SNX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.53384473
2positive regulation of mitochondrial fission (GO:0090141)5.45340154
3nucleobase catabolic process (GO:0046113)5.43426117
4response to pheromone (GO:0019236)4.72553380
5COPI coating of Golgi vesicle (GO:0048205)4.43582692
6Golgi transport vesicle coating (GO:0048200)4.43582692
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.00212328
8neural tube formation (GO:0001841)3.84294140
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62015048
10establishment of mitochondrion localization (GO:0051654)3.59356632
11ribonucleoprotein complex disassembly (GO:0032988)3.58107871
12DNA double-strand break processing (GO:0000729)3.56738346
13organelle disassembly (GO:1903008)3.51802872
14cullin deneddylation (GO:0010388)3.50341132
15intraciliary transport (GO:0042073)3.49869061
16positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.49255363
17mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.49255363
18histone H2A acetylation (GO:0043968)3.39692584
19protein deneddylation (GO:0000338)3.37219065
20ubiquinone metabolic process (GO:0006743)3.34833152
21formation of translation preinitiation complex (GO:0001731)3.28386257
22regulation of mitochondrial fission (GO:0090140)3.27323782
23proteasome assembly (GO:0043248)3.19913750
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19832631
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19832631
26nuclear pore complex assembly (GO:0051292)3.09103686
27ubiquinone biosynthetic process (GO:0006744)3.08899865
28nuclear pore organization (GO:0006999)3.05344224
29mitotic nuclear envelope disassembly (GO:0007077)3.02569847
30iron-sulfur cluster assembly (GO:0016226)3.02400217
31metallo-sulfur cluster assembly (GO:0031163)3.02400217
32regulation of sarcomere organization (GO:0060297)3.00893671
33DNA damage response, detection of DNA damage (GO:0042769)2.96020825
34DNA integration (GO:0015074)2.95919641
35cholesterol biosynthetic process (GO:0006695)2.93744132
36amino acid salvage (GO:0043102)2.93313737
37L-methionine salvage (GO:0071267)2.93313737
38L-methionine biosynthetic process (GO:0071265)2.93313737
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92967574
40actin nucleation (GO:0045010)2.92508162
41quinone biosynthetic process (GO:1901663)2.92133431
42folic acid-containing compound biosynthetic process (GO:0009396)2.91976083
43membrane disassembly (GO:0030397)2.87046610
44nuclear envelope disassembly (GO:0051081)2.87046610
45quinone metabolic process (GO:1901661)2.85893101
46protein localization to cilium (GO:0061512)2.84490121
47glycosphingolipid biosynthetic process (GO:0006688)2.84081144
48positive regulation of gamma-delta T cell activation (GO:0046645)2.83367969
49anterograde synaptic vesicle transport (GO:0048490)2.82051478
50de novo protein folding (GO:0006458)2.80699176
51de novo posttranslational protein folding (GO:0051084)2.77745868
52isoprenoid biosynthetic process (GO:0008299)2.77079194
53regulation of spindle organization (GO:0090224)2.76973124
54centriole replication (GO:0007099)2.76286613
55antigen processing and presentation of endogenous antigen (GO:0019883)2.74689838
56B cell mediated immunity (GO:0019724)2.73525631
57purine nucleobase biosynthetic process (GO:0009113)2.72793721
58seminiferous tubule development (GO:0072520)2.71564646
59replication fork processing (GO:0031297)2.70808257
60DNA unwinding involved in DNA replication (GO:0006268)2.69893319
61piRNA metabolic process (GO:0034587)2.68006080
62IMP metabolic process (GO:0046040)2.67384789
63ribosome assembly (GO:0042255)2.67074341
64immunoglobulin mediated immune response (GO:0016064)2.66962746
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66667550
66regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.63177975
67regulation of development, heterochronic (GO:0040034)2.61012079
68mitochondrial fission (GO:0000266)2.59961814
69membrane budding (GO:0006900)2.59656467
70regulation of response to interferon-gamma (GO:0060330)2.59269008
71pyrimidine dimer repair (GO:0006290)2.58877978
72regulation of Golgi to plasma membrane protein transport (GO:0042996)2.58758353
73nucleobase biosynthetic process (GO:0046112)2.58708039
74mitochondrion transport along microtubule (GO:0047497)2.58404092
75establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.58404092
76protein polyglutamylation (GO:0018095)2.58317690
77morphogenesis of an endothelium (GO:0003159)2.56598510
78endothelial tube morphogenesis (GO:0061154)2.56598510
79sterol biosynthetic process (GO:0016126)2.54968704
80regulation of mitotic spindle organization (GO:0060236)2.54616598
81DNA ligation (GO:0006266)2.54362816
82regulation of cofactor metabolic process (GO:0051193)2.53019956
83regulation of coenzyme metabolic process (GO:0051196)2.53019956
84IMP biosynthetic process (GO:0006188)2.52866930
85oxidative demethylation (GO:0070989)2.52858951
86negative regulation of DNA recombination (GO:0045910)2.52177015
87positive regulation of protein import into nucleus, translocation (GO:0033160)2.51122124
88regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.50288794
89mitotic chromosome condensation (GO:0007076)2.50255574
90neutrophil activation involved in immune response (GO:0002283)2.49451150
91S-adenosylmethionine metabolic process (GO:0046500)2.49204588
92protein neddylation (GO:0045116)2.48561184
93protein K11-linked ubiquitination (GO:0070979)2.47879189
94regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47858553
95negative regulation of fibroblast apoptotic process (GO:2000270)2.46266126
96antigen processing and presentation via MHC class Ib (GO:0002475)2.44532654
97protein K48-linked ubiquitination (GO:0070936)2.44483357
98sequestering of actin monomers (GO:0042989)2.44464612
99resolution of meiotic recombination intermediates (GO:0000712)2.43674752
100microtubule-based transport (GO:0010970)2.42692975
101establishment of melanosome localization (GO:0032401)2.42462061
102keratinocyte development (GO:0003334)2.41795379
103regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.41296923
104regulation of protein heterodimerization activity (GO:0043497)2.41032616
105histone mRNA metabolic process (GO:0008334)2.40952300
106pore complex assembly (GO:0046931)2.40880107
107CENP-A containing nucleosome assembly (GO:0034080)2.40725867
108peroxisome fission (GO:0016559)2.40472315
109endosome to melanosome transport (GO:0035646)2.39559188
110endosome to pigment granule transport (GO:0043485)2.39559188
111prenylation (GO:0097354)2.39517573
112protein prenylation (GO:0018342)2.39517573
113establishment of pigment granule localization (GO:0051905)2.38993920
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.38979974
115monoubiquitinated protein deubiquitination (GO:0035520)2.38776902
116neuronal action potential propagation (GO:0019227)2.38255997
117organelle transport along microtubule (GO:0072384)2.38247041
118regulation of helicase activity (GO:0051095)2.37915416
119sialylation (GO:0097503)2.37725292
120cornea development in camera-type eye (GO:0061303)2.37605817
121cytoskeleton-dependent intracellular transport (GO:0030705)2.37313479
122succinate metabolic process (GO:0006105)2.37042956
123protein retention in ER lumen (GO:0006621)2.36956727
124calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.36378953
125regulation of SMAD protein import into nucleus (GO:0060390)2.35967791
126regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.35881278
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.35221857
128maturation of SSU-rRNA (GO:0030490)2.35027368
129melanosome transport (GO:0032402)2.33813462
130protein localization to kinetochore (GO:0034501)2.33597082
131regulation of acyl-CoA biosynthetic process (GO:0050812)2.32280337
132positive regulation of lamellipodium assembly (GO:0010592)2.32168401
133glial cell proliferation (GO:0014009)2.31950576
134nuclear envelope organization (GO:0006998)2.31897257
135COPII vesicle coating (GO:0048208)2.31773795
136barbed-end actin filament capping (GO:0051016)2.31646114
137chromatin remodeling at centromere (GO:0031055)2.31318143
138pigment granule transport (GO:0051904)2.30580796
139methionine metabolic process (GO:0006555)2.28687028
140microtubule anchoring (GO:0034453)2.28350510
141mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.28343532
142T cell apoptotic process (GO:0070231)2.28191300
143DNA strand elongation involved in DNA replication (GO:0006271)2.27086627
144retinal cone cell development (GO:0046549)2.25860718
145negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.25606888
146hepatocyte apoptotic process (GO:0097284)2.24765311
147positive regulation of SMAD protein import into nucleus (GO:0060391)2.23818992
148dosage compensation (GO:0007549)2.23652446
149branched-chain amino acid catabolic process (GO:0009083)2.23004434
150sympathetic nervous system development (GO:0048485)2.22366572
151C-terminal protein amino acid modification (GO:0018410)2.21627598
152cilium morphogenesis (GO:0060271)2.20491601
153histone-serine phosphorylation (GO:0035404)2.20223578
154antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.20125325
155glyoxylate metabolic process (GO:0046487)2.20119976
156protein K6-linked ubiquitination (GO:0085020)2.20066629
157positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.19816756
158pinocytosis (GO:0006907)2.19319559
159positive regulation of lamellipodium organization (GO:1902745)2.18879215
160pentose-phosphate shunt (GO:0006098)2.18448020
161negative regulation of phagocytosis (GO:0050765)2.16346200
162DNA replication initiation (GO:0006270)2.16300837
163regulation of fibroblast apoptotic process (GO:2000269)2.14486582
164DNA strand elongation (GO:0022616)2.14005824
165mitotic sister chromatid cohesion (GO:0007064)2.13914170
166establishment of chromosome localization (GO:0051303)2.12949630
167regulation of translation in response to stress (GO:0043555)2.12927239
168cellular response to interferon-alpha (GO:0035457)2.12852217
169positive regulation of epithelial to mesenchymal transition (GO:0010718)2.11376229
170DNA replication-dependent nucleosome assembly (GO:0006335)2.10942960
171DNA replication-dependent nucleosome organization (GO:0034723)2.10942960
172NADPH regeneration (GO:0006740)2.10284096
173regulation of type I interferon-mediated signaling pathway (GO:0060338)2.10255905
174mitotic metaphase plate congression (GO:0007080)2.10068549
175postreplication repair (GO:0006301)2.09771455
176retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.07192197
177positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.05774416
178regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.05284464
179positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.05268278
180negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.04448276
1813-UTR-mediated mRNA stabilization (GO:0070935)2.04106875
182regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.03020006
183regulation of translational termination (GO:0006449)2.02849584
184ribosomal small subunit assembly (GO:0000028)2.02425709
185regulation of RIG-I signaling pathway (GO:0039535)2.02196019
186anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.01975915
187necroptotic process (GO:0070266)2.01475238
188regulation of interleukin-12 biosynthetic process (GO:0045075)2.00811611
189DNA geometric change (GO:0032392)2.00751941
190positive regulation of immune response to tumor cell (GO:0002839)2.00669886
191regulation of immune response to tumor cell (GO:0002837)2.00669886
192regulation of response to tumor cell (GO:0002834)2.00669886
193positive regulation of response to tumor cell (GO:0002836)2.00669886
194regulation of gamma-delta T cell differentiation (GO:0045586)2.00101696
195DNA duplex unwinding (GO:0032508)1.99803134
196positive regulation of interferon-alpha production (GO:0032727)1.99147875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.08575732
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.76424283
3IGF1R_20145208_ChIP-Seq_DFB_Human3.26297133
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16882426
5POU3F2_20337985_ChIP-ChIP_501MEL_Human3.00820173
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.82710397
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.65759891
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56508558
9ZNF274_21170338_ChIP-Seq_K562_Hela2.55513999
10GBX2_23144817_ChIP-Seq_PC3_Human2.48480255
11FUS_26573619_Chip-Seq_HEK293_Human2.45068086
12EWS_26573619_Chip-Seq_HEK293_Human2.42490120
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.39262703
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37318038
15TAF15_26573619_Chip-Seq_HEK293_Human2.36939334
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32908000
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.32484516
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30096398
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19873161
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.18901556
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11024565
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07918173
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07752764
24VDR_22108803_ChIP-Seq_LS180_Human2.03536877
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02279170
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02274795
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00134878
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98758489
29IRF1_19129219_ChIP-ChIP_H3396_Human1.98419996
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96027573
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95818159
32MYC_22102868_ChIP-Seq_BL_Human1.95015509
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94603735
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.91467671
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90530764
36AR_21909140_ChIP-Seq_LNCAP_Human1.89740193
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89617804
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86999078
39P300_19829295_ChIP-Seq_ESCs_Human1.84399678
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84114649
41VDR_23849224_ChIP-Seq_CD4+_Human1.83583746
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82305717
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.81134406
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81004314
45ELK1_19687146_ChIP-ChIP_HELA_Human1.80381962
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78356434
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76387021
48* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73930718
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72105796
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70515908
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69577234
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67416805
53SPI1_23547873_ChIP-Seq_NB4_Human1.66300670
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66121639
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.66106495
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66022412
57XRN2_22483619_ChIP-Seq_HELA_Human1.57623857
58ER_23166858_ChIP-Seq_MCF-7_Human1.57384099
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57231700
60TFEB_21752829_ChIP-Seq_HELA_Human1.56949895
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56335942
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56106766
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56085732
64DCP1A_22483619_ChIP-Seq_HELA_Human1.55975726
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55133073
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53032887
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50055447
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49968174
69* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49602222
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.49035729
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48937543
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48852652
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47797979
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47291570
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47139977
76MYB_26560356_Chip-Seq_TH2_Human1.46628541
77FOXP3_21729870_ChIP-Seq_TREG_Human1.45843863
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45670458
79CBP_20019798_ChIP-Seq_JUKART_Human1.45670458
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44261960
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43901385
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43597234
83* CLOCK_20551151_ChIP-Seq_293T_Human1.43177040
84* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41864339
85GABP_19822575_ChIP-Seq_HepG2_Human1.41611513
86HTT_18923047_ChIP-ChIP_STHdh_Human1.40409430
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39825682
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37484049
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36171010
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34477990
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33703942
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.33337601
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32674715
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31677444
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31573818
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31075731
97VDR_21846776_ChIP-Seq_THP-1_Human1.27546984
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26605221
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.23786291
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23502777
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23142496
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22801013
103SMAD4_21799915_ChIP-Seq_A2780_Human1.22166872
104MAF_26560356_Chip-Seq_TH1_Human1.22152675
105STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21849220
106* TAL1_26923725_Chip-Seq_HPCs_Mouse1.21502410
107CIITA_25753668_ChIP-Seq_RAJI_Human1.21029413
108TP53_22573176_ChIP-Seq_HFKS_Human1.20749421
109MYB_26560356_Chip-Seq_TH1_Human1.20741462
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20132204
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19065453
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19045950
113MYC_18940864_ChIP-ChIP_HL60_Human1.18416811
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18353942
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18210889
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16417601
117UTX_26944678_Chip-Seq_JUKART_Human1.15985545
118RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15859431
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15250690
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15094548
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13552136
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.13039743
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12730390
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12536706
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12234856
126NANOG_19829295_ChIP-Seq_ESCs_Human1.11350490
127SOX2_19829295_ChIP-Seq_ESCs_Human1.11350490
128AR_25329375_ChIP-Seq_VCAP_Human1.11254719
129P53_22387025_ChIP-Seq_ESCs_Mouse1.10881063
130RNF2_27304074_Chip-Seq_NSC_Mouse1.10825798
131IRF8_27001747_Chip-Seq_BMDM_Mouse1.10613090
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.10422335
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10083410
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09817903
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09777288
136SALL1_21062744_ChIP-ChIP_HESCs_Human1.08810292
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.08599903
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08515921
139RUNX1_22412390_ChIP-Seq_EML_Mouse1.08115752
140RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07812149
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07517180
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07170884
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05811639
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05599717
145STAT3_23295773_ChIP-Seq_U87_Human1.05480825
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05339293
147NOTCH1_21737748_ChIP-Seq_TLL_Human1.05144155
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04552064
149TTF2_22483619_ChIP-Seq_HELA_Human1.04404007
150SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03459566
151THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03243736
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03012922
153PIAS1_25552417_ChIP-Seq_VCAP_Human1.02776645
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02737333
155KDM5A_27292631_Chip-Seq_BREAST_Human1.02557539
156CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02297400
157REST_19997604_ChIP-ChIP_NEURONS_Mouse1.02294360
158GATA1_22025678_ChIP-Seq_K562_Human1.02112390
159NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01923250
160E2F1_18555785_Chip-Seq_ESCs_Mouse1.01291299
161P300_18555785_Chip-Seq_ESCs_Mouse1.01090485
162EZH2_22144423_ChIP-Seq_EOC_Human1.00623310
163FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99866594
164FLI1_21867929_ChIP-Seq_TH2_Mouse0.99865304
165HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99757551
166PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99638342
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99044386
168ELK1_22589737_ChIP-Seq_MCF10A_Human0.98329806
169* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96604447
170SRF_21415370_ChIP-Seq_HL-1_Mouse0.95120844
171ELK3_25401928_ChIP-Seq_HUVEC_Human0.94031455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.82430871
2MP0002102_abnormal_ear_morphology3.62184243
3MP0008438_abnormal_cutaneous_collagen3.56081606
4MP0001529_abnormal_vocalization3.30351795
5MP0008877_abnormal_DNA_methylation3.16642725
6MP0003121_genomic_imprinting2.94356823
7MP0010352_gastrointestinal_tract_polyps2.80296075
8MP0006054_spinal_hemorrhage2.77732989
9MP0003122_maternal_imprinting2.69690118
10MP0005645_abnormal_hypothalamus_physiol2.57978050
11MP0003693_abnormal_embryo_hatching2.52659089
12MP0001984_abnormal_olfaction2.47371614
13MP0005499_abnormal_olfactory_system2.39822471
14MP0005394_taste/olfaction_phenotype2.39822471
15MP0003705_abnormal_hypodermis_morpholog2.36687022
16MP0003880_abnormal_central_pattern2.33570452
17MP0008789_abnormal_olfactory_epithelium2.28922387
18MP0002396_abnormal_hematopoietic_system2.25712763
19MP0002139_abnormal_hepatobiliary_system2.18172143
20MP0004957_abnormal_blastocyst_morpholog2.17759272
21MP0002822_catalepsy2.17703969
22MP0009697_abnormal_copulation2.06912761
23MP0003436_decreased_susceptibility_to1.99709758
24MP0001835_abnormal_antigen_presentation1.96094059
25MP0003077_abnormal_cell_cycle1.90954538
26MP0000372_irregular_coat_pigmentation1.88101751
27MP0003195_calcinosis1.86505095
28MP0006276_abnormal_autonomic_nervous1.82885591
29MP0006035_abnormal_mitochondrial_morpho1.81660498
30MP0005275_abnormal_skin_tensile1.81564253
31MP0003566_abnormal_cell_adhesion1.74253806
32MP0005253_abnormal_eye_physiology1.74101991
33MP0004808_abnormal_hematopoietic_stem1.70973629
34MP0004147_increased_porphyrin_level1.70819190
35MP0005423_abnormal_somatic_nervous1.70166618
36MP0001958_emphysema1.68496822
37MP0009333_abnormal_splenocyte_physiolog1.68095967
38MP0009785_altered_susceptibility_to1.67109931
39MP0005503_abnormal_tendon_morphology1.64920814
40MP0010094_abnormal_chromosome_stability1.63291499
41MP0003279_aneurysm1.62536162
42MP0000685_abnormal_immune_system1.62125422
43MP0004270_analgesia1.62033250
44MP0005085_abnormal_gallbladder_physiolo1.60331239
45MP0003763_abnormal_thymus_physiology1.57919555
46MP0000569_abnormal_digit_pigmentation1.57882230
47MP0010307_abnormal_tumor_latency1.57392114
48MP0005023_abnormal_wound_healing1.55962554
49MP0003718_maternal_effect1.54060774
50MP0003123_paternal_imprinting1.53862793
51MP0009046_muscle_twitch1.52471453
52MP0005671_abnormal_response_to1.51629066
53MP0000778_abnormal_nervous_system1.51593707
54MP0008007_abnormal_cellular_replicative1.50815684
55MP0003890_abnormal_embryonic-extraembry1.49771055
56MP0008995_early_reproductive_senescence1.49593787
57MP0000858_altered_metastatic_potential1.49009515
58MP0001764_abnormal_homeostasis1.43873604
59MP0000490_abnormal_crypts_of1.43008437
60MP0005058_abnormal_lysosome_morphology1.40852457
61MP0003111_abnormal_nucleus_morphology1.40813384
62MP0005397_hematopoietic_system_phenotyp1.40156817
63MP0001545_abnormal_hematopoietic_system1.40156817
64MP0002909_abnormal_adrenal_gland1.37471088
65MP0003806_abnormal_nucleotide_metabolis1.36548897
66MP0002452_abnormal_antigen_presenting1.35385809
67MP0005084_abnormal_gallbladder_morpholo1.34786674
68MP0005386_behavior/neurological_phenoty1.34275782
69MP0004924_abnormal_behavior1.34275782
70MP0002398_abnormal_bone_marrow1.33376248
71MP0002419_abnormal_innate_immunity1.32453028
72MP0002405_respiratory_system_inflammati1.31254626
73MP0005000_abnormal_immune_tolerance1.30338824
74MP0003300_gastrointestinal_ulcer1.29882766
75MP0001533_abnormal_skeleton_physiology1.29446570
76MP0001730_embryonic_growth_arrest1.28811043
77MP0002638_abnormal_pupillary_reflex1.28601658
78MP0003252_abnormal_bile_duct1.27800273
79MP0002837_dystrophic_cardiac_calcinosis1.27732349
80MP0005551_abnormal_eye_electrophysiolog1.26996711
81MP0002420_abnormal_adaptive_immunity1.26956458
82MP0006036_abnormal_mitochondrial_physio1.26854576
83MP0001819_abnormal_immune_cell1.26799980
84MP0006072_abnormal_retinal_apoptosis1.26264805
85MP0002166_altered_tumor_susceptibility1.25944226
86MP0005025_abnormal_response_to1.24967728
87MP0005464_abnormal_platelet_physiology1.24663136
88MP0002877_abnormal_melanocyte_morpholog1.24430401
89MP0005076_abnormal_cell_differentiation1.23116680
90MP0002751_abnormal_autonomic_nervous1.22967959
91MP0004272_abnormal_basement_membrane1.21457307
92MP0000350_abnormal_cell_proliferation1.21441693
93MP0003448_altered_tumor_morphology1.20812699
94MP0002090_abnormal_vision1.18604754
95MP0001915_intracranial_hemorrhage1.18371173
96MP0002723_abnormal_immune_serum1.16965762
97MP0002722_abnormal_immune_system1.16667469
98MP0003724_increased_susceptibility_to1.16564076
99MP0001800_abnormal_humoral_immune1.16284115
100MP0002148_abnormal_hypersensitivity_rea1.16011267
101MP0010368_abnormal_lymphatic_system1.14124089
102MP0000689_abnormal_spleen_morphology1.13507629
103MP0000716_abnormal_immune_system1.13416514
104MP0010155_abnormal_intestine_physiology1.13065344
105MP0002933_joint_inflammation1.12753961
106MP0002019_abnormal_tumor_incidence1.11786966
107MP0003091_abnormal_cell_migration1.10952972
108MP0003786_premature_aging1.10250119
109MP0000343_altered_response_to1.09974945
110MP0004811_abnormal_neuron_physiology1.09684989
111MP0002006_tumorigenesis1.09338041
112MP0002429_abnormal_blood_cell1.08200560
113MP0001188_hyperpigmentation1.06378858
114MP0002160_abnormal_reproductive_system1.04217746
115MP0003186_abnormal_redox_activity1.03528247
116MP0002086_abnormal_extraembryonic_tissu1.01779234
117MP0001845_abnormal_inflammatory_respons1.01513521
118MP0003303_peritoneal_inflammation1.01431672
119MP0004782_abnormal_surfactant_physiolog1.00842576
120MP0002272_abnormal_nervous_system0.99827949
121MP0008932_abnormal_embryonic_tissue0.99703958
122MP0008875_abnormal_xenobiotic_pharmacok0.99165249
123MP0000703_abnormal_thymus_morphology0.98635858
124MP0006082_CNS_inflammation0.98341771
125MP0004145_abnormal_muscle_electrophysio0.98267435
126MP0002557_abnormal_social/conspecific_i0.98143103
127MP0000647_abnormal_sebaceous_gland0.97873632
128MP0000465_gastrointestinal_hemorrhage0.97798435
129MP0004215_abnormal_myocardial_fiber0.97581514
130MP0001697_abnormal_embryo_size0.96605353
131MP0003221_abnormal_cardiomyocyte_apopto0.96448966
132MP0001790_abnormal_immune_system0.96037592
133MP0005387_immune_system_phenotype0.96037592
134MP0002233_abnormal_nose_morphology0.95828933
135MP0005646_abnormal_pituitary_gland0.95459124
136MP0009384_cardiac_valve_regurgitation0.95375317
137MP0003984_embryonic_growth_retardation0.95140423
138MP0002088_abnormal_embryonic_growth/wei0.94185998
139MP0002736_abnormal_nociception_after0.93700175
140MP0002735_abnormal_chemical_nociception0.93034603
141MP0005390_skeleton_phenotype0.92635922
142MP0008058_abnormal_DNA_repair0.92399669
143MP0002080_prenatal_lethality0.91963234
144MP0004947_skin_inflammation0.89865105
145MP0004142_abnormal_muscle_tone0.89751439
146MP0005187_abnormal_penis_morphology0.89531797
147MP0003567_abnormal_fetal_cardiomyocyte0.89426296
148MP0001929_abnormal_gametogenesis0.89230189
149MP0005380_embryogenesis_phenotype0.89187871
150MP0001672_abnormal_embryogenesis/_devel0.89187871
151MP0005379_endocrine/exocrine_gland_phen0.87647619
152MP0009278_abnormal_bone_marrow0.87192909
153MP0003172_abnormal_lysosome_physiology0.86321103
154MP0004197_abnormal_fetal_growth/weight/0.85612895
155MP0002734_abnormal_mechanical_nocicepti0.84775600
156MP0001919_abnormal_reproductive_system0.84362030
157MP0001243_abnormal_dermal_layer0.84218787
158MP0005367_renal/urinary_system_phenotyp0.84201142
159MP0000516_abnormal_urinary_system0.84201142
160MP0001542_abnormal_bone_strength0.83445843
161MP0001853_heart_inflammation0.81392199
162MP0002009_preneoplasia0.80680511
163MP0000358_abnormal_cell_content/0.80158399
164MP0002184_abnormal_innervation0.79976988
165MP0001175_abnormal_lung_morphology0.79951486
166MP0005332_abnormal_amino_acid0.79140589
167MP0002229_neurodegeneration0.79070413
168MP0005391_vision/eye_phenotype0.79057285
169MP0003795_abnormal_bone_structure0.79054057
170MP0005389_reproductive_system_phenotype0.78881735
171MP0000371_diluted_coat_color0.78781952
172MP0005621_abnormal_cell_physiology0.78299224
173MP0002572_abnormal_emotion/affect_behav0.77832606
174MP0002234_abnormal_pharynx_morphology0.77660860
175MP0008057_abnormal_DNA_replication0.77374754
176MP0000313_abnormal_cell_death0.77162869
177MP0002938_white_spotting0.75983601
178MP0001324_abnormal_eye_pigmentation0.75591773
179MP0002210_abnormal_sex_determination0.75261251
180MP0000653_abnormal_sex_gland0.75148513
181MP0001177_atelectasis0.74914090
182MP0002882_abnormal_neuron_morphology0.74823546
183MP0000955_abnormal_spinal_cord0.74745563
184MP0002752_abnormal_somatic_nervous0.72928487
185MP0002069_abnormal_eating/drinking_beha0.70525380
186MP0003698_abnormal_male_reproductive0.70317984
187MP0003635_abnormal_synaptic_transmissio0.70045153
188MP0005195_abnormal_posterior_eye0.68963010
189MP0005365_abnormal_bile_salt0.68850100

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.62070283
2Ankle contracture (HP:0006466)4.09134035
3Papillary thyroid carcinoma (HP:0002895)3.78174671
4Cortical dysplasia (HP:0002539)3.37794328
5Cervical subluxation (HP:0003308)3.35173840
6Thrombocytosis (HP:0001894)3.21032228
7Abnormality of the labia minora (HP:0012880)3.20323963
8Vertebral compression fractures (HP:0002953)3.03587184
9Premature rupture of membranes (HP:0001788)3.01397059
10Volvulus (HP:0002580)3.01174779
11Thyroid carcinoma (HP:0002890)3.00063116
12Renal cortical cysts (HP:0000803)2.95112186
13Degeneration of anterior horn cells (HP:0002398)2.92948541
14Abnormality of the anterior horn cell (HP:0006802)2.92948541
15Medial flaring of the eyebrow (HP:0010747)2.92862980
16Hyperglycinemia (HP:0002154)2.89156945
17Aortic dissection (HP:0002647)2.87726350
18Aortic aneurysm (HP:0004942)2.80872603
19Gait imbalance (HP:0002141)2.75413606
20Dilatation of the ascending aorta (HP:0005111)2.73716654
21Nephrogenic diabetes insipidus (HP:0009806)2.73095925
22Congenital primary aphakia (HP:0007707)2.69737610
23Interstitial pulmonary disease (HP:0006530)2.69464161
24Amyotrophic lateral sclerosis (HP:0007354)2.68139728
25Spondylolisthesis (HP:0003302)2.65782116
26Vacuolated lymphocytes (HP:0001922)2.63015988
27Increased serum pyruvate (HP:0003542)2.61977234
28Lissencephaly (HP:0001339)2.61011393
29Drooling (HP:0002307)2.59774609
30Cerebral aneurysm (HP:0004944)2.57836164
31Hematochezia (HP:0002573)2.54956730
32Tubulointerstitial nephritis (HP:0001970)2.54893103
33Cutaneous melanoma (HP:0012056)2.51352702
34Abnormality of glycolysis (HP:0004366)2.51277890
35Birth length less than 3rd percentile (HP:0003561)2.47780184
36Eczematoid dermatitis (HP:0000976)2.46671381
37Generalized aminoaciduria (HP:0002909)2.42330208
38Methylmalonic acidemia (HP:0002912)2.42198234
39Recurrent abscess formation (HP:0002722)2.41271761
40Medulloblastoma (HP:0002885)2.40090428
41Elevated erythrocyte sedimentation rate (HP:0003565)2.38180466
42Hepatoblastoma (HP:0002884)2.37588404
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.37283990
44Osteolytic defects of the hand bones (HP:0009699)2.37283990
45Soft skin (HP:0000977)2.37216942
46Aplastic anemia (HP:0001915)2.33869967
47Subacute progressive viral hepatitis (HP:0006572)2.29997021
48Excessive salivation (HP:0003781)2.28865661
49Sensorimotor neuropathy (HP:0007141)2.28309947
50Atrophy/Degeneration involving motor neurons (HP:0007373)2.28168554
51Microvesicular hepatic steatosis (HP:0001414)2.28144507
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.26807640
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26807640
54Shallow orbits (HP:0000586)2.25952811
55Short tibia (HP:0005736)2.25730056
56Multiple enchondromatosis (HP:0005701)2.25332651
57Decreased skull ossification (HP:0004331)2.24582745
58Peritonitis (HP:0002586)2.24483369
59Limb dystonia (HP:0002451)2.24432389
60Vascular tortuosity (HP:0004948)2.24313704
61Autoimmune thrombocytopenia (HP:0001973)2.23211317
62Abnormality of the musculature of the pelvis (HP:0001469)2.20468308
63Abnormality of the hip-girdle musculature (HP:0001445)2.20468308
64Failure to thrive in infancy (HP:0001531)2.20128325
65Abnormality of glycine metabolism (HP:0010895)2.19478253
66Abnormality of serine family amino acid metabolism (HP:0010894)2.19478253
67Myositis (HP:0100614)2.19267299
68Abnormality of the corticospinal tract (HP:0002492)2.19070138
69Urinary urgency (HP:0000012)2.18855563
70Nonimmune hydrops fetalis (HP:0001790)2.18800003
71Pachygyria (HP:0001302)2.17841161
72Lipid accumulation in hepatocytes (HP:0006561)2.17274757
73Abnormal mitochondria in muscle tissue (HP:0008316)2.17213588
74Abnormality of skull ossification (HP:0002703)2.15983092
75Acute encephalopathy (HP:0006846)2.15467752
76Abnormality of macrophages (HP:0004311)2.15087937
77Increased CSF lactate (HP:0002490)2.14854561
78Colon cancer (HP:0003003)2.14255956
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.11617120
80Increased serum lactate (HP:0002151)2.11263702
81Retinal dysplasia (HP:0007973)2.10788367
82Genital tract atresia (HP:0001827)2.08019561
83Gonadotropin excess (HP:0000837)2.06720015
84Wrist flexion contracture (HP:0001239)2.06718236
85Broad palm (HP:0001169)2.06228053
86Biconcave vertebral bodies (HP:0004586)2.05210835
87Slender long bone (HP:0003100)2.05140608
88Postnatal microcephaly (HP:0005484)2.04295054
89T lymphocytopenia (HP:0005403)2.04177037
90Wormian bones (HP:0002645)2.03836386
91Hyperglycinuria (HP:0003108)2.03023363
92Polyphagia (HP:0002591)2.02790142
93Hypsarrhythmia (HP:0002521)2.02475591
94Impaired vibration sensation in the lower limbs (HP:0002166)2.01509929
953-Methylglutaconic aciduria (HP:0003535)2.01035344
96Abnormality of T cell number (HP:0011839)2.00301151
97Increased hepatocellular lipid droplets (HP:0006565)1.99599862
98Arterial tortuosity (HP:0005116)1.98512341
99Periodontitis (HP:0000704)1.98309580
100Termporal pattern (HP:0011008)1.97986587
101Insidious onset (HP:0003587)1.97986587
102Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97895639
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97895639
104Spinal cord lesions (HP:0100561)1.97513805
105Syringomyelia (HP:0003396)1.97513805
106Shoulder girdle muscle weakness (HP:0003547)1.96883713
107Vaginal atresia (HP:0000148)1.96832512
108Acute necrotizing encephalopathy (HP:0006965)1.95835494
109Entropion (HP:0000621)1.95531189
110Thin bony cortex (HP:0002753)1.95468583
111Broad face (HP:0000283)1.95344483
112Hepatic necrosis (HP:0002605)1.93052357
113Recurrent bacterial skin infections (HP:0005406)1.92726317
114IgM deficiency (HP:0002850)1.92404228
115Short 4th metacarpal (HP:0010044)1.92145849
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92145849
117Poor head control (HP:0002421)1.91402652
118Beaking of vertebral bodies (HP:0004568)1.89923850
119Lactic acidosis (HP:0003128)1.89483367
120Abnormality of T cells (HP:0002843)1.88711588
121Intestinal atresia (HP:0011100)1.88351624
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87744437
123Abnormality of alanine metabolism (HP:0010916)1.87744437
124Hyperalaninemia (HP:0003348)1.87744437
125Long clavicles (HP:0000890)1.87463310
126Abnormality of the distal phalanges of the toes (HP:0010182)1.87403441
127EEG with generalized epileptiform discharges (HP:0011198)1.87036645
128Abnormal biliary tract physiology (HP:0012439)1.86940591
129Bile duct proliferation (HP:0001408)1.86940591
130CNS demyelination (HP:0007305)1.86623648
131Hypothermia (HP:0002045)1.86555336
132Selective tooth agenesis (HP:0001592)1.86290284
133Abnormality of serum amino acid levels (HP:0003112)1.85938522
134Limb hypertonia (HP:0002509)1.85425932
135Abnormality of methionine metabolism (HP:0010901)1.84945070
136Thoracolumbar scoliosis (HP:0002944)1.84920322
137Spontaneous hematomas (HP:0007420)1.84548357
138Neoplasm of the adrenal gland (HP:0100631)1.84150458
139Recurrent viral infections (HP:0004429)1.83808537
140Deviation of the thumb (HP:0009603)1.83384982
141Cerebral edema (HP:0002181)1.82460683
142Mitochondrial inheritance (HP:0001427)1.80757725
143Agnosia (HP:0010524)1.80718327
144Hypoglycemic coma (HP:0001325)1.80098723
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79137656
146Muscular hypotonia of the trunk (HP:0008936)1.78897634
147Micronodular cirrhosis (HP:0001413)1.78737007
148Abolished electroretinogram (ERG) (HP:0000550)1.78700927
149Amaurosis fugax (HP:0100576)1.77729344
150Blue sclerae (HP:0000592)1.77610978
151Increased density of long bones (HP:0006392)1.77363842
152Specific learning disability (HP:0001328)1.77174583
153Abnormality of the calcaneus (HP:0008364)1.76468711
154Aneurysm (HP:0002617)1.74960305
155Pustule (HP:0200039)1.74850473
156Aortic valve stenosis (HP:0001650)1.74757161
157Metaphyseal cupping (HP:0003021)1.74596303
158Thyroid-stimulating hormone excess (HP:0002925)1.73741412
159Epileptiform EEG discharges (HP:0011182)1.73540269
160Methylmalonic aciduria (HP:0012120)1.73280470
161Progressive macrocephaly (HP:0004481)1.72749857
162Pancreatic cysts (HP:0001737)1.71485970
163Hypoplasia of the brainstem (HP:0002365)1.70117979
164Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70117979
165Increased intramyocellular lipid droplets (HP:0012240)1.69559986
166Epidermoid cyst (HP:0200040)1.69316923
167Abnormality of the renal cortex (HP:0011035)1.69147300
168Abnormality of the motor neurons (HP:0002450)1.69029073
169Abnormal neuron morphology (HP:0012757)1.69029073
170Proximal tubulopathy (HP:0000114)1.68859800
171Abnormality of the acetabulum (HP:0003170)1.68797831
172Hepatocellular necrosis (HP:0001404)1.68761309
173Morphological abnormality of the pyramidal tract (HP:0002062)1.68505644
174Pheochromocytoma (HP:0002666)1.68365716
175Recurrent fungal infections (HP:0002841)1.67965997
176Aortic regurgitation (HP:0001659)1.67154611
177Striae distensae (HP:0001065)1.66319844
178Arterial thrombosis (HP:0004420)1.65786946
179Platyspondyly (HP:0000926)1.63555701
180Long toe (HP:0010511)1.62871364
181Cellulitis (HP:0100658)1.62410736
182Delayed closure of the anterior fontanelle (HP:0001476)1.62282032
183Radial bowing (HP:0002986)1.62005418
184Recurrent bronchitis (HP:0002837)1.61731051
185Bladder diverticulum (HP:0000015)1.60642822
186Acute myeloid leukemia (HP:0004808)1.59747532
187Proximal placement of thumb (HP:0009623)1.59050203
188Lymphoma (HP:0002665)1.59020912
189Abnormality of the lumbar spine (HP:0100712)1.58656499
190Hand muscle atrophy (HP:0009130)1.58005328
191Leukocytosis (HP:0001974)1.57270737
192Abnormality of T cell physiology (HP:0011840)1.57105107
193Bowel diverticulosis (HP:0005222)1.57010416
194Bicuspid aortic valve (HP:0001647)1.56422035
195Mitral regurgitation (HP:0001653)1.56374516
196Missing ribs (HP:0000921)1.56077054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR4.25123536
2TRIM284.10708809
3MAP4K23.46765385
4ACVR1B3.17894539
5WNK32.56884141
6CSNK1G32.51204546
7CSNK1G22.49444570
8SCYL22.48009756
9MAP3K42.47560525
10PKN22.45805762
11TGFBR12.42577287
12MARK12.38111878
13FLT32.32391157
14EIF2AK12.32256236
15MAP2K72.31971441
16CSNK1A1L2.28643484
17CDC72.26410122
18ERN12.07554138
19CSNK1G12.06880318
20RPS6KA42.06125640
21STK102.04860468
22SRPK12.04342759
23MAP4K12.04177143
24TESK12.00141161
25PASK1.95888683
26TRIB31.88723298
27CCNB11.87557990
28STK161.86307481
29MINK11.81220573
30JAK31.81156574
31ZAP701.78550684
32MAPK131.75857836
33WEE11.70202378
34LRRK21.66234577
35MAP3K121.59068516
36PAK41.54918408
37TESK21.50340940
38TXK1.49985657
39BRSK21.49893394
40TYK21.49473492
41KIT1.44935295
42NEK21.43252239
43NEK91.41415827
44NME21.40335247
45KDR1.38819645
46EEF2K1.35028023
47DYRK21.31013508
48MST41.29875788
49PINK11.28863361
50EIF2AK31.27329521
51PIK3CG1.23336793
52MKNK11.22945938
53TBK11.22713096
54PLK21.22613853
55BUB11.20935669
56BCKDK1.20725641
57SIK31.20485696
58BMPR1B1.20312677
59LIMK11.19450361
60EPHA41.17943863
61PIM21.16012960
62RPS6KB21.14598149
63NUAK11.14194589
64TEC1.12279882
65CASK1.10919633
66BTK1.10573352
67VRK11.09931025
68NEK11.09482633
69ERBB31.04088053
70TGFBR21.02515704
71MAP3K81.02434463
72TTN1.01373669
73TSSK60.97979598
74STK30.92860617
75EPHA20.92685333
76MAP3K100.92608765
77PIM10.91564651
78MAP3K50.90461182
79BRD40.88465817
80MKNK20.88134137
81CAMKK20.87651336
82NLK0.86731307
83AURKB0.85124218
84STK38L0.84647387
85CHUK0.83610400
86FRK0.83191562
87STK240.82979271
88PAK30.82805857
89ITK0.82604576
90CSF1R0.82299998
91FGFR40.82253275
92JAK10.81980669
93IRAK40.81876047
94MELK0.81134015
95ATR0.79988304
96PLK40.79752658
97CDK190.79373326
98PDGFRA0.78582189
99PRKCG0.77975323
100PNCK0.77594614
101PRKCE0.77352750
102MAPKAPK30.75614704
103PLK10.75154018
104TTK0.74323187
105PTK60.74306481
106ZAK0.70665348
107STK40.69953185
108CDK70.69459382
109CDK140.69379575
110OXSR10.68768362
111LCK0.67866024
112PLK30.67603016
113LATS20.67309986
114IKBKE0.67292994
115FGFR30.66464150
116ILK0.66051747
117CDK40.65472272
118CDK60.64769002
119MARK30.64340737
120IKBKB0.62139331
121CSK0.61838675
122TRPM70.61136974
123PTK20.61072893
124MAP2K40.59585883
125MOS0.59323843
126EIF2AK20.57681585
127CDK180.57482571
128DYRK1B0.56720474
129EPHA30.55743253
130MAP2K30.54443049
131KSR10.52931238
132CAMK2A0.52837004
133PDK30.52697135
134PDK40.52697135
135ATM0.52518331
136RAF10.52467773
137RPS6KA50.50933852
138PAK20.50117511
139BLK0.48538596
140DAPK10.48100391
141CLK10.47906623
142ABL20.47617091
143PBK0.47502938
144LATS10.47389189
145BRSK10.47095297
146CSNK1A10.46508485
147YES10.46422506
148BMPR20.46071224
149PAK10.45958773
150PKN10.45866595
151TAOK30.45580015
152FGFR10.45492053
153MAP3K140.44431624
154STK390.44320101
155CDK150.43538250
156DYRK30.42634990
157CDK120.42355068
158GRK10.42208829
159CDK80.41995309
160CSNK1D0.41258575
161PDGFRB0.41178810
162JAK20.40072463
163PDK20.39729164
164CSNK2A10.39508730
165CDK11A0.38415924
166MAPKAPK50.38070329
167CSNK1E0.36795259
168MATK0.35429055
169UHMK10.34644373
170EGFR0.33087081
171PRKACB0.31054942
172CAMK2B0.30677901
173PRKACA0.30396743
174CDK50.30060821
175AURKA0.29886259

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.97874604
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82753468
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.71228345
4Propanoate metabolism_Homo sapiens_hsa006402.62697237
5DNA replication_Homo sapiens_hsa030302.46505811
6Butanoate metabolism_Homo sapiens_hsa006502.33823372
7Proteasome_Homo sapiens_hsa030502.29462108
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25666305
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23190546
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08539116
11Cell cycle_Homo sapiens_hsa041102.05272915
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00543235
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97968886
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96088095
15Legionellosis_Homo sapiens_hsa051341.95029018
16Leishmaniasis_Homo sapiens_hsa051401.94087885
17RNA transport_Homo sapiens_hsa030131.92687219
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89765333
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.89155210
20Antigen processing and presentation_Homo sapiens_hsa046121.87054640
21Fatty acid elongation_Homo sapiens_hsa000621.86362670
22Mismatch repair_Homo sapiens_hsa034301.78503147
23Oxidative phosphorylation_Homo sapiens_hsa001901.77854358
24Base excision repair_Homo sapiens_hsa034101.73813305
25Caffeine metabolism_Homo sapiens_hsa002321.71426273
26p53 signaling pathway_Homo sapiens_hsa041151.66835713
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.66241279
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65451191
29Parkinsons disease_Homo sapiens_hsa050121.62951308
30Shigellosis_Homo sapiens_hsa051311.62198238
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61898237
32Peroxisome_Homo sapiens_hsa041461.57192568
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54993357
34Spliceosome_Homo sapiens_hsa030401.54267550
35Measles_Homo sapiens_hsa051621.53531124
36Viral myocarditis_Homo sapiens_hsa054161.49536591
37Nucleotide excision repair_Homo sapiens_hsa034201.44926862
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43948567
39Fanconi anemia pathway_Homo sapiens_hsa034601.42922645
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39732445
41Sulfur metabolism_Homo sapiens_hsa009201.37988171
42Collecting duct acid secretion_Homo sapiens_hsa049661.33452541
43Herpes simplex infection_Homo sapiens_hsa051681.30740630
44Thyroid cancer_Homo sapiens_hsa052161.30477282
45Pyruvate metabolism_Homo sapiens_hsa006201.29610872
46Protein export_Homo sapiens_hsa030601.29327119
47Fatty acid metabolism_Homo sapiens_hsa012121.27871296
48Small cell lung cancer_Homo sapiens_hsa052221.27463536
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26062937
50Non-homologous end-joining_Homo sapiens_hsa034501.24983609
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.24552924
52Viral carcinogenesis_Homo sapiens_hsa052031.23585028
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22987341
54Phototransduction_Homo sapiens_hsa047441.22335082
55Toxoplasmosis_Homo sapiens_hsa051451.21946105
56Epstein-Barr virus infection_Homo sapiens_hsa051691.21478486
57beta-Alanine metabolism_Homo sapiens_hsa004101.20944447
58Homologous recombination_Homo sapiens_hsa034401.20786630
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.19820802
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.19505202
61Adherens junction_Homo sapiens_hsa045201.18729508
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.17337491
63Regulation of autophagy_Homo sapiens_hsa041401.17069421
64Apoptosis_Homo sapiens_hsa042101.15888205
65Primary immunodeficiency_Homo sapiens_hsa053401.15825252
66Carbon metabolism_Homo sapiens_hsa012001.15512650
67Chronic myeloid leukemia_Homo sapiens_hsa052201.15113579
68RNA polymerase_Homo sapiens_hsa030201.14581062
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14565077
70Fatty acid degradation_Homo sapiens_hsa000711.13077671
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11008391
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10903400
73Tryptophan metabolism_Homo sapiens_hsa003801.10505705
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10459345
75Pancreatic cancer_Homo sapiens_hsa052121.08919552
76Lysosome_Homo sapiens_hsa041421.07635696
77Malaria_Homo sapiens_hsa051441.06783171
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06004952
79Vibrio cholerae infection_Homo sapiens_hsa051101.05719904
80Hepatitis B_Homo sapiens_hsa051611.05617798
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05426768
82One carbon pool by folate_Homo sapiens_hsa006701.04604593
83Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03433067
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03389815
85Pyrimidine metabolism_Homo sapiens_hsa002401.01870147
86RNA degradation_Homo sapiens_hsa030181.00333141
87Oocyte meiosis_Homo sapiens_hsa041141.00144316
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99819516
89Other glycan degradation_Homo sapiens_hsa005110.99451437
90HTLV-I infection_Homo sapiens_hsa051660.98914883
91Osteoclast differentiation_Homo sapiens_hsa043800.98505535
92Pertussis_Homo sapiens_hsa051330.98220438
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.98170662
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97947597
95Pentose phosphate pathway_Homo sapiens_hsa000300.97029136
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96681384
97Nicotine addiction_Homo sapiens_hsa050330.96353108
98Retinol metabolism_Homo sapiens_hsa008300.95888506
99Colorectal cancer_Homo sapiens_hsa052100.95616765
100Influenza A_Homo sapiens_hsa051640.95544554
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95221700
102N-Glycan biosynthesis_Homo sapiens_hsa005100.93799424
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92412585
104Asthma_Homo sapiens_hsa053100.92383145
105Selenocompound metabolism_Homo sapiens_hsa004500.90394972
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.90298029
107Salmonella infection_Homo sapiens_hsa051320.89925029
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89900507
109Huntingtons disease_Homo sapiens_hsa050160.89591871
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89015681
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88748150
112Circadian rhythm_Homo sapiens_hsa047100.87189965
113Focal adhesion_Homo sapiens_hsa045100.86459172
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.85815900
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85369106
116Biosynthesis of amino acids_Homo sapiens_hsa012300.83858140
117B cell receptor signaling pathway_Homo sapiens_hsa046620.83563964
118Hematopoietic cell lineage_Homo sapiens_hsa046400.83499675
119Phagosome_Homo sapiens_hsa041450.82589488
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82441086
121Graft-versus-host disease_Homo sapiens_hsa053320.81851156
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.81489913
123TNF signaling pathway_Homo sapiens_hsa046680.81201035
124Renin-angiotensin system_Homo sapiens_hsa046140.81026233
125Ribosome_Homo sapiens_hsa030100.80928006
126Proteoglycans in cancer_Homo sapiens_hsa052050.80915415
127MicroRNAs in cancer_Homo sapiens_hsa052060.80674060
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.80387557
129Amoebiasis_Homo sapiens_hsa051460.79527932
130Tuberculosis_Homo sapiens_hsa051520.79175667
131GABAergic synapse_Homo sapiens_hsa047270.79120992
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78913556
133mRNA surveillance pathway_Homo sapiens_hsa030150.78608156
134Chemical carcinogenesis_Homo sapiens_hsa052040.78275099
135Allograft rejection_Homo sapiens_hsa053300.78250554
136T cell receptor signaling pathway_Homo sapiens_hsa046600.78030520
137Acute myeloid leukemia_Homo sapiens_hsa052210.76280436
138Alzheimers disease_Homo sapiens_hsa050100.76092393
139Synaptic vesicle cycle_Homo sapiens_hsa047210.75322375
140Arginine biosynthesis_Homo sapiens_hsa002200.74848581
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74253986
142ECM-receptor interaction_Homo sapiens_hsa045120.74040713
143TGF-beta signaling pathway_Homo sapiens_hsa043500.72674504
144Arginine and proline metabolism_Homo sapiens_hsa003300.69319828
145Basal transcription factors_Homo sapiens_hsa030220.68328634
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67046312
147Metabolic pathways_Homo sapiens_hsa011000.66403533
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63451956
149Platelet activation_Homo sapiens_hsa046110.63129076
150Galactose metabolism_Homo sapiens_hsa000520.62712632
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62647129
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59597640
153Bladder cancer_Homo sapiens_hsa052190.58870438
154Dopaminergic synapse_Homo sapiens_hsa047280.58733018
155Prolactin signaling pathway_Homo sapiens_hsa049170.58283235
156Endometrial cancer_Homo sapiens_hsa052130.57494106
157Alcoholism_Homo sapiens_hsa050340.57309450
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.56746724
159Neurotrophin signaling pathway_Homo sapiens_hsa047220.55547740
160Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53717656
161HIF-1 signaling pathway_Homo sapiens_hsa040660.52362094
162Prostate cancer_Homo sapiens_hsa052150.51990083
163Tyrosine metabolism_Homo sapiens_hsa003500.51743181
164mTOR signaling pathway_Homo sapiens_hsa041500.51518914
165Phenylalanine metabolism_Homo sapiens_hsa003600.48191315
166Systemic lupus erythematosus_Homo sapiens_hsa053220.46042443
167Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42489882
168Rheumatoid arthritis_Homo sapiens_hsa053230.41795658
169Type I diabetes mellitus_Homo sapiens_hsa049400.40627067
170Linoleic acid metabolism_Homo sapiens_hsa005910.40445589
171Folate biosynthesis_Homo sapiens_hsa007900.38481965
172Starch and sucrose metabolism_Homo sapiens_hsa005000.37465829
173Sphingolipid metabolism_Homo sapiens_hsa006000.36517398
174PPAR signaling pathway_Homo sapiens_hsa033200.33548163
175Amphetamine addiction_Homo sapiens_hsa050310.32555816
176Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32461522
177Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32293922
178Purine metabolism_Homo sapiens_hsa002300.32180883
179Ether lipid metabolism_Homo sapiens_hsa005650.30594202

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