SNRPGP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)8.41805211
2negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 8.08821075
3signal complex assembly (GO:0007172)7.63709845
4maturation of 5.8S rRNA (GO:0000460)7.53510657
5negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)6.59052213
6positive regulation of translational initiation (GO:0045948)6.54323838
7regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 6.54109351
8positive regulation of signal transduction by p53 class mediator (GO:1901798)6.43475813
9secretory granule organization (GO:0033363)6.42502169
10regulation of mitochondrial translation (GO:0070129)6.11897783
11cytochrome complex assembly (GO:0017004)5.97686511
12megakaryocyte development (GO:0035855)5.94075707
13regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)5.20462872
14protein complex biogenesis (GO:0070271)4.79550962
15DNA replication-dependent nucleosome assembly (GO:0006335)4.63556734
16DNA replication-dependent nucleosome organization (GO:0034723)4.63556734
17pseudouridine synthesis (GO:0001522)4.53103389
18negative regulation of translational initiation (GO:0045947)4.46998743
19negative regulation of signal transduction by p53 class mediator (GO:1901797)4.33055630
20mitochondrial respiratory chain complex assembly (GO:0033108)4.31140977
21DNA double-strand break processing (GO:0000729)4.25597427
22neural tube formation (GO:0001841)4.18921510
23platelet formation (GO:0030220)4.12038546
24limb bud formation (GO:0060174)4.11342370
25C4-dicarboxylate transport (GO:0015740)4.04276638
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.96036462
27regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)3.74674982
28peptidyl-histidine modification (GO:0018202)3.72476340
29regulation of translation in response to stress (GO:0043555)3.71981960
30respiratory chain complex IV assembly (GO:0008535)3.67082677
31neuronal action potential propagation (GO:0019227)3.57444780
32presynaptic membrane assembly (GO:0097105)3.56756579
33ribosomal small subunit biogenesis (GO:0042274)3.48566792
34negative regulation of mast cell activation (GO:0033004)3.46172969
35presynaptic membrane organization (GO:0097090)3.39646524
36negative regulation of membrane potential (GO:0045837)3.32146446
37replication fork processing (GO:0031297)3.28677474
38rRNA modification (GO:0000154)3.26216296
39platelet dense granule organization (GO:0060155)3.21324001
40piRNA metabolic process (GO:0034587)3.20488518
41negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.16247400
42fusion of sperm to egg plasma membrane (GO:0007342)3.15336775
43regulation of double-strand break repair via homologous recombination (GO:0010569)3.14128325
44ubiquinone biosynthetic process (GO:0006744)3.11802997
45chromatin remodeling at centromere (GO:0031055)3.08768745
46behavioral response to nicotine (GO:0035095)3.07807001
47ubiquinone metabolic process (GO:0006743)3.05948248
48olfactory bulb development (GO:0021772)3.02013471
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01678311
50positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93894111
51mechanosensory behavior (GO:0007638)2.92671744
52DNA replication-independent nucleosome organization (GO:0034724)2.88859328
53DNA replication-independent nucleosome assembly (GO:0006336)2.88859328
54negative regulation of transcription regulatory region DNA binding (GO:2000678)2.87644487
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87285807
56mitochondrial respiratory chain complex I assembly (GO:0032981)2.87285807
57NADH dehydrogenase complex assembly (GO:0010257)2.87285807
58resolution of meiotic recombination intermediates (GO:0000712)2.87200012
59kinetochore organization (GO:0051383)2.86929686
60histone exchange (GO:0043486)2.83390604
61CENP-A containing nucleosome assembly (GO:0034080)2.82260412
62intraciliary transport (GO:0042073)2.79565222
63positive regulation of macrophage differentiation (GO:0045651)2.79548937
64kinetochore assembly (GO:0051382)2.79159792
65regulation of signal transduction by p53 class mediator (GO:1901796)2.78689410
66regulation of activation of Janus kinase activity (GO:0010533)2.75918806
67protein-cofactor linkage (GO:0018065)2.73500825
68signal peptide processing (GO:0006465)2.71704699
69histone H2A acetylation (GO:0043968)2.71643199
70DNA packaging (GO:0006323)2.70241874
71microtubule depolymerization (GO:0007019)2.67392984
72T cell apoptotic process (GO:0070231)2.65890676
73regulation of timing of cell differentiation (GO:0048505)2.65840173
74retinal ganglion cell axon guidance (GO:0031290)2.63908550
75myeloid cell development (GO:0061515)2.63756893
76cell proliferation in forebrain (GO:0021846)2.61753455
77double-strand break repair via homologous recombination (GO:0000724)2.61731177
78recombinational repair (GO:0000725)2.61495494
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59947415
80DNA damage response, detection of DNA damage (GO:0042769)2.59142614
81somite development (GO:0061053)2.58145377
82postsynaptic membrane organization (GO:0001941)2.54289166
83oligodendrocyte development (GO:0014003)2.53089709
84sympathetic nervous system development (GO:0048485)2.51610233
85cornea development in camera-type eye (GO:0061303)2.51315777
86otic vesicle formation (GO:0030916)2.50416631
87quinone biosynthetic process (GO:1901663)2.50366508
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49823943
89pyrimidine nucleobase catabolic process (GO:0006208)2.44807958
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43910872
91protein kinase B signaling (GO:0043491)2.40544732
92epithelial cilium movement (GO:0003351)2.39466265
93gamma-aminobutyric acid transport (GO:0015812)2.39223650
94positive regulation of response to DNA damage stimulus (GO:2001022)2.39162887
95transmission of nerve impulse (GO:0019226)2.39133748
96plasma membrane fusion (GO:0045026)2.38580966
97protein K6-linked ubiquitination (GO:0085020)2.38069116
98translesion synthesis (GO:0019985)2.35480852
99regulation of development, heterochronic (GO:0040034)2.34378066
100RNA localization (GO:0006403)11.0796412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.95490718
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.73555450
3EZH2_22144423_ChIP-Seq_EOC_Human2.75307825
4GBX2_23144817_ChIP-Seq_PC3_Human2.73659368
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61343641
6ZNF274_21170338_ChIP-Seq_K562_Hela2.59286585
7IGF1R_20145208_ChIP-Seq_DFB_Human2.58334954
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58113261
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55462049
10VDR_22108803_ChIP-Seq_LS180_Human2.46161931
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.24075020
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15806331
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13448635
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.12807248
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04288663
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.01922032
17E2F7_22180533_ChIP-Seq_HELA_Human1.99278238
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97443080
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94362002
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87238261
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86444679
22RNF2_27304074_Chip-Seq_NSC_Mouse1.85846637
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85487200
24EWS_26573619_Chip-Seq_HEK293_Human1.84384413
25FUS_26573619_Chip-Seq_HEK293_Human1.83835004
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.81281935
27P300_19829295_ChIP-Seq_ESCs_Human1.77206063
28AR_21572438_ChIP-Seq_LNCaP_Human1.74935087
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70317557
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69762942
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67868333
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65000467
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63488463
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.61776448
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57218367
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.57100631
37TP53_16413492_ChIP-PET_HCT116_Human1.52910346
38ELK1_19687146_ChIP-ChIP_HELA_Human1.51790704
39TAF15_26573619_Chip-Seq_HEK293_Human1.51271085
40MYC_18940864_ChIP-ChIP_HL60_Human1.51227241
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50783703
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49353883
43TBX3_20139965_ChIP-Seq_ESCs_Mouse1.49136968
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48746880
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48736941
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48736941
47TBX3_20139965_ChIP-Seq_MESCs_Mouse1.48622789
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47456383
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47245536
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.46380072
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43614275
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39695909
53ER_23166858_ChIP-Seq_MCF-7_Human1.38400450
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34570121
55CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.32316340
56SMAD4_21799915_ChIP-Seq_A2780_Human1.31787572
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31510826
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30845367
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.30619301
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30492231
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30365433
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29711125
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27619165
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27114903
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.26858977
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23853093
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23045241
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22492459
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.21217990
70EGR1_19032775_ChIP-ChIP_M12_Human1.20673597
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20134977
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19893558
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19403777
74RUNX2_22187159_ChIP-Seq_PCA_Human1.18342594
75STAT3_23295773_ChIP-Seq_U87_Human1.18065179
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17718869
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17234965
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16220210
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14448956
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12398095
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.11504969
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09688858
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09088918
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.07430780
85TCF4_23295773_ChIP-Seq_U87_Human1.07022046
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06949834
87AR_25329375_ChIP-Seq_VCAP_Human1.06406237
88TCF4_22108803_ChIP-Seq_LS180_Human1.05979558
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05737018
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05684378
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.03975299
92P53_22387025_ChIP-Seq_ESCs_Mouse1.03670470
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03439091
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02524090
95KDM2B_26808549_Chip-Seq_REH_Human1.01713464
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.01682730
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01014610
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00208756
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.98645336
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98300822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.77066451
2MP0006292_abnormal_olfactory_placode3.81482683
3MP0004145_abnormal_muscle_electrophysio2.73929457
4MP0003880_abnormal_central_pattern2.31081488
5MP0002163_abnormal_gland_morphology2.21464460
6MP0008789_abnormal_olfactory_epithelium2.17413842
7MP0006072_abnormal_retinal_apoptosis2.14951035
8MP0002736_abnormal_nociception_after2.13841050
9MP0004885_abnormal_endolymph2.12801802
10MP0003787_abnormal_imprinting2.12307953
11MP0002938_white_spotting2.02291614
12MP0010094_abnormal_chromosome_stability1.95123143
13MP0002102_abnormal_ear_morphology1.80776344
14MP0000049_abnormal_middle_ear1.76217519
15MP0005187_abnormal_penis_morphology1.73881729
16MP0000778_abnormal_nervous_system1.68485097
17MP0008058_abnormal_DNA_repair1.64524770
18MP0005394_taste/olfaction_phenotype1.64432896
19MP0005499_abnormal_olfactory_system1.64432896
20MP0006035_abnormal_mitochondrial_morpho1.58748731
21MP0005248_abnormal_Harderian_gland1.57874476
22MP0005646_abnormal_pituitary_gland1.57508858
23MP0005551_abnormal_eye_electrophysiolog1.57040785
24MP0005253_abnormal_eye_physiology1.55830190
25MP0001968_abnormal_touch/_nociception1.55550156
26MP0003121_genomic_imprinting1.52177678
27MP0008877_abnormal_DNA_methylation1.51938419
28MP0002751_abnormal_autonomic_nervous1.51420569
29MP0002277_abnormal_respiratory_mucosa1.50035623
30MP0003937_abnormal_limbs/digits/tail_de1.49884871
31MP0009250_abnormal_appendicular_skeleto1.49185524
32MP0000534_abnormal_ureter_morphology1.48896548
33MP0001529_abnormal_vocalization1.48264694
34MP0001486_abnormal_startle_reflex1.43831717
35MP0003755_abnormal_palate_morphology1.40340576
36MP0005174_abnormal_tail_pigmentation1.39962199
37MP0009046_muscle_twitch1.37278175
38MP0009745_abnormal_behavioral_response1.34912103
39MP0010307_abnormal_tumor_latency1.34276311
40MP0002233_abnormal_nose_morphology1.33938496
41MP0005423_abnormal_somatic_nervous1.30753660
42MP0000372_irregular_coat_pigmentation1.29054704
43MP0004147_increased_porphyrin_level1.26305760
44MP0002638_abnormal_pupillary_reflex1.25666831
45MP0005410_abnormal_fertilization1.23539272
46MP0006276_abnormal_autonomic_nervous1.23310922
47MP0003137_abnormal_impulse_conducting1.22148761
48MP0004957_abnormal_blastocyst_morpholog1.20730722
49MP0003011_delayed_dark_adaptation1.20406977
50MP0003315_abnormal_perineum_morphology1.19106936
51MP0000631_abnormal_neuroendocrine_gland1.19027642
52MP0002184_abnormal_innervation1.19002184
53MP0003195_calcinosis1.16445122
54MP0002095_abnormal_skin_pigmentation1.15258987
55MP0000516_abnormal_urinary_system1.14810371
56MP0005367_renal/urinary_system_phenotyp1.14810371
57MP0009697_abnormal_copulation1.13422388
58MP0002272_abnormal_nervous_system1.13028808
59MP0004142_abnormal_muscle_tone1.10519251
60MP0003119_abnormal_digestive_system1.10253153
61MP0005379_endocrine/exocrine_gland_phen1.10183981
62MP0000647_abnormal_sebaceous_gland1.09028567
63MP0002249_abnormal_larynx_morphology1.08648238
64MP0005503_abnormal_tendon_morphology1.08328891
65MP0003122_maternal_imprinting1.06878669
66MP0000462_abnormal_digestive_system1.05539566
67MP0008932_abnormal_embryonic_tissue1.04701959
68MP0002557_abnormal_social/conspecific_i1.04107848
69MP0002752_abnormal_somatic_nervous1.03987162
70MP0003635_abnormal_synaptic_transmissio1.01279795
71MP0002735_abnormal_chemical_nociception1.01011893
72MP0002822_catalepsy0.99744972
73MP0004215_abnormal_myocardial_fiber0.99110105
74MP0003718_maternal_effect0.97965528
75MP0002210_abnormal_sex_determination0.96360882
76MP0001485_abnormal_pinna_reflex0.96298971
77MP0001286_abnormal_eye_development0.95399842
78MP0002160_abnormal_reproductive_system0.94376534
79MP0003385_abnormal_body_wall0.94128023
80MP0000026_abnormal_inner_ear0.94056156
81MP0005084_abnormal_gallbladder_morpholo0.93936961
82MP0005391_vision/eye_phenotype0.93611477
83MP0003938_abnormal_ear_development0.92546957
84MP0005389_reproductive_system_phenotype0.92046185
85MP0005623_abnormal_meninges_morphology0.90572568
86MP0003567_abnormal_fetal_cardiomyocyte0.89349131
87MP0005195_abnormal_posterior_eye0.88497689
88MP0003111_abnormal_nucleus_morphology0.87811975
89MP0002234_abnormal_pharynx_morphology0.87262062
90MP0004133_heterotaxia0.86767647
91MP0003786_premature_aging0.86579413
92MP0003693_abnormal_embryo_hatching0.85665299
93MP0002734_abnormal_mechanical_nocicepti0.85625313
94MP0003861_abnormal_nervous_system0.83945892
95MP0003186_abnormal_redox_activity0.83787706
96MP0000579_abnormal_nail_morphology0.83504961
97MP0002064_seizures0.82359976
98MP0004043_abnormal_pH_regulation0.81952905
99MP0000428_abnormal_craniofacial_morphol0.81453024
100MP0001119_abnormal_female_reproductive0.80997682

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.95985448
2Cerebral hypomyelination (HP:0006808)3.90822860
3Focal motor seizures (HP:0011153)3.38695901
4True hermaphroditism (HP:0010459)3.11022994
53-Methylglutaconic aciduria (HP:0003535)2.99786935
6Abnormality of midbrain morphology (HP:0002418)2.89888054
7Molar tooth sign on MRI (HP:0002419)2.89888054
8Chronic hepatic failure (HP:0100626)2.88608822
9Secondary amenorrhea (HP:0000869)2.87501218
10Delusions (HP:0000746)2.87486030
11Premature ovarian failure (HP:0008209)2.82765797
12Pancreatic cysts (HP:0001737)2.73709221
13Nephronophthisis (HP:0000090)2.73390642
14Concave nail (HP:0001598)2.70090177
15Acute necrotizing encephalopathy (HP:0006965)2.69474612
16Pancreatic fibrosis (HP:0100732)2.67843169
17Abnormality of chromosome stability (HP:0003220)2.66426375
18Intestinal atresia (HP:0011100)2.62451299
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.61815612
20Colon cancer (HP:0003003)2.57768120
21Volvulus (HP:0002580)2.56970646
22Astrocytoma (HP:0009592)2.55771880
23Abnormality of the astrocytes (HP:0100707)2.55771880
24Pendular nystagmus (HP:0012043)2.53800163
25Abnormality of the labia minora (HP:0012880)2.49297080
26Testicular atrophy (HP:0000029)2.49090509
27Dyschromatopsia (HP:0007641)2.47559820
28Small epiphyses (HP:0010585)2.46628525
29Hemiparesis (HP:0001269)2.41004573
30Hepatoblastoma (HP:0002884)2.40346458
31Meckel diverticulum (HP:0002245)2.39924354
32Abnormality of the renal medulla (HP:0100957)2.34071716
33Abnormality of the ileum (HP:0001549)2.33686908
34Abnormality of the renal cortex (HP:0011035)2.32291495
35Hemiplegia (HP:0002301)2.31709896
36Bifid tongue (HP:0010297)2.27953734
37Dyskinesia (HP:0100660)2.25999122
38Abolished electroretinogram (ERG) (HP:0000550)2.25304140
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.24724537
40Abnormal biliary tract physiology (HP:0012439)2.24000054
41Bile duct proliferation (HP:0001408)2.24000054
42Progressive macrocephaly (HP:0004481)2.23822818
43Triphalangeal thumb (HP:0001199)2.23793318
44Median cleft lip (HP:0000161)2.23517264
45Keratoconus (HP:0000563)2.20797241
46Increased corneal curvature (HP:0100692)2.20797241
47Glioma (HP:0009733)2.16316839
48Increased CSF lactate (HP:0002490)2.15130765
49Mitochondrial inheritance (HP:0001427)2.14865552
50Focal seizures (HP:0007359)2.14582720
51Abnormal mitochondria in muscle tissue (HP:0008316)2.14166135
52Acute encephalopathy (HP:0006846)2.13945929
53Congenital stationary night blindness (HP:0007642)2.13445522
54Patellar aplasia (HP:0006443)2.10897308
55Medial flaring of the eyebrow (HP:0010747)2.07470368
56Aplasia/Hypoplasia of the sternum (HP:0006714)2.05631158
57Morphological abnormality of the inner ear (HP:0011390)2.05609959
58Aplasia/Hypoplasia of the patella (HP:0006498)2.03923435
59Ectopic kidney (HP:0000086)2.02807918
60Abnormal lung lobation (HP:0002101)2.02661344
61Hyperglycinemia (HP:0002154)2.01996824
62Short tibia (HP:0005736)2.01265712
63CNS hypomyelination (HP:0003429)1.98336928
64Irregular epiphyses (HP:0010582)1.97694923
65Oligodactyly (hands) (HP:0001180)1.97652146
66Gastrointestinal atresia (HP:0002589)1.97106026
67Megalencephaly (HP:0001355)1.96974718
68Carpal bone hypoplasia (HP:0001498)1.96372270
69Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95914049
70Abnormality of cochlea (HP:0000375)1.92972552
71Abnormal number of incisors (HP:0011064)1.92354125
72Preaxial hand polydactyly (HP:0001177)1.92237875
73Postnatal microcephaly (HP:0005484)1.92226285
74Renal hypoplasia (HP:0000089)1.91500982
75Renal cortical cysts (HP:0000803)1.90086239
76Septo-optic dysplasia (HP:0100842)1.87836298
77Adactyly (HP:0009776)1.85574808
78CNS demyelination (HP:0007305)1.84680209
79Tubular atrophy (HP:0000092)1.84357298
80Clubbing of toes (HP:0100760)1.82613306
81Narrow forehead (HP:0000341)1.81963414
82Abnormality of the preputium (HP:0100587)1.81663673
83Absent phalangeal crease (HP:0006109)1.81185596
84Postaxial hand polydactyly (HP:0001162)1.81174832
85Congenital primary aphakia (HP:0007707)1.80079622
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.80066698
87Sclerocornea (HP:0000647)1.78711326
88Sloping forehead (HP:0000340)1.78520208
89Postaxial foot polydactyly (HP:0001830)1.78373777
90Genital tract atresia (HP:0001827)1.77179001
91Agitation (HP:0000713)1.76618820
92Abnormality of the antihelix (HP:0009738)1.74901671
93Optic nerve hypoplasia (HP:0000609)1.74566780
94Abnormality of the duodenum (HP:0002246)1.74522468
95Unsteady gait (HP:0002317)1.73055897
96Gait imbalance (HP:0002141)1.72975225
97IgM deficiency (HP:0002850)1.72717035
98Anencephaly (HP:0002323)1.70519178
99Male pseudohermaphroditism (HP:0000037)1.70210851
100Abnormality of the carotid arteries (HP:0005344)1.69948560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK19.64897480
2PRKCI2.90388996
3WNK32.52552984
4STK38L2.38575692
5BMPR22.37635766
6MARK12.26170133
7NEK12.08143591
8EIF2AK31.97998300
9FRK1.95034807
10MAP4K21.91802004
11MAPK131.87070331
12NUAK11.82277473
13CASK1.73250969
14BMPR1B1.67846569
15WEE11.64046695
16CDC71.62832798
17TNIK1.57289827
18PRKCG1.56256313
19CDK81.54122005
20MAP4K11.51608196
21BUB11.47364696
22MKNK21.42277692
23YES11.39952876
24PLK41.39325267
25CCNB11.36627062
26PKN11.36182840
27MAP3K41.29768377
28PRKCE1.28948210
29STK391.23689807
30BRSK11.13938765
31ADRBK21.09806233
32DMPK1.07489662
33BRSK21.05659097
34GRK10.99193866
35PLK30.96203900
36LIMK10.95325077
37MKNK10.94490562
38TRIM280.93278783
39WNK40.93054247
40PDPK10.92283624
41PLK20.89327968
42ZAK0.85929364
43SRPK10.85266769
44DYRK20.84651663
45PASK0.84314883
46NTRK20.80838736
47EIF2AK10.76677730
48PRKCZ0.76339703
49DAPK30.74109595
50INSRR0.74014886
51EPHA40.73446546
52PLK10.71417244
53CSNK1G20.71230025
54MAPKAPK30.71149674
55MAP2K70.67693195
56CSNK1G10.64298165
57PINK10.63873164
58CDK30.58399595
59CSNK1G30.58265021
60PRKD30.58132600
61STK240.56372049
62EPHB20.55959930
63TTK0.55588804
64ROCK10.54534013
65ATR0.51828954
66PDK20.46295731
67ACVR1B0.45983810
68PRKCB0.45944038
69PRKCD0.44928142
70PBK0.41085902
71CSNK2A10.40258064
72TGFBR10.39849662
73STK40.39350989
74VRK10.38304005
75ATM0.38228045
76EIF2AK20.38203372
77CLK10.38172671
78MINK10.37792053
79STK30.36900266
80PTK2B0.36717164
81PNCK0.36506100
82FGR0.35005245
83CHEK20.34757137
84CAMKK20.34566534
85TIE10.33415835
86CSNK1A10.32499829
87CSNK2A20.31906315
88CSNK1A1L0.31538490
89AURKB0.29797038
90CSNK1D0.29521023
91CHEK10.29151656
92BCR0.28991220
93CDC42BPA0.28850730
94RPS6KA50.27938806
95OXSR10.27662386
96CDK180.27231162
97PRKCQ0.26902572
98CDK150.26040829
99PRKACA0.25264212
100PAK30.25181146

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.45370391
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.38728075
3Tyrosine metabolism_Homo sapiens_hsa003503.33042575
4Protein export_Homo sapiens_hsa030603.31787680
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64126524
6Fanconi anemia pathway_Homo sapiens_hsa034602.52368014
7Ribosome_Homo sapiens_hsa030102.45405273
8RNA degradation_Homo sapiens_hsa030182.27523948
9Lysine degradation_Homo sapiens_hsa003102.21758785
10Oxidative phosphorylation_Homo sapiens_hsa001902.18216730
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12262893
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92192082
13Parkinsons disease_Homo sapiens_hsa050121.91850926
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67245085
15Homologous recombination_Homo sapiens_hsa034401.66656227
16Fatty acid metabolism_Homo sapiens_hsa012121.64740116
17DNA replication_Homo sapiens_hsa030301.63535569
18Nicotine addiction_Homo sapiens_hsa050331.59356019
19Olfactory transduction_Homo sapiens_hsa047401.56863323
20Non-homologous end-joining_Homo sapiens_hsa034501.54654928
21RNA polymerase_Homo sapiens_hsa030201.54204632
22Huntingtons disease_Homo sapiens_hsa050161.54149196
23Regulation of autophagy_Homo sapiens_hsa041401.50248457
24RNA transport_Homo sapiens_hsa030131.43296010
25Nitrogen metabolism_Homo sapiens_hsa009101.43137388
26Proteasome_Homo sapiens_hsa030501.41966088
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31802463
28Fatty acid elongation_Homo sapiens_hsa000621.30300735
29Phototransduction_Homo sapiens_hsa047441.30221928
30TGF-beta signaling pathway_Homo sapiens_hsa043501.29838172
31Cardiac muscle contraction_Homo sapiens_hsa042601.27279915
32Butanoate metabolism_Homo sapiens_hsa006501.24305265
33Basal transcription factors_Homo sapiens_hsa030221.19175826
34Fatty acid degradation_Homo sapiens_hsa000711.18937701
35Propanoate metabolism_Homo sapiens_hsa006401.17692980
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16772257
37Pyrimidine metabolism_Homo sapiens_hsa002401.16254635
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15930990
39ErbB signaling pathway_Homo sapiens_hsa040121.08956272
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08908868
41Alzheimers disease_Homo sapiens_hsa050101.08386352
42Cell cycle_Homo sapiens_hsa041101.06477852
43Spliceosome_Homo sapiens_hsa030401.03614194
44Axon guidance_Homo sapiens_hsa043601.02719808
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00687835
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99386238
47Tryptophan metabolism_Homo sapiens_hsa003800.92739707
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87957693
49Retinol metabolism_Homo sapiens_hsa008300.86050773
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85831844
51Peroxisome_Homo sapiens_hsa041460.83228039
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82751590
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82642675
54Glutathione metabolism_Homo sapiens_hsa004800.80943737
55Mismatch repair_Homo sapiens_hsa034300.80122333
56Fat digestion and absorption_Homo sapiens_hsa049750.77103587
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76034963
58beta-Alanine metabolism_Homo sapiens_hsa004100.75392262
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74981063
60Chemical carcinogenesis_Homo sapiens_hsa052040.74881886
61Purine metabolism_Homo sapiens_hsa002300.73756086
62Basal cell carcinoma_Homo sapiens_hsa052170.73351824
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71620783
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71579252
65Linoleic acid metabolism_Homo sapiens_hsa005910.71548951
66Dorso-ventral axis formation_Homo sapiens_hsa043200.71276209
67Glycerolipid metabolism_Homo sapiens_hsa005610.71010776
68Base excision repair_Homo sapiens_hsa034100.68585362
69mTOR signaling pathway_Homo sapiens_hsa041500.68295134
70Graft-versus-host disease_Homo sapiens_hsa053320.65633724
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65350237
72Tight junction_Homo sapiens_hsa045300.64951618
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63028233
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63020834
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.59443820
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57469606
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55919008
78Taste transduction_Homo sapiens_hsa047420.55115882
79Caffeine metabolism_Homo sapiens_hsa002320.51554244
80Nucleotide excision repair_Homo sapiens_hsa034200.51263023
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49772194
82Choline metabolism in cancer_Homo sapiens_hsa052310.48569892
83p53 signaling pathway_Homo sapiens_hsa041150.46568199
84Metabolic pathways_Homo sapiens_hsa011000.45474723
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.42854259
86Morphine addiction_Homo sapiens_hsa050320.42145745
87Hedgehog signaling pathway_Homo sapiens_hsa043400.41514053
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40668654
89Mineral absorption_Homo sapiens_hsa049780.39853943
90Steroid biosynthesis_Homo sapiens_hsa001000.37354846
91Pyruvate metabolism_Homo sapiens_hsa006200.33271070
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31832456
93Salivary secretion_Homo sapiens_hsa049700.31283248
94Wnt signaling pathway_Homo sapiens_hsa043100.30956980
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30889165
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30648174
97Oocyte meiosis_Homo sapiens_hsa041140.28242885
98PPAR signaling pathway_Homo sapiens_hsa033200.28108515
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.26449479
100Protein digestion and absorption_Homo sapiens_hsa049740.26117209

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