SOCS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.69829676
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.40511062
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.40511062
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.40511062
5modulation by symbiont of host immune response (GO:0052553)5.40511062
6positive regulation by symbiont of host defense response (GO:0052509)5.40511062
7modulation by symbiont of host defense response (GO:0052031)5.40511062
8regulation of fever generation (GO:0031620)4.76502430
9regulation of T-helper 1 cell differentiation (GO:0045625)4.75454484
10regulation of chronic inflammatory response (GO:0002676)4.51209447
11regulation of vitamin metabolic process (GO:0030656)4.48861916
12response to muramyl dipeptide (GO:0032495)4.33967638
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33277081
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.33277081
15macrophage activation involved in immune response (GO:0002281)4.31396640
16antigen processing and presentation of endogenous antigen (GO:0019883)4.12880590
17regulation of cytokine secretion involved in immune response (GO:0002739)4.11288281
18response to peptidoglycan (GO:0032494)4.04633203
19regulation of chemokine biosynthetic process (GO:0045073)3.97231903
20T-helper 1 type immune response (GO:0042088)3.83749446
21negative regulation of cytokine production involved in immune response (GO:0002719)3.69472748
22positive regulation of gamma-delta T cell activation (GO:0046645)3.68950563
23regulation of heat generation (GO:0031650)3.67688152
24regulation of T-helper 2 cell differentiation (GO:0045628)3.67391041
25microglial cell activation (GO:0001774)3.64149941
26NIK/NF-kappaB signaling (GO:0038061)3.59558403
27negative regulation of interleukin-12 production (GO:0032695)3.58359361
28defense response to protozoan (GO:0042832)3.56001206
29response to protozoan (GO:0001562)3.55072692
30immunoglobulin mediated immune response (GO:0016064)3.51751802
31positive regulation of interferon-alpha production (GO:0032727)3.50781198
32positive regulation of type 2 immune response (GO:0002830)3.46649295
33positive regulation of nitric oxide biosynthetic process (GO:0045429)3.41821756
34regulation of interferon-alpha production (GO:0032647)3.41601887
35regulation of interferon-beta biosynthetic process (GO:0045357)3.40992828
36positive regulation of acute inflammatory response (GO:0002675)3.40054177
37positive regulation of NF-kappaB import into nucleus (GO:0042346)3.38938069
38regulation of nitric oxide biosynthetic process (GO:0045428)3.38703239
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38067270
40positive regulation of p38MAPK cascade (GO:1900745)3.35992946
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35586334
42negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.34014528
43negative regulation of nitric oxide biosynthetic process (GO:0045019)3.33832496
44regulation of mononuclear cell migration (GO:0071675)3.32587436
45response to host immune response (GO:0052572)3.26538440
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26538440
47positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.22757556
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.21905830
49regulation of heterotypic cell-cell adhesion (GO:0034114)3.17849236
50regulation of integrin activation (GO:0033623)3.16640704
51positive regulation of interferon-beta production (GO:0032728)3.16402194
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16220502
53macrophage activation (GO:0042116)3.12297460
54cellular response to lipopolysaccharide (GO:0071222)3.11657360
55activation of MAPKKK activity (GO:0000185)3.11616697
56regulation of T-helper cell differentiation (GO:0045622)3.10126622
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.09231417
58response to host (GO:0075136)3.09231417
59response to host defenses (GO:0052200)3.09231417
60regulation of gamma-delta T cell activation (GO:0046643)3.09028691
61regulation of type 2 immune response (GO:0002828)3.07348806
62regulation of immunoglobulin secretion (GO:0051023)3.05521304
63cellular response to molecule of bacterial origin (GO:0071219)3.03603644
64positive regulation of chemokine biosynthetic process (GO:0045080)3.03187965
65negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.02592099
66negative regulation of production of molecular mediator of immune response (GO:0002701)3.01934289
67lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00708964
68neutrophil activation involved in immune response (GO:0002283)3.00683593
69positive regulation of antigen processing and presentation (GO:0002579)3.00450716
70regulation of NF-kappaB import into nucleus (GO:0042345)2.99471332
71* response to type I interferon (GO:0034340)2.98814075
72* cellular response to type I interferon (GO:0071357)2.96701283
73* type I interferon signaling pathway (GO:0060337)2.96701283
74response to laminar fluid shear stress (GO:0034616)2.94355436
75apoptotic cell clearance (GO:0043277)2.92631776
76cell adhesion mediated by integrin (GO:0033627)2.91304231
77regulation of podosome assembly (GO:0071801)2.91229621
78regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90679585
79positive regulation of interleukin-6 production (GO:0032755)2.88291288
80low-density lipoprotein particle clearance (GO:0034383)2.85911439
81positive regulation of T-helper cell differentiation (GO:0045624)2.84244077
82regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.83174893
83tolerance induction (GO:0002507)2.83162115
84monocyte chemotaxis (GO:0002548)2.81334160
85germinal center formation (GO:0002467)2.80979082
86* JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.79928246
87positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.78486153
88granulocyte activation (GO:0036230)2.78383829
89detection of molecule of bacterial origin (GO:0032490)2.77402530
90negative regulation of growth of symbiont in host (GO:0044130)2.77365870
91negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.77365870
92modulation of growth of symbiont involved in interaction with host (GO:0044144)2.77365870
93regulation of growth of symbiont in host (GO:0044126)2.77365870
94positive regulation of natural killer cell differentiation (GO:0032825)2.76706548
95myeloid dendritic cell activation (GO:0001773)2.76494062
96regulation of gamma-delta T cell differentiation (GO:0045586)2.74765748
97regulation of cholesterol storage (GO:0010885)2.74517222
98leukocyte cell-cell adhesion (GO:0007159)2.73492930
99modulation by symbiont of host cellular process (GO:0044068)2.72973689
100positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.72956169
101negative regulation of interleukin-6 production (GO:0032715)2.70505721
102regulation of interleukin-6 production (GO:0032675)2.69834130
103virion attachment to host cell (GO:0019062)2.69683228
104adhesion of symbiont to host cell (GO:0044650)2.69683228
105positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69589880
106* interferon-gamma-mediated signaling pathway (GO:0060333)2.68273187
107cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.67135341
108positive regulation of transcription factor import into nucleus (GO:0042993)2.66601783
109detection of other organism (GO:0098543)2.65912223
110establishment of endothelial barrier (GO:0061028)2.65841532
111cellular response to biotic stimulus (GO:0071216)2.64399533
112negative regulation of cell killing (GO:0031342)2.64169620
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64169620
114B cell mediated immunity (GO:0019724)2.63849096
115negative regulation of stress fiber assembly (GO:0051497)2.63840979
116Notch signaling involved in heart development (GO:0061314)2.62684391
117I-kappaB phosphorylation (GO:0007252)2.62579506
118vascular endothelial growth factor signaling pathway (GO:0038084)2.61836092
119adhesion of symbiont to host (GO:0044406)2.61554200
120mature B cell differentiation involved in immune response (GO:0002313)2.60554110
121negative regulation of toll-like receptor signaling pathway (GO:0034122)2.60339477
122cellular extravasation (GO:0045123)2.58915023
123negative regulation of amino acid transport (GO:0051956)2.58592052
124positive regulation of chemokine production (GO:0032722)2.58141798
125cytokine secretion (GO:0050663)2.56873263
126positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53300787
127negative regulation of lipid storage (GO:0010888)2.52675524
128endothelial tube morphogenesis (GO:0061154)2.52545610
129morphogenesis of an endothelium (GO:0003159)2.52545610
130positive thymic T cell selection (GO:0045059)2.51354117
131positive regulation of heat generation (GO:0031652)2.50706668
132regulation of antigen processing and presentation (GO:0002577)2.50569678
133endothelial cell chemotaxis (GO:0035767)2.50130727
134myeloid dendritic cell differentiation (GO:0043011)2.46912666
135regulation of membrane protein ectodomain proteolysis (GO:0051043)2.46689270
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.46632309
137leukocyte tethering or rolling (GO:0050901)2.46589191
138regulation of toll-like receptor signaling pathway (GO:0034121)2.45851430
139regulation of interleukin-12 production (GO:0032655)2.44816405
140positive regulation of cellular amide metabolic process (GO:0034250)2.44768140
141* regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44457482
142positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44439869
143regulation of interleukin-8 biosynthetic process (GO:0045414)2.43382695
144wound healing, spreading of epidermal cells (GO:0035313)2.42748864
145response to interferon-alpha (GO:0035455)2.42727265
146regulation of p38MAPK cascade (GO:1900744)2.41824441
147positive regulation of interleukin-12 production (GO:0032735)2.40386932
148leukocyte aggregation (GO:0070486)2.40153540
149regulation of interferon-beta production (GO:0032648)2.39739790
150positive regulation of toll-like receptor signaling pathway (GO:0034123)2.39598784
151regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39357260
152positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.38671752
153positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37867698
154myeloid cell activation involved in immune response (GO:0002275)2.37333655
155regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.36984020

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.12010473
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.32550479
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.30878047
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.08237528
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.81444955
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.48461096
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00112213
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.91419677
9* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.83737489
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77171701
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.66855753
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65847374
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46132931
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41700346
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33276743
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14791785
17CLOCK_20551151_ChIP-Seq_293T_Human2.12529075
18* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09229233
19* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09229233
20* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09229233
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.09218244
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07506903
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05418087
24* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00926810
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93759888
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90008322
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.89319575
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.88852177
29* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87063355
30MYC_22102868_ChIP-Seq_BL_Human1.86798263
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78491228
32MAF_26560356_Chip-Seq_TH1_Human1.77165418
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76658095
34* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76005806
35* TCF7_22412390_ChIP-Seq_EML_Mouse1.74561188
36RUNX_20019798_ChIP-Seq_JUKART_Human1.71446870
37VDR_21846776_ChIP-Seq_THP-1_Human1.68968751
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62699368
39* ESR2_21235772_ChIP-Seq_MCF-7_Human1.60761011
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60179327
41* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59041506
42VDR_24763502_ChIP-Seq_THP-1_Human1.54285235
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53331130
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51844999
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51819440
46* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50981523
47* KDM2B_26808549_Chip-Seq_DND41_Human1.49635685
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49278290
49MYB_26560356_Chip-Seq_TH2_Human1.47288391
50* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46378962
51GATA1_22025678_ChIP-Seq_K562_Human1.43926227
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42945850
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42814639
54* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42599814
55* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41314363
56* MYB_26560356_Chip-Seq_TH1_Human1.39433292
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.39387741
58* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38980423
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35622422
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34928457
61UTX_26944678_Chip-Seq_JUKART_Human1.33436121
62* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31979874
63* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30157027
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.27641612
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27367334
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27337804
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.26901495
68SCL_19346495_ChIP-Seq_HPC-7_Human1.26438674
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.25756549
70SPI1_23547873_ChIP-Seq_NB4_Human1.24763005
71* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24671133
72SPI1_23127762_ChIP-Seq_K562_Human1.24541982
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18606678
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18606678
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.18297415
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17714719
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16345437
78* RACK7_27058665_Chip-Seq_MCF-7_Human1.13135087
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10991049
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10239414
81PU_27001747_Chip-Seq_BMDM_Mouse1.10171655
82ATF3_27146783_Chip-Seq_COLON_Human1.09051194
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08938933
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.08030260
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.07757422
86NCOR1_26117541_ChIP-Seq_K562_Human1.07642806
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07319779
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07144173
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06511339
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06435845
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06273436
92* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06120177
93VDR_24787735_ChIP-Seq_THP-1_Human1.06107204
94* KDM2B_26808549_Chip-Seq_K562_Human1.04956207
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04778099
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04396875
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02969916
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01918848
99* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01776031
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01252266
101EGR1_19032775_ChIP-ChIP_M12_Human1.00522226
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00464296
103MAF_26560356_Chip-Seq_TH2_Human1.00165520
104* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99537993
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.99073980
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97548680
107ZNF263_19887448_ChIP-Seq_K562_Human0.95597277
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95363805
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94128587
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.93358309
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93138587
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92998534
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91793103
114LXR_22292898_ChIP-Seq_THP-1_Human0.91567006
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91531035
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91047420
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90039653
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89974617
119* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89641839
120GATA3_27048872_Chip-Seq_THYMUS_Human0.89358576
121GATA1_19941826_ChIP-Seq_K562_Human0.89039494
122* RXR_22158963_ChIP-Seq_LIVER_Mouse0.84643420
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84228847
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83352837
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82823165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to2.83105508
2* MP0003724_increased_susceptibility_to2.59253326
3MP0003300_gastrointestinal_ulcer2.48056683
4MP0004510_myositis2.41403695
5MP0002254_reproductive_system_inflammat2.37083550
6MP0009785_altered_susceptibility_to2.36315429
7MP0001835_abnormal_antigen_presentation2.33167123
8MP0004947_skin_inflammation2.27152171
9* MP0003303_peritoneal_inflammation2.24237039
10MP0001790_abnormal_immune_system2.22296129
11MP0005387_immune_system_phenotype2.22296129
12MP0000685_abnormal_immune_system2.19254335
13MP0006082_CNS_inflammation2.17668530
14* MP0005000_abnormal_immune_tolerance2.13921290
15MP0002419_abnormal_innate_immunity2.11488829
16MP0005076_abnormal_cell_differentiation2.08404986
17MP0005451_abnormal_body_composition2.00672251
18MP0002332_abnormal_exercise_endurance2.00454262
19MP0001851_eye_inflammation1.98834405
20MP0003705_abnormal_hypodermis_morpholog1.97385246
21MP0003828_pulmonary_edema1.97317108
22MP0005025_abnormal_response_to1.96420132
23MP0001800_abnormal_humoral_immune1.94554799
24* MP0009278_abnormal_bone_marrow1.94446382
25MP0010352_gastrointestinal_tract_polyps1.94339304
26MP0003448_altered_tumor_morphology1.94156495
27MP0003566_abnormal_cell_adhesion1.93675200
28MP0002148_abnormal_hypersensitivity_rea1.90738815
29MP0005023_abnormal_wound_healing1.89911416
30* MP0001533_abnormal_skeleton_physiology1.89500866
31MP0002452_abnormal_antigen_presenting1.89333754
32MP0009840_abnormal_foam_cell1.85911998
33* MP0002723_abnormal_immune_serum1.83134930
34MP0008438_abnormal_cutaneous_collagen1.80974587
35MP0003453_abnormal_keratinocyte_physiol1.78785408
36MP0000343_altered_response_to1.74672820
37MP0005257_abnormal_intraocular_pressure1.74085380
38MP0005671_abnormal_response_to1.67008062
39MP0010155_abnormal_intestine_physiology1.64319241
40* MP0002405_respiratory_system_inflammati1.60946437
41MP0005167_abnormal_blood-brain_barrier1.60153012
42MP0006054_spinal_hemorrhage1.60142944
43MP0001819_abnormal_immune_cell1.58225334
44MP0010307_abnormal_tumor_latency1.57425110
45MP0002420_abnormal_adaptive_immunity1.56816563
46MP0001853_heart_inflammation1.50912683
47MP0003075_altered_response_to1.46633025
48MP0002139_abnormal_hepatobiliary_system1.43781240
49* MP0001845_abnormal_inflammatory_respons1.41256580
50MP0005464_abnormal_platelet_physiology1.39899808
51MP0003690_abnormal_glial_cell1.39870750
52MP0010368_abnormal_lymphatic_system1.38512732
53MP0002166_altered_tumor_susceptibility1.36093248
54MP0002006_tumorigenesis1.34828370
55MP0003091_abnormal_cell_migration1.34528811
56MP0005275_abnormal_skin_tensile1.34173141
57MP0000858_altered_metastatic_potential1.33739320
58MP0003191_abnormal_cellular_cholesterol1.32490101
59MP0009333_abnormal_splenocyte_physiolog1.32376449
60MP0005058_abnormal_lysosome_morphology1.30416543
61MP0004272_abnormal_basement_membrane1.29949910
62MP0003763_abnormal_thymus_physiology1.28710845
63* MP0001545_abnormal_hematopoietic_system1.27440922
64* MP0005397_hematopoietic_system_phenotyp1.27440922
65MP0002998_abnormal_bone_remodeling1.25863492
66* MP0005390_skeleton_phenotype1.25760226
67MP0002933_joint_inflammation1.23649995
68MP0008469_abnormal_protein_level1.21138330
69MP0002398_abnormal_bone_marrow1.20181609
70* MP0000716_abnormal_immune_system1.17836314
71MP0000767_abnormal_smooth_muscle1.17808641
72MP0001501_abnormal_sleep_pattern1.14298410
73MP0003279_aneurysm1.13533390
74MP0009764_decreased_sensitivity_to1.08924196
75MP0005164_abnormal_response_to1.08923792
76MP0000465_gastrointestinal_hemorrhage1.08876482
77MP0001879_abnormal_lymphatic_vessel1.08565032
78MP0004858_abnormal_nervous_system1.07637886
79MP0001849_ear_inflammation1.04843145
80MP0003656_abnormal_erythrocyte_physiolo1.04054642
81* MP0000689_abnormal_spleen_morphology1.03548451
82* MP0002722_abnormal_immune_system1.02777145
83MP0005165_increased_susceptibility_to1.01816655
84MP0001958_emphysema1.01581200
85MP0002060_abnormal_skin_morphology1.01036042
86* MP0002429_abnormal_blood_cell0.98782741
87MP0003195_calcinosis0.97897718
88MP0000249_abnormal_blood_vessel0.97247372
89MP0002877_abnormal_melanocyte_morpholog0.96084267
90MP0000733_abnormal_muscle_development0.95639998
91MP0003045_fibrosis0.94052711
92MP0005166_decreased_susceptibility_to0.93073973
93MP0002277_abnormal_respiratory_mucosa0.92101933
94MP0001873_stomach_inflammation0.92038571
95* MP0004808_abnormal_hematopoietic_stem0.88858929
96MP0005310_abnormal_salivary_gland0.88780261
97MP0009765_abnormal_xenobiotic_induced0.88650054
98MP0005666_abnormal_adipose_tissue0.88603515
99MP0002396_abnormal_hematopoietic_system0.83215753
100MP0000703_abnormal_thymus_morphology0.82955091
101MP0004883_abnormal_blood_vessel0.82745862
102MP0005535_abnormal_body_temperature0.82613129
103MP0001915_intracranial_hemorrhage0.81466446
104MP0001216_abnormal_epidermal_layer0.81376529
105MP0000604_amyloidosis0.81134046
106MP0009763_increased_sensitivity_to0.81031872
107MP0002138_abnormal_hepatobiliary_system0.79701101
108MP0003172_abnormal_lysosome_physiology0.79135209
109MP0008004_abnormal_stomach_pH0.77676179
110MP0005595_abnormal_vascular_smooth0.76538735
111MP0001542_abnormal_bone_strength0.75760352
112MP0005647_abnormal_sex_gland0.75709811
113MP0005508_abnormal_skeleton_morphology0.74826287
114MP0000750_abnormal_muscle_regeneration0.74784201
115MP0008874_decreased_physiological_sensi0.72356459
116MP0003795_abnormal_bone_structure0.71531344
117MP0000920_abnormal_myelination0.67420155
118* MP0001663_abnormal_digestive_system0.63218478
119MP0003329_amyloid_beta_deposits0.62487875
120MP0003806_abnormal_nucleotide_metabolis0.60004292
121MP0005375_adipose_tissue_phenotype0.57601037
122MP0008260_abnormal_autophagy0.57570026
123MP0003646_muscle_fatigue0.57533485

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.70662631
2Elevated erythrocyte sedimentation rate (HP:0003565)4.20381946
3Orchitis (HP:0100796)3.98906676
4Systemic lupus erythematosus (HP:0002725)3.90883617
5Myositis (HP:0100614)3.90666846
6Loss of speech (HP:0002371)3.84670732
7Recurrent abscess formation (HP:0002722)3.75519726
8Hematochezia (HP:0002573)3.72675633
9Cerebral aneurysm (HP:0004944)3.46142000
10Disinhibition (HP:0000734)3.40149118
11Recurrent bacterial skin infections (HP:0005406)3.26785917
12Nuclear cataract (HP:0100018)3.24992817
13Retrobulbar optic neuritis (HP:0100654)3.22037358
14Optic neuritis (HP:0100653)3.22037358
15Stomatitis (HP:0010280)3.19853776
16Recurrent gram-negative bacterial infections (HP:0005420)3.07112048
17Pustule (HP:0200039)3.04460871
18Abnormality of polysaccharide metabolism (HP:0011012)3.01662713
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.01662713
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01662713
21Mediastinal lymphadenopathy (HP:0100721)3.01006187
22Gangrene (HP:0100758)2.98628684
23Abnormality of the nasal mucosa (HP:0000433)2.94619105
24Myocardial infarction (HP:0001658)2.91451561
25Abnormality of macrophages (HP:0004311)2.91082067
26Neurofibrillary tangles (HP:0002185)2.89107530
27Interstitial pulmonary disease (HP:0006530)2.88488971
28Urinary glycosaminoglycan excretion (HP:0003541)2.86396284
29Mucopolysacchariduria (HP:0008155)2.86396284
30Thick nail (HP:0001805)2.82495887
31Glomerulonephritis (HP:0000099)2.78728253
32Mutism (HP:0002300)2.78455952
33Increased IgM level (HP:0003496)2.77450619
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.76957861
35Osteolytic defects of the hand bones (HP:0009699)2.76957861
36Autoimmune thrombocytopenia (HP:0001973)2.73112084
37Spontaneous hematomas (HP:0007420)2.72119428
38Prostate neoplasm (HP:0100787)2.63929877
39Increased cerebral lipofuscin (HP:0011813)2.63236632
40Increased serum ferritin (HP:0003281)2.61207218
41Peritonitis (HP:0002586)2.60962577
42Chronic otitis media (HP:0000389)2.58814465
43Gingivitis (HP:0000230)2.51938614
44Premature rupture of membranes (HP:0001788)2.49292626
45Recurrent fungal infections (HP:0002841)2.48586020
46Esophageal varix (HP:0002040)2.46162534
47Polycythemia (HP:0001901)2.45463071
48Nasal polyposis (HP:0100582)2.44832451
49Abnormality of the pleura (HP:0002103)2.44238558
50Vasculitis (HP:0002633)2.42276379
51Hypergammaglobulinemia (HP:0010702)2.41273769
52Increased connective tissue (HP:0009025)2.40912536
53Arterial thrombosis (HP:0004420)2.39674244
54Parakeratosis (HP:0001036)2.34292762
55Autoimmune hemolytic anemia (HP:0001890)2.31569247
56Keratoconjunctivitis sicca (HP:0001097)2.29703148
57Polyneuropathy (HP:0001271)2.29648918
58Episodic fever (HP:0001954)2.28259251
59Pulmonary infiltrates (HP:0002113)2.26342287
60Cellulitis (HP:0100658)2.25600565
61Axonal loss (HP:0003447)2.24774730
62Joint swelling (HP:0001386)2.24256902
63Aortic aneurysm (HP:0004942)2.22694022
64Tetraparesis (HP:0002273)2.21448944
65Leukocytosis (HP:0001974)2.21401687
66Apathy (HP:0000741)2.21278899
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.20745467
68Milia (HP:0001056)2.19781573
69Emphysema (HP:0002097)2.19564263
70Encephalitis (HP:0002383)2.19266915
71Ankle contracture (HP:0006466)2.19186414
72Acne (HP:0001061)2.18575525
73Nephritis (HP:0000123)2.18332715
74Vertigo (HP:0002321)2.17720326
75Increased IgE level (HP:0003212)2.17475653
76Amyloidosis (HP:0011034)2.16836780
77Pulmonary embolism (HP:0002204)2.14768163
78Keratoconjunctivitis (HP:0001096)2.13729682
79Urethral obstruction (HP:0000796)2.12886325
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.12187757
81Porencephaly (HP:0002132)2.11054340
82Dilatation of the ascending aorta (HP:0005111)2.10991460
83T lymphocytopenia (HP:0005403)2.08959298
84Progressive neurologic deterioration (HP:0002344)2.08517396
85Meningitis (HP:0001287)2.08409767
86Diminished motivation (HP:0000745)2.08218902
87Asymmetric septal hypertrophy (HP:0001670)2.07813871
88Abnormality of liposaccharide metabolism (HP:0010968)2.07427725
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.07427725
90Abnormality of glycolipid metabolism (HP:0010969)2.07427725
91Glomerulopathy (HP:0100820)2.07119477
92Abnormality of complement system (HP:0005339)2.05629601
93Purpura (HP:0000979)2.04864868
94Cerebral inclusion bodies (HP:0100314)2.04423613
95Malnutrition (HP:0004395)2.04095975
96Abnormality of iron homeostasis (HP:0011031)2.02893314
97Protrusio acetabuli (HP:0003179)2.00612373
98Aortic dissection (HP:0002647)2.00596962
99Thin bony cortex (HP:0002753)2.00273592
100Recurrent skin infections (HP:0001581)2.00013145
101Periodontitis (HP:0000704)2.00010044
102Shallow orbits (HP:0000586)1.99747734
103Abnormality of the distal phalanges of the toes (HP:0010182)1.99481107
104Recurrent viral infections (HP:0004429)1.98534648
105Keratitis (HP:0000491)1.97567466
106Complement deficiency (HP:0004431)1.97212321
107Alopecia of scalp (HP:0002293)1.96908142
108Abnormality of T cell number (HP:0011839)1.96659146
109Persistence of primary teeth (HP:0006335)1.96522953
110Arterial tortuosity (HP:0005116)1.96468508
111Neuronal loss in central nervous system (HP:0002529)1.96452098
112Arthralgia (HP:0002829)1.96242476
113Abnormality of the endocardium (HP:0004306)1.94459302
114Hemoptysis (HP:0002105)1.93876043
115Mitral valve prolapse (HP:0001634)1.92695573
116Vertebral compression fractures (HP:0002953)1.91426924
117Adactyly (HP:0009776)1.88026636
118Vascular tortuosity (HP:0004948)1.87977188
119Nausea (HP:0002018)1.87381159
120Premature loss of primary teeth (HP:0006323)1.86198064
121Hepatosplenomegaly (HP:0001433)1.86027290
122Thoracolumbar scoliosis (HP:0002944)1.84811332
123Atrophic scars (HP:0001075)1.84119747
124Ulnar bowing (HP:0003031)1.83629113
125Peripheral demyelination (HP:0011096)1.83251087
126Obstructive lung disease (HP:0006536)1.82795894
127Chronic obstructive pulmonary disease (HP:0006510)1.82795894
128Gastrointestinal infarctions (HP:0005244)1.82355723
129Urticaria (HP:0001025)1.80231719
130Inappropriate behavior (HP:0000719)1.79820079
131Skin ulcer (HP:0200042)1.79540594
132Colitis (HP:0002583)1.78682537
133Striae distensae (HP:0001065)1.78070584
134Pulmonary artery stenosis (HP:0004415)1.77946480
135Eosinophilia (HP:0001880)1.77342595
136Stomach cancer (HP:0012126)1.76385787
137Dysostosis multiplex (HP:0000943)1.75610041
138Segmental peripheral demyelination/remyelination (HP:0003481)1.75529557
139Vacuolated lymphocytes (HP:0001922)1.75511990
140Increased density of long bones (HP:0006392)1.75327516
141Conjunctival telangiectasia (HP:0000524)1.75264186
142Abnormality of the peritoneum (HP:0002585)1.74988781
143Short nail (HP:0001799)1.74450111
144Aneurysm (HP:0002617)1.73868998
145Abnormality of the pericardium (HP:0001697)1.69999072
146Basal ganglia calcification (HP:0002135)1.68408061
147Cervical subluxation (HP:0003308)1.67298493
148Anorexia (HP:0002039)1.65561152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.23718169
2TGFBR23.19184074
3TYK23.02939916
4GRK72.93365468
5TAOK22.85438391
6MAPK152.83856962
7EPHB12.78479320
8MAP3K142.77873770
9TBK12.73325463
10PRPF4B2.49907181
11FGFR42.40382239
12MAP4K12.23198025
13EPHA32.18298724
14KDR2.18068452
15MAP3K32.17033093
16IRAK32.16847617
17JAK32.08307791
18JAK12.06064085
19TIE12.05167613
20IKBKE2.04527689
21STK102.01149852
22RIPK12.00954460
23IKBKB1.95390240
24BLK1.73316344
25BMPR21.70846854
26CDC42BPA1.68183984
27CSK1.67753778
28RPS6KA41.60424216
29TSSK61.60009469
30CHUK1.48557370
31TRIB31.43225127
32MAP3K101.42624926
33TXK1.42455450
34PTK61.40168715
35IRAK21.38062763
36FGFR31.37553785
37MAP2K31.34201122
38ZAP701.32401754
39CDK121.23597798
40EPHA21.22627421
41MARK31.15815676
42PIM11.15190390
43PIM21.09658629
44KIT1.09237507
45RIPK41.06469890
46MAP2K21.05084986
47PKN21.03350668
48HCK1.03307717
49PAK41.00670987
50IRAK40.99808807
51BMX0.94055385
52ITK0.93854667
53NLK0.93814879
54LATS20.93361731
55CSF1R0.93284063
56GSK3A0.92860151
57TTN0.91067455
58ADRBK20.89501673
59* JAK20.87277995
60MAP3K130.83820854
61TYRO30.80861298
62STK30.80793970
63TGFBR10.80036510
64MAPK70.78496040
65ABL20.77930973
66FGR0.76143082
67LRRK20.75098254
68SYK0.73831726
69ALK0.73596315
70MAP3K110.72371372
71CDK60.70855036
72PAK20.69546936
73SIK30.68620408
74PDGFRA0.67103283
75BTK0.66072626
76PDGFRB0.65577012
77* LCK0.65223337
78SIK10.64617615
79NME20.64519354
80TAOK10.63954606
81TAOK30.62571598
82MST40.62504113
83MAPKAPK20.62267195
84ICK0.60830923
85MATK0.59066725
86PTK20.57567439
87IRAK10.55958904
88MTOR0.54143068
89PRKG20.54115894
90FES0.52918381
91RPS6KL10.52533744
92RPS6KC10.52533744
93EGFR0.52430801
94MAP3K10.52042980
95GRK60.51854607
96MAP3K80.50532788
97PDK20.48990647
98ACVR1B0.48908847
99MOS0.47516584
100ERBB40.47452350
101MAP2K60.46606422
102MARK20.46313134
103RPS6KA50.46101519
104ABL10.45439277
105CDK40.45183859
106EEF2K0.44500075
107HIPK20.43685444
108TEC0.43426011
109PKN10.40797766
110MAP3K50.40574886
111LATS10.40118716
112RPS6KB20.39374043
113DMPK0.38227867
114MAPK40.37719941
115NEK20.36775506
116DYRK30.36582048
117LYN0.36257472
118CLK10.35274888
119DDR20.34481745
120PRKAA20.34117067
121PDK10.34111424
122PDPK10.34062824
123MAPKAPK30.32749516
124MAP3K60.32020410
125DYRK1B0.31991152
126RPS6KA60.31432712
127MELK0.31123983
128FER0.30287707
129RPS6KA20.28228362
130TNK20.27947566
131DAPK20.27713610
132MAPK30.24979106
133RPS6KA10.22156087
134FYN0.21221485

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.85135884
2Staphylococcus aureus infection_Homo sapiens_hsa051502.52907056
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.49278972
4Malaria_Homo sapiens_hsa051442.46900116
5* Osteoclast differentiation_Homo sapiens_hsa043802.45464305
6Legionellosis_Homo sapiens_hsa051342.12987031
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12490385
8* TNF signaling pathway_Homo sapiens_hsa046682.10128684
9Toxoplasmosis_Homo sapiens_hsa051452.03818616
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02130886
11Measles_Homo sapiens_hsa051622.00842956
12Pertussis_Homo sapiens_hsa051331.94838147
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88036095
14Antigen processing and presentation_Homo sapiens_hsa046121.75211528
15Autoimmune thyroid disease_Homo sapiens_hsa053201.72352552
16* Influenza A_Homo sapiens_hsa051641.68535880
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.68279221
18B cell receptor signaling pathway_Homo sapiens_hsa046621.62661862
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60544273
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55387222
21African trypanosomiasis_Homo sapiens_hsa051431.50451733
22Apoptosis_Homo sapiens_hsa042101.50353357
23Tuberculosis_Homo sapiens_hsa051521.47965588
24Graft-versus-host disease_Homo sapiens_hsa053321.45442486
25* Herpes simplex infection_Homo sapiens_hsa051681.44871657
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42630551
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.38932442
28Small cell lung cancer_Homo sapiens_hsa052221.38759069
29Amoebiasis_Homo sapiens_hsa051461.36792296
30* Jak-STAT signaling pathway_Homo sapiens_hsa046301.36336069
31Hepatitis B_Homo sapiens_hsa051611.31855339
32Hematopoietic cell lineage_Homo sapiens_hsa046401.26981344
33Chronic myeloid leukemia_Homo sapiens_hsa052201.24954338
34Notch signaling pathway_Homo sapiens_hsa043301.24562587
35Acute myeloid leukemia_Homo sapiens_hsa052211.23729689
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23537257
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.23256203
38Rheumatoid arthritis_Homo sapiens_hsa053231.22049971
39Allograft rejection_Homo sapiens_hsa053301.19978992
40Shigellosis_Homo sapiens_hsa051311.19707961
41T cell receptor signaling pathway_Homo sapiens_hsa046601.19600358
42Prion diseases_Homo sapiens_hsa050201.19094684
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.18807520
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18676360
45Salmonella infection_Homo sapiens_hsa051321.16830862
46ECM-receptor interaction_Homo sapiens_hsa045121.15937463
47Asthma_Homo sapiens_hsa053101.13355371
48Lysosome_Homo sapiens_hsa041421.12215029
49* Hepatitis C_Homo sapiens_hsa051601.08286067
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04204482
51Chemokine signaling pathway_Homo sapiens_hsa040621.03063508
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99323351
53Focal adhesion_Homo sapiens_hsa045100.96903080
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96359453
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95245219
56MicroRNAs in cancer_Homo sapiens_hsa052060.93850838
57Epstein-Barr virus infection_Homo sapiens_hsa051690.93084323
58HTLV-I infection_Homo sapiens_hsa051660.92726088
59Pancreatic cancer_Homo sapiens_hsa052120.91913626
60Other glycan degradation_Homo sapiens_hsa005110.91286721
61Proteoglycans in cancer_Homo sapiens_hsa052050.90165765
62Dorso-ventral axis formation_Homo sapiens_hsa043200.88595204
63Adherens junction_Homo sapiens_hsa045200.84993192
64Primary immunodeficiency_Homo sapiens_hsa053400.84656450
65Viral myocarditis_Homo sapiens_hsa054160.84371430
66Viral carcinogenesis_Homo sapiens_hsa052030.83613004
67* Prolactin signaling pathway_Homo sapiens_hsa049170.83568772
68Phagosome_Homo sapiens_hsa041450.79195710
69Renal cell carcinoma_Homo sapiens_hsa052110.77674913
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77112247
71VEGF signaling pathway_Homo sapiens_hsa043700.77106395
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.76370142
73HIF-1 signaling pathway_Homo sapiens_hsa040660.74156581
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73691995
75Complement and coagulation cascades_Homo sapiens_hsa046100.73011622
76p53 signaling pathway_Homo sapiens_hsa041150.67840631
77Platelet activation_Homo sapiens_hsa046110.67191730
78Prostate cancer_Homo sapiens_hsa052150.66320647
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65946927
80* Adipocytokine signaling pathway_Homo sapiens_hsa049200.65896413
81Colorectal cancer_Homo sapiens_hsa052100.65003923
82Caffeine metabolism_Homo sapiens_hsa002320.64268194
83* Insulin resistance_Homo sapiens_hsa049310.59664158
84mTOR signaling pathway_Homo sapiens_hsa041500.59386456
85Pathways in cancer_Homo sapiens_hsa052000.58647181
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58370444
87FoxO signaling pathway_Homo sapiens_hsa040680.57533831
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55477922
89TGF-beta signaling pathway_Homo sapiens_hsa043500.54608045
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54350996
91MAPK signaling pathway_Homo sapiens_hsa040100.53872984
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49931757
93Endocytosis_Homo sapiens_hsa041440.49712642
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49607882
95Bladder cancer_Homo sapiens_hsa052190.49416413
96Sphingolipid metabolism_Homo sapiens_hsa006000.47737698
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47660158
98Type I diabetes mellitus_Homo sapiens_hsa049400.46504676
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46003966
100Rap1 signaling pathway_Homo sapiens_hsa040150.45366253
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.42495428
102* Type II diabetes mellitus_Homo sapiens_hsa049300.40635397
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40562553
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38676342
105Estrogen signaling pathway_Homo sapiens_hsa049150.34727321
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.32848740
107Systemic lupus erythematosus_Homo sapiens_hsa053220.30462917
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27273890
109GnRH signaling pathway_Homo sapiens_hsa049120.27176777
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26924202
111Mineral absorption_Homo sapiens_hsa049780.25472393
112PPAR signaling pathway_Homo sapiens_hsa033200.23035696
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22303847
114ErbB signaling pathway_Homo sapiens_hsa040120.18579972
115Sulfur metabolism_Homo sapiens_hsa009200.18399310

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