SOD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.30995051
2negative regulation of interleukin-12 production (GO:0032695)5.25521779
3tricarboxylic acid cycle (GO:0006099)5.18411942
4NADH metabolic process (GO:0006734)4.20703438
5regulation of T-helper 1 cell differentiation (GO:0045625)4.17931662
6regulation of vitamin metabolic process (GO:0030656)4.16238912
7positive regulation of chemokine biosynthetic process (GO:0045080)4.10196379
8regulation of chronic inflammatory response (GO:0002676)4.09795264
9positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.08305297
10regulation of sequestering of triglyceride (GO:0010889)4.04181291
11positive regulation of heat generation (GO:0031652)4.02653394
12regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.01251460
13type I interferon signaling pathway (GO:0060337)3.97562788
14cellular response to type I interferon (GO:0071357)3.97562788
15response to type I interferon (GO:0034340)3.97413133
16response to peptidoglycan (GO:0032494)3.95521314
17positive regulation of gamma-delta T cell activation (GO:0046645)3.91824318
18germinal center formation (GO:0002467)3.89939833
19regulation of cytokine secretion involved in immune response (GO:0002739)3.89173933
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83472623
21positive regulation of lipid storage (GO:0010884)3.79371304
22T-helper 1 type immune response (GO:0042088)3.78963617
23* respiratory electron transport chain (GO:0022904)3.77360586
24lysine metabolic process (GO:0006553)3.73304392
25lysine catabolic process (GO:0006554)3.73304392
26regulation of acyl-CoA biosynthetic process (GO:0050812)3.72254007
27regulation of fever generation (GO:0031620)3.67830873
28regulation of interferon-beta biosynthetic process (GO:0045357)3.65436748
29* electron transport chain (GO:0022900)3.64445285
30oxidative phosphorylation (GO:0006119)3.63351523
31succinate metabolic process (GO:0006105)3.60775980
32positive regulation by symbiont of host defense response (GO:0052509)3.59280967
33modulation by symbiont of host defense response (GO:0052031)3.59280967
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59280967
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59280967
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.59280967
37modulation by symbiont of host immune response (GO:0052553)3.59280967
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57409374
39* hydrogen peroxide biosynthetic process (GO:0050665)3.55563096
40positive regulation of type 2 immune response (GO:0002830)3.55147309
41regulation of cofactor metabolic process (GO:0051193)3.51263107
42regulation of coenzyme metabolic process (GO:0051196)3.51263107
43oxaloacetate metabolic process (GO:0006107)3.50292321
44regulation of chemokine biosynthetic process (GO:0045073)3.48487466
45regulation of podosome assembly (GO:0071801)3.48112934
46defense response to protozoan (GO:0042832)3.43178014
47regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.42789266
48interferon-gamma-mediated signaling pathway (GO:0060333)3.42640277
492-oxoglutarate metabolic process (GO:0006103)3.42570536
50regulation of interleukin-12 biosynthetic process (GO:0045075)3.42116161
51response to protozoan (GO:0001562)3.40554490
52low-density lipoprotein particle clearance (GO:0034383)3.40337870
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39447376
54aldehyde catabolic process (GO:0046185)3.38417138
55negative regulation of cytokine production involved in immune response (GO:0002719)3.36188404
56positive regulation of NF-kappaB import into nucleus (GO:0042346)3.33071930
57regulation of interleukin-8 biosynthetic process (GO:0045414)3.30055963
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.28149480
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27805093
60ATP synthesis coupled proton transport (GO:0015986)3.27805093
61positive regulation of toll-like receptor signaling pathway (GO:0034123)3.22736937
62regulation of interleukin-12 production (GO:0032655)3.21962704
63fatty acid beta-oxidation (GO:0006635)3.21167582
64respiratory burst (GO:0045730)3.20381032
65macrophage activation (GO:0042116)3.18529419
66regulation of cholesterol storage (GO:0010885)3.17991737
67branching involved in labyrinthine layer morphogenesis (GO:0060670)3.16463979
68negative regulation of cell killing (GO:0031342)3.16417189
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16417189
70positive regulation of cellular amide metabolic process (GO:0034250)3.16348973
71positive regulation of interferon-beta production (GO:0032728)3.16121981
72NIK/NF-kappaB signaling (GO:0038061)3.14909588
73regulation of membrane protein ectodomain proteolysis (GO:0051043)3.14854580
74response to muramyl dipeptide (GO:0032495)3.12780137
75fatty acid transmembrane transport (GO:1902001)3.10250554
76positive regulation of acute inflammatory response (GO:0002675)3.08084403
77neutrophil activation involved in immune response (GO:0002283)3.07476564
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06580936
79regulation of T-helper 2 cell differentiation (GO:0045628)3.06285470
80* reactive oxygen species biosynthetic process (GO:1903409)3.04550922
81immunoglobulin mediated immune response (GO:0016064)3.03497398
82tryptophan catabolic process (GO:0006569)3.03235243
83indole-containing compound catabolic process (GO:0042436)3.03235243
84indolalkylamine catabolic process (GO:0046218)3.03235243
85granulocyte activation (GO:0036230)3.02798065
86sarcoplasmic reticulum calcium ion transport (GO:0070296)3.01587367
87aspartate family amino acid catabolic process (GO:0009068)2.99539468
88cellular response to lipopolysaccharide (GO:0071222)2.99091638
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98850623
90cellular response to molecule of bacterial origin (GO:0071219)2.98683384
91phagosome maturation (GO:0090382)2.98430929
92microglial cell activation (GO:0001774)2.97595380
93NAD metabolic process (GO:0019674)2.97382029
94regulation of lipid storage (GO:0010883)2.96423308
95branched-chain amino acid catabolic process (GO:0009083)2.95930914
96regulation of NF-kappaB import into nucleus (GO:0042345)2.94626263
97regulation of heterotypic cell-cell adhesion (GO:0034114)2.92493983
98regulation of gamma-delta T cell activation (GO:0046643)2.92260787
99kynurenine metabolic process (GO:0070189)2.92031535
100carnitine shuttle (GO:0006853)2.91780655
101myeloid dendritic cell differentiation (GO:0043011)2.91454931
102* positive regulation of nitric oxide biosynthetic process (GO:0045429)2.88434747
103regulation of type 2 immune response (GO:0002828)2.85567175
104positive regulation of interleukin-6 production (GO:0032755)2.85108331
105regulation of heat generation (GO:0031650)2.83849336
106plasma lipoprotein particle clearance (GO:0034381)2.82568300
107detection of external biotic stimulus (GO:0098581)2.82213531
108regulation of T-helper cell differentiation (GO:0045622)2.82021358
109* regulation of nitric oxide biosynthetic process (GO:0045428)2.81943876
110interferon-gamma secretion (GO:0072643)2.81504112
111detection of other organism (GO:0098543)2.79925524
112lipid oxidation (GO:0034440)2.79868039
113positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.79073098
114positive regulation of interferon-alpha production (GO:0032727)2.78982136
115fatty acid oxidation (GO:0019395)2.78949838
116negative regulation of lipid storage (GO:0010888)2.78674705
117acetyl-CoA metabolic process (GO:0006084)2.78624962
118regulation of growth of symbiont in host (GO:0044126)2.78318682
119negative regulation of growth of symbiont in host (GO:0044130)2.78318682
120negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.78318682
121modulation of growth of symbiont involved in interaction with host (GO:0044144)2.78318682
122positive regulation of interleukin-12 production (GO:0032735)2.77611229
123fatty acid catabolic process (GO:0009062)2.77610801
124positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.77489006
125cellular ketone body metabolic process (GO:0046950)2.75846275
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75553047
127negative regulation of production of molecular mediator of immune response (GO:0002701)2.74743720
128branched-chain amino acid metabolic process (GO:0009081)2.74013379
129tricarboxylic acid metabolic process (GO:0072350)2.73613368
130cofactor catabolic process (GO:0051187)2.73520870
131lymphocyte chemotaxis (GO:0048247)2.73107569
132nucleoside diphosphate biosynthetic process (GO:0009133)2.72873708
133negative regulation of viral genome replication (GO:0045071)2.72617675
134monocyte chemotaxis (GO:0002548)2.70474279
135sarcomere organization (GO:0045214)2.70381759
136negative regulation of nitric oxide biosynthetic process (GO:0045019)2.70066625
137regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.69777458
138positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.68857544
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68814557
140myeloid cell activation involved in immune response (GO:0002275)2.68638879
141positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68610241
142neutrophil activation (GO:0042119)2.68466328
143regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.68444687
144glyoxylate metabolic process (GO:0046487)2.68365829
145heart process (GO:0003015)2.68348208
146heart contraction (GO:0060047)2.68348208
147valine metabolic process (GO:0006573)2.67969993
148negative regulation of T cell mediated immunity (GO:0002710)2.67810612
149cellular response to interferon-gamma (GO:0071346)2.67457727
150regulation of toll-like receptor signaling pathway (GO:0034121)2.67350139
151regulation of sulfur metabolic process (GO:0042762)2.67263746
152macrophage activation involved in immune response (GO:0002281)2.65795213
153regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65016338
154regulation of interferon-alpha production (GO:0032647)2.63268724
155positive regulation of lipid catabolic process (GO:0050996)2.62503350
156regulation of relaxation of muscle (GO:1901077)2.62065657
157cellular response to zinc ion (GO:0071294)2.61287884
158myofibril assembly (GO:0030239)2.56974769
159carnitine metabolic process (GO:0009437)2.56819324
160negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.55203256
161response to host immune response (GO:0052572)2.50987202
162response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50987202
163lipid storage (GO:0019915)2.50840253
164monocarboxylic acid catabolic process (GO:0072329)2.50117736
165regulation of mononuclear cell migration (GO:0071675)2.49767419
166negative regulation of lipid catabolic process (GO:0050995)2.49417772
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.49295771
168short-chain fatty acid metabolic process (GO:0046459)2.49183607
169amino-acid betaine metabolic process (GO:0006577)2.48435902
170detection of molecule of bacterial origin (GO:0032490)2.47105168
171triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.45831685
172cysteine metabolic process (GO:0006534)2.41765720
173ATP hydrolysis coupled proton transport (GO:0015991)2.41452286
174energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.41452286
175fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.41350567
176negative regulation of myeloid cell apoptotic process (GO:0033033)2.40489569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.91042028
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.70829939
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.60131716
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.67272022
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.60901397
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.91905504
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.47794675
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.46265942
9* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.45756520
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.44434804
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34599008
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31526602
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19983538
14SMAD_19615063_ChIP-ChIP_OVARY_Human3.16212261
15LXR_22158963_ChIP-Seq_LIVER_Mouse3.04404268
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.01732109
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.96277603
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.73114356
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68546335
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.42115610
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.30579696
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28827452
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19490971
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17251553
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15851475
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.13429592
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02945062
28RUNX_20019798_ChIP-Seq_JUKART_Human1.88440958
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86166457
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79943592
31* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71906736
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70295165
33SPI1_23127762_ChIP-Seq_K562_Human1.68052135
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65388654
35SCL_19346495_ChIP-Seq_HPC-7_Human1.58488054
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58283535
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57402657
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.56791415
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.56777602
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54547088
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.50340686
42GATA1_22025678_ChIP-Seq_K562_Human1.49573327
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46914931
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46425463
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45205823
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37253205
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37253205
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36981828
49VDR_24763502_ChIP-Seq_THP-1_Human1.36002865
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35968831
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35351500
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34967778
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.31848049
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25310775
55EGR1_19032775_ChIP-ChIP_M12_Human1.25006315
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22937995
57MYB_26560356_Chip-Seq_TH2_Human1.20564458
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19824710
59* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18489062
60VDR_22108803_ChIP-Seq_LS180_Human1.18289138
61* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16402393
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15604667
63TP53_16413492_ChIP-PET_HCT116_Human1.15025372
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12301426
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11129295
66* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09027811
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09009899
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.08518638
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08507579
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06675380
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06043230
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04805262
73GATA1_19941826_ChIP-Seq_K562_Human1.04625925
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04157322
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04156251
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.01532064
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00242543
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99616863
79KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98044584
80STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96448340
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96019668
82GATA3_27048872_Chip-Seq_THYMUS_Human0.95956835
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95107686
84* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94899991
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94400468
86* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93986192
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93843090
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93621251
89MAF_26560356_Chip-Seq_TH1_Human0.92940746
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91041661
91MYB_26560356_Chip-Seq_TH1_Human0.89487197
92RUNX1_22412390_ChIP-Seq_EML_Mouse0.88188066
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88117924
94SPI1_20517297_ChIP-Seq_HL60_Human0.87328123
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87310539
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86513495
97ZNF263_19887448_ChIP-Seq_K562_Human0.86308781
98* CJUN_26792858_Chip-Seq_BT549_Human0.84680046
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84633228
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84311392
101* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83858315
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83495701
103* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82704576
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.81990215
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81481273
106GATA4_21415370_ChIP-Seq_HL-1_Mouse0.81458278
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81148833
108YY1_21170310_ChIP-Seq_MESCs_Mouse0.80561530
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80230234
110GATA2_19941826_ChIP-Seq_K562_Human0.80139887
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.80038770
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79851615
113ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78956228
114TAF2_19829295_ChIP-Seq_ESCs_Human0.78630869
115* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78451988
116VDR_24787735_ChIP-Seq_THP-1_Human0.77552162
117SMRT_27268052_Chip-Seq_Bcells_Human0.77152976
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77142615
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.75717119
120TBX20_22328084_ChIP-Seq_HEART_Mouse0.75717119
121TCF7_22412390_ChIP-Seq_EML_Mouse0.74950551
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74455214
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74444798
124VDR_21846776_ChIP-Seq_THP-1_Human0.73456206
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72482971
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72419246
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72322892
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72292704
129BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71913216
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.71653325
131* PU_27001747_Chip-Seq_BMDM_Mouse0.70673806
132GATA3_26560356_Chip-Seq_TH2_Human0.70284916
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.69824688
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.69822199
135HTT_18923047_ChIP-ChIP_STHdh_Human0.69625969
136TP63_23658742_ChIP-Seq_EP156T_Human0.69420417
137SALL4_22934838_ChIP-ChIP_CD34+_Human0.69186078
138SPI1_23547873_ChIP-Seq_NB4_Human0.68892392
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.68813618
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68478893
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.66926407
142STAT1_20625510_ChIP-Seq_HELA_Human0.66784509
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.66680874
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66303163
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66210660
146GABP_17652178_ChIP-ChIP_JURKAT_Human0.65957886
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65756532
148RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.65657451
149STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.65239540
150LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.65009994
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64944880
152* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.63608236
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63564994
154CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63472063
155BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62075401
156KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.62011726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.76568197
2* MP0003646_muscle_fatigue3.67352722
3MP0002139_abnormal_hepatobiliary_system2.94699742
4MP0003300_gastrointestinal_ulcer2.79536556
5MP0004084_abnormal_cardiac_muscle2.76414378
6MP0003806_abnormal_nucleotide_metabolis2.73575470
7MP0009785_altered_susceptibility_to2.69959641
8MP0003724_increased_susceptibility_to2.63361719
9MP0005360_urolithiasis2.61796845
10MP0004215_abnormal_myocardial_fiber2.49248449
11MP0004510_myositis2.42330650
12MP0005085_abnormal_gallbladder_physiolo2.35204442
13MP0005671_abnormal_response_to2.34756364
14MP0009840_abnormal_foam_cell2.31216448
15MP0001800_abnormal_humoral_immune2.25420713
16MP0008775_abnormal_heart_ventricle2.25034088
17* MP0006036_abnormal_mitochondrial_physio2.24285062
18* MP0004130_abnormal_muscle_cell2.23800942
19MP0004036_abnormal_muscle_relaxation2.23533671
20MP0003436_decreased_susceptibility_to2.14785886
21MP0000751_myopathy2.11429651
22* MP0003186_abnormal_redox_activity2.08562718
23MP0008004_abnormal_stomach_pH2.05411222
24MP0009764_decreased_sensitivity_to2.00521808
25MP0005332_abnormal_amino_acid1.98767862
26MP0000343_altered_response_to1.98367179
27MP0000749_muscle_degeneration1.97356929
28MP0006054_spinal_hemorrhage1.96711153
29* MP0005330_cardiomyopathy1.95552984
30MP0006082_CNS_inflammation1.88679307
31MP0002148_abnormal_hypersensitivity_rea1.87790877
32MP0005365_abnormal_bile_salt1.87320835
33MP0009278_abnormal_bone_marrow1.83573750
34MP0005083_abnormal_biliary_tract1.83477964
35MP0005058_abnormal_lysosome_morphology1.82330207
36* MP0002332_abnormal_exercise_endurance1.82166280
37MP0000685_abnormal_immune_system1.81380771
38MP0002254_reproductive_system_inflammat1.78650823
39MP0010155_abnormal_intestine_physiology1.77360874
40* MP0002972_abnormal_cardiac_muscle1.75852992
41MP0002419_abnormal_innate_immunity1.75413993
42MP0003303_peritoneal_inflammation1.73810170
43MP0001835_abnormal_antigen_presentation1.73618996
44MP0001819_abnormal_immune_cell1.73446881
45MP0002420_abnormal_adaptive_immunity1.72702990
46MP0003191_abnormal_cellular_cholesterol1.70871790
47MP0001544_abnormal_cardiovascular_syste1.68921561
48MP0005385_cardiovascular_system_phenoty1.68921561
49* MP0005535_abnormal_body_temperature1.68910008
50* MP0005319_abnormal_enzyme/_coenzyme1.65517645
51MP0003828_pulmonary_edema1.65345346
52MP0002405_respiratory_system_inflammati1.64689414
53MP0008875_abnormal_xenobiotic_pharmacok1.63488541
54MP0005310_abnormal_salivary_gland1.59949228
55MP0005025_abnormal_response_to1.59261493
56MP0000750_abnormal_muscle_regeneration1.54733987
57MP0003172_abnormal_lysosome_physiology1.53759561
58MP0005397_hematopoietic_system_phenotyp1.52676196
59MP0001545_abnormal_hematopoietic_system1.52676196
60* MP0008469_abnormal_protein_level1.49197699
61MP0004484_altered_response_of1.46365394
62MP0003453_abnormal_keratinocyte_physiol1.46244133
63MP0002998_abnormal_bone_remodeling1.44260028
64MP0003448_altered_tumor_morphology1.43731456
65MP0000569_abnormal_digit_pigmentation1.42739340
66MP0003075_altered_response_to1.42257894
67* MP0004087_abnormal_muscle_fiber1.41098521
68MP0005167_abnormal_blood-brain_barrier1.39399172
69MP0010329_abnormal_lipoprotein_level1.38228165
70MP0005000_abnormal_immune_tolerance1.37450766
71* MP0005584_abnormal_enzyme/coenzyme_acti1.34509113
72* MP0005620_abnormal_muscle_contractility1.34083762
73MP0001764_abnormal_homeostasis1.33178827
74MP0001853_heart_inflammation1.32825913
75MP0005451_abnormal_body_composition1.31660706
76MP0003656_abnormal_erythrocyte_physiolo1.28166931
77* MP0006035_abnormal_mitochondrial_morpho1.28110510
78MP0000604_amyloidosis1.27405823
79MP0005670_abnormal_white_adipose1.24697363
80* MP0002118_abnormal_lipid_homeostasis1.24238155
81MP0005666_abnormal_adipose_tissue1.22729548
82MP0001501_abnormal_sleep_pattern1.22580294
83* MP0000716_abnormal_immune_system1.21626292
84* MP0002106_abnormal_muscle_physiology1.20162396
85MP0002971_abnormal_brown_adipose1.18107359
86MP0001533_abnormal_skeleton_physiology1.15971972
87MP0002138_abnormal_hepatobiliary_system1.15927275
88* MP0003221_abnormal_cardiomyocyte_apopto1.15155143
89MP0003045_fibrosis1.10336130
90* MP0000609_abnormal_liver_physiology1.10135839
91MP0008260_abnormal_autophagy1.09813671
92MP0005166_decreased_susceptibility_to1.09081839
93MP0003091_abnormal_cell_migration1.08819932
94MP0003137_abnormal_impulse_conducting1.08742187
95MP0005165_increased_susceptibility_to1.08218618
96MP0000858_altered_metastatic_potential1.07221884
97MP0001845_abnormal_inflammatory_respons1.06137696
98MP0009763_increased_sensitivity_to1.05929653
99MP0004782_abnormal_surfactant_physiolog1.05767030
100MP0009333_abnormal_splenocyte_physiolog1.03064937
101MP0004883_abnormal_blood_vessel1.01433642
102* MP0005266_abnormal_metabolism1.01027561
103MP0004858_abnormal_nervous_system1.00392221
104MP0010352_gastrointestinal_tract_polyps0.99901762
105MP0006138_congestive_heart_failure0.99120220
106* MP0010630_abnormal_cardiac_muscle0.98256390
107* MP0002398_abnormal_bone_marrow0.97394109
108MP0002269_muscular_atrophy0.97043022
109MP0009697_abnormal_copulation0.97014787
110MP0009765_abnormal_xenobiotic_induced0.96472504
111MP0002876_abnormal_thyroid_physiology0.94149199
112* MP0002078_abnormal_glucose_homeostasis0.93340262
113* MP0009643_abnormal_urine_homeostasis0.93046974
114MP0003252_abnormal_bile_duct0.92442728
115MP0004019_abnormal_vitamin_homeostasis0.92437225
116* MP0005376_homeostasis/metabolism_phenot0.90489065
117MP0009046_muscle_twitch0.89082955
118MP0003763_abnormal_thymus_physiology0.87335060
119MP0005387_immune_system_phenotype0.87262341
120MP0001790_abnormal_immune_system0.87262341
121MP0005164_abnormal_response_to0.86207756
122MP0001663_abnormal_digestive_system0.85784964
123MP0002723_abnormal_immune_serum0.84746860
124* MP0002429_abnormal_blood_cell0.84729569
125MP0005390_skeleton_phenotype0.84720110
126MP0000689_abnormal_spleen_morphology0.84131457
127* MP0005369_muscle_phenotype0.83064517
128MP0002452_abnormal_antigen_presenting0.82309458
129MP0000230_abnormal_systemic_arterial0.81752229
130MP0005076_abnormal_cell_differentiation0.81274936
131MP0002722_abnormal_immune_system0.80271845
132MP0004947_skin_inflammation0.79693561
133MP0003690_abnormal_glial_cell0.79310056
134MP0005464_abnormal_platelet_physiology0.78746247
135MP0001756_abnormal_urination0.78119970
136MP0005334_abnormal_fat_pad0.78079566
137MP0000249_abnormal_blood_vessel0.77728444
138MP0008874_decreased_physiological_sensi0.77540796
139* MP0003195_calcinosis0.77344435
140MP0000920_abnormal_myelination0.77019480
141MP0005647_abnormal_sex_gland0.72257322
142MP0001851_eye_inflammation0.72053042
143MP0002933_joint_inflammation0.71974269
144MP0004808_abnormal_hematopoietic_stem0.70910264
145MP0002277_abnormal_respiratory_mucosa0.69379005
146MP0005023_abnormal_wound_healing0.67650044
147MP0000371_diluted_coat_color0.66477156
148MP0003183_abnormal_peptide_metabolism0.65737938
149MP0003329_amyloid_beta_deposits0.58763067
150MP0003633_abnormal_nervous_system0.58633060
151MP0003950_abnormal_plasma_membrane0.57922398
152MP0005595_abnormal_vascular_smooth0.57352750
153MP0000465_gastrointestinal_hemorrhage0.56865593
154MP0009115_abnormal_fat_cell0.54400547
155MP0001542_abnormal_bone_strength0.53890419

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)6.44802890
2Retrobulbar optic neuritis (HP:0100654)6.44802890
3Orchitis (HP:0100796)6.23846531
4Myositis (HP:0100614)5.37861729
5Abnormality of glycolipid metabolism (HP:0010969)5.10618185
6Abnormality of liposaccharide metabolism (HP:0010968)5.10618185
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.10618185
8Keratoconjunctivitis sicca (HP:0001097)4.50930670
9Keratoconjunctivitis (HP:0001096)4.18155432
10Nausea (HP:0002018)4.13398241
11Increased cerebral lipofuscin (HP:0011813)4.12002094
12Recurrent gram-negative bacterial infections (HP:0005420)3.99181602
13Abnormal mitochondria in muscle tissue (HP:0008316)3.84593447
14Acute necrotizing encephalopathy (HP:0006965)3.82603603
15Hepatic necrosis (HP:0002605)3.79330908
16Disinhibition (HP:0000734)3.74422144
17Sudden death (HP:0001699)3.63292220
18Acute encephalopathy (HP:0006846)3.63111570
19Cerebral edema (HP:0002181)3.59115178
20Vacuolated lymphocytes (HP:0001922)3.51698745
21Eczematoid dermatitis (HP:0000976)3.50659610
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.50435557
23Hypoglycemic coma (HP:0001325)3.48407205
24Esophageal neoplasm (HP:0100751)3.45907486
25Neoplasm of head and neck (HP:0012288)3.45907486
26Abnormality of fatty-acid metabolism (HP:0004359)3.44601604
27Recurrent abscess formation (HP:0002722)3.42774845
28Loss of speech (HP:0002371)3.39197412
29Gangrene (HP:0100758)3.32660980
30Myoglobinuria (HP:0002913)3.27888612
31Dysostosis multiplex (HP:0000943)3.22997386
32Vasculitis (HP:0002633)3.21830036
33Exercise-induced muscle cramps (HP:0003710)3.20703651
34Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20383631
35Dicarboxylic aciduria (HP:0003215)3.20383631
36Generalized aminoaciduria (HP:0002909)3.18877872
37Hematochezia (HP:0002573)3.18436790
38Elevated erythrocyte sedimentation rate (HP:0003565)3.18024648
39Recurrent bacterial skin infections (HP:0005406)3.17868132
40Mitochondrial inheritance (HP:0001427)3.17125815
41Progressive macrocephaly (HP:0004481)3.16813120
42Hepatocellular necrosis (HP:0001404)3.14398423
43Pulmonary infiltrates (HP:0002113)3.13894627
44Hyperglycinuria (HP:0003108)3.11513978
45Increased CSF lactate (HP:0002490)3.10242906
46Ketoacidosis (HP:0001993)3.09879180
47Hemoptysis (HP:0002105)3.08296938
48T lymphocytopenia (HP:0005403)2.98098847
49Arterial thrombosis (HP:0004420)2.97103389
50Gastrointestinal infarctions (HP:0005244)2.94968530
51Axonal loss (HP:0003447)2.92589215
52Abnormality of T cell number (HP:0011839)2.89644947
53Rhabdomyolysis (HP:0003201)2.89526558
54Lactic acidosis (HP:0003128)2.89317927
55Palpitations (HP:0001962)2.88142117
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87004349
57Hyperammonemia (HP:0001987)2.86827851
58Calf muscle hypertrophy (HP:0008981)2.84824596
59Exercise-induced myalgia (HP:0003738)2.84363655
60Ventricular tachycardia (HP:0004756)2.84071846
61Ketosis (HP:0001946)2.81871142
62Abnormality of macrophages (HP:0004311)2.79651928
63Increased serum pyruvate (HP:0003542)2.79120962
64Abnormality of glycolysis (HP:0004366)2.79120962
65Lethargy (HP:0001254)2.77826637
66Amyloidosis (HP:0011034)2.76925488
67Proximal tubulopathy (HP:0000114)2.72487266
68Neurofibrillary tangles (HP:0002185)2.71154422
69Recurrent fungal infections (HP:0002841)2.69859053
70Encephalitis (HP:0002383)2.69300973
71Increased muscle lipid content (HP:0009058)2.66060961
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65743868
73Abnormality of polysaccharide metabolism (HP:0011012)2.65743868
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65743868
75Abnormality of alanine metabolism (HP:0010916)2.65344757
76Hyperalaninemia (HP:0003348)2.65344757
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65344757
78Recurrent skin infections (HP:0001581)2.63182860
79Autoimmune hemolytic anemia (HP:0001890)2.62022695
80Inappropriate behavior (HP:0000719)2.60758446
81Muscle hypertrophy of the lower extremities (HP:0008968)2.59520697
82Mutism (HP:0002300)2.58924167
83Glomerulonephritis (HP:0000099)2.58441923
84Abnormality of glycine metabolism (HP:0010895)2.56541266
85Abnormality of serine family amino acid metabolism (HP:0010894)2.56541266
86Abnormality of aromatic amino acid family metabolism (HP:0004338)2.54775286
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54735450
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54735450
89Autoimmune thrombocytopenia (HP:0001973)2.53802207
90Mediastinal lymphadenopathy (HP:0100721)2.52411033
91Respiratory failure (HP:0002878)2.52158457
92Lipoatrophy (HP:0100578)2.51988587
93Xanthomatosis (HP:0000991)2.51618619
94Interstitial pulmonary disease (HP:0006530)2.51089564
95Pheochromocytoma (HP:0002666)2.50862894
96Tetraparesis (HP:0002273)2.50611261
97Anorexia (HP:0002039)2.47528652
98Atrial fibrillation (HP:0005110)2.46952337
99Urinary glycosaminoglycan excretion (HP:0003541)2.45628731
100Mucopolysacchariduria (HP:0008155)2.45628731
101Parakeratosis (HP:0001036)2.45468192
102Systemic lupus erythematosus (HP:0002725)2.45000865
103Stomatitis (HP:0010280)2.41747264
104Vomiting (HP:0002013)2.41225064
105Increased intramyocellular lipid droplets (HP:0012240)2.40794010
106Abnormality of the pleura (HP:0002103)2.40696193
107Vertigo (HP:0002321)2.40667604
108Pulmonary embolism (HP:0002204)2.40586945
109Neuroendocrine neoplasm (HP:0100634)2.39383540
110Increased serum ferritin (HP:0003281)2.38072340
111Myocardial infarction (HP:0001658)2.37890525
112Muscle fiber splitting (HP:0003555)2.37884440
113Episodic fever (HP:0001954)2.37433294
114Hyperglycinemia (HP:0002154)2.37231136
115Polyneuropathy (HP:0001271)2.37176919
116Metabolic acidosis (HP:0001942)2.36193699
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35690115
118Abnormality of the vasculature of the conjunctiva (HP:0008054)2.35642692
119Syncope (HP:0001279)2.34291633
120Leukocytosis (HP:0001974)2.33655919
121Exercise intolerance (HP:0003546)2.33049955
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.32082313
123Abnormality of the pericardium (HP:0001697)2.30505073
124Recurrent viral infections (HP:0004429)2.29948626
125Primary atrial arrhythmia (HP:0001692)2.26981908
126Multiple enchondromatosis (HP:0005701)2.25477406
127Subaortic stenosis (HP:0001682)2.24258444
128Abnormality of the left ventricular outflow tract (HP:0011103)2.24258444
129Abnormality of the endocardium (HP:0004306)2.24181913
130Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23894322
131Asymmetric septal hypertrophy (HP:0001670)2.22832114
132Peritonitis (HP:0002586)2.22348017
133Abnormality of serum amino acid levels (HP:0003112)2.20980745
134Nuclear cataract (HP:0100018)2.20297406
135Increased serum lactate (HP:0002151)2.19660349
136Spontaneous hematomas (HP:0007420)2.18892966
137Supraventricular tachycardia (HP:0004755)2.18392077
138Lipid accumulation in hepatocytes (HP:0006561)2.17963696
139Meningitis (HP:0001287)2.16021167
140Hyperlipoproteinemia (HP:0010980)2.15327038
141Obstructive lung disease (HP:0006536)2.14743307
142Chronic obstructive pulmonary disease (HP:0006510)2.14743307
143Abnormality of purine metabolism (HP:0004352)2.14459501
144Keratitis (HP:0000491)2.14388109
145Acne (HP:0001061)2.13998042
146Abnormality of the calf musculature (HP:0001430)2.13212218
147Joint swelling (HP:0001386)2.13041643
148Increased IgM level (HP:0003496)2.11782846
149Dilated cardiomyopathy (HP:0001644)2.11153937
150Gingivitis (HP:0000230)2.11098530
151Abnormality of urine glucose concentration (HP:0011016)2.10387391
152Glycosuria (HP:0003076)2.10387391
153Supraventricular arrhythmia (HP:0005115)2.09573213
154Bundle branch block (HP:0011710)2.08466900
155Ragged-red muscle fibers (HP:0003200)2.07738730
156Cerebral inclusion bodies (HP:0100314)2.04874772
157Apathy (HP:0000741)2.03626898
158Hypoalphalipoproteinemia (HP:0003233)2.03591677
159Increased IgE level (HP:0003212)2.02840325
160Conjunctival hamartoma (HP:0100780)2.02138411
161Urticaria (HP:0001025)2.01830052
162Epidermoid cyst (HP:0200040)2.00928983
163Basal ganglia calcification (HP:0002135)1.99829951
164Gout (HP:0001997)1.99321385
165Skin nodule (HP:0200036)1.99075567
166CNS demyelination (HP:0007305)1.98228261
167Methylmalonic aciduria (HP:0012120)1.97454795
168Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96941329
169Prolonged partial thromboplastin time (HP:0003645)1.95702022
170Diminished motivation (HP:0000745)1.93591015
171Hydroxyprolinuria (HP:0003080)1.92965744
172Neoplasm of the tracheobronchial system (HP:0100552)1.92916337
173Abnormality of iron homeostasis (HP:0011031)1.92616633
174Malnutrition (HP:0004395)1.92398763
175Hypergammaglobulinemia (HP:0010702)1.91496460
176Complement deficiency (HP:0004431)1.86330874
177Glomerulopathy (HP:0100820)1.86050442
178Memory impairment (HP:0002354)1.85523635
179Abnormality of B cell number (HP:0010975)1.84738348
180Segmental peripheral demyelination/remyelination (HP:0003481)1.83741454
181Alveolar cell carcinoma (HP:0006519)1.82002259
182Recurrent bronchitis (HP:0002837)1.80792577
183Gingival bleeding (HP:0000225)1.79830315
184Agnosia (HP:0010524)1.79795366
185Arthralgia (HP:0002829)1.77795314
186Eosinophilia (HP:0001880)1.76387007
187Chest pain (HP:0100749)1.76352173
188Stomach cancer (HP:0012126)1.75074830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.26076826
2PBK3.72533830
3IRAK33.51344717
4BCKDK3.33922238
5PDK43.27734813
6PDK33.27734813
7MAP3K143.21519650
8FRK2.66977078
9PDK22.63118468
10TBK12.62609743
11ACVR1B2.38842757
12DDR22.37224587
13NEK12.25585672
14RIPK12.17904821
15OBSCN2.07100479
16NME22.06639280
17TTN2.03228390
18MYLK2.01102604
19PINK11.98693033
20TAOK11.94071725
21IRAK41.78677322
22MAP4K11.76553451
23ABL21.67764627
24ARAF1.66434243
25IKBKE1.64079306
26TYK21.64044913
27ADRBK21.61455834
28GRK71.53323081
29MAP2K31.50677889
30PHKG11.49248620
31PHKG21.49248620
32CDC42BPA1.48118629
33MAP3K51.44600819
34TGFBR21.40343315
35BLK1.40311892
36STK241.37685656
37BMPR21.25161111
38MOS1.24417116
39ERBB41.23082169
40ZAP701.22165454
41MUSK1.21840497
42NEK91.21445703
43ERN11.21332328
44MAP3K121.20549498
45TAOK31.20008368
46IKBKB1.19648408
47EIF2AK11.16532116
48EPHA31.16319617
49CASK1.14897439
50LMTK21.14757521
51MAP3K111.11644417
52JAK11.10369034
53ZAK1.05158430
54DAPK21.04912022
55JAK31.03818185
56DAPK31.02469129
57MST1R0.98503719
58AKT30.95696274
59STK38L0.94849974
60PIM20.91493218
61PLK20.90955903
62TXK0.89273893
63MAP3K130.88281334
64PIK3CA0.84875161
65TYRO30.82680000
66PDPK10.77184156
67EPHB10.76951047
68HCK0.75754316
69PRKCD0.75495618
70JAK20.73418632
71STK40.71841309
72EIF2AK20.71412214
73CAMK2D0.71409522
74LATS20.70407297
75LCK0.69254736
76MAP2K40.68859215
77NLK0.65685814
78MARK30.65299010
79BTK0.64981739
80YES10.63401868
81SIK30.62718049
82PRKCE0.62044543
83DAPK10.61815244
84PIM10.61209389
85FGFR30.58522698
86PDGFRB0.57852235
87CAMK2G0.57318782
88MAP2K60.56265824
89CSK0.56106881
90DYRK30.55651011
91BRAF0.55289479
92INSRR0.55272565
93FGR0.54844385
94IRAK20.54840124
95PDK10.53955631
96PRKAA20.53609034
97KSR20.53160811
98IRAK10.52420698
99PRKACG0.51478323
100MAP3K30.50490104
101MARK20.50239446
102FGFR40.49843362
103MAP3K10.49481791
104HIPK20.49052159
105NME10.48853461
106PKN10.48518368
107KIT0.48508257
108CHUK0.48242380
109STK100.47131183
110CAMK2A0.46644090
111FES0.46349821
112PRPF4B0.45636498
113SIK20.45466106
114MELK0.45306120
115TRPM70.45257871
116TAOK20.45064542
117CSF1R0.44631554
118CLK10.44519495
119CAMKK20.44288400
120CAMK1D0.43588633
121KDR0.42700864
122PDGFRA0.42665112
123SGK20.41447913
124MAP2K70.41294409
125SGK30.40983875
126FLT30.40134336
127MST40.38924375
128MAPK70.38871485
129TNK20.38846673
130MAPK120.38469126
131SYK0.38333494
132GRK50.37551383
133CAMK40.36868102
134TIE10.35197284
135MAPK40.35054691
136MATK0.34662406
137PRKAA10.34534478
138WNK30.33398577
139MAP2K10.33390131
140LYN0.33229958
141PRKG20.33143797
142EGFR0.32627153
143TRIB30.32468272
144PRKCZ0.32249403
145PRKCG0.32132186
146TEC0.31025606
147ABL10.30287424
148RPS6KA60.29048738
149PIK3CG0.26911317
150CDK60.24987527
151MAP3K60.22368669
152BMX0.22078471
153ITK0.21919960

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.32921173
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27464730
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.20501637
4Oxidative phosphorylation_Homo sapiens_hsa001902.94595059
5Propanoate metabolism_Homo sapiens_hsa006402.75237018
6Fatty acid degradation_Homo sapiens_hsa000712.47134661
7Parkinsons disease_Homo sapiens_hsa050122.39384877
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33520579
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33209490
10Staphylococcus aureus infection_Homo sapiens_hsa051502.18993327
11Carbon metabolism_Homo sapiens_hsa012002.14491603
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10472233
13Graft-versus-host disease_Homo sapiens_hsa053322.03568725
14Legionellosis_Homo sapiens_hsa051342.01645388
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.87922673
16Fatty acid metabolism_Homo sapiens_hsa012121.83140460
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.80917676
18Alzheimers disease_Homo sapiens_hsa050101.80251871
19Arginine biosynthesis_Homo sapiens_hsa002201.79682464
20Pyruvate metabolism_Homo sapiens_hsa006201.71333816
21Cardiac muscle contraction_Homo sapiens_hsa042601.67526241
22Butanoate metabolism_Homo sapiens_hsa006501.65007758
23Other glycan degradation_Homo sapiens_hsa005111.63758891
24Autoimmune thyroid disease_Homo sapiens_hsa053201.62420541
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.60644437
26Toxoplasmosis_Homo sapiens_hsa051451.59069689
27Rheumatoid arthritis_Homo sapiens_hsa053231.58845993
28* Peroxisome_Homo sapiens_hsa041461.55632827
29PPAR signaling pathway_Homo sapiens_hsa033201.51924299
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49116590
31Type I diabetes mellitus_Homo sapiens_hsa049401.48653537
32Leishmaniasis_Homo sapiens_hsa051401.47948267
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.47803069
34Collecting duct acid secretion_Homo sapiens_hsa049661.45992808
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43219290
36Huntingtons disease_Homo sapiens_hsa050161.39354123
37Proteasome_Homo sapiens_hsa030501.38439235
38beta-Alanine metabolism_Homo sapiens_hsa004101.37302530
39Hepatitis C_Homo sapiens_hsa051601.36157394
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34375975
41Chemokine signaling pathway_Homo sapiens_hsa040621.31260692
42Tryptophan metabolism_Homo sapiens_hsa003801.30796078
43B cell receptor signaling pathway_Homo sapiens_hsa046621.27206726
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26029960
45Hematopoietic cell lineage_Homo sapiens_hsa046401.25481363
46Herpes simplex infection_Homo sapiens_hsa051681.21889136
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21887570
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20056054
49Folate biosynthesis_Homo sapiens_hsa007901.13962223
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13427673
51Fatty acid elongation_Homo sapiens_hsa000621.13299187
52Hepatitis B_Homo sapiens_hsa051611.11888840
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11618266
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09550694
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06637542
56Pertussis_Homo sapiens_hsa051331.05907059
57African trypanosomiasis_Homo sapiens_hsa051431.03931609
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03485571
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02340462
60Phenylalanine metabolism_Homo sapiens_hsa003601.01492308
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.01244092
62Prolactin signaling pathway_Homo sapiens_hsa049171.01126766
63Allograft rejection_Homo sapiens_hsa053300.99950655
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99265463
65Tuberculosis_Homo sapiens_hsa051520.98923294
66Phagosome_Homo sapiens_hsa041450.98882001
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98459707
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.98210068
69Asthma_Homo sapiens_hsa053100.97275177
70Acute myeloid leukemia_Homo sapiens_hsa052210.97254001
71Amoebiasis_Homo sapiens_hsa051460.96886162
72Biosynthesis of amino acids_Homo sapiens_hsa012300.96821984
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96676155
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96204917
75Dorso-ventral axis formation_Homo sapiens_hsa043200.95738939
76T cell receptor signaling pathway_Homo sapiens_hsa046600.93670752
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93453684
78Malaria_Homo sapiens_hsa051440.92652089
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91966211
80Antigen processing and presentation_Homo sapiens_hsa046120.91647198
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91638897
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90668195
83Complement and coagulation cascades_Homo sapiens_hsa046100.89236005
84Starch and sucrose metabolism_Homo sapiens_hsa005000.85697020
85Viral myocarditis_Homo sapiens_hsa054160.85195549
86Apoptosis_Homo sapiens_hsa042100.81194850
87Salmonella infection_Homo sapiens_hsa051320.79838236
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79042210
89Bladder cancer_Homo sapiens_hsa052190.75732021
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74243956
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.73956389
92Sulfur relay system_Homo sapiens_hsa041220.73546179
93Fructose and mannose metabolism_Homo sapiens_hsa000510.72406134
94Sulfur metabolism_Homo sapiens_hsa009200.72227289
95VEGF signaling pathway_Homo sapiens_hsa043700.72028575
96Prion diseases_Homo sapiens_hsa050200.71994620
97Shigellosis_Homo sapiens_hsa051310.70510059
98TNF signaling pathway_Homo sapiens_hsa046680.69372780
99Sphingolipid metabolism_Homo sapiens_hsa006000.69136086
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.68623786
101Caffeine metabolism_Homo sapiens_hsa002320.66763924
102Influenza A_Homo sapiens_hsa051640.63309522
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60312703
104Primary immunodeficiency_Homo sapiens_hsa053400.59647197
105Pentose phosphate pathway_Homo sapiens_hsa000300.59457504
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.58619471
107Lysosome_Homo sapiens_hsa041420.58274629
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57091205
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.56027335
110Osteoclast differentiation_Homo sapiens_hsa043800.55095506
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54289950
112Galactose metabolism_Homo sapiens_hsa000520.54079322
113Arginine and proline metabolism_Homo sapiens_hsa003300.53092858
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52440522
115Synaptic vesicle cycle_Homo sapiens_hsa047210.52034112
116Dilated cardiomyopathy_Homo sapiens_hsa054140.51760342
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51742363
118Epstein-Barr virus infection_Homo sapiens_hsa051690.50362563
119Fatty acid biosynthesis_Homo sapiens_hsa000610.49307894
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.48491448
121Tyrosine metabolism_Homo sapiens_hsa003500.47651157
122* FoxO signaling pathway_Homo sapiens_hsa040680.46774518
123Pancreatic cancer_Homo sapiens_hsa052120.46558350
124Insulin resistance_Homo sapiens_hsa049310.46185686
125Metabolic pathways_Homo sapiens_hsa011000.45972665
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45489290
127Selenocompound metabolism_Homo sapiens_hsa004500.45312259
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45220932
129Chronic myeloid leukemia_Homo sapiens_hsa052200.43931998
130Regulation of autophagy_Homo sapiens_hsa041400.43367202
131Chemical carcinogenesis_Homo sapiens_hsa052040.42808535
132Measles_Homo sapiens_hsa051620.42555633
133MAPK signaling pathway_Homo sapiens_hsa040100.41971151
134Platelet activation_Homo sapiens_hsa046110.41850524
135HIF-1 signaling pathway_Homo sapiens_hsa040660.41406833
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41371257
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40891484
138Mineral absorption_Homo sapiens_hsa049780.40150040
139Vibrio cholerae infection_Homo sapiens_hsa051100.39678291
140Histidine metabolism_Homo sapiens_hsa003400.39669188
141Nitrogen metabolism_Homo sapiens_hsa009100.39398403
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39089567
143Glutathione metabolism_Homo sapiens_hsa004800.39051720
144Renal cell carcinoma_Homo sapiens_hsa052110.36905469
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.36363879
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35977538
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35850607
148Notch signaling pathway_Homo sapiens_hsa043300.35827575
149ABC transporters_Homo sapiens_hsa020100.34904027
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.34850810
151Type II diabetes mellitus_Homo sapiens_hsa049300.34558455
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30438712
153Glycerolipid metabolism_Homo sapiens_hsa005610.28883681
154GnRH signaling pathway_Homo sapiens_hsa049120.28422765
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28377637
156HTLV-I infection_Homo sapiens_hsa051660.27445350
157mTOR signaling pathway_Homo sapiens_hsa041500.27219429
158ErbB signaling pathway_Homo sapiens_hsa040120.21585587
159Viral carcinogenesis_Homo sapiens_hsa052030.21337199
160Ovarian steroidogenesis_Homo sapiens_hsa049130.18934133
161Prostate cancer_Homo sapiens_hsa052150.17785891

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