SNRPGP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1high-density lipoprotein particle remodeling (GO:0034375)5.90875059
2regulation of relaxation of muscle (GO:1901077)5.37189960
3reverse cholesterol transport (GO:0043691)5.29147979
4regulation of triglyceride catabolic process (GO:0010896)4.96651845
5response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.84792154
6carnitine shuttle (GO:0006853)4.77901553
7phospholipid efflux (GO:0033700)4.68782393
8regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.62648174
9response to inactivity (GO:0014854)4.42522146
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.37619464
11sphingomyelin metabolic process (GO:0006684)4.26257021
12amino-acid betaine transport (GO:0015838)4.25600463
13carnitine transport (GO:0015879)4.25600463
14protein-lipid complex remodeling (GO:0034368)4.22536461
15macromolecular complex remodeling (GO:0034367)4.22536461
16plasma lipoprotein particle remodeling (GO:0034369)4.22536461
17phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.20857284
18regulation of NFAT protein import into nucleus (GO:0051532)4.20839061
19regulation of energy homeostasis (GO:2000505)4.15022826
20cholesterol efflux (GO:0033344)4.14450453
21fatty acid transmembrane transport (GO:1902001)4.13728027
22carnitine transmembrane transport (GO:1902603)4.10509335
23regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.94721920
24positive regulation of glycolytic process (GO:0045821)3.77990341
25regulation of cell communication by electrical coupling (GO:0010649)3.68994461
26regulation of skeletal muscle contraction (GO:0014819)3.66770086
27skeletal muscle adaptation (GO:0043501)3.60271833
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.56097543
29epithelial cilium movement (GO:0003351)3.53306318
30plasma lipoprotein particle assembly (GO:0034377)3.49626449
31NLS-bearing protein import into nucleus (GO:0006607)3.45946446
32mitotic sister chromatid cohesion (GO:0007064)3.43634124
33keratinocyte development (GO:0003334)3.42274755
34cellular response to ethanol (GO:0071361)3.41396695
35interkinetic nuclear migration (GO:0022027)3.39999047
36growth hormone receptor signaling pathway (GO:0060396)3.39911291
37S-adenosylmethionine metabolic process (GO:0046500)3.37634083
38intracellular lipid transport (GO:0032365)3.36298867
39establishment of protein localization to Golgi (GO:0072600)3.35444879
40protein-lipid complex assembly (GO:0065005)3.31262979
41COPII vesicle coating (GO:0048208)3.31116194
42quaternary ammonium group transport (GO:0015697)3.29043691
43cellular ketone body metabolic process (GO:0046950)3.27239543
44cytoplasmic microtubule organization (GO:0031122)3.26813314
45protein targeting to Golgi (GO:0000042)3.23290474
46macroautophagy (GO:0016236)3.22170843
47regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.21842167
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.21830682
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.21830682
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.21830682
51lactate metabolic process (GO:0006089)3.21577881
52cilium movement (GO:0003341)3.17480533
53regulation of type B pancreatic cell apoptotic process (GO:2000674)3.16626873
54regulation of female receptivity (GO:0045924)3.16248225
55vesicle transport along microtubule (GO:0047496)3.12840152
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12371706
57neural tube formation (GO:0001841)3.11798376
58plasma lipoprotein particle organization (GO:0071827)3.11711765
59muscle atrophy (GO:0014889)3.11416589
60cellular response to growth hormone stimulus (GO:0071378)3.11290028
61regulation of protein glycosylation (GO:0060049)3.10025076
62retrograde transport, vesicle recycling within Golgi (GO:0000301)3.08231267
63very-low-density lipoprotein particle assembly (GO:0034379)3.07013368
64cAMP catabolic process (GO:0006198)3.05482713
65nucleus localization (GO:0051647)3.04687272
66protein-lipid complex subunit organization (GO:0071825)3.03993186
67regulation of DNA endoreduplication (GO:0032875)3.02067984
68succinate metabolic process (GO:0006105)3.01574807
69tyrosine metabolic process (GO:0006570)2.99950475
70neuronal action potential propagation (GO:0019227)2.98649554
71lipoprotein transport (GO:0042953)2.96479331
72negative regulation of dendrite morphogenesis (GO:0050774)2.95674178
73ketone body metabolic process (GO:1902224)2.91250841
74negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.89239500
75regulation of digestive system process (GO:0044058)2.85668463
76sarcoplasmic reticulum calcium ion transport (GO:0070296)2.82438130
77intra-Golgi vesicle-mediated transport (GO:0006891)2.82292554
78coenzyme catabolic process (GO:0009109)2.81765711
79embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79063130
80triglyceride homeostasis (GO:0070328)2.78636459
81acylglycerol homeostasis (GO:0055090)2.78636459
82striated muscle atrophy (GO:0014891)2.75369795
83negative regulation of protein activation cascade (GO:2000258)2.74253671
84drug catabolic process (GO:0042737)2.73436546
85negative regulation of complement activation (GO:0045916)2.72466107
86opioid receptor signaling pathway (GO:0038003)2.70454753
87cyclic nucleotide catabolic process (GO:0009214)2.69955583
88prostate gland growth (GO:0060736)2.69712344
89developmental pigmentation (GO:0048066)2.68403873
90cilium or flagellum-dependent cell motility (GO:0001539)2.67889799
91regulation of cholesterol esterification (GO:0010872)2.67883056
92actin-myosin filament sliding (GO:0033275)2.65197840
93muscle filament sliding (GO:0030049)2.65197840
94negative regulation of sterol transport (GO:0032372)2.64838490
95negative regulation of cholesterol transport (GO:0032375)2.64838490
96hepatocyte differentiation (GO:0070365)2.64673902
97actin-mediated cell contraction (GO:0070252)2.62813282
98regulation of hexokinase activity (GO:1903299)2.57514702
99regulation of glucokinase activity (GO:0033131)2.57514702
100genitalia morphogenesis (GO:0035112)2.57106412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.86654423
2VDR_22108803_ChIP-Seq_LS180_Human3.10949500
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86839976
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76521291
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.71225867
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58667204
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.39900729
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38965271
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30146159
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15434339
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.12617913
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11287381
13IGF1R_20145208_ChIP-Seq_DFB_Human2.09666298
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04535392
15GBX2_23144817_ChIP-Seq_PC3_Human2.03281890
16SUZ12_27294783_Chip-Seq_NPCs_Mouse1.97252092
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86314222
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85141522
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.84105427
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83961664
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82390454
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81793357
23GATA1_22025678_ChIP-Seq_K562_Human1.74853370
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.74070218
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.68979781
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68294879
27SMAD4_21799915_ChIP-Seq_A2780_Human1.68021755
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65954853
29CBP_20019798_ChIP-Seq_JUKART_Human1.65954853
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65636659
31TCF4_23295773_ChIP-Seq_U87_Human1.65604198
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64196661
33TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.62609439
34FUS_26573619_Chip-Seq_HEK293_Human1.61643302
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.61269964
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.57709784
37TP53_16413492_ChIP-PET_HCT116_Human1.57540151
38ER_23166858_ChIP-Seq_MCF-7_Human1.56552312
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56542199
40STAT3_23295773_ChIP-Seq_U87_Human1.54359681
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.53225723
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48157164
43P300_19829295_ChIP-Seq_ESCs_Human1.47481193
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.45376791
45BCAT_22108803_ChIP-Seq_LS180_Human1.44319059
46FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43984970
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43178815
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42910820
49P53_22387025_ChIP-Seq_ESCs_Mouse1.42290063
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39078592
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38957670
52RXR_22108803_ChIP-Seq_LS180_Human1.37337881
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.36620552
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36522344
55TAF15_26573619_Chip-Seq_HEK293_Human1.35896348
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35713432
57P300_18555785_Chip-Seq_ESCs_Mouse1.34923500
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.34256579
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.33860062
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32568202
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32321416
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.31112819
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30373801
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30373801
65RUNX_20019798_ChIP-Seq_JUKART_Human1.29846671
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28954690
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28647010
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26501904
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.25588115
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.24847586
71SOX2_18555785_Chip-Seq_ESCs_Mouse1.24762828
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24029970
73SOX2_19829295_ChIP-Seq_ESCs_Human1.23933237
74NANOG_19829295_ChIP-Seq_ESCs_Human1.23933237
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.23627461
76FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.21499147
77VDR_24787735_ChIP-Seq_THP-1_Human1.19713325
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19569849
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.19333451
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17169525
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16326917
82CTCF_18555785_Chip-Seq_ESCs_Mouse1.12559766
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.12368527
84AR_25329375_ChIP-Seq_VCAP_Human1.12179468
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.12058767
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11044866
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.10131610
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10068248
89AHR_22903824_ChIP-Seq_MCF-7_Human1.09837416
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.09437564
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09342976
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09179535
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.09139479
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08459448
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08459448
96ZFX_18555785_Chip-Seq_ESCs_Mouse1.07407769
97SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07192829
98NMYC_18555785_Chip-Seq_ESCs_Mouse1.07089787
99IRF8_22096565_ChIP-ChIP_GC-B_Human1.07010144
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05890467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol4.55688997
2MP0000372_irregular_coat_pigmentation3.55388469
3MP0003646_muscle_fatigue3.34854899
4MP0009840_abnormal_foam_cell3.24317302
5MP0004381_abnormal_hair_follicle3.18244080
6MP0004145_abnormal_muscle_electrophysio3.12161817
7MP0003136_yellow_coat_color3.08368422
8MP0000751_myopathy3.00678431
9MP0009780_abnormal_chondrocyte_physiolo2.96638867
10MP0004270_analgesia2.91036038
11MP0005174_abnormal_tail_pigmentation2.65142714
12MP0000749_muscle_degeneration2.64771782
13MP0002876_abnormal_thyroid_physiology2.30963473
14MP0003195_calcinosis2.22397538
15MP0004130_abnormal_muscle_cell2.05441018
16MP0003045_fibrosis1.99739548
17MP0004510_myositis1.97004748
18MP0010329_abnormal_lipoprotein_level1.93093788
19MP0002928_abnormal_bile_duct1.86512277
20MP0000003_abnormal_adipose_tissue1.86165836
21MP0004233_abnormal_muscle_weight1.80369210
22MP0003868_abnormal_feces_composition1.74721003
23MP0003252_abnormal_bile_duct1.73972411
24MP0005360_urolithiasis1.73946062
25MP0005171_absent_coat_pigmentation1.71851427
26MP0000569_abnormal_digit_pigmentation1.70061854
27MP0000013_abnormal_adipose_tissue1.67153785
28MP0003787_abnormal_imprinting1.61358719
29MP0002106_abnormal_muscle_physiology1.58613403
30MP0002138_abnormal_hepatobiliary_system1.52524420
31MP0002909_abnormal_adrenal_gland1.51933034
32MP0001502_abnormal_circadian_rhythm1.49841223
33MP0002269_muscular_atrophy1.48396019
34MP0000015_abnormal_ear_pigmentation1.47019331
35MP0001666_abnormal_nutrient_absorption1.46184516
36MP0000747_muscle_weakness1.44949636
37MP0002638_abnormal_pupillary_reflex1.44838097
38MP0000371_diluted_coat_color1.41728306
39MP0002837_dystrophic_cardiac_calcinosis1.41358183
40MP0005408_hypopigmentation1.37013104
41MP0005330_cardiomyopathy1.31120332
42MP0005310_abnormal_salivary_gland1.30234867
43MP0001661_extended_life_span1.29249371
44MP0000759_abnormal_skeletal_muscle1.28376728
45MP0005075_abnormal_melanosome_morpholog1.28374704
46MP0005369_muscle_phenotype1.26719695
47MP0000427_abnormal_hair_cycle1.25985160
48MP0008775_abnormal_heart_ventricle1.24856477
49MP0005365_abnormal_bile_salt1.24452604
50MP0003950_abnormal_plasma_membrane1.19935550
51MP0003300_gastrointestinal_ulcer1.18382609
52MP0002095_abnormal_skin_pigmentation1.17350201
53MP0001984_abnormal_olfaction1.13310012
54MP0002971_abnormal_brown_adipose1.11075855
55MP0006072_abnormal_retinal_apoptosis1.10272875
56MP0002118_abnormal_lipid_homeostasis1.10035016
57MP0002168_other_aberrant_phenotype1.09800922
58MP0004087_abnormal_muscle_fiber1.09740037
59MP0004036_abnormal_muscle_relaxation1.08510465
60MP0004142_abnormal_muscle_tone1.08401546
61MP0005379_endocrine/exocrine_gland_phen1.07913297
62MP0006036_abnormal_mitochondrial_physio1.06818033
63MP0002166_altered_tumor_susceptibility1.04034885
64MP0005332_abnormal_amino_acid1.02920664
65MP0003123_paternal_imprinting1.01454895
66MP0008877_abnormal_DNA_methylation0.98288347
67MP0005253_abnormal_eye_physiology0.98271601
68MP0003221_abnormal_cardiomyocyte_apopto0.98109820
69MP0002078_abnormal_glucose_homeostasis0.98068415
70MP0002163_abnormal_gland_morphology0.97031011
71MP0005535_abnormal_body_temperature0.96312538
72MP0005085_abnormal_gallbladder_physiolo0.94877985
73MP0005670_abnormal_white_adipose0.92061759
74MP0002822_catalepsy0.90967207
75MP0002108_abnormal_muscle_morphology0.89265509
76MP0002734_abnormal_mechanical_nocicepti0.88203386
77MP0005220_abnormal_exocrine_pancreas0.87859213
78MP0003879_abnormal_hair_cell0.86563844
79MP0005620_abnormal_muscle_contractility0.86024555
80MP0003122_maternal_imprinting0.85574670
81MP0005551_abnormal_eye_electrophysiolog0.84248710
82MP0003656_abnormal_erythrocyte_physiolo0.83376393
83MP0002693_abnormal_pancreas_physiology0.82104309
84MP0002127_abnormal_cardiovascular_syste0.81033632
85MP0002009_preneoplasia0.80105048
86MP0005334_abnormal_fat_pad0.77909221
87MP0000733_abnormal_muscle_development0.77661018
88MP0005375_adipose_tissue_phenotype0.77387395
89MP0002332_abnormal_exercise_endurance0.76571592
90MP0005451_abnormal_body_composition0.75387962
91MP0003121_genomic_imprinting0.70274116
92MP0001764_abnormal_homeostasis0.70077534
93MP0005084_abnormal_gallbladder_morpholo0.70000732
94MP0009046_muscle_twitch0.69455538
95MP0003866_abnormal_defecation0.69283909
96MP0002938_white_spotting0.67963191
97MP0005248_abnormal_Harderian_gland0.67350175
98MP0002557_abnormal_social/conspecific_i0.67253100
99MP0001501_abnormal_sleep_pattern0.66987005
100MP0005266_abnormal_metabolism0.66911565

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)6.68911105
2Nemaline bodies (HP:0003798)6.47452737
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.74712368
4Muscle fiber inclusion bodies (HP:0100299)5.54493676
5Exercise-induced myalgia (HP:0003738)5.34666233
6Hypobetalipoproteinemia (HP:0003563)4.55467905
7Hepatoblastoma (HP:0002884)4.30922011
8Papillary thyroid carcinoma (HP:0002895)4.10464706
9Type 1 muscle fiber predominance (HP:0003803)3.98866642
10Exercise-induced muscle cramps (HP:0003710)3.89353627
11Hyperkalemia (HP:0002153)3.63621425
12Septo-optic dysplasia (HP:0100842)3.57129521
13Difficulty running (HP:0009046)3.45759540
14Long clavicles (HP:0000890)3.43757813
15Albinism (HP:0001022)3.38526714
16Hyperlipoproteinemia (HP:0010980)3.34257234
17Abnormality of the calf musculature (HP:0001430)3.19026659
18Fetal akinesia sequence (HP:0001989)3.17763837
19Abnormality of the musculature of the pelvis (HP:0001469)3.12920405
20Abnormality of the hip-girdle musculature (HP:0001445)3.12920405
21Calf muscle hypertrophy (HP:0008981)3.10136619
22EMG: myopathic abnormalities (HP:0003458)3.07483035
23Malignant hyperthermia (HP:0002047)3.00038260
24Muscle hypertrophy of the lower extremities (HP:0008968)2.95719517
25Hypolipoproteinemia (HP:0010981)2.92788426
26Decreased lacrimation (HP:0000633)2.91935607
27Blue irides (HP:0000635)2.90784042
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.76364135
29Epidermoid cyst (HP:0200040)2.75869647
30Rimmed vacuoles (HP:0003805)2.75098420
31Large for gestational age (HP:0001520)2.68781875
32Maternal diabetes (HP:0009800)2.68109470
33Pigmentary retinal degeneration (HP:0001146)2.68046675
34Gaze-evoked nystagmus (HP:0000640)2.61966670
35Fair hair (HP:0002286)2.61338640
36Thyroid carcinoma (HP:0002890)2.58046131
37Nonprogressive disorder (HP:0003680)2.55337533
38Pelvic girdle muscle weakness (HP:0003749)2.50512806
39Myopathic facies (HP:0002058)2.48046147
40Fatigable weakness (HP:0003473)2.45403684
41Abnormality of the neuromuscular junction (HP:0003398)2.45403684
42Hypoplastic iliac wings (HP:0002866)2.41567058
43Akinesia (HP:0002304)2.37609040
44Pancreatic islet-cell hyperplasia (HP:0004510)2.36181065
45Generalized hypopigmentation of hair (HP:0011358)2.33655695
46Rhabdomyolysis (HP:0003201)2.30741656
47Neck muscle weakness (HP:0000467)2.30251365
48Hypomagnesemia (HP:0002917)2.27952465
49Pheochromocytoma (HP:0002666)2.26913146
50Myoglobinuria (HP:0002913)2.25837060
51Anosmia (HP:0000458)2.25602374
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.25591927
53Anhidrosis (HP:0000970)2.23010012
54White forelock (HP:0002211)2.22094847
55Truncal obesity (HP:0001956)2.21912601
56Patchy hypopigmentation of hair (HP:0011365)2.21589281
57Neoplasm of the adrenal gland (HP:0100631)2.20942487
58Intestinal atresia (HP:0011100)2.19964949
59Volvulus (HP:0002580)2.18037668
60Frequent falls (HP:0002359)2.16527222
61Shoulder girdle muscle weakness (HP:0003547)2.13326169
62Muscular dystrophy (HP:0003560)2.09179060
63Ketoacidosis (HP:0001993)2.04709455
64Neoplasm of the adrenal cortex (HP:0100641)2.03087077
65Subaortic stenosis (HP:0001682)2.01679226
66Abnormality of the left ventricular outflow tract (HP:0011103)2.01679226
67Tetany (HP:0001281)1.99066053
68Generalized muscle weakness (HP:0003324)1.98990125
69Optic nerve hypoplasia (HP:0000609)1.98826139
70Type 2 muscle fiber atrophy (HP:0003554)1.97476653
71Hamartoma of the eye (HP:0010568)1.96463156
72Hyperphosphatemia (HP:0002905)1.95480985
73Neuroendocrine neoplasm (HP:0100634)1.93750053
74Abnormality of potassium homeostasis (HP:0011042)1.93063309
75Abnormality of chloride homeostasis (HP:0011422)1.88922614
76Popliteal pterygium (HP:0009756)1.88283595
77Alacrima (HP:0000522)1.87994409
78Abnormal pancreas size (HP:0012094)1.84906060
79Abnormality of the renal cortex (HP:0011035)1.83388156
80Truncal ataxia (HP:0002078)1.82929315
81Hyperventilation (HP:0002883)1.81433853
82Increased density of long bones (HP:0006392)1.80710100
83Generalized hypopigmentation (HP:0007513)1.79709637
84Insulin-resistant diabetes mellitus (HP:0000831)1.79647800
85Increased connective tissue (HP:0009025)1.77279715
86Distal arthrogryposis (HP:0005684)1.76894456
87Hyporeflexia of lower limbs (HP:0002600)1.76167652
88Gowers sign (HP:0003391)1.75689602
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74875995
90Increased variability in muscle fiber diameter (HP:0003557)1.74212628
91Ketosis (HP:0001946)1.73640040
92Bronchiectasis (HP:0002110)1.72229193
93Abnormality of endocrine pancreas physiology (HP:0012093)1.71984562
94Abnormality of the pancreatic islet cells (HP:0006476)1.71984562
95Delayed puberty (HP:0000823)1.70913367
96Thyroiditis (HP:0100646)1.70079488
97Rhinitis (HP:0012384)1.69694912
98Absent septum pellucidum (HP:0001331)1.68644647
99Hypoplasia of the iris (HP:0007676)1.67624695
100Severe visual impairment (HP:0001141)1.67025755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.68435158
2FRK4.92226716
3PIK3CG3.72573156
4WNK33.36154988
5ACVR1B3.35669253
6MUSK3.19053119
7MAP3K72.86515810
8FGFR22.83762448
9EPHA32.68375310
10ADRBK22.63183820
11NLK2.59037654
12TNIK2.37806380
13BRD42.31532442
14FGFR32.20073144
15PRKD32.10074441
16PINK11.99099296
17PHKG11.61804901
18PHKG21.61804901
19NEK61.58148402
20MAP3K101.56257150
21MARK31.49996027
22BRSK21.40575185
23SGK21.38134957
24PRKAA21.38025365
25MAP3K21.28593798
26MAP3K41.24896944
27FGFR41.23835767
28FER1.19732804
29PTK2B1.11534783
30JAK11.01416469
31STK390.99550061
32PASK0.96237896
33SGK30.94696628
34SGK2230.91552850
35SGK4940.91552850
36CAMKK20.91345024
37MST40.87197648
38BCR0.80405228
39MARK20.80169047
40ERBB30.79587634
41HIPK20.79110017
42DAPK20.75676495
43SCYL20.73517891
44STK38L0.68064809
45EIF2AK30.66127930
46PRKAA10.63711332
47WNK10.62823892
48MELK0.60769957
49EPHB10.59732960
50CAMK40.58425298
51PAK30.57435776
52NME10.55991019
53STK110.53613206
54MAPK110.52552621
55CDK120.52474327
56MAP2K60.52335606
57SGK10.51050839
58IRAK20.49025468
59OXSR10.48872784
60PIK3CA0.48657064
61STK380.47636545
62PLK40.46529829
63MAP3K140.46010078
64PDK20.45820095
65RET0.45443846
66NEK90.45180365
67FGFR10.45143841
68JAK20.44776907
69RPS6KB10.43304753
70MAP4K10.42813308
71ITK0.41553645
72TRPM70.41234304
73MAPK130.40484752
74NTRK30.39784695
75TXK0.39366792
76CCNB10.37725255
77PRKCZ0.37340997
78TAOK30.36851627
79INSRR0.36219692
80YES10.34301947
81MAP4K20.33366525
82IRAK10.32557408
83PRKCH0.31620547
84CDK80.27299873
85RPS6KA30.27125990
86PRKG10.26505995
87CDC42BPA0.26329389
88PRKCI0.26135584
89CSNK1A1L0.25014002
90TTN0.24812148
91TYK20.24045747
92MAP2K10.23900497
93WNK40.23812570
94PRKCQ0.23692144
95PKN10.22738582
96PRKACB0.22697631
97MARK10.21888915
98UHMK10.21003721
99MINK10.20571362
100MAPK70.18902992

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047103.93782172
2ABC transporters_Homo sapiens_hsa020103.42587426
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.81926074
4Fat digestion and absorption_Homo sapiens_hsa049752.74894055
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52818687
6Vitamin digestion and absorption_Homo sapiens_hsa049772.37502625
7Vitamin B6 metabolism_Homo sapiens_hsa007502.33182838
8Butanoate metabolism_Homo sapiens_hsa006502.24471064
9Propanoate metabolism_Homo sapiens_hsa006401.89526860
10Insulin resistance_Homo sapiens_hsa049311.78346763
11Linoleic acid metabolism_Homo sapiens_hsa005911.76086967
12Tryptophan metabolism_Homo sapiens_hsa003801.73018785
13Glycerolipid metabolism_Homo sapiens_hsa005611.72274022
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70768260
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64022183
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.62667647
17Regulation of autophagy_Homo sapiens_hsa041401.60183355
18Inositol phosphate metabolism_Homo sapiens_hsa005621.54965263
19Complement and coagulation cascades_Homo sapiens_hsa046101.53077820
20Fatty acid degradation_Homo sapiens_hsa000711.50597685
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.44129163
22Glucagon signaling pathway_Homo sapiens_hsa049221.42225489
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41749546
24Pancreatic secretion_Homo sapiens_hsa049721.40804248
25Renin secretion_Homo sapiens_hsa049241.34420069
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.34338047
27Non-homologous end-joining_Homo sapiens_hsa034501.33042818
28Peroxisome_Homo sapiens_hsa041461.31753009
29PPAR signaling pathway_Homo sapiens_hsa033201.24095059
30mTOR signaling pathway_Homo sapiens_hsa041501.22967895
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22876680
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22857369
33FoxO signaling pathway_Homo sapiens_hsa040681.19903689
34Fructose and mannose metabolism_Homo sapiens_hsa000511.19095149
35Insulin signaling pathway_Homo sapiens_hsa049101.18381303
36Lysine degradation_Homo sapiens_hsa003101.11934559
37Dorso-ventral axis formation_Homo sapiens_hsa043201.01651074
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00817462
39Galactose metabolism_Homo sapiens_hsa000520.99938663
40Starch and sucrose metabolism_Homo sapiens_hsa005000.99064902
41Adipocytokine signaling pathway_Homo sapiens_hsa049200.92863444
42Calcium signaling pathway_Homo sapiens_hsa040200.89299546
43Insulin secretion_Homo sapiens_hsa049110.87236305
44Circadian entrainment_Homo sapiens_hsa047130.86685716
45Ether lipid metabolism_Homo sapiens_hsa005650.86210078
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85321685
47beta-Alanine metabolism_Homo sapiens_hsa004100.82054264
48Type II diabetes mellitus_Homo sapiens_hsa049300.80057193
49Sphingolipid metabolism_Homo sapiens_hsa006000.79652770
50Hedgehog signaling pathway_Homo sapiens_hsa043400.77873605
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76902977
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76426757
53Fatty acid metabolism_Homo sapiens_hsa012120.74623061
54Chemical carcinogenesis_Homo sapiens_hsa052040.73696585
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72155299
56Long-term depression_Homo sapiens_hsa047300.70860954
57AMPK signaling pathway_Homo sapiens_hsa041520.69928569
58Tyrosine metabolism_Homo sapiens_hsa003500.69168073
59GnRH signaling pathway_Homo sapiens_hsa049120.68125158
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67775871
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67106266
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66999035
63Taste transduction_Homo sapiens_hsa047420.65328048
64Mineral absorption_Homo sapiens_hsa049780.64275114
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60501471
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.59578628
67Renin-angiotensin system_Homo sapiens_hsa046140.58141173
68Protein export_Homo sapiens_hsa030600.57725684
69HIF-1 signaling pathway_Homo sapiens_hsa040660.56956621
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53753511
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.53635748
72Caffeine metabolism_Homo sapiens_hsa002320.51657761
73Prostate cancer_Homo sapiens_hsa052150.50986181
74Salivary secretion_Homo sapiens_hsa049700.50304223
75Olfactory transduction_Homo sapiens_hsa047400.50265422
76Endometrial cancer_Homo sapiens_hsa052130.50148604
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48074590
78Fatty acid biosynthesis_Homo sapiens_hsa000610.47349702
79Tight junction_Homo sapiens_hsa045300.44341156
80Morphine addiction_Homo sapiens_hsa050320.42755013
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40947005
82Choline metabolism in cancer_Homo sapiens_hsa052310.37723072
83Retinol metabolism_Homo sapiens_hsa008300.37692015
84Protein digestion and absorption_Homo sapiens_hsa049740.37391192
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36774827
86Arginine and proline metabolism_Homo sapiens_hsa003300.36164400
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35843394
88Histidine metabolism_Homo sapiens_hsa003400.35666754
89Melanogenesis_Homo sapiens_hsa049160.35599227
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35522642
91Bile secretion_Homo sapiens_hsa049760.34897120
92Dopaminergic synapse_Homo sapiens_hsa047280.33763894
93Oxytocin signaling pathway_Homo sapiens_hsa049210.33293507
94Prolactin signaling pathway_Homo sapiens_hsa049170.32891512
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31232995
96T cell receptor signaling pathway_Homo sapiens_hsa046600.30991282
97Amphetamine addiction_Homo sapiens_hsa050310.30895383
98RNA degradation_Homo sapiens_hsa030180.30664591
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30597276
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.30373415

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