SNURF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within the Prader-Willi Syndrome critical region on chromosome 15. Transcripts produced from this gene initiate at an imprinting center and are paternally-imprinted. These transcripts may be bicistronic and also encode SNRPN (small nuclear ribonucleoprotein polypeptide N) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. Extensive alternative splicing and promoter usage occurs in this region and the full-length nature of some of these transcripts has not been determined. Alterations in the imprinting center are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.74808553
2ATP synthesis coupled proton transport (GO:0015986)7.29855781
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.29855781
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.34587863
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.30428026
6synaptic vesicle maturation (GO:0016188)6.03315697
7establishment of protein localization to mitochondrial membrane (GO:0090151)6.02002627
8respiratory electron transport chain (GO:0022904)6.01488603
9sequestering of actin monomers (GO:0042989)5.99085604
10electron transport chain (GO:0022900)5.89043079
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.66436071
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56388232
13viral transcription (GO:0019083)5.46993706
14chaperone-mediated protein transport (GO:0072321)5.39625312
15protein neddylation (GO:0045116)5.35389934
16vocalization behavior (GO:0071625)5.34290407
17translational termination (GO:0006415)5.32969471
18synaptic vesicle exocytosis (GO:0016079)5.29847870
19locomotory exploration behavior (GO:0035641)5.21029920
20regulation of synaptic vesicle exocytosis (GO:2000300)5.19173124
21glutamate secretion (GO:0014047)5.05096182
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.04946878
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.95952676
24regulation of synaptic vesicle transport (GO:1902803)4.81035988
25protein complex biogenesis (GO:0070271)4.76957829
26cotranslational protein targeting to membrane (GO:0006613)4.75751431
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.75246511
28response to pheromone (GO:0019236)4.68631324
29regulation of glutamate receptor signaling pathway (GO:1900449)4.68075454
30protein targeting to ER (GO:0045047)4.67220706
31ribosomal small subunit assembly (GO:0000028)4.66104898
32ionotropic glutamate receptor signaling pathway (GO:0035235)4.59957718
33neuronal action potential propagation (GO:0019227)4.57733124
34neurotransmitter secretion (GO:0007269)4.52252269
35mitochondrial respiratory chain complex assembly (GO:0033108)4.49381508
36establishment of protein localization to endoplasmic reticulum (GO:0072599)4.48871817
37regulation of neuronal synaptic plasticity (GO:0048168)4.44786223
38protein localization to synapse (GO:0035418)4.44330652
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.39576583
40mitochondrial respiratory chain complex I assembly (GO:0032981)4.39576583
41NADH dehydrogenase complex assembly (GO:0010257)4.39576583
42translational elongation (GO:0006414)4.33498977
43synaptic vesicle endocytosis (GO:0048488)4.32501093
44protein localization to endoplasmic reticulum (GO:0070972)4.31477211
45synaptic transmission, glutamatergic (GO:0035249)4.31279408
46neuron cell-cell adhesion (GO:0007158)4.30788701
47gamma-aminobutyric acid transport (GO:0015812)4.29974689
48regulation of long-term neuronal synaptic plasticity (GO:0048169)4.21281498
49neurotransmitter-gated ion channel clustering (GO:0072578)4.19949555
50layer formation in cerebral cortex (GO:0021819)4.18304716
51positive regulation of synapse maturation (GO:0090129)4.13774179
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13440050
53transcription elongation from RNA polymerase III promoter (GO:0006385)4.12325656
54termination of RNA polymerase III transcription (GO:0006386)4.12325656
55neuron-neuron synaptic transmission (GO:0007270)4.07414505
56cellular protein complex disassembly (GO:0043624)4.07240788
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07217862
58glutamate receptor signaling pathway (GO:0007215)4.06409057
59exploration behavior (GO:0035640)4.03127072
60proteasome assembly (GO:0043248)4.00824809
61inner mitochondrial membrane organization (GO:0007007)4.00310795
62long-term memory (GO:0007616)3.91755571
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91663979
64hydrogen ion transmembrane transport (GO:1902600)3.90650707
65ATP biosynthetic process (GO:0006754)3.86829215
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86706436
67viral life cycle (GO:0019058)3.85912545
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.84534305
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.80937474
70translational initiation (GO:0006413)3.79630029
71cellular potassium ion homeostasis (GO:0030007)3.78291113
72dendritic spine morphogenesis (GO:0060997)3.76927049
73positive regulation of membrane potential (GO:0045838)3.75771731
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.75619862
75DNA damage response, detection of DNA damage (GO:0042769)3.72713384
76regulation of synapse structural plasticity (GO:0051823)3.71962074
77neurotransmitter transport (GO:0006836)3.66520616
78regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62137198
79transmission of nerve impulse (GO:0019226)3.60798825
80regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.59061860
81cell communication by electrical coupling (GO:0010644)3.58756619
82regulation of neurotransmitter secretion (GO:0046928)3.55315848
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52232096
84chromatin remodeling at centromere (GO:0031055)3.51481993
85cell migration in hindbrain (GO:0021535)3.50918030
86ribosomal small subunit biogenesis (GO:0042274)3.50905001
87regulation of postsynaptic membrane potential (GO:0060078)3.48733562
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48168152
89positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47898555
90membrane hyperpolarization (GO:0060081)3.46845093
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.46457018
92maturation of SSU-rRNA (GO:0030490)3.46235360
93proton transport (GO:0015992)3.46183258
94CENP-A containing nucleosome assembly (GO:0034080)3.45816711
95regulation of synaptic transmission, glutamatergic (GO:0051966)3.45669335
96neuromuscular process controlling posture (GO:0050884)3.45158548
97presynaptic membrane assembly (GO:0097105)3.45117310
98sodium ion export (GO:0071436)3.44902670
99regulation of mitochondrial translation (GO:0070129)3.44557395
100purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.44096333
101regulation of synapse maturation (GO:0090128)3.43349323
102gamma-aminobutyric acid signaling pathway (GO:0007214)3.42636356
103protein complex disassembly (GO:0043241)3.41615035
104regulation of synaptic plasticity (GO:0048167)3.41411379
105purine nucleoside triphosphate biosynthetic process (GO:0009145)3.40934468
106hydrogen transport (GO:0006818)3.39797295
107neuron recognition (GO:0008038)3.39551567
108translation (GO:0006412)3.39027135
109establishment of integrated proviral latency (GO:0075713)3.38426251
110long-term synaptic potentiation (GO:0060291)3.35601992
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34655753
112otic vesicle formation (GO:0030916)3.34251455
113regulation of neurotransmitter transport (GO:0051588)3.34078441
114proline transport (GO:0015824)3.33986864
115membrane depolarization during action potential (GO:0086010)3.33117257
116activation of protein kinase A activity (GO:0034199)3.32404091
117regulation of neurotransmitter levels (GO:0001505)3.32118972
118spliceosomal complex assembly (GO:0000245)3.31614797
119cerebellar Purkinje cell differentiation (GO:0021702)3.31191099
120regulation of helicase activity (GO:0051095)3.30155892
121regulation of dendritic spine morphogenesis (GO:0061001)3.29669049
122respiratory chain complex IV assembly (GO:0008535)3.29478996
123glycine transport (GO:0015816)3.26769111
124protein-cofactor linkage (GO:0018065)3.26252652
125prepulse inhibition (GO:0060134)3.25807080
126behavioral response to nicotine (GO:0035095)3.25479459
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.25330759
128spliceosomal snRNP assembly (GO:0000387)3.25026739
129macromolecular complex disassembly (GO:0032984)3.24770549
130cerebellar granule cell differentiation (GO:0021707)3.23630879
131postsynaptic membrane organization (GO:0001941)3.18434553
132cytochrome complex assembly (GO:0017004)3.18419318
133dendrite morphogenesis (GO:0048813)3.17202104
134neuromuscular process controlling balance (GO:0050885)3.17037602
135response to auditory stimulus (GO:0010996)3.16623570
136innervation (GO:0060384)3.16618976
137behavioral defense response (GO:0002209)3.15019508
138behavioral fear response (GO:0001662)3.15019508
139regulation of mitotic spindle checkpoint (GO:1903504)3.14630430
140regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14630430
141negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13859758
142L-amino acid import (GO:0043092)3.10843303
143positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10064182
144membrane depolarization (GO:0051899)3.09960278
145central nervous system projection neuron axonogenesis (GO:0021952)3.09685419
146positive regulation of dendritic spine morphogenesis (GO:0061003)3.08839051
147neuronal ion channel clustering (GO:0045161)3.06578855
148regulation of glutamate secretion (GO:0014048)3.06425095
149auditory behavior (GO:0031223)3.06100767
150protein targeting to membrane (GO:0006612)3.03823378
151regulation of synaptic transmission, GABAergic (GO:0032228)3.03726922
152nuclear-transcribed mRNA catabolic process (GO:0000956)3.03169409
153intracellular protein transmembrane import (GO:0044743)3.03154707
154establishment of synaptic vesicle localization (GO:0097480)3.02818481
155synaptic vesicle transport (GO:0048489)3.02818481
156positive regulation of dendritic spine development (GO:0060999)3.02655278
157learning (GO:0007612)3.02542299
158striatum development (GO:0021756)3.02353830
159ribonucleoside triphosphate biosynthetic process (GO:0009201)3.00678010
160synaptic transmission (GO:0007268)2.99659362
161regulation of synaptic transmission (GO:0050804)2.97972425
162regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97803005
163presynaptic membrane organization (GO:0097090)2.97243110
164dopamine receptor signaling pathway (GO:0007212)2.96325136
165positive regulation of potassium ion transmembrane transport (GO:1901381)2.95683714
166synapse assembly (GO:0007416)2.94989177
167neuromuscular synaptic transmission (GO:0007274)2.94775635
168histone exchange (GO:0043486)2.90663952
169mRNA catabolic process (GO:0006402)2.87609180
170establishment of protein localization to mitochondrion (GO:0072655)2.86497284
171water-soluble vitamin biosynthetic process (GO:0042364)2.85198721
172ribosomal large subunit biogenesis (GO:0042273)2.83700824
173negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83041306
174negative regulation of ligase activity (GO:0051352)2.83041306
175regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82495721
176regulation of posttranscriptional gene silencing (GO:0060147)2.79235387
177regulation of gene silencing by miRNA (GO:0060964)2.79235387
178regulation of gene silencing by RNA (GO:0060966)2.79235387
179rRNA modification (GO:0000154)2.78221006
180protein localization to mitochondrion (GO:0070585)2.77797766
181protein targeting to mitochondrion (GO:0006626)2.76982499
182neuron fate determination (GO:0048664)2.72894701
183thalamus development (GO:0021794)2.72778546
184positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71419830
185histone mRNA metabolic process (GO:0008334)2.69930581
186nucleoside triphosphate biosynthetic process (GO:0009142)2.63512673
187tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62364171
188RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62364171
1897-methylguanosine mRNA capping (GO:0006370)2.61015049
190mitochondrial transport (GO:0006839)2.60719932
191DNA replication-independent nucleosome organization (GO:0034724)2.60480302
192DNA replication-independent nucleosome assembly (GO:0006336)2.60480302
193RNA catabolic process (GO:0006401)2.59426032
194pseudouridine synthesis (GO:0001522)2.57473957
195purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.57458982
196purine nucleoside monophosphate biosynthetic process (GO:0009127)2.57458982
197RNA capping (GO:0036260)2.55375045
1987-methylguanosine RNA capping (GO:0009452)2.55375045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.31275274
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.15913870
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.85241600
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75575532
5GBX2_23144817_ChIP-Seq_PC3_Human3.59785999
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.59434832
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98685339
8REST_21632747_ChIP-Seq_MESCs_Mouse2.89736499
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87819817
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.82859052
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78802977
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77589225
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.70234054
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66375142
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66375142
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66066568
17DROSHA_22980978_ChIP-Seq_HELA_Human2.55036116
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49581585
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.49465409
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45898499
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44993793
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.41568358
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40343742
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38282081
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36260109
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36251189
27ELK1_19687146_ChIP-ChIP_HELA_Human2.35726846
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28284030
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27218905
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.26395152
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25267506
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23603199
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.20351877
34MYC_18555785_ChIP-Seq_MESCs_Mouse2.19858139
35SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18057018
36ETS1_20019798_ChIP-Seq_JURKAT_Human2.16462310
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16120697
38POU5F1_16153702_ChIP-ChIP_HESCs_Human2.15175969
39EED_16625203_ChIP-ChIP_MESCs_Mouse2.14287809
40FUS_26573619_Chip-Seq_HEK293_Human2.14181217
41EWS_26573619_Chip-Seq_HEK293_Human2.09698320
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09432893
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02957149
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90092888
45MYC_18940864_ChIP-ChIP_HL60_Human1.89664635
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89622283
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85600947
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.85443365
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82386219
50VDR_22108803_ChIP-Seq_LS180_Human1.80665519
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79168282
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74959863
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.68095091
54AR_21572438_ChIP-Seq_LNCaP_Human1.67961830
55VDR_23849224_ChIP-Seq_CD4+_Human1.67477334
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59236885
57SMAD4_21799915_ChIP-Seq_A2780_Human1.57714548
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56338418
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.56157578
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56082863
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55544817
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55368434
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.53490058
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49190231
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46649428
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46585247
67TTF2_22483619_ChIP-Seq_HELA_Human1.45966162
68FOXP3_21729870_ChIP-Seq_TREG_Human1.45609956
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45427974
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44378478
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43158763
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39099151
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38808329
74* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32927377
75TAF15_26573619_Chip-Seq_HEK293_Human1.32514320
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.31091441
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30745557
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30166887
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.29213583
80* YY1_21170310_ChIP-Seq_MESCs_Mouse1.29128191
81STAT3_23295773_ChIP-Seq_U87_Human1.29115403
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28694336
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.28500534
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.28306220
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27183106
86AR_19668381_ChIP-Seq_PC3_Human1.26324281
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26264384
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25873146
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24377663
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.23932830
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23713873
92P300_19829295_ChIP-Seq_ESCs_Human1.22651194
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22131476
94ZNF274_21170338_ChIP-Seq_K562_Hela1.20700692
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19332142
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19037028
97AR_25329375_ChIP-Seq_VCAP_Human1.18982216
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18625109
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18240884
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17934821
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17460951
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15376109
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14954816
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.14885758
105* RNF2_27304074_Chip-Seq_NSC_Mouse1.14475507
106ELK1_22589737_ChIP-Seq_MCF10A_Human1.14248274
107XRN2_22483619_ChIP-Seq_HELA_Human1.13941169
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13601041
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13601041
110DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12906887
111* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12788034
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12621447
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12361871
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.12030692
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11800883
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09768489
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09601241
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08367116
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07395125
120KDM2B_26808549_Chip-Seq_K562_Human1.07225849
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.06455912
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06236428
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06236428
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06236428
125TCF4_23295773_ChIP-Seq_U87_Human1.06192863
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05890086
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04348192
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03941550
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03935170
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03541835
131* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03131448
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03083575
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01318418
134NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00727302
135SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00616793
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99673728
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.99312567
138NFE2_27457419_Chip-Seq_LIVER_Mouse0.98991684
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98736845
140HTT_18923047_ChIP-ChIP_STHdh_Human0.97978261
141E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97689202
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97183286
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.97117436
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96457894
145GATA1_26923725_Chip-Seq_HPCs_Mouse0.95216087
146WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94691432
147TP53_22573176_ChIP-Seq_HFKS_Human0.94497139
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.94066880
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.93564890
150ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93490163
151* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92987664
152* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92906565
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92116953
154SOX2_19829295_ChIP-Seq_ESCs_Human0.92071515
155NANOG_19829295_ChIP-Seq_ESCs_Human0.92071515
156UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91152703
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90946872
158RUNX2_22187159_ChIP-Seq_PCA_Human0.90343550
159AHR_22903824_ChIP-Seq_MCF-7_Human0.90307958
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90231375
161* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90005310
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89424446
163POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88992334
164* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88761485
165SOX9_26525672_Chip-Seq_HEART_Mouse0.88743095
166TET1_21490601_ChIP-Seq_MESCs_Mouse0.88702873
167SALL1_21062744_ChIP-ChIP_HESCs_Human0.88420063
168BCAT_22108803_ChIP-Seq_LS180_Human0.87357574
169CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87353230
170EZH2_27294783_Chip-Seq_NPCs_Mouse0.87209132
171ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86976753
172CTCF_27219007_Chip-Seq_Bcells_Human0.86711279
173SMAD3_21741376_ChIP-Seq_ESCs_Human0.86453065
174IGF1R_20145208_ChIP-Seq_DFB_Human0.86147967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.25478249
2MP0009379_abnormal_foot_pigmentation4.57332761
3MP0003880_abnormal_central_pattern4.32248962
4MP0003635_abnormal_synaptic_transmissio3.92742069
5MP0003136_yellow_coat_color3.43742362
6MP0004270_analgesia3.32952000
7MP0009745_abnormal_behavioral_response3.20611337
8MP0002063_abnormal_learning/memory/cond3.15618999
9MP0009046_muscle_twitch3.13458743
10MP0002064_seizures2.96818322
11MP0002822_catalepsy2.86569335
12MP0005423_abnormal_somatic_nervous2.64966057
13MP0002572_abnormal_emotion/affect_behav2.62204443
14MP0002735_abnormal_chemical_nociception2.61730811
15MP0001968_abnormal_touch/_nociception2.61437568
16MP0002734_abnormal_mechanical_nocicepti2.51622194
17MP0001486_abnormal_startle_reflex2.51392974
18MP0002272_abnormal_nervous_system2.49589846
19MP0000566_synostosis2.27288119
20MP0001984_abnormal_olfaction2.25277027
21MP0003011_delayed_dark_adaptation2.13733102
22MP0002184_abnormal_innervation2.13212244
23MP0002938_white_spotting2.12969961
24MP0000778_abnormal_nervous_system2.12272545
25MP0003941_abnormal_skin_development2.09577593
26MP0008569_lethality_at_weaning2.09373691
27MP0004858_abnormal_nervous_system2.04989527
28MP0002736_abnormal_nociception_after2.03341484
29MP0003787_abnormal_imprinting1.96318914
30MP0002277_abnormal_respiratory_mucosa1.94615771
31MP0005646_abnormal_pituitary_gland1.94391664
32MP0004133_heterotaxia1.92454686
33MP0004811_abnormal_neuron_physiology1.91728944
34MP0002067_abnormal_sensory_capabilities1.90527571
35MP0001970_abnormal_pain_threshold1.85532210
36MP0001501_abnormal_sleep_pattern1.84604702
37MP0001293_anophthalmia1.81884932
38MP0002557_abnormal_social/conspecific_i1.80182739
39MP0002733_abnormal_thermal_nociception1.79974521
40MP0006276_abnormal_autonomic_nervous1.77959360
41MP0001440_abnormal_grooming_behavior1.72194198
42MP0008877_abnormal_DNA_methylation1.71257139
43MP0000955_abnormal_spinal_cord1.69482550
44MP0008058_abnormal_DNA_repair1.69325294
45MP0005084_abnormal_gallbladder_morpholo1.67956106
46MP0005394_taste/olfaction_phenotype1.67386925
47MP0005499_abnormal_olfactory_system1.67386925
48MP0004924_abnormal_behavior1.65662213
49MP0005386_behavior/neurological_phenoty1.65662213
50MP0003890_abnormal_embryonic-extraembry1.63679119
51MP0010030_abnormal_orbit_morphology1.62160654
52MP0003122_maternal_imprinting1.52342211
53MP0010386_abnormal_urinary_bladder1.50342001
54MP0001188_hyperpigmentation1.49632793
55MP0002882_abnormal_neuron_morphology1.49076616
56MP0002909_abnormal_adrenal_gland1.47817462
57MP0001502_abnormal_circadian_rhythm1.46498576
58MP0005645_abnormal_hypothalamus_physiol1.44359489
59MP0004885_abnormal_endolymph1.42324861
60MP0002837_dystrophic_cardiac_calcinosis1.41645630
61MP0002066_abnormal_motor_capabilities/c1.39956758
62MP0003718_maternal_effect1.35658412
63MP0003938_abnormal_ear_development1.32734862
64MP0003329_amyloid_beta_deposits1.29162337
65MP0002653_abnormal_ependyma_morphology1.27965212
66MP0002152_abnormal_brain_morphology1.25099715
67MP0001529_abnormal_vocalization1.23519414
68MP0008995_early_reproductive_senescence1.23168822
69MP0009780_abnormal_chondrocyte_physiolo1.21996462
70MP0002638_abnormal_pupillary_reflex1.21474954
71MP0003879_abnormal_hair_cell1.21397812
72MP0006292_abnormal_olfactory_placode1.21014050
73MP0003937_abnormal_limbs/digits/tail_de1.19116157
74MP0003633_abnormal_nervous_system1.15999956
75MP0001905_abnormal_dopamine_level1.15804098
76MP0003119_abnormal_digestive_system1.15615009
77MP0002697_abnormal_eye_size1.14888901
78MP0000049_abnormal_middle_ear1.14329191
79MP0004142_abnormal_muscle_tone1.13707776
80MP0001177_atelectasis1.12054158
81MP0001286_abnormal_eye_development1.11514695
82MP0003631_nervous_system_phenotype1.07266637
83MP0003567_abnormal_fetal_cardiomyocyte1.07251173
84MP0004957_abnormal_blastocyst_morpholog1.05917991
85MP0000372_irregular_coat_pigmentation1.05303361
86MP0003186_abnormal_redox_activity1.04435514
87MP0002069_abnormal_eating/drinking_beha1.04301281
88MP0004145_abnormal_muscle_electrophysio1.03991963
89MP0005551_abnormal_eye_electrophysiolog1.02598985
90MP0005187_abnormal_penis_morphology1.00259638
91MP0002229_neurodegeneration0.99907041
92MP0003693_abnormal_embryo_hatching0.99782054
93MP0008789_abnormal_olfactory_epithelium0.99498906
94MP0000631_abnormal_neuroendocrine_gland0.96435218
95MP0000569_abnormal_digit_pigmentation0.94691575
96MP0000579_abnormal_nail_morphology0.93895026
97MP0002752_abnormal_somatic_nervous0.92904431
98MP0003121_genomic_imprinting0.90131685
99MP0003632_abnormal_nervous_system0.88786336
100MP0005195_abnormal_posterior_eye0.88431117
101MP0002233_abnormal_nose_morphology0.87802709
102MP0003195_calcinosis0.85695135
103MP0003861_abnormal_nervous_system0.84846924
104MP0004085_abnormal_heartbeat0.83162697
105MP0003634_abnormal_glial_cell0.81404151
106MP0005391_vision/eye_phenotype0.81354583
107MP0006035_abnormal_mitochondrial_morpho0.79932577
108MP0001963_abnormal_hearing_physiology0.79892248
109MP0008872_abnormal_physiological_respon0.79778374
110MP0003283_abnormal_digestive_organ0.78197835
111MP0002282_abnormal_trachea_morphology0.77865213
112MP0001299_abnormal_eye_distance/0.76893879
113MP0000537_abnormal_urethra_morphology0.75319302
114MP0003315_abnormal_perineum_morphology0.72517209
115MP0004742_abnormal_vestibular_system0.72397059
116MP0000534_abnormal_ureter_morphology0.72392490
117MP0003137_abnormal_impulse_conducting0.72193437
118MP0001485_abnormal_pinna_reflex0.69780279
119MP0004215_abnormal_myocardial_fiber0.68908960
120MP0000751_myopathy0.67197295
121MP0006072_abnormal_retinal_apoptosis0.66991699
122MP0000013_abnormal_adipose_tissue0.65503597
123MP0010769_abnormal_survival0.64988496
124MP0003123_paternal_imprinting0.64906702
125MP0002751_abnormal_autonomic_nervous0.64864947
126MP0002082_postnatal_lethality0.64233305
127MP0010770_preweaning_lethality0.64233305
128MP0005535_abnormal_body_temperature0.63610302
129MP0010768_mortality/aging0.61479193
130MP0002234_abnormal_pharynx_morphology0.60532475
131MP0001943_abnormal_respiration0.58649352
132MP0002102_abnormal_ear_morphology0.57823634
133MP0004233_abnormal_muscle_weight0.57450390
134MP0008874_decreased_physiological_sensi0.56802781
135MP0000026_abnormal_inner_ear0.56195342
136MP0002090_abnormal_vision0.55237265
137MP0005253_abnormal_eye_physiology0.54602912
138MP0003690_abnormal_glial_cell0.54373147

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.58099939
2Myokymia (HP:0002411)6.16466707
3Increased hepatocellular lipid droplets (HP:0006565)5.12487467
4Acute necrotizing encephalopathy (HP:0006965)5.09445537
5Focal seizures (HP:0007359)5.08923648
6Mitochondrial inheritance (HP:0001427)4.53677653
7Febrile seizures (HP:0002373)4.49200959
8Lipid accumulation in hepatocytes (HP:0006561)4.49107535
9Epileptic encephalopathy (HP:0200134)4.36882403
10Abnormal mitochondria in muscle tissue (HP:0008316)4.34262065
11Progressive macrocephaly (HP:0004481)4.33710464
12Septo-optic dysplasia (HP:0100842)4.32004187
13Acute encephalopathy (HP:0006846)4.30764284
14Visual hallucinations (HP:0002367)4.18700215
15Abnormal number of erythroid precursors (HP:0012131)4.13428425
16Progressive cerebellar ataxia (HP:0002073)4.08228479
17Atonic seizures (HP:0010819)4.03961828
18Renal Fanconi syndrome (HP:0001994)3.99982470
19Action tremor (HP:0002345)3.81848343
20Abnormality of cells of the erythroid lineage (HP:0012130)3.79526744
21Increased CSF lactate (HP:0002490)3.77839940
22Absence seizures (HP:0002121)3.74193369
23Congenital, generalized hypertrichosis (HP:0004540)3.68722127
24Hepatocellular necrosis (HP:0001404)3.51526086
25Dialeptic seizures (HP:0011146)3.42324799
26Abnormality of the labia minora (HP:0012880)3.39947954
27Macrocytic anemia (HP:0001972)3.36518808
28Ankle clonus (HP:0011448)3.28832403
29Generalized tonic-clonic seizures (HP:0002069)3.28346233
30Depression (HP:0000716)3.26792322
31Poor eye contact (HP:0000817)3.26559524
32Hepatic necrosis (HP:0002605)3.24598852
33Exertional dyspnea (HP:0002875)3.23616326
34Hyperventilation (HP:0002883)3.14358901
35Impaired vibration sensation in the lower limbs (HP:0002166)3.12758813
36Gaze-evoked nystagmus (HP:0000640)3.11030949
37Cerebral edema (HP:0002181)3.09452760
38Reticulocytopenia (HP:0001896)3.08413488
39Supranuclear gaze palsy (HP:0000605)3.05043541
40Oral leukoplakia (HP:0002745)3.04309143
413-Methylglutaconic aciduria (HP:0003535)3.02772194
42Increased intramyocellular lipid droplets (HP:0012240)3.02089008
43Abnormal eating behavior (HP:0100738)3.01672933
44Dysdiadochokinesis (HP:0002075)2.97922563
45Absent septum pellucidum (HP:0001331)2.97800441
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96693138
47Amblyopia (HP:0000646)2.90525891
48Impaired social interactions (HP:0000735)2.88592239
49Abnormal social behavior (HP:0012433)2.88592239
50Colon cancer (HP:0003003)2.88085170
51Abnormality of the lower motor neuron (HP:0002366)2.87791807
52Methylmalonic acidemia (HP:0002912)2.79033035
53Ventricular fibrillation (HP:0001663)2.75409713
54Broad-based gait (HP:0002136)2.72552396
55Postural instability (HP:0002172)2.72102834
56Dysmetria (HP:0001310)2.66534736
57Pancreatic fibrosis (HP:0100732)2.65789971
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63193651
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63193651
60Urinary bladder sphincter dysfunction (HP:0002839)2.62172106
61Maternal diabetes (HP:0009800)2.59919713
62Truncal ataxia (HP:0002078)2.59830976
63Anxiety (HP:0000739)2.59749700
64Agitation (HP:0000713)2.59396612
65Leukodystrophy (HP:0002415)2.57607899
66Pancreatic cysts (HP:0001737)2.56877485
67Optic nerve hypoplasia (HP:0000609)2.56359290
68Megalencephaly (HP:0001355)2.53780215
69True hermaphroditism (HP:0010459)2.52972577
70Abnormality of renal resorption (HP:0011038)2.52815450
71Abnormality of the septum pellucidum (HP:0007375)2.52673974
72Respiratory difficulties (HP:0002880)2.51734531
73Urinary urgency (HP:0000012)2.48790173
74Optic disc pallor (HP:0000543)2.46834079
75Spastic gait (HP:0002064)2.46603074
76Fetal akinesia sequence (HP:0001989)2.45674485
77Hemiparesis (HP:0001269)2.44808023
78Aplastic anemia (HP:0001915)2.41360608
79Abnormality of the corticospinal tract (HP:0002492)2.40002786
80Impaired smooth pursuit (HP:0007772)2.37464710
81Thickened helices (HP:0000391)2.35171051
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34688191
83Progressive inability to walk (HP:0002505)2.31110403
84EEG with generalized epileptiform discharges (HP:0011198)2.30510138
85Epileptiform EEG discharges (HP:0011182)2.29956491
86Increased muscle lipid content (HP:0009058)2.29893007
87Genetic anticipation (HP:0003743)2.28672375
88Bradykinesia (HP:0002067)2.28488796
89Bilateral microphthalmos (HP:0007633)2.27063581
90Insidious onset (HP:0003587)2.26735876
91Termporal pattern (HP:0011008)2.26735876
92Glycosuria (HP:0003076)2.26722175
93Abnormality of urine glucose concentration (HP:0011016)2.26722175
94Intention tremor (HP:0002080)2.26037378
95Stereotypic behavior (HP:0000733)2.24718051
96Abnormality of ocular smooth pursuit (HP:0000617)2.22728034
97Respiratory failure (HP:0002878)2.21221123
98Pallor (HP:0000980)2.20922305
99Hemiplegia (HP:0002301)2.20783905
100Annular pancreas (HP:0001734)2.19930986
101Hyperphosphaturia (HP:0003109)2.19393827
102Focal dystonia (HP:0004373)2.18611466
103Lower limb muscle weakness (HP:0007340)2.17765729
104Esophageal atresia (HP:0002032)2.17488416
105Scanning speech (HP:0002168)2.17219046
106Pheochromocytoma (HP:0002666)2.17186338
107Hypsarrhythmia (HP:0002521)2.15404444
108Partial duplication of thumb phalanx (HP:0009944)2.15223771
109Drooling (HP:0002307)2.14799390
110Excessive salivation (HP:0003781)2.14799390
111Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13257137
112Lactic acidosis (HP:0003128)2.11984112
113Torticollis (HP:0000473)2.09785566
114Tetraplegia (HP:0002445)2.09458741
115Polyphagia (HP:0002591)2.08893482
116Methylmalonic aciduria (HP:0012120)2.08254248
117Nephronophthisis (HP:0000090)2.07768686
118Central scotoma (HP:0000603)2.07642084
119Intestinal atresia (HP:0011100)2.07402197
120Hypoplasia of the pons (HP:0012110)2.07322938
121Absent speech (HP:0001344)2.06914786
122Abnormality of midbrain morphology (HP:0002418)2.06093597
123Molar tooth sign on MRI (HP:0002419)2.06093597
124Exercise intolerance (HP:0003546)2.03243684
125Hypothermia (HP:0002045)2.01784606
126Pointed chin (HP:0000307)2.01614401
127Aplasia involving bones of the extremities (HP:0009825)2.01584952
128Aplasia involving bones of the upper limbs (HP:0009823)2.01584952
129Aplasia of the phalanges of the hand (HP:0009802)2.01584952
130Hypoglycemic coma (HP:0001325)2.00275687
131Mutism (HP:0002300)2.00207671
132Insomnia (HP:0100785)1.99674140
133Impaired vibratory sensation (HP:0002495)1.99619045
134Abnormality of the pons (HP:0007361)1.99584139
135Gastrointestinal atresia (HP:0002589)1.99328810
136Partial duplication of the phalanx of hand (HP:0009999)1.98683770
137Incomplete penetrance (HP:0003829)1.98220757
138Increased serum lactate (HP:0002151)1.97802357
139Status epilepticus (HP:0002133)1.96060421
140Gait ataxia (HP:0002066)1.94913599
141Dysmetric saccades (HP:0000641)1.94756851
142Generalized aminoaciduria (HP:0002909)1.91991714
143Supernumerary spleens (HP:0009799)1.91289841
144Pendular nystagmus (HP:0012043)1.90815267
145Homocystinuria (HP:0002156)1.89549210
146Abnormality of homocysteine metabolism (HP:0010919)1.89549210
147Limb dystonia (HP:0002451)1.89409328
148Horizontal nystagmus (HP:0000666)1.89396371
149Poor suck (HP:0002033)1.89388869
150Failure to thrive in infancy (HP:0001531)1.87123820
151Growth hormone deficiency (HP:0000824)1.84043794
152Specific learning disability (HP:0001328)1.83725126
153Clonus (HP:0002169)1.83680320
154Sclerocornea (HP:0000647)1.82975211
155Anencephaly (HP:0002323)1.81580277
156Shoulder girdle muscle weakness (HP:0003547)1.81232202
157Medial flaring of the eyebrow (HP:0010747)1.80364867
158Protruding tongue (HP:0010808)1.80241009
159Anophthalmia (HP:0000528)1.79257993
160Lethargy (HP:0001254)1.78539546
161X-linked dominant inheritance (HP:0001423)1.77907164
162Rib fusion (HP:0000902)1.77267434
163Megaloblastic anemia (HP:0001889)1.77200201
164Papilledema (HP:0001085)1.77180769
165Craniofacial dystonia (HP:0012179)1.76961839
166Abnormality of methionine metabolism (HP:0010901)1.76788535
167Bundle branch block (HP:0011710)1.74761501
168Sleep apnea (HP:0010535)1.73919280
169Neuroendocrine neoplasm (HP:0100634)1.73561172
170Generalized myoclonic seizures (HP:0002123)1.72936625
171Spinal canal stenosis (HP:0003416)1.72860921
172Abnormality of binocular vision (HP:0011514)1.71767278
173Diplopia (HP:0000651)1.71767278
174Hyperinsulinemic hypoglycemia (HP:0000825)1.70595257
175Abnormal EKG (HP:0003115)1.70453076
176Lissencephaly (HP:0001339)1.70334654
177Hypogonadotrophic hypogonadism (HP:0000044)1.70161050
178Hyperglycinemia (HP:0002154)1.69723333
179Gastroesophageal reflux (HP:0002020)1.69677775
180Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69006413
181Inability to walk (HP:0002540)1.68872230
182Abnormality of the lacrimal duct (HP:0011481)1.68367596
183Hypoglycemic seizures (HP:0002173)1.65195420
184Cellular immunodeficiency (HP:0005374)1.63755220
185Abnormality of vitamin B metabolism (HP:0004340)1.63294973
186Neoplasm of the heart (HP:0100544)1.62151765
187Vaginal atresia (HP:0000148)1.61955135
188Dysphonia (HP:0001618)1.60875077
189Genital tract atresia (HP:0001827)1.60572728
190Abnormality of aspartate family amino acid metabolism (HP:0010899)1.60320981
191Triphalangeal thumb (HP:0001199)1.59906801
192Gait imbalance (HP:0002141)1.59891221
193Abnormality of the nasolacrimal system (HP:0000614)1.59104213
194Male pseudohermaphroditism (HP:0000037)1.58734726
195Abnormal lung lobation (HP:0002101)1.58346239
196Amniotic constriction ring (HP:0009775)1.57899880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.71100652
2NTRK33.78992579
3MAP3K43.40267580
4MARK13.31030237
5MAP3K93.20024720
6EPHA43.18575584
7VRK12.99997105
8PRPF4B2.98091766
9MINK12.78160393
10ZAK2.76656510
11MAP2K72.76229840
12PRKD32.65470061
13CDC72.51890836
14PAK62.45925447
15TAF12.36279871
16BUB12.34191536
17NTRK22.15847098
18NME12.14468517
19STK162.01237084
20DAPK22.00075297
21PINK11.93635827
22CAMKK11.90657141
23TLK11.87723741
24MAP4K21.86310943
25KSR21.85117997
26SGK21.84484480
27AKT31.83280501
28KSR11.83229657
29SGK2231.82639404
30SGK4941.82639404
31STK381.79750971
32MAPK131.76473274
33NUAK11.73814357
34DYRK31.73106381
35MAP2K41.72361781
36PBK1.69696486
37MST41.69683125
38CASK1.64872178
39BMPR1B1.63374039
40WNK31.63286102
41SRPK11.61165371
42TSSK61.54277796
43CDK51.52059384
44SGK31.47535197
45MKNK21.47423273
46INSRR1.46307222
47ADRBK21.44546998
48SIK31.39139427
49PASK1.38391215
50PLK21.37991501
51FGFR21.33054690
52BRSK21.32742170
53MKNK11.31190003
54NTRK11.29609666
55NEK11.28949993
56MAPK151.25438501
57PNCK1.23813982
58ARAF1.22936461
59PRKCG1.17234845
60GRK51.15168053
61UHMK11.14866540
62TTK1.14518148
63TNIK1.12382874
64PRKCH1.10469035
65LATS21.10387817
66GRK11.04713762
67SIK21.04287313
68NLK1.03004298
69BRAF0.97915524
70TRIM280.97075935
71FRK0.97032080
72FES0.94039578
73MAP3K130.92263213
74ACVR1B0.91962009
75RIPK40.90135984
76DAPK10.90081207
77WEE10.89946661
78PHKG20.89050990
79PHKG10.89050990
80LMTK20.88630803
81EPHB20.86419437
82CDK180.86345613
83OXSR10.84453985
84MAP3K20.83786716
85CDK140.83635049
86CAMK10.81307281
87ALK0.79926167
88TIE10.78934783
89CDK150.78294154
90DYRK1A0.77371788
91MAP3K120.76862941
92NEK60.76336623
93BMPR20.76080521
94CSNK1G10.75974899
95TYRO30.75892587
96CAMK2A0.75207734
97TNK20.75025933
98PLK10.73824549
99MUSK0.73024473
100YES10.72500284
101CHEK20.72447784
102RPS6KA50.72285724
103BCR0.72179272
104FER0.68841664
105OBSCN0.68114073
106SGK10.67964915
107BRSK10.66521977
108CDK11A0.66489646
109ERBB30.66480670
110CDK190.65817878
111STK38L0.64161870
112PLK40.62686629
113WNK10.60848105
114CAMKK20.59659063
115STK110.59550527
116CDK30.59367111
117STK40.57855418
118BCKDK0.55611075
119PRKCZ0.55292199
120CAMK2B0.54910756
121PKN10.53982609
122MARK20.53811805
123CDC42BPA0.53320306
124CSNK2A20.52803499
125SCYL20.51875783
126RPS6KA30.51695909
127CSNK2A10.51432721
128RET0.50508158
129ROCK20.50216447
130PAK30.50147005
131MAPK100.49982994
132CSNK1E0.49480343
133ADRBK10.49397225
134RPS6KA20.48812489
135AURKB0.48373937
136STK240.47532127
137PLK30.47279234
138MAP2K10.47186743
139TGFBR10.47161647
140TAOK10.47150408
141MAP3K70.47110659
142DAPK30.45917317
143CAMK40.45872591
144RAF10.45539409
145PRKCE0.44825707
146CSNK1G30.44219223
147CAMK2G0.43560901
148CSNK1G20.42484502
149DYRK20.42101905
150MAPK80.41354545
151PRKACA0.41070879
152ROCK10.40360919
153TAOK20.38887054
154PTK2B0.38187753
155PRKG10.37502701
156CAMK2D0.37478353
157PRKCB0.34942382
158ATR0.34422923
159PDK10.34079396
160CSNK1A10.32820049
161DYRK1B0.31768382
162TXK0.30585098
163PRKACB0.30273875
164EIF2AK20.28877250
165CDK80.28487220

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.40675574
2Ribosome_Homo sapiens_hsa030104.88233802
3Parkinsons disease_Homo sapiens_hsa050124.65236155
4Nicotine addiction_Homo sapiens_hsa050333.84185997
5Synaptic vesicle cycle_Homo sapiens_hsa047213.59075711
6Proteasome_Homo sapiens_hsa030503.45170556
7Huntingtons disease_Homo sapiens_hsa050163.28790058
8Alzheimers disease_Homo sapiens_hsa050103.28217250
9RNA polymerase_Homo sapiens_hsa030203.10907558
10Olfactory transduction_Homo sapiens_hsa047403.08101381
11GABAergic synapse_Homo sapiens_hsa047273.02172223
12Protein export_Homo sapiens_hsa030602.85232809
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84740005
14Circadian entrainment_Homo sapiens_hsa047132.80700031
15Morphine addiction_Homo sapiens_hsa050322.74279861
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71861047
17Glutamatergic synapse_Homo sapiens_hsa047242.66736898
18Long-term potentiation_Homo sapiens_hsa047202.48325821
19Mismatch repair_Homo sapiens_hsa034302.26763441
20Dopaminergic synapse_Homo sapiens_hsa047282.23726080
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20697437
22Amphetamine addiction_Homo sapiens_hsa050312.19367570
23Insulin secretion_Homo sapiens_hsa049112.15940864
24Taste transduction_Homo sapiens_hsa047422.09244868
25Salivary secretion_Homo sapiens_hsa049702.01185291
26Spliceosome_Homo sapiens_hsa030402.00143939
27Cholinergic synapse_Homo sapiens_hsa047251.96536347
28Serotonergic synapse_Homo sapiens_hsa047261.88168120
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82625093
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81931630
31Homologous recombination_Homo sapiens_hsa034401.67723854
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66478648
33Gastric acid secretion_Homo sapiens_hsa049711.65454015
34Long-term depression_Homo sapiens_hsa047301.64534297
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61888380
36RNA degradation_Homo sapiens_hsa030181.59162240
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59105629
38Oxytocin signaling pathway_Homo sapiens_hsa049211.58987490
39Cocaine addiction_Homo sapiens_hsa050301.55733136
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51784372
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51714692
42Calcium signaling pathway_Homo sapiens_hsa040201.50609589
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.47694054
44DNA replication_Homo sapiens_hsa030301.45515988
45GnRH signaling pathway_Homo sapiens_hsa049121.45040056
46Gap junction_Homo sapiens_hsa045401.42981425
47Basal transcription factors_Homo sapiens_hsa030221.36536862
48Renin secretion_Homo sapiens_hsa049241.35871363
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29032241
50Type II diabetes mellitus_Homo sapiens_hsa049301.26641672
51Collecting duct acid secretion_Homo sapiens_hsa049661.24922316
52cAMP signaling pathway_Homo sapiens_hsa040241.20673087
53Axon guidance_Homo sapiens_hsa043601.18572874
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17772621
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10778028
56Estrogen signaling pathway_Homo sapiens_hsa049151.08603913
57ErbB signaling pathway_Homo sapiens_hsa040121.08131042
58Purine metabolism_Homo sapiens_hsa002301.06896012
59Melanogenesis_Homo sapiens_hsa049161.06656210
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05941079
61Nucleotide excision repair_Homo sapiens_hsa034201.02582399
62Glioma_Homo sapiens_hsa052141.02268329
63Pyrimidine metabolism_Homo sapiens_hsa002401.00846342
64Selenocompound metabolism_Homo sapiens_hsa004501.00785210
65Oocyte meiosis_Homo sapiens_hsa041140.99997817
66RNA transport_Homo sapiens_hsa030130.99629156
67Basal cell carcinoma_Homo sapiens_hsa052170.96595714
68One carbon pool by folate_Homo sapiens_hsa006700.96570058
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95257993
70Propanoate metabolism_Homo sapiens_hsa006400.94688043
71Butanoate metabolism_Homo sapiens_hsa006500.94512460
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93241085
73Folate biosynthesis_Homo sapiens_hsa007900.90524134
74Tryptophan metabolism_Homo sapiens_hsa003800.89683834
75Dorso-ventral axis formation_Homo sapiens_hsa043200.88187693
76Pyruvate metabolism_Homo sapiens_hsa006200.85976063
77Phototransduction_Homo sapiens_hsa047440.85693485
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.85360363
79Fanconi anemia pathway_Homo sapiens_hsa034600.84221845
80Vitamin digestion and absorption_Homo sapiens_hsa049770.82560725
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82346675
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.81336124
83Cardiac muscle contraction_Homo sapiens_hsa042600.80161664
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79544784
85Pancreatic secretion_Homo sapiens_hsa049720.77181063
86Choline metabolism in cancer_Homo sapiens_hsa052310.76603642
87Base excision repair_Homo sapiens_hsa034100.75941747
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75660198
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74398416
90Circadian rhythm_Homo sapiens_hsa047100.73775469
91Dilated cardiomyopathy_Homo sapiens_hsa054140.73676704
92MAPK signaling pathway_Homo sapiens_hsa040100.71907478
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70595498
94Endometrial cancer_Homo sapiens_hsa052130.68554231
95Vibrio cholerae infection_Homo sapiens_hsa051100.67813952
96Thyroid hormone synthesis_Homo sapiens_hsa049180.67416545
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67239230
98Glutathione metabolism_Homo sapiens_hsa004800.66131137
99Nitrogen metabolism_Homo sapiens_hsa009100.65531175
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.64477959
101Systemic lupus erythematosus_Homo sapiens_hsa053220.64253007
102Metabolic pathways_Homo sapiens_hsa011000.64173235
103Inositol phosphate metabolism_Homo sapiens_hsa005620.62958985
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.62199319
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62110152
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60398670
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60352688
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59823061
109Wnt signaling pathway_Homo sapiens_hsa043100.59703781
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58570068
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57628589
112Non-homologous end-joining_Homo sapiens_hsa034500.57333464
113Linoleic acid metabolism_Homo sapiens_hsa005910.56549049
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55672804
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55401568
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55149591
117mTOR signaling pathway_Homo sapiens_hsa041500.54176563
118Glucagon signaling pathway_Homo sapiens_hsa049220.53283262
119Ras signaling pathway_Homo sapiens_hsa040140.53239876
120Endocytosis_Homo sapiens_hsa041440.53126047
121Steroid biosynthesis_Homo sapiens_hsa001000.52451966
122Rap1 signaling pathway_Homo sapiens_hsa040150.52237118
123Cell cycle_Homo sapiens_hsa041100.51377047
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51224574
125Alcoholism_Homo sapiens_hsa050340.50878312
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50750812
127Fatty acid elongation_Homo sapiens_hsa000620.49617658
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49217770
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48867713
130Chemical carcinogenesis_Homo sapiens_hsa052040.48643496
131Type I diabetes mellitus_Homo sapiens_hsa049400.45110363
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44964240
133Colorectal cancer_Homo sapiens_hsa052100.44830795
134Ovarian steroidogenesis_Homo sapiens_hsa049130.44714690
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44322412
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43772149
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42600380
138Bile secretion_Homo sapiens_hsa049760.41716856
139Peroxisome_Homo sapiens_hsa041460.41706127
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41577853
141Prion diseases_Homo sapiens_hsa050200.41075123
142Insulin signaling pathway_Homo sapiens_hsa049100.40758412
143Caffeine metabolism_Homo sapiens_hsa002320.40327886
144Non-small cell lung cancer_Homo sapiens_hsa052230.40319336
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.39503732
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38023362
147beta-Alanine metabolism_Homo sapiens_hsa004100.37541647
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.36912085
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36340625
150Renal cell carcinoma_Homo sapiens_hsa052110.36333363
151Retinol metabolism_Homo sapiens_hsa008300.36164621
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35864467
153Hedgehog signaling pathway_Homo sapiens_hsa043400.33442810
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33339312
155VEGF signaling pathway_Homo sapiens_hsa043700.33048447
156Sulfur metabolism_Homo sapiens_hsa009200.31040350
157mRNA surveillance pathway_Homo sapiens_hsa030150.30808500
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.30267963
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30067438
160Hippo signaling pathway_Homo sapiens_hsa043900.29925834
161Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26162548
162Tight junction_Homo sapiens_hsa045300.26124030
163Melanoma_Homo sapiens_hsa052180.25906140
164Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25695044
165Regulation of autophagy_Homo sapiens_hsa041400.25384223
166TGF-beta signaling pathway_Homo sapiens_hsa043500.22676480
167Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.18776892
168Arachidonic acid metabolism_Homo sapiens_hsa005900.17982972
169Tyrosine metabolism_Homo sapiens_hsa003500.17281702
170Steroid hormone biosynthesis_Homo sapiens_hsa001400.16076864
171Vitamin B6 metabolism_Homo sapiens_hsa007500.15217996

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