SNRPGP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ventricular trabecula myocardium morphogenesis (GO:0003222)9.74342029
2telomere maintenance via telomerase (GO:0007004)9.31208337
3negative regulation of cardiac muscle cell apoptotic process (GO:0010667)8.72548359
4negative regulation of DNA biosynthetic process (GO:2000279)8.64946054
5regulation of telomere maintenance (GO:0032204)7.92163178
6heart trabecula morphogenesis (GO:0061384)7.84733655
7DNA damage response, detection of DNA damage (GO:0042769)7.52284971
8positive regulation of response to oxidative stress (GO:1902884)7.24521554
9positive regulation of cellular response to oxidative stress (GO:1900409)7.24521554
10artery development (GO:0060840)7.03750284
11RNA-dependent DNA replication (GO:0006278)6.94222746
12positive regulation of DNA biosynthetic process (GO:2000573)6.91240247
13lymphangiogenesis (GO:0001946)6.76814186
14trabecula morphogenesis (GO:0061383)6.32623177
15cell adhesion mediated by integrin (GO:0033627)6.20616179
16embryonic foregut morphogenesis (GO:0048617)5.89095480
17response to ischemia (GO:0002931)5.74352350
18endothelial cell differentiation (GO:0045446)5.63632258
19regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.55439779
20interkinetic nuclear migration (GO:0022027)5.48913545
21negative regulation of striated muscle cell apoptotic process (GO:0010664)5.38174405
22regulation of cardiac muscle cell apoptotic process (GO:0010665)5.35066362
23response to acidic pH (GO:0010447)5.20021161
24intra-S DNA damage checkpoint (GO:0031573)5.11716392
25hemidesmosome assembly (GO:0031581)4.96103447
26cardiac right ventricle morphogenesis (GO:0003215)4.93764259
27renal system development (GO:0072001)4.93415502
28organ growth (GO:0035265)4.72253512
29activin receptor signaling pathway (GO:0032924)4.70384323
30superoxide anion generation (GO:0042554)4.68459176
31cell migration in hindbrain (GO:0021535)4.55693118
32protein localization to lysosome (GO:0061462)4.12851220
33protein localization to vacuole (GO:0072665)4.12851220
34regulation of striated muscle cell apoptotic process (GO:0010662)4.11816357
35cellular response to pH (GO:0071467)4.11433641
36activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.06421317
37brain morphogenesis (GO:0048854)4.05643373
38nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)4.00425514
39heart field specification (GO:0003128)3.98599086
40secondary heart field specification (GO:0003139)3.98599086
41cerebral cortex neuron differentiation (GO:0021895)3.92485035
42single strand break repair (GO:0000012)3.86253961
43respiratory burst (GO:0045730)3.75037744
44gastrulation with mouth forming second (GO:0001702)3.69869023
45positive regulation of Rho protein signal transduction (GO:0035025)3.67012739
46negative regulation of protein localization to cell surface (GO:2000009)3.46067448
47retina development in camera-type eye (GO:0060041)3.39629572
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38225535
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.38225535
50NADH dehydrogenase complex assembly (GO:0010257)3.38225535
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34011677
52response to increased oxygen levels (GO:0036296)3.33708246
53response to hyperoxia (GO:0055093)3.33708246
54regulation of DNA biosynthetic process (GO:2000278)3.29193593
55layer formation in cerebral cortex (GO:0021819)3.29186016
56type B pancreatic cell development (GO:0003323)3.26384267
57pancreas development (GO:0031016)3.26183620
58filopodium assembly (GO:0046847)3.24329921
59positive regulation of TOR signaling (GO:0032008)3.22646557
60carnitine shuttle (GO:0006853)3.22289593
61negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.21686113
62negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.16891971
63DNA replication checkpoint (GO:0000076)3.15994601
64intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.15170347
65regulation of protein heterodimerization activity (GO:0043497)3.13282976
66cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)3.12585842
67ventricular cardiac muscle cell development (GO:0055015)3.11894481
68glycerophospholipid catabolic process (GO:0046475)3.11525880
69nucleotide transmembrane transport (GO:1901679)3.09923540
70regulation of smooth muscle cell differentiation (GO:0051150)3.09880740
71nodal signaling pathway (GO:0038092)3.02455047
72telomere maintenance via telomere lengthening (GO:0010833)3.00270703
73protein polyglutamylation (GO:0018095)2.99881214
74cardiac muscle contraction (GO:0060048)2.94780389
75histone-serine phosphorylation (GO:0035404)2.93113509
76nucleus localization (GO:0051647)2.90431614
77insulin secretion (GO:0030073)2.89666740
78positive regulation vascular endothelial growth factor production (GO:0010575)2.88589008
79regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.81926436
80exogenous drug catabolic process (GO:0042738)2.78266045
81fatty acid transmembrane transport (GO:1902001)2.69874356
82type B pancreatic cell proliferation (GO:0044342)2.64462298
83positive regulation of cardiac muscle cell proliferation (GO:0060045)2.63742117
84positive regulation of small GTPase mediated signal transduction (GO:0051057)2.62567003
85specification of organ identity (GO:0010092)2.60036667
86negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59822681
87negative regulation of DNA replication (GO:0008156)2.58097060
88viral genome replication (GO:0019079)2.57922134
89cytoplasmic sequestering of transcription factor (GO:0042994)2.56775194
90ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.56225886
91peptide biosynthetic process (GO:0043043)2.54698170
92positive regulation of cardiac muscle tissue growth (GO:0055023)2.52024329
93diol metabolic process (GO:0034311)2.51126207
94cell proliferation in forebrain (GO:0021846)2.48964623
95regulation of telomere maintenance via telomerase (GO:0032210)16.0141149
96negative regulation of telomerase activity (GO:0051974)15.6577877
97DNA damage induced protein phosphorylation (GO:0006975)14.8947122
98negative regulation of telomere maintenance (GO:0032205)13.6727424
99regulation of helicase activity (GO:0051095)12.7730344
100regulation of telomerase activity (GO:0051972)10.1759522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.21416291
2HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse6.10896679
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse6.06723752
4E2F7_22180533_ChIP-Seq_HELA_Human4.88211142
5GBX2_23144817_ChIP-Seq_PC3_Human3.07838328
6ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.65241472
7TP53_16413492_ChIP-PET_HCT116_Human2.28682777
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.13772052
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11936376
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.09443682
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.4305676
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse10.1164523
13CBX2_27304074_Chip-Seq_ESCs_Mouse1.90838574
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90685914
15TAF15_26573619_Chip-Seq_HEK293_Human1.89934676
16GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.59166934
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52278245
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51419530
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.46887273
20MYC_18940864_ChIP-ChIP_HL60_Human1.40731373
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.38095429
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.33289395
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29215318
24CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.27917152
25AR_21572438_ChIP-Seq_LNCaP_Human1.27596353
26STAT3_23295773_ChIP-Seq_U87_Human1.27454239
27ER_23166858_ChIP-Seq_MCF-7_Human1.19379557
28RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17755660
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17404302
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17194260
31FUS_26573619_Chip-Seq_HEK293_Human1.16363376
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.16158452
33CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15746466
34P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15190933
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14787019
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.13346177
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11762563
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09706157
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04041250
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.02646774
41SOX2_21211035_ChIP-Seq_LN229_Human1.01503509
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01098357
43EWS_26573619_Chip-Seq_HEK293_Human1.00403287
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99495662
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97025131
46CBP_20019798_ChIP-Seq_JUKART_Human0.97025131
47RUNX2_22187159_ChIP-Seq_PCA_Human0.93894177
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93879134
49TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92608872
50LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92583129
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91512774
52TP53_18474530_ChIP-ChIP_U2OS_Human0.89357308
53ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88500837
54SMAD4_21799915_ChIP-Seq_A2780_Human0.88278768
55FLI1_21867929_ChIP-Seq_TH2_Mouse0.87961223
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87053522
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85519371
58IGF1R_20145208_ChIP-Seq_DFB_Human0.83344844
59SMAD3_21741376_ChIP-Seq_HESCs_Human0.83169370
60REST_21632747_ChIP-Seq_MESCs_Mouse0.82993971
61CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80266415
62TCF4_22108803_ChIP-Seq_LS180_Human0.79991267
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79845761
64TCF4_23295773_ChIP-Seq_U87_Human0.78269637
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76612443
66GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.75183927
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74790098
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74364073
69P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.72192908
70EST1_17652178_ChIP-ChIP_JURKAT_Human0.70985352
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.69629580
72SALL4_22934838_ChIP-ChIP_CD34+_Human0.69230150
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.68132250
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.67636310
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67496695
76NFIB_24661679_ChIP-Seq_LUNG_Mouse0.65985885
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64479904
78P53_21459846_ChIP-Seq_SAOS-2_Human0.64377262
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.63666221
80CMYC_18555785_Chip-Seq_ESCs_Mouse0.63477361
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.62375639
82RUNX_20019798_ChIP-Seq_JUKART_Human0.62271387
83NCOR_22424771_ChIP-Seq_293T_Human0.61435307
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.61298299
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.60326953
86E2F1_18555785_Chip-Seq_ESCs_Mouse0.60310977
87MYC_27129775_Chip-Seq_CORNEA_Mouse0.60304102
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.59339043
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.58966038
90ZNF274_21170338_ChIP-Seq_K562_Hela0.58742389
91JUN_21703547_ChIP-Seq_K562_Human0.58681978
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.56973533
93TP53_22573176_ChIP-Seq_HFKS_Human0.56791389
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.56143059
95ERA_21632823_ChIP-Seq_H3396_Human0.56113679
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.55567772
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.55235000
98AR_25329375_ChIP-Seq_VCAP_Human0.54832549
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.54560961
100CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.54088625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004133_heterotaxia5.91240818
2MP0002163_abnormal_gland_morphology5.73191578
3MP0004270_analgesia5.47334909
4MP0003880_abnormal_central_pattern4.23195200
5MP0008775_abnormal_heart_ventricle3.74203837
6MP0002127_abnormal_cardiovascular_syste3.65471877
7MP0005379_endocrine/exocrine_gland_phen3.44104323
8MP0002102_abnormal_ear_morphology3.42979277
9MP0003763_abnormal_thymus_physiology3.23771629
10MP0005595_abnormal_vascular_smooth3.17331592
11MP0000372_irregular_coat_pigmentation2.88446040
12MP0006276_abnormal_autonomic_nervous2.88416541
13MP0003646_muscle_fatigue2.77646111
14MP0005171_absent_coat_pigmentation2.69102940
15MP0004272_abnormal_basement_membrane2.66304220
16MP0003806_abnormal_nucleotide_metabolis2.46545579
17MP0003195_calcinosis2.29671856
18MP0003136_yellow_coat_color2.18755091
19MP0008875_abnormal_xenobiotic_pharmacok2.01943074
20MP0004883_abnormal_blood_vessel2.01677195
21MP0000647_abnormal_sebaceous_gland1.96315546
22MP0008995_early_reproductive_senescence1.95550319
23MP0005646_abnormal_pituitary_gland1.93517688
24MP0000749_muscle_degeneration1.81564978
25MP0004147_increased_porphyrin_level1.80791015
26MP0003890_abnormal_embryonic-extraembry1.80547682
27MP0005330_cardiomyopathy1.62557384
28MP0003448_altered_tumor_morphology1.54739927
29MP0002734_abnormal_mechanical_nocicepti1.48077798
30MP0002089_abnormal_postnatal_growth/wei1.42360532
31MP0009384_cardiac_valve_regurgitation1.41659261
32MP0002168_other_aberrant_phenotype1.41214707
33MP0009745_abnormal_behavioral_response1.37905240
34MP0000343_altered_response_to1.34738552
35MP0006072_abnormal_retinal_apoptosis1.28633999
36MP0000631_abnormal_neuroendocrine_gland1.28168295
37MP0002972_abnormal_cardiac_muscle1.24322057
38MP0001324_abnormal_eye_pigmentation1.24268899
39MP0008874_decreased_physiological_sensi1.23575837
40MP0005620_abnormal_muscle_contractility1.23005460
41MP0002876_abnormal_thyroid_physiology1.18624531
42MP0005075_abnormal_melanosome_morpholog1.18066032
43MP0000249_abnormal_blood_vessel1.14698414
44MP0000920_abnormal_myelination1.11258786
45MP0002822_catalepsy1.10806706
46MP0004145_abnormal_muscle_electrophysio1.09671468
47MP0000230_abnormal_systemic_arterial1.09629516
48MP0002638_abnormal_pupillary_reflex1.05441851
49MP0009697_abnormal_copulation1.05054591
50MP0005551_abnormal_eye_electrophysiolog1.03429878
51MP0005197_abnormal_uvea_morphology1.02646761
52MP0000778_abnormal_nervous_system1.02537781
53MP0008057_abnormal_DNA_replication0.99252282
54MP0002064_seizures0.98195145
55MP0003186_abnormal_redox_activity0.97886793
56MP0001485_abnormal_pinna_reflex0.96704260
57MP0002095_abnormal_skin_pigmentation0.91877545
58MP0009250_abnormal_appendicular_skeleto0.91339596
59MP0004484_altered_response_of0.88818608
60MP0005195_abnormal_posterior_eye0.88684345
61MP0010630_abnormal_cardiac_muscle0.86900686
62MP0005385_cardiovascular_system_phenoty0.83253332
63MP0001544_abnormal_cardiovascular_syste0.83253332
64MP0004811_abnormal_neuron_physiology0.81631371
65MP0005319_abnormal_enzyme/_coenzyme0.81123663
66MP0009672_abnormal_birth_weight0.78920367
67MP0005386_behavior/neurological_phenoty0.76193040
68MP0004924_abnormal_behavior0.76193040
69MP0002233_abnormal_nose_morphology0.74013571
70MP0003303_peritoneal_inflammation0.67204787
71MP0005164_abnormal_response_to0.66251742
72MP0000015_abnormal_ear_pigmentation0.65979870
73MP0001919_abnormal_reproductive_system0.63029821
74MP0003787_abnormal_imprinting0.63008731
75MP0002111_abnormal_tail_morphology0.62595393
76MP0005408_hypopigmentation0.61793757
77MP0000427_abnormal_hair_cycle0.61205582
78MP0001963_abnormal_hearing_physiology0.60425534
79MP0003635_abnormal_synaptic_transmissio0.58637023
80MP0001191_abnormal_skin_condition0.58245287
81MP0000367_abnormal_coat/_hair0.57241587
82MP0001501_abnormal_sleep_pattern0.53440355
83MP0009763_increased_sensitivity_to0.53006942
84MP0004381_abnormal_hair_follicle0.52790028
85MP0002751_abnormal_autonomic_nervous0.51565756
86MP0003948_abnormal_gas_homeostasis0.51061321
87MP0003283_abnormal_digestive_organ0.50893813
88MP0005395_other_phenotype0.49953015
89MP0002272_abnormal_nervous_system0.49698226
90MP0006138_congestive_heart_failure0.48815001
91MP0003077_abnormal_cell_cycle0.48012010
92MP0002932_abnormal_joint_morphology0.47312586
93MP0002736_abnormal_nociception_after0.47085802
94MP0002557_abnormal_social/conspecific_i0.46317313
95MP0001968_abnormal_touch/_nociception0.46200007
96MP0002063_abnormal_learning/memory/cond0.45011495
97MP0003638_abnormal_response/metabolism_0.43943830
98MP0010329_abnormal_lipoprotein_level0.43254944
99MP0000703_abnormal_thymus_morphology0.42273473
100MP0005448_abnormal_energy_balance0.42018542

Predicted human phenotypes

RankGene SetZ-score
1Aplasia cutis congenita (HP:0001057)8.94078551
2Increased serum pyruvate (HP:0003542)7.86008661
3Abnormality of glycolysis (HP:0004366)6.95487020
4Gastrointestinal atresia (HP:0002589)6.75238459
5Ureteral stenosis (HP:0000071)6.03898579
6Increased connective tissue (HP:0009025)5.95945345
7Ureteral obstruction (HP:0006000)5.65161259
8Milia (HP:0001056)5.57021589
9Atrophic scars (HP:0001075)5.32005093
10Ragged-red muscle fibers (HP:0003200)5.30641731
11Fragile skin (HP:0001030)5.16635409
12Hypokinesia (HP:0002375)4.61385435
13Pterygium (HP:0001059)4.48846708
14Blue irides (HP:0000635)4.46414169
15Hyperventilation (HP:0002883)4.37776279
16Ectropion (HP:0000656)4.18504479
17Freckling (HP:0001480)4.09728748
18Melanoma (HP:0002861)3.98188506
19Atrioventricular canal defect (HP:0006695)3.85215873
20Tetraplegia (HP:0002445)3.63874556
21Small intestinal stenosis (HP:0012848)3.29795009
22Duodenal stenosis (HP:0100867)3.29795009
23Curly hair (HP:0002212)3.29744156
24Chronic hepatic failure (HP:0100626)3.19949842
25Amblyopia (HP:0000646)3.09683218
26Neoplasm of the pancreas (HP:0002894)2.98305408
27Atonic seizures (HP:0010819)2.94266725
28Retinopathy (HP:0000488)2.93814512
29Clumsiness (HP:0002312)2.86065750
30Hepatocellular necrosis (HP:0001404)2.85397460
31Redundant skin (HP:0001582)2.79331502
32Abnormality of the prostate (HP:0008775)2.78788070
33Hypoplasia of the fovea (HP:0007750)2.69975062
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.69975062
35Hypoplasia of dental enamel (HP:0006297)2.65548994
36Status epilepticus (HP:0002133)2.62269860
37Abnormality of the duodenum (HP:0002246)2.55449039
38Aplasia/Hypoplasia of the macula (HP:0008059)2.50434872
39Heterochromia iridis (HP:0001100)2.49522637
40Spinal cord lesions (HP:0100561)2.48984020
41Syringomyelia (HP:0003396)2.48984020
42High anterior hairline (HP:0009890)2.46860824
43Diminished movement (HP:0002374)2.43633411
44Abnormality of midbrain morphology (HP:0002418)2.43507388
45Molar tooth sign on MRI (HP:0002419)2.43507388
46Abnormality of the fovea (HP:0000493)2.38879122
47Increased CSF lactate (HP:0002490)2.36781865
48Aplasia/Hypoplasia affecting the retina (HP:0008061)2.30579709
49Hepatic necrosis (HP:0002605)2.23116090
50Nephronophthisis (HP:0000090)2.16696920
51Intrahepatic cholestasis (HP:0001406)2.11377005
52Large earlobe (HP:0009748)2.09182408
53CNS demyelination (HP:0007305)2.07583510
54Esophageal atresia (HP:0002032)10.2264842
55Abnormality of the aortic arch (HP:0012303)10.1955717
56Prolonged bleeding time (HP:0003010)1.94358029
57Inability to walk (HP:0002540)1.92716524
58Fasciculations (HP:0002380)1.90647752
59Asplenia (HP:0001746)1.88150455
60Exotropia (HP:0000577)1.83048457
61Cystic hygroma (HP:0000476)1.82147901
62Rimmed vacuoles (HP:0003805)1.81587170
63Colon cancer (HP:0003003)1.80453868
64Aplasia/Hypoplasia of the spleen (HP:0010451)1.78850572
65Abnormality of male internal genitalia (HP:0000022)1.77552433
66Papillary thyroid carcinoma (HP:0002895)1.77517327
67Dialeptic seizures (HP:0011146)1.72361811
68Radial bowing (HP:0002986)1.66704566
69Short middle phalanx of finger (HP:0005819)1.66205554
70Stomach cancer (HP:0012126)1.65984866
71Focal seizures (HP:0007359)1.65304356
72Thickened calvaria (HP:0002684)1.63641942
73Abnormality of the renal medulla (HP:0100957)1.61678304
74Abnormality of the phalanges of the 2nd finger (HP:0009541)1.60446483
75Coarse hair (HP:0002208)1.58973358
76Stenosis of the external auditory canal (HP:0000402)1.58899048
77Anonychia (HP:0001798)1.58675122
78Abnormality of the costochondral junction (HP:0000919)1.58150292
79White forelock (HP:0002211)1.57607706
80Fair hair (HP:0002286)1.57469275
81Increased serum lactate (HP:0002151)1.55083565
82Congenital sensorineural hearing impairment (HP:0008527)1.54956322
83Broad metatarsal (HP:0001783)1.51626297
84Chorioretinal coloboma (HP:0000567)1.51141297
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.50983876
86Delayed closure of the anterior fontanelle (HP:0001476)1.50955692
87Steatorrhea (HP:0002570)1.47985858
88Hip dysplasia (HP:0001385)1.47502824
89Patchy hypopigmentation of hair (HP:0011365)1.46588353
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.46029636
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.44085448
92True hermaphroditism (HP:0010459)1.43038656
93Patellar aplasia (HP:0006443)1.42831089
94Recurrent corneal erosions (HP:0000495)1.41841871
95Wide intermamillary distance (HP:0006610)1.41566905
96Absent speech (HP:0001344)1.41249971
97Nail dystrophy (HP:0008404)1.40632463
98Polyneuropathy (HP:0001271)1.39996997
99Pili torti (HP:0003777)1.39065884
100Aplasia of the phalanges of the hand (HP:0009802)1.38498333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K66.57126112
2TLK15.57560711
3MAP3K53.95475861
4MAP4K23.73393616
5SIK22.79652028
6TAOK212.9316791
7RIPK11.81105480
8NME11.70314029
9MAP3K81.66385157
10MAPKAPK31.26336368
11PIK3CA1.08076971
12TAOK31.06395543
13FRK0.93064513
14RIPK40.90865135
15CASK0.79938455
16EEF2K0.78819536
17MELK0.62919572
18TRPM70.56432534
19OXSR10.55811098
20EPHB10.55792922
21MARK30.52426684
22HIPK20.49753993
23PDK20.49522987
24TXK0.48542928
25MST40.47863885
26MAPK70.46892289
27MAPK130.45485721
28STK390.44098225
29MAPKAPK50.42460333
30WNK40.41425695
31TTK0.37771530
32FGFR20.34189137
33RPS6KB20.29942447
34TYK20.28108227
35SIK30.26020266
36GRK60.23390218
37IRAK40.19911753
38STK40.19324504
39RET0.18710452
40NLK0.18677148
41EPHA30.18121301
42PRKCQ0.17877447
43ATR0.17031415
44CCNB10.16251282
45MET0.14527588
46MAPK110.12176026
47CHEK20.12071102
48PDK10.12034420
49TAF10.11774295
50PDPK10.11604086
51WNK30.11413213
52BCR0.11048689
53VRK10.10641796
54PRKD10.10205040
55PLK20.09936748
56FGR0.09634191
57MAP3K70.09510760
58NUAK10.09411259
59PRKCZ0.09282435
60TNIK0.08129615
61PTK2B0.07415388
62PRKAA20.07195091
63PLK40.06820643
64ADRBK20.06091049
65MAPK40.05809490
66MST1R0.05441065
67MAP3K140.05235706
68PRKCG0.05096684
69AURKA0.05063125
70JAK10.04470940
71CDK80.03987479
72ADRBK10.03770060
73CAMK1D0.03750967
74PRKAA10.03235892
75PAK30.03002306
76BTK0.02660862
77CSNK1G30.02383086
78GRK50.02013595
79HCK0.01880091
80IRAK20.01647582
81IGF1R0.01520772
82TEC0.01223628
83PRKACB0.01095984
84MINK10.01020470
85PLK30.00897351
86MAP2K20.00648640
87CSNK1A10.00192612
88PRKCA-0.0327486
89BLK-0.0289512
90MAPK8-0.0282520
91CSNK1A1L-0.0257602
92ATM-0.0213776
93CSNK2A1-0.0195576
94MARK2-0.0193439
95ABL1-0.0103160
96PRKACG-0.0074425
97DYRK1A-0.0061533
98PRKG1-0.0030135
99LYN-0.0029417
100MAPK12-0.0001733

Predicted pathways (KEGG)

RankGene SetZ-score
1Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050144.87700551
2Fc epsilon RI signaling pathway_Homo sapiens_hsa046644.00811888
3Toxoplasmosis_Homo sapiens_hsa051453.44371821
4Cocaine addiction_Homo sapiens_hsa050303.01671364
5GnRH signaling pathway_Homo sapiens_hsa049122.99541735
6Osteoclast differentiation_Homo sapiens_hsa043802.72702618
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.68644784
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.50780668
9Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.40357278
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38492964
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.28222321
12TNF signaling pathway_Homo sapiens_hsa046682.14685329
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.95775010
14Regulation of autophagy_Homo sapiens_hsa041401.95172637
15Influenza A_Homo sapiens_hsa051641.95156010
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.93709215
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81969603
18Selenocompound metabolism_Homo sapiens_hsa004501.70222820
19Phototransduction_Homo sapiens_hsa047441.69572608
20Hematopoietic cell lineage_Homo sapiens_hsa046401.63054524
21Homologous recombination_Homo sapiens_hsa034401.60886302
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58433717
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44955557
24Dilated cardiomyopathy_Homo sapiens_hsa054141.42259512
25Dorso-ventral axis formation_Homo sapiens_hsa043201.39529141
26Circadian rhythm_Homo sapiens_hsa047101.39157215
27Asthma_Homo sapiens_hsa053101.29332776
28Rap1 signaling pathway_Homo sapiens_hsa040151.11936899
29Fanconi anemia pathway_Homo sapiens_hsa034601.05633644
30Butanoate metabolism_Homo sapiens_hsa006501.05377248
31Allograft rejection_Homo sapiens_hsa053301.02038506
32MAPK signaling pathway_Homo sapiens_hsa040101.01984014
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.01677700
34TGF-beta signaling pathway_Homo sapiens_hsa043501.00209833
35Small cell lung cancer_Homo sapiens_hsa052220.99640427
36Autoimmune thyroid disease_Homo sapiens_hsa053200.98895721
37Parkinsons disease_Homo sapiens_hsa050120.92917617
38Steroid hormone biosynthesis_Homo sapiens_hsa001400.90914108
39Salivary secretion_Homo sapiens_hsa049700.90177244
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88977848
41Acute myeloid leukemia_Homo sapiens_hsa052210.88611487
42Oxidative phosphorylation_Homo sapiens_hsa001900.86711726
43Alzheimers disease_Homo sapiens_hsa050100.76238883
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75885953
45Olfactory transduction_Homo sapiens_hsa047400.74556263
46Pertussis_Homo sapiens_hsa051330.74208251
47Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73700719
48Graft-versus-host disease_Homo sapiens_hsa053320.73348472
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72851551
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71352500
51Mismatch repair_Homo sapiens_hsa034300.70458042
52ECM-receptor interaction_Homo sapiens_hsa045120.68626840
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66854317
54Systemic lupus erythematosus_Homo sapiens_hsa053220.65033252
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64986405
56Histidine metabolism_Homo sapiens_hsa003400.63734828
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63496920
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63335552
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62960854
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62846786
61Basal transcription factors_Homo sapiens_hsa030220.60552268
62Epstein-Barr virus infection_Homo sapiens_hsa051690.59886499
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57909524
64Glutathione metabolism_Homo sapiens_hsa004800.55876551
65T cell receptor signaling pathway_Homo sapiens_hsa046600.55807578
66Glucagon signaling pathway_Homo sapiens_hsa049220.55162736
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54101891
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52034540
69Chemical carcinogenesis_Homo sapiens_hsa052040.51957499
70Pyrimidine metabolism_Homo sapiens_hsa002400.51843712
71Leishmaniasis_Homo sapiens_hsa051400.51640928
72Amphetamine addiction_Homo sapiens_hsa050310.50484153
73Fatty acid elongation_Homo sapiens_hsa000620.49599759
74MicroRNAs in cancer_Homo sapiens_hsa052060.49014417
75Hepatitis B_Homo sapiens_hsa051610.47956138
76Staphylococcus aureus infection_Homo sapiens_hsa051500.47189929
77Prostate cancer_Homo sapiens_hsa052150.44214740
78Nicotine addiction_Homo sapiens_hsa050330.44185487
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.44004082
80ErbB signaling pathway_Homo sapiens_hsa040120.42017117
81Glioma_Homo sapiens_hsa052140.41383114
82Circadian entrainment_Homo sapiens_hsa047130.41262490
83Arachidonic acid metabolism_Homo sapiens_hsa005900.39451995
84Oxytocin signaling pathway_Homo sapiens_hsa049210.37944458
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37898660
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37338513
87Pathways in cancer_Homo sapiens_hsa052000.37263668
88Non-small cell lung cancer_Homo sapiens_hsa052230.34074502
89Primary immunodeficiency_Homo sapiens_hsa053400.33579762
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.33250927
91Retinol metabolism_Homo sapiens_hsa008300.32791285
92FoxO signaling pathway_Homo sapiens_hsa040680.32315196
93Herpes simplex infection_Homo sapiens_hsa051680.32257410
94Phagosome_Homo sapiens_hsa041450.31883247
95Tuberculosis_Homo sapiens_hsa051520.30513456
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.28351684
97Type I diabetes mellitus_Homo sapiens_hsa049400.27800921
98HIF-1 signaling pathway_Homo sapiens_hsa040660.27086592
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.24267992
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.23855856

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