SOCS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.55875611
2RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)5.49892272
3NIK/NF-kappaB signaling (GO:0038061)5.28047674
4negative regulation of cell killing (GO:0031342)5.03429936
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.03429936
6myeloid dendritic cell differentiation (GO:0043011)5.01519120
7* growth hormone receptor signaling pathway (GO:0060396)4.90966238
8regulation of interleukin-12 biosynthetic process (GO:0045075)4.84620688
9regulation of T-helper 1 cell differentiation (GO:0045625)4.73622701
10immunoglobulin mediated immune response (GO:0016064)4.69491039
11Rap protein signal transduction (GO:0032486)4.67387912
12myeloid dendritic cell activation (GO:0001773)4.61477755
13negative regulation of B cell apoptotic process (GO:0002903)4.52233801
14positive regulation of natural killer cell differentiation (GO:0032825)4.37918913
15neutrophil activation involved in immune response (GO:0002283)4.26113562
16positive regulation of protein autophosphorylation (GO:0031954)4.24129911
17* cellular response to growth hormone stimulus (GO:0071378)4.19972973
18T-helper 1 type immune response (GO:0042088)4.16783203
19regulation of B cell apoptotic process (GO:0002902)4.13635612
20maturation of 5.8S rRNA (GO:0000460)4.07686008
21neutrophil activation (GO:0042119)4.00191357
22response to prostaglandin E (GO:0034695)3.90587495
23negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.86340587
24positive regulation of interleukin-12 production (GO:0032735)3.85670887
25granulocyte activation (GO:0036230)3.81041288
26dendritic cell differentiation (GO:0097028)3.80055715
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.76914664
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.75769033
29regulation of hypersensitivity (GO:0002883)3.75332778
30aggressive behavior (GO:0002118)3.74989842
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.70025958
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67433826
33monocyte chemotaxis (GO:0002548)3.66915737
34regulation of T cell tolerance induction (GO:0002664)3.66273480
35natural killer cell mediated immunity (GO:0002228)3.65445690
36natural killer cell mediated cytotoxicity (GO:0042267)3.65445690
37negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.63773237
38neural tube formation (GO:0001841)3.63593531
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.61191324
40positive thymic T cell selection (GO:0045059)3.60312574
41tryptophan metabolic process (GO:0006568)3.58617348
42cellular response to virus (GO:0098586)3.57808130
43negative regulation of telomere maintenance (GO:0032205)3.55929029
44regulation of immunoglobulin secretion (GO:0051023)3.54325285
45adenosine receptor signaling pathway (GO:0001973)3.54165217
46superoxide anion generation (GO:0042554)3.50772063
47sequestering of actin monomers (GO:0042989)3.47316929
48indole-containing compound catabolic process (GO:0042436)3.34044507
49indolalkylamine catabolic process (GO:0046218)3.34044507
50tryptophan catabolic process (GO:0006569)3.34044507
51positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.33695422
52mast cell activation involved in immune response (GO:0002279)3.30855797
53mast cell degranulation (GO:0043303)3.30855797
54cellular response to zinc ion (GO:0071294)3.29709761
55piRNA metabolic process (GO:0034587)3.29052632
56CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.28701776
57T-helper cell differentiation (GO:0042093)3.28701776
58ubiquinone biosynthetic process (GO:0006744)3.27166105
59adenosine metabolic process (GO:0046085)3.26760838
60positive regulation of antigen processing and presentation (GO:0002579)3.22889010
61regulation of RIG-I signaling pathway (GO:0039535)3.22726647
62hepatocyte apoptotic process (GO:0097284)3.20861883
63regulation of relaxation of muscle (GO:1901077)3.19630615
64response to prostaglandin (GO:0034694)3.17106814
65S-adenosylmethionine metabolic process (GO:0046500)3.15391885
66regulation of meiosis I (GO:0060631)3.14750041
67response to hyperoxia (GO:0055093)3.14149193
68response to increased oxygen levels (GO:0036296)3.14149193
69interferon-gamma-mediated signaling pathway (GO:0060333)3.13825614
70positive regulation of interleukin-2 production (GO:0032743)3.13281908
71negative regulation of calcium ion transmembrane transport (GO:1903170)3.13133799
72negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.13133799
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12348519
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12348519
75chaperone mediated protein folding requiring cofactor (GO:0051085)3.11215465
76indolalkylamine metabolic process (GO:0006586)3.09966316
77dendritic cell chemotaxis (GO:0002407)3.09820700
78positive regulation of humoral immune response (GO:0002922)3.08985114
79regulation of female receptivity (GO:0045924)3.08364257
80negative regulation of norepinephrine secretion (GO:0010700)3.08321622
81positive regulation of T cell cytokine production (GO:0002726)3.07071286
82regulation of antigen processing and presentation (GO:0002577)3.06021463
83actin nucleation (GO:0045010)3.05703183
84regulation of prostaglandin secretion (GO:0032306)3.03962983
85negative regulation of thymocyte apoptotic process (GO:0070244)3.03368240
86valine metabolic process (GO:0006573)3.01998449
87surfactant homeostasis (GO:0043129)3.00068687
88tyrosine phosphorylation of STAT protein (GO:0007260)2.99672686
89regulation of interleukin-12 production (GO:0032655)2.96196694
90ventricular trabecula myocardium morphogenesis (GO:0003222)2.95953872
91positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94057591
92L-fucose metabolic process (GO:0042354)2.93559083
93L-fucose catabolic process (GO:0042355)2.93559083
94fucose catabolic process (GO:0019317)2.93559083
95negative thymic T cell selection (GO:0045060)2.93384807
96negative regulation of lymphocyte apoptotic process (GO:0070229)2.92628529
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92463163
98water-soluble vitamin biosynthetic process (GO:0042364)2.91276602
99regulation of tolerance induction (GO:0002643)2.90789525
100positive regulation of protein homooligomerization (GO:0032464)2.89194292
101endothelial tube morphogenesis (GO:0061154)2.88602504
102morphogenesis of an endothelium (GO:0003159)2.88602504
103pseudouridine synthesis (GO:0001522)2.87604214
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.87322519
105regulation of T-helper 2 cell differentiation (GO:0045628)2.87296706
106positive regulation of B cell differentiation (GO:0045579)2.87067852
107antigen processing and presentation of endogenous antigen (GO:0019883)2.84924093
108T cell differentiation involved in immune response (GO:0002292)2.84894131
109alpha-beta T cell differentiation involved in immune response (GO:0002293)2.84894131
110alpha-beta T cell activation involved in immune response (GO:0002287)2.84894131
111natural killer cell activation (GO:0030101)2.84282772
112eosinophil chemotaxis (GO:0048245)2.84054218
113T cell activation involved in immune response (GO:0002286)2.83932910
114dendritic cell migration (GO:0036336)2.83451292
115kynurenine metabolic process (GO:0070189)2.82330516
116rRNA catabolic process (GO:0016075)2.81563447
117negative T cell selection (GO:0043383)2.80742232
118response to interleukin-15 (GO:0070672)2.80581944
119regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.80554782
120cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.79343770
121autophagic vacuole fusion (GO:0000046)2.78939438
122organelle membrane fusion (GO:0090174)2.78346115
123type I interferon signaling pathway (GO:0060337)2.75914435
124cellular response to type I interferon (GO:0071357)2.75914435
125ubiquinone metabolic process (GO:0006743)2.75726589
126lysosome localization (GO:0032418)2.74842116
127cell fate commitment involved in formation of primary germ layer (GO:0060795)2.73272283
128positive regulation of vasculogenesis (GO:2001214)2.73126225
129response to type I interferon (GO:0034340)2.72337640
130positive regulation of T-helper cell differentiation (GO:0045624)2.72032605
131regulation of necroptotic process (GO:0060544)2.71939152
132positive regulation of endothelial cell differentiation (GO:0045603)2.71039228
133Notch signaling involved in heart development (GO:0061314)2.70729560
134thrombin receptor signaling pathway (GO:0070493)2.70141144
135negative regulation of necroptotic process (GO:0060546)2.69982956
136lymph node development (GO:0048535)2.69810237
137definitive hemopoiesis (GO:0060216)2.69744489
138regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.69223709
139preassembly of GPI anchor in ER membrane (GO:0016254)2.69059766
140positive regulation of fatty acid transport (GO:2000193)2.68968645
141myoblast migration (GO:0051451)2.68549440
142response to interferon-beta (GO:0035456)2.67431908
143regulation of T-helper cell differentiation (GO:0045622)2.67317261
144positive regulation of T-helper 1 type immune response (GO:0002827)2.67296665
145B cell mediated immunity (GO:0019724)2.66632731
146female mating behavior (GO:0060180)2.66389983
147regulation of protein autophosphorylation (GO:0031952)2.66374882
148quinone biosynthetic process (GO:1901663)2.63320810
149G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.62804855
150behavioral response to nicotine (GO:0035095)2.62631970
151positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.62520062
152cellular response to interleukin-15 (GO:0071350)2.61838494
153branched-chain amino acid metabolic process (GO:0009081)2.60930715
154positive regulation of prostaglandin secretion (GO:0032308)2.60813962
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59863677
156nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.57762556
157positive T cell selection (GO:0043368)2.57724293
158phosphatidylinositol acyl-chain remodeling (GO:0036149)2.56074409
159protein complex biogenesis (GO:0070271)2.55680822
160branched-chain amino acid catabolic process (GO:0009083)2.54783399
161RNA destabilization (GO:0050779)2.50614606
162regulation of histone phosphorylation (GO:0033127)2.49403725
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49164262
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.49164262
165NADH dehydrogenase complex assembly (GO:0010257)2.49164262
166cellular response to exogenous dsRNA (GO:0071360)2.47555290
167mucosal-associated lymphoid tissue development (GO:0048537)2.44774910
168Peyers patch development (GO:0048541)2.44774910
169negative regulation by host of viral transcription (GO:0043922)2.44755457
170positive regulation of icosanoid secretion (GO:0032305)2.43426186
171mitochondrial respiratory chain complex assembly (GO:0033108)2.43321535
172axoneme assembly (GO:0035082)2.42390502
173positive regulation of organelle assembly (GO:1902117)2.41456389
174detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41263841
175detection of light stimulus involved in visual perception (GO:0050908)2.41152575
176detection of light stimulus involved in sensory perception (GO:0050962)2.41152575
177negative regulation of mast cell activation (GO:0033004)2.40037911
178intra-S DNA damage checkpoint (GO:0031573)2.39491435
179regulation of memory T cell differentiation (GO:0043380)2.39386599
180positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.39086978
181nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39059802
182DNA catabolic process, exonucleolytic (GO:0000738)2.38509870
183negative regulation of viral genome replication (GO:0045071)2.37425006
184natural killer cell activation involved in immune response (GO:0002323)2.36371192
185exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36248817
186cytidine deamination (GO:0009972)2.36234763
187cytidine metabolic process (GO:0046087)2.36234763
188cytidine catabolic process (GO:0006216)2.36234763
189magnesium ion transport (GO:0015693)2.36049365
190tRNA modification (GO:0006400)2.34861818
191nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.33113666
192L-methionine biosynthetic process (GO:0071265)2.32000680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.77550994
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.05695429
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.45304701
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.19328961
5ZNF274_21170338_ChIP-Seq_K562_Hela3.87953931
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71188602
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.47438810
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.34145041
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.29516617
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.24476199
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23759058
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10265253
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94765160
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.88026956
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.85867051
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.74158441
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61985481
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51557632
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36860768
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.36227096
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.36227096
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.36227096
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35181729
24CIITA_25753668_ChIP-Seq_RAJI_Human2.31686064
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.30466905
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25364475
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24823928
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22686750
29EWS_26573619_Chip-Seq_HEK293_Human2.21584646
30VDR_24787735_ChIP-Seq_THP-1_Human2.14027780
31VDR_22108803_ChIP-Seq_LS180_Human2.12175896
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07748645
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00224969
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94254224
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.90519438
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90513375
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90029333
38RUNX_20019798_ChIP-Seq_JUKART_Human1.89822122
39IRF1_19129219_ChIP-ChIP_H3396_Human1.88585370
40VDR_23849224_ChIP-Seq_CD4+_Human1.87021401
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83205524
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.82189341
43ZNF263_19887448_ChIP-Seq_K562_Human1.81643254
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80675723
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79603380
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75153743
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74495479
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73515423
49* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73304811
50* MAF_26560356_Chip-Seq_TH1_Human1.72945354
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.71909225
52MYC_18940864_ChIP-ChIP_HL60_Human1.71787700
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70276347
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69153775
55FUS_26573619_Chip-Seq_HEK293_Human1.67900633
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66995188
57MYB_26560356_Chip-Seq_TH2_Human1.62984586
58ER_23166858_ChIP-Seq_MCF-7_Human1.60827039
59GBX2_23144817_ChIP-Seq_PC3_Human1.57138775
60* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55315380
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54623117
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54546021
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53535923
64SCL_19346495_ChIP-Seq_HPC-7_Human1.53060598
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.52362489
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.50038631
67TP53_22573176_ChIP-Seq_HFKS_Human1.47917652
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47543933
69GATA1_22025678_ChIP-Seq_K562_Human1.46668045
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45105323
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45105323
72E2F7_22180533_ChIP-Seq_HELA_Human1.44908960
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.43686530
74SPI1_23547873_ChIP-Seq_NB4_Human1.43369090
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40236477
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38668085
77* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38416380
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.38281184
79AR_20517297_ChIP-Seq_VCAP_Human1.37079821
80CBP_20019798_ChIP-Seq_JUKART_Human1.36969757
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36969757
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36004161
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32686001
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.32255928
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31745970
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31463659
87SOX2_19829295_ChIP-Seq_ESCs_Human1.30618844
88NANOG_19829295_ChIP-Seq_ESCs_Human1.30618844
89CLOCK_20551151_ChIP-Seq_293T_Human1.29520105
90ELK1_19687146_ChIP-ChIP_HELA_Human1.29426286
91TCF7_22412390_ChIP-Seq_EML_Mouse1.29214349
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28182553
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25225445
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.25225445
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23808812
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22595056
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21171965
98FOXP3_21729870_ChIP-Seq_TREG_Human1.20484017
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20421394
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20040036
101P300_19829295_ChIP-Seq_ESCs_Human1.19870439
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18946947
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18772010
104TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18690542
105GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.15914208
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15433805
107* PU_27001747_Chip-Seq_BMDM_Mouse1.13973293
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13849648
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12909015
110NCOR_22424771_ChIP-Seq_293T_Human1.12687347
111GATA3_27048872_Chip-Seq_THYMUS_Human1.12057153
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11707474
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11666779
114* MYB_26560356_Chip-Seq_TH1_Human1.11517775
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.11418376
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.10527552
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.09516104
118BRD4_25478319_ChIP-Seq_HGPS_Human1.07397293
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.06811083
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04942006
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04639777
122CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04475746
123TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03610200
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02407674
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01529808
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00472009
127ETS1_20019798_ChIP-Seq_JURKAT_Human0.99546603
128IGF1R_20145208_ChIP-Seq_DFB_Human0.99359183
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99289823
130* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99283549
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99269324
132* SOX2_20726797_ChIP-Seq_SW620_Human0.98902177
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98402272
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97613382
135PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97465666
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96804240
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95272349
138BCAT_22108803_ChIP-Seq_LS180_Human0.94400802
139* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93106360
140VDR_21846776_ChIP-Seq_THP-1_Human0.92443530
141* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92184495
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89587007
143* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89483325
144* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89037852
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88879822
146GATA3_26560356_Chip-Seq_TH1_Human0.88198184
147KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88194540
148CDX2_22108803_ChIP-Seq_LS180_Human0.88054655
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87595619
150TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87441861
151PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86676628
152GATA3_26560356_Chip-Seq_TH2_Human0.86341068
153CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85998069
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85504239
155ELK3_25401928_ChIP-Seq_HUVEC_Human0.85405103
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85342104
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85336521
158E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85309020
159FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84704348
160PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84679417
161* TCF4_23295773_ChIP-Seq_U87_Human0.84507145
162ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84340467
163* TAF2_19829295_ChIP-Seq_ESCs_Human0.83966532
164CDX2_20551321_ChIP-Seq_CACO-2_Human0.83691210
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83635361
166NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82980497
167VDR_24763502_ChIP-Seq_THP-1_Human0.82510468
168POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81994941
169CJUN_26792858_Chip-Seq_BT549_Human0.80509719
170* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80299795
171ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79579823
172VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79457809
173RUNX1_22412390_ChIP-Seq_EML_Mouse0.75614055
174* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75432121
175SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74879982
176SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74396186
177GATA2_21666600_ChIP-Seq_HMVEC_Human0.72405241
178NANOG_18692474_ChIP-Seq_MEFs_Mouse0.71939178
179STAT1_20625510_ChIP-Seq_HELA_Human0.71782516
180SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71581420
181GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70625811
182TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70498902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland4.38476232
2MP0003303_peritoneal_inflammation4.25811505
3MP0009379_abnormal_foot_pigmentation4.05491474
4MP0000685_abnormal_immune_system3.92027664
5* MP0002138_abnormal_hepatobiliary_system3.51446421
6MP0002148_abnormal_hypersensitivity_rea3.42895035
7MP0005646_abnormal_pituitary_gland3.37403571
8MP0002163_abnormal_gland_morphology3.31580087
9MP0001835_abnormal_antigen_presentation3.04126711
10MP0001968_abnormal_touch/_nociception2.97626397
11MP0005671_abnormal_response_to2.97254124
12MP0003300_gastrointestinal_ulcer2.88375851
13MP0005387_immune_system_phenotype2.60099337
14MP0001790_abnormal_immune_system2.60099337
15MP0002277_abnormal_respiratory_mucosa2.56774255
16MP0002254_reproductive_system_inflammat2.49554646
17MP0001346_abnormal_lacrimal_gland2.37574842
18MP0008057_abnormal_DNA_replication2.27715388
19MP0003828_pulmonary_edema2.25193594
20MP0003941_abnormal_skin_development2.21614424
21MP0002876_abnormal_thyroid_physiology2.21044107
22MP0006054_spinal_hemorrhage2.20957548
23MP0005075_abnormal_melanosome_morpholog2.19757160
24MP0009785_altered_susceptibility_to2.19375428
25MP0004510_myositis2.14559085
26MP0003436_decreased_susceptibility_to2.11143028
27MP0004147_increased_porphyrin_level2.06936107
28MP0006292_abnormal_olfactory_placode2.04400887
29MP0002452_abnormal_antigen_presenting1.95764052
30MP0008877_abnormal_DNA_methylation1.93461373
31MP0005076_abnormal_cell_differentiation1.85441243
32MP0006072_abnormal_retinal_apoptosis1.84168734
33MP0003283_abnormal_digestive_organ1.84157818
34MP0000490_abnormal_crypts_of1.80894764
35MP0002837_dystrophic_cardiac_calcinosis1.78387585
36MP0001853_heart_inflammation1.75166345
37MP0001819_abnormal_immune_cell1.75028446
38MP0001800_abnormal_humoral_immune1.74942905
39MP0004808_abnormal_hematopoietic_stem1.74862423
40MP0010368_abnormal_lymphatic_system1.72166653
41MP0008058_abnormal_DNA_repair1.70793817
42MP0002420_abnormal_adaptive_immunity1.69964580
43MP0002009_preneoplasia1.68262775
44MP0005025_abnormal_response_to1.67336880
45MP0003195_calcinosis1.67283126
46MP0000013_abnormal_adipose_tissue1.66278251
47MP0005310_abnormal_salivary_gland1.64916895
48MP0005645_abnormal_hypothalamus_physiol1.64737933
49MP0002723_abnormal_immune_serum1.63529076
50MP0008872_abnormal_physiological_respon1.61686273
51MP0005379_endocrine/exocrine_gland_phen1.61368386
52MP0001879_abnormal_lymphatic_vessel1.59630785
53MP0002166_altered_tumor_susceptibility1.59024980
54MP0004885_abnormal_endolymph1.58782795
55MP0005000_abnormal_immune_tolerance1.56846857
56MP0003724_increased_susceptibility_to1.56448188
57MP0008875_abnormal_xenobiotic_pharmacok1.55708454
58MP0002638_abnormal_pupillary_reflex1.55304380
59MP0010155_abnormal_intestine_physiology1.54400889
60MP0002419_abnormal_innate_immunity1.53661916
61MP0003806_abnormal_nucleotide_metabolis1.53628891
62MP0008775_abnormal_heart_ventricle1.51665300
63MP0001986_abnormal_taste_sensitivity1.47936275
64MP0003763_abnormal_thymus_physiology1.47880343
65MP0008995_early_reproductive_senescence1.44872046
66MP0005167_abnormal_blood-brain_barrier1.44766125
67MP0000230_abnormal_systemic_arterial1.41027858
68MP0010352_gastrointestinal_tract_polyps1.40543001
69MP0004043_abnormal_pH_regulation1.40445419
70MP0003866_abnormal_defecation1.39476631
71MP0002736_abnormal_nociception_after1.38369119
72MP0002102_abnormal_ear_morphology1.37119293
73MP0004782_abnormal_surfactant_physiolog1.33464364
74MP0009278_abnormal_bone_marrow1.32324420
75MP0000716_abnormal_immune_system1.31104107
76MP0002160_abnormal_reproductive_system1.29745311
77MP0002006_tumorigenesis1.29523293
78MP0009697_abnormal_copulation1.27427577
79MP0002405_respiratory_system_inflammati1.26996564
80MP0005389_reproductive_system_phenotype1.26431180
81MP0000372_irregular_coat_pigmentation1.26318210
82MP0005084_abnormal_gallbladder_morpholo1.26085842
83MP0002396_abnormal_hematopoietic_system1.20897609
84MP0000569_abnormal_digit_pigmentation1.19698890
85MP0004084_abnormal_cardiac_muscle1.19161928
86MP0003252_abnormal_bile_duct1.18901231
87MP0002398_abnormal_bone_marrow1.18467481
88MP0003448_altered_tumor_morphology1.17516980
89MP0002733_abnormal_thermal_nociception1.15815548
90MP0004145_abnormal_muscle_electrophysio1.14794108
91MP0009333_abnormal_splenocyte_physiolog1.14558707
92MP0003718_maternal_effect1.13957574
93MP0005551_abnormal_eye_electrophysiolog1.13475724
94MP0009764_decreased_sensitivity_to1.11860452
95MP0005360_urolithiasis1.10883332
96MP0008007_abnormal_cellular_replicative1.10120607
97MP0008789_abnormal_olfactory_epithelium1.09077994
98MP0003943_abnormal_hepatobiliary_system1.08655638
99MP0004185_abnormal_adipocyte_glucose1.07799847
100MP0005367_renal/urinary_system_phenotyp1.07614128
101MP0000516_abnormal_urinary_system1.07614128
102MP0005410_abnormal_fertilization1.06837048
103MP0002877_abnormal_melanocyte_morpholog1.06763329
104MP0006082_CNS_inflammation1.06349991
105MP0000627_abnormal_mammary_gland1.06259165
106MP0002735_abnormal_chemical_nociception1.02930512
107MP0003786_premature_aging1.02102666
108MP0003646_muscle_fatigue1.01381149
109MP0002429_abnormal_blood_cell0.98604695
110MP0003566_abnormal_cell_adhesion0.97021262
111MP0001764_abnormal_homeostasis0.94064954
112MP0003879_abnormal_hair_cell0.93769758
113MP0005397_hematopoietic_system_phenotyp0.92464801
114MP0001545_abnormal_hematopoietic_system0.92464801
115MP0001881_abnormal_mammary_gland0.91424152
116MP0002722_abnormal_immune_system0.91020916
117MP0006276_abnormal_autonomic_nervous0.90542109
118MP0001845_abnormal_inflammatory_respons0.89537429
119MP0005423_abnormal_somatic_nervous0.88718894
120MP0003091_abnormal_cell_migration0.88481482
121MP0009765_abnormal_xenobiotic_induced0.86517188
122MP0005464_abnormal_platelet_physiology0.84253167
123MP0005332_abnormal_amino_acid0.82155292
124MP0000689_abnormal_spleen_morphology0.81906723
125MP0005253_abnormal_eye_physiology0.80874636
126MP0008469_abnormal_protein_level0.79315015
127MP0003878_abnormal_ear_physiology0.79043125
128MP0005377_hearing/vestibular/ear_phenot0.79043125
129MP0005248_abnormal_Harderian_gland0.78099041
130MP0000470_abnormal_stomach_morphology0.77472560
131MP0003453_abnormal_keratinocyte_physiol0.77275386
132* MP0000613_abnormal_salivary_gland0.77015702
133MP0000467_abnormal_esophagus_morphology0.75121618
134MP0001919_abnormal_reproductive_system0.74426796
135MP0010386_abnormal_urinary_bladder0.73710188
136MP0001533_abnormal_skeleton_physiology0.72765148
137MP0002998_abnormal_bone_remodeling0.72661859
138MP0005174_abnormal_tail_pigmentation0.72376287
139MP0005595_abnormal_vascular_smooth0.72354156
140MP0002751_abnormal_autonomic_nervous0.72022708
141MP0000653_abnormal_sex_gland0.71643510
142MP0000703_abnormal_thymus_morphology0.71108308
143MP0004215_abnormal_myocardial_fiber0.70446063
144MP0001970_abnormal_pain_threshold0.69469200
145MP0005394_taste/olfaction_phenotype0.69332752
146MP0005499_abnormal_olfactory_system0.69332752
147MP0002019_abnormal_tumor_incidence0.69063582
148MP0005085_abnormal_gallbladder_physiolo0.68965144
149MP0001661_extended_life_span0.68700650
150MP0000858_altered_metastatic_potential0.67346073
151MP0003890_abnormal_embryonic-extraembry0.66624846
152MP0001663_abnormal_digestive_system0.65502332
153MP0003186_abnormal_redox_activity0.64307832
154MP0000767_abnormal_smooth_muscle0.63478821
155MP0001851_eye_inflammation0.63444263
156MP0002098_abnormal_vibrissa_morphology0.62708002
157MP0000678_abnormal_parathyroid_gland0.61506834
158MP0000249_abnormal_blood_vessel0.61492776
159MP0003936_abnormal_reproductive_system0.61382364
160MP0001873_stomach_inflammation0.61020688

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.89154603
2Stomatitis (HP:0010280)5.02305316
3Tetraparesis (HP:0002273)4.90968901
4Abnormality of macrophages (HP:0004311)4.51600477
5Panhypogammaglobulinemia (HP:0003139)4.49752773
6Abnormality of proline metabolism (HP:0010907)4.32315565
7Hydroxyprolinuria (HP:0003080)4.32315565
8Abnormality of B cell number (HP:0010975)4.08910507
9Abolished electroretinogram (ERG) (HP:0000550)4.02980054
10Recurrent bacterial skin infections (HP:0005406)3.99477185
11Fair hair (HP:0002286)3.98205534
12Recurrent gram-negative bacterial infections (HP:0005420)3.86400218
13Increased IgM level (HP:0003496)3.83267333
14Spontaneous hematomas (HP:0007420)3.80537741
15Recurrent fungal infections (HP:0002841)3.72197105
16Abnormality of the prostate (HP:0008775)3.71814672
17Autoimmune thrombocytopenia (HP:0001973)3.65006620
18Myocardial infarction (HP:0001658)3.62254598
19B lymphocytopenia (HP:0010976)3.60105133
20Mediastinal lymphadenopathy (HP:0100721)3.52780394
21Exertional dyspnea (HP:0002875)3.51748030
22Abnormal pupillary function (HP:0007686)3.50712554
23Congenital stationary night blindness (HP:0007642)3.48931976
24Recurrent abscess formation (HP:0002722)3.48549788
25Dry hair (HP:0011359)3.45158364
26Abnormality of secondary sexual hair (HP:0009888)3.38446869
27Abnormality of the axillary hair (HP:0100134)3.38446869
28Thrombocytosis (HP:0001894)3.31561308
29Pancreatic cysts (HP:0001737)3.29491497
30Hematochezia (HP:0002573)3.25169794
31Vertebral compression fractures (HP:0002953)3.23179533
32Hypoproteinemia (HP:0003075)3.16598684
33Esophageal varix (HP:0002040)3.11776265
34Ulnar claw (HP:0001178)3.10421459
35Stomach cancer (HP:0012126)3.09406971
36Abnormal hemoglobin (HP:0011902)3.07036266
37Fatigue (HP:0012378)3.06280107
38Cellulitis (HP:0100658)3.05990403
39Recurrent pneumonia (HP:0006532)3.01108899
40Abnormality of midbrain morphology (HP:0002418)2.99525584
41Molar tooth sign on MRI (HP:0002419)2.99525584
42Chronic obstructive pulmonary disease (HP:0006510)2.99485058
43Obstructive lung disease (HP:0006536)2.99485058
44Polycythemia (HP:0001901)2.94558955
45Generalized hypopigmentation of hair (HP:0011358)2.93835625
46Abnormality of T cell number (HP:0011839)2.93726490
47Pancreatic fibrosis (HP:0100732)2.84994997
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.84076517
49Prolonged neonatal jaundice (HP:0006579)2.82358534
50Amelogenesis imperfecta (HP:0000705)2.81674834
51Porencephaly (HP:0002132)2.76614270
52Anhidrosis (HP:0000970)2.75494725
53Attenuation of retinal blood vessels (HP:0007843)2.74629433
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.70814589
55Abnormal rod and cone electroretinograms (HP:0008323)2.70692604
56Agammaglobulinemia (HP:0004432)2.69359915
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69267050
58Gingival bleeding (HP:0000225)2.68963789
59Interstitial pulmonary disease (HP:0006530)2.66496391
60Hypothermia (HP:0002045)2.66100893
61Amaurosis fugax (HP:0100576)2.64645850
62Decreased circulating renin level (HP:0003351)2.64059798
63Arterial thrombosis (HP:0004420)2.62981407
64Nephronophthisis (HP:0000090)2.60356533
65Gastrointestinal infarctions (HP:0005244)2.57874270
66Vasculitis (HP:0002633)2.57362147
67Hypochromic anemia (HP:0001931)2.52891637
68Recurrent lower respiratory tract infections (HP:0002783)2.50563044
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50398182
70Retrobulbar optic neuritis (HP:0100654)2.49781502
71Optic neuritis (HP:0100653)2.49781502
72Meningitis (HP:0001287)2.46648521
73Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45326168
74Abnormality of the renal cortex (HP:0011035)2.43601506
75Abnormality of the phalanges of the 5th finger (HP:0004213)2.42065943
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.41201017
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41046946
78Abnormality of the renal medulla (HP:0100957)2.39555105
79Osteomyelitis (HP:0002754)2.38895409
80Abnormality of the intervertebral disk (HP:0005108)2.36438267
81Abnormality of eosinophils (HP:0001879)2.34157440
82Leukocytosis (HP:0001974)2.33508742
83Recurrent viral infections (HP:0004429)2.33245717
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.32800669
85Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.32139780
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29963568
87Decreased central vision (HP:0007663)2.29054139
88Abnormality of the proximal phalanges of the hand (HP:0009834)2.28938651
89Combined immunodeficiency (HP:0005387)2.28622114
90Ventricular tachycardia (HP:0004756)2.27585513
91Abnormal drinking behavior (HP:0030082)2.27116952
92Polydipsia (HP:0001959)2.27116952
93Basal ganglia calcification (HP:0002135)2.26381414
94True hermaphroditism (HP:0010459)2.26297628
95Urticaria (HP:0001025)2.25063139
96Thyroiditis (HP:0100646)2.24138096
97Gingivitis (HP:0000230)2.21395908
98Portal hypertension (HP:0001409)2.20335809
99Pustule (HP:0200039)2.19628832
100Eosinophilia (HP:0001880)2.19604076
101Constricted visual fields (HP:0001133)2.19544074
102Sepsis (HP:0100806)2.19046095
103Granulocytopenia (HP:0001913)2.18216259
104Abnormality of T cells (HP:0002843)2.15972234
105Neonatal hypoglycemia (HP:0001998)2.15829636
106T lymphocytopenia (HP:0005403)2.15232585
107Elevated erythrocyte sedimentation rate (HP:0003565)2.14830933
108Aplastic anemia (HP:0001915)2.14064325
109Orchitis (HP:0100796)2.13794548
110Abnormal biliary tract physiology (HP:0012439)2.11805625
111Bile duct proliferation (HP:0001408)2.11805625
112Aplasia/Hypoplasia involving the musculature (HP:0001460)2.11704268
113Clumsiness (HP:0002312)2.11070907
114Premature loss of primary teeth (HP:0006323)2.10552580
115Lower limb amyotrophy (HP:0007210)2.10433293
116Abnormality of the hepatic vasculature (HP:0006707)2.10327211
117Delayed CNS myelination (HP:0002188)2.09778952
118Episodic fever (HP:0001954)2.09479287
119Keratoconus (HP:0000563)2.08849536
120Increased corneal curvature (HP:0100692)2.08849536
121Abnormality of male internal genitalia (HP:0000022)2.08345366
122Chronic sinusitis (HP:0011109)2.07653044
123Recurrent skin infections (HP:0001581)2.07267797
124Progressive hearing impairment (HP:0001730)2.06323685
125Gaze-evoked nystagmus (HP:0000640)2.06134894
126Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05630585
1273-Methylglutaconic aciduria (HP:0003535)2.03083444
128Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.01182121
129Short 1st metacarpal (HP:0010034)2.01182121
130Cleft eyelid (HP:0000625)2.01158695
131Type I transferrin isoform profile (HP:0003642)2.00830507
132Chest pain (HP:0100749)1.97456539
133Severe combined immunodeficiency (HP:0004430)1.96703170
134Aplasia/Hypoplasia of the hallux (HP:0008362)1.96523973
135Myositis (HP:0100614)1.96495641
136Hyperphosphatemia (HP:0002905)1.95123862
137Short hallux (HP:0010109)1.94472820
138Methylmalonic acidemia (HP:0002912)1.93985869
139Microcytic anemia (HP:0001935)1.93327684
140Enlarged epiphyses (HP:0010580)1.92540027
141Vertebral arch anomaly (HP:0008438)1.92045983
142IgG deficiency (HP:0004315)1.91621262
143Prostate neoplasm (HP:0100787)1.90991843
144Pendular nystagmus (HP:0012043)1.89960025
145Abnormality of dental color (HP:0011073)1.89895859
146Ketosis (HP:0001946)1.89651331
147Tinnitus (HP:0000360)1.89415001
148Congenital, generalized hypertrichosis (HP:0004540)1.88727818
149Depressed nasal tip (HP:0000437)1.88568505
150Vacuolated lymphocytes (HP:0001922)1.86593940
151Impaired proprioception (HP:0010831)1.85489777
152Polyneuropathy (HP:0001271)1.83273728
153Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83077792
154Absent/shortened dynein arms (HP:0200106)1.82301572
155Dynein arm defect of respiratory motile cilia (HP:0012255)1.82301572
156Abnormality of T cell physiology (HP:0011840)1.81673332
157Ridged nail (HP:0001807)1.80864008
158Abnormality of alanine metabolism (HP:0010916)1.80469665
159Hyperalaninemia (HP:0003348)1.80469665
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80469665
161Peritonitis (HP:0002586)1.80209876
162Congenital sensorineural hearing impairment (HP:0008527)1.80063224
163Cystic liver disease (HP:0006706)1.80062243
164Acute lymphatic leukemia (HP:0006721)1.79575385
165Pulmonary fibrosis (HP:0002206)1.79344434
166Tubular atrophy (HP:0000092)1.79107458
167Progressive macrocephaly (HP:0004481)1.78696030
168Symphalangism affecting the phalanges of the hand (HP:0009773)1.78191534
169Abnormality of the middle phalanges of the toes (HP:0010183)1.78023699
170Polyuria (HP:0000103)1.77932670
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.77364480
172Azoospermia (HP:0000027)1.76918115
173Gastrointestinal inflammation (HP:0004386)1.76470541
174Lip pit (HP:0100267)1.76292892
175Abnormality of the 1st metacarpal (HP:0010009)1.75917452
176Aplasia/Hypoplasia of the tibia (HP:0005772)1.75870410
177Congenital hepatic fibrosis (HP:0002612)1.75671799
178Abnormal glycosylation (HP:0012345)1.75608525
179Prolonged bleeding time (HP:0003010)1.75501142
180Pulmonary artery stenosis (HP:0004415)1.75403037
181Cerebral hemorrhage (HP:0001342)1.73620595
182Hypergammaglobulinemia (HP:0010702)1.72837971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B6.55839660
2MAP3K144.14308548
3CDK83.91141252
4IRAK43.54608068
5KIT3.53455383
6IKBKB3.47951330
7NEK93.35823361
8CHUK3.09743172
9JAK32.97945321
10PIM22.85050060
11PKN22.74419742
12FLT32.67646198
13PINK12.57251924
14MAP4K22.54474706
15IRAK12.50962806
16TBK12.42533360
17TYK22.37611125
18GRK12.31711708
19BCKDK2.25575934
20MAPKAPK32.24369022
21IRAK22.22037276
22TRIB32.21770785
23MST41.91981989
24EPHA31.86762456
25PIM11.81396326
26IRAK31.78728973
27PLK21.77345831
28TAOK31.68240446
29NLK1.67600986
30JAK11.66797266
31BMX1.64688112
32IKBKE1.56173075
33ACVR1B1.45398171
34RIPK41.40253108
35TLK11.37410049
36FGFR31.34666020
37MAP3K131.33527799
38EIF2AK31.30439481
39DAPK21.28738788
40DDR21.26192993
41DYRK1B1.18695028
42CASK1.17639537
43STK41.17370378
44JAK21.15094798
45BCR1.09575999
46YES11.09551750
47FGFR41.08013790
48KDR1.07493047
49ABL21.07271608
50TRPM71.05527096
51INSRR1.04889160
52CDK61.00260813
53NUAK11.00188947
54FES0.99633777
55BLK0.98522406
56BMPR20.97096851
57ITK0.93788654
58NME20.92258040
59MKNK20.89717012
60CLK10.88829184
61ERBB30.87804768
62ZAK0.87135681
63PRKCE0.85204494
64CDK90.82764502
65PLK30.79050307
66LYN0.76700427
67DYRK20.76562231
68PIK3CA0.74054206
69MAPKAPK20.73914908
70DAPK30.73797679
71OXSR10.73787929
72RPS6KA50.72593279
73TESK10.71537258
74VRK20.70406749
75MAP4K10.70321724
76RET0.69784344
77DAPK10.69187828
78TIE10.66969860
79STK30.65926061
80VRK10.64408363
81CSNK1A1L0.64316468
82TGFBR10.64188420
83EPHA20.64107672
84EPHB10.63834942
85WNK40.63515921
86MAPK130.63023486
87CSK0.62730229
88MAPKAPK50.62646186
89RPS6KA40.58830340
90SCYL20.58694857
91MAP3K110.57605532
92ADRBK10.56543867
93STK240.55162758
94CDK30.54828036
95ATR0.54364353
96FRK0.53496554
97ABL10.53265121
98SYK0.51828697
99CDK70.51779280
100PKN10.50486508
101PHKG20.49608701
102PHKG10.49608701
103PRKCD0.49569751
104PTK60.47775324
105TEC0.45413887
106TXK0.45018704
107LCK0.44560639
108PRKCQ0.44253505
109CSF1R0.44007583
110GRK60.42542580
111RPS6KA10.42394425
112MAP2K20.42243101
113WNK30.41833290
114STK390.41176148
115PIK3CG0.40698090
116CSNK1A10.40506264
117MATK0.40416213
118EIF2AK20.40339924
119GRK70.39725242
120ZAP700.39090689
121MKNK10.39078974
122CSNK1G30.38794205
123HCK0.38746573
124HIPK20.38722135
125CDC70.38421850
126MET0.37955834
127IGF1R0.37861706
128AKT10.37548653
129PRKCI0.37528004
130FER0.37013746
131PTK2B0.34332371
132FGFR20.34282774
133GRK50.33488001
134MAP3K50.33174179
135PRKD20.32495799
136RPS6KB20.31890492
137PBK0.31453583
138AKT30.30542830
139BTK0.30125854
140MAP3K10.29886586
141ATM0.29813033
142CSNK1G10.29480706
143PRKCA0.28548754
144PASK0.27931921
145PAK30.27694650
146PLK40.27661971
147CHEK20.26889506
148CSNK1G20.26873755
149STK38L0.26846815
150BUB10.26610560
151ADRBK20.26551447

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.16655151
2Leishmaniasis_Homo sapiens_hsa051403.05503127
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.76576331
4Nitrogen metabolism_Homo sapiens_hsa009102.65429251
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.54610217
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.48605188
7Measles_Homo sapiens_hsa051622.42027171
8Autoimmune thyroid disease_Homo sapiens_hsa053202.39637243
9Toxoplasmosis_Homo sapiens_hsa051452.38283111
10Primary immunodeficiency_Homo sapiens_hsa053402.34856550
11Graft-versus-host disease_Homo sapiens_hsa053322.31768521
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23357513
13Systemic lupus erythematosus_Homo sapiens_hsa053222.21490352
14* Jak-STAT signaling pathway_Homo sapiens_hsa046302.18574038
15TNF signaling pathway_Homo sapiens_hsa046682.10825770
16Chemokine signaling pathway_Homo sapiens_hsa040622.00537125
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97383740
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.93172050
19Staphylococcus aureus infection_Homo sapiens_hsa051501.93157638
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82147666
21Osteoclast differentiation_Homo sapiens_hsa043801.80434006
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78644381
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76343933
24Shigellosis_Homo sapiens_hsa051311.75847961
25Herpes simplex infection_Homo sapiens_hsa051681.73619653
26Viral myocarditis_Homo sapiens_hsa054161.70064035
27Acute myeloid leukemia_Homo sapiens_hsa052211.69828805
28Linoleic acid metabolism_Homo sapiens_hsa005911.63742270
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62497481
30Caffeine metabolism_Homo sapiens_hsa002321.61272921
31Apoptosis_Homo sapiens_hsa042101.58898443
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.56292602
33Influenza A_Homo sapiens_hsa051641.55582941
34Selenocompound metabolism_Homo sapiens_hsa004501.48422861
35RNA degradation_Homo sapiens_hsa030181.47990387
36* Prolactin signaling pathway_Homo sapiens_hsa049171.47160520
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45038653
38Ribosome_Homo sapiens_hsa030101.43688527
39Epstein-Barr virus infection_Homo sapiens_hsa051691.37766931
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36068230
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35233831
42Pertussis_Homo sapiens_hsa051331.34966370
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32931596
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31970486
45Type I diabetes mellitus_Homo sapiens_hsa049401.29635920
46Phototransduction_Homo sapiens_hsa047441.24043961
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23153936
48Ether lipid metabolism_Homo sapiens_hsa005651.21441622
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19378033
50Non-homologous end-joining_Homo sapiens_hsa034501.19175947
51Peroxisome_Homo sapiens_hsa041461.18064142
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17094438
53B cell receptor signaling pathway_Homo sapiens_hsa046621.16197504
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15027607
55Rheumatoid arthritis_Homo sapiens_hsa053231.11960069
56Tuberculosis_Homo sapiens_hsa051521.10288233
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.09466806
58Hepatitis B_Homo sapiens_hsa051611.08896228
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07098354
60Dorso-ventral axis formation_Homo sapiens_hsa043201.06387661
61Chronic myeloid leukemia_Homo sapiens_hsa052201.04860623
62Legionellosis_Homo sapiens_hsa051341.03687142
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03166006
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.00862128
65Salmonella infection_Homo sapiens_hsa051320.96329562
66Hepatitis C_Homo sapiens_hsa051600.96224517
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95810984
68Platelet activation_Homo sapiens_hsa046110.95053997
69Small cell lung cancer_Homo sapiens_hsa052220.92435298
70Tryptophan metabolism_Homo sapiens_hsa003800.90979363
71Sulfur metabolism_Homo sapiens_hsa009200.90490942
72Butanoate metabolism_Homo sapiens_hsa006500.88605006
73Olfactory transduction_Homo sapiens_hsa047400.87700526
74HIF-1 signaling pathway_Homo sapiens_hsa040660.84833460
75Hematopoietic cell lineage_Homo sapiens_hsa046400.84532545
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.83570162
77Malaria_Homo sapiens_hsa051440.82840678
78Purine metabolism_Homo sapiens_hsa002300.81119144
79One carbon pool by folate_Homo sapiens_hsa006700.80633525
80T cell receptor signaling pathway_Homo sapiens_hsa046600.79610420
81Adherens junction_Homo sapiens_hsa045200.78774959
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76840802
83Fanconi anemia pathway_Homo sapiens_hsa034600.76282076
84Asthma_Homo sapiens_hsa053100.75905674
85Viral carcinogenesis_Homo sapiens_hsa052030.75704553
86HTLV-I infection_Homo sapiens_hsa051660.68586495
87Oxidative phosphorylation_Homo sapiens_hsa001900.68097622
88MicroRNAs in cancer_Homo sapiens_hsa052060.67744524
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66930100
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.66875794
91p53 signaling pathway_Homo sapiens_hsa041150.66403108
92Chemical carcinogenesis_Homo sapiens_hsa052040.66142812
93Homologous recombination_Homo sapiens_hsa034400.64279018
94Pathways in cancer_Homo sapiens_hsa052000.64025441
95Basal transcription factors_Homo sapiens_hsa030220.63254736
96Pyrimidine metabolism_Homo sapiens_hsa002400.62623096
97Antigen processing and presentation_Homo sapiens_hsa046120.62164713
98Endometrial cancer_Homo sapiens_hsa052130.60558298
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59900169
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59862909
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59005162
102Regulation of autophagy_Homo sapiens_hsa041400.58623045
103Proteasome_Homo sapiens_hsa030500.58103386
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58081200
105Propanoate metabolism_Homo sapiens_hsa006400.56442709
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55584147
107Prostate cancer_Homo sapiens_hsa052150.54758285
108FoxO signaling pathway_Homo sapiens_hsa040680.54517717
109Taste transduction_Homo sapiens_hsa047420.54263179
110Salivary secretion_Homo sapiens_hsa049700.53955805
111Parkinsons disease_Homo sapiens_hsa050120.53705625
112Ovarian steroidogenesis_Homo sapiens_hsa049130.53475034
113TGF-beta signaling pathway_Homo sapiens_hsa043500.52637056
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52577478
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51938401
116Notch signaling pathway_Homo sapiens_hsa043300.51687945
117ErbB signaling pathway_Homo sapiens_hsa040120.50926339
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50006090
119Retinol metabolism_Homo sapiens_hsa008300.49595459
120Base excision repair_Homo sapiens_hsa034100.47526394
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45023678
122Alcoholism_Homo sapiens_hsa050340.44489939
123Renin secretion_Homo sapiens_hsa049240.43799105
124African trypanosomiasis_Homo sapiens_hsa051430.43043336
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41894177
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41783629
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41561303
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.40734389
129Phagosome_Homo sapiens_hsa041450.40137125
130Thyroid cancer_Homo sapiens_hsa052160.39577997
131VEGF signaling pathway_Homo sapiens_hsa043700.38669084
132RNA transport_Homo sapiens_hsa030130.35963548
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35944453
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.35420202
135Colorectal cancer_Homo sapiens_hsa052100.35073773
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34782865
137Melanoma_Homo sapiens_hsa052180.34479600
138Nucleotide excision repair_Homo sapiens_hsa034200.33313740
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32773974
140Proteoglycans in cancer_Homo sapiens_hsa052050.31871631
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31491008
142Pancreatic cancer_Homo sapiens_hsa052120.31424126
143Protein export_Homo sapiens_hsa030600.31365965
144Non-small cell lung cancer_Homo sapiens_hsa052230.30956636
145RNA polymerase_Homo sapiens_hsa030200.30645825
146Fatty acid degradation_Homo sapiens_hsa000710.30179577
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30002692
148Arachidonic acid metabolism_Homo sapiens_hsa005900.30000231
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.29985511
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.29029065
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.28771455
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28723363
153beta-Alanine metabolism_Homo sapiens_hsa004100.28468572
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28121053
155Circadian entrainment_Homo sapiens_hsa047130.28054388
156Fat digestion and absorption_Homo sapiens_hsa049750.25489497
157Vitamin digestion and absorption_Homo sapiens_hsa049770.25313143
158Serotonergic synapse_Homo sapiens_hsa047260.23437179
159ABC transporters_Homo sapiens_hsa020100.23211007
160Calcium signaling pathway_Homo sapiens_hsa040200.22911344

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