SNX33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.71103067
2desmosome organization (GO:0002934)4.93671820
3cell-substrate junction assembly (GO:0007044)4.26777701
4axon ensheathment in central nervous system (GO:0032291)4.03018936
5central nervous system myelination (GO:0022010)4.03018936
6myelin maintenance (GO:0043217)3.92751687
7alpha-linolenic acid metabolic process (GO:0036109)3.88844049
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.83190410
9basement membrane organization (GO:0071711)3.68150994
10fatty acid elongation (GO:0030497)3.60967722
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.52745383
12regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.46467030
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43844657
14L-phenylalanine catabolic process (GO:0006559)3.43844657
15surfactant homeostasis (GO:0043129)3.39662621
16adherens junction assembly (GO:0034333)3.38043897
17vascular endothelial growth factor signaling pathway (GO:0038084)3.37085514
18adhesion of symbiont to host cell (GO:0044650)3.36026322
19virion attachment to host cell (GO:0019062)3.36026322
20epithelial cell-cell adhesion (GO:0090136)3.34267957
21cell-substrate adherens junction assembly (GO:0007045)3.30318431
22focal adhesion assembly (GO:0048041)3.30318431
23bundle of His cell to Purkinje myocyte communication (GO:0086069)3.27930015
24COPI coating of Golgi vesicle (GO:0048205)3.27008221
25Golgi transport vesicle coating (GO:0048200)3.27008221
26ensheathment of neurons (GO:0007272)3.17319285
27axon ensheathment (GO:0008366)3.17319285
28myelination (GO:0042552)3.15965276
29dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.13477111
30adhesion of symbiont to host (GO:0044406)3.09883623
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.04846726
32L-phenylalanine metabolic process (GO:0006558)3.04846726
33creatine metabolic process (GO:0006600)2.99176108
34semaphorin-plexin signaling pathway (GO:0071526)2.98068355
35atrioventricular valve morphogenesis (GO:0003181)2.97950960
36response to lipoprotein particle (GO:0055094)2.97456350
37positive regulation of fatty acid beta-oxidation (GO:0032000)2.97287495
38barbed-end actin filament capping (GO:0051016)2.97178438
39endothelial cell chemotaxis (GO:0035767)2.96524371
40cytoskeletal anchoring at plasma membrane (GO:0007016)2.96029832
41negative regulation of chondrocyte differentiation (GO:0032331)2.93165939
42cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.92271477
43very long-chain fatty acid metabolic process (GO:0000038)2.91577093
44regulation of extracellular matrix disassembly (GO:0010715)2.90811487
45protein retention in ER lumen (GO:0006621)2.90224105
46peripheral nervous system axon ensheathment (GO:0032292)2.88255452
47myelination in peripheral nervous system (GO:0022011)2.88255452
48cell migration involved in heart development (GO:0060973)2.88234721
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87965922
50collagen metabolic process (GO:0032963)2.86640978
51positive regulation of endothelial cell apoptotic process (GO:2000353)2.84267554
52apoptotic cell clearance (GO:0043277)2.84069359
53extracellular matrix disassembly (GO:0022617)2.82571113
54regulation of water loss via skin (GO:0033561)2.81488314
55regulation of cholesterol biosynthetic process (GO:0045540)2.80548542
56regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80512709
57multicellular organismal macromolecule metabolic process (GO:0044259)2.77773134
58type B pancreatic cell proliferation (GO:0044342)2.75269225
59negative regulation of fibrinolysis (GO:0051918)2.73959370
60growth hormone receptor signaling pathway (GO:0060396)2.73950327
61protein carboxylation (GO:0018214)2.73710194
62peptidyl-glutamic acid carboxylation (GO:0017187)2.73710194
63lateral sprouting from an epithelium (GO:0060601)2.73145465
64extracellular fibril organization (GO:0043206)2.72377295
65prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.71847471
66glomerular filtration (GO:0003094)2.71226899
67reverse cholesterol transport (GO:0043691)2.70574477
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.68348596
69collagen catabolic process (GO:0030574)2.67369838
70positive regulation of extracellular matrix organization (GO:1903055)2.67177218
71long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.66812772
72multicellular organismal metabolic process (GO:0044236)2.65671666
73positive regulation of blood vessel endothelial cell migration (GO:0043536)2.63732157
74vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.63711500
75stress fiber assembly (GO:0043149)2.61523536
76peptidyl-proline hydroxylation (GO:0019511)2.60631970
77renal filtration (GO:0097205)2.60318832
78midgut development (GO:0007494)2.60283138
79negative regulation of smooth muscle cell migration (GO:0014912)2.59521465
80membrane protein ectodomain proteolysis (GO:0006509)2.59291659
81insulin-like growth factor receptor signaling pathway (GO:0048009)2.59054659
82fatty-acyl-CoA biosynthetic process (GO:0046949)2.58821917
83response to follicle-stimulating hormone (GO:0032354)2.58034492
84regulation of early endosome to late endosome transport (GO:2000641)2.56802805
85cell migration involved in sprouting angiogenesis (GO:0002042)2.55477004
86multicellular organismal catabolic process (GO:0044243)2.55436030
87regulation of establishment of planar polarity (GO:0090175)2.54809963
88paraxial mesoderm development (GO:0048339)2.54543452
89fibril organization (GO:0097435)2.52462140
90regulation of cholesterol metabolic process (GO:0090181)2.52440891
91establishment of skin barrier (GO:0061436)2.52253413
92collagen fibril organization (GO:0030199)2.51869242
93lung lobe morphogenesis (GO:0060463)2.51238507
94embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50809749
95hypotonic response (GO:0006971)2.50566848
96interleukin-6-mediated signaling pathway (GO:0070102)2.50492719
97chemical homeostasis within a tissue (GO:0048875)2.50219130
98plasma lipoprotein particle clearance (GO:0034381)2.49982292
99regulation of apoptotic cell clearance (GO:2000425)2.48674432
100bile acid biosynthetic process (GO:0006699)2.47895699
101positive regulation of fatty acid oxidation (GO:0046321)2.46817789
102sulfur amino acid catabolic process (GO:0000098)2.45545743
103protein localization to endosome (GO:0036010)2.45514345
104regulation of glucose import in response to insulin stimulus (GO:2001273)2.44126992
105retina vasculature morphogenesis in camera-type eye (GO:0061299)2.43166547
106purine ribonucleotide transport (GO:0015868)2.42844984
107branching involved in mammary gland duct morphogenesis (GO:0060444)2.42334375
108fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.42088514
109astrocyte development (GO:0014002)2.42042474
110regulation of lipoprotein metabolic process (GO:0050746)2.41647378
111extracellular matrix organization (GO:0030198)2.41638395
112cell adhesion mediated by integrin (GO:0033627)2.41572243
113cellular response to growth hormone stimulus (GO:0071378)2.41343286
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.41065957
115extracellular structure organization (GO:0043062)2.40589714
116endothelial cell morphogenesis (GO:0001886)2.39921703
117wound healing, spreading of epidermal cells (GO:0035313)2.37792259
118L-serine transport (GO:0015825)2.37558273
119blood vessel endothelial cell migration (GO:0043534)2.37422259
120mesodermal cell differentiation (GO:0048333)2.37016841
121negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.36943973
122branching involved in salivary gland morphogenesis (GO:0060445)2.36594446
123embryo implantation (GO:0007566)2.35398240
124negative regulation of keratinocyte proliferation (GO:0010839)2.35350644
125high-density lipoprotein particle remodeling (GO:0034375)2.35085846
126hyaluronan catabolic process (GO:0030214)2.34866194
127regulation of cholesterol esterification (GO:0010872)2.34628863
128aromatic amino acid family catabolic process (GO:0009074)2.34558564
129cochlea morphogenesis (GO:0090103)2.33055452
130gap junction assembly (GO:0016264)2.32628473
131endocytic recycling (GO:0032456)2.31220957
132negative regulation of fatty acid transport (GO:2000192)2.30964820
133regulation of fatty acid beta-oxidation (GO:0031998)2.30062764
134cellular response to cholesterol (GO:0071397)2.29865107
135regulation of fibrinolysis (GO:0051917)2.29069506
136extracellular matrix assembly (GO:0085029)2.28680455
137protein hydroxylation (GO:0018126)2.28629332
138axon extension involved in axon guidance (GO:0048846)2.28384745
139neuron projection extension involved in neuron projection guidance (GO:1902284)2.28384745
140protein heterotrimerization (GO:0070208)2.28323205
141multicellular organismal water homeostasis (GO:0050891)2.28204044
142regulation of extracellular matrix organization (GO:1903053)2.28147664
143opsonization (GO:0008228)2.27727696
144low-density lipoprotein particle clearance (GO:0034383)2.27163798
145cell junction assembly (GO:0034329)2.27063249
146response to nitrosative stress (GO:0051409)2.26310882
147phospholipid homeostasis (GO:0055091)2.25516646
148regulation of plasminogen activation (GO:0010755)2.25385529
149regulation of cholesterol homeostasis (GO:2000188)2.24541604
150purine nucleotide transport (GO:0015865)2.22624902
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.22542405
152membrane raft organization (GO:0031579)2.22373238
153endocardial cushion development (GO:0003197)2.21996364
154regulation of protein activation cascade (GO:2000257)2.21809690
155pathway-restricted SMAD protein phosphorylation (GO:0060389)2.21575344
156positive regulation of astrocyte differentiation (GO:0048711)2.21499740
157cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.20931922
158chondrocyte proliferation (GO:0035988)2.20898448
159amyloid precursor protein catabolic process (GO:0042987)2.20711341
160glomerular basement membrane development (GO:0032836)2.20642545
161endodermal cell differentiation (GO:0035987)2.20635378
162skin morphogenesis (GO:0043589)2.20383995
163definitive hemopoiesis (GO:0060216)2.20017022
164heme transport (GO:0015886)2.19883156
165tyrosine metabolic process (GO:0006570)2.19815411
166positive regulation of osteoblast proliferation (GO:0033690)2.19710080
167complement activation, alternative pathway (GO:0006957)2.19414295
168fatty-acyl-CoA metabolic process (GO:0035337)2.16937212
169positive regulation of p38MAPK cascade (GO:1900745)2.16098000
170positive regulation of blood coagulation (GO:0030194)2.15663705
171positive regulation of hemostasis (GO:1900048)2.15663705
172positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.15532450
173regulation of complement activation (GO:0030449)2.15526514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.26353675
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.42226256
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.14184140
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.01036715
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.00991771
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.77034348
7CLOCK_20551151_ChIP-Seq_293T_Human2.76662249
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.70443941
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68435079
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.53362747
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23983343
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22259551
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.19703604
14ZNF263_19887448_ChIP-Seq_K562_Human2.08193386
15* RACK7_27058665_Chip-Seq_MCF-7_Human2.06572404
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95957791
17* LXR_22292898_ChIP-Seq_THP-1_Human1.95753699
18FOXO3_23340844_ChIP-Seq_DLD1_Human1.91006736
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90794539
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.89609517
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86913661
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84263894
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82177193
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.80536579
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79997553
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79997553
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79964726
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77999534
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77891817
30* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75432503
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.75057726
32* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71493463
33* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67591665
34* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66989248
35CJUN_26792858_Chip-Seq_BT549_Human1.66816437
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.64575108
37KDM2B_26808549_Chip-Seq_K562_Human1.62217163
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61150570
39* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57838968
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.54522535
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54207322
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52325819
43AR_21572438_ChIP-Seq_LNCaP_Human1.52178461
44RUNX_20019798_ChIP-Seq_JUKART_Human1.51123315
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49004968
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.48583745
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46299109
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45901691
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44625816
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43607333
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43495491
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.43466247
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41392562
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40716640
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.40640150
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39536951
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39244838
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36481141
59* TBX20_22080862_ChIP-Seq_HEART_Mouse1.35732822
60* TBX20_22328084_ChIP-Seq_HEART_Mouse1.35732822
61SOX2_20726797_ChIP-Seq_SW620_Human1.35529029
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34476660
63ATF3_27146783_Chip-Seq_COLON_Human1.34254691
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33194769
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27996653
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.27932522
67* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27526855
68TP53_22127205_ChIP-Seq_IMR90_Human1.27492787
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24596471
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23180158
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19753365
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19513302
73TP53_16413492_ChIP-PET_HCT116_Human1.18310866
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17695941
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14521523
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13899910
77TCF7_22412390_ChIP-Seq_EML_Mouse1.13328541
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12564563
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12564563
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12177666
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11760929
82VDR_24787735_ChIP-Seq_THP-1_Human1.11254029
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10773550
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.10230433
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10092244
86* KDM2B_26808549_Chip-Seq_DND41_Human1.10082072
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09913465
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09463049
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07478074
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07285897
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06630338
92CDX2_20551321_ChIP-Seq_CACO-2_Human1.05545549
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05250969
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04831731
95TP53_18474530_ChIP-ChIP_U2OS_Human1.04269635
96* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04187475
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03224010
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03063201
99* ELK3_25401928_ChIP-Seq_HUVEC_Human1.02690353
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02590375
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01824618
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01447127
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01338150
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01317615
105AHR_22903824_ChIP-Seq_MCF-7_Human1.00159430
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00143657
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99409473
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.98584736
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98201541
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.97748446
111EED_16625203_ChIP-ChIP_MESCs_Mouse0.97508164
112IRF8_22096565_ChIP-ChIP_GC-B_Human0.97285302
113TP53_23651856_ChIP-Seq_MEFs_Mouse0.97045399
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96162363
115GATA1_19941826_ChIP-Seq_K562_Human0.95819021
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95737256
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95337578
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.94982593
119* CREB1_26743006_Chip-Seq_LNCaP_Human0.94475326
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93889130
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93853526
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93104096
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93052967
124TP63_22573176_ChIP-Seq_HFKS_Human0.92421995
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92106338
126* TP63_23658742_ChIP-Seq_EP156T_Human0.92009360
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.91794032
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91741248
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90820262
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90791760
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90533106
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90053901
133* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89850287
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89671334
135GATA4_25053715_ChIP-Seq_YYC3_Human0.89276790
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.89041668
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89006960
138* BRD4_25478319_ChIP-Seq_HGPS_Human0.87466329
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86440564
140BP1_19119308_ChIP-ChIP_Hs578T_Human0.86088975
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85704063
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84452169
143* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84211309
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83608516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.57851291
2MP0005275_abnormal_skin_tensile2.98318923
3MP0005257_abnormal_intraocular_pressure2.72541393
4MP0009384_cardiac_valve_regurgitation2.64768038
5MP0001958_emphysema2.63893642
6MP0004272_abnormal_basement_membrane2.61395477
7MP0003705_abnormal_hypodermis_morpholog2.58308666
8MP0003279_aneurysm2.56341193
9MP0005503_abnormal_tendon_morphology2.52590907
10MP0002139_abnormal_hepatobiliary_system2.40085943
11MP0003941_abnormal_skin_development2.36837347
12MP0000566_synostosis2.30856826
13MP0002796_impaired_skin_barrier2.28974346
14MP0005171_absent_coat_pigmentation2.25082209
15MP0000920_abnormal_myelination2.17777374
16MP0005409_darkened_coat_color2.10895050
17MP0005360_urolithiasis2.06170316
18MP0000383_abnormal_hair_follicle2.04975472
19MP0005365_abnormal_bile_salt2.02904513
20MP0000579_abnormal_nail_morphology2.01111338
21MP0001849_ear_inflammation1.98614632
22MP0009840_abnormal_foam_cell1.97936090
23MP0003690_abnormal_glial_cell1.96688146
24MP0010678_abnormal_skin_adnexa1.95230630
25MP0005623_abnormal_meninges_morphology1.92783020
26MP0003950_abnormal_plasma_membrane1.86599928
27MP0006054_spinal_hemorrhage1.84630508
28MP0004858_abnormal_nervous_system1.73147353
29MP0003252_abnormal_bile_duct1.71975680
30MP0010352_gastrointestinal_tract_polyps1.69304466
31MP0003806_abnormal_nucleotide_metabolis1.69184436
32MP0005085_abnormal_gallbladder_physiolo1.66077372
33MP0003566_abnormal_cell_adhesion1.65611105
34MP0010368_abnormal_lymphatic_system1.65451275
35MP0005083_abnormal_biliary_tract1.63957639
36MP0000751_myopathy1.53828437
37MP0005076_abnormal_cell_differentiation1.52566031
38MP0003300_gastrointestinal_ulcer1.47386506
39MP0002295_abnormal_pulmonary_circulatio1.47169249
40MP0002060_abnormal_skin_morphology1.45704312
41MP0005501_abnormal_skin_physiology1.45621215
42MP0009780_abnormal_chondrocyte_physiolo1.43753557
43MP0005408_hypopigmentation1.42389143
44MP0005508_abnormal_skeleton_morphology1.41771071
45MP0005023_abnormal_wound_healing1.40442980
46MP0005670_abnormal_white_adipose1.40124314
47MP0003091_abnormal_cell_migration1.39304725
48MP0008875_abnormal_xenobiotic_pharmacok1.36770127
49MP0002254_reproductive_system_inflammat1.36224741
50MP0004134_abnormal_chest_morphology1.31536614
51MP0009250_abnormal_appendicular_skeleto1.30272048
52MP0003453_abnormal_keratinocyte_physiol1.27085161
53MP0000767_abnormal_smooth_muscle1.25488203
54MP0000733_abnormal_muscle_development1.23630568
55MP0010329_abnormal_lipoprotein_level1.21076752
56MP0001216_abnormal_epidermal_layer1.18367724
57MP0005451_abnormal_body_composition1.16148587
58MP0004185_abnormal_adipocyte_glucose1.14927302
59MP0004264_abnormal_extraembryonic_tissu1.14355574
60MP0002089_abnormal_postnatal_growth/wei1.13542523
61MP0001243_abnormal_dermal_layer1.13146080
62MP0003329_amyloid_beta_deposits1.12231755
63MP0000003_abnormal_adipose_tissue1.10680523
64MP0005058_abnormal_lysosome_morphology1.09215878
65MP0005595_abnormal_vascular_smooth1.08990454
66MP0005666_abnormal_adipose_tissue1.08218918
67MP0003191_abnormal_cellular_cholesterol1.06917025
68MP0000604_amyloidosis1.06213292
69MP0002168_other_aberrant_phenotype1.06060258
70MP0002933_joint_inflammation1.05089534
71MP0001299_abnormal_eye_distance/1.04877567
72MP0004147_increased_porphyrin_level1.04752974
73MP0000534_abnormal_ureter_morphology1.03427529
74MP0001661_extended_life_span1.02796005
75MP0000678_abnormal_parathyroid_gland1.02232746
76MP0001666_abnormal_nutrient_absorption1.00896591
77MP0003045_fibrosis1.00080498
78MP0009053_abnormal_anal_canal0.99119890
79MP0002118_abnormal_lipid_homeostasis0.98964733
80MP0000537_abnormal_urethra_morphology0.98368275
81MP0010771_integument_phenotype0.97238473
82MP0000013_abnormal_adipose_tissue0.97195096
83MP0004782_abnormal_surfactant_physiolog0.97153558
84MP0003195_calcinosis0.96902902
85MP0003942_abnormal_urinary_system0.96772564
86MP0001542_abnormal_bone_strength0.95713696
87MP0001879_abnormal_lymphatic_vessel0.95707309
88MP0003385_abnormal_body_wall0.94047094
89MP0005332_abnormal_amino_acid0.93639164
90MP0010030_abnormal_orbit_morphology0.91651011
91MP0000647_abnormal_sebaceous_gland0.90615064
92MP0000163_abnormal_cartilage_morphology0.89729725
93MP0001346_abnormal_lacrimal_gland0.89157053
94MP0004381_abnormal_hair_follicle0.88108814
95MP0002108_abnormal_muscle_morphology0.87979247
96MP0000428_abnormal_craniofacial_morphol0.86181043
97MP0002115_abnormal_skeleton_extremities0.85854910
98MP0001614_abnormal_blood_vessel0.85189472
99MP0000762_abnormal_tongue_morphology0.85114487
100MP0003724_increased_susceptibility_to0.85084065
101MP0001915_intracranial_hemorrhage0.84970191
102MP0003115_abnormal_respiratory_system0.83349478
103MP0002282_abnormal_trachea_morphology0.82630321
104MP0000462_abnormal_digestive_system0.82277171
105MP0003937_abnormal_limbs/digits/tail_de0.81677420
106MP0002128_abnormal_blood_circulation0.81149846
107MP0002133_abnormal_respiratory_system0.81048888
108MP0005388_respiratory_system_phenotype0.81048888
109MP0005375_adipose_tissue_phenotype0.79571350
110MP0002098_abnormal_vibrissa_morphology0.78880689
111MP0006138_congestive_heart_failure0.77854836
112MP0000377_abnormal_hair_follicle0.77108437
113MP0010234_abnormal_vibrissa_follicle0.76923836
114MP0000609_abnormal_liver_physiology0.76611926
115MP0002249_abnormal_larynx_morphology0.76130636
116MP0009764_decreased_sensitivity_to0.76050766
117MP0000467_abnormal_esophagus_morphology0.76039848
118MP0005390_skeleton_phenotype0.75828768
119MP0002925_abnormal_cardiovascular_devel0.75543806
120MP0004233_abnormal_muscle_weight0.75415644
121MP0001177_atelectasis0.75174058
122MP0009931_abnormal_skin_appearance0.75036720
123MP0002932_abnormal_joint_morphology0.74498286
124MP0004130_abnormal_muscle_cell0.73446141
125MP0005197_abnormal_uvea_morphology0.73165598
126MP0002896_abnormal_bone_mineralization0.72619717
127MP0000858_altered_metastatic_potential0.71739477
128MP0003634_abnormal_glial_cell0.71287150
129MP0000432_abnormal_head_morphology0.70588792
130MP0001851_eye_inflammation0.70482019
131MP0005164_abnormal_response_to0.70120640
132MP0002877_abnormal_melanocyte_morpholog0.69145831
133MP0002998_abnormal_bone_remodeling0.67811836
134MP0010630_abnormal_cardiac_muscle0.66299650
135MP0005165_increased_susceptibility_to0.65306191
136MP0004947_skin_inflammation0.65112737
137MP0003448_altered_tumor_morphology0.65062664
138MP0000759_abnormal_skeletal_muscle0.64906533

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.91379672
2Broad metatarsal (HP:0001783)4.25967396
3Protrusio acetabuli (HP:0003179)4.13846617
4Aortic dissection (HP:0002647)3.60845327
5Deep venous thrombosis (HP:0002625)3.54030822
6Shallow orbits (HP:0000586)3.08521204
7Coronal craniosynostosis (HP:0004440)3.08472108
8Aortic aneurysm (HP:0004942)3.08239022
9Neurofibrillary tangles (HP:0002185)3.02742876
10Aplasia involving bones of the upper limbs (HP:0009823)2.95372061
11Aplasia of the phalanges of the hand (HP:0009802)2.95372061
12Aplasia involving bones of the extremities (HP:0009825)2.95372061
13Xanthomatosis (HP:0000991)2.86693020
14Abnormality of the middle phalanges of the toes (HP:0010183)2.81879339
15Follicular hyperkeratosis (HP:0007502)2.79792464
16Intrahepatic cholestasis (HP:0001406)2.75855301
17Short hallux (HP:0010109)2.75575985
18Advanced eruption of teeth (HP:0006288)2.74620505
19Thick nail (HP:0001805)2.69378913
20Atrophic scars (HP:0001075)2.68508350
21Osteolytic defects of the hand bones (HP:0009699)2.67979840
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.67979840
23Abnormality of the phalanges of the 2nd finger (HP:0009541)2.67634983
24Natal tooth (HP:0000695)2.63885564
25Infantile muscular hypotonia (HP:0008947)2.57945843
26Hypoalphalipoproteinemia (HP:0003233)2.56729069
27Ankle contracture (HP:0006466)2.56632072
28Premature skin wrinkling (HP:0100678)2.54061328
29Ulnar bowing (HP:0003031)2.51871874
30Stridor (HP:0010307)2.51687774
31Blue sclerae (HP:0000592)2.50254846
32Abnormality of nail color (HP:0100643)2.48517276
33Mildly elevated creatine phosphokinase (HP:0008180)2.45674686
34Aplasia/Hypoplasia of the hallux (HP:0008362)2.41372940
35Milia (HP:0001056)2.38814640
36Abnormality of dentin (HP:0010299)2.37879234
37Soft skin (HP:0000977)2.36818093
38Peritonitis (HP:0002586)2.33797132
39Hyperlipoproteinemia (HP:0010980)2.33693079
40Thin bony cortex (HP:0002753)2.33609733
41Abnormality of the 2nd finger (HP:0004100)2.33372071
42Cerebral inclusion bodies (HP:0100314)2.29287943
43Biconcave vertebral bodies (HP:0004586)2.28124041
44Bladder diverticulum (HP:0000015)2.26417198
45Mitral valve prolapse (HP:0001634)2.23075248
46Joint laxity (HP:0001388)2.22577857
47Wormian bones (HP:0002645)2.22396454
48Hypoplasia of the iris (HP:0007676)2.22008778
49Increased variability in muscle fiber diameter (HP:0003557)2.21786739
50Bell-shaped thorax (HP:0001591)2.21120342
51Genu recurvatum (HP:0002816)2.18345916
52Mitral stenosis (HP:0001718)2.18198125
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16835378
54Myocardial infarction (HP:0001658)2.15698458
55Abnormality of the common coagulation pathway (HP:0010990)2.14240222
56Wide anterior fontanel (HP:0000260)2.14094375
57Flat acetabular roof (HP:0003180)2.12762535
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.12472630
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12472630
60Abnormality of the acetabulum (HP:0003170)2.12426911
61Hyperacusis (HP:0010780)2.12160869
62Mitral regurgitation (HP:0001653)2.11064080
63Alopecia of scalp (HP:0002293)2.10759887
64Cerebral aneurysm (HP:0004944)2.10347775
65Broad face (HP:0000283)2.07129236
66Neonatal short-limb short stature (HP:0008921)2.07118288
67Scapular winging (HP:0003691)2.06039136
68Hyperextensible skin (HP:0000974)2.05845155
69Cardiovascular calcification (HP:0011915)2.04556325
70Abnormality of complement system (HP:0005339)2.04522423
71Elbow flexion contracture (HP:0002987)2.03926100
72Turricephaly (HP:0000262)2.03654127
73Pterygium (HP:0001059)2.01746395
74Bowing of the arm (HP:0006488)2.00374335
75Bowed forearm bones (HP:0003956)2.00374335
76Disproportionate tall stature (HP:0001519)2.00041312
77Spondylolisthesis (HP:0003302)1.99952526
78Ectopia lentis (HP:0001083)1.99877774
79Abnormality of carpal bone ossification (HP:0006257)1.99198718
80Distal upper limb amyotrophy (HP:0007149)1.98446198
81Upper limb amyotrophy (HP:0009129)1.98446198
82Abnormal ossification of hand bones (HP:0005921)1.97722851
83Deviation of the hallux (HP:0010051)1.97003984
84Complement deficiency (HP:0004431)1.96849719
85Aortic regurgitation (HP:0001659)1.96573148
86Hallux valgus (HP:0001822)1.94910950
87Spinal rigidity (HP:0003306)1.94652695
88Distal lower limb muscle weakness (HP:0009053)1.94168672
89Fragile skin (HP:0001030)1.94103290
90Back pain (HP:0003418)1.93989832
91Overgrowth (HP:0001548)1.93985126
92Achilles tendon contracture (HP:0001771)1.91917218
93Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91142980
94Femoral bowing (HP:0002980)1.90684251
95Dilatation of the ascending aorta (HP:0005111)1.89939007
96Vascular tortuosity (HP:0004948)1.89579048
97Hypolipoproteinemia (HP:0010981)1.88394080
98Fragile nails (HP:0001808)1.87542706
99Distal lower limb amyotrophy (HP:0008944)1.86329131
100Tarsal synostosis (HP:0008368)1.86268538
101Obstructive sleep apnea (HP:0002870)1.85527086
102Abnormality of skeletal muscle fiber size (HP:0012084)1.83404949
103Type 1 muscle fiber predominance (HP:0003803)1.82735507
104Cervical subluxation (HP:0003308)1.82684837
105Buphthalmos (HP:0000557)1.82568263
106Abnormality of the Achilles tendon (HP:0005109)1.82511650
107Short nail (HP:0001799)1.81928217
108Aneurysm (HP:0002617)1.81396483
109Hyporeflexia of lower limbs (HP:0002600)1.79087906
110Increased connective tissue (HP:0009025)1.79076915
111Plantar hyperkeratosis (HP:0007556)1.79058091
112Asymmetry of the thorax (HP:0001555)1.78699004
113Slender build (HP:0001533)1.78576868
114Coxa vara (HP:0002812)1.75994396
115Mesomelia (HP:0003027)1.75857478
116Syringomyelia (HP:0003396)1.75698861
117Spinal cord lesions (HP:0100561)1.75698861
118Reduced subcutaneous adipose tissue (HP:0003758)1.75539651
119Joint stiffness (HP:0001387)1.75264872
120Abnormal delivery (HP:0001787)1.74340101
121Onycholysis (HP:0001806)1.73927634
122Axonal loss (HP:0003447)1.73272461
123Muscle fiber splitting (HP:0003555)1.73188837
124Bifid scrotum (HP:0000048)1.72184182
125Camptodactyly of toe (HP:0001836)1.72116233
126Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71954352
127Arterial tortuosity (HP:0005116)1.71469219
128Acanthosis nigricans (HP:0000956)1.70512930
129Vertebral compression fractures (HP:0002953)1.68980668
130Alacrima (HP:0000522)1.68757613
131Right ventricular cardiomyopathy (HP:0011663)1.68108864
132Ankyloglossia (HP:0010296)1.67968418
133Bronchomalacia (HP:0002780)1.67455727
134Elfin facies (HP:0004428)1.66878037
135Bowel diverticulosis (HP:0005222)1.65734103
136Hypoplastic ischia (HP:0003175)1.65671586
137Broad toe (HP:0001837)1.64535793
138Nonimmune hydrops fetalis (HP:0001790)1.64470969
139Abnormality of the distal phalanges of the toes (HP:0010182)1.64330586
140Arnold-Chiari malformation (HP:0002308)1.64149156
141Macroorchidism (HP:0000053)1.64109089
142Onion bulb formation (HP:0003383)1.64094546
143Epidermoid cyst (HP:0200040)1.63480085
144Systemic lupus erythematosus (HP:0002725)1.63370980
145Hematochezia (HP:0002573)1.63029456
146Abnormality of the intrinsic pathway (HP:0010989)1.62748625
147Humeroradial synostosis (HP:0003041)1.62131508
148Synostosis involving the elbow (HP:0003938)1.62131508
149Hemorrhage of the eye (HP:0011885)1.60296376
150Long toe (HP:0010511)1.59975080
151Selective tooth agenesis (HP:0001592)1.58912538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.49003002
2TRIB33.45417797
3LATS13.18815807
4SIK13.07587129
5EPHA22.96707668
6STK392.71726551
7FGFR22.67903547
8ERN12.51040631
9MET2.50040381
10LATS22.33850649
11TTN2.26462200
12SMG12.05961607
13PDGFRA2.04413638
14DDR22.00718434
15TAOK21.70658214
16DMPK1.69006786
17RIPK11.67772281
18CDK121.66805966
19EPHA31.60380100
20BCKDK1.57560978
21FGFR41.56722840
22IRAK31.56363846
23PTK61.54275854
24OXSR11.50616995
25PIK3CA1.49926035
26PDGFRB1.49503584
27CAMK1D1.42438721
28TRPM71.41205748
29MYLK1.39344516
30PKN11.38414860
31NUAK11.35908911
32INSRR1.30449192
33KDR1.28131893
34BMX1.26023786
35PAK21.24239822
36TESK11.23482894
37MAP3K61.21110271
38FRK1.19256280
39PKN21.18387830
40PRKD21.17971768
41CSNK1A1L1.12336525
42TBK11.12132887
43NEK91.11720617
44ROCK21.11448679
45CAMK1G1.09484409
46LRRK21.07822455
47RPS6KA21.03939998
48AKT31.02957017
49STK31.02712663
50MAPKAPK31.02094919
51MAPKAPK50.98221220
52ILK0.95006382
53JAK30.91362548
54PRKD10.91092365
55TGFBR20.90829330
56IKBKE0.90593552
57STK380.90387425
58MST1R0.90184557
59TIE10.89397935
60MAP3K20.88228182
61PTK20.87209304
62JAK10.86890412
63EPHB20.86397928
64PBK0.85223222
65MAP3K70.83315230
66ERBB40.81992478
67LMTK20.80412313
68GSK3A0.79465764
69ARAF0.76854276
70ROCK10.76242967
71FER0.75782083
72WNK10.75204732
73FGFR30.75084836
74KSR20.74591683
75PRKG20.73126642
76FLT30.72270815
77CSNK1G10.72209007
78FGFR10.69735096
79PRPF4B0.69631250
80ABL20.69557821
81MAPK70.69027613
82PRKCH0.67297432
83CDK60.64453109
84MOS0.64222165
85MAP3K30.64057428
86MAP3K140.63501431
87WNK40.63397016
88MELK0.63321154
89TYK20.62587651
90PAK30.61942863
91MTOR0.60282053
92EEF2K0.59300291
93CSNK1G30.58937935
94PIM20.58533773
95PTK2B0.57994563
96PAK40.57335959
97BCR0.57275349
98KIT0.56879549
99RET0.56702742
100CSF1R0.55779161
101NEK60.54879827
102NTRK10.54873312
103LIMK10.54816881
104MAP3K10.52795171
105TYRO30.52095229
106INSR0.52078626
107CAMK2G0.51692006
108PHKG20.51650335
109PHKG10.51650335
110IRAK10.51130346
111PDPK10.50123286
112NME20.49923671
113RPS6KC10.49142760
114RPS6KL10.49142760
115SGK2230.48520883
116SGK4940.48520883
117CLK10.47996132
118PIK3CG0.47596176
119MARK20.47520748
120MAP3K80.47405855
121MAP3K130.46682568
122PRKAA20.46376264
123FYN0.45098250
124CSK0.44837301
125PRKCQ0.44691842
126MAP2K10.44156307
127MAPK120.43980625
128ERBB20.43649448
129CDC42BPA0.43371868
130CAMK2D0.42542205
131ICK0.42285181
132MAP2K60.40037451
133MAP2K30.39797982
134TGFBR10.37882180
135MAP3K100.37437654
136HIPK20.36834311
137CDK90.34061247
138PRKD30.33453852
139STK240.31575692
140MAPK110.30515066
141RPS6KB20.28668293
142SRC0.28058379
143MAPKAPK20.27909840
144RPS6KA60.27849030
145ZAP700.26632426

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.57975039
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.84482717
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.56932009
4Fatty acid elongation_Homo sapiens_hsa000622.41528985
5Steroid biosynthesis_Homo sapiens_hsa001002.19191210
6Sulfur metabolism_Homo sapiens_hsa009202.11712188
7Complement and coagulation cascades_Homo sapiens_hsa046102.04744544
8Other glycan degradation_Homo sapiens_hsa005112.04585909
9ECM-receptor interaction_Homo sapiens_hsa045122.03634543
10Fatty acid metabolism_Homo sapiens_hsa012122.01744690
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.96516261
12Fatty acid degradation_Homo sapiens_hsa000711.94139465
13PPAR signaling pathway_Homo sapiens_hsa033201.83422285
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82042062
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77787399
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73625073
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71505762
18Propanoate metabolism_Homo sapiens_hsa006401.71153241
19Histidine metabolism_Homo sapiens_hsa003401.69660427
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64928540
21Chemical carcinogenesis_Homo sapiens_hsa052041.55049869
22Bladder cancer_Homo sapiens_hsa052191.53267692
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.51865441
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51256019
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46734183
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.40076923
27Malaria_Homo sapiens_hsa051441.38628169
28Focal adhesion_Homo sapiens_hsa045101.37693205
29Tryptophan metabolism_Homo sapiens_hsa003801.37266670
30Staphylococcus aureus infection_Homo sapiens_hsa051501.36078201
31Peroxisome_Homo sapiens_hsa041461.33691851
32Caffeine metabolism_Homo sapiens_hsa002321.32382304
33Fatty acid biosynthesis_Homo sapiens_hsa000611.28287695
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.26580454
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24430559
36Arginine biosynthesis_Homo sapiens_hsa002201.22284802
37Galactose metabolism_Homo sapiens_hsa000521.20388933
38Bile secretion_Homo sapiens_hsa049761.18069228
39Thyroid cancer_Homo sapiens_hsa052161.16280759
40Butanoate metabolism_Homo sapiens_hsa006501.13252009
41Fructose and mannose metabolism_Homo sapiens_hsa000511.10024987
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03489531
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02138261
44Glycerolipid metabolism_Homo sapiens_hsa005611.02001367
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01622219
46Protein digestion and absorption_Homo sapiens_hsa049741.00086826
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98046719
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97097422
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96495727
50Insulin signaling pathway_Homo sapiens_hsa049100.96447125
51beta-Alanine metabolism_Homo sapiens_hsa004100.96213866
52Selenocompound metabolism_Homo sapiens_hsa004500.96170982
53Amoebiasis_Homo sapiens_hsa051460.93803307
54Arginine and proline metabolism_Homo sapiens_hsa003300.91786358
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91494125
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90986686
57Endometrial cancer_Homo sapiens_hsa052130.90652352
58VEGF signaling pathway_Homo sapiens_hsa043700.89911217
59Small cell lung cancer_Homo sapiens_hsa052220.88742082
60Acute myeloid leukemia_Homo sapiens_hsa052210.88542078
61Proteoglycans in cancer_Homo sapiens_hsa052050.88030009
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.87265076
63AMPK signaling pathway_Homo sapiens_hsa041520.86861752
64ABC transporters_Homo sapiens_hsa020100.86652311
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86564887
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.85290940
67Retinol metabolism_Homo sapiens_hsa008300.85065336
68Vitamin digestion and absorption_Homo sapiens_hsa049770.84290647
69Fat digestion and absorption_Homo sapiens_hsa049750.84173936
70Vitamin B6 metabolism_Homo sapiens_hsa007500.82617321
71Glioma_Homo sapiens_hsa052140.82468496
72GnRH signaling pathway_Homo sapiens_hsa049120.82065286
73Sphingolipid metabolism_Homo sapiens_hsa006000.80101339
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79264205
75Renin-angiotensin system_Homo sapiens_hsa046140.79183785
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78717039
77Tyrosine metabolism_Homo sapiens_hsa003500.78337509
78Linoleic acid metabolism_Homo sapiens_hsa005910.76438563
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74543858
80Prostate cancer_Homo sapiens_hsa052150.74244034
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.73798694
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73388167
83ErbB signaling pathway_Homo sapiens_hsa040120.72215747
84Basal cell carcinoma_Homo sapiens_hsa052170.71587257
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71038243
86Ether lipid metabolism_Homo sapiens_hsa005650.70251224
87Rap1 signaling pathway_Homo sapiens_hsa040150.70118510
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69054892
89Glutathione metabolism_Homo sapiens_hsa004800.68178978
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67889926
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67655532
92Estrogen signaling pathway_Homo sapiens_hsa049150.67476296
93mTOR signaling pathway_Homo sapiens_hsa041500.67160875
94Lysine degradation_Homo sapiens_hsa003100.67130319
95Melanogenesis_Homo sapiens_hsa049160.66858337
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.65805483
97Pentose phosphate pathway_Homo sapiens_hsa000300.65602212
98Melanoma_Homo sapiens_hsa052180.65354227
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65151685
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65054908
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64710754
102Non-small cell lung cancer_Homo sapiens_hsa052230.64179045
103TGF-beta signaling pathway_Homo sapiens_hsa043500.63803469
104Insulin resistance_Homo sapiens_hsa049310.63730552
105Axon guidance_Homo sapiens_hsa043600.63676686
106Lysosome_Homo sapiens_hsa041420.63560317
107Pertussis_Homo sapiens_hsa051330.62497809
108Choline metabolism in cancer_Homo sapiens_hsa052310.61324751
109HIF-1 signaling pathway_Homo sapiens_hsa040660.60106796
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59757996
111Adherens junction_Homo sapiens_hsa045200.59257661
112Phenylalanine metabolism_Homo sapiens_hsa003600.58441180
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58210129
114Hepatitis C_Homo sapiens_hsa051600.57365053
115Dilated cardiomyopathy_Homo sapiens_hsa054140.56733324
116Toxoplasmosis_Homo sapiens_hsa051450.55421109
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54901235
118Endocytosis_Homo sapiens_hsa041440.54212476
119TNF signaling pathway_Homo sapiens_hsa046680.53903901
120Biosynthesis of amino acids_Homo sapiens_hsa012300.53412611
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53295650
122Sulfur relay system_Homo sapiens_hsa041220.52901657
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51263504
124Gap junction_Homo sapiens_hsa045400.50667708
125Ovarian steroidogenesis_Homo sapiens_hsa049130.50455945
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50204589
127Glucagon signaling pathway_Homo sapiens_hsa049220.50185782
128Hippo signaling pathway_Homo sapiens_hsa043900.50118742
129Starch and sucrose metabolism_Homo sapiens_hsa005000.49346439
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47264766
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46559979
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45905617
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44562411
134Tight junction_Homo sapiens_hsa045300.44372555
135Notch signaling pathway_Homo sapiens_hsa043300.44157553
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44132757
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42721323
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.42559510
139Viral myocarditis_Homo sapiens_hsa054160.40181542
140Pancreatic cancer_Homo sapiens_hsa052120.39437471
141Pathways in cancer_Homo sapiens_hsa052000.38745723
142MicroRNAs in cancer_Homo sapiens_hsa052060.38167796
143Renal cell carcinoma_Homo sapiens_hsa052110.37732020
144Chronic myeloid leukemia_Homo sapiens_hsa052200.37703778
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.37431998
146Prion diseases_Homo sapiens_hsa050200.37244793
147Platelet activation_Homo sapiens_hsa046110.36797786
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.33058037
149Hedgehog signaling pathway_Homo sapiens_hsa043400.32168471

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