SNX15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.48273563
2central nervous system myelination (GO:0022010)8.48273563
3fatty acid elongation (GO:0030497)6.21380314
4axon ensheathment (GO:0008366)5.35396130
5ensheathment of neurons (GO:0007272)5.35396130
6myelination (GO:0042552)5.27020575
7DNA deamination (GO:0045006)5.13237402
8protoporphyrinogen IX metabolic process (GO:0046501)5.08438732
9protoporphyrinogen IX biosynthetic process (GO:0006782)4.64958697
10L-fucose catabolic process (GO:0042355)4.64724322
11fucose catabolic process (GO:0019317)4.64724322
12L-fucose metabolic process (GO:0042354)4.64724322
13response to methylmercury (GO:0051597)4.52630304
14establishment of mitochondrion localization (GO:0051654)4.38058679
15negative regulation of telomere maintenance (GO:0032205)4.37407194
16long-chain fatty acid biosynthetic process (GO:0042759)4.24217350
17myelin maintenance (GO:0043217)4.22175257
18cholesterol biosynthetic process (GO:0006695)4.17835757
19heme biosynthetic process (GO:0006783)4.15939425
20oligodendrocyte differentiation (GO:0048709)4.02753309
21substantia nigra development (GO:0021762)4.00267246
22behavioral response to nicotine (GO:0035095)3.96447049
23regulation of collateral sprouting (GO:0048670)3.94757727
24negative regulation of neurotransmitter secretion (GO:0046929)3.85398091
25amyloid precursor protein metabolic process (GO:0042982)3.84091276
26porphyrin-containing compound biosynthetic process (GO:0006779)3.82487679
27creatine metabolic process (GO:0006600)3.82250323
28chaperone-mediated protein transport (GO:0072321)3.79373453
29sterol biosynthetic process (GO:0016126)3.71547614
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69773728
31presynaptic membrane organization (GO:0097090)3.63791019
32tetrapyrrole biosynthetic process (GO:0033014)3.63254609
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60412754
34autophagic vacuole fusion (GO:0000046)3.60189472
35regulation of autophagic vacuole assembly (GO:2000785)3.56587261
36phosphatidylinositol acyl-chain remodeling (GO:0036149)3.55647332
37positive regulation of defense response to virus by host (GO:0002230)3.55288199
38heme metabolic process (GO:0042168)3.49636100
39negative regulation of neurotransmitter transport (GO:0051589)3.45650683
40glutathione biosynthetic process (GO:0006750)3.42537555
41positive regulation of action potential (GO:0045760)3.42416133
42photoreceptor cell differentiation (GO:0046530)3.35200095
43eye photoreceptor cell differentiation (GO:0001754)3.35200095
44indole-containing compound catabolic process (GO:0042436)3.31737851
45indolalkylamine catabolic process (GO:0046218)3.31737851
46tryptophan catabolic process (GO:0006569)3.31737851
47platelet dense granule organization (GO:0060155)3.26578896
48nonribosomal peptide biosynthetic process (GO:0019184)3.22183223
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.21140885
50kynurenine metabolic process (GO:0070189)3.20164592
51porphyrin-containing compound metabolic process (GO:0006778)3.19943043
52magnesium ion transport (GO:0015693)3.18841417
53indolalkylamine metabolic process (GO:0006586)3.18363177
54long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.17171277
55negative regulation of execution phase of apoptosis (GO:1900118)3.16160872
56detection of light stimulus involved in sensory perception (GO:0050962)3.15488450
57detection of light stimulus involved in visual perception (GO:0050908)3.15488450
58cellular ketone body metabolic process (GO:0046950)3.15392610
59regulation of vacuole organization (GO:0044088)3.15021582
60energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12729280
61ATP synthesis coupled proton transport (GO:0015986)3.12729280
62presynaptic membrane assembly (GO:0097105)3.12054842
63peptidyl-cysteine modification (GO:0018198)3.11979453
64membrane tubulation (GO:0097320)3.10307850
65detection of temperature stimulus involved in sensory perception (GO:0050961)3.09625685
66detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.09625685
67amyloid precursor protein catabolic process (GO:0042987)3.08804931
68response to redox state (GO:0051775)3.08096239
69GPI anchor biosynthetic process (GO:0006506)3.07610395
70iron-sulfur cluster assembly (GO:0016226)3.07125175
71metallo-sulfur cluster assembly (GO:0031163)3.07125175
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.05398848
73positive regulation of fatty acid transport (GO:2000193)3.04902134
74isoprenoid biosynthetic process (GO:0008299)3.04740770
75negative regulation of mast cell activation (GO:0033004)3.02391987
76nucleotide transmembrane transport (GO:1901679)3.01909527
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.01907803
78protein palmitoylation (GO:0018345)3.00880015
79glycerophospholipid catabolic process (GO:0046475)2.99631223
80amine catabolic process (GO:0009310)2.99476681
81cellular biogenic amine catabolic process (GO:0042402)2.99476681
82opioid receptor signaling pathway (GO:0038003)2.99257085
83peptidyl-tyrosine autophosphorylation (GO:0038083)2.98323452
84adult walking behavior (GO:0007628)2.97757530
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96927299
86cellular response to epinephrine stimulus (GO:0071872)2.96487715
87adaptation of signaling pathway (GO:0023058)2.95884781
88response to pheromone (GO:0019236)2.93867431
89iron coordination entity transport (GO:1901678)2.93820664
90phosphatidylcholine acyl-chain remodeling (GO:0036151)2.93785596
91apical protein localization (GO:0045176)2.93504090
92tryptophan metabolic process (GO:0006568)2.92380837
93respiratory chain complex IV assembly (GO:0008535)2.91736397
94respiratory electron transport chain (GO:0022904)2.91479586
95organelle membrane fusion (GO:0090174)2.90260210
96protein polyglutamylation (GO:0018095)2.90198233
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88315904
98phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.88108709
99axon development (GO:0061564)2.87433181
100enteric nervous system development (GO:0048484)2.86951334
101electron transport chain (GO:0022900)2.86357995
102response to dietary excess (GO:0002021)2.85414990
103neuronal action potential propagation (GO:0019227)2.84253970
104response to lead ion (GO:0010288)2.82291908
105cytidine metabolic process (GO:0046087)2.82022318
106cytidine catabolic process (GO:0006216)2.82022318
107cytidine deamination (GO:0009972)2.82022318
108cornea development in camera-type eye (GO:0061303)2.81982015
109ketone body metabolic process (GO:1902224)2.81642713
110negative regulation of cAMP-mediated signaling (GO:0043951)2.80808791
111positive regulation of prostaglandin secretion (GO:0032308)2.78789359
112detection of temperature stimulus (GO:0016048)2.78690216
113inositol phosphate catabolic process (GO:0071545)2.78022957
114regulation of response to osmotic stress (GO:0047484)2.77651290
115peptide biosynthetic process (GO:0043043)2.76236541
116positive regulation of triglyceride biosynthetic process (GO:0010867)2.75198583
117neuronal ion channel clustering (GO:0045161)2.73913710
118astrocyte development (GO:0014002)2.73766831
119GPI anchor metabolic process (GO:0006505)2.73230358
120heme transport (GO:0015886)2.72887416
121regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70871866
122cytochrome complex assembly (GO:0017004)2.69944145
123signal peptide processing (GO:0006465)2.69276721
124phosphatidylserine acyl-chain remodeling (GO:0036150)2.68945797
125negative regulation of axonogenesis (GO:0050771)2.68856587
126piRNA metabolic process (GO:0034587)2.67779393
127proline transport (GO:0015824)2.66736420
128fatty-acyl-CoA metabolic process (GO:0035337)2.66099009
129adhesion of symbiont to host cell (GO:0044650)2.65795308
130virion attachment to host cell (GO:0019062)2.65795308
131negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.65622139
132regulation of lipoprotein metabolic process (GO:0050746)2.65619818
133fatty-acyl-CoA biosynthetic process (GO:0046949)2.65615508
134synaptic vesicle exocytosis (GO:0016079)2.65577306
135positive regulation of icosanoid secretion (GO:0032305)2.65267789
136regulation of memory T cell differentiation (GO:0043380)2.64750121
137detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64370234
138mitochondrial respiratory chain complex I assembly (GO:0032981)2.64365426
139NADH dehydrogenase complex assembly (GO:0010257)2.64365426
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64365426
141mitochondrion transport along microtubule (GO:0047497)2.63421925
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63421925
143regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63418846
144synaptic vesicle maturation (GO:0016188)2.62574505
145preassembly of GPI anchor in ER membrane (GO:0016254)2.62098508
146phosphorylated carbohydrate dephosphorylation (GO:0046838)2.62039630
147inositol phosphate dephosphorylation (GO:0046855)2.62039630
148protein complex biogenesis (GO:0070271)2.61811515
149positive regulation of T-helper 1 type immune response (GO:0002827)2.60508808
150neural nucleus development (GO:0048857)2.59316516
151protein maturation by protein folding (GO:0022417)2.58542080
152mannosylation (GO:0097502)2.58204893
153regulation of T-helper 2 cell differentiation (GO:0045628)2.55868873
154water-soluble vitamin biosynthetic process (GO:0042364)2.55597687
155nucleoside transmembrane transport (GO:1901642)2.53699522
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.53461463
157regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52451849
158response to lipoprotein particle (GO:0055094)2.52421338
159regulation of defense response to virus by host (GO:0050691)2.51173059
160NAD biosynthetic process (GO:0009435)2.50176933
161regulation of telomere maintenance (GO:0032204)2.49410618
162protein K6-linked ubiquitination (GO:0085020)2.49022992
163antigen processing and presentation of endogenous antigen (GO:0019883)2.48897702
164negative regulation of multicellular organism growth (GO:0040015)2.48409069
165parturition (GO:0007567)2.45808072
166polyol catabolic process (GO:0046174)2.45782325
167DNA methylation involved in gamete generation (GO:0043046)2.45252108
168ubiquinone biosynthetic process (GO:0006744)2.44575169
169glycine transport (GO:0015816)2.43298248
170negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.42407140
171purinergic nucleotide receptor signaling pathway (GO:0035590)2.41738127
172rhodopsin mediated signaling pathway (GO:0016056)2.38813645
173multicellular organism reproduction (GO:0032504)2.36784448
174oxidative demethylation (GO:0070989)2.36592580
175negative regulation of reactive oxygen species metabolic process (GO:2000378)2.36152033
176regulation of cilium movement (GO:0003352)2.35909610
177phosphatidylethanolamine metabolic process (GO:0046337)2.35115927
178indole-containing compound metabolic process (GO:0042430)2.35009354
179S-adenosylmethionine metabolic process (GO:0046500)2.34795437
180alanine transport (GO:0032328)2.34075557
181C-terminal protein lipidation (GO:0006501)2.33933372
182pyrimidine ribonucleoside catabolic process (GO:0046133)2.32859055
183phosphatidylethanolamine biosynthetic process (GO:0006646)2.32064998
184phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.31980324
185mitochondrial respiratory chain complex assembly (GO:0033108)2.31778144
186positive regulation of T cell mediated cytotoxicity (GO:0001916)2.31762152
187pseudouridine synthesis (GO:0001522)2.28215208
188anterograde synaptic vesicle transport (GO:0048490)2.26554765
189positive regulation of protein homooligomerization (GO:0032464)2.25384979
190regulation of hippo signaling (GO:0035330)2.24324407
191axoneme assembly (GO:0035082)2.24145578
192C-terminal protein amino acid modification (GO:0018410)2.23450391
193auditory receptor cell stereocilium organization (GO:0060088)2.23188635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.11677578
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.71674608
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.29046088
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.04365653
5ZNF274_21170338_ChIP-Seq_K562_Hela3.60286414
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.74561956
7GATA1_19941826_ChIP-Seq_K562_Human2.32762816
8SCL_19346495_ChIP-Seq_HPC-7_Human2.20203151
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98874084
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97475122
11THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96971520
12* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.92097366
13ERA_21632823_ChIP-Seq_H3396_Human1.90069937
14* TP53_22573176_ChIP-Seq_HFKS_Human1.89027533
15GATA1_19941827_ChIP-Seq_MEL_Mouse1.88521211
16RARB_27405468_Chip-Seq_BRAIN_Mouse1.87066264
17VDR_22108803_ChIP-Seq_LS180_Human1.86073604
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.81978822
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79636537
20* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73169551
21GBX2_23144817_ChIP-Seq_PC3_Human1.71942665
22BCL6_27268052_Chip-Seq_Bcells_Human1.71223441
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71004224
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68493153
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67881357
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67092072
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.66017613
28GATA3_21878914_ChIP-Seq_MCF-7_Human1.64914912
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63950787
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.63614319
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61273573
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61172758
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60937291
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.60176519
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60151373
36KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.58784196
37* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.57131405
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56638095
39TAF2_19829295_ChIP-Seq_ESCs_Human1.53377677
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51668762
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.51154101
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51001496
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.48101579
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47586167
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45827809
46P300_27268052_Chip-Seq_Bcells_Human1.45406317
47DROSHA_22980978_ChIP-Seq_HELA_Human1.44452601
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43711141
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43559987
50REST_21632747_ChIP-Seq_MESCs_Mouse1.41386686
51E2F1_20622854_ChIP-Seq_HELA_Human1.39981372
52* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38675814
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38572929
54STAT1_20625510_ChIP-Seq_HELA_Human1.38193253
55NCOR_22424771_ChIP-Seq_293T_Human1.37609227
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37035967
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36241415
58EOMES_21245162_ChIP-Seq_HESCs_Human1.35741228
59CTCF_20526341_ChIP-Seq_ESCs_Human1.35597610
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34692514
61RAC3_21632823_ChIP-Seq_H3396_Human1.34564865
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31568244
63HOXB7_26014856_ChIP-Seq_BT474_Human1.30467118
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29291247
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29088930
66AR_20517297_ChIP-Seq_VCAP_Human1.28504043
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.28364428
68GATA3_26560356_Chip-Seq_TH2_Human1.28005504
69* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27272724
70* FOXA1_25329375_ChIP-Seq_VCAP_Human1.27272724
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26390489
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25418516
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25400283
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25275891
75ER_23166858_ChIP-Seq_MCF-7_Human1.24995119
76* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24406795
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23436707
78NANOG_20526341_ChIP-Seq_ESCs_Human1.22542669
79PHF8_20622854_ChIP-Seq_HELA_Human1.21283647
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.21240474
81BCOR_27268052_Chip-Seq_Bcells_Human1.21050795
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20810278
83MYC_19829295_ChIP-Seq_ESCs_Human1.20347856
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20109118
85VDR_23849224_ChIP-Seq_CD4+_Human1.19373198
86P68_20966046_ChIP-Seq_HELA_Human1.19345662
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19078879
88CIITA_25753668_ChIP-Seq_RAJI_Human1.17789282
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17707694
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.16643311
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.16328701
92FOXH1_21741376_ChIP-Seq_ESCs_Human1.15748082
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15127150
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14990216
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14483505
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14235950
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14089029
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13874113
99CTCF_27219007_Chip-Seq_Bcells_Human1.13523835
100GATA2_19941826_ChIP-Seq_K562_Human1.13004276
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12898058
102OCT4_20526341_ChIP-Seq_ESCs_Human1.10850057
103* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10803135
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10699135
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10617617
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10251233
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10049435
108IRF1_19129219_ChIP-ChIP_H3396_Human1.09068007
109MYC_18940864_ChIP-ChIP_HL60_Human1.08587021
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.07139759
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06102659
112* P53_21459846_ChIP-Seq_SAOS-2_Human1.05679487
113ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04883078
114* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04287514
115* SA1_27219007_Chip-Seq_Bcells_Human1.04034392
116EZH2_27304074_Chip-Seq_ESCs_Mouse1.03359928
117IGF1R_20145208_ChIP-Seq_DFB_Human1.03124407
118OCT4_19829295_ChIP-Seq_ESCs_Human1.02863791
119CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02535466
120* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01121186
121CEBPB_22108803_ChIP-Seq_LS180_Human1.01090022
122* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00697102
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.00171741
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00156921
125SPI1_20517297_ChIP-Seq_HL60_Human1.00149066
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99921991
127* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99647188
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99575980
129FOXH1_21741376_ChIP-Seq_EPCs_Human0.98948535
130* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98522147
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98501789
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.98441677
133LXR_22292898_ChIP-Seq_THP-1_Human0.97441031
134EST1_17652178_ChIP-ChIP_JURKAT_Human0.97039595
135TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96677248
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95857620
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95764316
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95589074
139SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95194518
140ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94586827
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.93595904
142GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93493864
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.93306877
144CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93277546
145P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92866346
146MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92640320
147KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92508485
148TET1_21451524_ChIP-Seq_MESCs_Mouse0.92084088
149* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92034728
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91754729
151ETS1_20019798_ChIP-Seq_JURKAT_Human0.91028148
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90714778
153SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90032810
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89842233
155FOXP3_21729870_ChIP-Seq_TREG_Human0.89746894
156EZH2_22144423_ChIP-Seq_EOC_Human0.89301839
157GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88179897
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87274566
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86632595
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86460792
161ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85915481
162SA1_27219007_Chip-Seq_ERYTHROID_Human0.84843607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.43661255
2MP0003880_abnormal_central_pattern4.12764441
3MP0003656_abnormal_erythrocyte_physiolo3.71818051
4MP0004859_abnormal_synaptic_plasticity3.50520949
5MP0004147_increased_porphyrin_level3.42606574
6MP0004270_analgesia3.09755302
7MP0001529_abnormal_vocalization2.99795497
8MP0001905_abnormal_dopamine_level2.72478152
9MP0003329_amyloid_beta_deposits2.64480078
10MP0002272_abnormal_nervous_system2.62792466
11MP0003787_abnormal_imprinting2.58171669
12MP0002653_abnormal_ependyma_morphology2.43109371
13MP0002064_seizures2.39692508
14MP0006292_abnormal_olfactory_placode2.37562234
15MP0005645_abnormal_hypothalamus_physiol2.30741311
16MP0004142_abnormal_muscle_tone2.28512911
17MP0004043_abnormal_pH_regulation2.24966081
18MP0003646_muscle_fatigue2.21926006
19MP0005646_abnormal_pituitary_gland2.19504858
20MP0001968_abnormal_touch/_nociception2.15758684
21MP0008877_abnormal_DNA_methylation2.15635302
22MP0009745_abnormal_behavioral_response2.11030127
23MP0002734_abnormal_mechanical_nocicepti2.10029506
24MP0003011_delayed_dark_adaptation2.01229279
25MP0001970_abnormal_pain_threshold2.01169549
26MP0003635_abnormal_synaptic_transmissio1.99682410
27MP0003690_abnormal_glial_cell1.99462934
28MP0002138_abnormal_hepatobiliary_system1.98715194
29MP0008260_abnormal_autophagy1.98663324
30MP0003634_abnormal_glial_cell1.91527751
31MP0001986_abnormal_taste_sensitivity1.89329756
32MP0002102_abnormal_ear_morphology1.86733411
33MP0002733_abnormal_thermal_nociception1.86563951
34MP0001835_abnormal_antigen_presentation1.85874372
35MP0000462_abnormal_digestive_system1.84932788
36MP0002736_abnormal_nociception_after1.84417269
37MP0002735_abnormal_chemical_nociception1.83605236
38MP0002876_abnormal_thyroid_physiology1.81527244
39MP0004742_abnormal_vestibular_system1.81304066
40MP0002229_neurodegeneration1.79060638
41MP0008872_abnormal_physiological_respon1.75721758
42MP0002837_dystrophic_cardiac_calcinosis1.75099471
43MP0000685_abnormal_immune_system1.68431907
44MP0009046_muscle_twitch1.67879125
45MP0001486_abnormal_startle_reflex1.65798290
46MP0005671_abnormal_response_to1.65471988
47MP0004885_abnormal_endolymph1.64095855
48MP0003195_calcinosis1.63962812
49MP0001873_stomach_inflammation1.63476609
50MP0002572_abnormal_emotion/affect_behav1.61760878
51MP0001440_abnormal_grooming_behavior1.61275555
52MP0005171_absent_coat_pigmentation1.60911485
53MP0008875_abnormal_xenobiotic_pharmacok1.52922386
54MP0002638_abnormal_pupillary_reflex1.51572478
55MP0002063_abnormal_learning/memory/cond1.50071610
56MP0003806_abnormal_nucleotide_metabolis1.49511730
57MP0000372_irregular_coat_pigmentation1.47576986
58MP0009840_abnormal_foam_cell1.43988550
59MP0003633_abnormal_nervous_system1.43667070
60MP0001485_abnormal_pinna_reflex1.40731023
61MP0002163_abnormal_gland_morphology1.39189599
62MP0005083_abnormal_biliary_tract1.38477188
63MP0005058_abnormal_lysosome_morphology1.36578127
64MP0005551_abnormal_eye_electrophysiolog1.35657597
65MP0008569_lethality_at_weaning1.35089478
66MP0001790_abnormal_immune_system1.34117457
67MP0005387_immune_system_phenotype1.34117457
68MP0009764_decreased_sensitivity_to1.33990770
69MP0000604_amyloidosis1.33727701
70MP0005451_abnormal_body_composition1.33137206
71MP0002148_abnormal_hypersensitivity_rea1.33031254
72MP0006036_abnormal_mitochondrial_physio1.32564402
73MP0001800_abnormal_humoral_immune1.32330093
74MP0000569_abnormal_digit_pigmentation1.29846234
75MP0004145_abnormal_muscle_electrophysio1.29728282
76MP0003631_nervous_system_phenotype1.28758534
77MP0005174_abnormal_tail_pigmentation1.27992910
78MP0002066_abnormal_motor_capabilities/c1.25093473
79MP0002928_abnormal_bile_duct1.22138542
80MP0002067_abnormal_sensory_capabilities1.21894847
81MP0002723_abnormal_immune_serum1.21138764
82MP0000955_abnormal_spinal_cord1.20166539
83MP0002882_abnormal_neuron_morphology1.20075848
84MP0005365_abnormal_bile_salt1.18039884
85MP0005670_abnormal_white_adipose1.16233724
86MP0000015_abnormal_ear_pigmentation1.13074469
87MP0000778_abnormal_nervous_system1.11751888
88MP0002693_abnormal_pancreas_physiology1.11584060
89MP0003724_increased_susceptibility_to1.10213716
90MP0003632_abnormal_nervous_system1.09605669
91MP0006072_abnormal_retinal_apoptosis1.07927891
92MP0005075_abnormal_melanosome_morpholog1.07852536
93MP0005386_behavior/neurological_phenoty1.07802126
94MP0004924_abnormal_behavior1.07802126
95MP0002420_abnormal_adaptive_immunity1.07225862
96MP0001819_abnormal_immune_cell1.06587577
97MP0002822_catalepsy1.06186160
98MP0000747_muscle_weakness1.05325053
99MP0002452_abnormal_antigen_presenting1.04242796
100MP0000427_abnormal_hair_cycle1.03030599
101MP0000631_abnormal_neuroendocrine_gland1.01085473
102MP0005423_abnormal_somatic_nervous1.00275248
103MP0004811_abnormal_neuron_physiology0.99922724
104MP0002751_abnormal_autonomic_nervous0.99502134
105MP0005409_darkened_coat_color0.98217022
106MP0001764_abnormal_homeostasis0.97790147
107MP0005000_abnormal_immune_tolerance0.97637134
108MP0004130_abnormal_muscle_cell0.97409434
109MP0000749_muscle_degeneration0.97116297
110MP0005410_abnormal_fertilization0.94757079
111MP0005448_abnormal_energy_balance0.94444217
112MP0010329_abnormal_lipoprotein_level0.93874474
113MP0009785_altered_susceptibility_to0.92006507
114MP0005332_abnormal_amino_acid0.90413743
115MP0003172_abnormal_lysosome_physiology0.90223223
116MP0006276_abnormal_autonomic_nervous0.89961314
117MP0005636_abnormal_mineral_homeostasis0.89340503
118MP0003950_abnormal_plasma_membrane0.89251792
119MP0005025_abnormal_response_to0.88648169
120MP0010386_abnormal_urinary_bladder0.86698818
121MP0003075_altered_response_to0.86352508
122MP0002938_white_spotting0.86077913
123MP0001663_abnormal_digestive_system0.85881280
124MP0002090_abnormal_vision0.85626105
125MP0001963_abnormal_hearing_physiology0.84647785
126MP0001502_abnormal_circadian_rhythm0.84437101
127MP0002752_abnormal_somatic_nervous0.84412614
128MP0005085_abnormal_gallbladder_physiolo0.83782938
129MP0003137_abnormal_impulse_conducting0.83492079
130MP0008874_decreased_physiological_sensi0.82996679
131MP0005084_abnormal_gallbladder_morpholo0.82968127
132MP0006082_CNS_inflammation0.82362459
133MP0001919_abnormal_reproductive_system0.82107956
134MP0005584_abnormal_enzyme/coenzyme_acti0.81520672
135MP0002095_abnormal_skin_pigmentation0.80767378
136MP0001765_abnormal_ion_homeostasis0.78867984
137MP0005310_abnormal_salivary_gland0.77678381
138MP0000230_abnormal_systemic_arterial0.77380954
139MP0003879_abnormal_hair_cell0.75976899
140MP0008789_abnormal_olfactory_epithelium0.75713203
141MP0000716_abnormal_immune_system0.75141420
142MP0001501_abnormal_sleep_pattern0.75034795
143MP0008995_early_reproductive_senescence0.75026822
144MP0000639_abnormal_adrenal_gland0.71004509
145MP0002557_abnormal_social/conspecific_i0.70538234
146MP0003186_abnormal_redox_activity0.70513468
147MP0005379_endocrine/exocrine_gland_phen0.69654956
148MP0001188_hyperpigmentation0.68240687
149MP0003122_maternal_imprinting0.67566305
150MP0009333_abnormal_splenocyte_physiolog0.67443844
151MP0005195_abnormal_posterior_eye0.67388192
152MP0000013_abnormal_adipose_tissue0.66914824
153MP0005253_abnormal_eye_physiology0.66851654
154MP0003183_abnormal_peptide_metabolism0.65463387
155MP0009765_abnormal_xenobiotic_induced0.65006439
156MP0008873_increased_physiological_sensi0.63581805
157MP0004133_heterotaxia0.62731421
158MP0001984_abnormal_olfaction0.62633154
159MP0001346_abnormal_lacrimal_gland0.61304440
160MP0000003_abnormal_adipose_tissue0.60166318
161MP0002184_abnormal_innervation0.59990721

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)5.21038655
2Sensory axonal neuropathy (HP:0003390)4.91312920
3Congenital stationary night blindness (HP:0007642)4.83044866
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.33685921
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.33685921
6Neurofibrillary tangles (HP:0002185)4.31579024
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.08021774
8Stomatitis (HP:0010280)3.93875823
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.84248068
10Abnormality of midbrain morphology (HP:0002418)3.75421369
11Molar tooth sign on MRI (HP:0002419)3.75421369
12Peripheral hypomyelination (HP:0007182)3.69648517
13Myokymia (HP:0002411)3.68081641
14Abnormal rod and cone electroretinograms (HP:0008323)3.56912121
15Parakeratosis (HP:0001036)3.42836564
16Spastic paraparesis (HP:0002313)3.41991741
17Abnormality of glycolysis (HP:0004366)3.34630056
18Increased serum pyruvate (HP:0003542)3.34630056
19Pancreatic cysts (HP:0001737)3.29378605
20Retinal dysplasia (HP:0007973)3.18609143
21Leukodystrophy (HP:0002415)3.16704802
22Abnormality of the corticospinal tract (HP:0002492)3.16047169
23Spastic gait (HP:0002064)3.11144754
24Supranuclear gaze palsy (HP:0000605)3.08448106
25Hepatocellular necrosis (HP:0001404)3.02325440
26Decreased electroretinogram (ERG) amplitude (HP:0000654)2.99557788
27Acute necrotizing encephalopathy (HP:0006965)2.99041641
28Cerebral inclusion bodies (HP:0100314)2.94020964
29Attenuation of retinal blood vessels (HP:0007843)2.93123496
30Scanning speech (HP:0002168)2.85860606
31CNS hypomyelination (HP:0003429)2.84147912
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.82881313
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79683230
34Nephronophthisis (HP:0000090)2.75143156
35Mitochondrial inheritance (HP:0001427)2.74367637
36Pancreatic fibrosis (HP:0100732)2.74005548
37True hermaphroditism (HP:0010459)2.69253398
38Elevated erythrocyte sedimentation rate (HP:0003565)2.69041323
39Onion bulb formation (HP:0003383)2.68843516
40Hyperventilation (HP:0002883)2.67961334
41Dysmetria (HP:0001310)2.67439945
42Stomach cancer (HP:0012126)2.65502672
43Abnormal mitochondria in muscle tissue (HP:0008316)2.64271594
44Epileptic encephalopathy (HP:0200134)2.63087396
45Abnormality of the renal cortex (HP:0011035)2.62648433
46Progressive microcephaly (HP:0000253)2.61437517
47Abolished electroretinogram (ERG) (HP:0000550)2.59970769
48Slow saccadic eye movements (HP:0000514)2.57678144
493-Methylglutaconic aciduria (HP:0003535)2.57546258
50Ankle clonus (HP:0011448)2.57331605
51Acute encephalopathy (HP:0006846)2.54319692
52Poor suck (HP:0002033)2.53061890
53Intention tremor (HP:0002080)2.52997028
54Large for gestational age (HP:0001520)2.52981110
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.51267841
56Severe visual impairment (HP:0001141)2.47391033
57Hepatic necrosis (HP:0002605)2.46655489
58Abnormal drinking behavior (HP:0030082)2.45936590
59Polydipsia (HP:0001959)2.45936590
60Type II lissencephaly (HP:0007260)2.45769861
61Inability to walk (HP:0002540)2.44591831
62Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43869825
63Abnormal auditory evoked potentials (HP:0006958)2.41614214
64Abnormal gallbladder morphology (HP:0012437)2.39372366
65Abnormality of the renal medulla (HP:0100957)2.38109432
66Clumsiness (HP:0002312)2.38094427
67Medial flaring of the eyebrow (HP:0010747)2.36407443
68Increased circulating renin level (HP:0000848)2.34166977
69Atonic seizures (HP:0010819)2.33273569
70Poikilocytosis (HP:0004447)2.32258015
71Pheochromocytoma (HP:0002666)2.30709883
72Neuroendocrine neoplasm (HP:0100634)2.28656697
73Diaphragmatic weakness (HP:0009113)2.26996326
74Anteriorly placed anus (HP:0001545)2.26604116
75Methylmalonic acidemia (HP:0002912)2.26004041
76Bony spicule pigmentary retinopathy (HP:0007737)2.23995904
77Chronic mucocutaneous candidiasis (HP:0002728)2.23548539
78Recurrent cutaneous fungal infections (HP:0011370)2.23548539
79Paraparesis (HP:0002385)2.22881827
80Stridor (HP:0010307)2.22765370
81Abnormality of magnesium homeostasis (HP:0004921)2.21374999
82Decreased central vision (HP:0007663)2.20482669
83Abnormality of alanine metabolism (HP:0010916)2.20025442
84Hyperalaninemia (HP:0003348)2.20025442
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20025442
86Poor speech (HP:0002465)2.18310953
87Progressive macrocephaly (HP:0004481)2.16228663
88Cerebral hemorrhage (HP:0001342)2.15508197
89Abnormal gallbladder physiology (HP:0012438)2.15376691
90Cholecystitis (HP:0001082)2.15376691
91Akinesia (HP:0002304)2.15122829
92Progressive neurologic deterioration (HP:0002344)2.15106847
93Increased CSF lactate (HP:0002490)2.14701869
94Alacrima (HP:0000522)2.13589435
95Limb dystonia (HP:0002451)2.12852344
96Renal Fanconi syndrome (HP:0001994)2.12458263
97Progressive inability to walk (HP:0002505)2.11180098
98Absent speech (HP:0001344)2.10503345
99Cystic liver disease (HP:0006706)2.09348786
100Gaze-evoked nystagmus (HP:0000640)2.07790387
101Cholelithiasis (HP:0001081)2.06504118
102Agammaglobulinemia (HP:0004432)2.05391416
103Severe muscular hypotonia (HP:0006829)2.04774060
104Morphological abnormality of the inner ear (HP:0011390)2.04725241
105Chronic hepatic failure (HP:0100626)2.04661823
106Thyroid-stimulating hormone excess (HP:0002925)2.03788066
107Progressive cerebellar ataxia (HP:0002073)2.03245987
108Choreoathetosis (HP:0001266)2.03063522
109Panhypogammaglobulinemia (HP:0003139)2.02717657
110Thickened helices (HP:0000391)2.02469201
111Paralysis (HP:0003470)2.01323024
112Polyuria (HP:0000103)2.00710629
113Acanthocytosis (HP:0001927)1.99627162
114Albinism (HP:0001022)1.99478361
115Abnormal biliary tract physiology (HP:0012439)1.99375876
116Bile duct proliferation (HP:0001408)1.99375876
117Aplasia/Hypoplasia of the fovea (HP:0008060)1.98685314
118Hypoplasia of the fovea (HP:0007750)1.98685314
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.98020832
120Neoplasm of the adrenal cortex (HP:0100641)1.97950366
121Decreased circulating renin level (HP:0003351)1.97863155
122Delusions (HP:0000746)1.97697074
123Congenital ichthyosiform erythroderma (HP:0007431)1.97494526
124Increased serum lactate (HP:0002151)1.96718328
125Hypochromic anemia (HP:0001931)1.94738645
126Premature skin wrinkling (HP:0100678)1.94617371
127Sclerocornea (HP:0000647)1.93278100
128Bulbous nose (HP:0000414)1.92946080
129Constricted visual fields (HP:0001133)1.91633530
130Ketosis (HP:0001946)1.91268776
131Anxiety (HP:0000739)1.91027619
132Emotional lability (HP:0000712)1.90860781
133Recurrent fungal infections (HP:0002841)1.89878209
134Abnormal eating behavior (HP:0100738)1.89523070
135Opisthotonus (HP:0002179)1.89378594
136Focal motor seizures (HP:0011153)1.88731627
137Cutaneous photosensitivity (HP:0000992)1.88366649
138Renal cortical cysts (HP:0000803)1.88015611
139Pachygyria (HP:0001302)1.87920232
140Amelogenesis imperfecta (HP:0000705)1.87292914
141Hypomagnesemia (HP:0002917)1.87194107
142Tubular atrophy (HP:0000092)1.87065001
143Abnormality of macular pigmentation (HP:0008002)1.86890098
144Hyperglycinuria (HP:0003108)1.86794982
145Purpura (HP:0000979)1.86585301
146Generalized myoclonic seizures (HP:0002123)1.84992841
147Abnormality of T cell physiology (HP:0011840)1.84529474
148Psychosis (HP:0000709)1.83613316
149Methylmalonic aciduria (HP:0012120)1.83486895
150Pendular nystagmus (HP:0012043)1.83344252
151Increased hepatocellular lipid droplets (HP:0006565)1.81670883
152Muscular hypotonia of the trunk (HP:0008936)1.81341094
153Encephalitis (HP:0002383)1.81184659
154Hemiparesis (HP:0001269)1.81122127
155IgG deficiency (HP:0004315)1.81041660
156Lissencephaly (HP:0001339)1.80661187
157Respiratory failure (HP:0002878)1.80558200
158Chronic otitis media (HP:0000389)1.80517133
159Clonus (HP:0002169)1.79581810
160Cerebellar dysplasia (HP:0007033)1.79449319
161Hyperbilirubinemia (HP:0002904)1.79179273
162Hepatosplenomegaly (HP:0001433)1.78393431
163Hypothermia (HP:0002045)1.78226294
164Segmental peripheral demyelination/remyelination (HP:0003481)1.76914019
165Retinitis pigmentosa (HP:0000510)1.76832979
166Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76792247
167Optic neuritis (HP:0100653)1.76176505
168Retrobulbar optic neuritis (HP:0100654)1.76176505
169Aplasia/Hypoplasia of the spleen (HP:0010451)1.75944973
170Insidious onset (HP:0003587)1.75761603
171Termporal pattern (HP:0011008)1.75761603
172Visual hallucinations (HP:0002367)1.75639266
173Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75300344
174Gait imbalance (HP:0002141)1.75036153
175Episodic fever (HP:0001954)1.74404837
176Cortical visual impairment (HP:0100704)1.74175978
177Optic disc pallor (HP:0000543)1.74077719
178Abnormal number of erythroid precursors (HP:0012131)1.73733898
179Febrile seizures (HP:0002373)1.73532967
180Rigidity (HP:0002063)1.72555972
181Broad-based gait (HP:0002136)1.71466095
182Cerebral palsy (HP:0100021)1.71361051
183Postnatal microcephaly (HP:0005484)1.70741240
184Lipid accumulation in hepatocytes (HP:0006561)1.68382324
185Vacuolated lymphocytes (HP:0001922)1.68375858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.83964093
2STK394.05103991
3MAP4K23.66283034
4OXSR13.41826586
5MAP3K133.29693187
6TNIK3.20897590
7CDK193.20288811
8ZAK3.13945947
9TAOK33.06186138
10BMPR1B2.69864080
11ARAF2.62604686
12GRK12.52260004
13EPHB12.39508732
14STK162.36791168
15MAPK152.25784473
16UHMK12.22904348
17MAPKAPK52.11410148
18NUAK12.05147398
19TNK22.01799542
20ICK1.97223492
21LIMK11.94923725
22PKN11.91905531
23BCR1.88635841
24WNK41.88592848
25TXK1.85965962
26CSNK1G31.79745488
27PBK1.79105654
28MAPKAPK31.73015717
29TESK21.71563219
30NTRK11.64941710
31CAMK2B1.58004605
32IKBKB1.55949358
33CASK1.55843995
34VRK21.44301646
35MST41.43771844
36ADRBK21.41681683
37CSNK1A1L1.38628474
38KIT1.36635190
39PRPF4B1.34932599
40KSR21.34831720
41INSRR1.28558257
42ACVR1B1.25931254
43CAMK2D1.24043438
44CSNK1G11.23242266
45BRAF1.21585815
46CSNK1G21.21155876
47MET1.19280346
48WNK31.16750212
49CDK141.12793351
50PHKG11.12051590
51PHKG21.12051590
52MAP3K91.10950707
53PTK2B1.10019633
54ADRBK11.09035257
55SGK2231.07478025
56SGK4941.07478025
57CAMK2G1.07359737
58ROCK21.06183193
59EPHA41.05116366
60CLK11.03508187
61PAK61.03307496
62PRKD21.03129616
63SIK30.99947033
64CDK150.98497393
65HIPK20.97127058
66CDK180.97025245
67MARK20.96216106
68ERN10.95738704
69CDK11A0.92593706
70PRKCI0.91315908
71MARK30.89458084
72NEK60.89195039
73MAP3K10.85799469
74MAP2K60.84918929
75RAF10.84743489
76TLK10.82514879
77IRAK20.82308723
78BTK0.82092435
79WNK10.81082697
80MAP4K10.79242342
81CDK50.78502019
82CAMKK20.77433784
83NME10.76856067
84MAPK110.76449309
85GRK50.76369908
86ITK0.74970669
87GRK70.72208420
88STK110.69946765
89PDPK10.67979069
90DYRK20.67204424
91RPS6KA50.66945402
92CAMK2A0.66675968
93IRAK10.64808396
94MAP2K20.64473462
95PRKCQ0.64296144
96CHUK0.63516796
97PRKCZ0.63384185
98MAP3K110.62666093
99TBK10.61915531
100PAK10.61861462
101STK40.61570743
102PIM20.61281146
103LYN0.59686280
104ILK0.59345813
105PRKAA20.59183878
106DAPK30.59059944
107CAMK10.59044904
108MUSK0.57500919
109NTRK30.55597680
110HCK0.54405485
111TEC0.54219731
112MOS0.53102570
113LRRK20.52825512
114VRK10.52443261
115PRKCE0.52334897
116FES0.52002192
117PIK3CG0.51497858
118RPS6KA60.50547282
119TAOK10.50042066
120SIK20.49972778
121MATK0.49170065
122PRKD10.49137076
123TYK20.49043293
124MAPK130.47970315
125IKBKE0.47687285
126PRKAA10.47493193
127DAPK20.47048626
128CSF1R0.47044231
129MAP2K10.46724250
130TYRO30.46063100
131EIF2AK10.45315337
132MARK10.44805797
133PDK10.44469787
134LCK0.43794379
135PRKACA0.43349724
136PINK10.42912565
137PAK30.42530963
138IRAK40.41052407
139BLK0.41044309
140CDK80.40277303
141PIM10.40134003
142BCKDK0.38125359
143MAP3K40.37715641
144GRK60.35779021
145FGR0.35752872
146NTRK20.34079443
147PRKD30.33488058
148TGFBR10.31867708
149JAK30.31648723
150CSNK1A10.31391366
151KDR0.30808109
152FYN0.30350540
153CCNB10.29831235
154FGFR20.29329900
155RIPK40.29168546
156SYK0.29068640
157MAP3K70.29065600
158PRKCG0.28599527
159PRKCA0.28383139
160AURKA0.26925491

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.84995162
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.96107236
3Fatty acid elongation_Homo sapiens_hsa000623.49846611
4Oxidative phosphorylation_Homo sapiens_hsa001903.38780743
5Protein export_Homo sapiens_hsa030603.22883658
6Phototransduction_Homo sapiens_hsa047443.02685907
7Steroid biosynthesis_Homo sapiens_hsa001002.95346266
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.74204107
9Parkinsons disease_Homo sapiens_hsa050122.69268848
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.67152098
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.63860406
12Nitrogen metabolism_Homo sapiens_hsa009102.62847211
13Vitamin B6 metabolism_Homo sapiens_hsa007502.40967736
14Sulfur metabolism_Homo sapiens_hsa009202.40453044
15Ether lipid metabolism_Homo sapiens_hsa005652.37306424
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.33068106
17Caffeine metabolism_Homo sapiens_hsa002322.20773609
18Alzheimers disease_Homo sapiens_hsa050102.19190984
19Collecting duct acid secretion_Homo sapiens_hsa049662.17362326
20Asthma_Homo sapiens_hsa053102.02469031
21Primary immunodeficiency_Homo sapiens_hsa053402.00962635
22Allograft rejection_Homo sapiens_hsa053301.99861809
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.93900329
24Synaptic vesicle cycle_Homo sapiens_hsa047211.92988610
25Regulation of autophagy_Homo sapiens_hsa041401.91741412
26Graft-versus-host disease_Homo sapiens_hsa053321.84089207
27Autoimmune thyroid disease_Homo sapiens_hsa053201.77979568
28GABAergic synapse_Homo sapiens_hsa047271.71341864
29Type I diabetes mellitus_Homo sapiens_hsa049401.68767418
30Vibrio cholerae infection_Homo sapiens_hsa051101.66028942
31Tryptophan metabolism_Homo sapiens_hsa003801.63660207
32Sphingolipid metabolism_Homo sapiens_hsa006001.59898655
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54366491
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50926020
35Huntingtons disease_Homo sapiens_hsa050161.49098291
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48538828
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40508278
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39013830
39Serotonergic synapse_Homo sapiens_hsa047261.32724102
40Cocaine addiction_Homo sapiens_hsa050301.31506898
41Homologous recombination_Homo sapiens_hsa034401.26229613
42Linoleic acid metabolism_Homo sapiens_hsa005911.24122199
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23695007
44Folate biosynthesis_Homo sapiens_hsa007901.22368697
45Morphine addiction_Homo sapiens_hsa050321.22073806
46Selenocompound metabolism_Homo sapiens_hsa004501.19260428
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16720586
48Butanoate metabolism_Homo sapiens_hsa006501.15575124
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.14369145
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12330186
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11109323
52Cardiac muscle contraction_Homo sapiens_hsa042601.10686981
53Glutamatergic synapse_Homo sapiens_hsa047241.10627329
54Long-term depression_Homo sapiens_hsa047301.06862730
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02756863
56Lysosome_Homo sapiens_hsa041421.02177767
57Histidine metabolism_Homo sapiens_hsa003400.99602001
58Alcoholism_Homo sapiens_hsa050340.99137744
59Fat digestion and absorption_Homo sapiens_hsa049750.98135981
60Circadian entrainment_Homo sapiens_hsa047130.94476374
61Antigen processing and presentation_Homo sapiens_hsa046120.94239170
62Fanconi anemia pathway_Homo sapiens_hsa034600.93984844
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92476707
64Glycerolipid metabolism_Homo sapiens_hsa005610.88134783
65Sulfur relay system_Homo sapiens_hsa041220.87573444
66Cholinergic synapse_Homo sapiens_hsa047250.86976434
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85801889
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83717253
69Glutathione metabolism_Homo sapiens_hsa004800.82243882
70Rheumatoid arthritis_Homo sapiens_hsa053230.81835527
71One carbon pool by folate_Homo sapiens_hsa006700.78774922
72Dopaminergic synapse_Homo sapiens_hsa047280.78307825
73Insulin secretion_Homo sapiens_hsa049110.77189350
74Endocytosis_Homo sapiens_hsa041440.75382566
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75092918
76Arginine and proline metabolism_Homo sapiens_hsa003300.73177619
77Nicotine addiction_Homo sapiens_hsa050330.71324171
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70149407
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.70138068
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.68597245
81Axon guidance_Homo sapiens_hsa043600.67099775
82Renal cell carcinoma_Homo sapiens_hsa052110.65318745
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63795175
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63758762
85Arachidonic acid metabolism_Homo sapiens_hsa005900.63100479
86Taste transduction_Homo sapiens_hsa047420.61335914
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61181833
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.60878932
89Proteasome_Homo sapiens_hsa030500.60595197
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59622885
91Phagosome_Homo sapiens_hsa041450.59532126
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.59196492
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.58538601
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58346817
95Salivary secretion_Homo sapiens_hsa049700.58148247
96Propanoate metabolism_Homo sapiens_hsa006400.57614402
97Basal transcription factors_Homo sapiens_hsa030220.56778524
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56516953
99Hematopoietic cell lineage_Homo sapiens_hsa046400.55498431
100Gap junction_Homo sapiens_hsa045400.55306464
101Metabolic pathways_Homo sapiens_hsa011000.53701510
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.52424843
103Pancreatic secretion_Homo sapiens_hsa049720.51931496
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51916609
105Staphylococcus aureus infection_Homo sapiens_hsa051500.51169833
106Calcium signaling pathway_Homo sapiens_hsa040200.49925758
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.48804734
108Fatty acid metabolism_Homo sapiens_hsa012120.46838609
109Amphetamine addiction_Homo sapiens_hsa050310.45904714
110Leishmaniasis_Homo sapiens_hsa051400.45703646
111Other glycan degradation_Homo sapiens_hsa005110.44050399
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.43550587
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40814308
114Long-term potentiation_Homo sapiens_hsa047200.40297458
115Vitamin digestion and absorption_Homo sapiens_hsa049770.38213620
116Peroxisome_Homo sapiens_hsa041460.37461233
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36651684
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36473577
119Ras signaling pathway_Homo sapiens_hsa040140.35323459
120Pyruvate metabolism_Homo sapiens_hsa006200.35130792
121Malaria_Homo sapiens_hsa051440.33462835
122Purine metabolism_Homo sapiens_hsa002300.32872055
123Gastric acid secretion_Homo sapiens_hsa049710.31797592
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31404423
125ABC transporters_Homo sapiens_hsa020100.31389155
126Tuberculosis_Homo sapiens_hsa051520.31286332
127Ovarian steroidogenesis_Homo sapiens_hsa049130.30626443
128Fatty acid degradation_Homo sapiens_hsa000710.30158362
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29740520
130Chemical carcinogenesis_Homo sapiens_hsa052040.28798615
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25491937
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23994239
133Oxytocin signaling pathway_Homo sapiens_hsa049210.23669264
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20945924
135Systemic lupus erythematosus_Homo sapiens_hsa053220.20445995
136Chemokine signaling pathway_Homo sapiens_hsa040620.19505098
137Olfactory transduction_Homo sapiens_hsa047400.19012051
138Shigellosis_Homo sapiens_hsa051310.18602448
139Choline metabolism in cancer_Homo sapiens_hsa052310.17697703
140RNA polymerase_Homo sapiens_hsa030200.17504830
141ErbB signaling pathway_Homo sapiens_hsa040120.15685006
142cAMP signaling pathway_Homo sapiens_hsa040240.15347131
143Mineral absorption_Homo sapiens_hsa049780.15259005
144MAPK signaling pathway_Homo sapiens_hsa040100.14403320
145Prion diseases_Homo sapiens_hsa050200.13161575
146Tight junction_Homo sapiens_hsa045300.13132481

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