SOHLH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)8.63461904
2meiotic cell cycle (GO:0051321)6.74534521
3regulation of female gonad development (GO:2000194)6.50519977
4nuclear pore organization (GO:0006999)5.91324546
5piRNA metabolic process (GO:0034587)5.86477455
6nuclear pore complex assembly (GO:0051292)5.74277465
7regulation of posttranscriptional gene silencing (GO:0060147)5.60787762
8regulation of gene silencing by miRNA (GO:0060964)5.60787762
9regulation of gene silencing by RNA (GO:0060966)5.60787762
10positive regulation of histone H3-K4 methylation (GO:0051571)5.60468400
11regulation of meiosis I (GO:0060631)5.32719296
12retinal cone cell development (GO:0046549)4.99878595
13oocyte development (GO:0048599)4.95844815
14centriole replication (GO:0007099)4.94005124
15synaptonemal complex assembly (GO:0007130)4.87444629
16DNA methylation involved in gamete generation (GO:0043046)4.85411633
17DNA replication checkpoint (GO:0000076)4.73754816
18positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.70879197
19positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.70879197
20positive regulation of mitotic sister chromatid separation (GO:1901970)4.70879197
21regulation of acrosome reaction (GO:0060046)4.68851310
22CENP-A containing nucleosome assembly (GO:0034080)4.67034035
23heterochromatin organization (GO:0070828)4.58715553
24DNA replication-dependent nucleosome assembly (GO:0006335)4.57713788
25DNA replication-dependent nucleosome organization (GO:0034723)4.57713788
26DNA replication initiation (GO:0006270)4.56361958
27DNA unwinding involved in DNA replication (GO:0006268)4.49496968
28* female gamete generation (GO:0007292)4.38889759
29synaptonemal complex organization (GO:0070193)4.32987949
30mitotic nuclear envelope disassembly (GO:0007077)4.32354854
31pore complex assembly (GO:0046931)4.30658339
32DNA strand elongation involved in DNA replication (GO:0006271)4.22574358
33multicellular organism reproduction (GO:0032504)4.21978844
34glycine transport (GO:0015816)4.17387257
35chromosome organization involved in meiosis (GO:0070192)4.17233775
36meiotic nuclear division (GO:0007126)4.11568940
37somatic diversification of immune receptors via somatic mutation (GO:0002566)4.06801323
38somatic hypermutation of immunoglobulin genes (GO:0016446)4.06801323
39membrane disassembly (GO:0030397)4.06413861
40nuclear envelope disassembly (GO:0051081)4.06413861
41meiotic chromosome segregation (GO:0045132)4.02509721
42regulation of cell maturation (GO:1903429)4.02096967
43protein localization to kinetochore (GO:0034501)4.00635936
44mitotic metaphase plate congression (GO:0007080)3.99548002
45histone H4-K12 acetylation (GO:0043983)3.97059931
46DNA strand elongation (GO:0022616)3.96961228
47protein localization to chromosome (GO:0034502)3.94937926
48regulation of helicase activity (GO:0051095)3.94561332
49mitotic chromosome condensation (GO:0007076)3.94106755
50attachment of spindle microtubules to kinetochore (GO:0008608)3.93694778
51translesion synthesis (GO:0019985)3.92496517
52reciprocal DNA recombination (GO:0035825)3.86250377
53reciprocal meiotic recombination (GO:0007131)3.86250377
54regulation of steroid hormone secretion (GO:2000831)3.83028218
55positive regulation of histone methylation (GO:0031062)3.82301791
56sister chromatid cohesion (GO:0007062)3.81806894
57regulation of meiosis (GO:0040020)3.79279350
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76793568
59formation of translation preinitiation complex (GO:0001731)3.76116453
60IMP biosynthetic process (GO:0006188)3.74934537
61telomere maintenance via semi-conservative replication (GO:0032201)3.74919732
62histone exchange (GO:0043486)3.74147924
63negative regulation of reproductive process (GO:2000242)3.70306404
64pre-miRNA processing (GO:0031054)3.70060619
65negative regulation of meiosis (GO:0045835)3.70005021
66regulation of histone H3-K9 methylation (GO:0051570)3.69503584
67centriole assembly (GO:0098534)3.69338783
68metaphase plate congression (GO:0051310)3.68888505
69DNA replication-independent nucleosome assembly (GO:0006336)3.67450681
70DNA replication-independent nucleosome organization (GO:0034724)3.67450681
71mitotic sister chromatid segregation (GO:0000070)3.66627229
72nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.65455545
73regulation of spindle organization (GO:0090224)3.65248941
74regulation of histone H3-K4 methylation (GO:0051569)3.58106363
75DNA duplex unwinding (GO:0032508)3.57951176
76kinetochore organization (GO:0051383)3.57713787
77DNA geometric change (GO:0032392)3.57690085
78male meiosis (GO:0007140)3.57689243
79meiosis I (GO:0007127)3.56316069
80gene silencing by RNA (GO:0031047)3.55207573
81nucleobase biosynthetic process (GO:0046112)3.54882487
82protein K6-linked ubiquitination (GO:0085020)3.52950355
83meiotic cell cycle process (GO:1903046)3.50247707
84positive regulation of gastrulation (GO:2000543)3.49033162
85gene silencing (GO:0016458)3.48973495
86primitive streak formation (GO:0090009)3.48969862
87negative regulation of chromosome segregation (GO:0051985)3.47109015
88chromatin remodeling at centromere (GO:0031055)3.46148028
89kinetochore assembly (GO:0051382)3.40232670
90telomere maintenance via recombination (GO:0000722)3.37881995
91regulation of double-strand break repair via homologous recombination (GO:0010569)3.37724579
92chromatin assembly (GO:0031497)3.37530946
93ribosome biogenesis (GO:0042254)3.37492458
94DNA methylation (GO:0006306)3.36948124
95DNA alkylation (GO:0006305)3.36948124
96DNA damage induced protein phosphorylation (GO:0006975)3.36190542
97regulation of histone methylation (GO:0031060)3.36084489
98protein localization to chromosome, centromeric region (GO:0071459)3.35079803
99negative regulation of mitotic sister chromatid separation (GO:2000816)3.33093397
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.33093397
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33093397
102negative regulation of sister chromatid segregation (GO:0033046)3.33093397
103spindle assembly checkpoint (GO:0071173)3.33033088
104mitotic spindle assembly checkpoint (GO:0007094)3.32829968
105mitotic recombination (GO:0006312)3.32529154
106regulation of spindle checkpoint (GO:0090231)3.31758810
107mitotic spindle checkpoint (GO:0071174)3.30831537
108positive regulation of chromosome segregation (GO:0051984)3.30764304
109negative regulation of histone methylation (GO:0031061)3.30686413
110regulation of chromosome segregation (GO:0051983)3.29977240
111regulation of meiotic cell cycle (GO:0051445)3.27780970
112binding of sperm to zona pellucida (GO:0007339)3.27322052
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27029037
114histone arginine methylation (GO:0034969)3.25917330
115spindle checkpoint (GO:0031577)3.24211419
116telomere maintenance via telomere lengthening (GO:0010833)3.24092672
117male meiosis I (GO:0007141)3.23512763
118IMP metabolic process (GO:0046040)3.22009867
119ribosome assembly (GO:0042255)3.20942119
120sister chromatid segregation (GO:0000819)3.20750428
121purine nucleobase biosynthetic process (GO:0009113)3.20555986
122regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18694277
123postreplication repair (GO:0006301)3.17981631
124regulation of nuclear cell cycle DNA replication (GO:0033262)3.17600597
125nucleotide-excision repair, DNA gap filling (GO:0006297)3.16454325
126folic acid-containing compound biosynthetic process (GO:0009396)3.16108019
127regulation of mitotic sister chromatid separation (GO:0010965)3.15325633
128regulation of mitotic sister chromatid segregation (GO:0033047)3.15325633
129regulation of sister chromatid segregation (GO:0033045)3.15325633
130determination of adult lifespan (GO:0008340)3.14984325
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14335432
132regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13747495
133regulation of gene silencing (GO:0060968)3.13657941
134maturation of SSU-rRNA (GO:0030490)3.12956490
135synapsis (GO:0007129)3.12786654
136establishment of chromosome localization (GO:0051303)3.10416698
137chromatin assembly or disassembly (GO:0006333)3.10179372
138regulation of telomere maintenance via telomerase (GO:0032210)3.09393039
139histone H4-K5 acetylation (GO:0043981)3.08780337
140histone H4-K8 acetylation (GO:0043982)3.08780337
141regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07522546
142regulation of mitotic spindle checkpoint (GO:1903504)3.07522546
143DNA conformation change (GO:0071103)3.06898690
144oocyte maturation (GO:0001556)3.04827093
145chromosome segregation (GO:0007059)3.02581626
146labyrinthine layer development (GO:0060711)2.99636359
147mitotic G2/M transition checkpoint (GO:0044818)2.98739434
148nucleus organization (GO:0006997)2.98262326
149fertilization (GO:0009566)2.97488164
150resolution of meiotic recombination intermediates (GO:0000712)2.97275378
151protein kinase C signaling (GO:0070528)2.93163386
152centrosome duplication (GO:0051298)2.93026145
153phosphorelay signal transduction system (GO:0000160)2.90030950
154somite rostral/caudal axis specification (GO:0032525)2.86723656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.00146636
2EZH2_22144423_ChIP-Seq_EOC_Human8.40144283
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.24033555
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.99696841
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.53805228
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.53805228
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.53805228
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49115550
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.29756125
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02255267
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97045941
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.93928842
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.80420977
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62644302
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61917423
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.54782816
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53618405
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50813671
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.49301091
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.37141591
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37035055
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32566524
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30438998
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26820206
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.23776348
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.23085984
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16159180
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14200190
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.12213194
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09784138
31STAT3_1855785_ChIP-Seq_MESCs_Mouse2.09289024
32MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00437978
33AR_21909140_ChIP-Seq_LNCAP_Human1.97560787
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.93596787
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.92779443
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92658270
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.90010932
38XRN2_22483619_ChIP-Seq_HELA_Human1.89386538
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89262794
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88460316
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.87708376
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.85012268
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.83468985
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82034458
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80251291
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78372790
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77917096
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.77412363
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75010561
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.72123164
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70811212
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69104217
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67722412
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66934396
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63675533
56EWS_26573619_Chip-Seq_HEK293_Human1.63620549
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56424120
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.54732271
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53604135
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52877510
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.52192429
62GBX2_23144817_ChIP-Seq_PC3_Human1.50807024
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50086948
64* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49807426
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48445455
66DCP1A_22483619_ChIP-Seq_HELA_Human1.48070441
67IRF1_19129219_ChIP-ChIP_H3396_Human1.46705211
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44886415
69VDR_23849224_ChIP-Seq_CD4+_Human1.44355407
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40927863
71TTF2_22483619_ChIP-Seq_HELA_Human1.39312571
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39302766
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.38885818
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37025895
75GABP_19822575_ChIP-Seq_HepG2_Human1.35673301
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35504677
77FUS_26573619_Chip-Seq_HEK293_Human1.35258495
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35062497
79NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.34781879
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34036548
81KDM5A_27292631_Chip-Seq_BREAST_Human1.33484180
82FOXP3_21729870_ChIP-Seq_TREG_Human1.30565392
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29807300
84VDR_22108803_ChIP-Seq_LS180_Human1.26014613
85POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25602763
86ELK1_19687146_ChIP-ChIP_HELA_Human1.24417724
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23041964
88NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22882699
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22639322
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.22476216
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19242765
92CBP_20019798_ChIP-Seq_JUKART_Human1.19218273
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19218273
94CIITA_25753668_ChIP-Seq_RAJI_Human1.18010835
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17755205
96ZNF274_21170338_ChIP-Seq_K562_Hela1.16992308
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15923212
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15914559
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12530870
100NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10122863
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09676357
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.09275147
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08418085
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08132553
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07922465
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07365642
107NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05227842
108POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04957312
109RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04884201
110TFEB_21752829_ChIP-Seq_HELA_Human1.04012077
111P300_19829295_ChIP-Seq_ESCs_Human1.03869755
112MYC_22102868_ChIP-Seq_BL_Human1.03428176
113HTT_18923047_ChIP-ChIP_STHdh_Human1.03276631
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01978423
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00799641
116* TCF4_23295773_ChIP-Seq_U87_Human1.00303320
117* MYC_18940864_ChIP-ChIP_HL60_Human0.99723898
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98882544
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98314017
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97098612
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96285313
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94549293
123FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92867653
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90579679
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90163990
126STAT3_23295773_ChIP-Seq_U87_Human0.90135594
127TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89758436
128KAP1_27257070_Chip-Seq_ESCs_Mouse0.88467621
129TP53_22573176_ChIP-Seq_HFKS_Human0.88360757
130PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87643211
131NANOG_16518401_ChIP-PET_MESCs_Mouse0.86960397
132SALL4_22934838_ChIP-ChIP_CD34+_Human0.86911055
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86372932
134LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86267831
135SMAD4_21799915_ChIP-Seq_A2780_Human0.86113042
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85364759
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83885489
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82968357
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82897845
140TAF15_26573619_Chip-Seq_HEK293_Human0.82742560
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.80356499
142RUNX2_22187159_ChIP-Seq_PCA_Human0.80099131
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78922919
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78603064
145PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77993926
146IGF1R_20145208_ChIP-Seq_DFB_Human0.76856668
147HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75702948
148ER_23166858_ChIP-Seq_MCF-7_Human0.74127124
149RNF2_27304074_Chip-Seq_NSC_Mouse0.73932220
150* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.73508139
151CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73217135
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.72341733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.83965837
2MP0010094_abnormal_chromosome_stability4.73674919
3MP0008057_abnormal_DNA_replication4.46354168
4MP0004957_abnormal_blastocyst_morpholog4.27710344
5MP0003111_abnormal_nucleus_morphology4.17580936
6MP0003693_abnormal_embryo_hatching3.90025083
7MP0008789_abnormal_olfactory_epithelium3.66002090
8MP0008058_abnormal_DNA_repair3.61910317
9MP0003077_abnormal_cell_cycle3.54637114
10MP0005394_taste/olfaction_phenotype3.11797807
11MP0005499_abnormal_olfactory_system3.11797807
12MP0003123_paternal_imprinting3.05880535
13MP0010352_gastrointestinal_tract_polyps2.86311692
14MP0005395_other_phenotype2.82738629
15MP0002210_abnormal_sex_determination2.56486062
16MP0001730_embryonic_growth_arrest2.55203525
17MP0003786_premature_aging2.51362644
18MP0008932_abnormal_embryonic_tissue2.40738946
19MP0000350_abnormal_cell_proliferation2.35878348
20MP0008007_abnormal_cellular_replicative2.29080522
21MP0002653_abnormal_ependyma_morphology2.16202295
22MP0002234_abnormal_pharynx_morphology2.13411529
23* MP0001145_abnormal_male_reproductive2.13139776
24* MP0001929_abnormal_gametogenesis2.09668358
25MP0003890_abnormal_embryonic-extraembry2.05519238
26MP0003806_abnormal_nucleotide_metabolis2.01150025
27MP0005380_embryogenesis_phenotype1.98902905
28MP0001672_abnormal_embryogenesis/_devel1.98902905
29MP0010307_abnormal_tumor_latency1.97456439
30MP0008995_early_reproductive_senescence1.92184925
31MP0002084_abnormal_developmental_patter1.91018963
32MP0003121_genomic_imprinting1.89538677
33MP0002085_abnormal_embryonic_tissue1.88918489
34MP0004197_abnormal_fetal_growth/weight/1.87099788
35* MP0000653_abnormal_sex_gland1.84955261
36MP0001697_abnormal_embryo_size1.81994675
37MP0005076_abnormal_cell_differentiation1.74382316
38MP0003950_abnormal_plasma_membrane1.72680735
39MP0004133_heterotaxia1.70219732
40MP0003984_embryonic_growth_retardation1.69464062
41MP0002139_abnormal_hepatobiliary_system1.67559239
42MP0002088_abnormal_embryonic_growth/wei1.66008568
43MP0005360_urolithiasis1.65354811
44MP0002086_abnormal_extraembryonic_tissu1.65085464
45MP0003119_abnormal_digestive_system1.63013805
46MP0003718_maternal_effect1.62105174
47MP0002138_abnormal_hepatobiliary_system1.59093112
48MP0005410_abnormal_fertilization1.58611919
49MP0002080_prenatal_lethality1.56681238
50* MP0003698_abnormal_male_reproductive1.51514826
51MP0001293_anophthalmia1.39451928
52MP0000566_synostosis1.32212380
53MP0003705_abnormal_hypodermis_morpholog1.31511161
54MP0005647_abnormal_sex_gland1.29972727
55MP0003315_abnormal_perineum_morphology1.29861952
56MP0003941_abnormal_skin_development1.28659917
57MP0001984_abnormal_olfaction1.28538781
58MP0003567_abnormal_fetal_cardiomyocyte1.27466932
59MP0000313_abnormal_cell_death1.25805688
60MP0002233_abnormal_nose_morphology1.23499141
61MP0003879_abnormal_hair_cell1.20394788
62MP0003183_abnormal_peptide_metabolism1.19809273
63MP0000631_abnormal_neuroendocrine_gland1.15294042
64* MP0001119_abnormal_female_reproductive1.14981750
65MP0010678_abnormal_skin_adnexa1.13370062
66MP0001849_ear_inflammation1.12410033
67MP0009697_abnormal_copulation1.10898105
68MP0002019_abnormal_tumor_incidence1.09615145
69MP0000537_abnormal_urethra_morphology1.09394333
70MP0002160_abnormal_reproductive_system1.07063713
71* MP0002161_abnormal_fertility/fecundity1.06682188
72MP0003283_abnormal_digestive_organ1.06546734
73MP0010030_abnormal_orbit_morphology1.05518466
74MP0003937_abnormal_limbs/digits/tail_de1.03804659
75MP0000427_abnormal_hair_cycle1.00493858
76MP0003787_abnormal_imprinting1.00024528
77MP0000762_abnormal_tongue_morphology0.99136130
78MP0004264_abnormal_extraembryonic_tissu0.98032814
79MP0003936_abnormal_reproductive_system0.97281104
80MP0006292_abnormal_olfactory_placode0.95872591
81MP0003136_yellow_coat_color0.93850846
82MP0005266_abnormal_metabolism0.93293576
83MP0003566_abnormal_cell_adhesion0.92977397
84MP0000490_abnormal_crypts_of0.91765524
85MP0002102_abnormal_ear_morphology0.91334397
86* MP0003699_abnormal_female_reproductive0.86271413
87MP0003252_abnormal_bile_duct0.85498924
88MP0005023_abnormal_wound_healing0.85118953
89MP0009703_decreased_birth_body0.84577387
90MP0005646_abnormal_pituitary_gland0.83754058
91MP0003861_abnormal_nervous_system0.82357599
92MP0009672_abnormal_birth_weight0.81309624
93MP0002396_abnormal_hematopoietic_system0.80894234
94MP0002111_abnormal_tail_morphology0.80750523
95MP0001915_intracranial_hemorrhage0.80479033
96MP0005384_cellular_phenotype0.80382784
97MP0000049_abnormal_middle_ear0.80180101
98MP0005551_abnormal_eye_electrophysiolog0.79081200
99MP0004233_abnormal_muscle_weight0.78943084
100MP0005389_reproductive_system_phenotype0.77997935
101MP0005623_abnormal_meninges_morphology0.77279145
102MP0005621_abnormal_cell_physiology0.76835751
103MP0005501_abnormal_skin_physiology0.74255813
104MP0000516_abnormal_urinary_system0.73476537
105MP0005367_renal/urinary_system_phenotyp0.73476537
106MP0010234_abnormal_vibrissa_follicle0.73299683
107MP0002269_muscular_atrophy0.72604515
108MP0006276_abnormal_autonomic_nervous0.71088008
109MP0002092_abnormal_eye_morphology0.70557557
110MP0000432_abnormal_head_morphology0.69113300
111MP0000358_abnormal_cell_content/0.68887462
112MP0000678_abnormal_parathyroid_gland0.68149545
113MP0004142_abnormal_muscle_tone0.66280238
114MP0003935_abnormal_craniofacial_develop0.63684909
115MP0000383_abnormal_hair_follicle0.63656947
116MP0002697_abnormal_eye_size0.62602169
117MP0004185_abnormal_adipocyte_glucose0.62024574
118MP0005085_abnormal_gallbladder_physiolo0.60945679
119MP0002796_impaired_skin_barrier0.60875489
120MP0001286_abnormal_eye_development0.60263543
121MP0009053_abnormal_anal_canal0.59525261
122MP0001986_abnormal_taste_sensitivity0.59099347
123MP0010368_abnormal_lymphatic_system0.59039163
124MP0003115_abnormal_respiratory_system0.58798540
125MP0003221_abnormal_cardiomyocyte_apopto0.58542175
126MP0001324_abnormal_eye_pigmentation0.58430601
127MP0002075_abnormal_coat/hair_pigmentati0.57290648
128MP0004084_abnormal_cardiac_muscle0.56871419
129MP0002249_abnormal_larynx_morphology0.55555577
130MP0003755_abnormal_palate_morphology0.55283139
131MP0002272_abnormal_nervous_system0.55178220
132MP0000428_abnormal_craniofacial_morphol0.54618615
133MP0004808_abnormal_hematopoietic_stem0.53986871
134MP0005377_hearing/vestibular/ear_phenot0.53148497
135MP0003878_abnormal_ear_physiology0.53148497
136MP0002925_abnormal_cardiovascular_devel0.53005935
137MP0000477_abnormal_intestine_morphology0.52158926
138MP0008775_abnormal_heart_ventricle0.51845120
139MP0005174_abnormal_tail_pigmentation0.49509445
140MP0003656_abnormal_erythrocyte_physiolo0.48176965
141MP0002163_abnormal_gland_morphology0.47941825
142MP0002751_abnormal_autonomic_nervous0.47392601
143MP0009379_abnormal_foot_pigmentation0.44581641
144MP0003186_abnormal_redox_activity0.44320877
145MP0000647_abnormal_sebaceous_gland0.42344095

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.18910677
2Abnormality of the labia minora (HP:0012880)4.52092012
3Cholecystitis (HP:0001082)4.42121228
4Abnormal gallbladder physiology (HP:0012438)4.42121228
5Chromsome breakage (HP:0040012)4.40421295
6Osteomalacia (HP:0002749)4.29784139
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26292566
8Medulloblastoma (HP:0002885)4.09386206
9Carpal bone hypoplasia (HP:0001498)4.01598943
10Oligodactyly (hands) (HP:0001180)3.99747663
11Astrocytoma (HP:0009592)3.85555145
12Abnormality of the astrocytes (HP:0100707)3.85555145
13Lip pit (HP:0100267)3.84395625
14Rhabdomyosarcoma (HP:0002859)3.79175581
15Breast hypoplasia (HP:0003187)3.73722692
16Papillary thyroid carcinoma (HP:0002895)3.59588519
17Neoplasm of the oral cavity (HP:0100649)3.57594015
18Absent radius (HP:0003974)3.57085852
19Colon cancer (HP:0003003)3.49325009
20Birth length less than 3rd percentile (HP:0003561)3.47041657
21Supernumerary spleens (HP:0009799)3.39968231
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.39058792
23Selective tooth agenesis (HP:0001592)3.37989406
24Absent forearm bone (HP:0003953)3.36079767
25Aplasia involving forearm bones (HP:0009822)3.36079767
26Hypophosphatemic rickets (HP:0004912)3.35987898
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.31540469
28Glioma (HP:0009733)3.30437210
29Absent septum pellucidum (HP:0001331)3.28616177
30Agnosia (HP:0010524)3.27454434
31Impulsivity (HP:0100710)3.18883402
32Aplasia/Hypoplasia of the fovea (HP:0008060)3.18385280
33Hypoplasia of the fovea (HP:0007750)3.18385280
34Median cleft lip (HP:0000161)3.17026157
35Neoplasm of striated muscle (HP:0009728)3.15750817
36Abnormality of the lower motor neuron (HP:0002366)3.11000293
37Absent thumb (HP:0009777)3.09555789
38Short tibia (HP:0005736)3.09455306
39Abnormality of the fovea (HP:0000493)3.07846606
40Septo-optic dysplasia (HP:0100842)3.06478725
41Shawl scrotum (HP:0000049)3.04584504
42Patellar aplasia (HP:0006443)3.01152012
43Capillary hemangiomas (HP:0005306)3.00391589
44Aplasia/hypoplasia of the humerus (HP:0006507)2.99093752
45Abnormality of the septum pellucidum (HP:0007375)2.98331935
46Oligodactyly (HP:0012165)2.97636005
47Abnormality of chromosome stability (HP:0003220)2.93064946
48Meckel diverticulum (HP:0002245)2.91552557
49Male infertility (HP:0003251)2.87720782
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.85776885
51Abnormality of the ileum (HP:0001549)2.81296190
52Short humerus (HP:0005792)2.80875987
53Rectal fistula (HP:0100590)2.79181175
54Rectovaginal fistula (HP:0000143)2.79181175
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.74989746
56Aplasia/Hypoplasia of the patella (HP:0006498)2.72523154
57Rib fusion (HP:0000902)2.72039282
58Abnormality of the preputium (HP:0100587)2.62796893
59Sensory axonal neuropathy (HP:0003390)2.62009105
60Infertility (HP:0000789)2.61870248
61Biliary tract neoplasm (HP:0100574)2.60621911
62Stenosis of the external auditory canal (HP:0000402)2.59245650
63Abdominal situs inversus (HP:0003363)2.57998314
64Abnormality of abdominal situs (HP:0011620)2.57998314
65Missing ribs (HP:0000921)2.57002880
66Basal cell carcinoma (HP:0002671)2.54565760
67Fair hair (HP:0002286)2.54036922
68Ectopic kidney (HP:0000086)2.52604680
69Abnormality of the salivary glands (HP:0010286)2.51967179
70Abnormal spermatogenesis (HP:0008669)2.50544003
71Abnormality of DNA repair (HP:0003254)2.50190412
72Facial hemangioma (HP:0000329)2.48638149
73Azoospermia (HP:0000027)2.48547617
74Metaphyseal cupping (HP:0003021)2.47224689
75Intestinal fistula (HP:0100819)2.42911059
76Degeneration of anterior horn cells (HP:0002398)2.41797258
77Abnormality of the anterior horn cell (HP:0006802)2.41797258
78Duodenal stenosis (HP:0100867)2.37960753
79Small intestinal stenosis (HP:0012848)2.37960753
80Thyroid carcinoma (HP:0002890)2.35463589
81Proximal tubulopathy (HP:0000114)2.34012499
82Vaginal fistula (HP:0004320)2.34006705
83Horseshoe kidney (HP:0000085)2.33891439
84Proximal placement of thumb (HP:0009623)2.32453692
85Enlarged penis (HP:0000040)2.31749688
86Gonadotropin excess (HP:0000837)2.31143064
87Duplicated collecting system (HP:0000081)2.28492038
88Stillbirth (HP:0003826)2.27281390
89Oral leukoplakia (HP:0002745)2.25480130
90Embryonal renal neoplasm (HP:0011794)2.25093644
91Triphalangeal thumb (HP:0001199)2.23033226
92Anterior segment dysgenesis (HP:0007700)2.22277927
93Abnormality of chromosome segregation (HP:0002916)2.19360824
94Neoplasm of the pancreas (HP:0002894)2.19164841
95Cerebral hypomyelination (HP:0006808)2.18728928
96Reticulocytopenia (HP:0001896)2.18088082
9711 pairs of ribs (HP:0000878)2.17896684
98Deviation of the thumb (HP:0009603)2.12808135
99Premature ovarian failure (HP:0008209)2.12711200
100Abnormal lung lobation (HP:0002101)2.12219738
101Tongue fasciculations (HP:0001308)2.08954222
102Increased nuchal translucency (HP:0010880)2.08181206
103Poikiloderma (HP:0001029)2.07596013
104High anterior hairline (HP:0009890)2.06973477
105Volvulus (HP:0002580)2.05753611
106Trismus (HP:0000211)2.04558165
107Gastrointestinal carcinoma (HP:0002672)2.04531466
108Malignant gastrointestinal tract tumors (HP:0006749)2.04531466
109Aplasia of the musculature (HP:0100854)2.03685263
110Esophageal atresia (HP:0002032)2.03549459
111Limb hypertonia (HP:0002509)2.03144933
112Abnormality of the duodenum (HP:0002246)2.02862000
113Sloping forehead (HP:0000340)2.02845581
114Aplasia/Hypoplasia of the tongue (HP:0010295)2.02615220
115Spinal muscular atrophy (HP:0007269)2.02446996
116Atrophy/Degeneration involving motor neurons (HP:0007373)2.00882179
117Clubbing of toes (HP:0100760)2.00503590
118Cafe-au-lait spot (HP:0000957)2.00284480
119Supernumerary ribs (HP:0005815)2.00229490
120Abnormality of pyrimidine metabolism (HP:0004353)1.99677972
121Nephroblastoma (Wilms tumor) (HP:0002667)1.99003397
122Tracheoesophageal fistula (HP:0002575)1.98444200
123Vertebral clefting (HP:0008428)1.98038632
124Clitoromegaly (HP:0000057)1.97766511
125Generalized aminoaciduria (HP:0002909)1.97030694
126Wrist flexion contracture (HP:0001239)1.96444773
127Bile duct proliferation (HP:0001408)1.95918723
128Abnormal biliary tract physiology (HP:0012439)1.95918723
129Abnormal number of incisors (HP:0011064)1.94681561
130Fused cervical vertebrae (HP:0002949)1.94232073
131Short thumb (HP:0009778)1.93637936
132Muscle stiffness (HP:0003552)1.92584794
133Supernumerary bones of the axial skeleton (HP:0009144)1.92564362
134Myelodysplasia (HP:0002863)1.91106396
135Abnormality of the phalanges of the hallux (HP:0010057)1.90947011
136Adenoma sebaceum (HP:0009720)1.90246908
137Angiofibromas (HP:0010615)1.90246908
138Anal stenosis (HP:0002025)1.89739590
139Abnormality of the carotid arteries (HP:0005344)1.88919585
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.88594415
141Muscle fibrillation (HP:0010546)1.84953747
142Heterotopia (HP:0002282)1.84025980
143Rough bone trabeculation (HP:0100670)1.83599805
144Malnutrition (HP:0004395)1.82988260
145Urethral obstruction (HP:0000796)1.82919697
146Pseudobulbar signs (HP:0002200)1.82754280
147Hypokinesia (HP:0002375)1.82065394
148Abnormality of the renal collecting system (HP:0004742)1.78978143
149Metaphyseal irregularity (HP:0003025)1.78298424
150Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74782105
151Popliteal pterygium (HP:0009756)1.74053569
152Intrahepatic cholestasis (HP:0001406)1.74029539
153Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73783072
154Choanal atresia (HP:0000453)1.73563741
155Bicornuate uterus (HP:0000813)1.73242395
156Aplasia/Hypoplasia of the macula (HP:0008059)1.70769385
157Truncal obesity (HP:0001956)1.67898078
158Conjunctival telangiectasia (HP:0000524)1.65412980
159Bifid tongue (HP:0010297)1.65407212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.98752848
2MAP3K134.80508867
3CDC74.46884083
4ARAF4.40474184
5WEE13.85416502
6TTK3.15181258
7BRSK23.13220512
8ACVR1B3.08627925
9BUB12.82989037
10EPHA22.63061646
11NEK62.51831302
12NEK22.47594955
13PLK12.27194408
14TAOK32.21306653
15BRD42.16330207
16NEK12.07050765
17CDK72.02530687
18ZAK2.02289040
19RAF11.92781714
20RPS6KB21.92320820
21CHEK21.85372723
22MOS1.78260065
23ATR1.73262286
24BRSK11.72798395
25PLK31.66713117
26TSSK61.64221381
27PNCK1.62464293
28SRPK11.53536172
29CHEK11.53282619
30STK38L1.53125065
31PLK41.51761848
32MST41.50909637
33PDK31.49430497
34PDK41.49430497
35EIF2AK11.47914822
36PASK1.45048727
37NUAK11.42761459
38TRIM281.41667051
39AKT31.31143006
40TNIK1.30793525
41CDK191.21467008
42ICK1.20124872
43AURKA1.19688227
44CDK41.19535914
45ALK1.19442218
46AURKB1.18091927
47ATM1.17498645
48PAK41.13164758
49SCYL21.12111311
50CDK21.09334229
51MKNK21.05932523
52STK391.04530729
53MAPKAPK31.03882605
54MKNK11.00657203
55PDK20.98849698
56TYRO30.98832655
57MAP3K80.98069127
58MARK30.96660494
59STK40.96347494
60MELK0.93894405
61MAP3K40.92404924
62MET0.90142622
63STK100.90028566
64MTOR0.87895159
65DYRK30.86373671
66LATS20.85336506
67PBK0.83351731
68MAP3K100.80406339
69CDK10.79786779
70TESK20.77427262
71EEF2K0.76389365
72STK30.76233816
73FLT30.75918857
74TGFBR10.73884048
75PRKCI0.71524268
76DMPK0.69725327
77CSNK1E0.68814575
78WNK40.68404897
79MUSK0.68186019
80NTRK20.67381086
81CDK60.65356529
82EIF2AK30.64955678
83PKN20.63271401
84NEK90.62617382
85CSNK2A20.61987906
86CSNK1D0.60659178
87BMPR1B0.60336225
88TLK10.57406729
89CSNK1G30.51609099
90PRKDC0.50710350
91MAP3K90.50567401
92CDK90.50346772
93WNK10.49398878
94MAP3K60.48830853
95PINK10.48517380
96PIM10.47998070
97VRK10.47682095
98BRAF0.47319343
99EIF2AK20.46397732
100CSNK2A10.45746748
101OXSR10.44284849
102MAPK140.44103752
103PAK10.43281844
104TIE10.43163487
105DYRK20.42417967
106GSK3B0.41056653
107CDK80.39246706
108CSNK1G20.38453599
109CCNB10.37305246
110BMPR20.35695241
111PIK3CG0.35639492
112ERBB40.34539325
113MAPK130.34157945
114DAPK10.34107387
115MAP3K50.33123658
116KSR10.32901298
117TNK20.32831905
118AKT20.31027920
119MAPK10.30695030
120LATS10.30523443
121BCKDK0.30456052
122MATK0.30343411
123STK240.30291032
124PRKG10.29890983
125AKT10.28358535
126CSNK1A1L0.28046934
127CLK10.27452814
128KSR20.27353594
129WNK30.26660187
130CAMK2A0.25646586
131MAPK100.25608629
132MAPK110.25531086
133PRKACB0.25395884
134NTRK30.24183521
135PLK20.23488999
136RPS6KA10.22345769
137RPS6KA40.22334432
138BCR0.21811937
139CSNK1G10.20609776
140PRKD30.20422966

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.99477385
2DNA replication_Homo sapiens_hsa030304.99324564
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.56585743
4RNA transport_Homo sapiens_hsa030133.51652095
5Homologous recombination_Homo sapiens_hsa034403.20827645
6Spliceosome_Homo sapiens_hsa030403.13990655
7Nucleotide excision repair_Homo sapiens_hsa034203.08482826
8Cell cycle_Homo sapiens_hsa041103.01954740
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95017875
10RNA polymerase_Homo sapiens_hsa030202.94079905
11One carbon pool by folate_Homo sapiens_hsa006702.84189129
12Base excision repair_Homo sapiens_hsa034102.80500332
13Fanconi anemia pathway_Homo sapiens_hsa034602.70581140
14Basal transcription factors_Homo sapiens_hsa030222.60982305
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.38893086
16mRNA surveillance pathway_Homo sapiens_hsa030152.28196539
17Non-homologous end-joining_Homo sapiens_hsa034502.24510222
18Proteasome_Homo sapiens_hsa030502.09377670
19RNA degradation_Homo sapiens_hsa030181.91750739
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87703913
21Pyrimidine metabolism_Homo sapiens_hsa002401.82953629
22Caffeine metabolism_Homo sapiens_hsa002321.76363851
23Ribosome_Homo sapiens_hsa030101.70066115
24Ovarian steroidogenesis_Homo sapiens_hsa049131.63685079
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.63421381
26Oocyte meiosis_Homo sapiens_hsa041141.63332553
27Olfactory transduction_Homo sapiens_hsa047401.59248861
28p53 signaling pathway_Homo sapiens_hsa041151.54407412
29Selenocompound metabolism_Homo sapiens_hsa004501.38911859
30Biosynthesis of amino acids_Homo sapiens_hsa012301.16434640
31Propanoate metabolism_Homo sapiens_hsa006401.14239181
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.12427410
33Circadian rhythm_Homo sapiens_hsa047101.10198818
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08089711
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04580913
36Epstein-Barr virus infection_Homo sapiens_hsa051691.02650176
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98769992
38Purine metabolism_Homo sapiens_hsa002300.93269159
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92034395
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.91334103
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84661460
42Thyroid cancer_Homo sapiens_hsa052160.81123112
43Fatty acid elongation_Homo sapiens_hsa000620.80491592
44Viral carcinogenesis_Homo sapiens_hsa052030.80453509
45Phototransduction_Homo sapiens_hsa047440.79265923
46Hippo signaling pathway_Homo sapiens_hsa043900.78299903
47Vitamin B6 metabolism_Homo sapiens_hsa007500.77427287
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77414541
49MicroRNAs in cancer_Homo sapiens_hsa052060.76611887
50TGF-beta signaling pathway_Homo sapiens_hsa043500.74617776
51Gap junction_Homo sapiens_hsa045400.74307619
52Herpes simplex infection_Homo sapiens_hsa051680.69371230
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68670876
54ABC transporters_Homo sapiens_hsa020100.67069912
55Folate biosynthesis_Homo sapiens_hsa007900.66442427
56Notch signaling pathway_Homo sapiens_hsa043300.66131866
57Nicotine addiction_Homo sapiens_hsa050330.64046636
58HTLV-I infection_Homo sapiens_hsa051660.62995905
59Fructose and mannose metabolism_Homo sapiens_hsa000510.61665916
60Carbon metabolism_Homo sapiens_hsa012000.61208468
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60827171
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60687585
63Lysine degradation_Homo sapiens_hsa003100.60493507
64Basal cell carcinoma_Homo sapiens_hsa052170.60342295
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59939002
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57418156
67Systemic lupus erythematosus_Homo sapiens_hsa053220.57115842
68Adherens junction_Homo sapiens_hsa045200.54268700
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.53882826
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52825837
71mTOR signaling pathway_Homo sapiens_hsa041500.51608910
72Pentose phosphate pathway_Homo sapiens_hsa000300.50144870
73Tight junction_Homo sapiens_hsa045300.49958760
74Hedgehog signaling pathway_Homo sapiens_hsa043400.47581188
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.44350131
76Glutathione metabolism_Homo sapiens_hsa004800.44337231
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44157389
78Morphine addiction_Homo sapiens_hsa050320.41996205
79Taste transduction_Homo sapiens_hsa047420.41959665
80Antigen processing and presentation_Homo sapiens_hsa046120.39892176
81Protein export_Homo sapiens_hsa030600.39806648
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37089125
83Colorectal cancer_Homo sapiens_hsa052100.35585153
84Vitamin digestion and absorption_Homo sapiens_hsa049770.35121294
85Long-term depression_Homo sapiens_hsa047300.35038794
86Regulation of autophagy_Homo sapiens_hsa041400.33515459
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33412899
88GABAergic synapse_Homo sapiens_hsa047270.33115754
89Dorso-ventral axis formation_Homo sapiens_hsa043200.31422015
90Linoleic acid metabolism_Homo sapiens_hsa005910.30937240
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30903670
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30747581
93Bile secretion_Homo sapiens_hsa049760.28815195
94Huntingtons disease_Homo sapiens_hsa050160.28313827
95HIF-1 signaling pathway_Homo sapiens_hsa040660.26352140
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25757389
97Pathways in cancer_Homo sapiens_hsa052000.25157478
98Small cell lung cancer_Homo sapiens_hsa052220.25135915
99Galactose metabolism_Homo sapiens_hsa000520.24221800
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24071142
101Serotonergic synapse_Homo sapiens_hsa047260.23622997
102Wnt signaling pathway_Homo sapiens_hsa043100.23348848
103Bladder cancer_Homo sapiens_hsa052190.21946971
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21580627
105Pyruvate metabolism_Homo sapiens_hsa006200.21030768
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19874726
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19667297
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18439546
109Fatty acid biosynthesis_Homo sapiens_hsa000610.16412588
110Synaptic vesicle cycle_Homo sapiens_hsa047210.15359478
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15349553
112Arginine and proline metabolism_Homo sapiens_hsa003300.14414667
113Alcoholism_Homo sapiens_hsa050340.14115858
114Arachidonic acid metabolism_Homo sapiens_hsa005900.13117563
115Parkinsons disease_Homo sapiens_hsa050120.13103579
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13023637
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12151450
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11695379
119Prostate cancer_Homo sapiens_hsa052150.11524371
120Metabolic pathways_Homo sapiens_hsa011000.08643225
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.08210903
122Cardiac muscle contraction_Homo sapiens_hsa042600.07897457
123Legionellosis_Homo sapiens_hsa051340.07854388
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07170796
125Butanoate metabolism_Homo sapiens_hsa006500.06663165
126ErbB signaling pathway_Homo sapiens_hsa040120.06258061
127Glycerolipid metabolism_Homo sapiens_hsa005610.05379688
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04925198
129FoxO signaling pathway_Homo sapiens_hsa040680.03837406
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03228195
131AMPK signaling pathway_Homo sapiens_hsa041520.03130199
132Influenza A_Homo sapiens_hsa051640.02888088
133Apoptosis_Homo sapiens_hsa042100.02133497
134Arginine biosynthesis_Homo sapiens_hsa002200.01922170
135Melanoma_Homo sapiens_hsa052180.01627905
136Inositol phosphate metabolism_Homo sapiens_hsa005620.00810956
137Proteoglycans in cancer_Homo sapiens_hsa05205-0.0032304

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