937114
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48275899
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46839390
62SMAD4_21799915_ChIP-Seq_A2780_Human1.46489767
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.46309727
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.46155653
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.45259809
66AHR_22903824_ChIP-Seq_MCF-7_Human1.43642615
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43537820
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43256748
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43199123
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40170324
71STAT3_23295773_ChIP-Seq_U87_Human1.39277286
72AR_21909140_ChIP-Seq_LNCAP_Human1.38408604
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37249804
74P300_19829295_ChIP-Seq_ESCs_Human1.36850189
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.36706607
76* EST1_17652178_ChIP-ChIP_JURKAT_Human1.36282682
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36092658
78ZNF274_21170338_ChIP-Seq_K562_Hela1.35711243
79KDM5A_27292631_Chip-Seq_BREAST_Human1.35087966
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33830691
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33830691
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33828302
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32750306
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32115745
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30758457
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30489130
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29265951
88CHD1_26751641_Chip-Seq_LNCaP_Human1.28448960
89* ELK1_19687146_ChIP-ChIP_HELA_Human1.27989078
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27010773
91* TCF4_23295773_ChIP-Seq_U87_Human1.26917635
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26094922
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25162021
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24951257
95REST_21632747_ChIP-Seq_MESCs_Mouse1.24770464
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24155529
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.23971382
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.23354585
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22831493
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22763508
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18428508
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.18082286
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17895410
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16831021
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14457566
106AR_19668381_ChIP-Seq_PC3_Human1.13726378
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13709549
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13528044
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13266744
110ISL1_27105846_Chip-Seq_CPCs_Mouse1.12747306
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12511553
112ER_23166858_ChIP-Seq_MCF-7_Human1.12386903
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.12188480
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11367822
115BCAT_22108803_ChIP-Seq_LS180_Human1.10774572
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10601895
117MYB_26560356_Chip-Seq_TH1_Human1.10206498
118EWS_26573619_Chip-Seq_HEK293_Human1.10021429
119TTF2_22483619_ChIP-Seq_HELA_Human1.09491038
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07707311
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07627206
122MYC_18555785_ChIP-Seq_MESCs_Mouse1.07508154
123CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07080845
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06808207
125RUNX2_22187159_ChIP-Seq_PCA_Human1.06670850
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06540310
127* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05944625
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.05525256
129MYB_26560356_Chip-Seq_TH2_Human1.05127785
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05056983
131RING1B_27294783_Chip-Seq_ESCs_Mouse1.04749821
132RUNX_20019798_ChIP-Seq_JUKART_Human1.04580573
133EP300_21415370_ChIP-Seq_HL-1_Mouse1.03225210
134* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02978955
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02791058
136SOX9_26525672_Chip-Seq_HEART_Mouse1.02705109
137AR_25329375_ChIP-Seq_VCAP_Human1.01830045
138NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01217207
139ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01201815
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00423711
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99820861
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.99454763
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98867520
144HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98782354
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98499260
146TP53_18474530_ChIP-ChIP_U2OS_Human0.98189292
147FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95530179
148VDR_23849224_ChIP-Seq_CD4+_Human0.94445436
149TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93232616
150SCL_19346495_ChIP-Seq_HPC-7_Human0.93206582
151TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93169993
152MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92973898
153* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92917062
154POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92626087
155SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84358727
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83784400
157TCF7_22412390_ChIP-Seq_EML_Mouse0.82106408
158MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81563355
159RXR_22108803_ChIP-Seq_LS180_Human0.80915173
160FOXP3_21729870_ChIP-Seq_TREG_Human0.80526258
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80294189
162FLI1_27457419_Chip-Seq_LIVER_Mouse0.80171953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.17641061
2MP0000569_abnormal_digit_pigmentation3.29569689
3MP0003880_abnormal_central_pattern3.19986277
4MP0004859_abnormal_synaptic_plasticity2.90068307
5MP0000566_synostosis2.82847171
6MP0005423_abnormal_somatic_nervous2.58940873
7MP0002396_abnormal_hematopoietic_system2.56796524
8MP0010094_abnormal_chromosome_stability2.56656086
9MP0003890_abnormal_embryonic-extraembry2.49358936
10MP0006292_abnormal_olfactory_placode2.32470753
11MP0000778_abnormal_nervous_system2.29581698
12MP0003635_abnormal_synaptic_transmissio2.28661160
13MP0004270_analgesia2.27457065
14MP0004885_abnormal_endolymph2.26549914
15MP0002166_altered_tumor_susceptibility2.23184705
16MP0009379_abnormal_foot_pigmentation2.22731382
17MP0003787_abnormal_imprinting2.19004133
18MP0001486_abnormal_startle_reflex2.18146831
19MP0003111_abnormal_nucleus_morphology2.15335176
20MP0000920_abnormal_myelination2.10182054
21MP0003077_abnormal_cell_cycle2.02046532
22MP0004742_abnormal_vestibular_system1.96943516
23MP0003763_abnormal_thymus_physiology1.95342249
24MP0006072_abnormal_retinal_apoptosis1.92285076
25MP0009745_abnormal_behavioral_response1.91577813
26MP0005551_abnormal_eye_electrophysiolog1.91376186
27MP0005409_darkened_coat_color1.91232407
28MP0002064_seizures1.85302001
29MP0008877_abnormal_DNA_methylation1.83892367
30MP0005076_abnormal_cell_differentiation1.79530207
31MP0001440_abnormal_grooming_behavior1.78502515
32MP0009046_muscle_twitch1.78190348
33MP0002272_abnormal_nervous_system1.76181164
34MP0004808_abnormal_hematopoietic_stem1.69573962
35MP0008995_early_reproductive_senescence1.69554573
36MP0002572_abnormal_emotion/affect_behav1.67108782
37MP0002063_abnormal_learning/memory/cond1.65039604
38MP0009780_abnormal_chondrocyte_physiolo1.64906567
39MP0001299_abnormal_eye_distance/1.64652443
40MP0005171_absent_coat_pigmentation1.64004073
41MP0008569_lethality_at_weaning1.60417248
42MP0003690_abnormal_glial_cell1.59871249
43MP0001485_abnormal_pinna_reflex1.57491690
44MP0002067_abnormal_sensory_capabilities1.51540796
45MP0003045_fibrosis1.51174076
46MP0000350_abnormal_cell_proliferation1.50949754
47MP0002006_tumorigenesis1.48262363
48MP0002697_abnormal_eye_size1.46981375
49MP0001286_abnormal_eye_development1.46885592
50MP0008058_abnormal_DNA_repair1.46210856
51MP0003634_abnormal_glial_cell1.45205498
52MP0004957_abnormal_blastocyst_morpholog1.45036909
53MP0004381_abnormal_hair_follicle1.43361566
54MP0010678_abnormal_skin_adnexa1.43064926
55MP0003693_abnormal_embryo_hatching1.42650178
56MP0003984_embryonic_growth_retardation1.41399771
57MP0002088_abnormal_embryonic_growth/wei1.40192150
58MP0009703_decreased_birth_body1.39149842
59MP0000383_abnormal_hair_follicle1.37834665
60MP0002184_abnormal_innervation1.37267116
61MP0004145_abnormal_muscle_electrophysio1.36618952
62MP0005253_abnormal_eye_physiology1.35479751
63MP0002084_abnormal_developmental_patter1.34528067
64MP0003950_abnormal_plasma_membrane1.32363213
65MP0002882_abnormal_neuron_morphology1.32022793
66MP0003315_abnormal_perineum_morphology1.28720184
67MP0000955_abnormal_spinal_cord1.28045370
68MP0002928_abnormal_bile_duct1.27752363
69MP0002085_abnormal_embryonic_tissue1.27596879
70MP0005623_abnormal_meninges_morphology1.26355119
71MP0000703_abnormal_thymus_morphology1.25547540
72MP0003943_abnormal_hepatobiliary_system1.25407499
73MP0005380_embryogenesis_phenotype1.25018790
74MP0001672_abnormal_embryogenesis/_devel1.25018790
75MP0001697_abnormal_embryo_size1.23499031
76MP0001873_stomach_inflammation1.22362050
77MP0010307_abnormal_tumor_latency1.22273800
78MP0004197_abnormal_fetal_growth/weight/1.21675589
79MP0001501_abnormal_sleep_pattern1.21563259
80MP0008961_abnormal_basal_metabolism1.16816179
81MP0001502_abnormal_circadian_rhythm1.16735170
82MP0000462_abnormal_digestive_system1.16080893
83MP0002249_abnormal_larynx_morphology1.14511926
84MP0003632_abnormal_nervous_system1.14491021
85MP0000631_abnormal_neuroendocrine_gland1.14450385
86MP0002229_neurodegeneration1.14202064
87MP0005187_abnormal_penis_morphology1.13895597
88MP0002152_abnormal_brain_morphology1.13851849
89MP0004924_abnormal_behavior1.13563508
90MP0005386_behavior/neurological_phenoty1.13563508
91MP0002734_abnormal_mechanical_nocicepti1.13559240
92MP0009672_abnormal_birth_weight1.13330067
93MP0002557_abnormal_social/conspecific_i1.12443828
94MP0010030_abnormal_orbit_morphology1.11964285
95MP0004134_abnormal_chest_morphology1.11891542
96MP0003121_genomic_imprinting1.09758952
97MP0005310_abnormal_salivary_gland1.09629675
98MP0002009_preneoplasia1.08774188
99MP0005195_abnormal_posterior_eye1.07824359
100MP0008007_abnormal_cellular_replicative1.07061634
101MP0003300_gastrointestinal_ulcer1.06556651
102MP0001968_abnormal_touch/_nociception1.02903571
103MP0001293_anophthalmia0.99851063
104MP0003755_abnormal_palate_morphology0.99512008
105MP0002092_abnormal_eye_morphology0.99013308
106MP0000428_abnormal_craniofacial_morphol0.98807636
107MP0003122_maternal_imprinting0.98707829
108MP0003938_abnormal_ear_development0.98652098
109MP0002752_abnormal_somatic_nervous0.98127988
110MP0002086_abnormal_extraembryonic_tissu0.97472392
111MP0003115_abnormal_respiratory_system0.97222670
112MP0003861_abnormal_nervous_system0.96755152
113MP0001851_eye_inflammation0.95316702
114MP0003283_abnormal_digestive_organ0.94441967
115MP0010352_gastrointestinal_tract_polyps0.93052710
116MP0001963_abnormal_hearing_physiology0.92805728
117MP0003183_abnormal_peptide_metabolism0.92201431
118MP0000733_abnormal_muscle_development0.92101114
119MP0003633_abnormal_nervous_system0.90960113
120MP0002095_abnormal_skin_pigmentation0.90883745
121MP0003631_nervous_system_phenotype0.90515386
122MP0002075_abnormal_coat/hair_pigmentati0.89399732
123MP0002938_white_spotting0.89393428
124MP0001730_embryonic_growth_arrest0.89368574
125MP0003937_abnormal_limbs/digits/tail_de0.89250925
126MP0002066_abnormal_motor_capabilities/c0.88021331
127MP0005075_abnormal_melanosome_morpholog0.87956002
128MP0003385_abnormal_body_wall0.87528428
129MP0001188_hyperpigmentation0.87384734
130MP0005391_vision/eye_phenotype0.84868488
131MP0005645_abnormal_hypothalamus_physiol0.84843891
132MP0003091_abnormal_cell_migration0.84373356
133MP0003935_abnormal_craniofacial_develop0.83322012
134MP0004185_abnormal_adipocyte_glucose0.81756677
135MP0000371_diluted_coat_color0.81307294
136MP0002925_abnormal_cardiovascular_devel0.81020689
137MP0001943_abnormal_respiration0.80406044
138MP0002080_prenatal_lethality0.80223874
139MP0002111_abnormal_tail_morphology0.80025532
140MP0005174_abnormal_tail_pigmentation0.79746685
141MP0003329_amyloid_beta_deposits0.79638360
142MP0003942_abnormal_urinary_system0.78480962
143MP0001186_pigmentation_phenotype0.78260924
144MP0003136_yellow_coat_color0.78014924
145MP0001661_extended_life_span0.77895011
146MP0003567_abnormal_fetal_cardiomyocyte0.77569318
147MP0002109_abnormal_limb_morphology0.76651016
148MP0002108_abnormal_muscle_morphology0.76371154
149MP0002081_perinatal_lethality0.76309971
150MP0000003_abnormal_adipose_tissue0.76282138
151MP0001879_abnormal_lymphatic_vessel0.76043286
152MP0000537_abnormal_urethra_morphology0.75535221
153MP0009384_cardiac_valve_regurgitation0.75188572
154MP0000026_abnormal_inner_ear0.75042541
155MP0002233_abnormal_nose_morphology0.74449365
156MP0001919_abnormal_reproductive_system0.73722225
157MP0002398_abnormal_bone_marrow0.73327199
158MP0004811_abnormal_neuron_physiology0.72564391
159MP0001970_abnormal_pain_threshold0.71852440
160MP0002733_abnormal_thermal_nociception0.71116908
161MP0000647_abnormal_sebaceous_gland0.70058564
162MP0005503_abnormal_tendon_morphology0.69088500
163MP0002234_abnormal_pharynx_morphology0.68148879
164MP0000579_abnormal_nail_morphology0.68131797
165MP0004085_abnormal_heartbeat0.67893311
166MP0003936_abnormal_reproductive_system0.67813691
167MP0001346_abnormal_lacrimal_gland0.67496982
168MP0002736_abnormal_nociception_after0.66462226
169MP0000432_abnormal_head_morphology0.66384234
170MP0002116_abnormal_craniofacial_bone0.65455498

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)3.25986765
2Oligodactyly (hands) (HP:0001180)3.00902060
311 pairs of ribs (HP:0000878)2.89776290
4Abnormal hair whorl (HP:0010721)2.85042364
5Abnormality of the fingertips (HP:0001211)2.79336726
6Chromsome breakage (HP:0040012)2.75707971
7Acute myeloid leukemia (HP:0004808)2.74837277
8Volvulus (HP:0002580)2.65214393
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60126528
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.57174460
11Degeneration of the lateral corticospinal tracts (HP:0002314)2.57174460
12Abnormal number of incisors (HP:0011064)2.56260871
13Anteriorly placed anus (HP:0001545)2.53374689
14Abnormality of the parietal bone (HP:0002696)2.52189145
15Cerebral inclusion bodies (HP:0100314)2.50701131
16Partial duplication of thumb phalanx (HP:0009944)2.45509612
17Missing ribs (HP:0000921)2.45043570
18Low anterior hairline (HP:0000294)2.44869230
19Reticulocytopenia (HP:0001896)2.44058068
20Widely spaced teeth (HP:0000687)2.39206501
21Aqueductal stenosis (HP:0002410)2.39141693
22Midline defect of the nose (HP:0004122)2.38825076
23Hemiparesis (HP:0001269)2.37872586
24Abnormality of the distal phalanx of the thumb (HP:0009617)2.37622757
25Acute lymphatic leukemia (HP:0006721)2.37259994
26Abnormality of incisor morphology (HP:0011063)2.36862068
27Abnormality of the incisor (HP:0000676)2.36161553
28Septate vagina (HP:0001153)2.34121991
29Neurofibrillary tangles (HP:0002185)2.32095056
30Broad-based gait (HP:0002136)2.28363800
31Chin dimple (HP:0010751)2.28145878
32Abnormality of chromosome stability (HP:0003220)2.28139893
33Drooling (HP:0002307)2.26390597
34Excessive salivation (HP:0003781)2.26390597
35Truncal ataxia (HP:0002078)2.25596844
36Focal seizures (HP:0007359)2.25144493
37Supranuclear gaze palsy (HP:0000605)2.24040554
38Ectopic kidney (HP:0000086)2.23708152
39Septo-optic dysplasia (HP:0100842)2.22230040
40Broad thumb (HP:0011304)2.17888525
41Narrow palate (HP:0000189)2.16676196
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15994779
43Short 4th metacarpal (HP:0010044)2.15994779
44Sandal gap (HP:0001852)2.15319687
45Partial duplication of the phalanx of hand (HP:0009999)2.14753712
46Heterotopia (HP:0002282)2.13992911
47Urethral obstruction (HP:0000796)2.13816224
48Homocystinuria (HP:0002156)2.09353117
49Abnormality of homocysteine metabolism (HP:0010919)2.09353117
50Overlapping toe (HP:0001845)2.08622615
51Termporal pattern (HP:0011008)2.08244264
52Insidious onset (HP:0003587)2.08244264
53Hemiplegia (HP:0002301)2.07751873
54Diplopia (HP:0000651)2.06571252
55Abnormality of binocular vision (HP:0011514)2.06571252
56Short middle phalanx of finger (HP:0005819)2.05335366
57Hypoplastic labia majora (HP:0000059)2.04164644
58Scanning speech (HP:0002168)2.03043070
59Abnormality of the corticospinal tract (HP:0002492)2.02472342
60Alacrima (HP:0000522)2.01581711
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01182371
62Cupped ear (HP:0000378)2.01151343
63Truncal obesity (HP:0001956)2.01051396
64Progressive cerebellar ataxia (HP:0002073)2.00773660
65Action tremor (HP:0002345)2.00667181
66Trigonocephaly (HP:0000243)2.00626121
67Abnormality of the lacrimal duct (HP:0011481)2.00281749
68Mixed hearing impairment (HP:0000410)1.99026134
69Hypoplasia of the maxilla (HP:0000327)1.98925654
70Exotropia (HP:0000577)1.98568843
712-3 toe syndactyly (HP:0004691)1.98280867
72High anterior hairline (HP:0009890)1.98280310
73Nasolacrimal duct obstruction (HP:0000579)1.98037939
74Hepatoblastoma (HP:0002884)1.97967872
75Duplication of thumb phalanx (HP:0009942)1.97364076
76Obsessive-compulsive behavior (HP:0000722)1.96359867
77Nephroblastoma (Wilms tumor) (HP:0002667)1.93849429
78Gaze-evoked nystagmus (HP:0000640)1.93418969
79Oligodactyly (HP:0012165)1.93327207
80Anal stenosis (HP:0002025)1.92241415
81Aplasia involving bones of the upper limbs (HP:0009823)1.91378271
82Aplasia of the phalanges of the hand (HP:0009802)1.91378271
83Aplasia involving bones of the extremities (HP:0009825)1.91378271
84Broad ribs (HP:0000885)1.91199737
85Abnormality of the parathyroid morphology (HP:0011766)1.90762620
86Abnormality of the nasolacrimal system (HP:0000614)1.89978009
87Synophrys (HP:0000664)1.89965893
88Deep philtrum (HP:0002002)1.89253363
89Thick eyebrow (HP:0000574)1.89027661
90Dysmetria (HP:0001310)1.88249322
91Prominent nose (HP:0000448)1.88180896
92Decreased lacrimation (HP:0000633)1.87933446
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.87324547
94Hypoplastic nipples (HP:0002557)1.86963301
95Buphthalmos (HP:0000557)1.85986820
96Abnormality of the labia majora (HP:0012881)1.85343264
97Supernumerary ribs (HP:0005815)1.85164809
98Neoplasm of the oral cavity (HP:0100649)1.85156882
99Abnormality of cells of the erythroid lineage (HP:0012130)1.84972019
100Sensory axonal neuropathy (HP:0003390)1.84809497
101Atonic seizures (HP:0010819)1.84575090
102Increased nuchal translucency (HP:0010880)1.84086150
103Thickened helices (HP:0000391)1.82694752
104Neonatal hypoglycemia (HP:0001998)1.82442158
105Absent frontal sinuses (HP:0002688)1.80905048
106Persistence of primary teeth (HP:0006335)1.79739901
107Abnormality of the nasal septum (HP:0000419)1.79263452
108Aplasia cutis congenita (HP:0001057)1.79098205
109Clubbing of toes (HP:0100760)1.77743078
110Peripheral hypomyelination (HP:0007182)1.77617448
111Abnormality of the ileum (HP:0001549)1.76815310
112Impulsivity (HP:0100710)1.76806758
113Absent speech (HP:0001344)1.76022275
114Rib fusion (HP:0000902)1.75880878
115Broad phalanges of the hand (HP:0009768)1.75691749
116Spastic gait (HP:0002064)1.75099238
117Broad finger (HP:0001500)1.74412507
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.73915876
119Abnormality of the septum pellucidum (HP:0007375)1.73834281
120Overriding aorta (HP:0002623)1.72856216
121Meckel diverticulum (HP:0002245)1.72579696
122Embryonal renal neoplasm (HP:0011794)1.72539956
123Dislocated radial head (HP:0003083)1.72494234
124Abnormality of the radial head (HP:0003995)1.71237982
125Focal motor seizures (HP:0011153)1.71230347
126Tracheomalacia (HP:0002779)1.71061675
127Abnormality of salivation (HP:0100755)1.70774715
128Abnormal number of erythroid precursors (HP:0012131)1.69947924
129Intention tremor (HP:0002080)1.69927872
130Gastrointestinal atresia (HP:0002589)1.69377275
131Vertebral arch anomaly (HP:0008438)1.68683940
132Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.68602550
133Tapered finger (HP:0001182)1.68597643
134Dysdiadochokinesis (HP:0002075)1.67753913
135Onion bulb formation (HP:0003383)1.67378942
136Highly arched eyebrow (HP:0002553)1.67368235
137Arterial tortuosity (HP:0005116)1.66438182
138Myelodysplasia (HP:0002863)1.66386308
139Cafe-au-lait spot (HP:0000957)1.65710266
140Synostosis involving the elbow (HP:0003938)1.65062055
141Humeroradial synostosis (HP:0003041)1.65062055
142Abnormality of the antihelix (HP:0009738)1.64727776
143Megalencephaly (HP:0001355)1.64445247
144Diastasis recti (HP:0001540)1.64294653
145Epileptic encephalopathy (HP:0200134)1.63550931
146Broad face (HP:0000283)1.62203977
147Sporadic (HP:0003745)1.61805894
148Wide nose (HP:0000445)1.61657303
149Laryngomalacia (HP:0001601)1.60920794
150Gastroesophageal reflux (HP:0002020)1.60805573
151Abnormality of chromosome segregation (HP:0002916)1.60579513
152Mask-like facies (HP:0000298)1.59880411
153Abnormal foot bone ossification (HP:0010675)1.59503616
154Hypoplastic ischia (HP:0003175)1.58725810
155Large earlobe (HP:0009748)1.58451422
156Bronchomalacia (HP:0002780)1.58151562
157Hypoplasia of the iris (HP:0007676)1.57330933
158Insomnia (HP:0100785)1.57032455
159Protruding tongue (HP:0010808)1.56936664
160Broad palm (HP:0001169)1.56931974
161Lip pit (HP:0100267)1.56542484
162Open mouth (HP:0000194)1.55686774
163Thyroiditis (HP:0100646)1.55512617
164Limited elbow extension (HP:0001377)1.54782921
165Supernumerary bones of the axial skeleton (HP:0009144)1.54575860
166Hypoplastic pelvis (HP:0008839)1.54332652
167Long eyelashes (HP:0000527)1.54044030
168Long nose (HP:0003189)1.52959047
169Genetic anticipation (HP:0003743)1.52827147
170Tented upper lip vermilion (HP:0010804)1.52750785
171Arnold-Chiari malformation (HP:0002308)1.51773281
172Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.51357999
173Neoplasm of the heart (HP:0100544)1.51273950
174Abnormality of the 4th metacarpal (HP:0010012)1.51140517
175Impaired smooth pursuit (HP:0007772)1.51073694
176Febrile seizures (HP:0002373)1.49847933
177Blue irides (HP:0000635)1.48682942
178Esophageal atresia (HP:0002032)1.48501331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.59552840
2CAMK1G3.24066702
3BRD42.57538355
4SIK22.41583244
5CDC72.41410668
6NLK2.27532905
7FGFR22.25298728
8STK392.17170930
9CDK122.15954877
10TNIK2.08168560
11CAMK1D2.00993208
12WEE11.94885430
13WNK11.85079999
14EEF2K1.78323896
15PASK1.75613554
16NTRK31.74630148
17NTRK21.73324096
18EPHB11.63471830
19MKNK11.58760364
20FGR1.58239110
21TAF11.56734101
22EPHA41.52674647
23PDGFRB1.52543522
24ICK1.49627261
25AKT31.49062645
26RIPK41.48799277
27TYRO31.47275500
28BRSK21.43523790
29MARK21.40723821
30FES1.37791404
31PKN11.35745526
32MAP3K41.27823868
33CSNK1A1L1.25916167
34LATS11.24821911
35INSRR1.23035247
36UHMK11.19771114
37SMG11.19007792
38FGFR41.18692282
39TRIB31.16942221
40CDK41.16856881
41CDC42BPA1.15872116
42DMPK1.14719279
43PDGFRA1.09254803
44MAP3K141.08754509
45ATR1.08384987
46MAPK151.07981211
47MAPK131.04351244
48OXSR11.03906821
49HIPK21.01710794
50PTK61.00517029
51PRKCH0.98575671
52MARK10.97226846
53CHEK10.97008628
54CHUK0.96455061
55NUAK10.95550054
56RIPK10.95200474
57CDK90.93993296
58PRKD20.92863525
59STK110.92055142
60CHEK20.91296234
61MAP3K130.91075851
62SGK10.90614523
63ROCK20.90137809
64ATM0.87610994
65MAP3K70.87162608
66CDK50.83114796
67PRKCQ0.82520611
68PAK60.81301136
69CDK30.81015112
70ITK0.80787045
71DYRK1A0.79015107
72PAK30.78872401
73CSNK1G20.78229442
74MAP4K10.78081506
75WNK40.77366274
76MAP3K100.76277568
77FYN0.76003735
78TTN0.74350503
79EPHA30.71005627
80FGFR10.70846008
81PTK2B0.70678521
82NEK60.69662695
83RET0.68421663
84CDK20.68176064
85SGK4940.68029883
86SGK2230.68029883
87MELK0.67829226
88PRKD10.67672318
89SIK10.67435086
90NTRK10.67181049
91TTK0.66606613
92YES10.64900730
93TRPM70.64859414
94FGFR30.64087782
95STK30.64085998
96HCK0.63986614
97TEC0.63419029
98TAOK30.63399030
99CSNK1D0.63297973
100CDK60.63189340
101CAMK2B0.63096475
102MAPK100.63076637
103* CDK10.62447563
104TNK20.62307097
105SRPK10.62267705
106STK40.61765610
107CDK70.60521664
108MTOR0.60151399
109CLK10.59664483
110CSNK1G10.59638000
111IRAK10.59410940
112INSR0.57638924
113PRKDC0.57278061
114AURKB0.55577238
115LCK0.55421742
116PRKAA20.54794989
117CASK0.53663244
118MKNK20.53317116
119MAP3K20.53160943
120KSR10.52825920
121CSNK1G30.52764369
122PRPF4B0.51957398
123AKT10.51751370
124NEK20.51289374
125RPS6KA30.50763718
126DYRK30.50501048
127* GSK3B0.50281669
128PIM10.49472173
129BTK0.49200013
130SGK30.48975313
131TGFBR10.48695668
132SGK20.47966367
133PLK40.46932860
134CSNK1E0.46748924
135CAMK2A0.46737671
136CSK0.46371178
137CAMK2D0.45659602
138PAK20.45077724
139PRKCE0.45048714
140MAPK80.44773387
141JAK10.44308924
142MAP3K90.44245436
143ERBB20.42971980
144* MAPK140.42738078
145SRC0.42591768
146MARK30.42404290
147RPS6KB20.39630746
148MAPK10.36443519
149BMPR1B0.36040794
150NME10.35119610

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030402.65549082
2mRNA surveillance pathway_Homo sapiens_hsa030152.19072508
3Non-homologous end-joining_Homo sapiens_hsa034502.15633510
4Nicotine addiction_Homo sapiens_hsa050332.14305416
5Ribosome_Homo sapiens_hsa030102.11964412
6Glutamatergic synapse_Homo sapiens_hsa047241.98648460
7Homologous recombination_Homo sapiens_hsa034401.93301268
8Cell cycle_Homo sapiens_hsa041101.89560644
9Fanconi anemia pathway_Homo sapiens_hsa034601.80243562
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77707325
11RNA transport_Homo sapiens_hsa030131.72512981
12Long-term potentiation_Homo sapiens_hsa047201.72042920
13Morphine addiction_Homo sapiens_hsa050321.71320817
14Circadian entrainment_Homo sapiens_hsa047131.69692532
15Renin secretion_Homo sapiens_hsa049241.67950551
16Salivary secretion_Homo sapiens_hsa049701.64987777
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.64681960
18DNA replication_Homo sapiens_hsa030301.63893362
19Phototransduction_Homo sapiens_hsa047441.62009395
20Axon guidance_Homo sapiens_hsa043601.60140778
21GABAergic synapse_Homo sapiens_hsa047271.58212284
22Dorso-ventral axis formation_Homo sapiens_hsa043201.55667036
23Long-term depression_Homo sapiens_hsa047301.49768310
24Gastric acid secretion_Homo sapiens_hsa049711.47360258
25Acute myeloid leukemia_Homo sapiens_hsa052211.45894650
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43268384
27RNA degradation_Homo sapiens_hsa030181.42556320
28Mismatch repair_Homo sapiens_hsa034301.42290432
29Thyroid cancer_Homo sapiens_hsa052161.40120905
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39739379
31Type II diabetes mellitus_Homo sapiens_hsa049301.39483103
32Taste transduction_Homo sapiens_hsa047421.36098264
33Endometrial cancer_Homo sapiens_hsa052131.35843857
34Amphetamine addiction_Homo sapiens_hsa050311.33341936
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32699687
36Cholinergic synapse_Homo sapiens_hsa047251.31796375
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30883771
38Insulin secretion_Homo sapiens_hsa049111.29634424
39Dopaminergic synapse_Homo sapiens_hsa047281.29285211
40Serotonergic synapse_Homo sapiens_hsa047261.29046356
41Oxytocin signaling pathway_Homo sapiens_hsa049211.27231249
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25976319
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24952622
44Small cell lung cancer_Homo sapiens_hsa052221.20342437
45RNA polymerase_Homo sapiens_hsa030201.18300490
46cAMP signaling pathway_Homo sapiens_hsa040241.18010220
47GnRH signaling pathway_Homo sapiens_hsa049121.17045366
48Cocaine addiction_Homo sapiens_hsa050301.16755205
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16571688
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.15783611
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15258863
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14943513
53Choline metabolism in cancer_Homo sapiens_hsa052311.14706931
54Estrogen signaling pathway_Homo sapiens_hsa049151.14106299
55Hepatitis B_Homo sapiens_hsa051611.14029056
56Calcium signaling pathway_Homo sapiens_hsa040201.13532242
57FoxO signaling pathway_Homo sapiens_hsa040681.12779653
58Prolactin signaling pathway_Homo sapiens_hsa049171.12428095
59TGF-beta signaling pathway_Homo sapiens_hsa043501.11233767
60Renal cell carcinoma_Homo sapiens_hsa052111.10423961
61Nucleotide excision repair_Homo sapiens_hsa034201.10342201
62B cell receptor signaling pathway_Homo sapiens_hsa046621.10286531
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10243975
64Pancreatic secretion_Homo sapiens_hsa049721.06020738
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.05867940
66T cell receptor signaling pathway_Homo sapiens_hsa046601.04129403
67Olfactory transduction_Homo sapiens_hsa047401.01765433
68Dilated cardiomyopathy_Homo sapiens_hsa054141.00172825
69Measles_Homo sapiens_hsa051620.99855948
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99830303
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99719407
72Gap junction_Homo sapiens_hsa045400.98528295
73Glioma_Homo sapiens_hsa052140.97740639
74Basal transcription factors_Homo sapiens_hsa030220.97385580
75HTLV-I infection_Homo sapiens_hsa051660.96744035
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95803915
77Lysine degradation_Homo sapiens_hsa003100.95735967
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95674393
79Melanogenesis_Homo sapiens_hsa049160.95560875
80Epstein-Barr virus infection_Homo sapiens_hsa051690.93328012
81ErbB signaling pathway_Homo sapiens_hsa040120.93155331
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92933197
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91948210
84MAPK signaling pathway_Homo sapiens_hsa040100.91402444
85One carbon pool by folate_Homo sapiens_hsa006700.88126969
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88072562
87Wnt signaling pathway_Homo sapiens_hsa043100.86627536
88Inositol phosphate metabolism_Homo sapiens_hsa005620.85872941
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85095265
90Protein export_Homo sapiens_hsa030600.84933203
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84792371
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.83361638
93ECM-receptor interaction_Homo sapiens_hsa045120.83036853
94Hippo signaling pathway_Homo sapiens_hsa043900.81136707
95Herpes simplex infection_Homo sapiens_hsa051680.80758829
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80395404
97Basal cell carcinoma_Homo sapiens_hsa052170.79741376
98Focal adhesion_Homo sapiens_hsa045100.78559258
99Platelet activation_Homo sapiens_hsa046110.77783938
100Notch signaling pathway_Homo sapiens_hsa043300.77779539
101Hedgehog signaling pathway_Homo sapiens_hsa043400.77590183
102Rap1 signaling pathway_Homo sapiens_hsa040150.77459244
103MicroRNAs in cancer_Homo sapiens_hsa052060.77068355
104Ras signaling pathway_Homo sapiens_hsa040140.75955737
105Thyroid hormone synthesis_Homo sapiens_hsa049180.75569076
106Chemokine signaling pathway_Homo sapiens_hsa040620.75525459
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.75254094
108Prostate cancer_Homo sapiens_hsa052150.74737001
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74268375
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.74215347
111Melanoma_Homo sapiens_hsa052180.72588531
112Ether lipid metabolism_Homo sapiens_hsa005650.72319323
113Proteoglycans in cancer_Homo sapiens_hsa052050.72191757
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71799410
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71258056
116Viral carcinogenesis_Homo sapiens_hsa052030.71056053
117Influenza A_Homo sapiens_hsa051640.70430419
118Primary immunodeficiency_Homo sapiens_hsa053400.69728390
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68970743
120VEGF signaling pathway_Homo sapiens_hsa043700.68912768
121Chronic myeloid leukemia_Homo sapiens_hsa052200.64947005
122Oocyte meiosis_Homo sapiens_hsa041140.64525491
123mTOR signaling pathway_Homo sapiens_hsa041500.64285341
124Ovarian steroidogenesis_Homo sapiens_hsa049130.63914321
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63730369
126Osteoclast differentiation_Homo sapiens_hsa043800.63310045
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62533648
128p53 signaling pathway_Homo sapiens_hsa041150.61975801
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61933924
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60469302
131Non-small cell lung cancer_Homo sapiens_hsa052230.60468221
132Colorectal cancer_Homo sapiens_hsa052100.58536019
133Adherens junction_Homo sapiens_hsa045200.58232375
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57748649
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57543811
136Fatty acid biosynthesis_Homo sapiens_hsa000610.56956595
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.56297202
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55517684
139Circadian rhythm_Homo sapiens_hsa047100.55512932
140Vitamin digestion and absorption_Homo sapiens_hsa049770.55397988
141Selenocompound metabolism_Homo sapiens_hsa004500.54537376
142Pancreatic cancer_Homo sapiens_hsa052120.53515761
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.53342583
144Pathways in cancer_Homo sapiens_hsa052000.53025316
145Tight junction_Homo sapiens_hsa045300.52859484
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52822698
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.48113063
148Toxoplasmosis_Homo sapiens_hsa051450.46959211
149Autoimmune thyroid disease_Homo sapiens_hsa053200.46705816
150Hepatitis C_Homo sapiens_hsa051600.44358337
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40095795
152Huntingtons disease_Homo sapiens_hsa050160.39851578

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