SNX16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.47707796
2regulation of meiosis I (GO:0060631)4.88700986
3neuron cell-cell adhesion (GO:0007158)4.71764909
4synapsis (GO:0007129)4.54666172
5synaptic vesicle exocytosis (GO:0016079)4.53389356
6positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.40548932
7inositol phosphate dephosphorylation (GO:0046855)4.26807475
8phosphorylated carbohydrate dephosphorylation (GO:0046838)4.26807475
9inositol phosphate catabolic process (GO:0071545)4.25960709
10vocalization behavior (GO:0071625)4.21905318
11protein localization to synapse (GO:0035418)4.20871487
12water-soluble vitamin biosynthetic process (GO:0042364)4.19425175
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.12341796
14DNA methylation involved in gamete generation (GO:0043046)4.11376494
15regulation of DNA endoreduplication (GO:0032875)4.08572874
16mitotic sister chromatid cohesion (GO:0007064)4.05324516
17positive regulation of action potential (GO:0045760)4.04942754
18protein targeting to Golgi (GO:0000042)3.98734321
19neuronal action potential propagation (GO:0019227)3.98259344
20establishment of protein localization to Golgi (GO:0072600)3.94189393
21retrograde transport, vesicle recycling within Golgi (GO:0000301)3.87296870
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.83357334
23regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.81695285
24polyol catabolic process (GO:0046174)3.78827773
25tachykinin receptor signaling pathway (GO:0007217)3.76417203
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.73386154
27positive regulation of synapse maturation (GO:0090129)3.69536923
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.68312151
29chaperone-mediated protein transport (GO:0072321)3.67161607
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.53778921
31regulation of synaptic vesicle exocytosis (GO:2000300)3.53396196
32glutamate receptor signaling pathway (GO:0007215)3.51714582
33dopamine transport (GO:0015872)3.49093107
34glutamate secretion (GO:0014047)3.48151909
35neuron recognition (GO:0008038)3.47824244
36response to nitrosative stress (GO:0051409)3.47157498
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43777834
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43584437
39relaxation of smooth muscle (GO:0044557)3.41858819
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.41662532
41positive regulation of vasculogenesis (GO:2001214)3.40035795
42magnesium ion transport (GO:0015693)3.38822553
43regulation of glutamate receptor signaling pathway (GO:1900449)3.38014625
44regulation of hexokinase activity (GO:1903299)3.32077849
45regulation of glucokinase activity (GO:0033131)3.32077849
46regulation of synaptic vesicle transport (GO:1902803)3.29730682
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.27934001
48Golgi to endosome transport (GO:0006895)3.25909171
49male meiosis (GO:0007140)3.25697846
50negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25459848
51gene silencing by RNA (GO:0031047)3.25275395
52neural tube formation (GO:0001841)3.20757672
53neuron-neuron synaptic transmission (GO:0007270)3.20233411
54sister chromatid cohesion (GO:0007062)3.19142252
55behavioral defense response (GO:0002209)3.17489609
56behavioral fear response (GO:0001662)3.17489609
57protein localization to Golgi apparatus (GO:0034067)3.15572434
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.12016784
59proteasome assembly (GO:0043248)3.11788328
60regulation of synapse maturation (GO:0090128)3.11333986
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10961257
62ATP synthesis coupled proton transport (GO:0015986)3.10617334
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10617334
64neurotransmitter secretion (GO:0007269)3.09792192
65acrosome assembly (GO:0001675)3.08683339
66regulation of Golgi to plasma membrane protein transport (GO:0042996)3.08021817
67synaptic vesicle endocytosis (GO:0048488)3.07757401
68synaptic transmission, glutamatergic (GO:0035249)3.07583043
69long-term memory (GO:0007616)3.06352458
70regulation of clathrin-mediated endocytosis (GO:2000369)3.05132668
71regulation of long-term neuronal synaptic plasticity (GO:0048169)3.04604467
72prostate gland growth (GO:0060736)3.03369124
73peptidyl-cysteine modification (GO:0018198)3.03212509
74positive regulation of protein autophosphorylation (GO:0031954)3.03004679
75rRNA methylation (GO:0031167)3.01879566
76male meiosis I (GO:0007141)3.01124600
77axonal fasciculation (GO:0007413)3.00847512
78xenobiotic catabolic process (GO:0042178)3.00185693
79negative regulation of interleukin-17 production (GO:0032700)2.99343405
80fear response (GO:0042596)2.99109278
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98349558
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98349558
83positive regulation of mitotic sister chromatid separation (GO:1901970)2.98349558
84regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.97048343
85intra-S DNA damage checkpoint (GO:0031573)2.96366356
86nerve growth factor signaling pathway (GO:0038180)2.95828838
87positive regulation of cAMP-mediated signaling (GO:0043950)2.94567456
88synaptic vesicle maturation (GO:0016188)2.93058426
89cell migration in hindbrain (GO:0021535)2.92022694
90negative regulation of dendrite morphogenesis (GO:0050774)2.90126805
91ribonucleoprotein complex disassembly (GO:0032988)2.88431045
92positive regulation of synapse assembly (GO:0051965)2.88337452
93positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.87797479
94postsynaptic membrane organization (GO:0001941)2.87398952
95negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84826153
96DNA double-strand break processing (GO:0000729)2.84790730
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.82797500
98negative regulation of JUN kinase activity (GO:0043508)2.82365143
99smooth muscle tissue development (GO:0048745)2.81813702
100synaptic vesicle transport (GO:0048489)2.81273662
101establishment of synaptic vesicle localization (GO:0097480)2.81273662
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.80576365
103negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.80163377
104response to histamine (GO:0034776)2.79409037
105exploration behavior (GO:0035640)2.78501988
106guanosine-containing compound biosynthetic process (GO:1901070)2.77083620
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.76801470
108termination of RNA polymerase III transcription (GO:0006386)2.76801470
109regulation of neuronal synaptic plasticity (GO:0048168)2.76416959
110transmission of nerve impulse (GO:0019226)2.74318939
111neurotransmitter catabolic process (GO:0042135)2.73500498
112transferrin transport (GO:0033572)2.73086932
113negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.72752608
1147-methylguanosine mRNA capping (GO:0006370)2.71503004
115regulation of platelet aggregation (GO:0090330)2.71178556
116neurotransmitter transport (GO:0006836)2.71042739
117phosphatidylinositol dephosphorylation (GO:0046856)2.70449122
118startle response (GO:0001964)2.70342456
119organelle disassembly (GO:1903008)2.70261961
120positive regulation of interferon-beta production (GO:0032728)2.70165270
121establishment of vesicle localization (GO:0051650)2.70002662
122regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.69439429
123regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.69439429
124regulation of type B pancreatic cell apoptotic process (GO:2000674)2.69307673
125meiotic cell cycle (GO:0051321)2.68878183
126negative regulation of microtubule polymerization (GO:0031115)2.68626101
127regulation of glutamate secretion (GO:0014048)2.68087551
128positive regulation of macroautophagy (GO:0016239)2.66269887
129proline transport (GO:0015824)2.65722207
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65566893
131positive regulation of mitochondrial fission (GO:0090141)2.65249387
132growth hormone receptor signaling pathway (GO:0060396)2.65021456
133presynaptic membrane assembly (GO:0097105)2.64944373
134definitive hemopoiesis (GO:0060216)2.64870180
135mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.64344811
136positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.64344811
137negative regulation of signal transduction by p53 class mediator (GO:1901797)2.64231882
138RNA capping (GO:0036260)2.64148626
1397-methylguanosine RNA capping (GO:0009452)2.64148626
140regulation of memory T cell differentiation (GO:0043380)2.63505137
141energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.63228136
142ATP hydrolysis coupled proton transport (GO:0015991)2.63228136
143rRNA modification (GO:0000154)2.62829458
144mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62628638
145layer formation in cerebral cortex (GO:0021819)2.62560360
146neurotransmitter-gated ion channel clustering (GO:0072578)2.61858534
147dendrite development (GO:0016358)2.61498773
148regulation of vesicle fusion (GO:0031338)2.61312086
149positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60978495
150cell wall macromolecule catabolic process (GO:0016998)2.60754447
151chromosome organization involved in meiosis (GO:0070192)2.60750605
152establishment of melanosome localization (GO:0032401)2.59766376
153monoubiquitinated protein deubiquitination (GO:0035520)2.59673162
154regulation of interferon-beta biosynthetic process (GO:0045357)2.58801301
155regulation of interleukin-17 production (GO:0032660)2.58572266
156regulation of excitatory postsynaptic membrane potential (GO:0060079)2.58116003
157keratinocyte development (GO:0003334)2.58036994
158cullin deneddylation (GO:0010388)2.57865487
159regulation of postsynaptic membrane potential (GO:0060078)2.56534680
160intraspecies interaction between organisms (GO:0051703)2.56207067
161social behavior (GO:0035176)2.56207067
162behavioral response to cocaine (GO:0048148)2.55071083
163nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.54812752
164reciprocal meiotic recombination (GO:0007131)2.54658117
165reciprocal DNA recombination (GO:0035825)2.54658117
166presynaptic membrane organization (GO:0097090)2.54348588
167regulation of interferon-alpha production (GO:0032647)2.54039882
168phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.54033780
169dendritic spine morphogenesis (GO:0060997)2.53609780
170protein neddylation (GO:0045116)2.53329713
171establishment of protein localization to mitochondrion (GO:0072655)2.53043447
172neuromuscular process controlling posture (GO:0050884)2.53030589
173protein deneddylation (GO:0000338)2.52996862
174positive regulation of natural killer cell activation (GO:0032816)2.52535442
175negative regulation of meiotic cell cycle (GO:0051447)2.52523161
176female gonad development (GO:0008585)2.52460607
177regulation of neurotransmitter levels (GO:0001505)2.51920530
178protein targeting to mitochondrion (GO:0006626)2.51687360
179regulation of dendritic spine morphogenesis (GO:0061001)2.51638382
180cerebellar granule cell differentiation (GO:0021707)2.51415564
181regulation of neurotransmitter secretion (GO:0046928)2.51266413
182genitalia morphogenesis (GO:0035112)2.50990248
183interleukin-6-mediated signaling pathway (GO:0070102)2.50004423
184serotonin receptor signaling pathway (GO:0007210)2.49630811
185synapse assembly (GO:0007416)2.49295846
186positive regulation of response to extracellular stimulus (GO:0032106)2.47826167
187positive regulation of response to nutrient levels (GO:0032109)2.47826167
188glycerophospholipid catabolic process (GO:0046475)2.47330577
189peptidyl-threonine dephosphorylation (GO:0035970)2.46230517
190protein K11-linked deubiquitination (GO:0035871)2.45812011
191ether lipid metabolic process (GO:0046485)2.45487733
192thrombin receptor signaling pathway (GO:0070493)2.45094036
193adaptation of signaling pathway (GO:0023058)2.44605394
194positive regulation of synaptic transmission, GABAergic (GO:0032230)2.44338427
195positive regulation of cell cycle G1/S phase transition (GO:1902808)2.44222801
196cellular response to dsRNA (GO:0071359)2.43704918
197zinc ion transport (GO:0006829)2.42286726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.98861234
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.06178928
3GBX2_23144817_ChIP-Seq_PC3_Human3.21888657
4TAF15_26573619_Chip-Seq_HEK293_Human2.73305783
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.62487077
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58708211
7REST_21632747_ChIP-Seq_MESCs_Mouse2.43625187
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33126099
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27986738
10* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24040779
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21288875
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18476113
13* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17099500
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07924517
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05586681
16* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05582696
17FUS_26573619_Chip-Seq_HEK293_Human2.02646164
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.02195476
19* ELK1_19687146_ChIP-ChIP_HELA_Human1.93666867
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93041068
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88507000
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.87189253
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84428742
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.84327013
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82702655
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82115863
27ZNF274_21170338_ChIP-Seq_K562_Hela1.76963466
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76842945
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72065096
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.71582545
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.70343274
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.70343274
33P300_19829295_ChIP-Seq_ESCs_Human1.67076023
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67056307
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66759026
36* VDR_22108803_ChIP-Seq_LS180_Human1.66595404
37* RNF2_27304074_Chip-Seq_NSC_Mouse1.64175952
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63409650
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62195847
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62195847
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.60539473
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60299277
43* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60096766
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.59605210
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59578895
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59316645
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57322624
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.56706405
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54982669
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53195872
51* ETS1_20019798_ChIP-Seq_JURKAT_Human1.52944604
52* EWS_26573619_Chip-Seq_HEK293_Human1.50615300
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50023407
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49545857
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48936178
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.48668987
57SMAD4_21799915_ChIP-Seq_A2780_Human1.48457629
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46611809
59* CDX2_22108803_ChIP-Seq_LS180_Human1.44051762
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44025415
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.43874882
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.42415737
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.40807797
64* CBX2_27304074_Chip-Seq_ESCs_Mouse1.40026619
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37299239
66VDR_23849224_ChIP-Seq_CD4+_Human1.33925485
67AR_21572438_ChIP-Seq_LNCaP_Human1.33256436
68CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.33073910
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32952874
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32848025
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32760043
72* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31993836
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31941022
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31930313
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.31826937
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30159349
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30147301
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.29342271
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28494364
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28156062
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.27294722
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26567450
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26366711
84* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26132795
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24976913
86JUN_21703547_ChIP-Seq_K562_Human1.24561644
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.24530107
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23863422
89P53_22387025_ChIP-Seq_ESCs_Mouse1.23006688
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21845677
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21562954
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.20851061
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20543914
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20358980
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.19321549
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18191069
97CBP_20019798_ChIP-Seq_JUKART_Human1.18191069
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18054857
99* CMYC_18555785_Chip-Seq_ESCs_Mouse1.17751915
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.17213798
101* BCAT_22108803_ChIP-Seq_LS180_Human1.16470174
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16440474
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15376396
104NANOG_19829295_ChIP-Seq_ESCs_Human1.15276861
105SOX2_19829295_ChIP-Seq_ESCs_Human1.15276861
106* ER_23166858_ChIP-Seq_MCF-7_Human1.15046436
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14987974
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14082080
109* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13460519
110GATA1_22025678_ChIP-Seq_K562_Human1.13098390
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.12964052
112AR_25329375_ChIP-Seq_VCAP_Human1.12548189
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11251305
114TCF4_22108803_ChIP-Seq_LS180_Human1.11163127
115P300_18555785_Chip-Seq_ESCs_Mouse1.10366557
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09299318
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.09189028
118IRF8_21731497_ChIP-ChIP_J774_Mouse1.08629813
119SALL4_22934838_ChIP-ChIP_CD34+_Human1.07712716
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07416570
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07212322
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07179967
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06659770
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06453963
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05880994
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05417822
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04414993
128POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04163590
129HTT_18923047_ChIP-ChIP_STHdh_Human1.04102129
130* TCF4_23295773_ChIP-Seq_U87_Human1.03335959
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03027080
132YY1_21170310_ChIP-Seq_MESCs_Mouse1.02807207
133OCT4_18555785_Chip-Seq_ESCs_Mouse1.02752515
134* STAT3_23295773_ChIP-Seq_U87_Human1.02295792
135* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01512863
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01413866
137KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00661450
138IRF1_19129219_ChIP-ChIP_H3396_Human1.00329666
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00311599
140STAT3_18555785_Chip-Seq_ESCs_Mouse1.00251017
141BRD4_25478319_ChIP-Seq_HGPS_Human0.99189645
142RUNX2_22187159_ChIP-Seq_PCA_Human0.99070858
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98673900
144* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97565558
145* IGF1R_20145208_ChIP-Seq_DFB_Human0.96910749
146* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95447760
147* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94959240
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.94830114
149* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94504107
150* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94176146
151ZNF263_19887448_ChIP-Seq_K562_Human0.93045102
152* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92159590
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91968953
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90462617
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90462617
156* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89538536
157MYC_18555785_ChIP-Seq_MESCs_Mouse0.88896339
158* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86322255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.16131951
2MP0004859_abnormal_synaptic_plasticity4.22040211
3MP0009697_abnormal_copulation4.18398832
4MP0002138_abnormal_hepatobiliary_system3.65419266
5MP0003635_abnormal_synaptic_transmissio3.26092328
6MP0002735_abnormal_chemical_nociception3.16080811
7MP0004270_analgesia3.05372473
8MP0001968_abnormal_touch/_nociception3.01149785
9MP0003195_calcinosis2.85927609
10MP0009046_muscle_twitch2.85888197
11MP0006276_abnormal_autonomic_nervous2.80374728
12MP0002734_abnormal_mechanical_nocicepti2.77223935
13MP0002063_abnormal_learning/memory/cond2.73524700
14MP0009745_abnormal_behavioral_response2.69129250
15MP0010234_abnormal_vibrissa_follicle2.56887439
16MP0001529_abnormal_vocalization2.52953425
17MP0004147_increased_porphyrin_level2.50855051
18MP0002736_abnormal_nociception_after2.50357851
19MP0002064_seizures2.49525962
20MP0010678_abnormal_skin_adnexa2.48227272
21MP0002572_abnormal_emotion/affect_behav2.45843653
22MP0002272_abnormal_nervous_system2.42110791
23MP0009780_abnormal_chondrocyte_physiolo2.32239648
24MP0005423_abnormal_somatic_nervous2.29515697
25MP0001440_abnormal_grooming_behavior2.29320839
26MP0001501_abnormal_sleep_pattern2.17635122
27MP0002184_abnormal_innervation2.13573501
28MP0000383_abnormal_hair_follicle2.13016406
29MP0004084_abnormal_cardiac_muscle2.10160750
30MP0001486_abnormal_startle_reflex2.10058127
31MP0000427_abnormal_hair_cycle2.07381936
32MP0000778_abnormal_nervous_system2.03480802
33MP0003656_abnormal_erythrocyte_physiolo2.02663310
34MP0002733_abnormal_thermal_nociception2.02113898
35MP0001970_abnormal_pain_threshold2.00544897
36MP0001188_hyperpigmentation2.00140677
37MP0003890_abnormal_embryonic-extraembry1.99016283
38MP0010352_gastrointestinal_tract_polyps1.96970758
39MP0001984_abnormal_olfaction1.95531308
40MP0001905_abnormal_dopamine_level1.94452078
41MP0002067_abnormal_sensory_capabilities1.87045690
42MP0003718_maternal_effect1.82776359
43MP0002009_preneoplasia1.82260674
44MP0004808_abnormal_hematopoietic_stem1.81796563
45MP0008260_abnormal_autophagy1.81501022
46MP0003123_paternal_imprinting1.70432182
47MP0003879_abnormal_hair_cell1.67939676
48MP0002332_abnormal_exercise_endurance1.66110278
49MP0002254_reproductive_system_inflammat1.64296057
50MP0005410_abnormal_fertilization1.62253367
51MP0002557_abnormal_social/conspecific_i1.58793344
52MP0004924_abnormal_behavior1.57544054
53MP0005386_behavior/neurological_phenoty1.57544054
54MP0000569_abnormal_digit_pigmentation1.54168173
55MP0003329_amyloid_beta_deposits1.53348418
56MP0002148_abnormal_hypersensitivity_rea1.52871502
57MP0001919_abnormal_reproductive_system1.50325529
58MP0003943_abnormal_hepatobiliary_system1.46180688
59MP0003315_abnormal_perineum_morphology1.43711841
60MP0005645_abnormal_hypothalamus_physiol1.43656647
61MP0005464_abnormal_platelet_physiology1.41852108
62MP0002822_catalepsy1.37901262
63MP0004142_abnormal_muscle_tone1.36942984
64MP0005075_abnormal_melanosome_morpholog1.35890851
65MP0001764_abnormal_homeostasis1.35634507
66MP0005647_abnormal_sex_gland1.35499701
67MP0003303_peritoneal_inflammation1.31652131
68MP0000955_abnormal_spinal_cord1.31306844
69MP0004811_abnormal_neuron_physiology1.30387696
70MP0002882_abnormal_neuron_morphology1.27485417
71MP0008877_abnormal_DNA_methylation1.25373802
72MP0010368_abnormal_lymphatic_system1.24675648
73MP0002066_abnormal_motor_capabilities/c1.24263853
74MP0002102_abnormal_ear_morphology1.23407521
75MP0002638_abnormal_pupillary_reflex1.22720933
76MP0006054_spinal_hemorrhage1.21273179
77MP0003950_abnormal_plasma_membrane1.20866569
78MP0010386_abnormal_urinary_bladder1.17793281
79MP0003122_maternal_imprinting1.14462759
80MP0006292_abnormal_olfactory_placode1.14257404
81MP0006072_abnormal_retinal_apoptosis1.14170484
82MP0005499_abnormal_olfactory_system1.12875689
83MP0005394_taste/olfaction_phenotype1.12875689
84MP0005646_abnormal_pituitary_gland1.12304595
85MP0003252_abnormal_bile_duct1.11467451
86MP0003186_abnormal_redox_activity1.11312433
87MP0002837_dystrophic_cardiac_calcinosis1.09583551
88MP0002006_tumorigenesis1.08667049
89MP0002693_abnormal_pancreas_physiology1.07366843
90MP0001145_abnormal_male_reproductive1.05824863
91MP0004036_abnormal_muscle_relaxation1.05201572
92MP0005551_abnormal_eye_electrophysiolog1.04820076
93MP0008569_lethality_at_weaning1.04735815
94MP0002752_abnormal_somatic_nervous1.02379942
95MP0005220_abnormal_exocrine_pancreas1.01218291
96MP0002909_abnormal_adrenal_gland1.00218535
97MP0004145_abnormal_muscle_electrophysio0.99481084
98MP0001502_abnormal_circadian_rhythm0.99292341
99MP0002152_abnormal_brain_morphology0.97845823
100MP0002876_abnormal_thyroid_physiology0.97533329
101MP0008789_abnormal_olfactory_epithelium0.97497514
102MP0008004_abnormal_stomach_pH0.97339530
103MP0002163_abnormal_gland_morphology0.97182294
104MP0004742_abnormal_vestibular_system0.96263068
105MP0005084_abnormal_gallbladder_morpholo0.96222812
106MP0001963_abnormal_hearing_physiology0.95467704
107MP0005187_abnormal_penis_morphology0.94447415
108MP0003121_genomic_imprinting0.92618277
109MP0009764_decreased_sensitivity_to0.91892192
110MP0001485_abnormal_pinna_reflex0.90543689
111MP0002751_abnormal_autonomic_nervous0.88009712
112MP0003787_abnormal_imprinting0.87959639
113MP0002160_abnormal_reproductive_system0.87778330
114MP0000631_abnormal_neuroendocrine_gland0.87767438
115MP0010307_abnormal_tumor_latency0.86972726
116MP0005535_abnormal_body_temperature0.86084427
117MP0002277_abnormal_respiratory_mucosa0.85124070
118MP0003693_abnormal_embryo_hatching0.85074749
119MP0003938_abnormal_ear_development0.84682566
120MP0004484_altered_response_of0.84483667
121MP0009379_abnormal_foot_pigmentation0.83804822
122MP0002229_neurodegeneration0.83345698
123MP0001986_abnormal_taste_sensitivity0.82874727
124MP0001191_abnormal_skin_condition0.82837065
125MP0001879_abnormal_lymphatic_vessel0.78962465
126MP0005253_abnormal_eye_physiology0.78860312
127MP0003136_yellow_coat_color0.78471304
128MP0000026_abnormal_inner_ear0.78357821
129MP0004215_abnormal_myocardial_fiber0.77288809
130MP0005595_abnormal_vascular_smooth0.75505988
131MP0004858_abnormal_nervous_system0.74838651
132MP0006035_abnormal_mitochondrial_morpho0.74475210
133MP0005379_endocrine/exocrine_gland_phen0.72740889
134MP0001119_abnormal_female_reproductive0.72576237
135MP0003861_abnormal_nervous_system0.71810663
136MP0002166_altered_tumor_susceptibility0.70896088
137MP0002069_abnormal_eating/drinking_beha0.70691353
138MP0003786_premature_aging0.69813194
139MP0004885_abnormal_endolymph0.69619374
140MP0001944_abnormal_pancreas_morphology0.68782718
141MP0008007_abnormal_cellular_replicative0.68473471
142MP0004264_abnormal_extraembryonic_tissu0.67897704
143MP0005397_hematopoietic_system_phenotyp0.67381482
144MP0001545_abnormal_hematopoietic_system0.67381482
145MP0001835_abnormal_antigen_presentation0.67332734
146MP0008875_abnormal_xenobiotic_pharmacok0.66790197
147MP0000015_abnormal_ear_pigmentation0.64190290
148MP0005389_reproductive_system_phenotype0.64159380
149MP0004085_abnormal_heartbeat0.62900090
150MP0008057_abnormal_DNA_replication0.62845124
151MP0003698_abnormal_male_reproductive0.62839675
152MP0005174_abnormal_tail_pigmentation0.62571084
153MP0001929_abnormal_gametogenesis0.60795540
154MP0003634_abnormal_glial_cell0.60601494
155MP0002210_abnormal_sex_determination0.60429092
156MP0005332_abnormal_amino_acid0.60044121
157MP0009765_abnormal_xenobiotic_induced0.59991198
158MP0006082_CNS_inflammation0.58839052
159MP0004957_abnormal_blastocyst_morpholog0.58085382
160MP0000653_abnormal_sex_gland0.57192843
161MP0008995_early_reproductive_senescence0.57164656
162MP0008058_abnormal_DNA_repair0.57133385
163MP0000465_gastrointestinal_hemorrhage0.55489574
164MP0000230_abnormal_systemic_arterial0.55271058
165MP0000604_amyloidosis0.55270384
166MP0003699_abnormal_female_reproductive0.55150174
167MP0003724_increased_susceptibility_to0.54815981
168MP0003191_abnormal_cellular_cholesterol0.52631467
169MP0001216_abnormal_epidermal_layer0.52537710

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.07242800
2Myokymia (HP:0002411)4.63483263
3Visual hallucinations (HP:0002367)4.37712868
4Atonic seizures (HP:0010819)4.11448388
5Focal seizures (HP:0007359)4.07877896
6Papillary thyroid carcinoma (HP:0002895)3.90811091
7Thyroid carcinoma (HP:0002890)3.83656533
8Absence seizures (HP:0002121)3.82673175
9Epileptic encephalopathy (HP:0200134)3.47264925
10Dialeptic seizures (HP:0011146)3.45950274
11Abolished electroretinogram (ERG) (HP:0000550)3.41374453
12Delusions (HP:0000746)3.33753517
13Abnormality of the labia minora (HP:0012880)3.33561001
14Febrile seizures (HP:0002373)3.31739217
15Conjunctival hamartoma (HP:0100780)3.23264453
16Volvulus (HP:0002580)3.22702075
17Central scotoma (HP:0000603)3.22359260
18Progressive cerebellar ataxia (HP:0002073)3.18841939
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.14340880
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.14340880
21Gait imbalance (HP:0002141)3.10395868
22Hematochezia (HP:0002573)3.03726695
23Dyschromatopsia (HP:0007641)3.03575005
24Gonadotropin excess (HP:0000837)2.98999193
25Biliary tract neoplasm (HP:0100574)2.98091560
26Birth length less than 3rd percentile (HP:0003561)2.89028611
27Cerebral hypomyelination (HP:0006808)2.88721764
28Tetraparesis (HP:0002273)2.86282829
29Mutism (HP:0002300)2.83522062
30Scotoma (HP:0000575)2.83466687
31Generalized tonic-clonic seizures (HP:0002069)2.82582058
32Shoulder girdle muscle weakness (HP:0003547)2.81017215
33Limb dystonia (HP:0002451)2.78375278
34Meningioma (HP:0002858)2.75341545
35Medial flaring of the eyebrow (HP:0010747)2.72254610
36Fair hair (HP:0002286)2.69938472
37Stomach cancer (HP:0012126)2.67239948
38Breast carcinoma (HP:0003002)2.66501381
39Congenital primary aphakia (HP:0007707)2.65118455
40Broad-based gait (HP:0002136)2.64883154
41Progressive inability to walk (HP:0002505)2.64830768
42Acute necrotizing encephalopathy (HP:0006965)2.62302766
43Disinhibition (HP:0000734)2.61469747
44Macroorchidism (HP:0000053)2.60790175
45Poor suck (HP:0002033)2.52163800
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48905463
47Abnormality of alanine metabolism (HP:0010916)2.48905463
48Hyperalaninemia (HP:0003348)2.48905463
49Nephrogenic diabetes insipidus (HP:0009806)2.45143777
50Hyperinsulinemic hypoglycemia (HP:0000825)2.44388311
51Polyphagia (HP:0002591)2.43757786
52Cone-rod dystrophy (HP:0000548)2.42665563
53Abnormal hair whorl (HP:0010721)2.42295184
54Methylmalonic acidemia (HP:0002912)2.41605166
55Abnormality of macular pigmentation (HP:0008002)2.39806385
56Azoospermia (HP:0000027)2.39780312
57Fetal akinesia sequence (HP:0001989)2.39713449
58Hypoglycemic seizures (HP:0002173)2.39636830
59Amblyopia (HP:0000646)2.30807761
60Genital tract atresia (HP:0001827)2.30383241
61Facial hemangioma (HP:0000329)2.30111636
62Drooling (HP:0002307)2.29014013
63Excessive salivation (HP:0003781)2.29014013
64Hypoglycemic coma (HP:0001325)2.28823948
65Progressive macrocephaly (HP:0004481)2.28675818
66Metaphyseal dysplasia (HP:0100255)2.27835598
67Esotropia (HP:0000565)2.27768788
68Hepatocellular necrosis (HP:0001404)2.26820877
69Mitochondrial inheritance (HP:0001427)2.26256418
70Amyotrophic lateral sclerosis (HP:0007354)2.25511955
71Aqueductal stenosis (HP:0002410)2.25247097
72Vaginal atresia (HP:0000148)2.24490752
73Neoplasm of the rectum (HP:0100743)2.23567155
74Type II lissencephaly (HP:0007260)2.23341344
75Tongue fasciculations (HP:0001308)2.23023317
76Hyperkalemia (HP:0002153)2.23008835
77Neoplasm of the tracheobronchial system (HP:0100552)2.21856278
78Unsteady gait (HP:0002317)2.21774613
79Inappropriate behavior (HP:0000719)2.21178986
80Inability to walk (HP:0002540)2.18245925
81Long nose (HP:0003189)2.18121625
82Neoplasm of the small intestine (HP:0100833)2.16605644
83Decreased circulating renin level (HP:0003351)2.15738268
84Abnormal mitochondria in muscle tissue (HP:0008316)2.15327704
85Abnormal spermatogenesis (HP:0008669)2.15189012
86Dysautonomia (HP:0002459)2.14098418
87Abnormal biliary tract morphology (HP:0012440)2.12539599
88Poor coordination (HP:0002370)2.12524266
89CNS hypomyelination (HP:0003429)2.10857527
90Hypothermia (HP:0002045)2.10728046
91Hyperventilation (HP:0002883)2.08258859
92Impaired vibration sensation in the lower limbs (HP:0002166)2.08083453
93Hip dysplasia (HP:0001385)2.07982375
94Hamartoma of the eye (HP:0010568)2.07340514
95Abnormality of the corticospinal tract (HP:0002492)2.07296599
96Chronic hepatic failure (HP:0100626)2.04800648
97Brittle hair (HP:0002299)2.04076920
98Nephronophthisis (HP:0000090)2.03795425
99Alveolar cell carcinoma (HP:0006519)2.03312142
100Transitional cell carcinoma of the bladder (HP:0006740)1.99976268
101Increased serum pyruvate (HP:0003542)1.99591903
102Abnormality of glycolysis (HP:0004366)1.99591903
103Pancreatic fibrosis (HP:0100732)1.98607571
104Abnormal eating behavior (HP:0100738)1.98298033
105Action tremor (HP:0002345)1.98251837
106Dysdiadochokinesis (HP:0002075)1.97920331
107Supranuclear gaze palsy (HP:0000605)1.97748834
108Abnormality of endocrine pancreas physiology (HP:0012093)1.96597170
109Abnormality of the pancreatic islet cells (HP:0006476)1.96597170
110Epileptiform EEG discharges (HP:0011182)1.96252474
111Neoplasm of the thyroid gland (HP:0100031)1.95376523
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94213694
113Truncal ataxia (HP:0002078)1.93873767
114Brushfield spots (HP:0001088)1.93278268
115Increased CSF lactate (HP:0002490)1.92105044
116Breast hypoplasia (HP:0003187)1.91830386
117Dynein arm defect of respiratory motile cilia (HP:0012255)1.91035926
118Absent/shortened dynein arms (HP:0200106)1.91035926
119Constricted visual fields (HP:0001133)1.90624184
120Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90575012
121Bladder neoplasm (HP:0009725)1.89947406
122Bladder carcinoma (HP:0002862)1.89947406
123Pancreatic cysts (HP:0001737)1.89153115
124Symptomatic seizures (HP:0011145)1.88894025
125EEG with generalized epileptiform discharges (HP:0011198)1.88740777
126Sleep apnea (HP:0010535)1.87951508
127Increased circulating renin level (HP:0000848)1.87830127
128Abnormality of the renal medulla (HP:0100957)1.87785775
129Pelvic girdle muscle weakness (HP:0003749)1.87212552
130Abnormality of methionine metabolism (HP:0010901)1.86994284
131Vacuolated lymphocytes (HP:0001922)1.86676420
132Uterine neoplasm (HP:0010784)1.85963905
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.85959461
134Concave nail (HP:0001598)1.85782304
135Horizontal nystagmus (HP:0000666)1.85650044
136Restlessness (HP:0000711)1.85501525
1373-Methylglutaconic aciduria (HP:0003535)1.84035202
138Cerebellar dysplasia (HP:0007033)1.83389485
139Specific learning disability (HP:0001328)1.83386417
140Abnormality of ocular smooth pursuit (HP:0000617)1.82004429
141Gaze-evoked nystagmus (HP:0000640)1.81753808
142Buphthalmos (HP:0000557)1.81484817
143Ulnar claw (HP:0001178)1.81026856
144Muscle fibrillation (HP:0010546)1.80295974
145Acute lymphatic leukemia (HP:0006721)1.79560996
146Abnormality of the musculature of the pelvis (HP:0001469)1.79220237
147Abnormality of the hip-girdle musculature (HP:0001445)1.79220237
148Impaired vibratory sensation (HP:0002495)1.79008870
149Abnormal autonomic nervous system physiology (HP:0012332)1.78720978
150Glioma (HP:0009733)1.78672130
151Progressive external ophthalmoplegia (HP:0000590)1.76658455
152Hyperthyroidism (HP:0000836)1.75424917
153Emotional lability (HP:0000712)1.74247574
154Termporal pattern (HP:0011008)1.73551488
155Insidious onset (HP:0003587)1.73551488
156Generalized hypopigmentation of hair (HP:0011358)1.73475786
157Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73232220
158Acute myeloid leukemia (HP:0004808)1.71672058
159Type I transferrin isoform profile (HP:0003642)1.71512857
160Furrowed tongue (HP:0000221)1.71218241
161Neoplasm of the adrenal cortex (HP:0100641)1.70773392
162Protruding tongue (HP:0010808)1.70234151
163Truncus arteriosus (HP:0001660)1.70101840
164Tubulointerstitial nephritis (HP:0001970)1.69579157
165Increased hepatocellular lipid droplets (HP:0006565)1.69011629
166Acute encephalopathy (HP:0006846)1.68837238
167Facial diplegia (HP:0001349)1.68719196
168Hyperglycemia (HP:0003074)1.68709245
169Muscle hypertrophy of the lower extremities (HP:0008968)1.68659208
170Rimmed vacuoles (HP:0003805)1.67871823
171Hypsarrhythmia (HP:0002521)1.67710184
172Premature ovarian failure (HP:0008209)1.67360666
173Stomatitis (HP:0010280)1.67108971
174Double outlet right ventricle (HP:0001719)1.65931174
175Congenital malformation of the right heart (HP:0011723)1.65931174
176Abnormality of vitamin B metabolism (HP:0004340)1.65766725
177Poor eye contact (HP:0000817)1.65207526
178Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.63213800
179Abnormal pupillary function (HP:0007686)1.62906014
180Molar tooth sign on MRI (HP:0002419)1.62600270
181Abnormality of midbrain morphology (HP:0002418)1.62600270
182True hermaphroditism (HP:0010459)1.62186239
183Pancreatic islet-cell hyperplasia (HP:0004510)1.61998774
184Abnormality of salivation (HP:0100755)1.61887079
185Ankle clonus (HP:0011448)1.60311191
186Ventricular fibrillation (HP:0001663)1.60183815
187Generalized myoclonic seizures (HP:0002123)1.59717229
188Retinal dysplasia (HP:0007973)1.59006116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.87847511
2EIF2AK33.75085297
3MAP3K93.56564277
4PBK3.50340234
5MARK13.32060380
6PNCK3.30033089
7NTRK33.09714473
8ARAF2.88109801
9CASK2.77470296
10NUAK12.66913974
11MAP3K122.50290158
12EPHA42.34653586
13MAP3K42.21406801
14MAP2K72.21303763
15MATK2.20791472
16ZAK2.18404691
17BRSK22.17949308
18MINK12.16222974
19PLK22.04624970
20PRKG22.03013612
21NME11.96402632
22GRK51.91947149
23MAPK131.71880603
24STK161.69346140
25RIPK41.63695822
26NLK1.60678137
27BMPR21.59629635
28TAF11.59484011
29BRAF1.56749977
30MST41.54760395
31KSR11.52823326
32TSSK61.51630300
33BUB11.47270138
34SCYL21.45875332
35PLK31.40727894
36STK31.36765586
37KSR21.34521460
38AKT31.34305771
39MAP2K41.30970134
40DYRK21.28852692
41BCR1.26235632
42LATS21.26205595
43WEE11.23993984
44TEC1.23844705
45PRKCG1.22119619
46STK38L1.21815505
47FGFR21.20376351
48TAOK31.18555992
49PAK61.18146608
50NTRK21.15203731
51MKNK21.14719780
52DYRK1A1.11604784
53MUSK1.11222333
54PLK41.03004913
55RAF11.01863889
56BMPR1B1.01361558
57TNIK0.98232063
58DYRK30.97929388
59CCNB10.97621622
60TRIM280.96381212
61LATS10.94878506
62DAPK10.94037273
63CAMK2A0.92972537
64MOS0.92713261
65CDK50.92276527
66WNK30.91399295
67CSNK1G20.90002264
68ERBB30.89907313
69DAPK20.89737686
70SRPK10.89546419
71KIT0.89270447
72PRKCQ0.87367775
73SIK20.87115895
74CDK140.86940565
75EIF2AK10.86675261
76NTRK10.86103273
77TRPM70.83942879
78FER0.83235921
79PHKG20.81355100
80PHKG10.81355100
81GRK70.81266561
82PINK10.80942806
83CSNK1G30.79778839
84CDK180.79103378
85YES10.78971794
86CLK10.77752834
87MKNK10.75666743
88MAP3K130.74546403
89CAMK2B0.73137853
90AURKA0.72799327
91CDK30.72615116
92CDK150.72294700
93CAMKK20.72045558
94RPS6KA40.70898407
95TTK0.70503941
96PTK2B0.70188253
97CDK190.69447070
98MAP3K20.68420326
99IRAK40.68346301
100PRKCE0.67222577
101MAP3K60.66971823
102PIK3CG0.64503202
103CDK11A0.64293321
104FLT30.63520976
105EIF2AK20.61821893
106CDK80.61411591
107GRK10.57015606
108IKBKB0.56493744
109FES0.55880289
110PAK30.55703059
111PRPF4B0.55156219
112VRK10.54927283
113PLK10.53478544
114MAP3K140.52615172
115ADRBK20.52111003
116PDK40.51270563
117PDK30.51270563
118SIK30.49676060
119CHEK20.49579360
120IRAK10.49391020
121OXSR10.49269633
122CAMK2D0.48731412
123CSNK1E0.48294203
124CAMK2G0.47931605
125ACVR1B0.47365192
126STK390.47266364
127CSF1R0.46976310
128RPS6KB10.46864659
129SGK4940.46646616
130SGK2230.46646616
131MAP2K10.45728924
132EGFR0.44319123
133PRKCI0.43993805
134MAP3K50.43809239
135TGFBR10.43424273
136UHMK10.42675850
137FGFR30.42477384
138LIMK10.42110833
139DMPK0.41990509
140IKBKE0.40829078
141TBK10.40604346
142PDK20.40442932
143ABL20.40117824
144CSNK1G10.39640404
145FGR0.39274495
146ABL10.39155913
147STK240.38930445
148MAPKAPK50.38851760
149BRSK10.38781471
150NEK10.38754785
151ERBB40.37233616
152MAPKAPK30.36219457
153PRKG10.33676975
154TXK0.29023171
155NEK90.28102828
156BRD40.27235122
157MARK30.24302020
158RPS6KB20.24050161
159FGFR10.23559503

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73007383
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18141819
3Non-homologous end-joining_Homo sapiens_hsa034502.62779562
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49571305
5Oxidative phosphorylation_Homo sapiens_hsa001902.46769093
6Collecting duct acid secretion_Homo sapiens_hsa049662.41369033
7GABAergic synapse_Homo sapiens_hsa047272.39115570
8Vitamin B6 metabolism_Homo sapiens_hsa007502.35646517
9Proteasome_Homo sapiens_hsa030502.32000252
10Long-term potentiation_Homo sapiens_hsa047202.31501342
11RNA polymerase_Homo sapiens_hsa030202.28306749
12Selenocompound metabolism_Homo sapiens_hsa004502.20584698
13Amphetamine addiction_Homo sapiens_hsa050312.11001913
14Glutamatergic synapse_Homo sapiens_hsa047242.06252513
15Circadian entrainment_Homo sapiens_hsa047132.05049776
16Morphine addiction_Homo sapiens_hsa050322.03243475
17Legionellosis_Homo sapiens_hsa051342.03147019
18Olfactory transduction_Homo sapiens_hsa047401.96983908
19Parkinsons disease_Homo sapiens_hsa050121.95128798
20Taste transduction_Homo sapiens_hsa047421.90730266
21Serotonergic synapse_Homo sapiens_hsa047261.89150301
22Dopaminergic synapse_Homo sapiens_hsa047281.86675840
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86590878
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85339071
25Nitrogen metabolism_Homo sapiens_hsa009101.84707628
26Oocyte meiosis_Homo sapiens_hsa041141.79544488
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.75314580
28Phototransduction_Homo sapiens_hsa047441.67890849
29Huntingtons disease_Homo sapiens_hsa050161.67480061
30Long-term depression_Homo sapiens_hsa047301.65086525
31Alzheimers disease_Homo sapiens_hsa050101.64887049
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62086064
33Caffeine metabolism_Homo sapiens_hsa002321.60132189
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59050694
35Inositol phosphate metabolism_Homo sapiens_hsa005621.58854762
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58676992
37Homologous recombination_Homo sapiens_hsa034401.56545631
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54775064
39Salivary secretion_Homo sapiens_hsa049701.52239358
40Platelet activation_Homo sapiens_hsa046111.50923332
41Vibrio cholerae infection_Homo sapiens_hsa051101.46722621
42Cholinergic synapse_Homo sapiens_hsa047251.46141422
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42465957
44Regulation of autophagy_Homo sapiens_hsa041401.36657658
45Insulin secretion_Homo sapiens_hsa049111.34615005
46Type II diabetes mellitus_Homo sapiens_hsa049301.32171378
47Glutathione metabolism_Homo sapiens_hsa004801.29864490
48Cardiac muscle contraction_Homo sapiens_hsa042601.28982639
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27060727
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25635087
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25489744
52Basal transcription factors_Homo sapiens_hsa030221.23207799
53Calcium signaling pathway_Homo sapiens_hsa040201.22368951
54Oxytocin signaling pathway_Homo sapiens_hsa049211.19973704
55Gap junction_Homo sapiens_hsa045401.18646055
56RNA transport_Homo sapiens_hsa030131.16538741
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15708116
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13154484
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12156204
60Cocaine addiction_Homo sapiens_hsa050301.10926108
61GnRH signaling pathway_Homo sapiens_hsa049121.10708722
62Propanoate metabolism_Homo sapiens_hsa006401.10657092
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10448647
64Asthma_Homo sapiens_hsa053101.09507826
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08835897
66Gastric acid secretion_Homo sapiens_hsa049711.06158363
67Renin secretion_Homo sapiens_hsa049241.05624450
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03943038
69Fanconi anemia pathway_Homo sapiens_hsa034600.95845658
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94246223
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93435096
72Peroxisome_Homo sapiens_hsa041460.93358978
73Purine metabolism_Homo sapiens_hsa002300.90249195
74p53 signaling pathway_Homo sapiens_hsa041150.88828855
75mTOR signaling pathway_Homo sapiens_hsa041500.87123744
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83327493
77Estrogen signaling pathway_Homo sapiens_hsa049150.82721959
78Melanogenesis_Homo sapiens_hsa049160.80900263
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78077407
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77283305
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.77199642
82Rheumatoid arthritis_Homo sapiens_hsa053230.76880746
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76264607
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75503636
85Axon guidance_Homo sapiens_hsa043600.75100419
86Pyrimidine metabolism_Homo sapiens_hsa002400.73442705
87Allograft rejection_Homo sapiens_hsa053300.72456318
88Circadian rhythm_Homo sapiens_hsa047100.70609212
89Sulfur metabolism_Homo sapiens_hsa009200.70171473
90Cell cycle_Homo sapiens_hsa041100.69194273
91Fatty acid elongation_Homo sapiens_hsa000620.68788704
92Prolactin signaling pathway_Homo sapiens_hsa049170.67758476
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.66540751
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66179213
95ErbB signaling pathway_Homo sapiens_hsa040120.65761811
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.65193888
97ABC transporters_Homo sapiens_hsa020100.63479587
98Lysosome_Homo sapiens_hsa041420.63210129
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62934215
100Ovarian steroidogenesis_Homo sapiens_hsa049130.62847006
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62760152
102Measles_Homo sapiens_hsa051620.61056752
103RNA degradation_Homo sapiens_hsa030180.60998673
104Herpes simplex infection_Homo sapiens_hsa051680.60812422
105cAMP signaling pathway_Homo sapiens_hsa040240.60529540
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.60397567
107Choline metabolism in cancer_Homo sapiens_hsa052310.60298707
108Malaria_Homo sapiens_hsa051440.58919996
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57932284
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.57524616
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56268957
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55983582
113Alcoholism_Homo sapiens_hsa050340.55897591
114Glioma_Homo sapiens_hsa052140.55711994
115Tuberculosis_Homo sapiens_hsa051520.54249063
116Spliceosome_Homo sapiens_hsa030400.53311221
117Pertussis_Homo sapiens_hsa051330.52946989
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.52245302
119N-Glycan biosynthesis_Homo sapiens_hsa005100.52095625
120Ether lipid metabolism_Homo sapiens_hsa005650.51808353
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51244677
122Hematopoietic cell lineage_Homo sapiens_hsa046400.50671228
123Hepatitis C_Homo sapiens_hsa051600.50488248
124Fatty acid degradation_Homo sapiens_hsa000710.49727119
125Pancreatic secretion_Homo sapiens_hsa049720.48212114
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47600317
127mRNA surveillance pathway_Homo sapiens_hsa030150.47347049
128Butanoate metabolism_Homo sapiens_hsa006500.47081893
129Ribosome_Homo sapiens_hsa030100.46465036
130Type I diabetes mellitus_Homo sapiens_hsa049400.45601709
131Phagosome_Homo sapiens_hsa041450.45281642
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43780053
133Ras signaling pathway_Homo sapiens_hsa040140.42763407
134Osteoclast differentiation_Homo sapiens_hsa043800.41226267
135Fatty acid biosynthesis_Homo sapiens_hsa000610.40823147
136Prion diseases_Homo sapiens_hsa050200.40392778
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38875375
138Fatty acid metabolism_Homo sapiens_hsa012120.38784674
139Chemical carcinogenesis_Homo sapiens_hsa052040.38225587
140Nucleotide excision repair_Homo sapiens_hsa034200.38163150
141Dorso-ventral axis formation_Homo sapiens_hsa043200.37810780
142MAPK signaling pathway_Homo sapiens_hsa040100.37618047
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37443004
144Mismatch repair_Homo sapiens_hsa034300.37029903
145Leishmaniasis_Homo sapiens_hsa051400.36922066
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36526747
147Epstein-Barr virus infection_Homo sapiens_hsa051690.35501500
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35224030
149TGF-beta signaling pathway_Homo sapiens_hsa043500.34834563
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.34444778
151African trypanosomiasis_Homo sapiens_hsa051430.32982815
152Renal cell carcinoma_Homo sapiens_hsa052110.32551324
153Thyroid hormone synthesis_Homo sapiens_hsa049180.31796471
154Sphingolipid metabolism_Homo sapiens_hsa006000.31602458
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.31284985
156Melanoma_Homo sapiens_hsa052180.30815976
157Protein export_Homo sapiens_hsa030600.29452554

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